# emapper version: emapper-1.0.3-35-g63c274b emapper DB: 2.0
# command: ./emapper.py  --cpu 6 -i /data/shared/emapper_jobs/user_data/MM_m33jamty/query_seqs.fa --output query_seqs.fa --output_dir /data/shared/emapper_jobs/user_data/MM_m33jamty -m diamond -d none --tax_scope 561 --go_evidence non-electronic --target_orthologs all --seed_ortholog_evalue 0.001 --seed_ortholog_score 60 --query-cover 20 --subject-cover 0 --override --temp_dir /data/shared/emapper_jobs/user_data/MM_m33jamty
# time: Fri Feb 26 20:12:46 2021
#query_name	seed_eggNOG_ortholog	seed_ortholog_evalue	seed_ortholog_score	best_tax_level	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction
b0002	316407.85674276	0.0	1600.5	Escherichia	thrA	GO:0003674,GO:0003824,GO:0004072,GO:0004412,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000			iECDH1ME8569_1439.ECDH1ME8569_0002,iEcDH1_1363.EcDH1_3594,iSFV_1184.SFV_0001	Escherichia	1MW3H@1224,1RN1G@1236,3XN2A@561,COG0460@1,COG0460@2,COG0527@1,COG0527@2	NA|NA|NA	E	homoserine dehydrogenase I
b0003	316407.85674277	3e-178	630.9	Escherichia	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iECSE_1348.ECSE_0003	Escherichia	1MW8I@1224,1RMYR@1236,3XN01@561,COG0083@1,COG0083@2	NA|NA|NA	F	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
b0004	316407.21321894	1.2e-246	858.6	Escherichia	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000			iLF82_1304.LF82_2261,iNRG857_1313.NRG857_00025	Escherichia	1MUWQ@1224,1RQ0H@1236,3XP31@561,COG0498@1,COG0498@2	NA|NA|NA	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L- serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction
b0005	316407.21321895	1.4e-23	115.5	Escherichia	yaaX												Escherichia	1N4SV@1224,1S9KR@1236,2B58A@1,32XJS@2,3XRGB@561	NA|NA|NA	S	Protein of unknown function (DUF2502)
b0006	198214.SF0006	1.6e-143	515.4	Gammaproteobacteria													Escherichia	1MUAF@1224,1RMTD@1236,COG3022@1,COG3022@2	NA|NA|NA	S	Belongs to the UPF0246 family
b0007	316407.21321898	2.4e-267	927.5	Escherichia	yaaJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03310					ko00000	2.A.25		iEcE24377_1341.EcE24377A_0007	Escherichia	1MUI3@1224,1RMNF@1236,3XN15@561,COG1115@1,COG1115@2	NA|NA|NA	E	alanine:sodium symporter activity
b0008	198214.SF0009	2.5e-175	621.3	Gammaproteobacteria													Escherichia	1MWQ8@1224,1RMS0@1236,COG0176@1,COG0176@2	NA|NA|NA	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
b0009	155864.EDL933_0009	1.1e-104	386.0	Escherichia	mog	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0032324,GO:0034641,GO:0042278,GO:0042802,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.7.7.75	ko:K03831	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09726	RC00002	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1969,iECABU_c1320.ECABU_c00100,iECED1_1282.ECED1_0009,iECNA114_1301.ECNA114_4653,iECP_1309.ECP_0010,iECS88_1305.ECS88_0010,iECSF_1327.ECSF_0009,iECUMN_1333.ECUMN_0010,iEcSMS35_1347.EcSMS35_0008,iLF82_1304.LF82_1379,iNRG857_1313.NRG857_00050,iUMN146_1321.UM146_22820	Escherichia	1R9W2@1224,1RMZM@1236,3XMRI@561,COG0521@1,COG0521@2	NA|NA|NA	F	Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor
b0010	155864.EDL933_0010	2.9e-99	367.9	Escherichia	satP	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006835,GO:0006846,GO:0006855,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015078,GO:0015123,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015355,GO:0015360,GO:0015672,GO:0015711,GO:0015718,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0035433,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0043893,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071422,GO:0071702,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902600,GO:1903825,GO:1905039		ko:K07034					ko00000				Escherichia	1N3HP@1224,1RMRK@1236,3XNU9@561,COG1584@1,COG1584@2	NA|NA|NA	S	Uptake of acetate and succinate. Transport is energetically dependent on the protonmotive force
b0011	316407.85674280	3e-125	454.5	Escherichia	yaaW												Escherichia	1R4VH@1224,1S3Z6@1236,3XNA5@561,COG4735@1,COG4735@2	NA|NA|NA	S	Domain of unknown function (DUF3944)
b0013	316407.85674282	4.7e-67	260.4	Escherichia	yaaI												Escherichia	1RDBB@1224,1S5G0@1236,29AC0@1,2ZXCI@2,3XPSU@561	NA|NA|NA	S	Protein of unknown function (DUF2541)
b0014	1440052.EAKF1_ch1410c	0.0	1211.1	Escherichia	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141		ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1			Escherichia	1MVEN@1224,1RMDD@1236,3XM30@561,COG0443@1,COG0443@2	NA|NA|NA	O	Heat shock 70 kDa protein
b0015	316407.21321903	9.7e-179	632.9	Escherichia	dnaJ	GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141		ko:K03686					ko00000,ko03029,ko03110				Escherichia	1MVMS@1224,1RNHY@1236,3XMY8@561,COG0484@1,COG0484@2	NA|NA|NA	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
b0016	203275.BFO_0831	1.2e-210	738.8	Bacteria													Escherichia	COG3385@1,COG3385@2	NA|NA|NA	L	transposase activity
b4412	316407.21321904	2.8e-17	93.6	Gammaproteobacteria													Escherichia	1NHNZ@1224,1SGKV@1236,2EFY7@1,339QC@2	NA|NA|NA	S	PFAM Hok gef cell toxic protein
b0018	316407.21321904	1.3e-28	131.7	Gammaproteobacteria													Escherichia	1NHNZ@1224,1SGKV@1236,2EFY7@1,339QC@2	NA|NA|NA	S	PFAM Hok gef cell toxic protein
b0019	316407.21321905	1e-207	729.2	Escherichia	nhaA	GO:0003674,GO:0005215,GO:0005451,GO:0005488,GO:0005543,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006875,GO:0006883,GO:0006885,GO:0006950,GO:0006970,GO:0008150,GO:0008289,GO:0008324,GO:0009628,GO:0009651,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0035725,GO:0042592,GO:0043157,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051453,GO:0055065,GO:0055067,GO:0055078,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1901611,GO:1901612,GO:1902600		ko:K03313					ko00000,ko02000	2.A.33.1		iSF_1195.SF0016,iSFxv_1172.SFxv_0017,iS_1188.S0018	Escherichia	1MW15@1224,1RNDE@1236,3XMTC@561,COG3004@1,COG3004@2	NA|NA|NA	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
b0020	316407.85674285	3.2e-172	610.9	Escherichia	nhaR	GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K03717					ko00000,ko03000				Escherichia	1MVHT@1224,1RN7G@1236,3XPFK@561,COG0583@1,COG0583@2	NA|NA|NA	K	regulatory protein
b0021	177439.DP0860	5.6e-94	350.1	Proteobacteria													Escherichia	1NHAK@1224,COG1662@1,COG1662@2	NA|NA|NA	L	cog cog1662
b0022	1035839.AFNK01000018_gene1622	9e-46	189.1	Gammaproteobacteria													Escherichia	1NP8S@1224,1SDQB@1236,COG3677@1,COG3677@2	NA|NA|NA	L	PFAM Insertion element protein
b0023	1440052.EAKF1_ch1401	1.2e-36	158.7	Escherichia	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008073,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043086,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044092,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1990904		ko:K02968	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1MZ94@1224,1S9AI@1236,3XPV1@561,COG0268@1,COG0268@2	NA|NA|NA	J	Binds directly to 16S ribosomal RNA
b0024	316407.85674288	1.5e-32	144.8	Gammaproteobacteria													Escherichia	1NE6Q@1224,1SFJG@1236,2EFES@1,3397J@2	NA|NA|NA	S	cellular response to DNA damage stimulus
b0025	198214.SF0021	1.4e-175	622.1	Gammaproteobacteria													Escherichia	1MV9I@1224,1RN44@1236,COG0196@1,COG0196@2	NA|NA|NA	H	Belongs to the ribF family
b0026	316407.85674290	0.0	1935.2	Escherichia	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iG2583_1286.G2583_0027	Escherichia	1MVBQ@1224,1RMTF@1236,3XNGC@561,COG0060@1,COG0060@2	NA|NA|NA	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
b0027	316407.21321909	2e-88	331.6	Escherichia	lspA	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0042157,GO:0042158,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0097304,GO:0140096,GO:1901564,GO:1901566,GO:1901576	3.4.23.36	ko:K03101	ko03060,map03060				ko00000,ko00001,ko01000,ko01002				Escherichia	1RGV9@1224,1S60E@1236,3XP2H@561,COG0597@1,COG0597@2	NA|NA|NA	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
b0028	155864.EDL933_0027	2.2e-78	298.1	Escherichia	fkpB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0061077,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03774					ko00000,ko01000,ko03110				Escherichia	1RHD1@1224,1S5YP@1236,3XPMW@561,COG1047@1,COG1047@2	NA|NA|NA	O	with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide' where Xaa is the amino acid tested, was found to be Phe Leu Ile Lys Ala Trp His Gln
b0029	155864.EDL933_0028	1.6e-174	618.6	Escherichia	ispH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028	Escherichia	1MU7G@1224,1RMN8@1236,3XM3C@561,COG0761@1,COG0761@2	NA|NA|NA	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
b0030	316407.21321912	1.2e-171	609.0	Escherichia	rihC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045437,GO:0046483,GO:0046700,GO:0047622,GO:0047724,GO:0050263,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658		ko:K12700					ko00000,ko01000			iECNA114_1301.ECNA114_0014,iEcE24377_1341.EcE24377A_0030,iLF82_1304.LF82_1885,iNRG857_1313.NRG857_00145	Escherichia	1MUIW@1224,1RQ1V@1236,3XNKR@561,COG1957@1,COG1957@2	NA|NA|NA	F	Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity
b0031	316407.21321913	2.9e-148	531.2	Escherichia	dapB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000			iSbBS512_1146.SbBS512_E0035	Escherichia	1MUCT@1224,1RMCZ@1236,3XMUX@561,COG0289@1,COG0289@2	NA|NA|NA	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
b0032	155864.EDL933_0032	3.8e-223	780.4	Escherichia	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009987,GO:0016053,GO:0018130,GO:0019627,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040	Escherichia	1MUB9@1224,1RMAW@1236,3XMKS@561,COG0505@1,COG0505@2	NA|NA|NA	F	Carbamoyl-phosphate synthetase glutamine chain
b0033	316407.21321915	0.0	2105.9	Escherichia	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0017076,GO:0018130,GO:0019627,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_0034	Escherichia	1MUDZ@1224,1RPIU@1236,3XMVN@561,COG0458@1,COG0458@2	NA|NA|NA	F	Carbamoyl-phosphate synthetase ammonia chain
b0034	155864.EDL933_0035	1.9e-68	265.0	Escherichia				ko:K08277					ko00000,ko03000				Escherichia	1RJ32@1224,1S6GM@1236,2BXKV@1,32FV2@2,3XRGK@561	NA|NA|NA	K	CaiF/GrlA transcriptional regulator
b0035	316407.85674292	1.5e-98	365.5	Escherichia	caiE	GO:0003674,GO:0003824,GO:0006575,GO:0006577,GO:0006807,GO:0008150,GO:0008152,GO:0008735,GO:0009437,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0034641,GO:0044237,GO:0071704,GO:0097164,GO:1901564		ko:K08279					ko00000				Escherichia	1MVUI@1224,1RYPQ@1236,3XM7F@561,COG0663@1,COG0663@2	NA|NA|NA	S	Overproduction of CaiE stimulates the activity of CaiB and CaiD
b0036	316407.85674293	2.4e-144	518.1	Escherichia	caiD	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006575,GO:0006577,GO:0006579,GO:0006629,GO:0006631,GO:0006635,GO:0006807,GO:0008150,GO:0008152,GO:0008809,GO:0009056,GO:0009062,GO:0009437,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0034641,GO:0042219,GO:0042413,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575	4.2.1.149	ko:K08299			R10675	RC01095	ko00000,ko01000			iAPECO1_1312.APECO1_1945,iEC042_1314.EC042_0038,iECABU_c1320.ECABU_c00410,iECB_1328.ECB_00040,iECD_1391.ECD_00040,iECO103_1326.ECO103_0038,iECP_1309.ECP_0036,iETEC_1333.ETEC_0036,iNRG857_1313.NRG857_00190,iUMN146_1321.UM146_22960,ic_1306.c0045	Escherichia	1MWZC@1224,1RR3Z@1236,3XP09@561,COG1024@1,COG1024@2	NA|NA|NA	I	Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA
b0037	316407.21321919	4.3e-311	1072.8	Escherichia	caiC	GO:0003674,GO:0003824,GO:0016405,GO:0016874,GO:0016877,GO:0016879,GO:0016881,GO:0051108,GO:0051109	6.2.1.48	ko:K02182					ko00000,ko01000			iECSE_1348.ECSE_0038,iNRG857_1313.NRG857_00195	Escherichia	1MU6G@1224,1RMQ4@1236,3XMZB@561,COG0318@1,COG0318@2	NA|NA|NA	IQ	Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle
b0038	316407.21321920	1e-242	845.5	Escherichia	caiB	GO:0003674,GO:0003824,GO:0006575,GO:0006577,GO:0006579,GO:0006807,GO:0008150,GO:0008152,GO:0008735,GO:0009056,GO:0009437,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0034641,GO:0042219,GO:0042413,GO:0044237,GO:0044248,GO:0044270,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	2.8.3.21	ko:K08298			R10643,R10644	RC00014,RC00131	ko00000,ko01000			iEC55989_1330.EC55989_0038,iECIAI1_1343.ECIAI1_0040,iECO103_1326.ECO103_0040,iECO111_1330.ECO111_0039,iECO26_1355.ECO26_0039,iEcHS_1320.EcHS_A0042,iSF_1195.SF0035,iSFxv_1172.SFxv_0036,iS_1188.S0037	Escherichia	1MU2K@1224,1RNB5@1236,3XP57@561,COG1804@1,COG1804@2	NA|NA|NA	C	Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl- CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl- CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA
b0039	155864.EDL933_0040	2.5e-222	777.7	Escherichia	caiA		1.3.8.13	ko:K08297					ko00000,ko01000				Escherichia	1MUDR@1224,1RMMJ@1236,3XPD4@561,COG1960@1,COG1960@2	NA|NA|NA	I	Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA
b0040	316407.85674295	5.8e-296	1022.7	Escherichia	caiT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015226,GO:0015651,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0015879,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072349,GO:0072488,GO:0098655,GO:1902603		ko:K05245					ko00000,ko02000	2.A.15.2		iB21_1397.B21_00043,iECBD_1354.ECBD_3575,iECB_1328.ECB_00044,iECD_1391.ECD_00044,iSF_1195.SF0037,iSFxv_1172.SFxv_0038,iS_1188.S0039	Escherichia	1MV0K@1224,1RP3E@1236,3XNPU@561,COG1292@1,COG1292@2	NA|NA|NA	M	Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines
b0041	155864.EDL933_0042	7.7e-127	459.9	Escherichia	fixA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006575,GO:0006577,GO:0006579,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009437,GO:0009987,GO:0016491,GO:0022900,GO:0034641,GO:0042219,GO:0042413,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575		ko:K03521					ko00000				Escherichia	1MVH6@1224,1RN6F@1236,3XQE3@561,COG2086@1,COG2086@2	NA|NA|NA	C	Required for anaerobic carnitine reduction. May bring reductant to CaiA
b0042	316407.85674297	6.6e-173	613.2	Escherichia	fixB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006575,GO:0006577,GO:0006579,GO:0006629,GO:0006631,GO:0006635,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009437,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0034641,GO:0036094,GO:0042219,GO:0042413,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:0097164,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575		ko:K03522					ko00000,ko04147				Escherichia	1MUFI@1224,1RMK7@1236,3XM52@561,COG2025@1,COG2025@2	NA|NA|NA	C	Required for anaerobic carnitine reduction. May bring reductant to CaiA
b0043	199310.c0053	5.6e-239	833.2	Escherichia	fixC	GO:0006575,GO:0006577,GO:0006807,GO:0008150,GO:0008152,GO:0009437,GO:0009987,GO:0034641,GO:0044237,GO:0071704,GO:0097164,GO:1901564		ko:K00313					ko00000,ko01000				Escherichia	1MVU6@1224,1RNY5@1236,3XMZ6@561,COG0644@1,COG0644@2	NA|NA|NA	C	Could be part of an electron transfer system required for anaerobic carnitine reduction
b0044	155864.EDL933_0045	2.2e-50	204.5	Escherichia	fixX			ko:K03855					ko00000				Escherichia	1RHTX@1224,1S6EF@1236,3XPV6@561,COG2440@1,COG2440@2	NA|NA|NA	C	Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein
b0045	316407.85674300	5e-251	873.2	Escherichia	yaaU	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K08368					ko00000,ko02000	2.A.1			Escherichia	1QV3V@1224,1T27B@1236,3XN87@561,COG2271@1,COG2271@2	NA|NA|NA	P	response to oxidative stress
b0046	199310.c0056	9.7e-105	386.0	Escherichia	kefF	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0010181,GO:0016491,GO:0016651,GO:0016655,GO:0022898,GO:0022900,GO:0032409,GO:0032411,GO:0032412,GO:0032414,GO:0032553,GO:0032879,GO:0034762,GO:0034764,GO:0034765,GO:0034767,GO:0036094,GO:0043167,GO:0043168,GO:0043269,GO:0043270,GO:0044093,GO:0044237,GO:0048037,GO:0048518,GO:0050662,GO:0050789,GO:0051049,GO:0051050,GO:0055114,GO:0065007,GO:0065009,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K11746					ko00000,ko02000	2.A.37.1.1			Escherichia	1MXFT@1224,1RPAQ@1236,3XP8D@561,COG2249@1,COG2249@2	NA|NA|NA	C	Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC
b0047	316407.21321928	0.0	1158.3	Escherichia	kefC	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006885,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010033,GO:0015075,GO:0015077,GO:0015079,GO:0015291,GO:0015318,GO:0015503,GO:0015643,GO:0015672,GO:0016020,GO:0016021,GO:0019899,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051595,GO:0055067,GO:0055080,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1901654,GO:1901700		ko:K11745					ko00000,ko02000	2.A.37.1.1		iECOK1_1307.ECOK1_0046,iECS88_1305.ECS88_0050,iUMN146_1321.UM146_23015,iUTI89_1310.UTI89_C0053	Escherichia	1MV34@1224,1RNVR@1236,3XN4I@561,COG0475@1,COG0475@2,COG1226@1,COG1226@2	NA|NA|NA	P	Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K( ) H( ) antiport
b0048	198214.SF0045	2.3e-89	334.7	Gammaproteobacteria													Escherichia	1RH0P@1224,1S5VH@1236,COG0262@1,COG0262@2	NA|NA|NA	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
b0049	316407.85674302	4.4e-168	597.0	Escherichia	apaH	GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564	3.6.1.41	ko:K01525	ko00230,map00230		R00125	RC00002	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_0052,iEcSMS35_1347.EcSMS35_0053,iSDY_1059.SDY_0074	Escherichia	1MV10@1224,1RPUJ@1236,3XMZF@561,COG0639@1,COG0639@2	NA|NA|NA	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
b0050	155864.EDL933_0053	3.7e-66	257.3	Escherichia	apaG			ko:K06195					ko00000				Escherichia	1MZ2Z@1224,1S8SE@1236,3XPM5@561,COG2967@1,COG2967@2	NA|NA|NA	P	ApaG domain
b0051	316407.85674303	1.9e-152	545.0	Escherichia	ksgA	GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.182	ko:K02528			R10716	RC00003,RC03257	ko00000,ko01000,ko03009				Escherichia	1MVNU@1224,1RMHW@1236,3XMDQ@561,COG0030@1,COG0030@2	NA|NA|NA	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
b0052	316407.21321932	3.2e-186	657.5	Escherichia	pdxA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000			iECO111_1330.ECO111_0056	Escherichia	1MX5W@1224,1RNZV@1236,3XMAU@561,COG1995@1,COG1995@2	NA|NA|NA	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
b0053	155864.EDL933_0056	7.5e-236	822.8	Escherichia	surA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564	5.2.1.8	ko:K03771					ko00000,ko01000,ko03110				Escherichia	1MVB3@1224,1RMWU@1236,3XP9E@561,COG0760@1,COG0760@2	NA|NA|NA	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
b0054	316407.21321935	0.0	1610.5	Escherichia	lptD	GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:1901264		ko:K04744					ko00000,ko02000	1.B.42.1		iG2583_1286.G2583_0058	Escherichia	1MUJC@1224,1RQEX@1236,3XN2D@561,COG1452@1,COG1452@2	NA|NA|NA	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
b0055	316407.21321936	4.9e-148	530.4	Escherichia	djlA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944		ko:K05801					ko00000,ko03110				Escherichia	1N270@1224,1RP0P@1236,3XMH7@561,COG1076@1,COG1076@2	NA|NA|NA	O	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host
b0056	316407.85674305	3.5e-112	411.0	Bacteria													Escherichia	COG1357@1,COG1357@2	NA|NA|NA	S	protein homooligomerization
b0058	316407.85674306	6.1e-125	453.4	Escherichia	rluA	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.28,5.4.99.29	ko:K06177					ko00000,ko01000,ko03009,ko03016				Escherichia	1MVJ5@1224,1RN4N@1236,3XNBC@561,COG0564@1,COG0564@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil
b0059	155864.EDL933_0061	0.0	1918.7	Escherichia	rapA	GO:0001000,GO:0003674,GO:0003676,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043175,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03580					ko00000,ko01000,ko03021				Escherichia	1MX6H@1224,1RNRZ@1236,3XNHH@561,COG0553@1,COG0553@2	NA|NA|NA	K	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
b0060	316407.85674307	0.0	1633.6	Escherichia	polB	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02336					ko00000,ko01000,ko03400				Escherichia	1MVY9@1224,1RMQ1@1236,3XPER@561,COG0417@1,COG0417@2	NA|NA|NA	L	DNA polymerase
b0061	316407.21321943	4.2e-132	477.2	Escherichia	araD	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008742,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019324,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000			iSSON_1240.SSON_0067	Escherichia	1MU54@1224,1RMIP@1236,3XMI6@561,COG0235@1,COG0235@2	NA|NA|NA	G	Belongs to the aldolase class II family. AraD FucA subfamily
b0062	316407.85674308	2.4e-302	1043.9	Escherichia	araA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008733,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100		R01761	RC00516	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1922,iB21_1397.B21_00063,iBWG_1329.BWG_0058,iE2348C_1286.E2348C_0063,iECBD_1354.ECBD_3555,iECD_1391.ECD_00064,iECED1_1282.ECED1_0061,iECIAI1_1343.ECIAI1_0062,iECNA114_1301.ECNA114_0050,iECO103_1326.ECO103_0063,iECO26_1355.ECO26_0064,iECOK1_1307.ECOK1_0061,iECP_1309.ECP_0063,iECS88_1305.ECS88_0065,iECSE_1348.ECSE_0062,iECW_1372.ECW_m0060,iEKO11_1354.EKO11_3852,iEcE24377_1341.EcE24377A_0064,iEcHS_1320.EcHS_A0066,iEcSMS35_1347.EcSMS35_0064,iEcolC_1368.EcolC_3595,iLF82_1304.LF82_0105,iNRG857_1313.NRG857_00320,iSBO_1134.SBO_0049,iSSON_1240.SSON_0068,iUMN146_1321.UM146_23095,iUTI89_1310.UTI89_C0067,iWFL_1372.ECW_m0060	Escherichia	1MW0J@1224,1RQEF@1236,3XN18@561,COG2160@1,COG2160@2	NA|NA|NA	G	Catalyzes the conversion of L-arabinose to L-ribulose
b0063	316407.85674309	0.0	1148.3	Escherichia	araB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008741,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0046373,GO:0046835,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	2.7.1.16	ko:K00853	ko00040,ko01100,map00040,map01100		R01526,R02439	RC00002,RC00538	ko00000,ko00001,ko01000			iBWG_1329.BWG_0059,iECH74115_1262.ECH74115_0068,iECSP_1301.ECSP_0067,iECs_1301.ECs0067,iG2583_1286.G2583_0066,iZ_1308.Z0072	Escherichia	1MY11@1224,1RP3F@1236,3XNYZ@561,COG1069@1,COG1069@2	NA|NA|NA	F	Belongs to the ribulokinase family
b0064	155864.EDL933_0066	4.7e-173	613.6	Escherichia	araC	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016052,GO:0019219,GO:0019222,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046365,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901575,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02099					ko00000,ko03000				Escherichia	1MVS8@1224,1RQ3Y@1236,3XPF8@561,COG4977@1,COG4977@2	NA|NA|NA	K	This protein controls the expression of at least six genes that are involved in the transport and catabolism of L- arabinose. It regulates initiation of transcription of the araBAD operon and it also controls its own synthesis. The L-arabinose operon displays both positive and negative regulation through AraC
b0065	316407.85674310	7.1e-141	506.5	Escherichia	yabI	GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0032505,GO:0043093,GO:0044464,GO:0050896,GO:0051301,GO:0071944											Escherichia	1R0F3@1224,1RPDS@1236,3XN37@561,COG0586@1,COG0586@2	NA|NA|NA	S	reproductive process
b0066	316407.85674311	8e-123	446.4	Escherichia	thiQ	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0006855,GO:0008144,GO:0008150,GO:0015234,GO:0015238,GO:0015893,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035461,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0045117,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071934,GO:0072348,GO:0072531,GO:0090482,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901474,GO:1901682		ko:K02062	ko02010,map02010	M00191			ko00000,ko00001,ko00002,ko02000	3.A.1.19		iAF1260.b0066,iEC55989_1330.EC55989_0064,iECABU_c1320.ECABU_c00740,iECDH1ME8569_1439.ECDH1ME8569_0065,iECO103_1326.ECO103_0067,iECO111_1330.ECO111_0068,iECO26_1355.ECO26_0068,iECSE_1348.ECSE_0066,iETEC_1333.ETEC_0065,iEcDH1_1363.EcDH1_3533,iJO1366.b0066,iJR904.b0066,iUMNK88_1353.UMNK88_64,iY75_1357.Y75_RS00335,ic_1306.c0082	Escherichia	1MV78@1224,1RQH3@1236,3XNBK@561,COG3840@1,COG3840@2	NA|NA|NA	P	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
b0067	316407.85674312	5.6e-297	1026.2	Escherichia	thiP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015234,GO:0015238,GO:0015893,GO:0016020,GO:0022857,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071934,GO:0071944,GO:0072348,GO:0072531,GO:0090482,GO:1901474,GO:1901682		ko:K02063	ko02010,map02010	M00191			ko00000,ko00001,ko00002,ko02000	3.A.1.19		iAPECO1_1312.APECO1_1915,iECIAI1_1343.ECIAI1_0067,iECO103_1326.ECO103_0068,iECO111_1330.ECO111_0069,iECO26_1355.ECO26_0069,iECOK1_1307.ECOK1_0068,iECS88_1305.ECS88_0072,iECSE_1348.ECSE_0067,iECUMN_1333.ECUMN_0068,iSF_1195.SF0062,iSFxv_1172.SFxv_0064,iS_1188.S0064,iUMN146_1321.UM146_23130,iUTI89_1310.UTI89_C0075	Escherichia	1MWCF@1224,1RNHK@1236,3XPBK@561,COG1178@1,COG1178@2	NA|NA|NA	P	transport system permease protein
b0068	316407.85674313	1.3e-187	662.1	Escherichia	tbpA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008144,GO:0008150,GO:0015888,GO:0015893,GO:0019842,GO:0030288,GO:0030313,GO:0030975,GO:0030976,GO:0031975,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0045117,GO:0048037,GO:0050662,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0071702,GO:0071705,GO:0072348,GO:0097159,GO:1901363,GO:1901681		ko:K02064	ko02010,map02010	M00191			ko00000,ko00001,ko00002,ko02000	3.A.1.19		iAPECO1_1312.APECO1_1914,iSFxv_1172.SFxv_0065,iUTI89_1310.UTI89_C0076	Escherichia	1MUBB@1224,1RMQ9@1236,3XNCI@561,COG4143@1,COG4143@2	NA|NA|NA	P	Periplasmic protein
b0069	316407.85674314	0.0	1153.7	Escherichia	sgrR	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005623,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031975,GO:0042597,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K11925					ko00000,ko03000				Escherichia	1N2NK@1224,1RP2Z@1236,3XM3Y@561,COG4533@1,COG4533@2	NA|NA|NA	K	Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain
b4662	469008.B21_04251	4.9e-18	95.9	Escherichia	sgrT	GO:0003674,GO:0004857,GO:0008150,GO:0010827,GO:0010829,GO:0030234,GO:0032879,GO:0034762,GO:0034763,GO:0043086,GO:0044092,GO:0046324,GO:0046325,GO:0048519,GO:0050789,GO:0050790,GO:0051049,GO:0051051,GO:0065007,GO:0065009,GO:0098772											Escherichia	1QIS6@1224,1TGMJ@1236,2AV6G@1,31KWV@2,3XRB6@561	NA|NA|NA	C	Inhibitor of glucose uptake transporter SgrT
b0070	316407.85674315	1.2e-211	742.3	Escherichia	setA	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006950,GO:0008150,GO:0008643,GO:0009987,GO:0015766,GO:0015767,GO:0015772,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0036447,GO:0036448,GO:0044425,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071702,GO:0071944		ko:K03291					ko00000,ko02000	2.A.1.20		iECDH1ME8569_1439.ECDH1ME8569_0068	Escherichia	1MWWU@1224,1RN2I@1236,3XP9H@561,COG0477@1,COG2814@2	NA|NA|NA	P	Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport IPTG, lactose and glucose. Has broad substrate specificity, with preferences for glucosides or galactosides with alkyl or aryl substituents
b0071	316407.21321953	1.4e-115	422.2	Escherichia	leuD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000				Escherichia	1MVXB@1224,1RNMK@1236,3XN6D@561,COG0066@1,COG0066@2	NA|NA|NA	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
b0072	199310.c0089	8.7e-270	935.6	Escherichia	leuC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016853,GO:0016866,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000			iEcE24377_1341.EcE24377A_0075	Escherichia	1MVYR@1224,1RMF6@1236,3XN9T@561,COG0065@1,COG0065@2	NA|NA|NA	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
b0073	316407.21321955	6.2e-207	726.5	Escherichia	leuB	GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000			iECs_1301.ECs0077,iZ_1308.Z0082	Escherichia	1MUH4@1224,1RMZQ@1236,3XNII@561,COG0473@1,COG0473@2	NA|NA|NA	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
b0074	316407.85674317	2.2e-293	1014.2	Escherichia	leuA	GO:0003674,GO:0003824,GO:0003852,GO:0003985,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046912,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000			iSFV_1184.SFV_0066	Escherichia	1MUNQ@1224,1RMWE@1236,3XNCN@561,COG0119@1,COG0119@2	NA|NA|NA	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
b0076	316407.85674318	9e-178	629.4	Escherichia	leuO	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0032993,GO:0043565,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K05798					ko00000,ko03000			iECW_1372.ECW_m0076,iWFL_1372.ECW_m0076	Escherichia	1MX24@1224,1RQP0@1236,3XM7V@561,COG0583@1,COG0583@2	NA|NA|NA	K	uxaCA, sdaCB and yjiY. H-NS repression of the bgl operon, leading to the ability to metabolize some beta-glucosides. It also directly activates the bgl operon. Activation is H-NS and BglJ-RcsB independent
b0077	316407.85674319	0.0	1154.8	Escherichia	ilvI	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085	Escherichia	1MU6U@1224,1RMQQ@1236,3XNV1@561,COG0028@1,COG0028@2	NA|NA|NA	H	acetolactate synthase activity
b0078	316407.85674320	3.1e-81	307.8	Escherichia	ilvH	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iEcSMS35_1347.EcSMS35_0084	Escherichia	1RAGN@1224,1S20I@1236,3XP6U@561,COG0440@1,COG0440@2	NA|NA|NA	E	acetolactate synthase
b0080	155864.EDL933_0083	2.1e-188	664.8	Escherichia	fruR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016052,GO:0016053,GO:0016310,GO:0017144,GO:0018130,GO:0019219,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031326,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051186,GO:0051188,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03435					ko00000,ko03000				Escherichia	1MXQ1@1224,1RNR1@1236,3XN1T@561,COG1609@1,COG1609@2	NA|NA|NA	K	Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism
b0081	316407.21321962	2.9e-81	307.8	Escherichia	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141		ko:K03925					ko00000				Escherichia	1RHCG@1224,1S63F@1236,3XPDS@561,COG2001@1,COG2001@2	NA|NA|NA	K	Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster
b0082	155864.EDL933_0085	3e-173	614.4	Escherichia	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438					ko00000,ko01000,ko03009				Escherichia	1MUT4@1224,1RM7M@1236,3XNTS@561,COG0275@1,COG0275@2	NA|NA|NA	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA
b0083	1440052.EAKF1_ch1338c	2.5e-59	234.6	Escherichia	ftsL	GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0019954,GO:0022402,GO:0022414,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0043093,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944		ko:K03586					ko00000,ko03036				Escherichia	1N9MH@1224,1SC7P@1236,3XPMD@561,COG3116@1,COG3116@2	NA|NA|NA	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
b0084	155864.EDL933_0087	0.0	1157.9	Escherichia	ftsI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501				ko00000,ko00001,ko01000,ko01011,ko03036			iSSON_1240.SSON_0092	Escherichia	1MUNY@1224,1RNGW@1236,3XM4D@561,COG0768@1,COG0768@2	NA|NA|NA	M	of the peptidoglycan cell wall at the division septum
b0085	316407.21321966	3.7e-287	993.4	Escherichia	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550		R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011			iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103	Escherichia	1MU6P@1224,1RMD6@1236,3XNJS@561,COG0769@1,COG0769@2	NA|NA|NA	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
b0086	316407.85674322	3.7e-249	867.1	Escherichia	murF	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008766,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0047480,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502		R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iB21_1397.B21_00086,iEC042_1314.EC042_0087,iEC55989_1330.EC55989_0082,iECBD_1354.ECBD_3531,iECB_1328.ECB_00087,iECD_1391.ECD_00087,iECIAI1_1343.ECIAI1_0085,iECO103_1326.ECO103_0088,iECO111_1330.ECO111_0089,iECO26_1355.ECO26_0089,iECSE_1348.ECSE_0088,iECW_1372.ECW_m0085,iEKO11_1354.EKO11_3828,iEcE24377_1341.EcE24377A_0088,iEcHS_1320.EcHS_A0092,iEcolC_1368.EcolC_3571,iSBO_1134.SBO_0074,iSSON_1240.SSON_0094,iSbBS512_1146.SbBS512_E0079,iUMNK88_1353.UMNK88_86,iWFL_1372.ECW_m0085	Escherichia	1QTSF@1224,1RMGD@1236,3XMEK@561,COG0770@1,COG0770@2	NA|NA|NA	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
b0087	198214.SF0084	1e-201	709.1	Gammaproteobacteria													Escherichia	1MUTK@1224,1RNIG@1236,COG0472@1,COG0472@2	NA|NA|NA	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
b0088	316407.21321969	2.1e-249	867.8	Escherichia	murD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100		R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097	Escherichia	1MVYD@1224,1RP25@1236,3XM3E@561,COG0771@1,COG0771@2	NA|NA|NA	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
b0089	155864.EDL933_0092	2.1e-227	794.7	Escherichia	ftsW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505		ko:K03588	ko04112,map04112				ko00000,ko00001,ko02000,ko03036	2.A.103.1			Escherichia	1MVDB@1224,1RMIV@1236,3XMYW@561,COG0772@1,COG0772@2	NA|NA|NA	D	Peptidoglycan polymerase that is essential for cell division
b0090	316407.21321971	3.6e-199	700.7	Escherichia	murG	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112		R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011		GT28	iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089	Escherichia	1MVIB@1224,1RMQ3@1236,3XNRS@561,COG0707@1,COG0707@2	NA|NA|NA	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
b0091	316407.21321972	2.5e-283	980.7	Escherichia	murC	GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100		R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iECP_1309.ECP_0093	Escherichia	1MV68@1224,1RN88@1236,3XP40@561,COG0773@1,COG0773@2	NA|NA|NA	M	Belongs to the MurCDEF family
b0092	316407.21321973	2e-169	601.7	Escherichia	ddlB	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iECO26_1355.ECO26_0095	Escherichia	1MUTB@1224,1RMTM@1236,3XMQE@561,COG1181@1,COG1181@2	NA|NA|NA	F	Belongs to the D-alanine--D-alanine ligase family
b0093	316407.21321974	3e-153	547.7	Escherichia	ftsQ	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047		ko:K03589	ko04112,map04112				ko00000,ko00001,ko03036				Escherichia	1N0T7@1224,1S9FJ@1236,3XPDZ@561,COG1589@1,COG1589@2	NA|NA|NA	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
b0094	155864.EDL933_0097	1.9e-236	824.7	Escherichia	ftsA	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363		ko:K03590	ko04112,map04112				ko00000,ko00001,ko03036,ko04812				Escherichia	1MUSR@1224,1RMXY@1236,3XNPQ@561,COG0849@1,COG0849@2	NA|NA|NA	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
b0095	155864.EDL933_0098	7.8e-208	729.6	Escherichia	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03531	ko04112,map04112				ko00000,ko00001,ko02048,ko03036,ko04812				Escherichia	1MV2X@1224,1RPZS@1236,3XPCM@561,COG0206@1,COG0206@2	NA|NA|NA	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
b0096	155864.EDL933_0099	1.3e-173	615.5	Escherichia	lpxC	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005			iECS88_1305.ECS88_0100	Escherichia	1MV6T@1224,1RQ72@1236,3XP96@561,COG0774@1,COG0774@2	NA|NA|NA	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
b0097	198214.SF0094	8.2e-93	346.3	Gammaproteobacteria													Escherichia	1RC3K@1224,1S7VM@1236,2ATX7@1,31JGK@2	NA|NA|NA	S	Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation
b0098	316407.85674325	0.0	1708.7	Escherichia	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680		ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4			Escherichia	1MUJZ@1224,1RM9M@1236,3XN2C@561,COG0653@1,COG0653@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
b0099	316407.21321980	1.5e-70	271.9	Escherichia	mutT	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008413,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0030145,GO:0033554,GO:0034641,GO:0035539,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044715,GO:0044716,GO:0046483,GO:0046872,GO:0046914,GO:0047429,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.6.1.55	ko:K03574					ko00000,ko01000,ko03400			iE2348C_1286.E2348C_0104,iSDY_1059.SDY_0129	Escherichia	1RCZM@1224,1RS3S@1236,3XPPA@561,COG0494@1,COG0494@2	NA|NA|NA	L	Belongs to the Nudix hydrolase family
b0101	155864.EDL933_0103	1.2e-31	141.7	Escherichia	yacG	GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372		ko:K09862					ko00000				Escherichia	1NGJ8@1224,1SC7M@1236,3XPZW@561,COG3024@1,COG3024@2	NA|NA|NA	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
b0102	316407.85674327	1.1e-138	499.2	Escherichia	yacF	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044424,GO:0044444,GO:0044464,GO:0051301		ko:K18778					ko00000,ko03036				Escherichia	1MW69@1224,1RNPD@1236,3XMAW@561,COG4582@1,COG4582@2	NA|NA|NA	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
b0103	155864.EDL933_0105	1.1e-107	396.0	Escherichia	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_0104	Escherichia	1RCXT@1224,1S3NR@1236,3XMTW@561,COG0237@1,COG0237@2	NA|NA|NA	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
b0104	199310.c0124	1.4e-195	688.7	Escherichia	guaC	GO:0003674,GO:0003824,GO:0003920,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015949,GO:0015950,GO:0015951,GO:0016491,GO:0016651,GO:0016657,GO:0019637,GO:0019693,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.7.1.7	ko:K00364	ko00230,map00230		R01134	RC00457	ko00000,ko00001,ko01000			iEC042_1314.EC042_0103,iECIAI39_1322.ECIAI39_0105,iECUMN_1333.ECUMN_0102	Escherichia	1MUJM@1224,1RPZY@1236,3XNMG@561,COG0516@1,COG0516@2	NA|NA|NA	F	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
b0106	316407.85674330	1.5e-222	778.5	Escherichia	hofC	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776		ko:K02505					ko00000,ko02044				Escherichia	1MV4U@1224,1RNV0@1236,3XMGZ@561,COG1459@1,COG1459@2	NA|NA|NA	U	protein transport across the cell outer membrane
b0107	316407.85674331	2.6e-266	924.1	Escherichia	hofB			ko:K02504					ko00000,ko02044				Escherichia	1MU7V@1224,1RMBS@1236,3XMC0@561,COG2804@1,COG2804@2	NA|NA|NA	NU	ATP binding
b0108	316407.85674332	3.2e-77	294.3	Escherichia	ppdD	GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464		ko:K02682					ko00000,ko02044				Escherichia	1N7EQ@1224,1SCES@1236,3XPNR@561,COG4969@1,COG4969@2	NA|NA|NA	NU	Prokaryotic N-terminal methylation motif
b0109	316407.85674333	3.7e-165	587.4	Escherichia	nadC	GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_0109	Escherichia	1MW0C@1224,1RMBU@1236,3XPB2@561,COG0157@1,COG0157@2	NA|NA|NA	F	Belongs to the NadC ModD family
b0110	316407.21238958	6.7e-109	399.8	Escherichia	ampD	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043170,GO:0044424,GO:0044464,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.5.1.28	ko:K03806					ko00000,ko01000,ko01011			iAF1260.b0110,iB21_1397.B21_00108,iBWG_1329.BWG_0103,iEC55989_1330.EC55989_0103,iECBD_1354.ECBD_3509,iECB_1328.ECB_00109,iECDH10B_1368.ECDH10B_0090,iECDH1ME8569_1439.ECDH1ME8569_0104,iECD_1391.ECD_00109,iECIAI1_1343.ECIAI1_0107,iECO103_1326.ECO103_0110,iECO111_1330.ECO111_0111,iECO26_1355.ECO26_0112,iECSE_1348.ECSE_0110,iECW_1372.ECW_m0107,iEKO11_1354.EKO11_3806,iETEC_1333.ETEC_0106,iEcDH1_1363.EcDH1_3492,iEcE24377_1341.EcE24377A_0112,iEcHS_1320.EcHS_A0114,iEcolC_1368.EcolC_3549,iJO1366.b0110,iSFV_1184.SFV_0101,iSF_1195.SF0107,iSFxv_1172.SFxv_0113,iS_1188.S0109,iUMNK88_1353.UMNK88_108,iWFL_1372.ECW_m0107,iY75_1357.Y75_RS00560	Escherichia	1RDHU@1224,1S3PG@1236,3XN89@561,COG3023@1,COG3023@2	NA|NA|NA	V	Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha- amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety (By similarity)
