Metadata-Version: 2.1
Name: synergy
Version: 0.1.1
Summary: Python package for calculating drug combination synergy
Home-page: https://github.com/djwooten/synergy
Author: David J. Wooten
Author-email: dwooten@psu.edu
License: UNKNOWN
Description: <img src="https://djwooten.github.io/img/synergy_logo.png" width="400" />
        
        # synergy
        
        A python package to calculate, analyze, and visualize drug combination synergy and antagonism. Currently supports multiple models of synergy, including MuSyC, Bliss, Loewe, Combination Index, ZIP, Zimmer, Schindler, and HSA.
        
        ## Installation
        
        Using PIP
        `pip install synergy`
        
        Using conda
        `not yet`
        
        Using git
        `git clone ...`
        
        ## Requirements
        * python >= 3.5
        * numpy >= 1.13.0
        * scipy >= 0.18.0
        * Optional for full plotting functionality
          * matplotlib
          * plotly
        
        ## Current features
        * Calculate two-drug synergy using
          * Parametric
            * MuSyC
            * Zimmer (effective dose model)
            * BRAID
          * Dose-dependent
            * Bliss
            * Loewe
            * Schindler
            * ZIP
            * HSA
            * Combination Index
        * Residual bootstrap re-sampling to obtain confidence intervals for parameters of parametric models
        * Single drug models
          * Parametric
            * Four-parameter Hill equation
            * Two-parameter Hill equation
            * Median-effect equation
          * Non-parametric
            * Piecewise linear
        * Model scoring
          * R-squared
          * Akaike Information Criterion
          * Bayesian Information Criterion
        * Visualization
          * Heatmaps
          * 3D Plotly Surfaces
        * Synthetic data tools
          * Drug dilutions using grid-based sampling
          * "Sham experiment" simulation
        
        ## Planned features
        * Additional models
          * Parametric
            * GPDI
        * Three+ drug combinations (when possible)
          * MuSyC
          * Bliss
          * Loewe / CI
          * HSA
          * Schindler
          * Zimmer (at least incorporating pairwise synergies)
        * Visualization
          * Highlight single-drug curves on 3D surface plots
          * matplotlib 3D surface plotting
          * Contour plots for heatmaps
          * Isobolgrams
        * Additional dose / experiment design tools
          * Alternative dosing strategies
        * Heteroskedastic re-sampling for datasets with >= 3 replicates at each dose
        * Parallelization API for fitting high-throughput screen data
        
        ## License
        GNU General Public License v3 or later (GPLv3+)
        
Keywords: synergy drug combination pharmacology cancer
Platform: UNKNOWN
Classifier: Development Status :: 4 - Beta
Classifier: Intended Audience :: Science/Research
Classifier: Intended Audience :: Education
Classifier: License :: OSI Approved :: GNU General Public License v3 or later (GPLv3+)
Classifier: Natural Language :: English
Classifier: Programming Language :: Python :: 3
Classifier: Programming Language :: Python :: 3.5
Classifier: Programming Language :: Python :: 3.6
Classifier: Programming Language :: Python :: 3.7
Classifier: Programming Language :: Python :: 3.8
Classifier: Operating System :: OS Independent
Classifier: Topic :: Scientific/Engineering :: Bio-Informatics
Classifier: Topic :: Scientific/Engineering :: Medical Science Apps.
Requires-Python: >=3.5
Description-Content-Type: text/markdown