b0111	198214.SF0108	2.1e-157	561.6	Gammaproteobacteria													Escherichia	1MVMK@1224,1RQTI@1236,COG3725@1,COG3725@2	NA|NA|NA	V	regulatory protein AmpE
b0112	316407.85674334	2.1e-252	877.9	Escherichia	aroP	GO:0003333,GO:0003674,GO:0005215,GO:0005302,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008104,GO:0008150,GO:0008320,GO:0008324,GO:0008509,GO:0008514,GO:0008565,GO:0009977,GO:0015031,GO:0015075,GO:0015171,GO:0015173,GO:0015179,GO:0015192,GO:0015196,GO:0015238,GO:0015291,GO:0015318,GO:0015399,GO:0015405,GO:0015450,GO:0015711,GO:0015801,GO:0015807,GO:0015823,GO:0015827,GO:0015828,GO:0015833,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0033036,GO:0034220,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1904680,GO:1905039		ko:K11734					ko00000,ko02000	2.A.3.1.3		iEcE24377_1341.EcE24377A_0114	Escherichia	1MUPS@1224,1RNK0@1236,3XM6P@561,COG1113@1,COG1113@2	NA|NA|NA	U	Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan)
b0113	155864.EDL933_0114	1.9e-133	481.9	Escherichia	pdhR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K05799					ko00000,ko03000				Escherichia	1MUP9@1224,1RNPJ@1236,3XPBN@561,COG2186@1,COG2186@2	NA|NA|NA	K	Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd
b0114	155864.EDL933_0116	0.0	1810.8	Escherichia	aceE	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000			e_coli_core.b0114,iAF1260.b0114,iBWG_1329.BWG_0107,iE2348C_1286.E2348C_0117,iEC55989_1330.EC55989_0107,iECDH10B_1368.ECDH10B_0094,iECDH1ME8569_1439.ECDH1ME8569_0108,iECH74115_1262.ECH74115_0121,iECIAI1_1343.ECIAI1_0112,iECNA114_1301.ECNA114_0106,iECO103_1326.ECO103_0114,iECO111_1330.ECO111_0115,iECO26_1355.ECO26_0116,iECSE_1348.ECSE_0114,iECSF_1327.ECSF_0127,iECSP_1301.ECSP_0115,iECUMN_1333.ECUMN_0111,iECW_1372.ECW_m0111,iECs_1301.ECs0118,iEKO11_1354.EKO11_3802,iETEC_1333.ETEC_0110,iEcDH1_1363.EcDH1_3488,iEcE24377_1341.EcE24377A_0116,iEcHS_1320.EcHS_A0118,iEcSMS35_1347.EcSMS35_0124,iEcolC_1368.EcolC_3545,iG2583_1286.G2583_0118,iJO1366.b0114,iJR904.b0114,iUMNK88_1353.UMNK88_112,iWFL_1372.ECW_m0111,iY75_1357.Y75_RS00580,iZ_1308.Z0124	Escherichia	1MV21@1224,1RN6K@1236,3XP9X@561,COG2609@1,COG2609@2	NA|NA|NA	F	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
b0115	316407.21238964	3.7e-300	1036.9	Escherichia	aceF	GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000			iETEC_1333.ETEC_0111,iSSON_1240.SSON_0123	Escherichia	1MU7K@1224,1RNPT@1236,3XP11@561,COG0508@1,COG0508@2	NA|NA|NA	F	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
b0116	155864.EDL933_0118	9.4e-272	942.2	Escherichia	lpdA	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006090,GO:0006103,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0015036,GO:0016054,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017144,GO:0019464,GO:0019752,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147			iEcolC_1368.EcolC_3543	Escherichia	1MU2U@1224,1RMFF@1236,3XM8F@561,COG1249@1,COG1249@2	NA|NA|NA	F	Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes
b0117	316407.85674338	6.1e-247	860.1	Escherichia	yacH												Escherichia	1MXPS@1224,1RQIV@1236,3XNHJ@561,COG3064@1,COG3064@2	NA|NA|NA	M	Protein of unknown function (DUF3300)
b0118	316407.85674339	0.0	1738.0	Escherichia	acnB	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006417,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009062,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019222,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032787,GO:0034248,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046395,GO:0046459,GO:0046487,GO:0047456,GO:0048037,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0072329,GO:0072350,GO:0080090,GO:0097159,GO:1901363,GO:1901575,GO:2000112	4.2.1.3,4.2.1.99	ko:K01682	ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173	R01324,R01325,R01900,R04425	RC00497,RC00498,RC00618,RC01153	br01601,ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_0116	Escherichia	1MVCR@1224,1RNMC@1236,3XP43@561,COG1049@1,COG1049@2	NA|NA|NA	C	Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Also catalyzes the hydration of 2-methyl-cis- aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein. During oxidative stress inactive AcnB apo-enzyme without iron sulfur clusters binds the acnB mRNA 3' UTRs (untranslated regions), stabilizes acnB mRNA and increases AcnB synthesis, thus mediating a post-transcriptional positive autoregulatory switch. AcnB also decreases the stability of the sodA transcript
b0119	155864.EDL933_0121	2.1e-63	248.1	Escherichia	yacL			ko:K09910					ko00000				Escherichia	1RH38@1224,1S6EG@1236,3XPS8@561,COG3112@1,COG3112@2	NA|NA|NA	S	Belongs to the UPF0231 family
b0120	155864.EDL933_0122	9.3e-152	542.7	Escherichia	speD	GO:0003674,GO:0003824,GO:0004014,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_0027	Escherichia	1MXPT@1224,1RQSX@1236,3XMVM@561,COG1586@1,COG1586@2	NA|NA|NA	F	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
b0121	316407.21238974	1.1e-169	602.4	Escherichia	speE	GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043918,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_0125,iSDY_1059.SDY_0028	Escherichia	1MVV5@1224,1RMUT@1236,3XPDB@561,COG0421@1,COG0421@2	NA|NA|NA	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
b0122	155864.EDL933_0124	9e-59	232.6	Escherichia	yacC												Escherichia	1RH3T@1224,1S639@1236,2B1X9@1,31UDJ@2,3XPRS@561	NA|NA|NA	S	Type II secretion system pilotin lipoprotein (PulS_OutS)
b0123	316407.85674340	7.6e-291	1005.7	Escherichia	cueO	GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0006950,GO:0008150,GO:0008152,GO:0009636,GO:0010035,GO:0010038,GO:0010273,GO:0016491,GO:0016679,GO:0016682,GO:0016722,GO:0016724,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0055114,GO:0061687,GO:0097501,GO:0098754,GO:1990169		ko:K14588					ko00000			iECH74115_1262.ECH74115_0130,iECSP_1301.ECSP_0124,iSbBS512_1146.SbBS512_E0116	Escherichia	1MU0J@1224,1RQ4N@1236,3XNI6@561,COG2132@1,COG2132@2	NA|NA|NA	Q	Probably involved in periplasmic detoxification of copper by oxidizing Cu( ) to Cu(2 ) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm
b0124	316407.21238978	0.0	1543.5	Escherichia	gcd	GO:0000287,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005575,GO:0008150,GO:0008152,GO:0008876,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0031224,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044425,GO:0046872,GO:0048037,GO:0048038,GO:0048039,GO:0055114,GO:0070968,GO:0097159,GO:1901363	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130		R06620	RC00066	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_0117,iECIAI1_1343.ECIAI1_0122,iECW_1372.ECW_m0121,iEKO11_1354.EKO11_3792,iWFL_1372.ECW_m0121	Escherichia	1MUQX@1224,1RN5D@1236,3XPH2@561,COG4993@1,COG4993@2	NA|NA|NA	G	Glucose dehydrogenase
b0125	155864.EDL933_0128	1e-93	349.4	Escherichia	hpt	GO:0000287,GO:0003674,GO:0003824,GO:0004422,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043167,GO:0043169,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110		R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000				Escherichia	1NRT8@1224,1RNPQ@1236,3XP65@561,COG0634@1,COG0634@2	NA|NA|NA	F	Belongs to the purine pyrimidine phosphoribosyltransferase family
b0126	198214.SF0123	3.5e-128	464.2	Gammaproteobacteria													Escherichia	1NGFN@1224,1RSY6@1236,COG0288@1,COG0288@2	NA|NA|NA	P	Reversible hydration of carbon dioxide
b0127	316407.21238982	5.7e-169	600.1	Escherichia	yadG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K01990		M00254			ko00000,ko00002,ko02000	3.A.1			Escherichia	1MUW7@1224,1RMC5@1236,3XMIT@561,COG1131@1,COG1131@2	NA|NA|NA	V	ABC transporter, ATP-binding protein
b0128	198214.SF0125	6.7e-139	500.0	Gammaproteobacteria													Escherichia	1MUH1@1224,1RP0Z@1236,COG0842@1,COG0842@2	NA|NA|NA	V	Transport Permease Protein
b0129	316407.85674344	1.8e-80	305.1	Escherichia	yadI												Escherichia	1RA6P@1224,1S2FN@1236,3XPNF@561,COG2893@1,COG2893@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane
b0130	316407.85674345	6.5e-237	826.2	Escherichia	yadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016810,GO:0016814,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MWR2@1224,1RP7J@1236,3XP5Q@561,COG0726@1,COG0726@2	NA|NA|NA	G	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
b0131	155864.EDL933_0134	2.4e-65	254.6	Escherichia	panD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0016485,GO:0016540,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_0139	Escherichia	1RI1B@1224,1S66E@1236,3XPIJ@561,COG0853@1,COG0853@2	NA|NA|NA	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
b0132	316407.85674347	2.8e-152	544.7	Escherichia	yadD	GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360											Escherichia	1MUSP@1224,1RNUW@1236,3XQBX@561,COG5464@1,COG5464@2	NA|NA|NA	L	Upon expression enhances RecA-independent DNA recombination 2.9-fold, concomitantly reducing viability by 59 and inducing DNA damage as measured by induction of the SOS repair response
b0133	316407.85674348	1.6e-154	552.0	Escherichia	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_0142,iECSP_1301.ECSP_0134,iECs_1301.ECs0137,iG2583_1286.G2583_0137,iZ_1308.Z0144	Escherichia	1MV1S@1224,1RMEG@1236,3XMDV@561,COG0414@1,COG0414@2	NA|NA|NA	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
b0134	316407.21238990	8.4e-145	519.6	Escherichia	panB	GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_00132,iE2348C_1286.E2348C_0137,iECBD_1354.ECBD_3485,iECB_1328.ECB_00133,iECD_1391.ECD_00133	Escherichia	1MU3B@1224,1RM8D@1236,3XNWS@561,COG0413@1,COG0413@2	NA|NA|NA	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
b0135	316407.21238991	1.3e-240	838.6	Bacteria													Escherichia	COG3539@1,COG3539@2	NA|NA|NA	NU	cell adhesion
b0136	316407.21238992	9.9e-106	389.4	Escherichia	yadK	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0042995,GO:0043708,GO:0043709,GO:0044010,GO:0044464,GO:0044764,GO:0051704,GO:0090605,GO:0090609											Escherichia	1NZBZ@1224,1SQYM@1236,3XR5S@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
b0137	316407.21238993	4.8e-100	370.5	Escherichia	yadL												Escherichia	1RJYB@1224,1S7ET@1236,3XR7D@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
b0138	316407.21238994	1.1e-98	365.9	Escherichia	yadM	GO:0007155,GO:0008150,GO:0022610											Escherichia	1N055@1224,1SBJ2@1236,3XR2W@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
b0139	316407.85674349	0.0	1730.7	Escherichia	htrE	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944		ko:K07347	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Escherichia	1MUHE@1224,1RMPU@1236,3XQED@561,COG3188@1,COG3188@2	NA|NA|NA	M	outer membrane usher protein
b0140	316407.21238995	4.2e-138	497.3	Escherichia	yadV	GO:0007155,GO:0008150,GO:0009987,GO:0016043,GO:0022610,GO:0030030,GO:0043711,GO:0071840		ko:K15540					ko00000				Escherichia	1MY06@1224,1RR9H@1236,3XRFS@561,COG3121@1,COG3121@2	NA|NA|NA	M	Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
b0141	316407.85674350	3.4e-95	354.4	Escherichia	yadN	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0022610,GO:0042995,GO:0044464											Escherichia	1RGR4@1224,1S3WW@1236,3XR3J@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
b0142	316407.21238998	4.8e-87	327.0	Escherichia	folK	GO:0000287,GO:0003674,GO:0003824,GO:0003848,GO:0005488,GO:0016740,GO:0016772,GO:0016778,GO:0043167,GO:0043169,GO:0046872	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iECDH1ME8569_1439.ECDH1ME8569_0136,iEcDH1_1363.EcDH1_3460,iSBO_1134.SBO_0131	Escherichia	1MZH8@1224,1S63J@1236,3XMN2@561,COG0801@1,COG0801@2	NA|NA|NA	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
b0143	199310.c0176	6.2e-268	929.5	Escherichia	pcnB	GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004652,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006276,GO:0006378,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0031124,GO:0034641,GO:0043170,GO:0043412,GO:0043631,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.7.7.19	ko:K00970	ko03018,map03018				ko00000,ko00001,ko01000,ko03019				Escherichia	1MVCS@1224,1RMBG@1236,3XNZM@561,COG0617@1,COG0617@2	NA|NA|NA	F	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control
b0144	316407.85674352	1e-181	642.5	Escherichia	gluQ	GO:0000166,GO:0002097,GO:0003674,GO:0005488,GO:0005524,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363		ko:K01894					ko00000,ko01000,ko01007,ko03016				Escherichia	1MUN7@1224,1RMYQ@1236,3XN6X@561,COG0008@1,COG0008@2	NA|NA|NA	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon
b0145	1073999.BN137_3015	2.1e-79	301.6	Gammaproteobacteria													Escherichia	1RD08@1224,1S47H@1236,COG1734@1,COG1734@2	NA|NA|NA	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression
b0146	155864.EDL933_0150	7.5e-129	466.5	Escherichia	sfsA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K06206					ko00000				Escherichia	1MUC3@1224,1RQ95@1236,3XMFH@561,COG1489@1,COG1489@2	NA|NA|NA	K	Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism
b0147	316407.85674353	3e-98	364.4	Escherichia	ligT	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0008452,GO:0008664,GO:0016787,GO:0016788,GO:0016874,GO:0016886,GO:0042578,GO:0140098	3.1.4.58	ko:K01975					ko00000,ko01000,ko03016				Escherichia	1RDB2@1224,1SCZX@1236,3XMSE@561,COG1514@1,COG1514@2	NA|NA|NA	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
b0148	316407.85674354	0.0	1573.9	Escherichia	hrpB		3.6.4.13	ko:K03579					ko00000,ko01000				Escherichia	1MUEQ@1224,1RR1B@1236,3XN52@561,COG1643@1,COG1643@2	NA|NA|NA	L	ATP-dependent helicase activity
b0149	316407.85674355	0.0	1514.6	Escherichia	mrcB	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550		R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011		GT51	iECIAI39_1322.ECIAI39_0153,iSBO_1134.SBO_0138,iSbBS512_1146.SbBS512_E0140	Escherichia	1QTST@1224,1RNHV@1236,3XM7W@561,COG0744@1,COG0744@2	NA|NA|NA	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
b0150	316407.85674356	0.0	1504.2	Escherichia	fhuA	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005623,GO:0009279,GO:0015643,GO:0016020,GO:0019867,GO:0019904,GO:0030312,GO:0030313,GO:0031975,GO:0043167,GO:0043169,GO:0044462,GO:0044464,GO:0046790,GO:0046872,GO:0046914,GO:0048037,GO:0071944		ko:K02014					ko00000,ko02000	1.B.14		iECSE_1348.ECSE_0151,iECW_1372.ECW_m0147,iEKO11_1354.EKO11_3766,iEcolC_1368.EcolC_3509,iWFL_1372.ECW_m0147	Escherichia	1MV0X@1224,1T1GW@1236,3XM9E@561,COG4774@1,COG4774@2	NA|NA|NA	P	Involved in the uptake of iron in complex with ferrichrome, an hydroxamate-type siderophore. Binds and transports ferrichrome-iron across the outer membrane. In addition to its role in ferrichrome-iron transport, transports the antibiotic albomycin, which is a structural analog of ferrichrome, and acts as a receptor for colicin M, microcin J25 and bacteriophages T1, T5, phi80 and UC-1. The energy source, which is required for all FhuA functions except infection by phage T5, is provided by the inner membrane TonB system
b0151	316407.85674357	7.4e-149	533.1	Escherichia	fhuC	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.34	ko:K02013	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14		iECNA114_1301.ECNA114_0142,iECSF_1327.ECSF_0168	Escherichia	1MUNG@1224,1RQ6C@1236,3XNM1@561,COG1120@1,COG1120@2	NA|NA|NA	P	Part of the ABC transporter complex FhuCDB involved in iron(3 )-hydroxamate import. Responsible for energy coupling to the transport system
b0152	316407.85674358	8.5e-170	602.8	Escherichia	fhuD	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K02016	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14		iAPECO1_1312.APECO1_1833,iEC042_1314.EC042_0152,iECABU_c1320.ECABU_c01660,iECNA114_1301.ECNA114_0143,iECOK1_1307.ECOK1_0155,iECS88_1305.ECS88_0163,iECSF_1327.ECSF_0169,iLF82_1304.LF82_0653,iNRG857_1313.NRG857_00790,iSDY_1059.SDY_0168,iUMN146_1321.UM146_23575	Escherichia	1PEJ1@1224,1RNIS@1236,3XN97@561,COG0614@1,COG0614@2	NA|NA|NA	P	Part of the ABC transporter complex FhuCDB involved in iron(3 )-hydroxamate import. Binds the iron(3 )-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3 )-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin
b0153	316407.85674359	0.0	1234.9	Escherichia	fhuB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K02015	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14		iECP_1309.ECP_0163	Escherichia	1MVA3@1224,1RN0J@1236,3XMUG@561,COG0609@1,COG0609@2	NA|NA|NA	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
b0154	316407.85674360	6.5e-248	862.8	Escherichia	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007			iUMNK88_1353.UMNK88_158	Escherichia	1MUY5@1224,1RM7N@1236,3XNJF@561,COG0001@1,COG0001@2	NA|NA|NA	H	glutamate-1-semialdehyde 2,1-aminomutase activity
b0155	316407.85674361	2.4e-259	901.0	Escherichia	clcA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006821,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015672,GO:0015698,GO:0015706,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0031404,GO:0034220,GO:0042802,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K03281					ko00000	2.A.49		iAF1260.b0155,iB21_1397.B21_00153,iBWG_1329.BWG_0148,iE2348C_1286.E2348C_0162,iEC042_1314.EC042_0155,iEC55989_1330.EC55989_0149,iECBD_1354.ECBD_3463,iECDH10B_1368.ECDH10B_0135,iECDH1ME8569_1439.ECDH1ME8569_0149,iECD_1391.ECD_00154,iECIAI1_1343.ECIAI1_0153,iECO103_1326.ECO103_0155,iECSE_1348.ECSE_0156,iECUMN_1333.ECUMN_0152,iECW_1372.ECW_m0152,iEKO11_1354.EKO11_3761,iETEC_1333.ETEC_0151,iEcDH1_1363.EcDH1_3447,iEcE24377_1341.EcE24377A_0160,iEcolC_1368.EcolC_3504,iJO1366.b0155,iSSON_1240.SSON_0167,iUMNK88_1353.UMNK88_159,iWFL_1372.ECW_m0152,iY75_1357.Y75_RS00790,iZ_1308.Z0166	Escherichia	1MV4K@1224,1RQJW@1236,3XPHI@561,COG0038@1,COG0038@2	NA|NA|NA	P	proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response
b0156	155864.EDL933_0161	2.3e-59	234.6	Escherichia	erpA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:1901564		ko:K15724					ko00000				Escherichia	1RHCW@1224,1S675@1236,3XPP3@561,COG0316@1,COG0316@2	NA|NA|NA	C	Probably involved in the insertion of Fe-S clusters into apoproteins in vivo including IspG and or IspH. Essential for growth under aerobic conditions and for anaerobic respiration but not for fermentation. In vitro it binds Fe-S clusters and transfers them to apo-IspG, which is involved in quinone biosynthesis among many other cell components. Experiments indicate that it is probably also involved in the insertion of other Fe-S clusters than IspG IspH
b0157	199310.c0193	5.8e-109	400.2	Escherichia	yadS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RHQN@1224,1S5YY@1236,3XNQY@561,COG2860@1,COG2860@2	NA|NA|NA	S	UPF0126 domain
b0158	316407.85674362	8.2e-148	529.6	Escherichia	btuF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008144,GO:0008150,GO:0015889,GO:0015893,GO:0019842,GO:0030288,GO:0030313,GO:0031419,GO:0031975,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0097159,GO:1901363		ko:K06858	ko02010,map02010	M00241			ko00000,ko00001,ko00002,ko02000	3.A.1.13		iECH74115_1262.ECH74115_0168,iECSP_1301.ECSP_0159,iECs_1301.ECs0162,iZ_1308.Z0169	Escherichia	1MWVF@1224,1RMV8@1236,3XNJV@561,COG0614@1,COG0614@2	NA|NA|NA	P	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC
b0159	155864.EDL933_0164	1.9e-124	451.8	Escherichia	mtnN	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008652,GO:0008782,GO:0008930,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009116,GO:0009119,GO:0009987,GO:0016053,GO:0016787,GO:0016798,GO:0016799,GO:0017144,GO:0019284,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0042802,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046394,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000			iSBO_1134.SBO_0148	Escherichia	1MY5S@1224,1RNSF@1236,3XNQB@561,COG0775@1,COG0775@2	NA|NA|NA	F	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
b0160	316407.21239016	3.7e-298	1030.0	Escherichia	dgt	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0015949,GO:0016462,GO:0016787,GO:0016788,GO:0016793,GO:0016817,GO:0016818,GO:0017111,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0050897,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230		R01856	RC00017	ko00000,ko00001,ko01000				Escherichia	1MVQ2@1224,1RPVJ@1236,3XMKE@561,COG0232@1,COG0232@2	NA|NA|NA	F	dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs
b0161	155864.EDL933_0166	1.6e-255	888.3	Escherichia	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728			ko00000,ko00001,ko00002,ko01000,ko01002,ko03110				Escherichia	1MU63@1224,1RN9T@1236,3XMGW@561,COG0265@1,COG0265@2	NA|NA|NA	O	DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. Degrades transiently denatured and unfolded or misfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, Ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP)
b0162	316407.85674363	6e-216	756.5	Escherichia	cdaR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K02647					ko00000,ko03000				Escherichia	1NJZ9@1224,1RMEP@1236,3XNXX@561,COG3835@1,COG3835@2	NA|NA|NA	K	diacid regulator
b0163	1440052.EAKF1_ch1250	9.3e-65	252.7	Escherichia	yaeH												Escherichia	1RD2V@1224,1S3XU@1236,28NXJ@1,2ZBV4@2,3XPIG@561	NA|NA|NA	S	Belongs to the UPF0325 family
b0164	316407.85674364	1.2e-157	562.4	Escherichia	yaeI			ko:K07098					ko00000				Escherichia	1RK37@1224,1SEEW@1236,3XP7Z@561,COG1408@1,COG1408@2	NA|NA|NA	S	Shows phosphodiesterase activity, hydrolyzing phosphodiester bond in the artificial chromogenic substrate bis-p- nitrophenyl phosphate (bis-pNPP)
b0166	198214.SF0156	2.1e-122	445.3	Gammaproteobacteria													Escherichia	1MU0Y@1224,1RPCS@1236,COG2171@1,COG2171@2	NA|NA|NA	E	Belongs to the transferase hexapeptide repeat family
b0167	316407.85674365	0.0	1799.3	Escherichia	glnD	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008773,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070569,GO:0071704,GO:0140096,GO:1901564	2.7.7.59	ko:K00990	ko02020,map02020				ko00000,ko00001,ko01000				Escherichia	1MV54@1224,1RN5T@1236,3XMIM@561,COG2844@1,COG2844@2	NA|NA|NA	O	in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
b0168	155864.EDL933_0171	6e-151	540.0	Escherichia	map	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564	3.4.11.18	ko:K01265					ko00000,ko01000,ko01002				Escherichia	1MU99@1224,1RMHN@1236,3XMB7@561,COG0024@1,COG0024@2	NA|NA|NA	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed
b0169	1440052.EAKF1_ch1245c	1.5e-132	478.8	Escherichia	rpsB	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02967	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1MU33@1224,1RN0Z@1236,3XMCP@561,COG0052@1,COG0052@2	NA|NA|NA	J	ribosomal protein
b0170	1440052.EAKF1_ch1244c	1.8e-148	531.9	Escherichia	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02357					ko00000,ko03012,ko03029				Escherichia	1MUS2@1224,1RPBJ@1236,3XNI1@561,COG0264@1,COG0264@2	NA|NA|NA	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
b0171	155864.EDL933_0175	1.6e-129	468.8	Escherichia	pyrH	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0033862,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100		R00158	RC00002	ko00000,ko00001,ko01000				Escherichia	1MV3N@1224,1RMHX@1236,3XP3X@561,COG0528@1,COG0528@2	NA|NA|NA	F	Catalyzes the reversible phosphorylation of UMP to UDP
b0172	155864.EDL933_0176	9.9e-76	289.7	Escherichia	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576		ko:K02838					ko00000,ko03012				Escherichia	1N66T@1224,1RN75@1236,3XNVW@561,COG0233@1,COG0233@2	NA|NA|NA	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
b0173	316407.85674366	1.2e-222	778.9	Escherichia	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188	Escherichia	1MU4G@1224,1RNNW@1236,3XNDF@561,COG0743@1,COG0743@2	NA|NA|NA	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
b0174	155864.EDL933_0178	2.9e-142	511.1	Escherichia	uppS	GO:0000270,GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006066,GO:0006629,GO:0006720,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110		R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006			iECBD_1354.ECBD_3445,iECOK1_1307.ECOK1_0175,iECSE_1348.ECSE_0173,iECW_1372.ECW_m0170,iEKO11_1354.EKO11_3744,iEcDH1_1363.EcDH1_3429,iEcE24377_1341.EcE24377A_0178,iEcHS_1320.EcHS_A0176,iNRG857_1313.NRG857_00890,iSFV_1184.SFV_0157,iUMN146_1321.UM146_23675,iUMNK88_1353.UMNK88_178,iWFL_1372.ECW_m0170,iY75_1357.Y75_RS00880	Escherichia	1MVP1@1224,1RMVX@1236,3XP81@561,COG0020@1,COG0020@2	NA|NA|NA	I	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide
b0175	316407.85674368	1.6e-157	562.0	Escherichia	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_0191	Escherichia	1MWSV@1224,1RQ6M@1236,3XP45@561,COG0575@1,COG0575@2	NA|NA|NA	I	Belongs to the CDS family
b0176	155864.EDL933_0181	1.8e-256	891.3	Escherichia	rseP	GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K11749	ko02024,ko04112,map02024,map04112				ko00000,ko00001,ko01000,ko01002				Escherichia	1MU91@1224,1RMIX@1236,3XNTH@561,COG0750@1,COG0750@2	NA|NA|NA	M	A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA
b0177	155864.EDL933_0182	0.0	1654.0	Escherichia	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063		ko:K07277					ko00000,ko02000,ko03029	1.B.33			Escherichia	1MU0D@1224,1RMAP@1236,3XNR5@561,COG4775@1,COG4775@2	NA|NA|NA	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery
b0178	155864.EDL933_0183	2.1e-74	285.0	Escherichia	skp	GO:0001530,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022417,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0032978,GO:0033036,GO:0034613,GO:0042597,GO:0042802,GO:0043163,GO:0043165,GO:0043170,GO:0044085,GO:0044091,GO:0044238,GO:0044464,GO:0045184,GO:0045229,GO:0050821,GO:0051082,GO:0051179,GO:0051205,GO:0051234,GO:0051604,GO:0051641,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0070727,GO:0071704,GO:0071709,GO:0071840,GO:0072657,GO:0090150,GO:0097367,GO:1901564		ko:K06142					ko00000				Escherichia	1RD8X@1224,1RQIE@1236,3XMTR@561,COG2825@1,COG2825@2	NA|NA|NA	M	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm
b0179	316407.4902920	1.5e-122	446.0	Escherichia	lpxD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005			ic_1306.c0216	Escherichia	1MUX6@1224,1RNYI@1236,3XP03@561,COG1044@1,COG1044@2	NA|NA|NA	M	Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
b0180	199310.c0217	1.4e-80	305.4	Escherichia	fabZ	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004				Escherichia	1RH2T@1224,1S63E@1236,3XMPU@561,COG0764@1,COG0764@2	NA|NA|NA	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
b0181	155864.EDL933_0186	5.9e-90	337.4	Escherichia	lpxA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008374,GO:0008780,GO:0016740,GO:0016746,GO:0016747,GO:0042802,GO:0044424,GO:0044444,GO:0044464	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005				Escherichia	1MUHQ@1224,1RPHB@1236,3XP5H@561,COG1043@1,COG1043@2	NA|NA|NA	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
b0182	316407.85674371	8.3e-218	762.7	Escherichia	lpxB	GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT19	iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478	Escherichia	1MVBI@1224,1RNS1@1236,3XNR7@561,COG0763@1,COG0763@2	NA|NA|NA	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
b0183	316407.85674372	5.8e-106	390.2	Escherichia	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Escherichia	1RA65@1224,1RQ4B@1236,3XMIB@561,COG0164@1,COG0164@2	NA|NA|NA	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
b0184	316407.4902925	0.0	2331.6	Escherichia	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Escherichia	1MUIF@1224,1RP0K@1236,3XMAZ@561,COG0587@1,COG0587@2	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase
b0185	155864.EDL933_0190	4.5e-177	627.1	Escherichia	accA	GO:0001676,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000			iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197	Escherichia	1MURN@1224,1RNN8@1236,3XMGT@561,COG0825@1,COG0825@2	NA|NA|NA	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
b0186	316407.85674374	0.0	1473.4	Escherichia	ldcC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006553,GO:0006554,GO:0006807,GO:0008150,GO:0008152,GO:0008923,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.1.1.18	ko:K01582	ko00310,ko00960,ko01100,ko01110,map00310,map00960,map01100,map01110		R00462	RC00299	ko00000,ko00001,ko01000			iSbBS512_1146.SbBS512_E0179	Escherichia	1MWK4@1224,1RMVF@1236,3XP4E@561,COG1982@1,COG1982@2	NA|NA|NA	E	lysine decarboxylase
b0187	316407.4902928	3.9e-71	273.9	Escherichia	yaeR			ko:K08234					ko00000				Escherichia	1RGZ8@1224,1S66M@1236,3XPM4@561,COG0346@1,COG0346@2	NA|NA|NA	E	metal ion binding
b0188	316407.4902929	5.4e-250	869.8	Escherichia	tilS	GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	6.3.4.19	ko:K04075			R09597	RC02633,RC02634	ko00000,ko01000,ko03016				Escherichia	1MU85@1224,1RN14@1236,3XP50@561,COG0037@1,COG0037@2	NA|NA|NA	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
b0189	155864.EDL933_0194	8.9e-40	169.1	Escherichia	rof	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K19000					ko00000,ko03021				Escherichia	1MZYG@1224,1S8Y7@1236,3XPVJ@561,COG4568@1,COG4568@2	NA|NA|NA	K	transcription antitermination
b4406	198214.SF0180	1.2e-28	131.7	Gammaproteobacteria													Escherichia	1N70N@1224,1SD0N@1236,2E480@1,32Z3X@2	NA|NA|NA	S	Belongs to the UPF0253 family
b0190	198214.SF0181	1.5e-100	372.1	Gammaproteobacteria													Escherichia	1RDR9@1224,1S43N@1236,COG4681@1,COG4681@2	NA|NA|NA	S	protein conserved in bacteria
b0191	316407.85674377	1.1e-53	216.1	Escherichia	yaeJ	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112		ko:K15034					ko00000,ko03012				Escherichia	1RH75@1224,1S5YQ@1236,3XPJ1@561,COG1186@1,COG1186@2	NA|NA|NA	J	Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters or ribosomes stalled in the middle of mRNA. First identified as a complementary ribosome rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)-SmpB quality control system or the alternative ribosome-rescue factor A (arfA)
b0192	316407.4902934	3e-133	481.1	Escherichia	cutF	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0010810,GO:0016020,GO:0019867,GO:0030155,GO:0030312,GO:0030313,GO:0031975,GO:0042802,GO:0044462,GO:0044464,GO:0050789,GO:0065007,GO:0071944		ko:K06079	ko01503,map01503				ko00000,ko00001				Escherichia	1NZ8R@1224,1S0ZA@1236,3XNQV@561,COG3015@1,COG3015@2	NA|NA|NA	M	Copper homeostasis protein
b0193	316407.85674378	3.5e-154	550.8	Escherichia	yaeF												Escherichia	1RA8M@1224,1S2BB@1236,3XQMF@561,COG0791@1,COG0791@2	NA|NA|NA	M	cysteine-type peptidase activity
b0194	316407.85674379	0.0	1125.5	Escherichia	proS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iUTI89_1310.UTI89_C0210	Escherichia	1MU7E@1224,1RN5R@1236,3XMX1@561,COG0442@1,COG0442@2	NA|NA|NA	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro)
b0195	316407.4902937	3.3e-132	477.6	Escherichia	yaeB	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0089715,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363											Escherichia	1MUF0@1224,1RPCX@1236,3XM3F@561,COG1720@1,COG1720@2	NA|NA|NA	S	S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Thr)(GGU) that read codons starting with adenosine. The methyl group of m(6)t(6)A37 appears to slightly improve the efficiency of the tRNA decoding ability. Binds to tRNA
b0196	199310.c0237	2.1e-67	261.5	Escherichia	rcsF	GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009279,GO:0009987,GO:0016020,GO:0016051,GO:0019867,GO:0023052,GO:0030312,GO:0030313,GO:0031240,GO:0031241,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044462,GO:0044464,GO:0046377,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0098552,GO:1901135,GO:1901137,GO:1901576		ko:K06080	ko02020,map02020				ko00000,ko00001				Escherichia	1RIKW@1224,1S6DZ@1236,2B4JI@1,31XBN@2,3XPIX@561	NA|NA|NA	M	Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects
b0197	316407.4902940	1.7e-148	531.9	Escherichia	metQ	GO:0000101,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015821,GO:0015849,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031225,GO:0031226,GO:0031975,GO:0032991,GO:0042597,GO:0042940,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0046658,GO:0046942,GO:0048473,GO:0051179,GO:0051234,GO:0055052,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K02073	ko02010,map02010	M00238			ko00000,ko00001,ko00002,ko02000	3.A.1.24		ic_1306.c0238	Escherichia	1MUVY@1224,1RS3R@1236,3XN1X@561,COG1464@1,COG1464@2	NA|NA|NA	P	Belongs to the NlpA lipoprotein family
b0198	316407.4902941	4e-76	291.2	Escherichia	metI	GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015191,GO:0015238,GO:0015318,GO:0015711,GO:0015807,GO:0015821,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0043190,GO:0043865,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0048473,GO:0050896,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098533,GO:0098655,GO:0098656,GO:0098796,GO:0098797,GO:1901682,GO:1902475,GO:1902494,GO:1902495,GO:1903825,GO:1904949,GO:1905039,GO:1990351		ko:K02072	ko02010,map02010	M00238			ko00000,ko00001,ko00002,ko02000	3.A.1.24			Escherichia	1MW8E@1224,1RPKY@1236,3XN58@561,COG2011@1,COG2011@2	NA|NA|NA	P	Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl- methionine. Probably responsible for the translocation of the substrate across the membrane
b0199	316407.85674381	1.7e-190	671.8	Escherichia	metN	GO:0000099,GO:0000101,GO:0000166,GO:0003333,GO:0003674,GO:0003824,GO:0005215,GO:0005342,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008144,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015191,GO:0015238,GO:0015318,GO:0015399,GO:0015405,GO:0015711,GO:0015807,GO:0015821,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034220,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042940,GO:0042943,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0043865,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0048473,GO:0048474,GO:0050896,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0097159,GO:0097367,GO:0098533,GO:0098655,GO:0098656,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1901682,GO:1902475,GO:1902494,GO:1902495,GO:1903825,GO:1904949,GO:1905039,GO:1990351		ko:K02071	ko02010,map02010	M00238			ko00000,ko00001,ko00002,ko02000	3.A.1.24		iAF1260.b0199,iBWG_1329.BWG_0192,iECDH10B_1368.ECDH10B_0180,iECDH1ME8569_1439.ECDH1ME8569_0193,iECP_1309.ECP_0209,iEcDH1_1363.EcDH1_3403,iEcSMS35_1347.EcSMS35_0211,iJO1366.b0199,iJR904.b0199,iUMNK88_1353.UMNK88_205,iY75_1357.Y75_RS01010	Escherichia	1QTTK@1224,1RMQD@1236,3XN54@561,COG1135@1,COG1135@2	NA|NA|NA	P	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
b0200	155864.EDL933_0206	1.1e-106	392.5	Escherichia	gmhB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033692,GO:0034200,GO:0034637,GO:0034645,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046872,GO:0046914,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005			iB21_1397.B21_00198,iEC55989_1330.EC55989_0198,iECBD_1354.ECBD_3418,iECB_1328.ECB_00199,iECD_1391.ECD_00199,iECIAI1_1343.ECIAI1_0202,iECO103_1326.ECO103_0200,iECSE_1348.ECSE_0202,iETEC_1333.ETEC_0196,iEcHS_1320.EcHS_A0204,iEcolC_1368.EcolC_3459	Escherichia	1RDGR@1224,1S3UD@1236,3XN2T@561,COG0241@1,COG0241@2	NA|NA|NA	F	by removing the phosphate group at the C-7 position
b0207	316407.85674382	3.5e-146	524.2	Escherichia	dkgB	GO:0003674,GO:0003824,GO:0004033,GO:0006081,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0047681,GO:0051596,GO:0055114,GO:0071704,GO:1901575,GO:1990002	1.1.1.346	ko:K06222					ko00000,ko01000			iEcolC_1368.EcolC_3458	Escherichia	1MWFS@1224,1RMX6@1236,3XPB8@561,COG0656@1,COG0656@2	NA|NA|NA	S	Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG)
b0208	316407.4902945	1.2e-163	582.4	Escherichia	yafC	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1MU7H@1224,1RPF8@1236,3XM7Z@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
b0209	199310.c0246	1.1e-149	535.8	Escherichia	yafD												Escherichia	1MVPP@1224,1RMBH@1236,3XNMK@561,COG3021@1,COG3021@2	NA|NA|NA	S	UPF0294 protein YafD
b0210	316407.4902947	1.8e-113	415.2	Escherichia	yafE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464											Escherichia	1PN45@1224,1RP4K@1236,3XNY0@561,COG0500@1,COG2226@2	NA|NA|NA	Q	S-adenosylmethionine-dependent methyltransferase activity
b0211	199310.c0248	2.9e-254	884.0	Escherichia	mltD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009		ko:K08307					ko00000,ko01000,ko01011				Escherichia	1MWKE@1224,1RMFZ@1236,3XMF8@561,COG0741@1,COG0741@2,COG1388@1,COG1388@2	NA|NA|NA	M	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division (By similarity)
b0212	155864.EDL933_0212	7.2e-146	523.1	Escherichia	gloB	GO:0003674,GO:0003824,GO:0004416,GO:0005488,GO:0006081,GO:0006082,GO:0006089,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009266,GO:0009408,GO:0009438,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046872,GO:0046914,GO:0050896,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615	3.1.2.6	ko:K01069	ko00620,map00620		R01736	RC00004,RC00137	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c02250	Escherichia	1MU8Q@1224,1S22I@1236,3XMRR@561,COG0491@1,COG0491@2	NA|NA|NA	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
b0213	316407.4902950	1.1e-140	505.8	Escherichia	yafS												Escherichia	1QTWC@1224,1RS4G@1236,3XMFC@561,COG0500@1,COG2226@2	NA|NA|NA	Q	methyltransferase activity
b0214	155864.EDL933_0214	3.3e-88	330.9	Escherichia	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901576	3.1.26.4	ko:K03469	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Escherichia	1RCZ1@1224,1S3YC@1236,3XNJ9@561,COG0328@1,COG0328@2	NA|NA|NA	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
b0215	316407.4902952	4.7e-134	483.8	Escherichia	dnaQ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Escherichia	1MV8Z@1224,1RNHQ@1236,3XMNA@561,COG0847@1,COG0847@2	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
b0217	316407.4902953	5.2e-139	500.4	Escherichia	yafT												Escherichia	1MWA4@1224,1S0IC@1236,28N94@1,2ZBD8@2,3XQDQ@561	NA|NA|NA		
b4586	511145.b4586	4.4e-64	250.8	Escherichia		GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0042221,GO:0046677,GO:0050896,GO:0051716											Escherichia	1QIHE@1224,1TGC1@1236,2AVGC@1,31M8I@2,3XQG3@561	NA|NA|NA		
b0218	316407.85674385	2.2e-54	218.0	Gammaproteobacteria													Escherichia	1R717@1224,1RYDC@1236,COG4104@1,COG4104@2	NA|NA|NA	S	PAAR repeat-containing protein
b4503	316407.4902954	5.4e-26	122.9	Bacteria													Escherichia	COG5433@1,COG5433@2	NA|NA|NA	L	transposase activity
b0219	316407.85674386	5.5e-149	533.5	Escherichia	yafV	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050152,GO:0071944,GO:0106008	3.5.1.3	ko:K13566	ko00250,map00250		R00269,R00348	RC00010	ko00000,ko00001,ko01000				Escherichia	1MXBR@1224,1RQ4Z@1236,3XME3@561,COG0388@1,COG0388@2	NA|NA|NA	S	Hydrolyzes alpha-ketoglutaramate (a-KGM) to alpha- ketoglutarate (alpha-KG) and ammonia, has weak activity on L- glutamine, almost no activity on deaminated glutathione (dGSH) and none on glutathione (By similarity). May function as a metabolite repair enzyme (By similarity)
b0220	316407.4902956	1.2e-82	312.4	Escherichia	ivy	GO:0003674,GO:0004857,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0030234,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043086,GO:0044092,GO:0044464,GO:0050790,GO:0060241,GO:0061077,GO:0065007,GO:0065009,GO:0098772											Escherichia	1QJ60@1224,1RPEI@1236,29IKC@1,305HJ@2,3XNE1@561	NA|NA|NA	O	Inhibitor of vertebrate lysozyme
b0221	316407.85674387	0.0	1627.5	Escherichia	fadE	GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575		ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000			iSbBS512_1146.SbBS512_E0217	Escherichia	1MUDR@1224,1RPM5@1236,3XNAM@561,COG1960@1,COG1960@2	NA|NA|NA	I	Catalyzes the dehydrogenation of acyl-coenzymes A (acyl- CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for
b0222	1440052.EAKF1_ch1194c	1.3e-102	379.0	Escherichia	gmhA	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008968,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016853,GO:0016866,GO:0016868,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005				Escherichia	1NVIE@1224,1RP6M@1236,3XND9@561,COG0279@1,COG0279@2	NA|NA|NA	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate
b0223	316407.4902959	2.8e-153	547.7	Escherichia	yafJ												Escherichia	1MU1J@1224,1RNEK@1236,3XM9M@561,COG0121@1,COG0121@2	NA|NA|NA	S	glutamine metabolic process
b0224	155864.EDL933_0254	1.3e-139	502.3	Escherichia	yafK												Escherichia	1MXY6@1224,1RPXT@1236,3XP6E@561,COG3034@1,COG3034@2	NA|NA|NA	M	peptidoglycan biosynthetic process
b0225	316407.4902961	9.7e-48	195.7	Gammaproteobacteria													Escherichia	1N9NX@1224,1SCBQ@1236,COG3041@1,COG3041@2	NA|NA|NA	S	Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific mRNA endoribonuclease that inhibits translation elongation and induces bacterial stasis. Cleavage occurs between the second and third residue of the Lys codon followed by a G or A (5'AAA(G A)3'), is reading-frame dependent and occurs within the 5' end of most mRNAs. Ribosome-binding confers the sequence specificity and reading frame-dependence. When overexpressed in liquid media YafQ partially inhibits protein synthesis, with a reduction in growth rate and colony growth rate. This effect is counteracted by coexpression with cognate antitoxin DinJ. YafQ and DinJ together bind their own promoter, and repress its expression
b0226	316407.4902962	4.5e-39	166.8	Gammaproteobacteria													Escherichia	1NA1R@1224,1SBX3@1236,COG3077@1,COG3077@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. A labile antitoxin that counteracts the effect of cognate toxin YafQ. YafQ and DinJ together bind their own promoter, and repress its expression. There are 2 operators with imperfect inverted repeats (IR) in the dinJ promoter, YafQ-(DinJ)2-YafQ only binds to the first (most upstream) of them to repress transcription
b0227	316407.85674388	5.3e-141	506.9	Escherichia	yafL												Escherichia	1N0EE@1224,1RP3P@1236,3XP3U@561,COG0791@1,COG0791@2	NA|NA|NA	M	cysteine-type peptidase activity
b0228	316407.4902964	1.5e-99	368.6	Escherichia	yafM	GO:0000014,GO:0000217,GO:0000405,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0032448,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363		ko:K07491					ko00000				Escherichia	1RCWW@1224,1S3ZJ@1236,3XPI8@561,COG1943@1,COG1943@2	NA|NA|NA	L	Transposase that is always flanked by repeated extragenic palindrome (REP) sequences, which are clustered in structures called bacterial interspersed mosaic elements (BIMEs). RayT catalyzes cleavage and recombination of BIMEs. Binds REP sequences and cleaves BIMEs both upstream and downstream of the REP sequence. Could be important in the creation of BIME variability and amplification
b0229	754331.AEME01000001_gene4051	5.2e-309	1066.2	Escherichia	fhiA			ko:K02400	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Escherichia	1MUF3@1224,1RMSM@1236,3XM97@561,COG1298@1,COG1298@2	NA|NA|NA	NU	FHIPEP family
b0230	155864.EDL933_0263	3.2e-133	481.1	Escherichia	mbhA			ko:K02557	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1			Escherichia	1MW1Y@1224,1RPQ9@1236,3XN14@561,COG1360@1,COG1360@2	NA|NA|NA	N	OmpA family
b0231	316407.4902967	3.2e-200	704.1	Escherichia	dinB	GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031668,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02346					ko00000,ko01000,ko03400				Escherichia	1MUUH@1224,1RMFM@1236,3XNHP@561,COG0389@1,COG0389@2	NA|NA|NA	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
b0232	316407.85674389	7.3e-46	189.5	Gammaproteobacteria													Escherichia	1RK8K@1224,1S85R@1236,COG2161@1,COG2161@2	NA|NA|NA	D	Antitoxin component of a toxin-antitoxin (TA) module
b0233	316407.4902968	6.2e-72	276.6	Gammaproteobacteria													Escherichia	1RAMY@1224,1S2NG@1236,28S4M@1,2ZEGB@2	NA|NA|NA	S	this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome
b0234	316407.4902969	9.8e-82	309.3	Escherichia	yafP			ko:K03830					ko00000,ko01000				Escherichia	1QUD7@1224,1T1U8@1236,3XQ3D@561,COG0454@1,COG0454@2	NA|NA|NA	K	SOS response
b0235	316407.85674390	1.9e-45	188.0	Gammaproteobacteria													Escherichia	1MUHA@1224,1RN50@1236,COG1690@1,COG1690@2	NA|NA|NA	S	release factor H-coupled RctB family protein
b0236	199310.c0382	2e-83	315.1	Escherichia	prfH			ko:K02839					ko00000,ko03012				Escherichia	1R9YA@1224,1RR3F@1236,3XQBB@561,COG1186@1,COG1186@2	NA|NA|NA	J	RF-1 domain
b0237	316407.4902972	2.1e-282	977.6	Escherichia	pepD	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575		ko:K01270	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002			iSBO_1134.SBO_0243	Escherichia	1MUWK@1224,1RP5F@1236,3XN1M@561,COG2195@1,COG2195@2	NA|NA|NA	E	Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity, which is sufficient for E.coli to utilize cysteinylglycine as a cysteine source
b0238	155864.EDL933_0271	6.2e-84	316.6	Escherichia	gpt	GO:0000310,GO:0003674,GO:0003824,GO:0004422,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0032265,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.22	ko:K00769	ko00230,ko01100,ko01110,map00230,map01100,map01110		R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000			iSbBS512_1146.SbBS512_E0235	Escherichia	1MWNE@1224,1RQ4C@1236,3XMFY@561,COG2236@1,COG2236@2	NA|NA|NA	F	Acts on guanine, xanthine and to a lesser extent hypoxanthine
b0239	316407.85674392	8e-251	872.5	Escherichia	frsA	GO:0003674,GO:0003824,GO:0006109,GO:0008150,GO:0009894,GO:0016787,GO:0019222,GO:0043470,GO:0050789,GO:0065007,GO:0080090		ko:K11750					ko00000,ko01000				Escherichia	1N5CG@1224,1RR2Y@1236,3XM8M@561,COG1073@1,COG1073@2	NA|NA|NA	S	Displays esterase activity toward pNP-butyrate
b4710	177439.DP0860	5.6e-94	350.1	Proteobacteria													Escherichia	1NHAK@1224,COG1662@1,COG1662@2	NA|NA|NA	L	cog cog1662
b4709	1035839.AFNK01000018_gene1622	9e-46	189.1	Gammaproteobacteria													Escherichia	1NP8S@1224,1SDQB@1236,COG3677@1,COG3677@2	NA|NA|NA	L	PFAM Insertion element protein
b0241	316407.4902976	3.8e-201	707.2	Escherichia	phoE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009279,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0019219,GO:0019222,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031975,GO:0032991,GO:0044424,GO:0044425,GO:0044444,GO:0044462,GO:0044464,GO:0045893,GO:0045935,GO:0046930,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0098796,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K11929					ko00000,ko02000	1.B.1.1.2		iECO26_1355.ECO26_0297	Escherichia	1MVRY@1224,1RNBS@1236,3XPDV@561,COG3203@1,COG3203@2	NA|NA|NA	M	Belongs to the Gram-negative porin family
b0242	155864.EDL933_0275	2.7e-202	711.1	Escherichia	proB	GO:0000287,GO:0003674,GO:0003824,GO:0004349,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019202,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0055129,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901973	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000				Escherichia	1MUBG@1224,1RM7X@1236,3XM4J@561,COG0263@1,COG0263@2	NA|NA|NA	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
b0243	316407.85674395	1.6e-227	795.0	Escherichia	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240	Escherichia	1MUGJ@1224,1RMAY@1236,3XN41@561,COG0014@1,COG0014@2	NA|NA|NA	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
b0245	316407.85674396	2.8e-57	227.6	Escherichia	ykfI	GO:0001558,GO:0008150,GO:0030308,GO:0040008,GO:0045926,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0065007		ko:K18837					ko00000,ko02048				Escherichia	1RG1Q@1224,1S4SC@1236,2C4I5@1,30CTH@2,3XR4I@561	NA|NA|NA	S	Toxic component of a toxin-antitoxin (TA) system. Overexpression results in inhibition of growth in liquid cultures and a decrease in colony formation
b0246	316407.4902980	8.5e-56	222.6	Gammaproteobacteria													Escherichia	1N5CU@1224,1SAAM@1236,2BMAS@1,32T1E@2	NA|NA|NA	S	regulation of cytoskeleton organization
b4504	316407.4902981	2.7e-37	160.6	Escherichia	ykfH												Escherichia	1N2MQ@1224,1S8RA@1236,2CZYD@1,32T7D@2,3XR6D@561	NA|NA|NA	S	Protein of unknown function (DUF987)
b0247	316407.4902982	5e-84	317.0	Escherichia	ykfG			ko:K03630					ko00000				Escherichia	1MW2D@1224,1S0RG@1236,3XQMM@561,COG2003@1,COG2003@2	NA|NA|NA	E	Belongs to the UPF0758 family
b0248	316407.85674397	4.2e-88	330.5	Escherichia	yafX												Escherichia	1REBZ@1224,1S3SZ@1236,2921C@1,2ZPKK@2,3XQ53@561	NA|NA|NA	S	Escherichia coli O157 H7 ortholog z1656
b0249	316407.85674398	7.1e-39	166.0	Gammaproteobacteria													Escherichia	1NAPS@1224,1SE5M@1236,2DPNE@1,332RS@2	NA|NA|NA	S	Belongs to the UPF0401 family
b0250	316407.4902985	1.3e-84	318.9	Gammaproteobacteria													Escherichia	1RFAT@1224,1S45U@1236,2DKYD@1,30VQ4@2	NA|NA|NA		
b0251	316407.4902986	3.1e-80	304.3	Bacteria													Escherichia	COG2378@1,COG2378@2	NA|NA|NA	K	regulation of single-species biofilm formation
b0252	316407.4902987	3e-153	547.7	Escherichia	yfjQ												Escherichia	1MVTR@1224,1RMPH@1236,28H9R@1,2Z7MD@2,3XNIG@561	NA|NA|NA	S	Escherichia coli O157 H7 ortholog z1655
b0253	316407.85674399	2.7e-160	571.2	Escherichia	ykfA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K06946					ko00000				Escherichia	1NG19@1224,1RPV6@1236,3XPY9@561,COG3596@1,COG3596@2	NA|NA|NA	S	GTP binding
b0254	316407.4902990	4.4e-166	590.5	Gammaproteobacteria													Escherichia	1R6N4@1224,1RS69@1236,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
b4587	316407.4902991	2.3e-38	164.5	Escherichia													Escherichia	1RIJ6@1224,1TAQW@1236,3XR03@561,COG2963@1,COG2963@2	NA|NA|NA	J	Transposase
b0256	316407.85674400	3.7e-218	763.8	Escherichia		GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363											Escherichia	1PP49@1224,1RN7B@1236,3XQB0@561,COG2826@1,COG2826@2	NA|NA|NA	L	Transposase insI for insertion sequence element
b0258	316407.85674402	8.8e-220	769.2	Escherichia			2.7.7.49	ko:K00986					ko00000,ko01000				Escherichia	1MVI1@1224,1RQP7@1236,3XQ3W@561,COG3344@1,COG3344@2	NA|NA|NA	L	Reverse transcriptase (RNA-dependent DNA polymerase)
b0259	316407.1736552	5.6e-194	683.3	Gammaproteobacteria													Escherichia	1MVDK@1224,1RR0T@1236,COG3039@1,COG3039@2	NA|NA|NA	L	COG3039 Transposase and inactivated derivatives IS5 family
b0260	316407.85674404	2.7e-263	914.1	Escherichia	mmuP	GO:0000096,GO:0000097,GO:0000100,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0015806,GO:0016020,GO:0016053,GO:0019752,GO:0022857,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682		ko:K16235					ko00000,ko02000	2.A.3.1.10			Escherichia	1QTSM@1224,1RNI2@1236,3XQRH@561,COG0833@1,COG0833@2	NA|NA|NA	E	Transporter for the intake of S-methylmethionine
b0261	316407.85674405	4.9e-176	623.6	Escherichia	mmuM	GO:0003674,GO:0003824,GO:0005488,GO:0006575,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008270,GO:0008757,GO:0008898,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033477,GO:0033554,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901564	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110		R00650	RC00003,RC00035	ko00000,ko00001,ko01000				Escherichia	1QU2A@1224,1RS8M@1236,3XN81@561,COG2040@1,COG2040@2	NA|NA|NA	E	Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine
b0262	316407.85674406	2.7e-199	701.0	Escherichia	fbpC		3.6.3.30	ko:K02010	ko02010,map02010	M00190			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10			Escherichia	1MU3I@1224,1RMTS@1236,3XQAR@561,COG3842@1,COG3842@2	NA|NA|NA	E	Part of the ABC transporter complex FbpABC involved in Fe(3 ) ions import. Responsible for energy coupling to the transport system
b0264	316407.85674408	1.1e-94	352.4	Escherichia		GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K07480					ko00000				Escherichia	1NHAK@1224,1RQRY@1236,3XREY@561,COG1662@1,COG1662@2	NA|NA|NA	L	Absolutely required for transposition of IS1
b0265	1443113.LC20_03235	9e-46	189.1	Yersinia													Escherichia	1N3Y7@1224,1SC0J@1236,41HER@629,COG3677@1,COG3677@2	NA|NA|NA	L	id in 91 aa, and to Shigella dysenteriae insertion element IS1 protein InsA TR
b0266	316407.85674410	2.1e-63	248.1	Gammaproteobacteria													Escherichia	1RK4X@1224,1S76P@1236,2BMAS@1,32A8G@2	NA|NA|NA	S	CbeA_antitoxin, type IV, cytoskeleton bundling-enhancing factor A
b0267	316407.85674411	7.5e-235	819.3	Gammaproteobacteria													Escherichia	1N207@1224,1S1FB@1236,COG2801@1,COG2801@2,COG3415@1,COG3415@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
b0268	316407.85674412	7.8e-171	606.3	Escherichia	yagE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019520,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0047440,GO:0071704,GO:0072329,GO:1901575	4.1.2.28	ko:K22397	ko00040,map00040		R01782	RC00307,RC00572	ko00000,ko00001,ko01000				Escherichia	1MXI1@1224,1RPXI@1236,3XQAY@561,COG0329@1,COG0329@2	NA|NA|NA	EM	Catalyze the formation of 2-keto-3-deoxy-gluconate (KDG) from pyruvate and glyceraldehyde. May also function as a 2-dehydro-3-deoxy-D-pentonate aldolase. Overexpression leads to increased growth (over 2 hours) in the presence of the antibiotics norfloxacin, ampicillin and streptomycin
b0269	316407.85674413	0.0	1323.1	Escherichia	yagF	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019520,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0050401,GO:0071704,GO:0072329,GO:1901575	4.2.1.82	ko:K22396	ko00040,map00040		R02429	RC00543	ko00000,ko00001,ko01000				Escherichia	1R4QF@1224,1RPTZ@1236,3XRJM@561,COG0129@1,COG0129@2	NA|NA|NA	E	Catalyzes the dehydration of D-xylonic acid to form 2- dehydro-3-deoxy-D-pentonate
b0270	316407.85674414	5.8e-258	896.3	Escherichia	yagG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MVUM@1224,1RP5J@1236,3XN02@561,COG2211@1,COG2211@2	NA|NA|NA	G	sodium ion transport
b0271	316407.85674415	0.0	1172.5	Escherichia	yagH		3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100		R01433	RC00467	ko00000,ko00001,ko01000		GH43		Escherichia	1NNX4@1224,1RYTM@1236,3XQRD@561,COG3507@1,COG3507@2	NA|NA|NA	G	cell wall polysaccharide metabolic process
b0272	316407.85674416	1.2e-135	489.2	Escherichia	yagI	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042710,GO:0043170,GO:0044010,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044764,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141											Escherichia	1MUNW@1224,1RR06@1236,3XP0S@561,COG1414@1,COG1414@2	NA|NA|NA	K	Transcriptional regulator
b0273	316407.85674417	2.9e-190	671.0	Escherichia	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0033554,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000			iAF1260.b0273,iECDH10B_1368.ECDH10B_0261,iJO1366.b0273,iJR904.b0273,iY75_1357.Y75_RS01410	Escherichia	1MUFM@1224,1RQ59@1236,3XM2U@561,COG0078@1,COG0078@2	NA|NA|NA	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
b4688	316407.85675488	6.5e-15	85.5	Escherichia	yfjI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N636@1224,1RZVN@1236,3XQNP@561,COG4983@1,COG4983@2	NA|NA|NA	S	Protein of unknown function (DUF3987)
b0274	316407.85674408	1.1e-94	352.4	Escherichia		GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K07480					ko00000				Escherichia	1NHAK@1224,1RQRY@1236,3XREY@561,COG1662@1,COG1662@2	NA|NA|NA	L	Absolutely required for transposition of IS1
b0275	1443113.LC20_03235	9e-46	189.1	Yersinia													Escherichia	1N3Y7@1224,1SC0J@1236,41HER@629,COG3677@1,COG3677@2	NA|NA|NA	L	id in 91 aa, and to Shigella dysenteriae insertion element IS1 protein InsA TR
b0276	316407.85674420	2.3e-136	491.5	Escherichia		GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0050896											Escherichia	1QJX4@1224,1RYVR@1236,3XQSI@561,COG1061@1,COG1061@2	NA|NA|NA	KL	type III restriction enzyme, res subunit
b0277	316407.85674421	3.2e-123	447.6	Escherichia	yagK	GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0050896											Escherichia	1MZGE@1224,1S91C@1236,2CZQX@1,32T6W@2,3XQZF@561	NA|NA|NA	S	Inovirus Gp2
b0278	316407.85674422	6.3e-128	463.4	Bacteria													Escherichia	COG1961@1,COG1961@2	NA|NA|NA	L	recombinase activity
b0279	316407.85674423	1.1e-158	565.8	Escherichia	yagM												Escherichia	1N3EQ@1224,1TGKH@1236,2C2PJ@1,32RWR@2,3XR9K@561	NA|NA|NA		
b4729	1115512.EH105704_26_00090	7.1e-25	119.4	Gammaproteobacteria													Escherichia	1P6Q8@1224,1SV9K@1236,294T7@1,2ZS6D@2	NA|NA|NA		
b0281	316407.85674425	4.3e-269	933.3	Escherichia	intF	GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0050896											Escherichia	1N2H9@1224,1RYEY@1236,3XQRM@561,COG0582@1,COG0582@2	NA|NA|NA	J	Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome
b0282	316407.85674426	6.2e-75	286.6	Gammaproteobacteria													Escherichia	1MU2E@1224,1RYUY@1236,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
b0283	316407.85674427	2.1e-182	644.8	Escherichia	yagQ	GO:0003674,GO:0005488,GO:0043546,GO:0048037,GO:0050662,GO:0097159,GO:1901363		ko:K07402					ko00000				Escherichia	1MXKU@1224,1RQRT@1236,3XP8J@561,COG1975@1,COG1975@2	NA|NA|NA	O	molybdopterin cofactor binding
b0284	316407.85674428	0.0	1423.3	Escherichia	yagR	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000				Escherichia	1MUEA@1224,1RN40@1236,3XMZP@561,COG1529@1,COG1529@2	NA|NA|NA	F	xanthine dehydrogenase activity
b0285	316407.85674429	2.5e-175	621.3	Escherichia	yagS	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000				Escherichia	1MVJS@1224,1RY6A@1236,3XP71@561,COG1319@1,COG1319@2	NA|NA|NA	F	xanthine dehydrogenase activity
b0286	316407.85674430	1.2e-126	459.1	Escherichia	yagT	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0042597,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540,GO:0055114		ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002				Escherichia	1MY3F@1224,1SYEX@1236,3XNYV@561,COG2080@1,COG2080@2	NA|NA|NA	F	Iron-sulfur subunit of the xanthine dehydrogenase complex
b0287	155864.EDL933_0318	3e-118	431.0	Escherichia	yagU	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009268,GO:0009628,GO:0010447,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K08996					ko00000				Escherichia	1MV9E@1224,1RYHM@1236,3XQGU@561,COG3477@1,COG3477@2	NA|NA|NA	S	response to acidic pH
b0288	316407.85674432	9.1e-61	239.2	Escherichia	ykgJ			ko:K06940					ko00000				Escherichia	1N027@1224,1S949@1236,3XR5H@561,COG0727@1,COG0727@2	NA|NA|NA	S	metal cluster binding
b0289	316407.85674433	3.3e-132	477.6	Gammaproteobacteria													Escherichia	1R9G7@1224,1RSAU@1236,COG3121@1,COG3121@2	NA|NA|NA	NU	Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity)
b0290	316407.85674434	0.0	1112.8	Gammaproteobacteria													Escherichia	1R4XB@1224,1RNFY@1236,28J32@1,2Z8ZC@2	NA|NA|NA	S	Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Tip pilus adhesin, which is required for assembly of EcpA into fibers (By similarity)
b0291	316407.85674435	0.0	1656.3	Gammaproteobacteria													Escherichia	1R2PY@1224,1RMJX@1236,COG3188@1,COG3188@2	NA|NA|NA	NU	Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity)
b0292	316407.85674436	2.7e-120	438.0	Gammaproteobacteria													Escherichia	1PB5I@1224,1S197@1236,COG3121@1,COG3121@2	NA|NA|NA	M	Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity)
b0293	155864.EDL933_0324	1.1e-98	365.9	Gammaproteobacteria													Escherichia	1QW80@1224,1RS9V@1236,28JUN@1,2Z9JQ@2	NA|NA|NA	S	Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Major subunit of the fimbria
b0294	316407.85674438	2.6e-106	391.3	Gammaproteobacteria													Escherichia	1NRJZ@1224,1SJJF@1236,COG2771@1,COG2771@2	NA|NA|NA	K	Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition
b4506	155864.EDL933_0328	8.9e-18	95.1	Gammaproteobacteria													Escherichia	1NGBJ@1224,1SCR7@1236,COG0257@1,COG0257@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL36 family
b0296	155864.EDL933_0329	5.2e-43	179.9	Escherichia	ykgM	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034224,GO:0042594,GO:0050896,GO:0051716,GO:0071496,GO:0120127		ko:K02909	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1MZ4D@1224,1S8V5@1236,3XPXP@561,COG0254@1,COG0254@2	NA|NA|NA	J	50S ribosomal protein L31 type B
b4630	155864.EDL933_0333	4.8e-09	65.5	Escherichia													Escherichia	1MVIX@1224,1T1RB@1236,3XPYB@561,COG1902@1,COG1902@2	NA|NA|NA	C	Oxidoreductase
b0297	316407.85674442	9e-172	609.4	Escherichia	eaeH	GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009405,GO:0016020,GO:0019867,GO:0030260,GO:0030312,GO:0030313,GO:0031975,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944		ko:K13735	ko05100,map05100				ko00000,ko00001				Escherichia	1MX9S@1224,1RPK7@1236,3XN7T@561,COG1388@1,COG1388@2	NA|NA|NA	M	cell adhesion
b0298	1440052.EAKF1_ch3017c	7.7e-43	179.5	Escherichia		GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K07483					ko00000				Escherichia	1RHBZ@1224,1S69Y@1236,3XR2P@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
b0299	316407.1736794	5.7e-171	606.7	Gammaproteobacteria													Escherichia	1MVXQ@1224,1RR4F@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
b0300	316407.85674445	3e-130	471.1	Gammaproteobacteria													Escherichia	1RIE3@1224,1S84A@1236,COG2207@1,COG2207@2,COG3708@1,COG3708@2	NA|NA|NA	K	transcriptional regulator
b0301	316407.85674446	4.4e-106	390.6	Escherichia	ykgB	GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006089,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009438,GO:0009987,GO:0010035,GO:0010467,GO:0016020,GO:0016053,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019172,GO:0019243,GO:0019249,GO:0019438,GO:0019752,GO:0032774,GO:0032787,GO:0034641,GO:0034645,GO:0034654,GO:0042180,GO:0042182,GO:0042221,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046185,GO:0046394,GO:0046483,GO:0050896,GO:0051596,GO:0061727,GO:0071704,GO:0071944,GO:0072330,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901530,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1901700		ko:K21741					ko00000				Escherichia	1R6WS@1224,1S0X7@1236,3XMGM@561,COG3059@1,COG3059@2	NA|NA|NA	S	response to hypochlorite
b0303	316407.85674447	5.7e-33	146.4	Escherichia	ykgI	GO:0000302,GO:0001101,GO:0006950,GO:0006979,GO:0008150,GO:0010035,GO:0042221,GO:0050896,GO:1901530,GO:1901700		ko:K21740					ko00000				Escherichia	1NATQ@1224,1SG5Y@1236,2EF6J@1,338ZN@2,3XR9X@561	NA|NA|NA	S	response to hypochlorite
b0304	316407.85674448	7.7e-252	875.9	Escherichia	ykgC	GO:0000302,GO:0000305,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0019725,GO:0042221,GO:0042592,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901530,GO:1901700,GO:1990748		ko:K21739					ko00000				Escherichia	1MU2U@1224,1RQTU@1236,3XMHG@561,COG1249@1,COG1249@2	NA|NA|NA	C	pyridine nucleotide-disulfide oxidoreductase
b0305	316407.85674449	3.4e-160	570.9	Escherichia	rclR	GO:0001130,GO:0001216,GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090347,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K21746					ko00000,ko03000				Escherichia	1PF5X@1224,1S0K6@1236,3XN8T@561,COG2207@1,COG2207@2	NA|NA|NA	K	Involved in reactive chlorine species (RCS) stress resistance. Upregulates, in response to hypochlorous acid (HOCl), the expression of three genes essential for survival of RCS stress (rclA, rclB and rclC) and its own expression
b0306	316407.85674450	3.9e-133	480.7	Escherichia	ykgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K18928					ko00000			iEC042_1314.EC042_0340,iEcSMS35_1347.EcSMS35_0338	Escherichia	1MWTK@1224,1RMVZ@1236,3XNA6@561,COG0247@1,COG0247@2	NA|NA|NA	C	Cysteine-rich domain
b0307	316407.85674451	1.4e-278	964.9	Escherichia	ykgF			ko:K18929					ko00000			iSF_1195.SF0259,iSFxv_1172.SFxv_0274,iS_1188.S0280	Escherichia	1MV6J@1224,1RQEA@1236,3XP0B@561,COG1139@1,COG1139@2	NA|NA|NA	C	lactate oxidation
b0308	316407.85674452	4.6e-123	447.2	Escherichia	ykgG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K00782					ko00000			iECO111_1330.ECO111_0342,iECO26_1355.ECO26_0342	Escherichia	1N67T@1224,1RNC6@1236,3XP08@561,COG1556@1,COG1556@2	NA|NA|NA	S	LUD domain
b0310	316407.85674453	6e-120	436.8	Gammaproteobacteria													Escherichia	1NTTX@1224,1SMEI@1236,2CJY1@1,33T67@2	NA|NA|NA		
b0311	316407.85674454	0.0	1167.5	Gammaproteobacteria													Escherichia	1MV19@1224,1RMD2@1236,COG2303@1,COG2303@2	NA|NA|NA	E	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
b0312	316407.85674455	1.5e-280	971.5	Gammaproteobacteria													Escherichia	1MU1V@1224,1RMBQ@1236,COG1012@1,COG1012@2	NA|NA|NA	C	belongs to the aldehyde dehydrogenase family
b0313	316407.85674456	4.5e-103	380.6	Gammaproteobacteria													Escherichia	1MX72@1224,1RZBH@1236,COG1309@1,COG1309@2	NA|NA|NA	K	Repressor involved in choline regulation of the bet genes
b0314	155864.EDL933_0363	0.0	1336.2	Gammaproteobacteria													Escherichia	1MV0K@1224,1RP3E@1236,COG1292@1,COG1292@2	NA|NA|NA	M	Belongs to the BCCT transporter (TC 2.A.15) family
b0315	316407.85674458	4.2e-211	740.3	Escherichia	yahA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0006355,GO:0008081,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042578,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071111,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	3.1.4.52	ko:K13244			R08991	RC00296	ko00000,ko01000				Escherichia	1QWBM@1224,1SNPT@1236,3XQF7@561,COG2200@1,COG2200@2,COG2771@1,COG2771@2	NA|NA|NA	K	Hydrolyzes c-di-GMP (cyclic bis(3'-5') dimeric GMP) to 5'-pGpG, known as PDE-A activity. PDE-B activity, that is hydrolysis of 5'-pGpG to GMP, proceeds only very slowly
b0316	316407.85674459	1.1e-175	622.5	Escherichia	yahB	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1P293@1224,1RNA3@1236,3XN6I@561,COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
b0317	316407.85674460	4.5e-88	330.5	Escherichia	yahC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RA3H@1224,1S33K@1236,2DC16@1,2ZCC8@2,3XMM2@561	NA|NA|NA	S	Protein of unknown function (DUF1097)
b0318	316407.85674461	2.7e-111	407.9	Escherichia	yahD	GO:0008150,GO:0009314,GO:0009628,GO:0050896		ko:K06867					ko00000				Escherichia	1N952@1224,1RPZA@1236,3XMWF@561,COG0666@1,COG0666@2	NA|NA|NA	S	response to radiation
b0319	316407.85674462	4.2e-166	590.5	Escherichia	yahE												Escherichia	1R7G4@1224,1S0VF@1236,2DBAX@1,2Z84Q@2,3XMBA@561	NA|NA|NA	S	Protein of unknown function (DUF2877)
b0320	316407.85674463	2.4e-289	1000.7	Escherichia	yahF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009361,GO:0032991,GO:0042709,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:1902494											Escherichia	1MWWN@1224,1RME7@1236,3XNEQ@561,COG0074@1,COG0074@2	NA|NA|NA	C	cofactor binding
b0321	316407.85674464	5e-273	946.4	Escherichia	yahG												Escherichia	1QWBP@1224,1T2T0@1236,3XN3J@561,COG1304@1,COG1304@2	NA|NA|NA	C	Protein of unknown function (DUF1116)
b0322	316407.85674465	1.8e-07	62.0	Escherichia	yahH												Escherichia	1QIQ5@1224,1TGJH@1236,2AV4M@1,31KUU@2,3XR7C@561	NA|NA|NA		
b0323	316407.85674466	5.3e-178	630.2	Escherichia	yahI	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200		R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000			iECSF_1327.ECSF_0300,iEcHS_1320.EcHS_A0383	Escherichia	1MWXC@1224,1RP78@1236,3XNE0@561,COG0549@1,COG0549@2	NA|NA|NA	E	Belongs to the carbamate kinase family
b0324	316407.85674467	3.4e-266	923.7	Escherichia	yahJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016810,GO:0016814,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MX34@1224,1RNSH@1236,3XMWY@561,COG0402@1,COG0402@2	NA|NA|NA	F	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
b0325	316407.85674468	4.3e-205	720.3	Escherichia	yahK	GO:0003674,GO:0003824,GO:0004033,GO:0008106,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114		ko:K13979					ko00000,ko01000				Escherichia	1MUTT@1224,1RN4D@1236,3XP1W@561,COG1064@1,COG1064@2	NA|NA|NA	S	Catalyzes the reduction of a wide range of aldehydes into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use a ketone as substrate. Is a major source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of YahK has yet to be determined
b0328	316407.85674471	1.1e-118	432.6	Escherichia	yahN	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K03329					ko00000,ko02000	2.A.76.1.3			Escherichia	1P5IT@1224,1RYYK@1236,3XMDJ@561,COG1280@1,COG1280@2	NA|NA|NA	E	amino acid transmembrane transporter activity
b0329	316407.85674472	9.6e-40	169.1	Escherichia	yahO	GO:0008150,GO:0009314,GO:0009628,GO:0050896											Escherichia	1N47F@1224,1SAJT@1236,2DN1T@1,32V0M@2,3XPVH@561	NA|NA|NA	S	response to radiation
b0330	316407.85674473	1.6e-296	1024.6	Escherichia	prpR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K02688					ko00000,ko03000				Escherichia	1NU8B@1224,1RMHY@1236,3XMTX@561,COG3829@1,COG3829@2	NA|NA|NA	K	propionate catabolism operon regulatory protein
b0331	316407.85674474	2e-158	565.1	Escherichia	prpB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046421,GO:0046459,GO:0046872,GO:0071704,GO:0072329,GO:1901575	4.1.3.30	ko:K03417	ko00640,map00640		R00409	RC00286,RC00287	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_0319,iECP_1309.ECP_0407	Escherichia	1N4VT@1224,1RMR5@1236,3XNCE@561,COG2513@1,COG2513@2	NA|NA|NA	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
b0333	316407.85674475	8.4e-226	789.3	Escherichia	prpC	GO:0003674,GO:0003824,GO:0004108,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0071704	2.3.3.5	ko:K01659	ko00640,map00640		R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000			iECED1_1282.ECED1_0365,iECIAI1_1343.ECIAI1_0334,iECIAI39_1322.ECIAI39_0347,iECP_1309.ECP_0408,iECSF_1327.ECSF_0308,iEcE24377_1341.EcE24377A_0357,iLF82_1304.LF82_1740,iNRG857_1313.NRG857_01630	Escherichia	1MUKX@1224,1RNT1@1236,3XME6@561,COG0372@1,COG0372@2	NA|NA|NA	C	Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield (2S,3S)-2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl- CoA to yield citrate but with a lower specificity
b0334	316407.85674476	8.7e-281	972.2	Escherichia	prpD	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0047547,GO:0048037,GO:0051536,GO:0051537,GO:0051540,GO:0071704	4.2.1.79	ko:K01720	ko00640,map00640		R04424	RC01152	ko00000,ko00001,ko01000			iEcolC_1368.EcolC_3291	Escherichia	1MUIG@1224,1RPQN@1236,3XNFN@561,COG2079@1,COG2079@2	NA|NA|NA	S	Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the stereospecific dehydration of (2S,3S)-2- methylcitrate (2-MC) to yield the cis isomer of 2-methyl- aconitate
b0335	316407.85674477	0.0	1285.4	Escherichia	prpE	GO:0003674,GO:0003824,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0050218	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100		R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004				Escherichia	1MUF5@1224,1RR14@1236,3XNFR@561,COG0365@1,COG0365@2	NA|NA|NA	I	Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity (By similarity)
b0336	199310.c0455	4.1e-226	790.4	Escherichia	codB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K10974					ko00000,ko02000	2.A.39.1		iECW_1372.ECW_m0414,iEKO11_1354.EKO11_3506,iEcE24377_1341.EcE24377A_0360,iWFL_1372.ECW_m0414	Escherichia	1NS07@1224,1RNHG@1236,3XQVP@561,COG1457@1,COG1457@2	NA|NA|NA	F	Required for cytosine transport into the cell
b0337	316407.85674479	1.4e-250	871.7	Escherichia	codA	GO:0003674,GO:0003824,GO:0004131,GO:0005488,GO:0005506,GO:0005515,GO:0006139,GO:0006206,GO:0006208,GO:0006209,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0019439,GO:0019858,GO:0034641,GO:0035888,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100		R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_0343,iEcSMS35_1347.EcSMS35_0368	Escherichia	1MX34@1224,1RMPF@1236,3XNWP@561,COG0402@1,COG0402@2	NA|NA|NA	F	Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5- fluorocytosine (5FC) to 5-fluorouracil (5FU)
b0338	316407.85674480	1.1e-161	575.9	Escherichia	cynR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464		ko:K11921					ko00000,ko03000				Escherichia	1NUAB@1224,1RNYQ@1236,3XQF2@561,COG0583@1,COG0583@2	NA|NA|NA	K	Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region
b0339	155864.EDL933_0399	5.1e-103	380.6	Escherichia	cynT	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009439,GO:0009440,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0034641,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:1901564,GO:1901565,GO:1901575	4.2.1.1	ko:K01673	ko00910,map00910		R00132,R10092	RC02807	ko00000,ko00001,ko01000				Escherichia	1MV1U@1224,1SYDI@1236,3XQ72@561,COG0288@1,COG0288@2	NA|NA|NA	P	Reversible hydration of carbon dioxide. Carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (CynS) diffuses out of the cell faster than it would be hydrated to bicarbonate, so the apparent function of this enzyme is to catalyze the hydration of carbon dioxide and thus prevent depletion of cellular bicarbonate
b0340	316407.85674482	5.6e-80	303.5	Escherichia	cynS	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0008824,GO:0009056,GO:0009439,GO:0009440,GO:0009987,GO:0016829,GO:0016840,GO:0034641,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:1901564,GO:1901565,GO:1901575	4.2.1.104	ko:K01725	ko00910,map00910		R03546,R10079	RC00952	ko00000,ko00001,ko01000				Escherichia	1R9X0@1224,1S40B@1236,3XQZ4@561,COG1513@1,COG1513@2	NA|NA|NA	P	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
b0341	316407.85674483	1.5e-195	688.7	Gammaproteobacteria													Escherichia	1MXGT@1224,1RRH1@1236,COG2807@1,COG2807@2	NA|NA|NA	P	transporter
b0342	316407.85674484	1.2e-98	365.9	Escherichia	lacA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008374,GO:0008870,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0042802,GO:0044424,GO:0044464	2.3.1.18	ko:K00633					ko00000,ko01000				Escherichia	1PDDC@1224,1S0KA@1236,3XQK9@561,COG0110@1,COG0110@2	NA|NA|NA	S	May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell
b0343	199310.c0458	6.2e-219	766.5	Escherichia	lacY	GO:0003674,GO:0005215,GO:0005351,GO:0005402,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015154,GO:0015155,GO:0015157,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015528,GO:0015672,GO:0015766,GO:0015767,GO:0015772,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030246,GO:0030395,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0048030,GO:0051179,GO:0051234,GO:0055085,GO:0070492,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K02532					ko00000,ko02000	2.A.1.5		iAF1260.b0343,iAPECO1_1312.APECO1_1650,iB21_1397.B21_00301,iBWG_1329.BWG_3743,iE2348C_1286.E2348C_0298,iECABU_c1320.ECABU_c04330,iECBD_1354.ECBD_3314,iECB_1328.ECB_00297,iECDH10B_1368.ECDH10B_1356,iECDH1ME8569_1439.ECDH1ME8569_0330,iECD_1391.ECD_00297,iECED1_1282.ECED1_0371,iECO103_1326.ECO103_0325,iECO111_1330.ECO111_0379,iECO26_1355.ECO26_0379,iECOK1_1307.ECOK1_0335,iECP_1309.ECP_0416,iECS88_1305.ECS88_0350,iECSE_1348.ECSE_0368,iECUMN_1333.ECUMN_0386,iECW_1372.ECW_m0421,iEKO11_1354.EKO11_3499,iEcDH1_1363.EcDH1_3263,iEcE24377_1341.EcE24377A_0367,iEcSMS35_1347.EcSMS35_0374,iEcolC_1368.EcolC_3282,iJO1366.b0343,iJR904.b0343,iLF82_1304.LF82_1167,iNRG857_1313.NRG857_01660,iUMN146_1321.UM146_15590,iUMNK88_1353.UMNK88_393,iUTI89_1310.UTI89_C0370,iWFL_1372.ECW_m0421,iY75_1357.Y75_RS01770	Escherichia	1MYS9@1224,1RMRW@1236,3XN78@561,COG2223@1,COG2223@2	NA|NA|NA	P	Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Can transport lactose, melibiose, lactulose or the analog methyl- 1-thio-beta,D-galactopyranoside (TMG), but not sucrose or fructose. The substrate specificity is directed toward the galactopyranosyl moiety of the substrate
b0344	316407.85674486	0.0	2182.1	Escherichia	lacZ	GO:0000287,GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005488,GO:0005515,GO:0005575,GO:0005975,GO:0005984,GO:0005988,GO:0005990,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009341,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0031420,GO:0032991,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0046872,GO:0071704,GO:1901575,GO:1902494	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100		R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000			iAF1260.b0344,iB21_1397.B21_00302,iECBD_1354.ECBD_3313,iECB_1328.ECB_00298,iECDH1ME8569_1439.ECDH1ME8569_0331,iECD_1391.ECD_00298,iECNA114_1301.ECNA114_0327,iEcDH1_1363.EcDH1_3262,iJO1366.b0344,iJR904.b0344,iY75_1357.Y75_RS01775	Escherichia	1MVBN@1224,1RMER@1236,3XNFH@561,COG3250@1,COG3250@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 2 family
b0345	1410620.SHLA_131c000030	9.6e-192	676.0	Rhizobiaceae													Escherichia	1R47N@1224,2TV5N@28211,4BAFF@82115,COG1609@1,COG1609@2	NA|NA|NA	K	lacI family
b0346	469008.B21_00304	2.8e-151	541.2	Escherichia	mhpR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K05818					ko00000,ko03000				Escherichia	1QRZN@1224,1RYF9@1236,3XQG0@561,COG1414@1,COG1414@2	NA|NA|NA	K	Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway
b0347	316407.85674489	0.0	1139.8	Escherichia	mhpA	GO:0006066,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0019439,GO:0019622,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046395,GO:0046435,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_0329	Escherichia	1MX9R@1224,1SYDP@1236,3XQES@561,COG0654@1,COG0654@2	NA|NA|NA	CH	Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3- hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI)
b0348	155864.EDL933_0410	7.3e-180	636.3	Escherichia	mhpB	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006066,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0008198,GO:0009056,GO:0009698,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019622,GO:0019748,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046271,GO:0046395,GO:0046435,GO:0046872,GO:0046914,GO:0047070,GO:0051213,GO:0055114,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616	1.13.11.16	ko:K05713	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R04376,R06788	RC01140,RC01364	br01602,ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_0349,iECO111_1330.ECO111_0384,iECO26_1355.ECO26_0384,iECSE_1348.ECSE_0373,iECW_1372.ECW_m0426,iEKO11_1354.EKO11_3494,iEcE24377_1341.EcE24377A_0372,iEcHS_1320.EcHS_A0412,iWFL_1372.ECW_m0426	Escherichia	1MW77@1224,1RR43@1236,3XQVF@561,COG3384@1,COG3384@2	NA|NA|NA	S	Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively
b0349	316407.85674491	4.1e-169	600.5	Escherichia	mhpC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0018771,GO:0019439,GO:0019622,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046164,GO:0046395,GO:0046435,GO:0052823,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616	3.7.1.14	ko:K05714	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R02603,R06789	RC00752,RC00753,RC01337	br01602,ko00000,ko00001,ko00002,ko01000			iECDH10B_1368.ECDH10B_1361	Escherichia	1MVTG@1224,1T1TK@1236,3XQ5Y@561,COG0596@1,COG0596@2	NA|NA|NA	S	Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6- oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid
b0350	316407.85674492	4e-150	537.3	Escherichia	mhpD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0008150,GO:0008152,GO:0008684,GO:0009056,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914	4.2.1.80	ko:K02554	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R02601,R04781	RC00750,RC01213	br01602,ko00000,ko00001,ko00002,ko01000			iECO111_1330.ECO111_0386,iECO26_1355.ECO26_0386,iECW_1372.ECW_m0428,iEKO11_1354.EKO11_3492,iEcE24377_1341.EcE24377A_0374,iEcHS_1320.EcHS_A0414,iWFL_1372.ECW_m0428	Escherichia	1MVVV@1224,1RMZ4@1236,3XQGF@561,COG3971@1,COG3971@2	NA|NA|NA	Q	Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid
b0351	316407.85674493	2.8e-171	607.8	Escherichia	mhpF	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008774,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.10	ko:K04073	ko00360,ko00362,ko00620,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,map00360,map00362,map00620,map00621,map00622,map00650,map01100,map01120,map01220	M00545,M00569	R00228,R01172	RC00004,RC00184,RC01195	br01602,ko00000,ko00001,ko00002,ko01000			iECO26_1355.ECO26_0387	Escherichia	1MV23@1224,1RNDJ@1236,3XQHY@561,COG4569@1,COG4569@2	NA|NA|NA	Q	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of
b0352	316407.85674494	7.6e-191	672.9	Escherichia	mhpE	GO:0003674,GO:0003824,GO:0008701,GO:0016829,GO:0016830,GO:0016833	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_0326,iEcSMS35_1347.EcSMS35_0383	Escherichia	1MVQG@1224,1RPPW@1236,3XQEH@561,COG0119@1,COG0119@2	NA|NA|NA	E	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of
b0353	316407.85674495	3.5e-211	740.7	Escherichia	mhpT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K05819					ko00000,ko02000	2.A.1.15		iECO26_1355.ECO26_0389	Escherichia	1MVQQ@1224,1RXX6@1236,3XQD8@561,COG0477@1,COG2814@2	NA|NA|NA	P	Uptake of 3-(3-hydroxyphenyl)propionate (3HPP) across the cytoplasmic membrane. Transport is driven by the proton motive force. Does not transport benzoate, 3-hydroxybenzoate or gentisate
b0354	316407.85674496	5.3e-58	230.7	Escherichia	yaiL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09912					ko00000			iECW_1372.ECW_m0432,iWFL_1372.ECW_m0432	Escherichia	1N15V@1224,1S5V0@1236,3XMK2@561,COG3122@1,COG3122@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2058)
b0355	316407.85674497	3.2e-163	580.9	Escherichia	frmB	GO:0003674,GO:0003824,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0016999,GO:0017144,GO:0018738,GO:0044237,GO:0044281,GO:0046292,GO:0071704	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200		R00527	RC00167,RC00320	ko00000,ko00001,ko01000		CE1	iAF1260.b0355,iBWG_1329.BWG_0244,iECDH10B_1368.ECDH10B_0310,iECDH1ME8569_1439.ECDH1ME8569_0342,iEcDH1_1363.EcDH1_3251,iG2583_1286.G2583_0468,iJO1366.b0355,iY75_1357.Y75_RS01830	Escherichia	1MUID@1224,1RMR3@1236,3XP8I@561,COG0627@1,COG0627@2	NA|NA|NA	S	Serine hydrolase involved in the detoxification of formaldehyde
b0356	316407.85674498	3.4e-216	757.3	Escherichia	frmA	GO:0003674,GO:0003824,GO:0004022,GO:0004024,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017001,GO:0017144,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046292,GO:0046294,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0051903,GO:0055114,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:0110095,GO:0110096,GO:1901575,GO:1901700,GO:1901701,GO:1990748	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204		R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000			iEC042_1314.EC042_0393,iEC55989_1330.EC55989_0365,iECH74115_1262.ECH74115_0431,iECIAI1_1343.ECIAI1_0357,iECIAI39_1322.ECIAI39_0322,iECO103_1326.ECO103_0338,iECO111_1330.ECO111_0392,iECO26_1355.ECO26_0392,iECSE_1348.ECSE_0381,iECSP_1301.ECSP_0420,iECUMN_1333.ECUMN_0399,iECW_1372.ECW_m0434,iECs_1301.ECs0411,iEKO11_1354.EKO11_3486,iETEC_1333.ETEC_0412,iEcE24377_1341.EcE24377A_0381,iEcHS_1320.EcHS_A0421,iEcolC_1368.EcolC_3269,iG2583_1286.G2583_0469,iSSON_1240.SSON_0335,iSbBS512_1146.SbBS512_E0271,iUMNK88_1353.UMNK88_407,iWFL_1372.ECW_m0434,iZ_1308.Z0456	Escherichia	1MUK4@1224,1RNQ4@1236,3XM3K@561,COG1062@1,COG1062@2	NA|NA|NA	C	Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent
b0357	1440052.EAKF1_ch1073	7.9e-42	176.0	Escherichia	frmR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141											Escherichia	1N6ZN@1224,1S6I2@1236,3XQ3V@561,COG1937@1,COG1937@2	NA|NA|NA	K	Repressor of the frmRAB operon
b0358	316407.85674500	8.5e-150	536.2	Escherichia	yaiO	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944											Escherichia	1N090@1224,1S8RC@1236,2CK01@1,32SB7@2,3XQEF@561	NA|NA|NA		
b4579	362663.ECP_0424	6.5e-72	276.6	Escherichia													Escherichia	1RI4T@1224,1S8MP@1236,3XR2D@561,COG1208@1,COG1208@2	NA|NA|NA	JM	Bacterial transferase hexapeptide (six repeats)
b0360	1440052.EAKF1_ch0283	7.2e-59	233.0	Escherichia													Escherichia	1N0V0@1224,1S7WV@1236,3XRHH@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
b0361	316407.2447044	3.9e-178	630.6	Gammaproteobacteria													Escherichia	1MY62@1224,1RQSR@1236,COG2801@1,COG2801@2	NA|NA|NA	L	cog cog2801
b0363	316407.85674504	1.9e-233	814.7	Escherichia	yaiP	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1R4DW@1224,1S1XD@1236,3XQC3@561,COG1215@1,COG1215@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
b0364	316407.85674505	3.7e-99	367.5	Escherichia	yaiS												Escherichia	1MUTM@1224,1S7I4@1236,3XQ7I@561,COG2120@1,COG2120@2	NA|NA|NA	S	hydrolase activity
b0365	316407.85674506	3.8e-176	624.0	Escherichia	tauA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009970,GO:0009987,GO:0009991,GO:0015711,GO:0015734,GO:0015849,GO:0030288,GO:0030313,GO:0031667,GO:0031668,GO:0031669,GO:0031975,GO:0033554,GO:0042594,GO:0042597,GO:0042908,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071496,GO:0071702,GO:0071705,GO:0072348		ko:K15551	ko00920,ko02010,map00920,map02010	M00435			ko00000,ko00001,ko00002,ko02000	3.A.1.17.1,3.A.1.17.4		iECOK1_1307.ECOK1_0347,iECS88_1305.ECS88_0362,iUMN146_1321.UM146_15535	Escherichia	1MVH2@1224,1RRRT@1236,3XM4M@561,COG4521@1,COG4521@2	NA|NA|NA	P	Sulfate starvation-induced protein 1
b0366	316407.85674507	3.5e-140	504.2	Escherichia	tauB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0006950,GO:0007154,GO:0008144,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0017076,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0035639,GO:0036094,GO:0042594,GO:0043167,GO:0043168,GO:0050896,GO:0051716,GO:0071496,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.36	ko:K10831	ko00920,ko02010,map00920,map02010	M00435			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.1,3.A.1.17.4		iE2348C_1286.E2348C_0306,iEcHS_1320.EcHS_A0430	Escherichia	1QTUA@1224,1RPAF@1236,3XMKD@561,COG4525@1,COG4525@2	NA|NA|NA	P	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
b0367	316407.85674508	2.2e-143	515.0	Escherichia	tauC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0042908,GO:0042910,GO:0042918,GO:0042959,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071496,GO:0071944		ko:K15552	ko00920,ko02010,map00920,map02010	M00435			ko00000,ko00001,ko00002,ko02000	3.A.1.17.1,3.A.1.17.4		iAPECO1_1312.APECO1_1637,iECOK1_1307.ECOK1_0349,iECS88_1305.ECS88_0364,iUMN146_1321.UM146_15525,iUTI89_1310.UTI89_C0386	Escherichia	1MWDJ@1224,1RQ0A@1236,3XN2Z@561,COG0600@1,COG0600@2	NA|NA|NA	P	Taurine transport system permease protein
b0368	316407.85674509	3.5e-165	587.4	Escherichia	tauD	GO:0000907,GO:0000908,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0044237,GO:0044248,GO:0044273,GO:0044424,GO:0044464,GO:0051213,GO:0055114	1.14.11.17	ko:K03119	ko00430,ko00920,map00430,map00920		R05320	RC01331	ko00000,ko00001,ko01000			iB21_1397.B21_00322,iECBD_1354.ECBD_3293,iECB_1328.ECB_00318,iECD_1391.ECD_00318,iECH74115_1262.ECH74115_0443,iECSP_1301.ECSP_0431,iECs_1301.ECs0422,iETEC_1333.ETEC_0422,iEcolC_1368.EcolC_3260,iG2583_1286.G2583_0480,iZ_1308.Z0467	Escherichia	1MV5K@1224,1RQRU@1236,3XMGN@561,COG2175@1,COG2175@2	NA|NA|NA	Q	Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme
b0369	155864.EDL933_0430	1.4e-178	632.1	Escherichia	hemB	GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147			iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,ic_1306.c0477	Escherichia	1MWMW@1224,1RP6Q@1236,3XNM2@561,COG0113@1,COG0113@2	NA|NA|NA	H	Belongs to the ALAD family
b4580	316407.85674512	1.8e-270	937.9	Escherichia													Escherichia	1R5PB@1224,1RNAE@1236,3XQ9D@561,COG3468@1,COG3468@2	NA|NA|NA	MU	Autotransporter beta-domain
b0372	316407.1736794	5.7e-171	606.7	Gammaproteobacteria													Escherichia	1MVXQ@1224,1RR4F@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
b0373	1440052.EAKF1_ch3017c	7.7e-43	179.5	Escherichia		GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K07483					ko00000				Escherichia	1RHBZ@1224,1S69Y@1236,3XR2P@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
b0375	155864.EDL933_0432	1.2e-114	419.1	Escherichia	iprA												Escherichia	1PAMQ@1224,1RSN8@1236,3XPT3@561,COG0664@1,COG0664@2	NA|NA|NA	K	Involved in oxidative stress resistance
b0376	155864.EDL933_0433	8.9e-220	769.2	Escherichia	ampH	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0005488,GO:0006022,GO:0006026,GO:0006027,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008360,GO:0008658,GO:0009056,GO:0009057,GO:0009253,GO:0016787,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031406,GO:0033218,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044238,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0070011,GO:0071704,GO:0097159,GO:0140096,GO:1901135,GO:1901136,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901681	3.4.16.4	ko:K18988					ko00000,ko01000,ko01002,ko01011				Escherichia	1MVPR@1224,1RPF1@1236,3XNM5@561,COG1680@1,COG1680@2	NA|NA|NA	M	Hydrolyzes the cross-linked dimers tetrapentapeptide (D45) and tetratetrapeptide (D44). Removes the terminal D-alanine from muropeptides and disaccharide pentapeptide M5 with a C- terminal D-Ala-D-Ala dipeptide. Associated with recycling and remodeling of peptidoglycan (PG)
b0377	155864.EDL933_0435	4.2e-228	797.0	Escherichia	sbmA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015291,GO:0015638,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0019534,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0042884,GO:0042885,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901998,GO:1904680		ko:K17938					ko00000,ko02000	9.A.18.1			Escherichia	1QU39@1224,1T1PR@1236,3XMQV@561,COG1133@1,COG1133@2	NA|NA|NA	U	Uptake of antimicrobial peptides. Required for the transport of microcin B17 (MccB17), microcin 25 (Mcc25) and proline-rich antimicrobial peptides into the cell
b0378	316407.85674519	2.2e-204	718.0	Escherichia	yaiW	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009279,GO:0010033,GO:0010243,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031240,GO:0031975,GO:0042221,GO:0044424,GO:0044425,GO:0044444,GO:0044462,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:1901652,GO:1901698,GO:1901700											Escherichia	1MVDT@1224,1RQ61@1236,28HWK@1,2Z82H@2,3XNC1@561	NA|NA|NA	S	response to peptide
b0379	155864.EDL933_0437	2.5e-52	211.1	Escherichia	yaiY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MZ02@1224,1S9IH@1236,2CHSJ@1,32S6F@2,3XPWK@561	NA|NA|NA	S	Protein of unknown function (DUF2755)
b0380	155864.EDL933_0438	4.6e-34	149.8	Escherichia	yaiZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1N38Y@1224,1SA26@1236,2CZ6J@1,32T5P@2,3XQ1G@561	NA|NA|NA	S	Protein of unknown function (DUF2754)
b0381	155864.EDL933_0439	1.2e-205	722.2	Escherichia	ddlA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008716,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464,GO:0050896	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502		R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011			iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477	Escherichia	1MUTB@1224,1RMTM@1236,3XP25@561,COG1181@1,COG1181@2	NA|NA|NA	F	Cell wall formation
b0382	155864.EDL933_0442	1.7e-38	164.9	Escherichia	iraP	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010628,GO:0016036,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042176,GO:0042177,GO:0042594,GO:0043856,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051248,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141											Escherichia	1N3ZW@1224,1SB6X@1236,2CMK9@1,32SF1@2,3XPWF@561	NA|NA|NA	J	Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway
b0383	316407.85674524	4.5e-266	923.3	Escherichia	phoA	GO:0000287,GO:0003674,GO:0003824,GO:0004035,GO:0004721,GO:0005488,GO:0005575,GO:0005623,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016491,GO:0016695,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0030288,GO:0030313,GO:0030613,GO:0031975,GO:0033748,GO:0036211,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0140096,GO:1901564	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147			iECO111_1330.ECO111_0413,iECO26_1355.ECO26_0416	Escherichia	1MXI2@1224,1RNG8@1236,3XP3C@561,COG1785@1,COG1785@2	NA|NA|NA	P	Belongs to the alkaline phosphatase family
b0384	155864.EDL933_0444	7.8e-25	119.8	Escherichia	psiF												Escherichia	1N7N3@1224,1S6R3@1236,2E4IS@1,32ZDU@2,3XPNN@561	NA|NA|NA	S	psiF repeat
b0385	199310.c0492	8.3e-207	726.1	Escherichia	adrA	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621	2.7.7.65	ko:K18968	ko02026,map02026				ko00000,ko00001,ko01000,ko02000	9.B.34.1.2		iECSF_1327.ECSF_0346,ic_1306.c0492	Escherichia	1MZV7@1224,1RPR0@1236,3XN7R@561,COG2199@1,COG3706@2	NA|NA|NA	T	diguanylate cyclase. The last member of a cascade of expressed proteins, its expression requires YdaM. AdrA production induces biosynthesis of cellulose in some E.coli isolates, but not in K12 strains. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
b0386	198214.SF0322	4.7e-143	513.8	Gammaproteobacteria													Escherichia	1R5J1@1224,1RNQK@1236,COG0345@1,COG0345@2	NA|NA|NA	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
b0387	155864.EDL933_0447	4.6e-79	300.4	Escherichia	yaiI			ko:K09768					ko00000				Escherichia	1RCZA@1224,1S3QM@1236,3XN72@561,COG1671@1,COG1671@2	NA|NA|NA	S	Belongs to the UPF0178 family
b0388	199310.c0495	1.6e-91	342.0	Escherichia	aroL	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1620,iECOK1_1307.ECOK1_0367,iECS88_1305.ECS88_0383,iUMN146_1321.UM146_15425,iUTI89_1310.UTI89_C0407	Escherichia	1RDCT@1224,1S7WF@1236,3XPSB@561,COG0703@1,COG0703@2	NA|NA|NA	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
b0389	155864.EDL933_0449	1.8e-29	134.4	Escherichia	yaiA												Escherichia	1NA4W@1224,1SE9W@1236,2E4SC@1,32ZKT@2,3XQ2V@561	NA|NA|NA	S	YaiA protein
b0390	198214.SF0326	9.8e-118	429.5	Gammaproteobacteria													Escherichia	1R3SB@1224,1RQJ0@1236,COG4126@1,COG4126@2	NA|NA|NA	E	AroM protein
b0391	155864.EDL933_0451	5.4e-46	189.9	Escherichia	ppnP	GO:0003674,GO:0003824,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016154,GO:0016740,GO:0016757,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240		R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000				Escherichia	1MZ8N@1224,1S9G3@1236,3XPUX@561,COG3123@1,COG3123@2	NA|NA|NA	S	Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions
b0392	316407.85674533	6.8e-43	179.9	Gammaproteobacteria													Escherichia	1NXN5@1224,1SQ2Q@1236,2EWBD@1,341YA@2	NA|NA|NA	S	Protein of unknown function (DUF2773)
b0393	316407.85674534	1.3e-165	589.0	Escherichia	rdgC	GO:0000018,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009295,GO:0019219,GO:0019222,GO:0031323,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363		ko:K03554					ko00000,ko03400				Escherichia	1MXPR@1224,1RMNN@1236,3XN1U@561,COG2974@1,COG2974@2	NA|NA|NA	J	May be involved in recombination
b0394	481805.EcolC_3238	2.9e-173	614.4	Escherichia	mak	GO:0003674,GO:0003824,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100		R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000			iECSE_1348.ECSE_0415,iEcHS_1320.EcHS_A0462,iS_1188.S0338	Escherichia	1MU94@1224,1RQ3P@1236,3XNWZ@561,COG1940@1,COG1940@2	NA|NA|NA	GK	Catalyzes the phosphorylation of fructose to fructose-6- P. Has also low level glucokinase activity in vitro. Is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine
b0396	316407.85674536	8.8e-207	726.1	Gammaproteobacteria													Escherichia	1MU9G@1224,1RRZF@1236,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b0397	316407.85674537	0.0	1654.4	Escherichia	sbcC	GO:0000014,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1990238		ko:K03546					ko00000,ko03400				Escherichia	1MVTQ@1224,1RQFM@1236,3XMMJ@561,COG0419@1,COG0419@2	NA|NA|NA	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
b0398	155864.EDL933_0459	4.4e-230	803.5	Escherichia	sbcD	GO:0000014,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1990238		ko:K03547					ko00000,ko03400				Escherichia	1MVV6@1224,1RP83@1236,3XN92@561,COG0420@1,COG0420@2	NA|NA|NA	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity
b0399	1440052.EAKF1_ch1041c	3.3e-129	467.6	Escherichia	phoB	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141		ko:K07657	ko02020,map02020	M00434			ko00000,ko00001,ko00002,ko02022				Escherichia	1MY2Z@1224,1RN41@1236,3XMTI@561,COG0745@1,COG0745@2	NA|NA|NA	K	phosphate regulon transcriptional regulatory protein PhoB
b0400	316407.85674540	1.4e-250	871.7	Escherichia	phoR	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016036,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035556,GO:0036211,GO:0042578,GO:0042594,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07636	ko02020,map02020	M00434			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1MWF3@1224,1RN0F@1236,3XN5J@561,COG5002@1,COG5002@2	NA|NA|NA	T	Phosphate regulon sensor protein PhoR
b0401	155864.EDL933_0464	9.1e-237	825.9	Escherichia	brnQ	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903785,GO:1903825,GO:1905039		ko:K03311					ko00000	2.A.26		iAF1260.b0401,iB21_1397.B21_00353,iBWG_1329.BWG_0283,iEC042_1314.EC042_0433,iECBD_1354.ECBD_3260,iECB_1328.ECB_00349,iECDH10B_1368.ECDH10B_0357,iECDH1ME8569_1439.ECDH1ME8569_0386,iECDH1ME8569_1439.EcDH1_3208,iECD_1391.ECD_00349,iECH74115_1262.ECH74115_0478,iECIAI1_1343.ECIAI1_0401,iECO103_1326.ECO103_0375,iECO111_1330.ECO111_0430,iECO26_1355.ECO26_0433,iECSE_1348.ECSE_0422,iECSP_1301.ECSP_0465,iECUMN_1333.ECUMN_0438,iECW_1372.ECW_m0470,iECs_1301.ECs0451,iEKO11_1354.EKO11_3448,iEcDH1_1363.EcDH1_3208,iEcE24377_1341.EcE24377A_0431,iEcHS_1320.EcHS_A0471,iEcolC_1368.EcolC_3232,iG2583_1286.G2583_0509,iJO1366.b0401,iJR904.b0401,iSBO_1134.SBO_0295,iSDY_1059.SDY_0336,iSSON_1240.SSON_0378,iSbBS512_1146.SbBS512_E0320,iUMNK88_1353.UMNK88_451,iWFL_1372.ECW_m0470,iY75_1357.Y75_RS02070,iZ_1308.Z0499	Escherichia	1MVIF@1224,1RR3P@1236,3XMX4@561,COG1114@1,COG1114@2	NA|NA|NA	E	Component of the transport system for branched-chain amino acids
b0402	199310.c0512	6.3e-257	892.9	Escherichia	proY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K11736					ko00000,ko02000	2.A.3.1.6			Escherichia	1MUPS@1224,1RNHF@1236,3XM77@561,COG1113@1,COG1113@2	NA|NA|NA	E	Permease that is involved in the transport across the cytoplasmic membrane of proline
b0403	316407.85674543	0.0	1290.8	Escherichia	malZ	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100		R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000		GH31	iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368	Escherichia	1MVKX@1224,1RQHM@1236,3XMY7@561,COG0366@1,COG0366@2	NA|NA|NA	G	May play a role in regulating the intracellular level of maltotriose. Cleaves glucose from the reducing end of maltotriose and longer maltodextrins with a chain length of up to 7 glucose units
b0404	316407.85674544	5.3e-112	410.2	Escherichia	acpH	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008081,GO:0008150,GO:0008152,GO:0008610,GO:0008770,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016788,GO:0019752,GO:0032787,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:0140096,GO:1901576	3.1.4.14	ko:K08682	ko00770,map00770		R01623		ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1606,iE2348C_1286.E2348C_0339,iECNA114_1301.ECNA114_0381,iECOK1_1307.ECOK1_0384,iECS88_1305.ECS88_0399,iECSF_1327.ECSF_0364,iUMN146_1321.UM146_15340,iUTI89_1310.UTI89_C0426	Escherichia	1MZ59@1224,1S9IZ@1236,3XNP7@561,COG3124@1,COG3124@2	NA|NA|NA	I	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
b0405	1440052.EAKF1_ch1034c	7e-203	713.0	Escherichia	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568					ko00000,ko01000,ko03016				Escherichia	1MUH3@1224,1RMKW@1236,3XNYX@561,COG0809@1,COG0809@2	NA|NA|NA	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
b0406	155864.EDL933_0471	1.9e-227	794.7	Escherichia	tgt	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773			R03789,R10209	RC00063	ko00000,ko01000,ko03016			iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475	Escherichia	1MUCA@1224,1RMY3@1236,3XM9H@561,COG0343@1,COG0343@2	NA|NA|NA	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
b0407	155864.EDL933_0472	1e-51	209.1	Escherichia	yajC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Escherichia	1MZT2@1224,1S9NV@1236,3XPRI@561,COG1862@1,COG1862@2	NA|NA|NA	U	The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes
b0408	198214.SF0345	0.0	1145.6	Gammaproteobacteria													Escherichia	1MV5U@1224,1RMIQ@1236,COG0342@1,COG0342@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
b0409	199310.c0519	2e-172	611.7	Escherichia	secF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03074	ko03060,ko03070,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7			Escherichia	1MU74@1224,1RNTY@1236,3XPBS@561,COG0341@1,COG0341@2	NA|NA|NA	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
b0410	155864.EDL933_0478	3.2e-64	250.8	Escherichia	yajD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1RGZQ@1224,1S5V4@1236,3XPM7@561,COG1403@1,COG1403@2	NA|NA|NA	V	endonuclease activity
b0411	155864.EDL933_0479	1.5e-179	635.2	Escherichia	tsx	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0015267,GO:0015288,GO:0015471,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0016032,GO:0019058,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030260,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0044403,GO:0044409,GO:0044419,GO:0044425,GO:0044462,GO:0044464,GO:0046718,GO:0046930,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098796,GO:1901264,GO:1901505,GO:1901642		ko:K05517					ko00000,ko02000	1.B.10		iAF1260.b0411,iAPECO1_1312.APECO1_1599,iB21_1397.B21_00363,iBWG_1329.BWG_0293,iE2348C_1286.E2348C_0346,iEC042_1314.EC042_0446,iEC55989_1330.EC55989_0420,iECABU_c1320.ECABU_c04890,iECBD_1354.ECBD_3250,iECDH10B_1368.ECDH10B_0367,iECDH1ME8569_1439.ECDH1ME8569_0396,iECD_1391.ECD_00359,iECED1_1282.ECED1_0434,iECH74115_1262.ECH74115_0493,iECIAI1_1343.ECIAI1_0411,iECIAI39_1322.ECIAI39_0268,iECNA114_1301.ECNA114_0388,iECO103_1326.ECO103_0385,iECO111_1330.ECO111_0441,iECO26_1355.ECO26_0443,iECOK1_1307.ECOK1_0391,iECP_1309.ECP_0470,iECS88_1305.ECS88_0406,iECSE_1348.ECSE_0433,iECSP_1301.ECSP_0478,iECUMN_1333.ECUMN_0449,iECW_1372.ECW_m0480,iECs_1301.ECs0464,iEKO11_1354.EKO11_3438,iETEC_1333.ETEC_0464,iEcDH1_1363.EcDH1_3198,iEcE24377_1341.EcE24377A_0442,iEcHS_1320.EcHS_A0482,iEcSMS35_1347.EcSMS35_0445,iEcolC_1368.EcolC_3222,iG2583_1286.G2583_0522,iJO1366.b0411,iLF82_1304.LF82_2328,iNRG857_1313.NRG857_01930,iSDY_1059.SDY_0323,iSFV_1184.SFV_0376,iSF_1195.SF0348,iSFxv_1172.SFxv_0388,iS_1188.S0356,iUMN146_1321.UM146_15305,iUMNK88_1353.UMNK88_461,iWFL_1372.ECW_m0480,iY75_1357.Y75_RS02125	Escherichia	1MZ2A@1224,1RMH2@1236,3XMNH@561,COG3248@1,COG3248@2	NA|NA|NA	M	Nucleoside-specific channel-forming protein Tsx
b0412	316407.85674552	9e-82	309.7	Escherichia	yajI												Escherichia	1R569@1224,1RQCG@1236,3XN74@561,COG4238@1,COG4238@2	NA|NA|NA	M	Protein of unknown function (DUF3251)
b0413	199310.c0523	1.5e-77	295.4	Escherichia	nrdR	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K07738					ko00000,ko03000				Escherichia	1RE7V@1224,1S3P9@1236,3XM7Q@561,COG1327@1,COG1327@2	NA|NA|NA	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
b0414	316407.85674554	1.1e-211	742.3	Escherichia	ribD	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008703,GO:0008835,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_00366,iECBD_1354.ECBD_3247,iECB_1328.ECB_00362,iECD_1391.ECD_00362,iECED1_1282.ECED1_0437,iECNA114_1301.ECNA114_0391,iECSF_1327.ECSF_0374,iEcolC_1368.EcolC_3219,iLF82_1304.LF82_1880,iNRG857_1313.NRG857_01945,ic_1306.c0524	Escherichia	1MUWT@1224,1RN2M@1236,3XP5Z@561,COG0117@1,COG0117@2,COG1985@1,COG1985@2	NA|NA|NA	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
b0415	1006000.GKAS_02190	1.5e-77	295.4	Gammaproteobacteria													Escherichia	1RD9J@1224,1S3WD@1236,COG0054@1,COG0054@2	NA|NA|NA	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
b0416	754331.AEME01000001_gene2891	1e-69	269.2	Escherichia	nusB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K03625					ko00000,ko03009,ko03021				Escherichia	1RHFZ@1224,1S6AJ@1236,3XPIS@561,COG0781@1,COG0781@2	NA|NA|NA	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
b0417	199310.c0528	3.1e-189	667.5	Escherichia	thiL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000			iSFV_1184.SFV_0382	Escherichia	1MU9X@1224,1RNHU@1236,3XMHS@561,COG0611@1,COG0611@2	NA|NA|NA	F	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
b0418	316407.85674558	8.3e-101	372.9	Escherichia	pgpA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100		R02029	RC00017	ko00000,ko00001,ko01000			iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iZ_1308.Z0520	Escherichia	1MZJA@1224,1S68A@1236,3XNNH@561,COG1267@1,COG1267@2	NA|NA|NA	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
b0419	316407.85674559	7.1e-186	656.4	Escherichia	yajO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564											Escherichia	1MV2Y@1224,1RNXH@1236,3XNBU@561,COG0667@1,COG0667@2	NA|NA|NA	C	thiamine metabolic process
b0420	316407.85674560	0.0	1250.7	Escherichia	dxs	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000			iEcSMS35_1347.EcSMS35_0456	Escherichia	1MUSJ@1224,1RNQD@1236,3XMYA@561,COG1154@1,COG1154@2	NA|NA|NA	F	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
b0421	316407.85674561	5.4e-164	583.6	Escherichia	ispA	GO:0003674,GO:0003824,GO:0004161,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006			iSFV_1184.SFV_0386	Escherichia	1MWNG@1224,1RMKY@1236,3XPD9@561,COG0142@1,COG0142@2	NA|NA|NA	H	Belongs to the FPP GGPP synthase family
b0422	155864.EDL933_0491	8.2e-35	152.5	Escherichia	xseB	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.6	ko:K03602	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Escherichia	1N72V@1224,1SC7N@1236,3XQ1J@561,COG1722@1,COG1722@2	NA|NA|NA	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
b0423	316407.85674563	6.4e-276	956.1	Escherichia	thiI	GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07461		ko00000,ko00001,ko01000,ko03016			iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307	Escherichia	1MWD3@1224,1RNZT@1236,3XP27@561,COG0301@1,COG0301@2,COG0607@1,COG0607@2	NA|NA|NA	F	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
b0424	316407.85674564	6.3e-105	386.7	Escherichia	yajL	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006517,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009100,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019538,GO:0022613,GO:0030091,GO:0033554,GO:0034599,GO:0036211,GO:0036524,GO:0036525,GO:0042026,GO:0042221,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901564	3.5.1.124	ko:K03152					ko00000,ko01000,ko01002				Escherichia	1N7T2@1224,1RSBI@1236,3XNCF@561,COG0693@1,COG0693@2	NA|NA|NA	S	Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, collagen, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. However, is less efficient than Hsp31 and YhbO, suggesting that YajL might be preferentially dedicated to protein repair. Displays a covalent chaperone activity with sulfenylated thiol proteins by forming mixed disulfides with members of the thiol proteome, and preferentially with sulfenylated cellular proteins, upon oxidative stress
b0425	198214.SF0362	8.1e-176	622.9	Gammaproteobacteria													Escherichia	1P0AW@1224,1RR49@1236,COG1893@1,COG1893@2	NA|NA|NA	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
b0426	1440052.EAKF1_ch1011c	2.2e-82	311.6	Escherichia	yajQ	GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K09767					ko00000				Escherichia	1RDTF@1224,1S3RU@1236,3XN7B@561,COG1666@1,COG1666@2	NA|NA|NA	S	UPF0234 protein YajQ
b0427	316407.85674567	1.3e-246	858.6	Escherichia	yajR	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944											Escherichia	1MVSH@1224,1RN70@1236,3XMNI@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b0428	199310.c0539	5.5e-161	573.5	Escherichia	cyoE	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029			iSFxv_1172.SFxv_0410	Escherichia	1MW3S@1224,1RNHC@1236,3XNIU@561,COG0109@1,COG0109@2	NA|NA|NA	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
b0429	198214.SF0370	2e-52	211.5	Gammaproteobacteria													Escherichia	1RHE5@1224,1S6KQ@1236,COG3125@1,COG3125@2	NA|NA|NA	C	cytochrome o ubiquinol oxidase
b0430	198214.SF0371	5e-113	413.7	Gammaproteobacteria													Escherichia	1MUCK@1224,1RN9D@1236,COG1845@1,COG1845@2	NA|NA|NA	C	oxidase subunit
b0431	155864.EDL933_0501	0.0	1337.4	Escherichia	cyoB	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009319,GO:0009486,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015453,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0019646,GO:0020037,GO:0022804,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0043167,GO:0043169,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901363,GO:1902494,GO:1902600	1.10.3.10	ko:K02298	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5			Escherichia	1MU7S@1224,1RPC3@1236,3XNDN@561,COG0843@1,COG0843@2	NA|NA|NA	C	Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons electron
b0432	199310.c0543	1.1e-178	632.5	Escherichia	cyoA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009486,GO:0009897,GO:0009986,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015453,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0022804,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0071575,GO:0071704,GO:0071944,GO:0072521,GO:0098552,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1902600	1.10.3.10	ko:K02297	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5		iE2348C_1286.E2348C_0367	Escherichia	1MWHZ@1224,1RP4H@1236,3XMMP@561,COG1622@1,COG1622@2	NA|NA|NA	C	Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons electron
b0433	155864.EDL933_0503	5.2e-273	946.4	Escherichia	ampG	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K08218	ko01501,map01501	M00628			ko00000,ko00001,ko00002,ko02000	2.A.1.25		iAPECO1_1312.APECO1_1578,iECOK1_1307.ECOK1_0413,iECS88_1305.ECS88_0429,iLF82_1304.LF82_0088,iNRG857_1313.NRG857_02040,iUMN146_1321.UM146_15195,iUTI89_1310.UTI89_C0457	Escherichia	1QU4X@1224,1T1ST@1236,3XN4U@561,COG2223@1,COG2223@2	NA|NA|NA	P	Probably acts as a permease in the beta-lactamase induction system and in peptidoglycan recycling
b0434	199310.c0546	1.9e-98	365.2	Escherichia	yajG			ko:K07286					ko00000				Escherichia	1MZ1N@1224,1RPG1@1236,3XNA8@561,COG3056@1,COG3056@2	NA|NA|NA	M	Uncharacterized lipoprotein
b0435	155864.EDL933_0506	8.8e-53	212.6	Escherichia	bolA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K05527					ko00000,ko03000				Escherichia	1MZG5@1224,1S91G@1236,3XPVA@561,COG0271@1,COG0271@2	NA|NA|NA	K	Transcriptional regulator that plays an important role in general stress response. Has many effects on cell morphology, cell growth and cell division. Acts by regulating the transcription of many genes, including dacA (PBP-5), dacC (PBP-6), ampC and mreB. Probably involved in the coordination of genes that adapt the cell physiology in order to enhance cell adaptation and survival under stress conditions. Essential for normal cell morphology in stationary phase and under conditions of starvation. Also regulates a complex network of genes encoding proteins related to biofilm development, and negatively modulates flagellar biosynthesis and swimming capacity. Could be a motile adhesive transcriptional switch, specifically involved in the transition between the planktonic and the attachment stage of biofilm formation. Overexpression produces round cell shape, impairs cell growth rate and induces biofilm development
b0436	155864.EDL933_0508	1.9e-234	818.1	Escherichia	tig	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564		ko:K03545					ko00000				Escherichia	1MUJP@1224,1RNZE@1236,3XM6A@561,COG0544@1,COG0544@2	NA|NA|NA	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
b0437	155864.EDL933_0509	7.9e-114	416.4	Escherichia	clpP	GO:0000502,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017171,GO:0019538,GO:0019899,GO:0030163,GO:0031597,GO:0032991,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051117,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212				ko00000,ko00001,ko01000,ko01002				Escherichia	1MV46@1224,1RNR6@1236,3XN6V@561,COG0740@1,COG0740@2	NA|NA|NA	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
b0438	155864.EDL933_0510	9.4e-239	832.4	Escherichia	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051301,GO:0051704,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369		ko:K03544	ko04112,map04112				ko00000,ko00001,ko03110				Escherichia	1MVQK@1224,1RN9N@1236,3XM4E@561,COG1219@1,COG1219@2	NA|NA|NA	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
b0439	199310.c0555	0.0	1513.0	Escherichia	lon	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.4.21.53	ko:K01338	ko04112,map04112				ko00000,ko00001,ko01000,ko01002				Escherichia	1MUV2@1224,1RPCB@1236,3XNIW@561,COG0466@1,COG0466@2	NA|NA|NA	O	Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
b0440	754331.AEME01000001_gene2867	8.1e-39	166.0	Escherichia	hupB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K03530					ko00000,ko03032,ko03036,ko03400				Escherichia	1MZ5B@1224,1S8VH@1236,3XPX1@561,COG0776@1,COG0776@2	NA|NA|NA	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
b0441	199310.c0557	2.6e-311	1074.7	Escherichia	ppiD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552	5.2.1.8	ko:K03770					ko00000,ko01000,ko03110				Escherichia	1MWV0@1224,1RMT5@1236,3XNHD@561,COG0760@1,COG0760@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins
b0442	198214.SF0387	2e-48	198.4	Gammaproteobacteria													Escherichia	1N6Q3@1224,1SC7U@1236,COG1555@1,COG1555@2	NA|NA|NA	L	Competence protein ComEA
b0443	316407.85674583	3e-66	257.7	Escherichia	fadM	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0047617,GO:0055114,GO:0071704,GO:0072329,GO:1901575		ko:K12500					ko00000,ko01000,ko01004				Escherichia	1REIH@1224,1S40Z@1236,3XPNH@561,COG0824@1,COG0824@2	NA|NA|NA	S	acyl-CoA hydrolase activity
b0444	316407.85674584	4.2e-132	477.2	Escherichia	queC		6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100		R09978	RC00959	ko00000,ko00001,ko01000,ko03016				Escherichia	1MU5V@1224,1RMG9@1236,3XNPF@561,COG0603@1,COG0603@2	NA|NA|NA	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
b0445	316407.85674585	0.0	1187.6	Escherichia	ybaE	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464											Escherichia	1PIAC@1224,1RPRW@1236,3XMBF@561,COG4533@1,COG4533@2	NA|NA|NA	S	Sugar transport-related sRNA regulator N-term
b0446	316407.85674586	5.6e-160	570.1	Escherichia	cof	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0016999,GO:0017001,GO:0017110,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042578,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576		ko:K11938					ko00000,ko01000			iEC55989_1330.EC55989_0460,iECO111_1330.ECO111_0479,iECO26_1355.ECO26_0481	Escherichia	1MXAF@1224,1RQXF@1236,3XMPP@561,COG0561@1,COG0561@2	NA|NA|NA	S	Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P)
b0447	155864.EDL933_0521	8.4e-81	306.2	Escherichia	ybaO	GO:0000096,GO:0000098,GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006351,GO:0006355,GO:0006520,GO:0006534,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016054,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0043200,GO:0043254,GO:0043436,GO:0043565,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046395,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K05800					ko00000,ko03000				Escherichia	1RDB3@1224,1S2E1@1236,3XPDQ@561,COG1522@1,COG1522@2	NA|NA|NA	K	Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L-cysteine
b0448	316407.85674588	0.0	1143.3	Escherichia	mdlA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K18889	ko02010,map02010	M00707			ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5			Escherichia	1MUBM@1224,1RMUR@1236,3XMIE@561,COG1132@1,COG1132@2	NA|NA|NA	P	ATP-binding
b0449	155864.EDL933_0523	0.0	1106.3	Escherichia	mdlB	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008144,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0033036,GO:0034040,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K18890	ko02010,map02010	M00707			ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5			Escherichia	1MUBM@1224,1RMUR@1236,3XP6P@561,COG1132@1,COG1132@2	NA|NA|NA	P	xenobiotic transmembrane transporting ATPase activity
b0450	1440052.EAKF1_ch0982c	1.4e-53	215.3	Escherichia	glnK	GO:0003674,GO:0005488,GO:0005515,GO:0006808,GO:0008150,GO:0042802,GO:0045848,GO:0048518,GO:0050789,GO:0065007		ko:K04752					ko00000				Escherichia	1RGWK@1224,1S67I@1236,3XPRC@561,COG0347@1,COG0347@2	NA|NA|NA	K	Nitrogen regulatory protein P-II
b0451	155864.EDL933_0526	2.1e-209	734.9	Escherichia	amtB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015291,GO:0015292,GO:0015669,GO:0015670,GO:0015696,GO:0015893,GO:0016020,GO:0016021,GO:0019755,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655		ko:K03320					ko00000,ko02000	1.A.11		iEcE24377_1341.EcE24377A_0487	Escherichia	1NR9F@1224,1RNKF@1236,3XP3W@561,COG0004@1,COG0004@2	NA|NA|NA	P	transporter
b0452	155864.EDL933_0527	6.1e-165	586.6	Escherichia	tesB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575		ko:K10805	ko01040,map01040				ko00000,ko00001,ko01000,ko01004			iAF1260.b0452,iB21_1397.B21_00408,iBWG_1329.BWG_0334,iEC55989_1330.EC55989_0466,iECBD_1354.ECBD_3203,iECB_1328.ECB_00404,iECDH10B_1368.ECDH10B_0408,iECDH1ME8569_1439.ECDH1ME8569_0437,iECD_1391.ECD_00404,iECH74115_1262.ECH74115_0541,iECIAI1_1343.ECIAI1_0456,iECIAI39_1322.ECIAI39_0221,iECO103_1326.ECO103_0429,iECO111_1330.ECO111_0485,iECO26_1355.ECO26_0487,iECSE_1348.ECSE_0478,iECSP_1301.ECSP_0520,iECUMN_1333.ECUMN_0492,iECW_1372.ECW_m0524,iECs_1301.ECs0506,iEKO11_1354.EKO11_3394,iETEC_1333.ETEC_0505,iEcDH1_1363.EcDH1_3157,iEcE24377_1341.EcE24377A_0488,iEcHS_1320.EcHS_A0529,iEcSMS35_1347.EcSMS35_0496,iEcolC_1368.EcolC_3163,iG2583_1286.G2583_0564,iJO1366.b0452,iSSON_1240.SSON_0440,iUMNK88_1353.UMNK88_505,iWFL_1372.ECW_m0524,iY75_1357.Y75_RS02335,iZ_1308.Z0564,ic_1306.c0571	Escherichia	1MV9R@1224,1RPFI@1236,3XMKC@561,COG1946@1,COG1946@2	NA|NA|NA	I	acyl-CoA thioesterase II
b0453	316407.85674593	1.2e-92	345.9	Escherichia	ybaY			ko:K09914					ko00000				Escherichia	1N8AF@1224,1SCM7@1236,3XNRM@561,COG3126@1,COG3126@2	NA|NA|NA	S	Type III secretion system lipoprotein chaperone (YscW)
b0454	316407.85674594	4.8e-69	266.9	Escherichia	ybaZ	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363		ko:K07443					ko00000				Escherichia	1N7J2@1224,1SCIZ@1236,3XPUB@561,COG3695@1,COG3695@2	NA|NA|NA	L	Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine and larger O(6)-alkylguanine adducts, and to double-stranded DNA that contains an AP (apurinic apyrimidinic) site. Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation, which allows processing by repair proteins. Works in partnership with the nucleotide excision repair (NER) pathway to enhance the repair of the O(6)-alkylguanine adducts larger than the methyl adduct. Also prevents methyl-directed mismatch repair (MMR)-mediated attack of the O(6)-alkylguanine T mispairs for the larger alkyl groups
b0456	155864.EDL933_0531	9.7e-61	239.2	Escherichia	ybaA												Escherichia	1RHC1@1224,1S6KT@1236,3XPSZ@561,COG5507@1,COG5507@2	NA|NA|NA	S	Protein of unknown function (DUF1428)
b0457	316407.85674596	1.1e-300	1038.5	Escherichia	ylaB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008081,GO:0016020,GO:0016787,GO:0016788,GO:0042578,GO:0044464,GO:0071111,GO:0071944											Escherichia	1MVTH@1224,1RMDP@1236,3XP29@561,COG4943@1,COG4943@2	NA|NA|NA	T	May function as a c-di-GMP phosphodiesterase. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria (By similarity)
b0458	155864.EDL933_0533	3.9e-81	307.4	Escherichia	ylaC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RIZ1@1224,1S7K3@1236,2CEAX@1,328KF@2,3XPGN@561	NA|NA|NA	S	Inner membrane protein YlaC
b0459	316407.85674598	8e-86	323.2	Escherichia	maa	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008374,GO:0008925,GO:0009987,GO:0016043,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0022607,GO:0042802,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840	2.3.1.79	ko:K00661					ko00000,ko01000			iAPECO1_1312.APECO1_15532,iECOK1_1307.ECOK1_0441,iECS88_1305.ECS88_0456,iUMN146_1321.UM146_15065,iUTI89_1310.UTI89_C0486	Escherichia	1RA2T@1224,1S3ZZ@1236,3XNX0@561,COG0110@1,COG0110@2	NA|NA|NA	S	Maltose O-acetyltransferase
b0460	1115512.EH105704_01_09350	4e-33	146.7	Escherichia	hha	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0010468,GO:0019222,GO:0032879,GO:0040012,GO:0040017,GO:0043900,GO:0043901,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051272,GO:0060255,GO:0065007,GO:1900190,GO:1900191,GO:2000145,GO:2000147		ko:K05839					ko00000,ko02048				Escherichia	1MZDE@1224,1S995@1236,2CN5N@1,32SGA@2,3XPZ9@561	NA|NA|NA	K	Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS StpA and may also modulate the oligomerization of the H-NS StpA-complex. Binds DNA and influences DNA topology in response to environmental stimuli
b0461	155864.EDL933_0536	3.9e-68	263.8	Escherichia	tomB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008150,GO:0009987,GO:0042710,GO:0044010,GO:0044764,GO:0051704,GO:0097159,GO:1901363		ko:K19162					ko00000,ko02048				Escherichia	1RA3M@1224,1S20M@1236,28PF7@1,2ZC6G@2,3XPMI@561	NA|NA|NA	L	Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA
b0462	316407.85674601	0.0	1990.3	Escherichia	acrB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015307,GO:0015318,GO:0015672,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1902495,GO:1902600,GO:1990281,GO:1990351		ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2			Escherichia	1MU48@1224,1RMBN@1236,3XP4C@561,COG0841@1,COG0841@2	NA|NA|NA	V	efflux pump
b0463	316407.85674602	5.8e-214	750.0	Escherichia	acrA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0006869,GO:0008150,GO:0010876,GO:0015238,GO:0015711,GO:0015718,GO:0015721,GO:0015849,GO:0015850,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098796,GO:1902495,GO:1990281,GO:1990351		ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718			ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6		iSDY_1059.SDY_0456	Escherichia	1MU78@1224,1RPI1@1236,3XM5Z@561,COG0845@1,COG0845@2	NA|NA|NA	M	AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together
b0464	198214.SF0409	7.9e-117	426.4	Gammaproteobacteria													Escherichia	1N659@1224,1RPXN@1236,COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
b0465	316407.85674604	0.0	2012.3	Escherichia	kefA	GO:0005575,GO:0005623,GO:0005886,GO:0006884,GO:0008150,GO:0008361,GO:0009987,GO:0009992,GO:0016020,GO:0016043,GO:0019725,GO:0030104,GO:0032535,GO:0042592,GO:0044464,GO:0048878,GO:0055082,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066		ko:K05802					ko00000,ko02000	1.A.23.1.1			Escherichia	1MWSA@1224,1RMYY@1236,3XMHD@561,COG1196@1,COG1196@2,COG3264@1,COG3264@2	NA|NA|NA	DM	Mechanosensitive channel that opens in response to membrane tension and specific ionic conditions. Requires high concentrations of external K( ), NH(4)( ), Rb( ) or Cs( ) to gate. May participate in the regulation of osmotic pressure changes within the cell, although it does not appear to have a major role in osmolarity regulation. Forms an ion channel of 1.0 nanosiemens conductance. The channel can remain active for between 30 seconds and over 3 minutes
b0466	316407.85674605	5.5e-19	99.4	Escherichia	ybaM	GO:0006950,GO:0008150,GO:0009987,GO:0033554,GO:0036460,GO:0050896,GO:0051716											Escherichia	1NGAT@1224,1SGE4@1236,2EHYU@1,33BQB@2,3XQ3N@561	NA|NA|NA	S	cellular response to cell envelope stress
b0467	316407.85674606	1.4e-87	328.9	Escherichia	priC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576		ko:K04067	ko03440,map03440				ko00000,ko00001,ko03400				Escherichia	1RIA6@1224,1S5VE@1236,3XMRC@561,COG3923@1,COG3923@2	NA|NA|NA	L	Primosomal replication protein N'
b0468	155864.EDL933_0543	2.2e-63	248.1	Escherichia	ybaN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K09790					ko00000				Escherichia	1N7BI@1224,1SCJZ@1236,3XPP0@561,COG2832@1,COG2832@2	NA|NA|NA	S	membrane
b0469	199310.c0588	7e-98	363.2	Escherichia	apt	GO:0000287,GO:0003674,GO:0003824,GO:0003999,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0042802,GO:0043094,GO:0043096,GO:0043101,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100		R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147			iUTI89_1310.UTI89_C0496,ic_1306.c0588	Escherichia	1MVZ6@1224,1S2N9@1236,3XNWM@561,COG0503@1,COG0503@2	NA|NA|NA	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
b0470	316407.85674609	0.0	1192.2	Escherichia	dnaX	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Escherichia	1MVCK@1224,1RMIA@1236,3XNC3@561,COG2812@1,COG2812@2	NA|NA|NA	F	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits
b0471	1005994.GTGU_01283	2.5e-42	177.9	Gammaproteobacteria													Escherichia	1RGZD@1224,1S5WU@1236,COG0718@1,COG0718@2	NA|NA|NA	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
b0472	155864.EDL933_0547	1.3e-110	405.6	Escherichia	recR	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576		ko:K06187	ko03440,map03440				ko00000,ko00001,ko03400				Escherichia	1MV9Q@1224,1RN99@1236,3XM8A@561,COG0353@1,COG0353@2	NA|NA|NA	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
b0473	155864.EDL933_0548	0.0	1227.2	Escherichia	htpG	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716		ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418				ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147				Escherichia	1MUUE@1224,1RNWD@1236,3XNBQ@561,COG0326@1,COG0326@2	NA|NA|NA	O	Molecular chaperone. Has ATPase activity
b0474	155864.EDL933_0550	2.3e-116	424.9	Escherichia	adk	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004017,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006412,GO:0006518,GO:0006629,GO:0006644,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0010467,GO:0015949,GO:0015950,GO:0015951,GO:0016070,GO:0016208,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019205,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147			iECH74115_1262.ECH74115_0566,iEKO11_1354.EKO11_3373,iG2583_1286.G2583_0586	Escherichia	1MXCZ@1224,1RMT6@1236,3XP7G@561,COG0563@1,COG0563@2	NA|NA|NA	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
b0475	316407.85674614	9.1e-186	656.0	Escherichia	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1540,iECS88_1305.ECS88_0472	Escherichia	1MVR1@1224,1RMMS@1236,3XP5C@561,COG0276@1,COG0276@2	NA|NA|NA	H	Catalyzes the ferrous insertion into protoporphyrin IX
b0476	316407.85674615	2.3e-189	667.9	Escherichia	aes	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008126,GO:0008150,GO:0008152,GO:0009056,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0034338,GO:0043086,GO:0043433,GO:0044092,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0050790,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0051336,GO:0051346,GO:0052689,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K01066					ko00000,ko01000				Escherichia	1NEXK@1224,1RY94@1236,3XPGA@561,COG0657@1,COG0657@2	NA|NA|NA	I	Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity
b0477	155864.EDL933_0553	7.9e-257	892.5	Escherichia	gsk	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008906,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237	2.7.1.73	ko:K00892	ko00230,map00230		R01131,R01228	RC00002,RC00017	ko00000,ko00001,ko01000			iSDY_1059.SDY_0442	Escherichia	1MUUC@1224,1RMN2@1236,3XMG2@561,COG0524@1,COG0524@2	NA|NA|NA	F	inosine kinase activity
b0478	316407.85674617	1.2e-294	1018.5	Escherichia	ybaL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03455					ko00000	2.A.37			Escherichia	1MV34@1224,1RMM7@1236,3XM64@561,COG1226@1,COG1226@2,COG4651@1,COG4651@2	NA|NA|NA	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
b0479	316407.85674618	4.4e-217	760.4	Escherichia	fsr	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944		ko:K08223					ko00000,ko02000	2.A.1.35			Escherichia	1MXAA@1224,1RMZZ@1236,3XP1S@561,COG2223@1,COG2223@2	NA|NA|NA	P	Fosmidomycin resistance protein
b0480	316407.85674619	0.0	1117.8	Escherichia	ushA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008768,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0030288,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046872	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_0493,iECIAI1_1343.ECIAI1_0483,iECO103_1326.ECO103_0456,iECSE_1348.ECSE_0505	Escherichia	1MX03@1224,1RPX3@1236,3XM6V@561,COG0737@1,COG0737@2	NA|NA|NA	F	Belongs to the 5'-nucleotidase family
b0481	198214.SF0426	1.2e-82	312.4	Gammaproteobacteria													Escherichia	1RGX5@1224,1S6S0@1236,COG2606@1,COG2606@2	NA|NA|NA	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
b0482	316407.85674621	2.7e-151	541.2	Escherichia	ybaP			ko:K09973					ko00000				Escherichia	1MVCW@1224,1RRI8@1236,3XN0U@561,COG3735@1,COG3735@2	NA|NA|NA	S	TraB family
b0483	155864.EDL933_0559	4.5e-55	220.3	Escherichia	ybaQ			ko:K21498					ko00000,ko02048				Escherichia	1N76J@1224,1SCYV@1236,3XQ5N@561,COG3093@1,COG3093@2	NA|NA|NA	K	sequence-specific DNA binding
b0484	316407.85674623	0.0	1549.3	Escherichia	copA	GO:0000041,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015080,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035434,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046688,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060003,GO:0061687,GO:0070887,GO:0071241,GO:0071248,GO:0071280,GO:0071292,GO:0071944,GO:0090662,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0099131,GO:1902601,GO:1990169	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016		R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5		iEC55989_1330.EC55989_0497,iECIAI1_1343.ECIAI1_0487,iECSE_1348.ECSE_0509,iECW_1372.ECW_m0557,iEKO11_1354.EKO11_3363,iWFL_1372.ECW_m0557	Escherichia	1MU08@1224,1RN2C@1236,3XNB5@561,COG2217@1,COG2217@2	NA|NA|NA	P	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily
b0485	316407.85674624	2.7e-174	617.8	Escherichia	glsA1	GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016043,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0022607,GO:0040008,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0045926,GO:0046394,GO:0046395,GO:0048519,GO:0050789,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230		R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000			e_coli_core.b0485,iAF1260.b0485,iB21_1397.B21_00441,iBWG_1329.BWG_0366,iECBD_1354.ECBD_3171,iECB_1328.ECB_00436,iECDH10B_1368.ECDH10B_0442,iECDH1ME8569_1439.ECDH1ME8569_0469,iECD_1391.ECD_00436,iECO111_1330.ECO111_0520,iETEC_1333.ETEC_0537,iEcDH1_1363.EcDH1_3125,iJO1366.b0485,iJR904.b0485,iUMNK88_1353.UMNK88_538,iY75_1357.Y75_RS02500	Escherichia	1MWB5@1224,1RMY9@1236,3XMCV@561,COG2066@1,COG2066@2	NA|NA|NA	E	Belongs to the glutaminase family
b0486	316407.85674625	2.8e-222	777.7	Escherichia	ybaT	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009268,GO:0009628,GO:0010035,GO:0010038,GO:0016020,GO:0042221,GO:0044464,GO:0046688,GO:0050896,GO:0071944,GO:0097501,GO:1990169											Escherichia	1QVWZ@1224,1T2MA@1236,3XPI4@561,COG0531@1,COG0531@2	NA|NA|NA	E	transport protein
b0487	198214.SF0432	4.1e-71	273.9	Gammaproteobacteria													Escherichia	1RGX6@1224,1S8ZG@1236,COG0789@1,COG0789@2	NA|NA|NA	K	Transcriptional regulator
b0488	481805.EcolC_3128	3.8e-81	307.4	Escherichia	ybbJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07340					ko00000				Escherichia	1N241@1224,1S5W4@1236,3XPSV@561,COG1585@1,COG1585@2	NA|NA|NA	OU	NfeD-like C-terminal, partner-binding
b0489	155864.EDL933_0577	5.7e-121	440.7	Escherichia	qmcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MUM8@1224,1RNW8@1236,3XNCK@561,COG0330@1,COG0330@2	NA|NA|NA	O	Identified as a multi-copy suppressor of an FtsH HtpX protease double disruption mutant. May play a role in the quality control of integral membrane proteins
b0490	316407.85674629	1.4e-124	452.2	Escherichia	fetA	GO:0005575,GO:0005623,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0009987,GO:0016020,GO:0019725,GO:0030003,GO:0042592,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071944,GO:0098771		ko:K02068		M00211			ko00000,ko00002,ko02000				Escherichia	1NZKM@1224,1RQ94@1236,3XPEP@561,COG4619@1,COG4619@2	NA|NA|NA	P	Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for energy coupling to the transport system
b0491	155864.EDL933_0579	1.3e-129	469.2	Escherichia	JD73_11205	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0009987,GO:0015075,GO:0016020,GO:0016021,GO:0019725,GO:0022857,GO:0030003,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098771		ko:K02069		M00211			ko00000,ko00002,ko02000	9.B.25.1			Escherichia	1MV2N@1224,1RSGA@1236,3XPB6@561,COG0390@1,COG0390@2	NA|NA|NA	S	Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for the translocation of the substrate across the membrane
b0492	316407.85674631	2.2e-151	541.6	Escherichia	ybbN	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0061077		ko:K05838					ko00000,ko03110				Escherichia	1MV0R@1224,1RMSQ@1236,3XNYC@561,COG3118@1,COG3118@2	NA|NA|NA	O	protein disulfide oxidoreductase activity
b0493	199310.c0614	6.8e-150	536.6	Escherichia	ybbO	GO:0003674,GO:0003824,GO:0004033,GO:0008106,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114											Escherichia	1RGKZ@1224,1T1HV@1236,3XPHF@561,COG0300@1,COG0300@2	NA|NA|NA	S	alcohol dehydrogenase (NADP+) activity
b0494	199310.c0615	8.5e-116	422.9	Escherichia	tesA	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564	3.1.1.5	ko:K10804	ko01040,map01040				ko00000,ko00001,ko01000,ko01004			iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365	Escherichia	1RCXZ@1224,1S3QU@1236,3XMR2@561,COG2755@1,COG2755@2	NA|NA|NA	E	TesA is a multifunctional esterase that can act as a thioesterase, lysophospholipase and protease. TesA functions as a thioesterase specific for fatty acyl thioesters of greater than ten carbons, with highest activity on palmitoyl-CoA, cis-vaccenyl-CoA and palmitoleoyl-CoA. TesA also possesses an arylesterase activity towards short acyl-chain aromatic esters such as alpha-naphthyl acetate, alpha-naphthyl butyrate, benzyl acetate and phenyl acetate. Also able to hydrolyze short acyl-chain triacylglycerols such as triacetin and tributyrin, and p- nitrophenyl esters such as p-nitrophenyl hexanoate and p- nitrophenyl butyrate. The protease activity is mainly active on small peptides. TesA is also able to hydrolyze p-nitrophenyl esters of N- substituted amino acids such as N-benzyloxycarbonyl-L-Phe-p- nitrophenyl ester (Z-L-Phe-ONp) and N-benzyloxycarbonyl-L-Tyr-p- nitrophenyl ester (Z-L-Tyr-ONp), however it is unable to hydrolyze N-acetyl-L-Phe ethyl ester and its Tyr analog. TesA also hydrolyzes N- benzyloxycarbonyl-L-Phe beta-nitrophenyl ester (Cbz-Phe-ONap) and N-acetyl-DL-Phe-2-naphthyl ester (chymotrypsin-like specificity). Shows a slow proteolytic activity against denatured casein. The lysophospholipase activity of TesA is able to hydrolyze 1- palmitoyl-sn-glycero-3-phosphocholine, 1-acyl-sn-glycero-3- phosphoglycerol, 1- and 2-acyl-sn-glycero-3-phosphoethanolamine
b0495	155864.EDL933_0583	1.1e-121	442.6	Escherichia	ybbA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K02003		M00258			ko00000,ko00002,ko02000	3.A.1			Escherichia	1MXG9@1224,1RMG1@1236,3XMIH@561,COG4181@1,COG4181@2	NA|NA|NA	P	ATP-binding protein YbbA
b0496	316407.85674635	0.0	1534.2	Escherichia	ybbP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02004		M00258			ko00000,ko00002,ko02000	3.A.1			Escherichia	1MU9R@1224,1RM8Y@1236,3XMBI@561,COG3127@1,COG3127@2	NA|NA|NA	Q	FtsX-like permease family
b0497	316407.85674636	0.0	2428.7	Escherichia	rhsD	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496											Escherichia	1MVV1@1224,1SKYM@1236,3XQWR@561,COG3209@1,COG3209@2	NA|NA|NA	M	Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell
b0498	316407.85674637	6.4e-63	246.5	Gammaproteobacteria													Escherichia	1NMGW@1224,1SGP1@1236,2EV2G@1,33NHI@2	NA|NA|NA	S	NTF2 fold immunity protein
b0499	316407.85674638	6.6e-141	506.5	Bacteria													Escherichia	COG3209@1,COG3209@2	NA|NA|NA	M	self proteolysis
b0502	155864.EDL933_0587	9.9e-64	249.2	Gammaproteobacteria													Escherichia	1MZ45@1224,1RSNX@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
b0503	316407.85674641	4.2e-211	740.3	Escherichia	selU	GO:0001887,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016785,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043828,GO:0044237,GO:0044238,GO:0046483,GO:0070329,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360		ko:K06917					ko00000,ko01000,ko03016				Escherichia	1N4T5@1224,1RPFP@1236,3XP1I@561,COG2603@1,COG2603@2	NA|NA|NA	J	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
b0504	155864.EDL933_0589	1e-173	615.9	Gammaproteobacteria													Escherichia	1P293@1224,1RNA3@1236,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
b0505	316407.85674643	3.6e-90	337.4	Escherichia	allA	GO:0003674,GO:0003824,GO:0016829,GO:0016840,GO:0016842,GO:0050385	4.3.2.3	ko:K01483	ko00230,ko01100,map00230,map01100		R00776	RC00153,RC00379	ko00000,ko00001,ko01000			iAF1260.b0505,iBWG_1329.BWG_0382,iECDH10B_1368.ECDH10B_0461,iECDH1ME8569_1439.ECDH1ME8569_0489,iEcDH1_1363.EcDH1_3107,iJO1366.b0505,iJR904.b0505,iY75_1357.Y75_RS02595	Escherichia	1RH5G@1224,1T0X7@1236,3XQTI@561,COG3194@1,COG3194@2	NA|NA|NA	F	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate
b0506	199310.c0621	3.5e-146	524.2	Escherichia				ko:K10973					ko00000,ko03000				Escherichia	1R5WB@1224,1RZAS@1236,3XQPE@561,COG1414@1,COG1414@2	NA|NA|NA	K	IclR helix-turn-helix domain
b0507	155864.EDL933_0592	0.0	1180.2	Escherichia	gcl	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006066,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009028,GO:0009056,GO:0009436,GO:0009441,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017144,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034308,GO:0034310,GO:0036094,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046185,GO:0046296,GO:0046395,GO:0046487,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0071949,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901615,GO:1901616,GO:1901681	4.1.1.47	ko:K01608	ko00630,ko01100,map00630,map01100		R00013	RC00899	ko00000,ko00001,ko01000			iEcHS_1320.EcHS_A0581,iSFV_1184.SFV_0474	Escherichia	1MV88@1224,1RW45@1236,3XQHP@561,COG3960@1,COG3960@2	NA|NA|NA	S	Catalyzes the condensation of two molecules of glyoxylate to give 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde)
b0508	316407.85674646	9.7e-154	549.3	Escherichia	hyi	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0008903,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019752,GO:0032787,GO:0042802,GO:0042803,GO:0043436,GO:0044237,GO:0044281,GO:0046487,GO:0046983,GO:0071704	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100		R01394	RC00511	ko00000,ko00001,ko01000			iECO103_1326.ECO103_0481,iECO111_1330.ECO111_0541,iECO26_1355.ECO26_0541	Escherichia	1MV53@1224,1RQF9@1236,3XQA5@561,COG3622@1,COG3622@2	NA|NA|NA	G	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). Does not catalyze the isomerization of D-fructose to D-glucose or that of D-xylulose to D-xylose. Also does not catalyze racemization of serine, alanine, glycerate or lactate
b0509	316407.85674647	2.5e-158	564.7	Escherichia	glxR	GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009436,GO:0009442,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042737,GO:0043436,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046185,GO:0046395,GO:0046483,GO:0046487,GO:0046700,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100		R01745,R01747	RC00099	ko00000,ko00001,ko01000				Escherichia	1MUGU@1224,1RQ2D@1236,3XQ73@561,COG2084@1,COG2084@2	NA|NA|NA	I	2-hydroxy-3-oxopropionate reductase
b0511	316407.85674649	2.1e-271	941.0	Escherichia	ybbW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015205,GO:0015851,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944		ko:K10975					ko00000,ko02000	2.A.39.3.8		iAPECO1_1312.APECO1_1504,iE2348C_1286.E2348C_0444,iECABU_c1320.ECABU_c05900,iECNA114_1301.ECNA114_0488,iECOK1_1307.ECOK1_0493,iECP_1309.ECP_0571,iECS88_1305.ECS88_0510,iECSF_1327.ECSF_0473,iLF82_1304.LF82_2567,iNRG857_1313.NRG857_02415,iUMN146_1321.UM146_14805,iUTI89_1310.UTI89_C0539,ic_1306.c0625	Escherichia	1MV18@1224,1RMZU@1236,3XQNS@561,COG1953@1,COG1953@2	NA|NA|NA	FH	Allantoin transport protein
b0512	316407.85674650	1.9e-269	934.5	Escherichia	allB	GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0004038,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009112,GO:0009442,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0017144,GO:0019439,GO:0034641,GO:0042737,GO:0043167,GO:0043169,GO:0043603,GO:0043605,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_0555	Escherichia	1MW10@1224,1RMQC@1236,3XQC8@561,COG0044@1,COG0044@2	NA|NA|NA	F	Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring
b0513	155864.EDL933_0598	1.3e-238	832.0	Escherichia	ybbY	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015851,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042906,GO:0042907,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823											Escherichia	1PD7V@1224,1RZ18@1236,3XQPF@561,COG2233@1,COG2233@2	NA|NA|NA	F	xanthine transmembrane transporter activity
b0514	316407.85674652	6.3e-210	736.5	Escherichia	glxK	GO:0003674,GO:0003824,GO:0006066,GO:0006081,GO:0006082,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009441,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0017144,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0043798,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046185,GO:0046296,GO:0046395,GO:0046487,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130		R08572	RC00002,RC00428	ko00000,ko00001,ko01000			iECO103_1326.ECO103_0486	Escherichia	1MVG9@1224,1RMC6@1236,3XMNZ@561,COG1929@1,COG1929@2	NA|NA|NA	G	Belongs to the glycerate kinase type-1 family
b0515	316407.85674653	1.7e-153	548.5	Escherichia	ylbA	GO:0003674,GO:0003824,GO:0005488,GO:0016787,GO:0016810,GO:0016813,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0071522	3.5.3.26	ko:K14977	ko00230,ko01120,map00230,map01120		R05554	RC01419	ko00000,ko00001,ko01000				Escherichia	1MW60@1224,1RQFK@1236,3XQS8@561,COG3257@1,COG3257@2	NA|NA|NA	S	Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes the second stereospecific hydrolysis reaction (deamination) of the allantoin degradation pathway, producing S-ureidoglycolate and ammonia from S- ureidoglycine
b0516	316407.85674654	1.3e-245	855.1	Escherichia	allC	GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009442,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0017144,GO:0030145,GO:0034641,GO:0042737,GO:0043167,GO:0043169,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047652,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.3.9	ko:K02083	ko00230,ko01120,map00230,map01120		R02423	RC00064	ko00000,ko00001,ko01000,ko01002			iECH74115_1262.ECH74115_0617,iECSP_1301.ECSP_0590,iECUMN_1333.ECUMN_0556,iECs_1301.ECs0578,iZ_1308.Z0671	Escherichia	1MVUX@1224,1RPPD@1236,3XPWH@561,COG0624@1,COG0624@2	NA|NA|NA	E	Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes specifically the hydrolysis of allantoate to yield CO2, NH3 and S-ureidoglycine, which is unstable and readily undergoes a second deamination by S-ureidoglycine aminohydrolase AllE to yield S-ureidoglycolate and NH3. In vivo, the spontaneous release of S-ureidoglycolate and ammonia from S- ureidoglycine appears to be too slow to sustain an efficient flux of nitrogen
b0517	316407.85674655	4.6e-199	700.3	Escherichia	allD	GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0006807,GO:0008150,GO:0008152,GO:0009040,GO:0009056,GO:0009442,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0034641,GO:0042737,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0046483,GO:0046700,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.1.1.350	ko:K00073	ko00230,ko01120,map00230,map01120		R02935,R02936	RC00169	ko00000,ko00001,ko01000			iEC042_1314.EC042_0560	Escherichia	1MWQY@1224,1RSKW@1236,3XQXU@561,COG2055@1,COG2055@2	NA|NA|NA	C	AllD plays a pivotal role as a metabolic branch-point enzyme in nitrogen utilization via the assimilation of allantoin. It is able to utilize allantoin as a sole source of nitrogen under anaerobic conditions. Catalyzes the oxidation of ureidoglycolate to oxalurate
b0518	316407.85674656	8.7e-309	1065.4	Escherichia	fdrA	GO:0001539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006928,GO:0008150,GO:0009361,GO:0009987,GO:0032991,GO:0040011,GO:0042709,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588,GO:1902494		ko:K02381					ko00000				Escherichia	1MWWN@1224,1RME7@1236,3XQJD@561,COG0074@1,COG0074@2	NA|NA|NA	C	multicopy suppressor of dominant negative ftsH
b4572	511145.b4572	1.3e-240	838.6	Escherichia	ylbE												Escherichia	1MX67@1224,1RQEG@1236,3XQNV@561,COG0074@1,COG0074@2	NA|NA|NA	C	Protein of unknown function (DUF1116)
b0520	155864.EDL933_0605	3.6e-159	567.4	Escherichia	ylbF												Escherichia	1N0UA@1224,1S1HZ@1236,2DBVD@1,2ZBAJ@2,3XQE1@561	NA|NA|NA	S	Protein of unknown function (DUF2877)
b0521	316407.85674658	3.5e-163	580.9	Escherichia	ybcF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200		R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_0454,iECED1_1282.ECED1_0540,iECUMN_1333.ECUMN_0561,iEcE24377_1341.EcE24377A_0559,iG2583_1286.G2583_0641	Escherichia	1MWXC@1224,1RP78@1236,3XQ99@561,COG0549@1,COG0549@2	NA|NA|NA	F	Belongs to the carbamate kinase family
b0522	316407.85674659	2.5e-208	731.1	Escherichia	purK	GO:0000166,GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034028,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_0562	Escherichia	1MU70@1224,1RQEI@1236,3XN0K@561,COG0026@1,COG0026@2	NA|NA|NA	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
b0523	155864.EDL933_0608	2.3e-87	328.2	Escherichia	purE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016853,GO:0016866,GO:0034023,GO:0042802,GO:0044424,GO:0044444,GO:0044464	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000			iETEC_1333.ETEC_0575,iUTI89_1310.UTI89_C0551	Escherichia	1RCWJ@1224,1S3VN@1236,3XNQ8@561,COG0041@1,COG0041@2	NA|NA|NA	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
b0524	316407.85674661	3.8e-136	490.7	Escherichia	lpxH	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005			iE2348C_1286.E2348C_0457	Escherichia	1N3U7@1224,1RP1X@1236,3XNT3@561,COG2908@1,COG2908@2	NA|NA|NA	S	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
b0525	316407.85674662	7.4e-91	339.7	Escherichia	ppiB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03768					ko00000,ko01000,ko03110				Escherichia	1R9ZQ@1224,1S222@1236,3XMU9@561,COG0652@1,COG0652@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
b0526	316407.85674663	7.8e-271	939.1	Escherichia	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iECUMN_1333.ECUMN_0566	Escherichia	1MV8H@1224,1RP5K@1236,3XMKF@561,COG0215@1,COG0215@2	NA|NA|NA	J	Belongs to the class-I aminoacyl-tRNA synthetase family
b0527	316407.85674664	6.6e-98	363.2	Escherichia	ybcI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07038					ko00000				Escherichia	1RBHW@1224,1S2F9@1236,3XPG8@561,COG1988@1,COG1988@2	NA|NA|NA	S	LexA-binding, inner membrane-associated putative hydrolase
b0528	1440052.EAKF1_ch0925	2.2e-31	141.0	Escherichia	ybcJ	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K14761					ko00000,ko03009				Escherichia	1N7NW@1224,1SCJU@1236,3XQ0A@561,COG2501@1,COG2501@2	NA|NA|NA	S	translation
b0529	316407.85674666	1.6e-160	572.0	Escherichia	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_0281	Escherichia	1MWU4@1224,1RNSW@1236,3XMYB@561,COG0190@1,COG0190@2	NA|NA|NA	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
b0530	155864.EDL933_0615	2.1e-83	315.1	Escherichia	sfmA	GO:0007155,GO:0008150,GO:0022610		ko:K07352					ko00000,ko02035				Escherichia	1QI7Y@1224,1S07V@1236,3XQCR@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
b0531	316407.85674668	4.2e-124	450.7	Escherichia	sfmC			ko:K07353					ko00000,ko02035				Escherichia	1R3T9@1224,1RS56@1236,3XQNQ@561,COG3121@1,COG3121@2	NA|NA|NA	NU	Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
b0532	316407.85674669	0.0	1775.4	Escherichia	sfmD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944		ko:K07354					ko00000,ko02035				Escherichia	1MUHE@1224,1RMPU@1236,3XQTP@561,COG3188@1,COG3188@2	NA|NA|NA	NU	Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. Probably involved in the export and assembly of fimbrial subunits across the outer membrane
b0533	511145.b0533	1.2e-185	655.6	Escherichia	sfmH	GO:0007155,GO:0008150,GO:0022610		ko:K07356					ko00000,ko02035				Escherichia	1R5U6@1224,1RR81@1236,3XQQE@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
b0534	316407.85674671	2.2e-93	348.2	Escherichia	sfmF	GO:0007155,GO:0008150,GO:0022610		ko:K07355					ko00000,ko02035				Escherichia	1RGDK@1224,1S5NU@1236,3XQQY@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
b0535	155864.EDL933_0620	1.4e-110	405.6	Escherichia	fimZ			ko:K07688	ko02020,map02020				ko00000,ko00001,ko02022				Escherichia	1Q0DT@1224,1RY1Z@1236,3XQGX@561,COG2197@1,COG2197@2	NA|NA|NA	K	intracellular signal transduction
b0537	316407.85674673	4.1e-225	786.9	Escherichia	intD	GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0008979,GO:0009009,GO:0009987,GO:0015074,GO:0016032,GO:0019042,GO:0019043,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051704,GO:0071704,GO:0075713,GO:0090304,GO:0140097,GO:1901360											Escherichia	1MWBN@1224,1RPD0@1236,3XN2J@561,COG0582@1,COG0582@2	NA|NA|NA	L	Integrase from the cryptic lambdoic prophage DLP12. Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome
b4633	469008.B21_00492	4.6e-32	143.3	Gammaproteobacteria													Escherichia	1NEYK@1224,1SCT9@1236,2E9F5@1,333NG@2	NA|NA|NA		
b0539	316407.85674674	3.6e-44	183.7	Gammaproteobacteria													Escherichia	1QJWH@1224,1RY3Q@1236,28MEG@1,2ZAS3@2	NA|NA|NA	L	Exonuclease
b0542	155864.EDL933_1809	1.1e-08	64.3	Gammaproteobacteria													Escherichia	1NG7D@1224,1SE2F@1236,2EAS2@1,334U5@2	NA|NA|NA		
b0540	1440052.EAKF1_ch3017c	7.7e-43	179.5	Escherichia		GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K07483					ko00000				Escherichia	1RHBZ@1224,1S69Y@1236,3XR2P@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
b0541	316407.1736794	5.7e-171	606.7	Gammaproteobacteria													Escherichia	1MVXQ@1224,1RR4F@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
b0543	316407.85674678	8.9e-56	222.6	Escherichia	emrE	GO:0003674,GO:0005215,GO:0005326,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006805,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0006855,GO:0006950,GO:0006970,GO:0006974,GO:0008150,GO:0008152,GO:0008324,GO:0008519,GO:0009410,GO:0009628,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015101,GO:0015199,GO:0015220,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015307,GO:0015318,GO:0015651,GO:0015672,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0015871,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0031460,GO:0033554,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071466,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072349,GO:0072488,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K03297					ko00000,ko02000	2.A.7.1			Escherichia	1MZ54@1224,1S8SG@1236,3XPTS@561,COG2076@1,COG2076@2	NA|NA|NA	P	Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. Is involved in the resistance of E.coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP( )) and benzalkonium
b0544	316407.85674679	1.4e-289	1001.5	Escherichia	ybcK												Escherichia	1N6DV@1224,1RYWS@1236,3XQ5U@561,COG1961@1,COG1961@2	NA|NA|NA	L	recombinase activity
b0545	316407.85674680	2.1e-102	378.3	Escherichia	ybcL	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K06910					ko00000				Escherichia	1N0Y4@1224,1S400@1236,3XQFI@561,COG1881@1,COG1881@2	NA|NA|NA	S	negative regulation of catalytic activity
b0546	316407.85674681	1.1e-149	535.8	Escherichia	ybcM	GO:0003674,GO:0003700,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0033554,GO:0042221,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141											Escherichia	1R71R@1224,1RPUM@1236,3XQDD@561,COG2207@1,COG2207@2	NA|NA|NA	K	response to antibiotic
b0547	316407.85674682	2.8e-84	317.8	Escherichia	ybcN	GO:0000217,GO:0000405,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0097159,GO:1901363											Escherichia	1REYJ@1224,1S4XF@1236,2999H@1,2ZWCQ@2,3XQP7@561	NA|NA|NA	S	bubble DNA binding
b0548	316407.85674683	1.2e-24	118.2	Gammaproteobacteria													Escherichia	1N848@1224,1SDC4@1236,2E83F@1,332HC@2	NA|NA|NA		
b0549	316407.85674684	4.9e-50	203.4	Gammaproteobacteria													Escherichia	1N2ZM@1224,1S9DB@1236,2D7I9@1,32TP3@2	NA|NA|NA	S	phage protein
b0550	199310.c1557	7.4e-64	249.6	Escherichia	rusA	GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008821,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.1.22.4	ko:K01160					ko00000,ko01000,ko03400				Escherichia	1N92D@1224,1SDZ5@1236,3XPWD@561,COG4570@1,COG4570@2	NA|NA|NA	L	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of
b0551	316407.85674687	2.1e-69	268.1	Escherichia	ybcQ	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008150,GO:0009987,GO:0042710,GO:0044010,GO:0044764,GO:0051704,GO:0097159,GO:1901363											Escherichia	1RFJS@1224,1S64B@1236,2CAXP@1,2ZQA6@2,3XQ4Q@561	NA|NA|NA	K	Antitermination protein Q homolog from lambdoid prophage DLP12
b0552	316407.1736552	5.6e-194	683.3	Gammaproteobacteria													Escherichia	1MVDK@1224,1RR0T@1236,COG3039@1,COG3039@2	NA|NA|NA	L	COG3039 Transposase and inactivated derivatives IS5 family
b0554	199310.c1561	6.8e-33	146.0	Escherichia	essD	GO:0001906,GO:0001907,GO:0008150,GO:0016032,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192											Escherichia	1NAY0@1224,1SFBJ@1236,2E3SS@1,32YQ9@2,3XQ2B@561	NA|NA|NA	S	Lysis protein S homolog from lambdoid prophage
b0555	316407.85674690	3.4e-91	340.9	Escherichia	rrrD	GO:0001906,GO:0001907,GO:0003674,GO:0003796,GO:0003824,GO:0004553,GO:0008150,GO:0016032,GO:0016787,GO:0016798,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192,GO:0061783	3.2.1.17	ko:K01185					ko00000,ko01000				Escherichia	1MZJD@1224,1S6BA@1236,3XPV0@561,COG3772@1,COG3772@2	NA|NA|NA	G	Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Exhibits lytic activity against E.coli and S.typhi cell wall substrate
b0556	316407.85674691	2.6e-74	284.6	Escherichia	rzpD			ko:K14744					ko00000,ko01000				Escherichia	1N10F@1224,1S95X@1236,2DP4N@1,330HV@2,3XPIW@561	NA|NA|NA	S	Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the murein component of the bacterial cell wall (By similarity)
b4510	10710.SPAN2_LAMBD	1.1e-15	88.6	Siphoviridae													Escherichia	4QF9F@10239,4QMD5@10699,4QQYT@28883,4QW74@35237	NA|NA|NA	S	Lipoprotein Rz1 precursor
b0557	316407.85674693	5.1e-47	193.4	Gammaproteobacteria													Escherichia	1N1FA@1224,1S98N@1236,2CJNH@1,32U6W@2	NA|NA|NA	S	Bor protein
b0558	316407.85674694	1.9e-71	275.0	Bacteria													Escherichia	COG5562@1,COG5562@2	NA|NA|NA	E	phage envelope protein
b4589	511145.b4589	6.6e-27	125.9	Gammaproteobacteria													Escherichia	1NNEJ@1224,1SJ98@1236,2DR7X@1,33AKV@2	NA|NA|NA	S	Domain of unknown function (DUF3950)
b0560	316407.85674696	9.3e-95	352.8	Escherichia	nohD			ko:K22014					ko00000				Escherichia	1RFQ1@1224,1S33Z@1236,3XQB6@561,COG4220@1,COG4220@2	NA|NA|NA	L	DNA packaging
b4634	754331.AEME01000001_gene3079	1.5e-52	211.8	Escherichia	JD73_18725		3.1.21.4	ko:K21512					ko00000,ko01000				Escherichia	1MVS3@1224,1RRH5@1236,3XNU1@561,COG5525@1,COG5525@2	NA|NA|NA	S	Phage terminase large subunit (GpA)
b0561	502347.ESCAB7627_1227	3.8e-75	287.7	Escherichia	tfaQ												Escherichia	1MYT5@1224,1S7KD@1236,3XPJT@561,COG2110@1,COG2110@2	NA|NA|NA	S	Tail fiber assembly protein homolog from lambdoid prophage
b0563	199310.c1475	8.2e-27	125.6	Escherichia													Escherichia	1QWXM@1224,1T2YQ@1236,2DR39@1,339ZE@2,3XR44@561	NA|NA|NA	S	Caudovirales tail fibre assembly protein, lambda gpK
b0564	1440052.EAKF1_ch0901c	5.5e-138	496.9	Escherichia		GO:0003674,GO:0003700,GO:0006355,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009314,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010165,GO:0010212,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016036,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K07780	ko02020,map02020				ko00000,ko00001,ko03000				Escherichia	1Q19X@1224,1RPD4@1236,3XQUJ@561,COG2207@1,COG2207@2	NA|NA|NA	K	Helix-turn-helix domain
b0565	316407.85674700	6.5e-184	649.8	Escherichia	ompT	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009279,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0043170,GO:0044238,GO:0044425,GO:0044462,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.23.49	ko:K01355					ko00000,ko01000,ko01002				Escherichia	1MWE3@1224,1RRNQ@1236,3XN2E@561,COG4571@1,COG4571@2	NA|NA|NA	M	Protease that can cleave T7 RNA polymerase, ferric enterobactin receptor protein (FEP), antimicrobial peptide protamine and other proteins. This protease has a specificity for paired basic residues
b0566	316407.1651235	3.3e-138	497.7	Escherichia	envY	GO:0003674,GO:0003700,GO:0005575,GO:0006355,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141		ko:K11920					ko00000,ko03000				Escherichia	1R8WH@1224,1S13W@1236,3XQQ2@561,COG2207@1,COG2207@2	NA|NA|NA	K	Porin thermoregulatory protein EnvY
b0567	316407.4062193	2.3e-167	594.7	Escherichia	ybcH												Escherichia	1NVNA@1224,1S1MI@1236,2DBCW@1,2Z8FS@2,3XNQX@561	NA|NA|NA	S	Domain of unknown function (DUF4434)
b0568	316407.1651236	0.0	1976.8	Escherichia	nfrA	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K11739					ko00000				Escherichia	1N6EA@1224,1T2BB@1236,3XPEU@561,COG4783@1,COG4783@2	NA|NA|NA	M	Bacteriophage N4 adsorption protein A
b0569	155864.EDL933_0625	0.0	1480.7	Escherichia	nfrB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K11740					ko00000				Escherichia	1P7GR@1224,1RNP2@1236,3XNQZ@561,COG1215@1,COG1215@2	NA|NA|NA	M	Bacteriophage N4 adsorption protein B
b0570	316407.85674701	7.6e-269	932.6	Escherichia	cusS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046688,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071280,GO:0071292,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07644	ko02020,map02020	M00452,M00745			ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022				Escherichia	1QTV1@1224,1T1I6@1236,3XPE1@561,COG5002@1,COG5002@2	NA|NA|NA	T	Member of the two-component regulatory system CusS CusR. Copper ion sensor. Could also be a silver ion sensor. Activates CusR by phosphorylation
b0571	155864.EDL933_0634	3.5e-123	447.6	Escherichia	cusR	GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K07665	ko02020,map02020	M00452,M00745			ko00000,ko00001,ko00002,ko01504,ko02022				Escherichia	1MU67@1224,1RNWH@1236,3XM99@561,COG0745@1,COG0745@2	NA|NA|NA	K	Member of the two-component regulatory system CusS CusR. Activates the expression of cusCFBA
b0572	316407.4062196	1.6e-247	861.7	Escherichia	cusC	GO:0000041,GO:0003674,GO:0005215,GO:0005375,GO:0005488,GO:0005507,GO:0006464,GO:0006497,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006873,GO:0006875,GO:0006878,GO:0006950,GO:0008150,GO:0008152,GO:0008289,GO:0008324,GO:0009058,GO:0009059,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015318,GO:0016043,GO:0018345,GO:0019538,GO:0019725,GO:0019992,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034645,GO:0035434,GO:0036211,GO:0042157,GO:0042158,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046688,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0060003,GO:0061687,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0098771,GO:1901564,GO:1901566,GO:1901576,GO:1990169		ko:K07796	ko02020,map02020				ko00000,ko00001,ko02000	1.B.17.3.4,1.B.17.3.5		iAPECO1_1312.APECO1_1476,iECOK1_1307.ECOK1_0581,iECS88_1305.ECS88_0609,iSFxv_1172.SFxv_0521,iS_1188.S0481,iUMN146_1321.UM146_14655,iUTI89_1310.UTI89_C0572	Escherichia	1MUA8@1224,1RMDA@1236,3XNE7@561,COG1538@1,COG1538@2	NA|NA|NA	M	Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver
b0573	316407.4062197	5.7e-55	219.9	Escherichia	cusF	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0006873,GO:0006875,GO:0006878,GO:0006950,GO:0008150,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010272,GO:0010273,GO:0016530,GO:0016531,GO:0019725,GO:0030003,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042592,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046688,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0061687,GO:0065007,GO:0065008,GO:0097501,GO:0098754,GO:0098771,GO:0140104,GO:1990169		ko:K07810	ko02020,map02020				ko00000,ko00001	2.A.6.1.4		iAF1260.b0573,iAPECO1_1312.APECO1_1475,iBWG_1329.BWG_0444,iE2348C_1286.E2348C_0473,iEC042_1314.EC042_0607,iECABU_c1320.ECABU_c06220,iECDH10B_1368.ECDH10B_0531,iECDH1ME8569_1439.ECDH1ME8569_0541,iECED1_1282.ECED1_0565,iECIAI39_1322.ECIAI39_0548,iECNA114_1301.ECNA114_0504,iECOK1_1307.ECOK1_0582,iECP_1309.ECP_0604,iECS88_1305.ECS88_0610,iECSF_1327.ECSF_0503,iETEC_1333.ETEC_0601,iEcDH1_1363.EcDH1_3056,iEcHS_1320.EcHS_A0620,iEcolC_1368.EcolC_3073,iJO1366.b0573,iLF82_1304.LF82_0388,iNRG857_1313.NRG857_02575,iSFV_1184.SFV_0506,iSF_1195.SF0474,iSFxv_1172.SFxv_0522,iS_1188.S0482,iUMN146_1321.UM146_14650,iUMNK88_1353.UMNK88_602,iUTI89_1310.UTI89_C0573,iY75_1357.Y75_RS02975,ic_1306.c0659	Escherichia	1N4KG@1224,1S9YP@1236,3XQZW@561,COG5569@1,COG5569@2	NA|NA|NA	S	Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide
b0574	316407.4062198	2.3e-226	791.2	Escherichia	cusB	GO:0000041,GO:0003674,GO:0005215,GO:0005375,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006873,GO:0006875,GO:0006878,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015318,GO:0015679,GO:0019725,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030288,GO:0030313,GO:0031975,GO:0034220,GO:0035434,GO:0042221,GO:0042592,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046688,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0060003,GO:0061687,GO:0065007,GO:0065008,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0098771,GO:1990169		ko:K07798	ko02020,map02020				ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1		iECSF_1327.ECSF_0504	Escherichia	1MVAS@1224,1RPBZ@1236,3XP54@561,COG0845@1,COG0845@2	NA|NA|NA	M	Part of a cation efflux system that mediates resistance to copper and silver
b0575	316407.4062205	0.0	2017.3	Escherichia	cusA	GO:0000041,GO:0003674,GO:0005215,GO:0005375,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006873,GO:0006875,GO:0006878,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015080,GO:0015318,GO:0015673,GO:0015679,GO:0016020,GO:0016021,GO:0019725,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0031224,GO:0034220,GO:0035434,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044464,GO:0046688,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0060003,GO:0061687,GO:0065007,GO:0065008,GO:0071944,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0098771,GO:1902601,GO:1990169		ko:K07787	ko02020,map02020				ko00000,ko00001,ko02000	2.A.6.1.4		iB21_1397.B21_00525,iECBD_1354.ECBD_3087,iECB_1328.ECB_00536,iECD_1391.ECD_00536	Escherichia	1NUIV@1224,1SP6I@1236,3XP8C@561,COG3696@1,COG3696@2	NA|NA|NA	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
b0576	316407.1651239	1.1e-253	882.1	Escherichia	pheP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K11732					ko00000,ko02000	2.A.3.1.1		iAPECO1_1312.APECO1_1472,iECW_1372.ECW_m0628,iEcolC_1368.EcolC_3070,iUTI89_1310.UTI89_C0576,iWFL_1372.ECW_m0628	Escherichia	1MUPS@1224,1RNK0@1236,3XQGC@561,COG1113@1,COG1113@2	NA|NA|NA	P	Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine
b0577	198214.SF0483	5.6e-228	796.6	Gammaproteobacteria													Escherichia	1MVX9@1224,1RNBM@1236,COG0668@1,COG0668@2	NA|NA|NA	M	Mechanosensitive Ion channel
b0578	316407.1651240	1.9e-118	431.8	Escherichia	nfnB	GO:0000166,GO:0003674,GO:0003824,GO:0004155,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010181,GO:0016491,GO:0016645,GO:0016646,GO:0016651,GO:0016657,GO:0018545,GO:0018973,GO:0018974,GO:0019326,GO:0019439,GO:0032553,GO:0036094,GO:0042537,GO:0042802,GO:0043167,GO:0043168,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046256,GO:0046260,GO:0046263,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072490,GO:0072491,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	1.5.1.34	ko:K10679	ko00633,ko01120,map00633,map01120		R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000			iECUMN_1333.ECUMN_0668,iEcSMS35_1347.EcSMS35_0596	Escherichia	1N95W@1224,1RSDH@1236,3XN05@561,COG0778@1,COG0778@2	NA|NA|NA	C	Oxygen-insensitive NAD(P)H nitroreductase
b0579	155864.EDL933_0643	9.5e-67	259.2	Escherichia	ybdF												Escherichia	1RF0B@1224,1S4W1@1236,3XQZ7@561,COG2315@1,COG2315@2	NA|NA|NA	S	YjbR
b0580	316407.4062208	9.9e-36	155.6	Escherichia	ybdJ												Escherichia	1N36C@1224,1SA9U@1236,2DY8N@1,32V4Y@2,3XQ02@561	NA|NA|NA	S	Protein of unknown function (DUF1158)
b0581	316407.4062209	4.1e-222	776.9	Escherichia	ybdK	GO:0003674,GO:0003824,GO:0016874,GO:0016879		ko:K06048					ko00000,ko01000				Escherichia	1MX4N@1224,1RRZ1@1236,3XN9Q@561,COG2170@1,COG2170@2	NA|NA|NA	F	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
b4415	316407.85674703	5.7e-18	95.9	Gammaproteobacteria													Escherichia	1NER2@1224,1SD5D@1236,2ECM3@1,336J3@2	NA|NA|NA	S	Hok/gef family
b0582	203275.BFO_0831	1.2e-210	738.8	Bacteria													Escherichia	COG3385@1,COG3385@2	NA|NA|NA	L	transposase activity
b0583	316407.85674704	2.9e-116	424.5	Escherichia	entD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008897,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009366,GO:0009712,GO:0009713,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	6.3.2.14	ko:K02362	ko01053,ko01110,ko01130,map01053,map01110,map01130		R07644	RC00162,RC03046	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1466,iECO111_1330.ECO111_0612,iEcE24377_1341.EcE24377A_0601,iSSON_1240.SSON_0533,iUTI89_1310.UTI89_C0583	Escherichia	1MZK2@1224,1S968@1236,3XNT7@561,COG2977@1,COG2977@2	NA|NA|NA	H	Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2 ) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'- phosphopantetheine (Ppant) moiety from coenzyme A to the apo- domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively
b0584	316407.4062212	0.0	1528.1	Escherichia	fepA	GO:0000041,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0006855,GO:0006873,GO:0006875,GO:0006879,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009279,GO:0009987,GO:0015031,GO:0015238,GO:0015267,GO:0015343,GO:0015399,GO:0015405,GO:0015450,GO:0015620,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015833,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019725,GO:0019867,GO:0019904,GO:0022803,GO:0022804,GO:0022834,GO:0022836,GO:0022857,GO:0022884,GO:0022885,GO:0030001,GO:0030003,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0033036,GO:0033212,GO:0033214,GO:0042221,GO:0042493,GO:0042592,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042912,GO:0042914,GO:0042930,GO:0043213,GO:0044425,GO:0044462,GO:0044464,GO:0044718,GO:0045184,GO:0045203,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0072512,GO:0098771,GO:1901678,GO:1904680		ko:K19611	ko02020,map02020				ko00000,ko00001,ko02000	1.B.14.1.22,1.B.14.1.3,1.B.14.1.5		iECABU_c1320.ECABU_c06330,iECP_1309.ECP_0615,iLF82_1304.LF82_0640,iNRG857_1313.NRG857_02640,iSDY_1059.SDY_0512	Escherichia	1MUC1@1224,1RNHR@1236,3XNAQ@561,COG1629@1,COG4771@2	NA|NA|NA	P	This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D
b0585	481805.EcolC_3060	4.4e-246	856.7	Escherichia	fes	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0008150,GO:0008152,GO:0008849,GO:0009056,GO:0009237,GO:0009238,GO:0009712,GO:0009987,GO:0016787,GO:0016788,GO:0018958,GO:0019336,GO:0019439,GO:0019614,GO:0019748,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046214,GO:0046215,GO:0046483,GO:0046700,GO:0051186,GO:0051187,GO:0071704,GO:0090487,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616		ko:K07214					ko00000			iECNA114_1301.ECNA114_0527,iSbBS512_1146.SbBS512_E0486	Escherichia	1MXJN@1224,1RPMW@1236,3XM5Q@561,COG2382@1,COG2382@2	NA|NA|NA	P	esterase
b4511	316407.85674706	1.6e-37	161.4	Escherichia	ybdZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N87J@1224,1SCB8@1236,3XQ0B@561,COG3251@1,COG3251@2	NA|NA|NA	S	Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. Plays a role in the catalytic function of EntF. It is required for adenylation of amino acids in non-ribosomal peptide biosynthesis
b0586	316407.85674707	0.0	2585.1	Escherichia	entF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009366,GO:0009712,GO:0009713,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0019752,GO:0019842,GO:0031177,GO:0032991,GO:0033218,GO:0034641,GO:0036094,GO:0043038,GO:0043041,GO:0043043,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0047527,GO:0048037,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072341,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	6.3.2.14	ko:K02364	ko01053,ko01110,ko01130,map01053,map01110,map01130		R07644	RC00162,RC03046	ko00000,ko00001,ko01000,ko01008			iECO111_1330.ECO111_0616,iECO26_1355.ECO26_0661,iECSE_1348.ECSE_0653,iEcolC_1368.EcolC_3058	Escherichia	1QK4F@1224,1RPAG@1236,3XMWV@561,COG1020@1,COG1020@2,COG3319@1,COG3319@2	NA|NA|NA	Q	Activates the carboxylate group of L-serine via ATP- dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3- dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE)
b0587	316407.85674708	6.1e-205	719.9	Escherichia	fepE	GO:0000041,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0008150,GO:0015343,GO:0015620,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0016020,GO:0022857,GO:0030001,GO:0042930,GO:0044464,GO:0044718,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0072512,GO:1901678											Escherichia	1N0EC@1224,1RR0I@1236,3XMWK@561,COG3765@1,COG3765@2	NA|NA|NA	M	Ferric enterobactin transport protein FepE
b0588	316407.85674709	1.9e-152	545.0	Escherichia	fepC	GO:0000041,GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0008144,GO:0008150,GO:0015343,GO:0015620,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0016020,GO:0017076,GO:0022857,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042930,GO:0043167,GO:0043168,GO:0044464,GO:0044718,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0072512,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678	3.6.3.34	ko:K02013	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14		iAF1260.b0588,iB21_1397.B21_00544,iBWG_1329.BWG_0461,iE2348C_1286.E2348C_0490,iEC55989_1330.EC55989_0580,iECABU_c1320.ECABU_c06380,iECBD_1354.ECBD_3067,iECB_1328.ECB_00555,iECDH10B_1368.ECDH10B_0548,iECDH1ME8569_1439.ECDH1ME8569_0558,iECDH1ME8569_1439.EcDH1_3038,iECD_1391.ECD_00555,iECED1_1282.ECED1_0585,iECIAI1_1343.ECIAI1_0572,iECNA114_1301.ECNA114_0531,iECO103_1326.ECO103_0596,iECOK1_1307.ECOK1_0599,iECP_1309.ECP_0620,iECS88_1305.ECS88_0627,iECSE_1348.ECSE_0655,iECSF_1327.ECSF_0529,iECUMN_1333.ECUMN_0682,iECW_1372.ECW_m0643,iEKO11_1354.EKO11_3277,iETEC_1333.ETEC_0618,iEcDH1_1363.EcDH1_3038,iEcE24377_1341.EcE24377A_0607,iEcHS_1320.EcHS_A0639,iEcolC_1368.EcolC_3056,iJO1366.b0588,iLF82_1304.LF82_0642,iNRG857_1313.NRG857_02665,iSDY_1059.SDY_0519,iSFV_1184.SFV_0536,iUMN146_1321.UM146_14565,iUMNK88_1353.UMNK88_620,iUTI89_1310.UTI89_C0590,iWFL_1372.ECW_m0643,iY75_1357.Y75_RS03065,ic_1306.c0675	Escherichia	1MUNG@1224,1RRII@1236,3XMZN@561,COG1120@1,COG1120@2	NA|NA|NA	P	Probably responsible for energy coupling to the transport system
b0589	316407.85674710	4.1e-165	587.4	Escherichia	fepG	GO:0000041,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0008150,GO:0015343,GO:0015620,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0016020,GO:0022857,GO:0030001,GO:0042930,GO:0044464,GO:0044718,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0072512,GO:1901678		ko:K02015	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14		iAPECO1_1312.APECO1_1460,iEC55989_1330.EC55989_0581,iECABU_c1320.ECABU_c06390,iECED1_1282.ECED1_0586,iECOK1_1307.ECOK1_0601,iECP_1309.ECP_0621,iECS88_1305.ECS88_0628,iEcE24377_1341.EcE24377A_0609,iLF82_1304.LF82_0645,iNRG857_1313.NRG857_02670,iSBO_1134.SBO_0450,iSbBS512_1146.SbBS512_E0491,ic_1306.c0676	Escherichia	1NXD0@1224,1RS0J@1236,3XPG4@561,COG4779@1,COG4779@2	NA|NA|NA	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
b0590	316407.85674711	1.8e-168	598.6	Escherichia	fepD	GO:0000041,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0008150,GO:0015343,GO:0015620,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0016020,GO:0022857,GO:0030001,GO:0042930,GO:0044464,GO:0044718,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0072512,GO:1901678		ko:K02015	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14		iECH74115_1262.ECH74115_0675,iECO103_1326.ECO103_0598,iECSP_1301.ECSP_0644,iECUMN_1333.ECUMN_0684,iECs_1301.ECs0629,iEcHS_1320.EcHS_A0641,iG2583_1286.G2583_0753,iSBO_1134.SBO_0451,iSFV_1184.SFV_0538,iSbBS512_1146.SbBS512_E0492,iZ_1308.Z0732	Escherichia	1MYYG@1224,1RRQ1@1236,3XPEY@561,COG0609@1,COG0609@2	NA|NA|NA	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
b0591	316407.85674712	9.6e-212	742.7	Escherichia	entS	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0016020,GO:0033554,GO:0042221,GO:0042930,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0051716,GO:0071702,GO:0071944,GO:1901678		ko:K08225					ko00000,ko02000	2.A.1.38		iECABU_c1320.ECABU_c06410,iSBO_1134.SBO_0452	Escherichia	1MXZ3@1224,1RMY2@1236,3XN2P@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Exports the siderophore enterobactin out of the cell
b0592	199310.c0679	2.8e-171	607.8	Escherichia	fepB	GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0030001,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0042930,GO:0044464,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0051716,GO:0071702,GO:0072512,GO:1901678		ko:K02016	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14		iECNA114_1301.ECNA114_0535	Escherichia	1NPCN@1224,1RPS9@1236,3XNYB@561,COG4592@1,COG4592@2	NA|NA|NA	P	part of the binding-protein- dependent transport system for uptake of ferrienterobactin
b0593	155864.EDL933_0663	1.1e-220	772.3	Escherichia	entC	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008909,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016853,GO:0016866,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0034641,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044550,GO:0046189,GO:0046483,GO:0046872,GO:0050486,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	5.4.4.2	ko:K02361	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_0585,iECIAI1_1343.ECIAI1_0577,iECO103_1326.ECO103_0601,iECO111_1330.ECO111_0623,iECO26_1355.ECO26_0668,iECW_1372.ECW_m0648,iEKO11_1354.EKO11_3272,iEcE24377_1341.EcE24377A_0613,iSbBS512_1146.SbBS512_E0495,iUMNK88_1353.UMNK88_626,iWFL_1372.ECW_m0648	Escherichia	1MVB7@1224,1RRBX@1236,3XNJD@561,COG1169@1,COG1169@2	NA|NA|NA	HQ	Involved in the biosynthesis of the siderophore enterobactin (macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine). Catalyzes the reversible conversion of chorismate to isochorismate
b0594	316407.85674715	2.7e-310	1070.5	Escherichia	entE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008668,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0034641,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0047527,GO:0051186,GO:0051188,GO:0070566,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.7.7.58,6.3.2.14	ko:K02363	ko01053,ko01110,ko01130,map01053,map01110,map01130		R07644	RC00162,RC03046	ko00000,ko00001,ko01000,ko01008			iSF_1195.SF0508,iSSON_1240.SSON_0545,iS_1188.S0514,iZ_1308.Z0736	Escherichia	1NSN8@1224,1RP8K@1236,3XMDK@561,COG1021@1,COG1021@2	NA|NA|NA	Q	Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2 ) atoms. EntE proccesses via a two-step adenylation- ligation reaction (bi-uni-uni-bi ping-pong mechanism). First, it catalyzes the activation of the carboxylate group of 2,3- dihydroxy-benzoate (DHB), via a reversible ATP-dependent pyrophosphate exchange reactions to yield the acyladenylate intermediate 2,3-dihydroxybenzoyl-AMP. It can also transfer AMP to salicylate, 2,4-dihydroxybenzoate, gentisate and 2,3,4- trihydroxybenzoate. In the second step, DHB is transferred from 2,3-dihydroxybenzoyl-AMP onto the phosphopantetheinylated EntB (holo-EntB) to form DHB-holo-EntB. Then this product will serve in the formation of the amide bond between 2,3-dihydroxybenzoate (DHB) and L-serine
b0595	155864.EDL933_0665	1.9e-166	591.7	Escherichia	entB	GO:0000287,GO:0003674,GO:0003824,GO:0004463,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008908,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0016787,GO:0016801,GO:0016803,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0019842,GO:0031177,GO:0033218,GO:0034641,GO:0036094,GO:0042802,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0046872,GO:0047527,GO:0048037,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072341,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.3.2.1,6.3.2.14	ko:K01252	ko01053,ko01110,ko01130,map01053,map01110,map01130		R03037,R07644	RC00162,RC00350,RC02148,RC03046	ko00000,ko00001,ko01000,ko01008			iSFV_1184.SFV_0543	Escherichia	1MW2U@1224,1RRZ8@1236,3XM33@561,COG1535@1,COG1535@2,COG3433@1,COG3433@2	NA|NA|NA	Q	Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2 ) atoms. EntB is a bifunctional protein that serves as an isochorismate lyase and an aryl carrier protein (ArCP). Catalyzes the conversion of isochorismate to 2,3-dihydro-2,3- dihydroxybenzoate (2,3-diDHB), the precursor of 2,3- dihydroxybenzoate (DHB). In the enterobactin assembly, EntB functions as an aryl carrier protein phosphopantetheinylated near the C terminus by EntD to yield holo-EntB, which is then acylated by EntE with 2,3-dihydroxybenzoyl-AMP to form DHB-holo-EntB. Then this product will serve in the formation of the amide bond between 2,3-dihydroxybenzoate (DHB) and L-serine
b0596	316407.85674717	2.3e-128	464.9	Escherichia	entA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.3.1.28	ko:K00216	ko01053,ko01110,ko01130,map01053,map01110,map01130		R01505	RC00534	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_0539,iECSF_1327.ECSF_0537,iSF_1195.SF0510,iSFxv_1172.SFxv_0563,iS_1188.S0516	Escherichia	1MUD2@1224,1RN5N@1236,3XMUU@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. Catalyzes the reversible NAD-dependent oxidation of the C3-hydroxyl group of 2,3-dihydro-2,3-dihydroxybenzoate (2,3-diDHB), producing the transient intermediate 2-hydroxy-3-oxo-4,6-cyclohexadiene-1- carboxylate, which undergoes rapid aromatization to the final product, 2,3-dihydroxybenzoate (2,3-DHB). Only the compounds with a C3-hydroxyl group such as methyl 2,3-dihydro-2,3- dihydroxybenzoate, methyl-3-hydroxy-1,4-cyclohexadiene-1- carboxylate, trans-3-hydroxy-2-cyclohexene-1-carboxylate, cis-3- hydroxy-4-cyclohexene-1-carboxylate, cis-3-hydroxycyclohexane-1- carboxylic acid are oxidized to the corresponding ketone products. The stereospecificity of the C3 allylic alcohol group oxidation is 3R in a 1R,3R dihydro substrate. It can also increase the DHB-AMP ligase activity of EntE by interaction EntE
b0597	199310.c0684	5.6e-76	290.0	Escherichia	entH	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617											Escherichia	1MYE0@1224,1S2CT@1236,3XPMR@561,COG2050@1,COG2050@2	NA|NA|NA	Q	Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules
b0598	316407.85674719	0.0	1307.4	Escherichia	cstA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944		ko:K06200					ko00000				Escherichia	1MWF9@1224,1RMG4@1236,3XM2Y@561,COG1966@1,COG1966@2	NA|NA|NA	T	carbon starvation protein
b4512	155864.EDL933_0670	5.3e-32	142.9	Escherichia	ybdD												Escherichia	1N6TY@1224,1S8ZU@1236,3XPZM@561,COG2879@1,COG2879@2	NA|NA|NA	S	Selenoprotein, putative
b0599	316407.4062216	5.3e-206	723.4	Escherichia	ybdH	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0042802,GO:0047545,GO:0055114		ko:K08317					ko00000,ko01000				Escherichia	1MWAE@1224,1RM83@1236,3XP6W@561,COG0371@1,COG0371@2	NA|NA|NA	C	Catalyzes the NADPH-dependent reduction of 2- oxoglutarate and 2-oxobutanoate, leading to the respective 2- hydroxycarboxylate. Cannot use NADH instead of NADPH as a redox partner. Do not catalyze the reverse reactions
b0600	316407.4062217	3.5e-224	783.9	Escherichia	ybdL	GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.88	ko:K14287			R08618	RC00006,RC00025	ko00000,ko01000,ko01007				Escherichia	1MW0Z@1224,1RNN0@1236,3XM9Q@561,COG0436@1,COG0436@2	NA|NA|NA	E	Aminotransferase
b0601	316407.85674720	3.8e-116	424.1	Escherichia	ybdM												Escherichia	1R5VN@1224,1RZ7C@1236,3XNY5@561,COG1475@1,COG1475@2	NA|NA|NA	K	ParB-like nuclease domain
b0602	316407.4062219	4.5e-254	883.2	Escherichia	ybdN												Escherichia	1NBDM@1224,1RYRP@1236,3XNM6@561,COG3969@1,COG3969@2	NA|NA|NA	S	catalytic activity
b0603	316407.4062220	1.2e-163	582.4	Escherichia	ybdO	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141											Escherichia	1QD8R@1224,1RSHD@1236,3XNPV@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
b0604	316407.85674721	2.6e-140	504.6	Escherichia	dsbG	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0042597,GO:0044464,GO:0055114,GO:0140096		ko:K03805					ko00000,ko03110			iECO111_1330.ECO111_0636,iECO26_1355.ECO26_0680,iEcE24377_1341.EcE24377A_0625,iG2583_1286.G2583_0768	Escherichia	1NEFD@1224,1RQAW@1236,3XNA2@561,COG1651@1,COG1651@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
b0605	155864.EDL933_0677	1.3e-104	385.6	Escherichia	ahpC	GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009321,GO:0009605,GO:0009636,GO:0009970,GO:0009987,GO:0009991,GO:0010033,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0019725,GO:0030003,GO:0031667,GO:0031668,GO:0031669,GO:0032843,GO:0032991,GO:0033194,GO:0033195,GO:0033212,GO:0033214,GO:0033554,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071496,GO:0097237,GO:0098754,GO:0098771,GO:0098869,GO:1901700,GO:1902494,GO:1990204,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214				ko00000,ko00001,ko01000,ko04147				Escherichia	1MWPY@1224,1RN4S@1236,3XM46@561,COG0450@1,COG0450@2	NA|NA|NA	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
b0606	155864.EDL933_0678	6.5e-298	1029.2	Escherichia	ahpF	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008785,GO:0009321,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1902494,GO:1990204		ko:K03387					ko00000,ko01000				Escherichia	1MUKD@1224,1RNC7@1236,3XPHP@561,COG3634@1,COG3634@2	NA|NA|NA	O	Alkyl hydroperoxide reductase
b0607	316407.4062223	3.9e-72	277.3	Escherichia	uspG	GO:0003674,GO:0003824,GO:0004017,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018117,GO:0018130,GO:0018175,GO:0019205,GO:0019438,GO:0019538,GO:0019637,GO:0032879,GO:0034641,GO:0034654,GO:0036211,GO:0040012,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046777,GO:0046940,GO:0050145,GO:0050789,GO:0050794,GO:0051270,GO:0055086,GO:0065007,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:2000145		ko:K11932					ko00000				Escherichia	1RA7K@1224,1S2PE@1236,3XPN8@561,COG0589@1,COG0589@2	NA|NA|NA	T	Belongs to the universal stress protein A family
b0608	316407.4062224	2.2e-240	837.8	Escherichia	ybdR												Escherichia	1MW6Y@1224,1RRPT@1236,3XP75@561,COG1063@1,COG1063@2	NA|NA|NA	E	zinc ion binding
b0610	155864.EDL933_0683	1.6e-70	271.9	Escherichia	rnk			ko:K06140					ko00000,ko03000				Escherichia	1MZNY@1224,1S8V4@1236,3XPJU@561,COG0782@1,COG0782@2	NA|NA|NA	K	May act as an anti-Gre factor
b0611	316407.1651249	8.2e-156	556.2	Escherichia	rna	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0019439,GO:0030288,GO:0030313,GO:0031975,GO:0034641,GO:0034655,GO:0042597,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	3.1.27.6	ko:K01169					ko00000,ko01000,ko03016				Escherichia	1NRPM@1224,1RND8@1236,3XMFW@561,COG3719@1,COG3719@2	NA|NA|NA	J	Belongs to the RNase T2 family
b0612	316407.4062225	8.5e-276	955.7	Escherichia	citT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K09477	ko02020,map02020				ko00000,ko00001,ko02000	2.A.47.3.2		iSSON_1240.SSON_0564	Escherichia	1MUSA@1224,1RMF3@1236,3XM3A@561,COG0471@1,COG0471@2	NA|NA|NA	P	Responsible for the uptake of citrate in exchange with the efflux of succinate, fumarate or tartrate. Has a relatively broad specificity for C(4)-dicarboxylates and tricarboxylates
b0613	316407.85674722	5.6e-166	590.1	Escherichia	citG	GO:0003674,GO:0003824,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019538,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046917,GO:0051186,GO:0051188,GO:0051189,GO:0051191,GO:0071704,GO:1901564,GO:1901576	2.4.2.52	ko:K05966	ko02020,map02020		R09675	RC00049,RC00063	ko00000,ko00001,ko01000			iECSF_1327.ECSF_0553	Escherichia	1N9IK@1224,1RYW6@1236,3XNS3@561,COG1767@1,COG1767@2	NA|NA|NA	F	Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA
b0614	155864.EDL933_0687	5.7e-100	370.2	Escherichia	citX	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018065,GO:0018193,GO:0018209,GO:0018246,GO:0018247,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050519,GO:0071704,GO:1901564	2.7.7.61	ko:K05964	ko02020,map02020		R10706		ko00000,ko00001,ko01000			iEcHS_1320.EcHS_A0665,iEcolC_1368.EcolC_3030	Escherichia	1RDJS@1224,1S4KU@1236,3XMCM@561,COG3697@1,COG3697@2	NA|NA|NA	H	Transfers 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein
b0615	316407.85674724	7e-289	999.2	Escherichia	citF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.8.3.10	ko:K01643	ko02020,map02020		R00362	RC00067,RC01118	ko00000,ko00001,ko01000			iEcSMS35_1347.EcSMS35_0634	Escherichia	1MYI9@1224,1RQ32@1236,3XNRW@561,COG3051@1,COG3051@2	NA|NA|NA	C	Citrate (pro-3S)-lyase alpha chain
b0616	199310.c0706	2.7e-163	581.3	Escherichia	citE	GO:0000287,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046872,GO:0071704	4.1.3.34	ko:K01644	ko02020,map02020		R00362	RC00067,RC01118	ko00000,ko00001,ko01000			iSFxv_1172.SFxv_0589	Escherichia	1MW0A@1224,1RNEJ@1236,3XNE8@561,COG2301@1,COG2301@2	NA|NA|NA	G	Belongs to the HpcH HpaI aldolase family
b0617	155864.EDL933_0690	6.1e-48	196.4	Escherichia	citD	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051192		ko:K01646	ko02020,map02020		R00362	RC00067,RC01118	ko00000,ko00001			iECABU_c1320.ECABU_c06690,iECED1_1282.ECED1_0614	Escherichia	1N20F@1224,1S98D@1236,3XPVK@561,COG3052@1,COG3052@2	NA|NA|NA	C	Covalent carrier of the coenzyme of citrate lyase
b0618	316407.85674725	2.9e-201	707.6	Escherichia	citC	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008771,GO:0009987,GO:0016874,GO:0016877,GO:0016878,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	6.2.1.22	ko:K01910	ko02020,map02020		R04449	RC00012,RC00039	ko00000,ko00001,ko01000				Escherichia	1NGEJ@1224,1RMMV@1236,3XNVE@561,COG3053@1,COG3053@2	NA|NA|NA	H	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
b0619	316407.4062236	9.2e-311	1072.0	Escherichia	citA	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010033,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07700	ko02020,map02020	M00486			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1MXQ5@1224,1RNRF@1236,3XPGZ@561,COG3290@1,COG3290@2	NA|NA|NA	T	Member of the two-component regulatory system DpiA DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions. Functions as a sensor kinase that phosphorylates DpiA in the presence of citrate
b0620	199310.c0711	6.3e-125	453.4	Escherichia	dpiA	GO:0000156,GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K07702	ko02020,map02020	M00486			ko00000,ko00001,ko00002,ko02022				Escherichia	1P6VJ@1224,1RPI7@1236,3XPEN@561,COG4565@1,COG4565@2	NA|NA|NA	K	Member of the two-component regulatory system DpiA DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions
b0621	155864.EDL933_0694	1.6e-236	825.1	Escherichia	dcuC	GO:0003674,GO:0005215,GO:0005310,GO:0005342,GO:0005469,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006067,GO:0006082,GO:0006083,GO:0006089,GO:0006090,GO:0006091,GO:0006103,GO:0006105,GO:0006113,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006855,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015075,GO:0015138,GO:0015141,GO:0015238,GO:0015291,GO:0015297,GO:0015318,GO:0015556,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015849,GO:0015893,GO:0015942,GO:0015980,GO:0016020,GO:0016021,GO:0016999,GO:0017144,GO:0019318,GO:0019362,GO:0019637,GO:0019660,GO:0019664,GO:0019666,GO:0019693,GO:0019752,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032787,GO:0034220,GO:0034308,GO:0034641,GO:0042221,GO:0042493,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046031,GO:0046034,GO:0046483,GO:0046496,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051186,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0071422,GO:0071702,GO:0071704,GO:0071944,GO:0072521,GO:0072524,GO:0098656,GO:1901135,GO:1901360,GO:1901564,GO:1901615,GO:1903825,GO:1905039		ko:K03326					ko00000,ko02000	2.A.61.1			Escherichia	1MWBG@1224,1RQB2@1236,3XNN1@561,COG3069@1,COG3069@2	NA|NA|NA	P	Responsible for the transport of C4-dicarboxylates during anaerobic growth
b0622	316407.85674727	6.6e-112	409.8	Escherichia	pagP	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009279,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016409,GO:0016416,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044462,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.251	ko:K12973	ko01503,ko05133,map01503,map05133	M00724	R11223	RC00037,RC00041	ko00000,ko00001,ko00002,ko01000,ko01005			iEC042_1314.EC042_0658,iECO111_1330.ECO111_0653,iECSE_1348.ECSE_0690,iEcolC_1368.EcolC_3022	Escherichia	1Q75P@1224,1RPCR@1236,2C256@1,2Z7SY@2,3XPJP@561	NA|NA|NA	M	Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors
b0623	1197719.A464_605	5.6e-32	142.9	Salmonella													Escherichia	1N6Q5@1224,1SCA7@1236,3ZMIG@590,COG1278@1,COG1278@2	NA|NA|NA	K	Ribonuclease B OB domain
b0624	316407.4062247	7.1e-65	253.1	Escherichia	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425		ko:K06199					ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3			Escherichia	1MZNH@1224,1S9GR@1236,3XPQE@561,COG0239@1,COG0239@2	NA|NA|NA	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
b4581	316407.4062248	4.1e-32	145.2	Escherichia	ybeM			ko:K11206					ko00000,ko01000				Escherichia	1MUUB@1224,1RNVZ@1236,3XMHF@561,COG0388@1,COG0388@2	NA|NA|NA	S	terminal fragment. The intact protein (AC A0A140NCB4) hydrolyzes deaminated glutathione (dGSH, 2-oxoglutaramate) to alpha- ketoglutarate (alpha-KG) and cysteinylglycine, has less activity against alpha-ketoglutaramate (a-KGM) and no activity on glutathione or L-glutamine (By similarity). May function as a metabolite repair enzyme (By similarity)
b0627	155864.EDL933_0699	7.6e-26	122.5	Escherichia	tatE			ko:K03425	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Escherichia	1N7JK@1224,1SCGF@1236,3XQ43@561,COG1826@1,COG1826@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA
b0628	155864.EDL933_0700	3.7e-187	660.6	Escherichia	lipA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100		R07767,R07768	RC01978	ko00000,ko00001,ko01000			iSbBS512_1146.SbBS512_E0542	Escherichia	1MVRD@1224,1RMAT@1236,3XP60@561,COG0320@1,COG0320@2	NA|NA|NA	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
b0629	316407.4062251	8.2e-179	632.9	Escherichia	ybeF	GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Escherichia	1Q6Q3@1224,1RV8G@1236,3XNG9@561,COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
b0630	155864.EDL933_0703	1.5e-120	438.7	Escherichia	lipB	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100		R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000			iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718	Escherichia	1MU6A@1224,1RMXQ@1236,3XM74@561,COG0321@1,COG0321@2	NA|NA|NA	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate
b0631	1440052.EAKF1_ch0831	3.7e-41	173.7	Escherichia	ybeD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09158					ko00000				Escherichia	1RGV5@1224,1S61Y@1236,3XPY6@561,COG2921@1,COG2921@2	NA|NA|NA	S	Belongs to the UPF0250 family
b0632	155864.EDL933_0705	2.4e-231	807.7	Escherichia	dacA	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044237,GO:0044238,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0071554,GO:0071704,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901363,GO:1901564,GO:1901681	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100				ko00000,ko00001,ko01000,ko01002,ko01011			iSFV_1184.SFV_0694	Escherichia	1MUU7@1224,1RMJA@1236,3XM3R@561,COG1686@1,COG1686@2	NA|NA|NA	M	Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
b0633	316407.1651260	7.7e-181	639.8	Escherichia	rlpA	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K03642					ko00000				Escherichia	1MZ8S@1224,1RMCG@1236,3XP5D@561,COG0797@1,COG0797@2	NA|NA|NA	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
b0634	155864.EDL933_0708	2.9e-199	701.0	Escherichia	mrdB	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0016020,GO:0022603,GO:0022604,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944		ko:K05837					ko00000,ko03036				Escherichia	1MUK3@1224,1RMEJ@1236,3XNZ0@561,COG0772@1,COG0772@2	NA|NA|NA	M	Peptidoglycan polymerase that is essential for cell wall elongation
b0635	155864.EDL933_0709	0.0	1283.9	Escherichia	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501				ko00000,ko00001,ko01000,ko01011			iEcE24377_1341.EcE24377A_0661	Escherichia	1MV8C@1224,1RN9H@1236,3XNHA@561,COG0768@1,COG0768@2	NA|NA|NA	M	Catalyzes cross-linking of the peptidoglycan cell wall
b0636	754331.AEME01000001_gene3902	6.8e-86	323.2	Escherichia	rlmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.177	ko:K00783					ko00000,ko01000,ko03009				Escherichia	1R9Z2@1224,1S1ZY@1236,3XNYW@561,COG1576@1,COG1576@2	NA|NA|NA	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
b0637	754331.AEME01000001_gene3903	7.4e-52	209.5	Escherichia	rsfS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113		ko:K09710					ko00000,ko03009				Escherichia	1MZEF@1224,1S8W3@1236,3XPWB@561,COG0799@1,COG0799@2	NA|NA|NA	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
b0638	316407.4062256	3.7e-116	424.1	Escherichia	cobC		3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1417,iEcSMS35_1347.EcSMS35_0658,iLF82_1304.LF82_0334,iUTI89_1310.UTI89_C0641	Escherichia	1RHAT@1224,1S2NY@1236,3XN3N@561,COG0406@1,COG0406@2	NA|NA|NA	G	Belongs to the phosphoglycerate mutase family
b0639	198214.SF0642	3.5e-125	454.1	Gammaproteobacteria													Escherichia	1RD0J@1224,1RP00@1236,COG1057@1,COG1057@2	NA|NA|NA	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
b0640	316407.1651267	1.6e-191	675.2	Escherichia	holA	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Escherichia	1MWYT@1224,1RQRE@1236,3XM3I@561,COG1466@1,COG1466@2	NA|NA|NA	L	Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3'-5' exonuclease activity. The delta subunit is the wrench that will open the beta subunit dimer, which has been modeled to leave a gap large enough for ssDNA to pass through. The gamma complex (gamma(3),delta,delta') is thought to load beta dimers onto DNA by binding ATP which alters the complex's conformation so it can bind beta sliding clamp dimers and open them at one interface. Primed DNA is recognized, ATP is hydrolyzed releasing the gamma complex and closing the beta sliding clamp ring around the primed DNA
b0641	199310.c0732	1.3e-99	369.0	Escherichia	lptE	GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264		ko:K03643					ko00000,ko02000	1.B.42.1		iECH74115_1262.ECH74115_0730,iECSP_1301.ECSP_0694,iECs_1301.ECs0679,iG2583_1286.G2583_0804,iZ_1308.Z0788	Escherichia	1N0JN@1224,1SAG4@1236,3XMTH@561,COG2980@1,COG2980@2	NA|NA|NA	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
b0642	316407.1651269	0.0	1776.1	Escherichia	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925	Escherichia	1MV47@1224,1RP14@1236,3XMA7@561,COG0495@1,COG0495@2	NA|NA|NA	J	Belongs to the class-I aminoacyl-tRNA synthetase family
b0643	155864.EDL933_0717	1.1e-86	325.9	Escherichia	ybeL												Escherichia	1P9T7@1224,1RYIB@1236,3XMF4@561,COG2888@1,COG2888@2	NA|NA|NA	J	Zinc-ribbon containing domain
b0645	316407.4062260	2.9e-141	507.7	Gammaproteobacteria													Escherichia	1R3BD@1224,1SIT7@1236,2DTDZ@1,33JXN@2	NA|NA|NA	S	Protein of unknown function (DUF1266)
b0646	316407.4062261	7.2e-272	942.6	Gammaproteobacteria													Escherichia	1ND28@1224,1RYBT@1236,COG2214@1,COG2214@2	NA|NA|NA	O	PFAM heat shock protein DnaJ domain protein
b0647	316407.4062262	1.4e-61	242.7	Escherichia	ybeT			ko:K07126					ko00000				Escherichia	1PE8S@1224,1RW8B@1236,3XPKY@561,COG0790@1,COG0790@2	NA|NA|NA	S	Sel1-like repeats.
b0648	316407.4062263	6.8e-138	496.5	Escherichia	ybeU												Escherichia	1RCBR@1224,1S2HD@1236,2DBZ5@1,2ZBZM@2,3XQJF@561	NA|NA|NA	S	Protein of unknown function (DUF1266)
b0649	316407.4062264	8.4e-284	982.2	Escherichia	djlC	GO:0001671,GO:0003674,GO:0008047,GO:0008150,GO:0030234,GO:0032781,GO:0043085,GO:0043462,GO:0044093,GO:0050790,GO:0051336,GO:0051345,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0098772											Escherichia	1ND28@1224,1SYVJ@1236,3XM84@561,COG2214@1,COG2214@2	NA|NA|NA	O	ATPase activator activity
b0650	316407.85674731	0.0	1090.1	Escherichia	hscC	GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111		ko:K04045					ko00000,ko03110	1.A.33		iSFV_1184.SFV_0676	Escherichia	1MUR1@1224,1RR7P@1236,3XM93@561,COG0443@1,COG0443@2	NA|NA|NA	O	heat shock protein 70
b0651	316407.4062271	5.2e-178	630.2	Escherichia	rihA	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045437,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0047405,GO:0050263,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658		ko:K01250					ko00000,ko01000			iEC55989_1330.EC55989_0645,iECSE_1348.ECSE_0721,iEcE24377_1341.EcE24377A_0679,iSbBS512_1146.SbBS512_E0598	Escherichia	1MUIW@1224,1RSCY@1236,3XN0M@561,COG1957@1,COG1957@2	NA|NA|NA	F	Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively
b0652	155864.EDL933_0729	4.1e-130	470.7	Escherichia	gltL	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K10004	ko02010,ko02020,map02010,map02020	M00230			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.19,3.A.1.3.4		iAPECO1_1312.APECO1_1411,iE2348C_1286.E2348C_0545,iECOK1_1307.ECOK1_0655,iECP_1309.ECP_0675,iECS88_1305.ECS88_0687,iEcSMS35_1347.EcSMS35_0673,iUMN146_1321.UM146_14290,iUTI89_1310.UTI89_C0648	Escherichia	1MU9Q@1224,1RMX1@1236,3XPF4@561,COG1126@1,COG1126@2	NA|NA|NA	P	Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for energy coupling to the transport system
b0653	155864.EDL933_0730	1.5e-113	415.6	Escherichia	gltK	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1901998,GO:1903825,GO:1905039		ko:K10002	ko02010,ko02020,map02010,map02020	M00230			ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4		iEcHS_1320.EcHS_A0698,iEcolC_1368.EcolC_2992,iSF_1195.SF0628,iSFxv_1172.SFxv_0695,iS_1188.S0650	Escherichia	1MV3I@1224,1RNX3@1236,3XN5D@561,COG0765@1,COG0765@2	NA|NA|NA	E	Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane
b0654	199310.c0738	5.6e-127	460.3	Escherichia	gltJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K10003	ko02010,ko02020,map02010,map02020	M00230			ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4			Escherichia	1MUVX@1224,1RMTK@1236,3XN5Z@561,COG0765@1,COG0765@2	NA|NA|NA	P	Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane
b0655	316407.85674732	9e-167	592.8	Escherichia	gltI	GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015813,GO:0015849,GO:0015893,GO:0016595,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070335,GO:0070778,GO:0071702,GO:0071705,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K10001	ko02010,ko02020,map02010,map02020	M00230			ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4		iECH74115_1262.ECH74115_0748,iECSE_1348.ECSE_0725,iECSP_1301.ECSP_0707,iECW_1372.ECW_m0710,iECs_1301.ECs0694,iEKO11_1354.EKO11_3211,iG2583_1286.G2583_0819,iSFV_1184.SFV_0671,iSF_1195.SF0626,iS_1188.S0648,iWFL_1372.ECW_m0710,iZ_1308.Z0805	Escherichia	1MV5D@1224,1RPBX@1236,3XM2X@561,COG0834@1,COG0834@2	NA|NA|NA	ET	Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Binds to both glutamate and aspartate
b0656	316407.1736552	5.6e-194	683.3	Gammaproteobacteria													Escherichia	1MVDK@1224,1RR0T@1236,COG3039@1,COG3039@2	NA|NA|NA	L	COG3039 Transposase and inactivated derivatives IS5 family
b0657	316407.85674734	5.7e-299	1032.7	Escherichia	lnt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0042157,GO:0042158,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576		ko:K03820					ko00000,ko01000		GT2	iSbBS512_1146.SbBS512_E0590	Escherichia	1MUBU@1224,1RM8M@1236,3XNIF@561,COG0815@1,COG0815@2	NA|NA|NA	M	Transfers the fatty acyl group on membrane lipoproteins
b0658	155864.EDL933_0735	1.6e-160	572.0	Escherichia	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K06189					ko00000,ko02000	9.A.40.1.2			Escherichia	1QTU8@1224,1RMKX@1236,3XN7E@561,COG4535@1,COG4535@2	NA|NA|NA	P	Magnesium and cobalt efflux protein CorC
b0659	198214.SF0623	1.4e-83	315.5	Gammaproteobacteria													Escherichia	1MZ67@1224,1S6BS@1236,COG0319@1,COG0319@2	NA|NA|NA	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
b0660	198214.SF0622	1.7e-190	671.8	Gammaproteobacteria													Escherichia	1MVDV@1224,1RP2Y@1236,COG1702@1,COG1702@2	NA|NA|NA	T	phosphate starvation-inducible protein PhoH
b0661	155864.EDL933_0739	7.5e-277	959.1	Escherichia	miaB	GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	2.8.4.3	ko:K06168			R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016				Escherichia	1MURS@1224,1RMD8@1236,3XP7C@561,COG0621@1,COG0621@2	NA|NA|NA	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
b0662	316407.4062280	2.9e-226	790.8	Escherichia	ubiF	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008682,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0016705,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663		ko:K03184	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R06146,R08775	RC01254	ko00000,ko00001,ko00002,ko01000			iAF1260.b0662,iBWG_1329.BWG_0533,iE2348C_1286.E2348C_0555,iECDH10B_1368.ECDH10B_0731,iECDH1ME8569_1439.ECDH1ME8569_0631,iETEC_1333.ETEC_0690,iEcDH1_1363.EcDH1_2964,iEcHS_1320.EcHS_A0709,iJO1366.b0662,iJR904.b0662,iSBO_1134.SBO_0526,iSbBS512_1146.SbBS512_E0585,iUMNK88_1353.UMNK88_700,iY75_1357.Y75_RS03450	Escherichia	1MU6I@1224,1RND5@1236,3XM7R@561,COG0654@1,COG0654@2	NA|NA|NA	CH	2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity
b0674	316407.1651277	0.0	1139.8	Escherichia	asnB	GO:0000166,GO:0003674,GO:0003824,GO:0004066,GO:0004071,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006541,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016054,GO:0016211,GO:0016597,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0017076,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110		R00578	RC00010	ko00000,ko00001,ko01000,ko01002			iB21_1397.B21_00622,iECBD_1354.ECBD_2988,iECB_1328.ECB_00631,iECD_1391.ECD_00631,iEcHS_1320.EcHS_A0717,iEcolC_1368.EcolC_2982	Escherichia	1MW4E@1224,1RQ7D@1236,3XMEF@561,COG0367@1,COG0367@2	NA|NA|NA	E	Asparagine synthetase B
b0675	155864.EDL933_0743	5.7e-143	513.5	Escherichia	nagD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658		ko:K02566					ko00000				Escherichia	1QGX4@1224,1RRS1@1236,3XMSZ@561,COG0647@1,COG0647@2	NA|NA|NA	G	Catalyzes the dephosphorylation of an unusually broad range of substrate including deoxyribo- and ribonucleoside tri-, di-, and monophosphates, as well as polyphosphate and glucose-1-P (Glu1P)
b0676	155864.EDL933_0744	2.2e-229	801.2	Escherichia	nagC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K02565					ko00000,ko03000				Escherichia	1NFM0@1224,1RNEA@1236,3XMAK@561,COG1846@1,COG1846@2,COG1940@1,COG1940@2	NA|NA|NA	K	Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon
b0677	155864.EDL933_0745	5.7e-219	766.5	Escherichia	nagA	GO:0003674,GO:0003824,GO:0005488,GO:0006040,GO:0006044,GO:0006046,GO:0006054,GO:0006082,GO:0008150,GO:0008152,GO:0008270,GO:0008448,GO:0009056,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0016999,GO:0017001,GO:0017144,GO:0019213,GO:0019262,GO:0019752,GO:0022607,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046348,GO:0046395,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130		R02059	RC00166,RC00300	ko00000,ko00001,ko01000			iEcolC_1368.EcolC_2979	Escherichia	1MW8Y@1224,1RMRV@1236,3XNPT@561,COG1820@1,COG1820@2	NA|NA|NA	G	Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D-glucosamine-6-phosphate, N-acetyl-D- glucosamine-6-sulfate, N-acetyl-D-galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate
b0678	1440052.EAKF1_ch0785	1.9e-152	545.0	Escherichia	nagB	GO:0003674,GO:0003824,GO:0004342,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0006044,GO:0006046,GO:0006047,GO:0006048,GO:0006054,GO:0006082,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016054,GO:0016787,GO:0016853,GO:0016860,GO:0016861,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0019239,GO:0019262,GO:0019438,GO:0019752,GO:0034641,GO:0034654,GO:0042737,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046348,GO:0046349,GO:0046395,GO:0046483,GO:0055086,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901362,GO:1901575,GO:1901576	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100		R00765	RC00163	ko00000,ko00001,ko01000			iZ_1308.Z0825	Escherichia	1MVEA@1224,1RQ2V@1236,3XNCZ@561,COG0363@1,COG0363@2	NA|NA|NA	F	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
b0679	316407.1651288	0.0	1194.1	Escherichia	nagE	GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009401,GO:0009987,GO:0015144,GO:0015764,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0033554,GO:0034219,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0090563,GO:0090586,GO:1901264	2.7.1.193	ko:K02802,ko:K02803,ko:K02804	ko00520,ko02060,map00520,map02060	M00267	R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7		iECP_1309.ECP_0691	Escherichia	1MY1V@1224,1RMYZ@1236,3XM9K@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2	NA|NA|NA	G	PTS system, N-acetylglucosamine-specific
b0680	316407.4062281	0.0	1154.4	Escherichia	glnS	GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iECIAI39_1322.ECIAI39_0637	Escherichia	1MUC8@1224,1RQ7G@1236,3XP56@561,COG0008@1,COG0008@2	NA|NA|NA	J	glutaminyl-tRNA aminoacylation
b0681	316407.85674737	5.3e-283	979.5	Escherichia	chiP	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015267,GO:0015772,GO:0022803,GO:0022838,GO:0022857,GO:0051179,GO:0051234,GO:0052778,GO:0052779,GO:0055085,GO:0071702,GO:0071704,GO:1901135											Escherichia	1NDEQ@1224,1RMG0@1236,2C471@1,2Z7J2@2,3XPEX@561	NA|NA|NA	M	amino disaccharide metabolic process
b0682	316407.4062283	7.6e-52	209.5	Escherichia	ybfN												Escherichia	1RHF9@1224,1S6DX@1236,2AQ40@1,31F99@2,3XPPT@561	NA|NA|NA	M	YbfN-like lipoprotein
b0683	1440052.EAKF1_ch0779	5.7e-82	310.1	Escherichia	fur	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K03711					ko00000,ko03000				Escherichia	1RDWJ@1224,1S4H7@1236,3XMA8@561,COG0735@1,COG0735@2	NA|NA|NA	K	Acts as a global negative controlling element, employing Fe(2 ) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon
b0684	155864.EDL933_0756	1.9e-100	371.7	Escherichia	fldA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K03839					ko00000				Escherichia	1MX7F@1224,1RMNT@1236,3XMN6@561,COG0716@1,COG0716@2	NA|NA|NA	C	Low-potential electron donor to a number of redox enzymes
b0685	155864.EDL933_0757	3.8e-42	177.2	Escherichia	ybfE	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1MZBR@1224,1S9W6@1236,2DB8J@1,32TX0@2,3XPUR@561	NA|NA|NA	S	regulation of nucleic acid-templated transcription
b0686	316407.4062286	6.2e-145	520.0	Escherichia	ybfF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0016790,GO:0044424,GO:0044444,GO:0044464,GO:0052689		ko:K01175					ko00000,ko01000				Escherichia	1R9X7@1224,1S2CW@1236,3XNID@561,COG0596@1,COG0596@2	NA|NA|NA	S	thiolester hydrolase activity
b0687	198214.SF0606	2.1e-94	351.7	Gammaproteobacteria													Escherichia	1MUW8@1224,1RQ83@1236,COG3057@1,COG3057@2	NA|NA|NA	L	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
b0688	316407.1651293	0.0	1093.6	Escherichia	pgm	GO:0000271,GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005996,GO:0006006,GO:0006012,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0016868,GO:0019318,GO:0019320,GO:0019388,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0055114,GO:0071704,GO:1901575,GO:1901576	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1376,iECED1_1282.ECED1_0670,iECNA114_1301.ECNA114_0627,iECOK1_1307.ECOK1_0699,iECP_1309.ECP_0709,iECS88_1305.ECS88_0725,iLF82_1304.LF82_1632,iNRG857_1313.NRG857_03110,iUMN146_1321.UM146_14115	Escherichia	1MU5S@1224,1RPDV@1236,3XNB7@561,COG0033@1,COG0033@2	NA|NA|NA	G	phosphoglucomutase activity
b0691	469008.B21_00639	4e-121	440.7	Gammaproteobacteria													Escherichia	1RD56@1224,1SNKN@1236,28NPX@1,2ZBPN@2	NA|NA|NA	S	Protein of unknown function DUF2625
b0692	199310.c0776	2.3e-240	837.8	Escherichia	potE	GO:0000064,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008519,GO:0015075,GO:0015101,GO:0015171,GO:0015179,GO:0015203,GO:0015238,GO:0015291,GO:0015293,GO:0015297,GO:0015298,GO:0015318,GO:0015489,GO:0015491,GO:0015496,GO:0015695,GO:0015696,GO:0015711,GO:0015807,GO:0015822,GO:0015846,GO:0015847,GO:0015849,GO:0015893,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655,GO:0098656,GO:0099516,GO:1902047,GO:1902475,GO:1903352,GO:1903825,GO:1905039		ko:K03756					ko00000,ko02000	2.A.3.2		iAF1260.b0692,iB21_1397.B21_00640,iBWG_1329.BWG_0551,iE2348C_1286.E2348C_0581,iECABU_c1320.ECABU_c07430,iECBD_1354.ECBD_2969,iECB_1328.ECB_00648,iECDH10B_1368.ECDH10B_0758,iECDH1ME8569_1439.ECDH1ME8569_0650,iECD_1391.ECD_00648,iECIAI1_1343.ECIAI1_0668,iECNA114_1301.ECNA114_0628,iECO103_1326.ECO103_0686,iECO26_1355.ECO26_0754,iECP_1309.ECP_0710,iECSE_1348.ECSE_0751,iECSF_1327.ECSF_0627,iECW_1372.ECW_m0742,iEKO11_1354.EKO11_3188,iETEC_1333.ETEC_0708,iEcDH1_1363.EcDH1_2945,iEcolC_1368.EcolC_2964,iJO1366.b0692,iJR904.b0692,iSSON_1240.SSON_0643,iUMNK88_1353.UMNK88_728,iWFL_1372.ECW_m0742,iY75_1357.Y75_RS03590,ic_1306.c0776	Escherichia	1MUA2@1224,1RPP7@1236,3XMDH@561,COG0531@1,COG0531@2	NA|NA|NA	E	Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity
b0693	316407.1651300	0.0	1514.6	Escherichia	speF	GO:0003674,GO:0003824,GO:0004586,GO:0005488,GO:0008144,GO:0016829,GO:0016830,GO:0016831,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000			iECW_1372.ECW_m0743,iWFL_1372.ECW_m0743	Escherichia	1MWK4@1224,1RMVF@1236,3XN9N@561,COG1982@1,COG1982@2	NA|NA|NA	E	Ornithine decarboxylase
b4590	469008.B21_04286	1.5e-42	178.3	Escherichia	ybfK												Escherichia	1PAJD@1224,1SVGZ@1236,2CANG@1,2ZQAY@2,3XREI@561	NA|NA|NA		
b0694	316407.85674742	3.5e-123	447.6	Escherichia	kdpE	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K07667	ko02020,ko02024,map02020,map02024	M00454			ko00000,ko00001,ko00002,ko02022				Escherichia	1MWZ5@1224,1RNY2@1236,3XP6Y@561,COG0745@1,COG0745@2	NA|NA|NA	K	KDP operon transcriptional regulatory protein KdpE
b0695	316407.1651302	0.0	1754.2	Escherichia	kdpD	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0007154,GO:0007165,GO:0008134,GO:0008150,GO:0008152,GO:0009593,GO:0009605,GO:0009628,GO:0009651,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031668,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051606,GO:0051716,GO:0065007,GO:0071214,GO:0071470,GO:0071472,GO:0071496,GO:0071704,GO:0071944,GO:0104004,GO:0140096,GO:1901564	2.7.13.3	ko:K07646	ko02020,map02020	M00454			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1MUZQ@1224,1RMZT@1236,3XMJ0@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
b0696	316407.1651303	5.4e-93	347.1	Escherichia	kdpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.12	ko:K01548	ko02020,map02020				ko00000,ko00001,ko01000	3.A.3.7			Escherichia	1RABG@1224,1RZ90@1236,3XPMQ@561,COG2156@1,COG2156@2	NA|NA|NA	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the
b0697	316407.85674743	0.0	1275.0	Escherichia	kdpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.12	ko:K01547	ko02020,map02020				ko00000,ko00001,ko01000	3.A.3.7		iECNA114_1301.ECNA114_0634,iECSF_1327.ECSF_0632	Escherichia	1MU7D@1224,1RPPF@1236,3XMHA@561,COG2216@1,COG2216@2	NA|NA|NA	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
b0698	316407.1651307	1.1e-306	1058.5	Escherichia	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.12	ko:K01546	ko02020,map02020				ko00000,ko00001,ko01000	3.A.3.7		iAPECO1_1312.APECO1_1369,iECUMN_1333.ECUMN_0780	Escherichia	1MV1K@1224,1RQZU@1236,3XM6D@561,COG2060@1,COG2060@2	NA|NA|NA	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
b0699	155864.EDL933_0769	1.7e-33	147.9	Escherichia	ybfA	GO:0008150,GO:0009314,GO:0009628,GO:0050896											Escherichia	1N75R@1224,1SCNU@1236,2E70C@1,331J8@2,3XPZX@561	NA|NA|NA	S	response to radiation
b0700	316407.1651309	0.0	2443.7	Escherichia	rhsC												Escherichia	1MVV1@1224,1SKYM@1236,3XQSX@561,COG3209@1,COG3209@2	NA|NA|NA	M	Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell
b0702	316407.4062295	1.8e-48	198.4	Gammaproteobacteria													Escherichia	1P7KU@1224,1SUIK@1236,28UM6@1,2ZGRQ@2	NA|NA|NA		
b0703	316407.1651310	7.5e-293	1012.3	Bacteria													Escherichia	COG3209@1,COG3209@2	NA|NA|NA	M	self proteolysis
b0704	316407.4062296	2.7e-105	387.9	Gammaproteobacteria													Escherichia	1NUYT@1224,1SNRB@1236,2F2KC@1,33VH6@2	NA|NA|NA		
b4514	316407.4062297	4.3e-42	176.8	Gammaproteobacteria													Escherichia	1MXB5@1224,1RSAV@1236,COG5433@1,COG5433@2	NA|NA|NA	L	Transposase
b0705	481805.EcolC_2950	1.4e-200	705.3	Escherichia													Escherichia	1MXB5@1224,1RSAV@1236,3XQUD@561,COG5433@1,COG5433@2	NA|NA|NA	L	transposase
b0706	316407.4062299	1.2e-145	522.3	Gammaproteobacteria													Escherichia	1MXB5@1224,1RSAV@1236,COG5433@1,COG5433@2	NA|NA|NA	L	Transposase
b0707	316407.4062300	4.6e-96	357.1	Escherichia	ybgA												Escherichia	1MXYZ@1224,1RNMF@1236,3XNUT@561,COG3272@1,COG3272@2	NA|NA|NA	S	Protein of unknown function (DUF1722)
b0708	316407.1651311	1.1e-283	981.9	Escherichia	phrB	GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0018298,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140097,GO:1901564	4.1.99.3	ko:K01669					ko00000,ko01000,ko03400				Escherichia	1MV9Y@1224,1RNGJ@1236,3XMSK@561,COG0415@1,COG0415@2	NA|NA|NA	L	Deoxyribodipyrimidine photo-lyase
b0709	316407.85674744	1.7e-279	968.0	Escherichia	dtpD	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0042886,GO:0042938,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03305					ko00000	2.A.17		iECO103_1326.ECO103_0702	Escherichia	1MW6W@1224,1RM8P@1236,3XM6J@561,COG3104@1,COG3104@2	NA|NA|NA	U	proton-dependent permease that transports dipeptides
b0710	155864.EDL933_0776	4.8e-142	510.4	Escherichia	ybgI	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896											Escherichia	1MVUN@1224,1RNBU@1236,3XP2E@561,COG0327@1,COG0327@2	NA|NA|NA	S	Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides
b0711	155864.EDL933_0777	3.4e-123	447.6	Escherichia	ybgJ												Escherichia	1MWRB@1224,1RQIQ@1236,3XNDW@561,COG2049@1,COG2049@2	NA|NA|NA	E	5-oxoprolinase (ATP-hydrolyzing) activity
b0712	316407.4062308	4.5e-182	643.7	Escherichia	ybgK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MU9H@1224,1RR39@1236,3XNFI@561,COG1984@1,COG1984@2	NA|NA|NA	E	5-oxoprolinase (ATP-hydrolyzing) activity
b0713	316407.4062309	1.3e-131	475.7	Escherichia	ybgL			ko:K07160					ko00000				Escherichia	1MUYV@1224,1RSCZ@1236,3XNRV@561,COG1540@1,COG1540@2	NA|NA|NA	S	Belongs to the UPF0271 (lamB) family
b0714	316407.4062310	1.3e-153	548.9	Escherichia	nei	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K05522	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Escherichia	1N1J5@1224,1RNS9@1236,3XPFM@561,COG0266@1,COG0266@2	NA|NA|NA	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates
b0715	316407.85674745	2.1e-180	638.3	Escherichia	abrB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07120					ko00000				Escherichia	1MUFS@1224,1RPMJ@1236,3XNU4@561,COG3180@1,COG3180@2	NA|NA|NA	S	regulation of gene expression
b0716	316407.85674746	1e-206	725.7	Escherichia	ybgO												Escherichia	1R706@1224,1S0UV@1236,3XND1@561,COG3539@1,COG3539@2	NA|NA|NA	NU	May be involved in a fimbrial system chaperoned by
b0717	316407.4062313	4e-133	480.7	Escherichia	ybgP	GO:0006457,GO:0008150,GO:0009987											Escherichia	1MY06@1224,1RN7Y@1236,3XPFT@561,COG3121@1,COG3121@2	NA|NA|NA	M	chaperone
b0718	316407.85674747	0.0	1653.3	Escherichia	ybgQ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944											Escherichia	1P744@1224,1RN8Z@1236,3XMSW@561,COG3188@1,COG3188@2	NA|NA|NA	NU	outer membrane usher protein
b0719	316407.4062315	3.4e-100	370.9	Escherichia	ybgD												Escherichia	1N3XD@1224,1SBRY@1236,3XQQJ@561,COG3539@1,COG3539@2	NA|NA|NA	NU	cell adhesion
b0720	199310.c0796	4.1e-250	870.2	Escherichia	gltA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000				Escherichia	1MUKX@1224,1RNDK@1236,3XMKA@561,COG0372@1,COG0372@2	NA|NA|NA	C	Belongs to the citrate synthase family
b0721	316407.1651317	1.5e-62	245.4	Escherichia	sdhC	GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0008177,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016635,GO:0017004,GO:0020037,GO:0022607,GO:0022900,GO:0034622,GO:0043933,GO:0044085,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0048038,GO:0048039,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0097159,GO:1901363		ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002			iSF_1195.SF0576,iS_1188.S0589	Escherichia	1RIGZ@1224,1S5ZE@1236,3XPJC@561,COG2009@1,COG2009@2	NA|NA|NA	C	Succinate dehydrogenase cytochrome b556 subunit
b0722	198214.SF0575	1.6e-47	195.3	Gammaproteobacteria													Escherichia	1MZR9@1224,1S9TS@1236,COG2142@1,COG2142@2	NA|NA|NA	C	Succinate dehydrogenase hydrophobic membrane anchor subunit
b0723	155864.EDL933_0792	0.0	1195.6	Escherichia	sdhA	GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_0603	Escherichia	1MU5M@1224,1RMU2@1236,3XNV2@561,COG1053@1,COG1053@2	NA|NA|NA	C	the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth
b0724	316407.1651320	1.6e-139	501.9	Escherichia	sdhB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			e_coli_core.b0724,iAF1260.b0724,iBWG_1329.BWG_0583,iEC042_1314.EC042_0742,iECDH10B_1368.ECDH10B_0791,iECDH1ME8569_1439.ECDH1ME8569_0683,iECUMN_1333.ECUMN_0802,iEcDH1_1363.EcDH1_2911,iJO1366.b0724,iJR904.b0724,iY75_1357.Y75_RS03765	Escherichia	1MVHS@1224,1RNWR@1236,3XNT4@561,COG0479@1,COG0479@2	NA|NA|NA	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
b0726	155864.EDL933_0795	0.0	1902.5	Escherichia	sucA	GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0030976,GO:0032991,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0046872,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000			iSSON_1240.SSON_0677	Escherichia	1MVBF@1224,1RN8K@1236,3XMF3@561,COG0567@1,COG0567@2	NA|NA|NA	F	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
b0727	155864.EDL933_0796	4.2e-196	690.6	Escherichia	sucB	GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722	Escherichia	1MUJD@1224,1RME0@1236,3XP92@561,COG0508@1,COG0508@2	NA|NA|NA	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)
b0728	155864.EDL933_0797	1.2e-216	758.8	Escherichia	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009361,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0042709,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000			iUMNK88_1353.UMNK88_764	Escherichia	1MVCE@1224,1RMSU@1236,3XMIP@561,COG0045@1,COG0045@2	NA|NA|NA	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
b0729	155864.EDL933_0798	1.3e-159	568.9	Escherichia	sucD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009361,GO:0009987,GO:0016310,GO:0019538,GO:0032991,GO:0036211,GO:0042709,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0046777,GO:0071704,GO:1901564,GO:1902494	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_0608	Escherichia	1MUGA@1224,1RM7Y@1236,3XPB9@561,COG0074@1,COG0074@2	NA|NA|NA	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
b0730	316407.85674749	6.3e-131	473.4	Escherichia	mngR	GO:0003674,GO:0003700,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K11922					ko00000,ko03000				Escherichia	1MUEB@1224,1RRAM@1236,3XR94@561,COG2188@1,COG2188@2	NA|NA|NA	K	response to heat
b0731	316407.85674750	0.0	1165.6	Escherichia	mngA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015711,GO:0015849,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0051476,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090581,GO:1901264,GO:1901656	2.7.1.195	ko:K11198,ko:K11199,ko:K11200	ko02060,map02060	M00305	R11169	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.3		iECO26_1355.ECO26_0791	Escherichia	1PF9N@1224,1RQCI@1236,3XRKC@561,COG1299@1,COG1299@2,COG1445@1,COG1445@2,COG1762@1,COG1762@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannosyl-D-glycerate transport. Also involved in thermoinduction of ompC
b0732	316407.4062319	0.0	1790.4	Gammaproteobacteria													Escherichia	1R3Q8@1224,1RSGZ@1236,COG0383@1,COG0383@2	NA|NA|NA	G	Alpha-Mannosidase
b0733	155864.EDL933_0812	1.8e-295	1021.1	Escherichia	cydA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3		iSFxv_1172.SFxv_0621,iS_1188.S0577	Escherichia	1MV60@1224,1RN2U@1236,3XNDG@561,COG1271@1,COG1271@2	NA|NA|NA	C	A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton electron
b0734	155864.EDL933_0813	2.2e-215	754.6	Escherichia	cydB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3			Escherichia	1MURP@1224,1RP7F@1236,3XN5E@561,COG1294@1,COG1294@2	NA|NA|NA	C	A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton electron
b4515	1440052.EAKF1_ch0734c	1.2e-12	77.8	Proteobacteria													Escherichia	1NGDQ@1224,COG4890@1,COG4890@2	NA|NA|NA	S	Cyd operon protein YbgT
b0735	155864.EDL933_0815	6e-48	196.4	Escherichia	ybgE											iECW_1372.ECW_m0790,iWFL_1372.ECW_m0790	Escherichia	1MZDH@1224,1SA3Q@1236,3XPW9@561,COG3790@1,COG3790@2	NA|NA|NA	S	Cyd operon protein YbgE (Cyd_oper_YbgE)
b0736	754331.AEME01000001_gene1226	1.2e-67	262.3	Escherichia	ybgC	GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0016790		ko:K07107					ko00000,ko01000			iSDY_1059.SDY_0684	Escherichia	1MZH6@1224,1S93F@1236,3XPK1@561,COG0824@1,COG0824@2	NA|NA|NA	S	Thioesterase-like superfamily
b0737	1440052.EAKF1_ch0731c	6.9e-119	433.3	Escherichia	tolQ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0017038,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03562	ko01120,map01120				ko00000,ko02000	1.A.30.2.2			Escherichia	1NCWW@1224,1RMD4@1236,3XN9R@561,COG0811@1,COG0811@2	NA|NA|NA	U	Involved in the TonB-independent uptake of
b0738	155864.EDL933_0818	4.1e-69	267.3	Escherichia	tolR	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K03560					ko00000,ko02000	1.A.30.2.2			Escherichia	1MZ6M@1224,1S8RS@1236,3XPID@561,COG0848@1,COG0848@2	NA|NA|NA	U	involved in the tonB-independent uptake of group A colicins
b0739	155864.EDL933_0819	1.1e-48	201.1	Escherichia	tolA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0016032,GO:0017038,GO:0019058,GO:0019904,GO:0030260,GO:0031224,GO:0031226,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044403,GO:0044409,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046677,GO:0046678,GO:0046718,GO:0046790,GO:0050896,GO:0051179,GO:0051234,GO:0051301,GO:0051701,GO:0051704,GO:0051716,GO:0051806,GO:0051828,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:0071944,GO:0097718,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701		ko:K03646					ko00000,ko02000	2.C.1.2			Escherichia	1MVQS@1224,1RP2V@1236,3XNNC@561,COG3064@1,COG3064@2	NA|NA|NA	U	Involved in the TonB-independent uptake of group A colicins (colicins A, E1, E2, E3, and K). Necessary for the colicins to reach their respective targets after initial binding to the bacteria. Also involved in the translocation of bacteriophage DNA
b0740	155864.EDL933_0820	4.9e-158	564.3	Escherichia	tolB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019904,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701		ko:K03641					ko00000,ko02000	2.C.1.2			Escherichia	1MV09@1224,1RMCY@1236,3XP8Z@561,COG0823@1,COG0823@2	NA|NA|NA	U	Involved in the TonB-independent uptake of
b0741	155864.EDL933_0821	2.5e-89	334.7	Escherichia	pal	GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032153,GO:0044425,GO:0044462,GO:0044464,GO:0051301,GO:0071944,GO:0098552		ko:K03640					ko00000,ko02000	2.C.1.2			Escherichia	1MZTV@1224,1S8RG@1236,3XMTD@561,COG2885@1,COG2885@2	NA|NA|NA	M	Thought to play a role in bacterial envelope integrity. Very strongly associated with the peptidoglycan
b0742	316407.4062322	1.3e-81	309.7	Escherichia	ybgF	GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043933,GO:0044085,GO:0044464,GO:0051259,GO:0051260,GO:0051301,GO:0065003,GO:0071840											Escherichia	1MUSV@1224,1RQWA@1236,3XMDS@561,COG1729@1,COG1729@2	NA|NA|NA	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
b0750	316407.1651334	9.2e-200	702.6	Escherichia	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_1338,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iZ_1308.Z0919	Escherichia	1MWQU@1224,1RMFS@1236,3XMW5@561,COG0379@1,COG0379@2	NA|NA|NA	F	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
b0751	198214.SF0553	2.7e-126	458.0	Gammaproteobacteria													Escherichia	1MXN4@1224,1RMZE@1236,COG3201@1,COG3201@2	NA|NA|NA	H	nicotinamide mononucleotide transporter
b0752	316407.4062324	4.6e-174	617.1	Escherichia	zitB	GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662		ko:K16264					ko00000,ko02000	2.A.4.1		iNRG857_1313.NRG857_03325	Escherichia	1MVQB@1224,1RMR8@1236,3XMQK@561,COG1230@1,COG1230@2	NA|NA|NA	P	Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc
b0753	198214.SF0551	5.4e-57	226.9	Gammaproteobacteria													Escherichia	1REV6@1224,1S3VK@1236,2AAK7@1,30ZXQ@2	NA|NA|NA	S	YbgS-like protein
b0754	155864.EDL933_0827	4.5e-202	710.3	Escherichia	aroG	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_0684,iECSF_1327.ECSF_0680,iEcSMS35_1347.EcSMS35_0777,iLF82_1304.LF82_0146,iNRG857_1313.NRG857_03335	Escherichia	1MU5Q@1224,1RMAA@1236,3XMQ0@561,COG0722@1,COG0722@2	NA|NA|NA	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
b0755	155864.EDL933_0828	1.3e-142	512.3	Escherichia	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147				Escherichia	1MUVE@1224,1RNCX@1236,3XMC6@561,COG0588@1,COG0588@2	NA|NA|NA	F	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily
b0756	198214.SF0548	6.2e-204	716.5	Gammaproteobacteria													Escherichia	1MVMN@1224,1RNZN@1236,COG2017@1,COG2017@2	NA|NA|NA	G	converts alpha-aldose to the beta-anomer
b0757	155864.EDL933_0831	6.3e-218	763.1	Escherichia	galK	GO:0000287,GO:0003674,GO:0003824,GO:0004335,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006012,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0046872,GO:0071704,GO:1901575	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147			iAF1260.b0757,iAPECO1_1312.APECO1_1331,iBWG_1329.BWG_0609,iEC55989_1330.EC55989_0736,iECABU_c1320.ECABU_c07960,iECB_1328.ECB_00710,iECDH1ME8569_1439.ECDH1ME8569_0710,iECH74115_1262.ECH74115_0860,iECIAI1_1343.ECIAI1_0725,iECNA114_1301.ECNA114_0687,iECO103_1326.ECO103_0745,iECOK1_1307.ECOK1_0757,iECP_1309.ECP_0768,iECS88_1305.ECS88_0773,iECSE_1348.ECSE_0810,iECSF_1327.ECSF_0683,iECSP_1301.ECSP_0810,iECW_1372.ECW_m0812,iECs_1301.ECs0785,iEKO11_1354.EKO11_3129,iETEC_1333.ETEC_0761,iEcDH1_1363.EcDH1_2885,iEcE24377_1341.EcE24377A_0784,iEcolC_1368.EcolC_2905,iG2583_1286.G2583_0923,iJO1366.b0757,iJR904.b0757,iLF82_1304.LF82_0794,iNRG857_1313.NRG857_03350,iUMN146_1321.UM146_13870,iUMNK88_1353.UMNK88_796,iUTI89_1310.UTI89_C0754,iWFL_1372.ECW_m0812,iY75_1357.Y75_RS03945,ic_1306.c0833	Escherichia	1MVQD@1224,1RQ0C@1236,3XP8E@561,COG0153@1,COG0153@2	NA|NA|NA	F	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
b0758	316407.1651343	9.9e-210	735.7	Escherichia	galT	GO:0003674,GO:0003824,GO:0004335,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006012,GO:0006793,GO:0006796,GO:0008108,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019200,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0046872,GO:0046914,GO:0070569,GO:0071704,GO:1901575	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_0842	Escherichia	1MU3E@1224,1RMDK@1236,3XM5X@561,COG1085@1,COG1085@2	NA|NA|NA	C	Belongs to the galactose-1-phosphate uridylyltransferase type 1 family
b0759	316407.1651344	2.1e-201	708.0	Escherichia	galE	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0003978,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006012,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901575,GO:1901576	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000			iSF_1195.SF0545,iSFxv_1172.SFxv_0601,iS_1188.S0553	Escherichia	1MUHI@1224,1RMTU@1236,3XP3B@561,COG1087@1,COG1087@2	NA|NA|NA	M	UDP-glucose 4-epimerase
b0760	316407.4062327	4.7e-282	976.5	Escherichia	modF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K05776	ko02010,map02010	M00189			ko00000,ko00001,ko00002,ko02000				Escherichia	1MVVM@1224,1RMXK@1236,3XNSI@561,COG1119@1,COG1119@2	NA|NA|NA	P	Involved in the transport of molybdenum into the cell. Involved in photorepair. Could act on UV-induced DNA damage other than pyrimidine dimers
b0761	155864.EDL933_0835	2.5e-141	508.1	Escherichia	modE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02019					ko00000,ko03000				Escherichia	1P9SX@1224,1RMES@1236,3XMNJ@561,COG2005@1,COG2005@2,COG3585@1,COG3585@2	NA|NA|NA	K	The ModE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA region, upstream of the modABC operon
b0762	155864.EDL933_0836	1.8e-16	90.9	Escherichia	ybhT												Escherichia	1NHYI@1224,1SGXU@1236,2EGRQ@1,33AHW@2,3XQ3R@561	NA|NA|NA	U	AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export
b0763	316407.1651348	6.7e-139	500.0	Escherichia	modA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015098,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015412,GO:0015689,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030151,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0034220,GO:0042597,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043169,GO:0043225,GO:0043492,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0099133,GO:1901359		ko:K02020	ko02010,map02010	M00189			ko00000,ko00001,ko00002,ko02000	3.A.1.8		iECO111_1330.ECO111_0773	Escherichia	1MVNA@1224,1RN71@1236,3XP51@561,COG0725@1,COG0725@2	NA|NA|NA	P	Molybdate-binding periplasmic
b0764	155864.EDL933_0838	1.1e-119	436.0	Escherichia	modB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02018	ko02010,map02010	M00189			ko00000,ko00001,ko00002,ko02000	3.A.1.8		iECO103_1326.ECO103_0752	Escherichia	1MUXR@1224,1RRDV@1236,3XMCK@561,COG4149@1,COG4149@2	NA|NA|NA	P	Molybdenum transport system permease protein ModB
b0765	316407.1651350	1.8e-198	698.4	Escherichia	modC	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.29	ko:K02017	ko02010,map02010	M00189			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8		iECNA114_1301.ECNA114_0696,iECSF_1327.ECSF_0691,iUMNK88_1353.UMNK88_805	Escherichia	1MU8K@1224,1RQCV@1236,3XNBJ@561,COG4148@1,COG4148@2	NA|NA|NA	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
b0766	316407.4062333	6.4e-156	556.6	Escherichia	ybhA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033883,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050308										iECSP_1301.ECSP_0819,iECs_1301.ECs0794,iG2583_1286.G2583_0932,iZ_1308.Z0936	Escherichia	1PGMI@1224,1RPYI@1236,3XPBW@561,COG0561@1,COG0561@2	NA|NA|NA	S	Pyridoxal phosphate phosphatase YbhA
b0767	316407.4062334	3.1e-197	694.1	Escherichia	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0017057,GO:0044424,GO:0044444,GO:0044464,GO:0052689	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000			iSSON_1240.SSON_0741	Escherichia	1MWGS@1224,1RNX2@1236,3XMN9@561,COG2706@1,COG2706@2	NA|NA|NA	F	Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
b0768	316407.4062335	3.7e-179	634.0	Escherichia	ybhD	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363,GO:1990837											Escherichia	1MUWX@1224,1RYWC@1236,3XMJF@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
b0769	199310.c0846	7.4e-197	693.0	Escherichia	ybhH												Escherichia	1MXVV@1224,1RNE6@1236,3XM4F@561,COG2828@1,COG2828@2	NA|NA|NA	S	isomerase activity
b0770	316407.4062337	6.8e-262	909.4	Escherichia	ybhI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03319					ko00000	2.A.47		iSF_1195.SF0891,iS_1188.S0938	Escherichia	1MUSA@1224,1RMF3@1236,3XP6G@561,COG0471@1,COG0471@2	NA|NA|NA	P	sodium ion transport
b0771	316407.85674754	0.0	1515.4	Escherichia	ybhJ	GO:0006950,GO:0006979,GO:0008150,GO:0050896	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000				Escherichia	1R4PE@1224,1S0EY@1236,3XNEB@561,COG1048@1,COG1048@2	NA|NA|NA	C	response to oxidative stress
b0772	316407.85674755	3e-245	854.0	Escherichia	ybhC	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	3.1.1.11	ko:K01051	ko00040,ko01100,map00040,map01100	M00081	R02362	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000				Escherichia	1MWT0@1224,1RRUY@1236,3XPDY@561,COG4677@1,COG4677@2	NA|NA|NA	M	Pectinesterase
b0773	316407.85674756	5.5e-91	340.1	Escherichia	ybhB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464		ko:K06910					ko00000				Escherichia	1N0Y4@1224,1S400@1236,3XMZJ@561,COG1881@1,COG1881@2	NA|NA|NA	S	Phosphatidylethanolamine-binding protein
b0774	316407.85674757	4.7e-254	883.2	Escherichia	bioA	GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007			iUTI89_1310.UTI89_C0772,iZ_1308.Z0993	Escherichia	1MU2N@1224,1RP0W@1236,3XP4Z@561,COG0161@1,COG0161@2	NA|NA|NA	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
b0775	316407.85674758	6.6e-198	696.4	Escherichia	bioB	GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z0994	Escherichia	1MVFF@1224,1RMEQ@1236,3XME5@561,COG0502@1,COG0502@2	NA|NA|NA	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
b0776	316407.85674759	7e-217	759.6	Escherichia	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007			iSDY_1059.SDY_0830	Escherichia	1MVVH@1224,1RNS6@1236,3XM4H@561,COG0156@1,COG0156@2	NA|NA|NA	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide
b0777	316407.85674760	8e-145	519.6	Escherichia	bioC	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0010340,GO:0016053,GO:0016740,GO:0016741,GO:0017144,GO:0018130,GO:0019752,GO:0032259,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_0791,iSBO_1134.SBO_0664,iSSON_1240.SSON_0756,iSbBS512_1146.SbBS512_E2575	Escherichia	1PA5F@1224,1RY7A@1236,3XP7T@561,COG0500@1,COG2226@2	NA|NA|NA	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway
b0778	316407.85674761	5.3e-124	450.3	Escherichia	bioD	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_0821,iECIAI1_1343.ECIAI1_0813,iECO103_1326.ECO103_0813,iECO111_1330.ECO111_0839,iECO26_1355.ECO26_0904,iECSE_1348.ECSE_0831,iECW_1372.ECW_m0833,iEKO11_1354.EKO11_3108,iEcE24377_1341.EcE24377A_0841,iSFV_1184.SFV_0761,iSSON_1240.SSON_0757,iWFL_1372.ECW_m0833,ic_1306.c0858	Escherichia	1RDRK@1224,1RSHS@1236,3XNCC@561,COG0132@1,COG0132@2	NA|NA|NA	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
b0779	155864.EDL933_0900	0.0	1300.4	Escherichia	uvrB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391		ko:K03702	ko03420,map03420				ko00000,ko00001,ko03400				Escherichia	1MUFK@1224,1RN6Z@1236,3XMDY@561,COG0556@1,COG0556@2	NA|NA|NA	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
b0780	316407.4062340	9.3e-164	582.8	Escherichia	ybhK												Escherichia	1NW3K@1224,1RQP9@1236,3XPC9@561,COG0391@1,COG0391@2	NA|NA|NA	S	Required for morphogenesis under gluconeogenic growth conditions
b0781	316407.1651354	1.1e-191	675.6	Escherichia	moaA	GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016829,GO:0016830,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0061798,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09394	RC03420	ko00000,ko00001,ko01000			iSbBS512_1146.SbBS512_E2571,ic_1306.c0862	Escherichia	1MW3W@1224,1RR68@1236,3XM5E@561,COG2896@1,COG2896@2	NA|NA|NA	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
b0782	155864.EDL933_0903	7.7e-91	339.7	Escherichia	moaB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100		R09726	RC00002	ko00000,ko00001,ko01000				Escherichia	1R9W2@1224,1S21E@1236,3XP2R@561,COG0521@1,COG0521@2	NA|NA|NA	H	May be involved in the biosynthesis of molybdopterin
b0783	155864.EDL933_0904	5.6e-83	313.5	Escherichia	moaC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0034214,GO:0042802,GO:0043170,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0061799,GO:0065003,GO:0071704,GO:0071840,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122		R11372	RC03425	ko00000,ko00001,ko01000				Escherichia	1RCYZ@1224,1S3ST@1236,3XNPB@561,COG0315@1,COG0315@2	NA|NA|NA	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)
b0784	316407.1651357	6.1e-38	162.9	Escherichia	moaD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576		ko:K03636	ko04122,map04122				ko00000,ko00001			iE2348C_1286.E2348C_0736,iEC55989_1330.EC55989_0827,iG2583_1286.G2583_1012,iLF82_1304.LF82_1368,iNRG857_1313.NRG857_03495	Escherichia	1N0IE@1224,1S8S1@1236,3XQ05@561,COG1977@1,COG1977@2	NA|NA|NA	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
b0785	316407.4062341	1.4e-83	315.5	Escherichia	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122		R09395	RC02507	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1305,iEC042_1314.EC042_0869,iEC55989_1330.EC55989_0828,iECABU_c1320.ECABU_c08270,iECED1_1282.ECED1_0750,iECIAI1_1343.ECIAI1_0820,iECIAI39_1322.ECIAI39_0761,iECNA114_1301.ECNA114_0717,iECO103_1326.ECO103_0820,iECO111_1330.ECO111_0846,iECO26_1355.ECO26_0911,iECOK1_1307.ECOK1_0787,iECP_1309.ECP_0799,iECS88_1305.ECS88_0802,iECSE_1348.ECSE_0839,iECSF_1327.ECSF_0711,iECW_1372.ECW_m0841,iEKO11_1354.EKO11_3101,iEcE24377_1341.EcE24377A_0848,iG2583_1286.G2583_1013,iLF82_1304.LF82_1369,iNRG857_1313.NRG857_03500,iSSON_1240.SSON_0764,iUMN146_1321.UM146_13720,iUTI89_1310.UTI89_C0785,iWFL_1372.ECW_m0841,ic_1306.c0867	Escherichia	1RGUX@1224,1S5YH@1236,3XPIK@561,COG0314@1,COG0314@2	NA|NA|NA	H	Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD
b0786	199310.c0868	1.5e-116	425.6	Escherichia	ybhL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K06890					ko00000				Escherichia	1MU69@1224,1RN8Q@1236,3XNCH@561,COG0670@1,COG0670@2	NA|NA|NA	S	Inhibitor of apoptosis-promoting Bax1
b0787	316407.4062344	2.5e-124	451.4	Escherichia	ybhM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K06890					ko00000				Escherichia	1NN7Z@1224,1SIS9@1236,3XR8E@561,COG0670@1,COG0670@2	NA|NA|NA	S	Belongs to the BI1 family
b0788	316407.4062345	4.4e-172	610.5	Escherichia	ybhN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07027					ko00000,ko02000	4.D.2			Escherichia	1MXH9@1224,1RS5E@1236,3XP2Z@561,COG0392@1,COG0392@2	NA|NA|NA	S	Lysylphosphatidylglycerol synthase TM region
b0789	155864.EDL933_0910	4e-234	817.0	Escherichia	clsB	GO:0003674,GO:0003824,GO:0004620,GO:0004630,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008081,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016298,GO:0016740,GO:0016772,GO:0016780,GO:0016787,GO:0016788,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576		ko:K06131	ko00564,ko01100,map00564,map01100		R07390	RC00017	ko00000,ko00001,ko01000			iECED1_1282.ECED1_0754	Escherichia	1MWUW@1224,1RNEC@1236,3XMFM@561,COG1502@1,COG1502@2	NA|NA|NA	I	Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
b0790	155864.EDL933_0911	2.4e-149	534.6	Escherichia	ybhP												Escherichia	1MVN7@1224,1RNSP@1236,3XNI0@561,COG3568@1,COG3568@2	NA|NA|NA	L	Endonuclease/Exonuclease/phosphatase family
b0791	155864.EDL933_0912	5.6e-68	263.5	Escherichia	ybhQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1REJF@1224,1S4G4@1236,2CICU@1,2ZPQP@2,3XPKZ@561	NA|NA|NA	S	Putative inner membrane protein YbhQ
b0792	1440052.EAKF1_ch0678	5.2e-201	706.8	Escherichia	ybhR	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944		ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Escherichia	1MW5R@1224,1SYDD@1236,3XP79@561,COG0842@1,COG0842@2	NA|NA|NA	V	efflux transmembrane transporter activity
b0793	155864.EDL933_0914	8.2e-202	709.5	Escherichia	ybhS	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K01992		M00254			ko00000,ko00002,ko02000	3.A.1			Escherichia	1MW5R@1224,1RPB4@1236,3XPH4@561,COG0842@1,COG0842@2	NA|NA|NA	V	transmembrane transport
b0794	198214.SF0744	0.0	1163.3	Gammaproteobacteria													Escherichia	1MUX3@1224,1RMM4@1236,COG1131@1,COG1131@2	NA|NA|NA	V	(ABC) transporter
b0795	316407.4062353	1.2e-108	399.8	Escherichia	ybhG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944		ko:K01993					ko00000				Escherichia	1MUG6@1224,1RP16@1236,3XNN2@561,COG0845@1,COG0845@2	NA|NA|NA	M	UPF0194 membrane protein YbhG
b0796	155864.EDL933_0917	1.7e-122	445.3	Escherichia	ybiH	GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031333,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2000144,GO:2001141											Escherichia	1NDME@1224,1RQQB@1236,3XNKM@561,COG1309@1,COG1309@2	NA|NA|NA	K	Transcriptional regulator
b0797	155864.EDL933_0918	4.3e-221	773.9	Escherichia	rhlE	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K11927	ko03018,map03018				ko00000,ko00001,ko01000,ko03019				Escherichia	1MU49@1224,1RMWA@1236,3XPAR@561,COG0513@1,COG0513@2	NA|NA|NA	F	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA
b0798	316407.4062356	8.3e-87	326.2	Escherichia	ybiA	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016070,GO:0016787,GO:0016798,GO:0016799,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901135,GO:1901360		ko:K09935					ko00000				Escherichia	1RK58@1224,1T154@1236,3XQJM@561,COG3236@2,COG5113@1	NA|NA|NA	O	Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. Helps maintain flavin levels. May act on other substrates in vivo. Has no activity against GTP, nucleoside monophosphates or ADP-ribose. Is Required for swarming motility
b0799	316407.1651361	0.0	1422.1	Escherichia	dinG	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008026,GO:0008094,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0033554,GO:0033677,GO:0033680,GO:0042623,GO:0048037,GO:0050896,GO:0051276,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0070035,GO:0071103,GO:0071496,GO:0071840,GO:0140097,GO:0140098	3.6.4.12	ko:K03722					ko00000,ko01000,ko03400				Escherichia	1MVCU@1224,1RMNX@1236,3XNY4@561,COG1199@1,COG1199@2	NA|NA|NA	L	helicase involved in DNA repair and perhaps also replication
b0800	316407.4062361	1e-184	652.5	Escherichia	ybiB	GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363											Escherichia	1QJ8Q@1224,1RY26@1236,3XNKD@561,COG0547@1,COG0547@2	NA|NA|NA	E	transferase activity, transferring glycosyl groups
b0801	316407.4062362	1.3e-212	745.3	Escherichia	ybiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K13574					ko00000,ko01000				Escherichia	1MWQY@1224,1RSKW@1236,3XM36@561,COG2055@1,COG2055@2	NA|NA|NA	C	Catalyzes the NAD(P)H-dependent reduction of 2- oxoglutarate, phenylpyruvate and (4-hydroxyphenyl)pyruvate, leading to the respective 2-hydroxycarboxylate in vitro. Shows a preference for NADPH over NADH as a redox partner. Do not catalyze the reverse reactions
b0802	1440052.EAKF1_ch0668	7.5e-18	96.3	Escherichia	ybiJ	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1N77S@1224,1SCDN@1236,2E4GN@1,32ZBU@2,3XPWP@561	NA|NA|NA	S	cellular response to DNA damage stimulus
b0803	316407.4062364	3.7e-44	183.7	Escherichia	ybiI												Escherichia	1MZIB@1224,1S8SP@1236,3XPW0@561,COG1734@1,COG1734@2	NA|NA|NA	T	zinc ion binding
b0804	316407.85674765	9.7e-126	456.1	Escherichia	ybiX	GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0033554,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771		ko:K07336					ko00000,ko01000				Escherichia	1MUI7@1224,1RQ0M@1236,3XQE0@561,COG3128@1,COG3128@2	NA|NA|NA	S	PKHD-type hydroxylase YbiX
b0805	316407.4062366	0.0	1528.1	Escherichia	fiu	GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0015688,GO:0015833,GO:0015891,GO:0015893,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044462,GO:0044464,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:1901678		ko:K16090					ko00000,ko02000	1.B.14.1.11		iLF82_1304.LF82_0668,iNRG857_1313.NRG857_03600	Escherichia	1MV0X@1224,1RN3C@1236,3XQAN@561,COG4774@1,COG4774@2	NA|NA|NA	P	Involved in the active transport across the outer membrane of iron complexed with catecholate siderophores such as dihydroxybenzoylserine and dihydroxybenzoate. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Can also transport catechol-substituted cephalosporins. Receptor for microcins M, H47 and E492
b0806	155864.EDL933_0929	2.9e-38	164.1	Escherichia	mcbA	GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046377,GO:0071704,GO:1901135,GO:1901137,GO:1901576		ko:K13650					ko00000,ko02048				Escherichia	1ND9B@1224,1SEHC@1236,2DPRH@1,3333J@2,3XQ0C@561	NA|NA|NA	S	MqsR-controlled colanic acid and biofilm protein A
b0807	316407.85674767	2e-177	628.2	Escherichia	rlmF	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052907,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.181	ko:K06970			R07232	RC00003,RC00335	ko00000,ko01000,ko03009				Escherichia	1MUI4@1224,1RMVA@1236,3XNMU@561,COG3129@1,COG3129@2	NA|NA|NA	J	Specifically methylates the adenine in position 1618 of 23S rRNA
b0808	316407.85674768	0.0	1392.5	Escherichia	ybiO	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K22044					ko00000,ko02000	1.A.23.3			Escherichia	1MY0I@1224,1RQKY@1236,3XMNT@561,COG0668@1,COG0668@2	NA|NA|NA	M	ion transport
b0809	316407.1651363	5.3e-130	470.3	Escherichia	glnQ	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K10038	ko02010,map02010	M00227			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.2		e_coli_core.b0809,iAF1260.b0809,iB21_1397.B21_00793,iBWG_1329.BWG_0662,iECBD_1354.ECBD_2814,iECB_1328.ECB_00776,iECDH10B_1368.ECDH10B_0877,iECDH1ME8569_1439.ECDH1ME8569_0762,iECD_1391.ECD_00776,iETEC_1333.ETEC_0876,iEcDH1_1363.EcDH1_2833,iEcHS_1320.EcHS_A0865,iEcolC_1368.EcolC_2834,iJO1366.b0809,iJR904.b0809,iSBO_1134.SBO_0700,iSbBS512_1146.SbBS512_E2539,iUMNK88_1353.UMNK88_849,iY75_1357.Y75_RS04210	Escherichia	1MU9Q@1224,1RMX1@1236,3XM6H@561,COG1126@1,COG1126@2	NA|NA|NA	E	Glutamine transport ATP-binding protein glnQ
b0810	155864.EDL933_0933	1.1e-113	416.0	Escherichia	glnP	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K10037	ko02010,map02010	M00227			ko00000,ko00001,ko00002,ko02000	3.A.1.3.2		e_coli_core.b0810,iAF1260.b0810,iAPECO1_1312.APECO1_1281,iB21_1397.B21_00794,iBWG_1329.BWG_0663,iE2348C_1286.E2348C_0762,iEC042_1314.EC042_0900,iEC55989_1330.EC55989_0854,iECABU_c1320.ECABU_c08520,iECBD_1354.ECBD_2813,iECB_1328.ECB_00777,iECDH10B_1368.ECDH10B_0878,iECDH1ME8569_1439.ECDH1ME8569_0763,iECD_1391.ECD_00777,iECED1_1282.ECED1_0775,iECH74115_1262.ECH74115_0959,iECIAI1_1343.ECIAI1_0848,iECIAI39_1322.ECIAI39_0788,iECNA114_1301.ECNA114_0743,iECO103_1326.ECO103_0846,iECOK1_1307.ECOK1_0813,iECP_1309.ECP_0824,iECS88_1305.ECS88_0828,iECSE_1348.ECSE_0866,iECSF_1327.ECSF_0736,iECSP_1301.ECSP_0907,iECUMN_1333.ECUMN_0954,iECW_1372.ECW_m0866,iECs_1301.ECs0888,iEKO11_1354.EKO11_3076,iETEC_1333.ETEC_0877,iEcDH1_1363.EcDH1_2832,iEcE24377_1341.EcE24377A_0879,iEcHS_1320.EcHS_A0866,iEcSMS35_1347.EcSMS35_0834,iEcolC_1368.EcolC_2833,iG2583_1286.G2583_1038,iJO1366.b0810,iJR904.b0810,iLF82_1304.LF82_0854,iNRG857_1313.NRG857_03630,iSBO_1134.SBO_0701,iSDY_1059.SDY_0786,iSFV_1184.SFV_0794,iSF_1195.SF0761,iSFxv_1172.SFxv_0829,iSSON_1240.SSON_0790,iS_1188.S0803,iUMN146_1321.UM146_13595,iUMNK88_1353.UMNK88_850,iUTI89_1310.UTI89_C0813,iWFL_1372.ECW_m0866,iY75_1357.Y75_RS04215,iZ_1308.Z1032,ic_1306.c0895	Escherichia	1MX3E@1224,1RS0Y@1236,3XN98@561,COG0765@1,COG0765@2	NA|NA|NA	P	probably responsible for the translocation of the substrate across the membrane
b0811	155864.EDL933_0934	5.1e-136	490.3	Escherichia	glnH	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K10036	ko02010,map02010	M00227			ko00000,ko00001,ko00002,ko02000	3.A.1.3.2			Escherichia	1MV3Q@1224,1RRI5@1236,3XMFU@561,COG0834@1,COG0834@2	NA|NA|NA	ET	glutamine-binding periplasmic protein
b0812	155864.EDL933_0935	8.6e-87	326.2	Escherichia	dps	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0006950,GO:0008150,GO:0008199,GO:0009295,GO:0009605,GO:0009991,GO:0031667,GO:0042594,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050896,GO:0097159,GO:1901363		ko:K04047					ko00000,ko03036				Escherichia	1RAC5@1224,1RR4N@1236,3XN85@561,COG0783@1,COG0783@2	NA|NA|NA	P	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
b0813	199310.c0899	4.5e-155	553.9	Escherichia	rhtA	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015195,GO:0015238,GO:0015318,GO:0015562,GO:0015565,GO:0015711,GO:0015804,GO:0015807,GO:0015826,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0034639,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K11939					ko00000,ko02000	2.A.7.3.6		iNRG857_1313.NRG857_03645	Escherichia	1MXR7@1224,1RPFH@1236,3XN3H@561,COG5006@1,COG5006@2	NA|NA|NA	S	Involved in the efflux of threonine and homoserine
b0814	155864.EDL933_0937	5.4e-92	343.6	Escherichia	ompX	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K11934					ko00000,ko02000	1.B.6.2.1			Escherichia	1RAHA@1224,1S1ZI@1236,3XPDG@561,COG3637@1,COG3637@2	NA|NA|NA	M	Outer membrane protein X
b0815	316407.4062378	4.1e-308	1063.1	Escherichia	ybiP	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016776,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509											Escherichia	1NHRY@1224,1RS8R@1236,3XPEH@561,COG2194@1,COG2194@2	NA|NA|NA	S	sulfuric ester hydrolase activity
b4705	155864.EDL933_0939	2.6e-16	90.1	Escherichia													Escherichia	1NJQ0@1224,1SGFP@1236,2EH7F@1,33AZ9@2,3XQ5F@561	NA|NA|NA		
b0817	199310.c0903	1.6e-79	302.0	Escherichia	mntR	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031334,GO:0032991,GO:0032993,GO:0043254,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000144,GO:2001141		ko:K11924					ko00000,ko03000				Escherichia	1RH2Z@1224,1S2NA@1236,3XM8T@561,COG1321@1,COG1321@2	NA|NA|NA	K	In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP
b0818	316407.4062385	1.6e-205	721.8	Escherichia	ybiR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1NEVR@1224,1RQVD@1236,3XMSH@561,COG1055@1,COG1055@2	NA|NA|NA	P	transmembrane transport
b0819	199310.c0905	2e-174	618.2	Escherichia	ybiS	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0034645,GO:0042546,GO:0042597,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0070004,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576		ko:K19235					ko00000,ko01002,ko01011				Escherichia	1MVYT@1224,1RMNC@1236,3XM5D@561,COG1376@1,COG1376@2	NA|NA|NA	M	Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp)
b0820	155864.EDL933_0943	4e-303	1046.6	Escherichia	ybiT	GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0050896											Escherichia	1MU37@1224,1RPN9@1236,3XM3N@561,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter, ATP-binding protein
b0821	316407.4062388	9.3e-255	885.6	Escherichia	ybiU												Escherichia	1QT0R@1224,1RP98@1236,2CK8J@1,2Z7SR@2,3XPAS@561	NA|NA|NA	S	Protein of unknown function (DUF1479)
b0822	316407.4062389	7.3e-152	543.1	Escherichia	ybiV	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0050308	3.1.3.23	ko:K07757			R00804		ko00000,ko01000			iECO103_1326.ECO103_0866,iLF82_1304.LF82_2649,iNRG857_1313.NRG857_03685	Escherichia	1Q5HK@1224,1RQ8H@1236,3XNYT@561,COG0561@1,COG0561@2	NA|NA|NA	S	Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of ribose-5-phosphate, glucose-6-phosphate, fructose-1-phosphate, acetyl-phosphate, glycerol-1-phosphate, glycerol-2-phosphate, 2-deoxy-glucose-6-phosphate, mannose-6- phosphate and fructose-6-phosphate. Appears to have a low level of phosphotransferase activity using monophosphates as the phosphate donor
b0823	316407.85674770	0.0	1640.6	Escherichia	ybiW	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120		R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000				Escherichia	1MWBF@1224,1RMEK@1236,3XN60@561,COG1882@1,COG1882@2	NA|NA|NA	C	formate C-acetyltransferase activity
b0824	316407.4062398	2.1e-176	624.8	Escherichia	ybiY		1.97.1.4	ko:K04069			R04710		ko00000,ko01000				Escherichia	1QJHU@1224,1RQUF@1236,3XP0Z@561,COG1180@1,COG1180@2	NA|NA|NA	O	Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
b0825	316407.85674771	1.7e-114	418.7	Escherichia	fsaA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016832,GO:0044424,GO:0044464,GO:0097023		ko:K08313					ko00000,ko01000			iEC042_1314.EC042_0914,iSBO_1134.SBO_0715,iSF_1195.SF0775,iSFxv_1172.SFxv_0845,iS_1188.S0818	Escherichia	1MWQ8@1224,1RNWN@1236,3XP1P@561,COG0176@1,COG0176@2	NA|NA|NA	G	Catalyzes the reversible formation of fructose 6- phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction
b0826	316407.1651375	4.7e-137	493.8	Escherichia	moeB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0061605,GO:0070566,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.80	ko:K21029	ko04122,map04122		R07459	RC00043	ko00000,ko00001,ko01000			iECIAI1_1343.ECIAI1_0865,iECW_1372.ECW_m0884,iEKO11_1354.EKO11_3059,iETEC_1333.ETEC_0893,iEcE24377_1341.EcE24377A_0897,iEcSMS35_1347.EcSMS35_0851,iWFL_1372.ECW_m0884	Escherichia	1MW7H@1224,1RPJ3@1236,3XMVK@561,COG0476@1,COG0476@2	NA|NA|NA	H	molybdopterin-synthase adenylyltransferase activity
b0827	316407.1651376	1.4e-234	818.5	Escherichia	moeA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0042802,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100		R09735	RC03462	ko00000,ko00001,ko01000			iEcHS_1320.EcHS_A0885	Escherichia	1MVD5@1224,1RMQU@1236,3XN1A@561,COG0303@1,COG0303@2	NA|NA|NA	H	Molybdopterin
b0828	316407.4062400	7.8e-177	626.3	Escherichia	iaaA	GO:0003674,GO:0003824,GO:0004067,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008798,GO:0010467,GO:0016485,GO:0016540,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.19.5	ko:K13051					ko00000,ko01000,ko01002			iZ_1308.Z1051m	Escherichia	1MWFC@1224,1RNUR@1236,3XPAN@561,COG1446@1,COG1446@2	NA|NA|NA	E	Degrades proteins damaged by L-isoaspartyl residue formation (also known as beta-Asp residues). Degrades L- isoaspartyl-containing di- and maybe also tripeptides. Also has L- asparaginase activity, although this may not be its principal function
b0829	511145.b0829	0.0	1202.6	Escherichia	gsiA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K13892	ko02010,map02010	M00348			ko00000,ko00001,ko00002,ko02000	3.A.1.5.11		iSbBS512_1146.SbBS512_E2519	Escherichia	1MU09@1224,1RMEI@1236,3XNVV@561,COG1123@1,COG4172@2	NA|NA|NA	P	Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system
b0830	316407.85674773	4.1e-297	1026.5	Escherichia	gsiB	GO:0005575,GO:0005623,GO:0006810,GO:0006857,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071702,GO:0071705		ko:K13889	ko02010,map02010	M00348			ko00000,ko00001,ko00002,ko02000	3.A.1.5.11		iNRG857_1313.NRG857_03725	Escherichia	1MUZH@1224,1RNFB@1236,3XMYQ@561,COG0747@1,COG0747@2	NA|NA|NA	E	Part of the ABC transporter complex GsiABCD involved in glutathione import
b0831	316407.4062408	4.1e-167	594.0	Escherichia	gsiC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K13890	ko02010,map02010	M00348			ko00000,ko00001,ko00002,ko02000	3.A.1.5.11		ic_1306.c0916	Escherichia	1MU8Z@1224,1RNJ1@1236,3XMKP@561,COG0601@1,COG0601@2	NA|NA|NA	EP	Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane
b0832	316407.4062409	9e-151	539.7	Escherichia	gsiD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K13891	ko02010,map02010	M00348			ko00000,ko00001,ko00002,ko02000	3.A.1.5.11		iECABU_c1320.ECABU_c08730,iECP_1309.ECP_0846,ic_1306.c0917	Escherichia	1MWMX@1224,1RNBC@1236,3XMH1@561,COG1173@1,COG1173@2	NA|NA|NA	EP	Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane
b0833	316407.4062410	0.0	1546.2	Escherichia	yliE	GO:0003674,GO:0003824,GO:0008081,GO:0016787,GO:0016788,GO:0042578,GO:0071111											Escherichia	1N299@1224,1T2T4@1236,3XNPI@561,COG2200@1,COG2200@2	NA|NA|NA	T	Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
b0834	316407.4062411	3.4e-247	860.5	Escherichia	yliF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944										iSBO_1134.SBO_0726	Escherichia	1R80Z@1224,1RZUV@1236,3XNK5@561,COG2199@1,COG2199@2	NA|NA|NA	T	diguanylate cyclase activity
b0835	155864.EDL933_0962	5e-259	899.8	Escherichia	rimO	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564	2.8.4.4	ko:K14441			R10652	RC00003,RC03217	ko00000,ko01000,ko03009				Escherichia	1MU7N@1224,1RN46@1236,3XM3X@561,COG0621@1,COG0621@2	NA|NA|NA	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
b0836	155864.EDL933_0963	4.6e-64	250.4	Escherichia	bssR	GO:0008150,GO:0010468,GO:0019222,GO:0043900,GO:0050789,GO:0050794,GO:0060255,GO:0065007,GO:1900190		ko:K19688					ko00000,ko02048				Escherichia	1RE5M@1224,1S45I@1236,29WPV@1,30IAT@2,3XPW2@561	NA|NA|NA	S	Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway
b0837	316407.4062422	3.4e-224	783.9	Escherichia	yliI	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363		ko:K21430					ko00000,ko01000			iSbBS512_1146.SbBS512_E2507	Escherichia	1MV2E@1224,1RNGN@1236,3XMGG@561,COG2133@1,COG2133@2	NA|NA|NA	G	Can oxidize glucose to gluconolactone. Can also utilize D-arabinose, L- arabinose and 2-deoxy-glucose. Has higher activity towards oligomeric sugars, such as maltose, maltotriose or cellobiose. It may function to input sugar-derived electrons into the respiratory network
b0838	155864.EDL933_0965	1.8e-118	431.8	Escherichia	yliJ	GO:0003674,GO:0003824,GO:0004364,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016740,GO:0016765,GO:0030611,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418		R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2			Escherichia	1RA4M@1224,1S2K3@1236,3XNCW@561,COG0625@1,COG0625@2	NA|NA|NA	O	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
b0839	316407.1651381	1.6e-227	795.0	Escherichia	dacC	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008360,GO:0008658,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100				ko00000,ko00001,ko01000,ko01002,ko01011			iSbBS512_1146.SbBS512_E2506	Escherichia	1MUU7@1224,1RMJA@1236,3XMW7@561,COG1686@1,COG1686@2	NA|NA|NA	M	Belongs to the peptidase S11 family
b0840	155864.EDL933_0967	5.2e-144	516.9	Escherichia	deoR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141		ko:K11534					ko00000,ko03000				Escherichia	1MY40@1224,1RR32@1236,3XN6U@561,COG1349@1,COG1349@2	NA|NA|NA	K	This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming protein). The inducer is deoxyribose-5-phosphate
b0841	316407.85674774	8.6e-110	402.9	Escherichia	ybjG	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0042221,GO:0044464,GO:0046677,GO:0050380,GO:0050896,GO:0071944	3.6.1.27	ko:K19302	ko00550,map00550		R05627	RC00002	ko00000,ko00001,ko01000,ko01011			iEC042_1314.EC042_0932	Escherichia	1R56P@1224,1RRTS@1236,3XPFA@561,COG0671@1,COG0671@2	NA|NA|NA	I	Overexpression leads to increased undecaprenyl diphosphatase activity and to increased resistance to bacitracin. May have a preferred substrate other than undecaprenyl diphosphate in vivo
b0842	155864.EDL933_0969	2.6e-225	787.7	Escherichia	mdfA	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006855,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0015893,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0035725,GO:0042221,GO:0042493,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600		ko:K08160					ko00000,ko01504,ko02000	2.A.1.2.19		iSFV_1184.SFV_0827	Escherichia	1MUWH@1224,1RRF6@1236,3XPGY@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b0843	198214.SF0796	6.9e-25	119.8	Gammaproteobacteria													Escherichia	1N6A5@1224,1SBQ1@1236,2DZVA@1,32VJW@2	NA|NA|NA		
b0844	316407.85674775	3.6e-151	540.8	Escherichia	ybjI	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043726,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.102,3.1.3.104	ko:K20861	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R07280	RC00017	ko00000,ko00001,ko00002,ko01000				Escherichia	1Q5HK@1224,1RQ8H@1236,3XN2K@561,COG0561@1,COG0561@2	NA|NA|NA	S	Catalyzes the dephosphorylation of 5-amino-6-(5-phospho- D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway. Is also able to dephosphorylate flavin mononucleotide (FMN), erythrose 4-phosphate and other phosphoric acid esters
b0845	316407.4062429	2.8e-208	731.1	Escherichia	ybjJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MVR9@1224,1RNEI@1236,3XNSE@561,COG0738@1,COG0738@2	NA|NA|NA	G	transmembrane transport
b0846	316407.85674776	6e-94	350.1	Escherichia	ybjK	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:1990837,GO:2000112,GO:2001141											Escherichia	1R94Q@1224,1S24A@1236,3XMEA@561,COG3226@1,COG3226@2	NA|NA|NA	K	Regulates the expression of a number of genes involved in biofilm formation and stress response. Target genes include six stress-response transcriptional regulators csgD, which is a master regulator of biofilm formation, appY, sxy, ycgF, fimB and rcdA itself. This indicates that a large number of genes must be regulated indirectly via these transcriptional regulators. Acts by binding to the upstream region of its target genes
b0847	155864.EDL933_0974	4.7e-311	1072.8	Escherichia	ybjL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07085					ko00000	2.A.81			Escherichia	1MUVM@1224,1RQ47@1236,3XMX3@561,COG0569@1,COG0569@2,COG2985@1,COG2985@2	NA|NA|NA	P	potassium ion transport
b0848	155864.EDL933_0975	1.3e-66	258.8	Escherichia	ybjM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RJKC@1224,1S7JU@1236,2AKS6@1,31BJ4@2,3XQ11@561	NA|NA|NA	S	Putative inner membrane protein of Enterobacteriaceae
b0849	198214.SF0802	3e-43	180.6	Gammaproteobacteria													Escherichia	1RGZ7@1224,1S5ZP@1236,COG0695@1,COG0695@2	NA|NA|NA	O	Glutaredoxin
b0850	316407.4062439	2.6e-40	171.0	Escherichia	ybjC	GO:0001101,GO:0005575,GO:0006950,GO:0008150,GO:0009635,GO:0009636,GO:0010033,GO:0016020,GO:0042221,GO:0050896,GO:0097305,GO:1901422,GO:1901562,GO:1901700											Escherichia	1NB1Y@1224,1S9M0@1236,2E45I@1,32Z1J@2,3XPXH@561	NA|NA|NA	S	response to herbicide
b0851	316407.1651385	4.2e-135	487.3	Escherichia	nfsA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0010181,GO:0016491,GO:0016651,GO:0016657,GO:0032553,GO:0034567,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K10678	ko00633,ko01120,map00633,map01120		R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000				Escherichia	1NIJ8@1224,1RMRT@1236,3XNFS@561,COG0778@1,COG0778@2	NA|NA|NA	C	Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major oxygen-insensitive nitroreductase in E.coli
b0852	155864.EDL933_0979	5.8e-166	590.1	Escherichia	rimK	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564		ko:K05844					ko00000,ko01000,ko03009				Escherichia	1MX62@1224,1RM8B@1236,3XMV6@561,COG0189@1,COG0189@2	NA|NA|NA	F	Is an L-glutamate ligase that catalyzes the ATP- dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH
b0853	155864.EDL933_0980	5e-84	317.0	Escherichia	ybjN	GO:0001558,GO:0008150,GO:0009297,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010639,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0030308,GO:0031344,GO:0031345,GO:0032879,GO:0033043,GO:0040008,GO:0040012,GO:0040013,GO:0043711,GO:0043900,GO:0043901,GO:0044085,GO:0044087,GO:0045926,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051270,GO:0051271,GO:0060491,GO:0065007,GO:0071840,GO:1900190,GO:1900191,GO:1900231,GO:1900232,GO:1902021,GO:1902115,GO:1902116,GO:1902201,GO:1902208,GO:1902209,GO:2000145,GO:2000146											Escherichia	1RAPN@1224,1S261@1236,2DC0R@1,2ZC96@2,3XNUI@561	NA|NA|NA	S	negative regulation of organelle assembly
b0854	316407.1651387	1.7e-215	755.0	Escherichia	potF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0019808,GO:0019810,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0051179,GO:0051234,GO:0070405,GO:0071702,GO:0071705		ko:K11073	ko02010,map02010	M00300			ko00000,ko00001,ko00002,ko02000	3.A.1.11.2		iB21_1397.B21_00865,iECBD_1354.ECBD_2740,iECB_1328.ECB_00859,iECD_1391.ECD_00859,iEcHS_1320.EcHS_A0957,iEcolC_1368.EcolC_2742	Escherichia	1MUYW@1224,1RM7W@1236,3XN5N@561,COG0687@1,COG0687@2	NA|NA|NA	P	Required for the activity of the bacterial periplasmic transport system of putrescine
b0855	198214.SF0809	8.4e-215	752.7	Gammaproteobacteria													Escherichia	1MU3I@1224,1RNPX@1236,COG3842@1,COG3842@2	NA|NA|NA	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
b0856	316407.1651389	1.7e-176	625.2	Escherichia	potH	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K11075	ko02010,map02010	M00300			ko00000,ko00001,ko00002,ko02000	3.A.1.11.2		iAF1260.b0856,iBWG_1329.BWG_0709,iE2348C_1286.E2348C_0853,iECDH10B_1368.ECDH10B_0926,iECDH1ME8569_1439.ECDH1ME8569_0808,iEcDH1_1363.EcDH1_2786,iJO1366.b0856,iJR904.b0856,iY75_1357.Y75_RS04455	Escherichia	1MVGM@1224,1RNNZ@1236,3XNG5@561,COG1176@1,COG1176@2	NA|NA|NA	P	Putrescine transport system permease protein PotH
b0857	1440052.EAKF1_ch0616c	4.3e-147	527.3	Escherichia	potI	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K11074	ko02010,map02010	M00300			ko00000,ko00001,ko00002,ko02000	3.A.1.11.2		iG2583_1286.G2583_1088,ic_1306.c0990	Escherichia	1MVC5@1224,1RQB7@1236,3XPAQ@561,COG1177@1,COG1177@2	NA|NA|NA	P	Required for the activity of the bacterial periplasmic transport system of putrescine
b0858	155864.EDL933_0987	4.3e-83	313.9	Escherichia	ybjO	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RGQB@1224,1S32T@1236,2E0RG@1,32W9M@2,3XPB5@561	NA|NA|NA	S	Protein of unknown function (DUF2593)
b0859	316407.4062444	1.7e-220	771.5	Escherichia	rlmC	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.189	ko:K03212					ko00000,ko01000,ko03009				Escherichia	1N8DN@1224,1RMX4@1236,3XP7M@561,COG2265@1,COG2265@2	NA|NA|NA	J	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA
b0860	316407.1651393	6.6e-136	490.0	Escherichia	artJ	GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0034618,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043090,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0097638,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902023,GO:1902475,GO:1903400,GO:1903825,GO:1903826,GO:1905039,GO:1990822		ko:K09996	ko02010,map02010	M00229			ko00000,ko00001,ko00002,ko02000	3.A.1.3.3		iG2583_1286.G2583_1094,iUMN146_1321.UM146_13350,iZ_1308.Z1090	Escherichia	1MXIA@1224,1RPXK@1236,3XPGU@561,COG0834@1,COG0834@2	NA|NA|NA	ET	belongs to the bacterial solute-binding protein 3 family
b0861	155864.EDL933_0994	1.4e-103	382.5	Escherichia	artM	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0097638,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902023,GO:1902475,GO:1903400,GO:1903825,GO:1903826,GO:1905039,GO:1990822		ko:K09998	ko02010,map02010	M00229			ko00000,ko00001,ko00002,ko02000	3.A.1.3.3		iAF1260.b0861,iAPECO1_1312.APECO1_1232,iB21_1397.B21_00872,iBWG_1329.BWG_0714,iE2348C_1286.E2348C_0858,iEC042_1314.EC042_0952,iEC55989_1330.EC55989_0906,iECABU_c1320.ECABU_c09020,iECBD_1354.ECBD_2733,iECB_1328.ECB_00866,iECDH10B_1368.ECDH10B_0931,iECDH1ME8569_1439.ECDH1ME8569_0813,iECD_1391.ECD_00866,iECED1_1282.ECED1_0826,iECH74115_1262.ECH74115_1021,iECIAI1_1343.ECIAI1_0900,iECIAI39_1322.ECIAI39_0841,iECNA114_1301.ECNA114_0803,iECO103_1326.ECO103_0905,iECO111_1330.ECO111_0930,iECO26_1355.ECO26_0988,iECOK1_1307.ECOK1_0863,iECP_1309.ECP_0876,iECS88_1305.ECS88_0879,iECSE_1348.ECSE_0919,iECSF_1327.ECSF_0786,iECSP_1301.ECSP_0964,iECW_1372.ECW_m0969,iECs_1301.ECs0944,iEKO11_1354.EKO11_2975,iETEC_1333.ETEC_0928,iEcDH1_1363.EcDH1_2781,iEcE24377_1341.EcE24377A_0934,iEcHS_1320.EcHS_A0965,iEcolC_1368.EcolC_2735,iG2583_1286.G2583_1095,iJO1366.b0861,iJR904.b0861,iLF82_1304.LF82_0155,iNRG857_1313.NRG857_03885,iSBO_1134.SBO_0795,iSFV_1184.SFV_0846,iSF_1195.SF0815,iSFxv_1172.SFxv_0883,iS_1188.S0857,iSbBS512_1146.SbBS512_E2470,iUMN146_1321.UM146_13345,iUMNK88_1353.UMNK88_957,iUTI89_1310.UTI89_C0864,iWFL_1372.ECW_m0969,iY75_1357.Y75_RS04480,iZ_1308.Z1091,ic_1306.c0994	Escherichia	1QV6B@1224,1RNC2@1236,3XNAT@561,COG4160@1,COG4160@2	NA|NA|NA	P	Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane
b0862	198214.SF0816	1.3e-125	455.7	Gammaproteobacteria													Escherichia	1NH6Q@1224,1RPY2@1236,COG4215@1,COG4215@2	NA|NA|NA	P	arginine transporter permease subunit ArtQ
b0863	316407.1651396	9.5e-135	486.1	Escherichia	artI	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K09997	ko02010,map02010	M00229			ko00000,ko00001,ko00002,ko02000	3.A.1.3.3		iLF82_1304.LF82_0153,iNRG857_1313.NRG857_03895	Escherichia	1MXIA@1224,1RPXK@1236,3XNZG@561,COG0834@1,COG0834@2	NA|NA|NA	ET	Belongs to the bacterial solute-binding protein 3 family
b0864	155864.EDL933_0997	2.3e-133	481.5	Escherichia	artP	GO:0003333,GO:0003674,GO:0003824,GO:0005215,GO:0005275,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015399,GO:0015405,GO:0015424,GO:0015426,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015837,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031263,GO:0032991,GO:0033283,GO:0033284,GO:0034220,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0043090,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0097638,GO:0098533,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:0098796,GO:0098797,GO:1902023,GO:1902475,GO:1902494,GO:1902495,GO:1903400,GO:1903825,GO:1903826,GO:1904949,GO:1905039,GO:1990351,GO:1990822		ko:K10000	ko02010,map02010	M00229			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.3		iAF1260.b0864,iB21_1397.B21_00875,iBWG_1329.BWG_0717,iE2348C_1286.E2348C_0861,iEC042_1314.EC042_0955,iEC55989_1330.EC55989_0909,iECABU_c1320.ECABU_c09050,iECBD_1354.ECBD_2730,iECB_1328.ECB_00869,iECDH10B_1368.ECDH10B_0934,iECD_1391.ECD_00869,iECED1_1282.ECED1_0829,iECH74115_1262.ECH74115_1024,iECIAI1_1343.ECIAI1_0903,iECIAI39_1322.ECIAI39_0844,iECNA114_1301.ECNA114_0806,iECO111_1330.ECO111_0933,iECO26_1355.ECO26_0991,iECOK1_1307.ECOK1_0866,iECP_1309.ECP_0879,iECS88_1305.ECS88_0882,iECSE_1348.ECSE_0922,iECSF_1327.ECSF_0789,iECSP_1301.ECSP_0967,iECUMN_1333.ECUMN_1057,iECs_1301.ECs0947,iETEC_1333.ETEC_0931,iEcDH1_1363.EcDH1_2778,iEcE24377_1341.EcE24377A_0937,iEcHS_1320.EcHS_A0968,iEcSMS35_1347.EcSMS35_0892,iEcolC_1368.EcolC_2732,iG2583_1286.G2583_1098,iJO1366.b0864,iJR904.b0864,iLF82_1304.LF82_0156,iNRG857_1313.NRG857_03900,iSBO_1134.SBO_0798,iSFV_1184.SFV_0849,iSF_1195.SF0818,iSFxv_1172.SFxv_0886,iSSON_1240.SSON_0849,iS_1188.S0860,iSbBS512_1146.SbBS512_E2467,iUMN146_1321.UM146_13330,iY75_1357.Y75_RS04495,iZ_1308.Z1094,ic_1306.c0997	Escherichia	1MU9Q@1224,1RMB1@1236,3XN1Y@561,COG1126@1,COG1126@2	NA|NA|NA	P	Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for energy coupling to the transport system
b0865	316407.4062445	5.7e-94	350.1	Escherichia	ybjP												Escherichia	1R5ZY@1224,1RRXU@1236,29BUY@1,2ZYT8@2,3XPJQ@561	NA|NA|NA	M	Protein of unknown function (DUF3828)
b0866	155864.EDL933_1000	1.7e-51	208.4	Escherichia	ybjQ												Escherichia	1N0XM@1224,1S62I@1236,3XPSK@561,COG0393@1,COG0393@2	NA|NA|NA	S	Belongs to the UPF0145 family
b0867	316407.4062447	1.1e-160	572.4	Escherichia	amiD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.5.1.28	ko:K11066					ko00000,ko01000,ko01011				Escherichia	1RDHU@1224,1RMDN@1236,3XNYK@561,COG3023@1,COG3023@2	NA|NA|NA	V	N-acetyl-anhydromuramoyl-L-alanine amidase activity
b0868	155864.EDL933_1002	1.2e-196	692.2	Escherichia	ybjS												Escherichia	1P603@1224,1RQ2R@1236,3XNMN@561,COG0451@1,COG0451@2	NA|NA|NA	M	coenzyme binding
b0869	316407.85674782	3e-278	963.8	Escherichia	ybjT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MW54@1224,1RNS7@1236,3XNJ2@561,COG0702@1,COG0702@2	NA|NA|NA	GM	Protein of unknown function (DUF2867)
b0870	316407.4062450	3.5e-188	664.1	Escherichia	ltaE	GO:0003674,GO:0003824,GO:0004793,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008732,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050179,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230		R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_0812,iECSF_1327.ECSF_0795	Escherichia	1MWCR@1224,1RNYX@1236,3XN44@561,COG2008@1,COG2008@2	NA|NA|NA	E	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates
b0871	316407.1651398	0.0	1140.6	Escherichia	poxB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009987,GO:0016020,GO:0016043,GO:0016054,GO:0016491,GO:0016903,GO:0019752,GO:0019842,GO:0022607,GO:0030976,GO:0032787,GO:0036094,GO:0042802,GO:0042867,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046872,GO:0048037,GO:0050660,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052737,GO:0052738,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901681	1.2.5.1	ko:K00156	ko00620,map00620		R03145	RC00860	ko00000,ko00001,ko01000			iSF_1195.SF0826,iSFxv_1172.SFxv_0895,iS_1188.S0867	Escherichia	1MWKP@1224,1RNYT@1236,3XNU3@561,COG0028@1,COG0028@2	NA|NA|NA	C	Belongs to the TPP enzyme family
b0872	316407.85674783	2.6e-188	664.5	Escherichia	hcr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0097159,GO:1901265,GO:1901363		ko:K11933					ko00000,ko01000				Escherichia	1MY2Q@1224,1RR5A@1236,3XMND@561,COG1018@1,COG1018@2	NA|NA|NA	C	NADH oxidoreductase
b0873	316407.85674784	0.0	1130.5	Escherichia	hcp	GO:0000302,GO:0001505,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0017144,GO:0034641,GO:0042133,GO:0042135,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0044237,GO:0044248,GO:0044270,GO:0046209,GO:0046210,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748,GO:2001057	1.7.99.1	ko:K05601	ko00910,map00910		R00143	RC02797	ko00000,ko00001,ko01000				Escherichia	1N88B@1224,1RP1I@1236,3XNJ6@561,COG0369@1,COG1151@2	NA|NA|NA	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O
b0874	316407.4062453	5.6e-153	547.0	Escherichia	ybjE	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015174,GO:0015179,GO:0015189,GO:0015238,GO:0015318,GO:0015562,GO:0015661,GO:0015711,GO:0015802,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0034639,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902022,GO:1902475,GO:1903401,GO:1903825,GO:1905039,GO:1990822											Escherichia	1MYMF@1224,1RP7N@1236,3XNZ1@561,COG2431@1,COG2431@2	NA|NA|NA	S	L-lysine efflux transmembrane transporter activity
b0875	198214.SF0832	4.6e-123	447.2	Gammaproteobacteria													Escherichia	1MXTJ@1224,1RPKU@1236,COG0580@1,COG0580@2	NA|NA|NA	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity
b0876	316407.4062459	0.0	1114.8	Escherichia	ybjD	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576		ko:K07459					ko00000				Escherichia	1N2CB@1224,1RQN2@1236,3XMAS@561,COG3593@1,COG3593@2	NA|NA|NA	L	DNA synthesis involved in DNA repair
b0877	316407.4062460	7.7e-188	662.9	Escherichia	ybjX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716		ko:K09824					ko00000				Escherichia	1NTXF@1224,1RPKK@1236,3XNPG@561,COG2990@1,COG2990@2	NA|NA|NA	S	cellular response to DNA damage stimulus
b0878	316407.4062462	3.6e-186	657.5	Escherichia	macA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0016020,GO:0016021,GO:0019898,GO:0022857,GO:0031224,GO:0032991,GO:0042221,GO:0042493,GO:0042802,GO:0042891,GO:0042895,GO:0044425,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796,GO:1902495,GO:1990195,GO:1990196,GO:1990351		ko:K13888		M00709			ko00000,ko00002,ko02000	8.A.1			Escherichia	1MU8D@1224,1RN0E@1236,3XNFK@561,COG0845@1,COG0845@2	NA|NA|NA	M	Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP-bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC
b0879	316407.4062463	0.0	1236.9	Escherichia	macB	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0008559,GO:0015238,GO:0015399,GO:0015405,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098796,GO:1902495,GO:1990195,GO:1990196,GO:1990351		ko:K05685	ko02010,map02010	M00709			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12			Escherichia	1MU45@1224,1RNUJ@1236,3XNDE@561,COG0577@1,COG0577@2,COG1136@1,COG1136@2	NA|NA|NA	V	Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation
b0880	1440052.EAKF1_ch0591	1.1e-36	158.7	Escherichia	cspD	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006275,GO:0006950,GO:0008150,GO:0008156,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009991,GO:0010556,GO:0010558,GO:0010605,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031667,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:2000112,GO:2000113		ko:K03704					ko00000,ko03000				Escherichia	1N6Q5@1224,1SCA7@1236,3XPZU@561,COG1278@1,COG1278@2	NA|NA|NA	K	Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single- stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells
b0881	155864.EDL933_1015	3.6e-54	217.2	Escherichia	clpS	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087		ko:K06891					ko00000				Escherichia	1MZU8@1224,1S8Z7@1236,3XPPB@561,COG2127@1,COG2127@2	NA|NA|NA	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
b0882	155864.EDL933_1016	0.0	1465.7	Escherichia	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564		ko:K03694					ko00000,ko03110				Escherichia	1MV8B@1224,1RMH3@1236,3XNJY@561,COG0542@1,COG0542@2	NA|NA|NA	O	ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins
b0884	1005994.GTGU_01094	4e-33	146.7	Gammaproteobacteria													Escherichia	1MZFU@1224,1S8WZ@1236,COG0361@1,COG0361@2	NA|NA|NA	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
b0885	198214.SF0844	5.5e-140	503.4	Gammaproteobacteria													Escherichia	1R9W8@1224,1S1ZB@1236,COG2360@1,COG2360@2	NA|NA|NA	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
b0886	316407.1651408	0.0	1076.6	Escherichia	cydC	GO:0000101,GO:0003333,GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006857,GO:0006865,GO:0008150,GO:0009889,GO:0015399,GO:0015405,GO:0015711,GO:0015804,GO:0015833,GO:0015849,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0031326,GO:0032973,GO:0032991,GO:0033228,GO:0034220,GO:0034635,GO:0034775,GO:0035443,GO:0035672,GO:0042623,GO:0042626,GO:0042883,GO:0042886,GO:0042939,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050789,GO:0050794,GO:0051171,GO:0051179,GO:0051181,GO:0051193,GO:0051234,GO:0055085,GO:0065007,GO:0070453,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0098533,GO:0098655,GO:0098656,GO:0098796,GO:0098797,GO:0140115,GO:1901401,GO:1901463,GO:1902494,GO:1902495,GO:1903712,GO:1903825,GO:1904949,GO:1905039,GO:1990351		ko:K16012	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1.129		iEC55989_1330.EC55989_0931,iECIAI1_1343.ECIAI1_0926,iECO103_1326.ECO103_0929,iECO111_1330.ECO111_0954,iECSE_1348.ECSE_0944,iECW_1372.ECW_m0996,iEKO11_1354.EKO11_2951,iSDY_1059.SDY_2375,iWFL_1372.ECW_m0996	Escherichia	1QU1P@1224,1RQD7@1236,3XNCD@561,COG4987@1,COG4987@2	NA|NA|NA	P	ATP-binding
b0887	316407.1651409	0.0	1133.2	Escherichia	cydD	GO:0000101,GO:0003333,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006857,GO:0006865,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0015399,GO:0015405,GO:0015711,GO:0015804,GO:0015833,GO:0015849,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019725,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032973,GO:0032991,GO:0033036,GO:0033228,GO:0034040,GO:0034220,GO:0034635,GO:0034775,GO:0035443,GO:0035672,GO:0042592,GO:0042623,GO:0042626,GO:0042883,GO:0042886,GO:0042939,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0045454,GO:0046942,GO:0050789,GO:0050794,GO:0051179,GO:0051181,GO:0051234,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0098533,GO:0098655,GO:0098656,GO:0098796,GO:0098797,GO:0140115,GO:1902494,GO:1902495,GO:1903712,GO:1903825,GO:1904949,GO:1905039,GO:1990351		ko:K16013	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1.129		iEC042_1314.EC042_0979,iECUMN_1333.ECUMN_1082,iETEC_1333.ETEC_0955	Escherichia	1QU1N@1224,1RNPI@1236,3XMAN@561,COG4988@1,COG4988@2	NA|NA|NA	P	ATP-binding
b0888	155864.EDL933_1151	3.3e-183	647.5	Escherichia	trxB	GO:0000166,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384	ko00450,map00450		R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000				Escherichia	1MV15@1224,1RMEX@1236,3XNJ5@561,COG0492@1,COG0492@2	NA|NA|NA	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
b0889	1440052.EAKF1_ch0581c	1.1e-86	325.9	Escherichia	lrp	GO:0000976,GO:0001067,GO:0001101,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009078,GO:0009080,GO:0009081,GO:0009082,GO:0009098,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016053,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046394,GO:0046395,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901698,GO:1901700,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K03719					ko00000,ko03000,ko03036				Escherichia	1MX7R@1224,1RPGA@1236,3XMYH@561,COG1522@1,COG1522@2	NA|NA|NA	K	lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes
b0890	316407.1651412	0.0	2120.9	Escherichia	ftsK	GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03466					ko00000,ko03036	3.A.12			Escherichia	1MVPI@1224,1RM9A@1236,3XN27@561,COG1178@1,COG1178@2,COG1674@1,COG1674@2	NA|NA|NA	D	Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif
b0891	155864.EDL933_1155	8.5e-113	412.9	Escherichia	lolA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0015031,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033036,GO:0034613,GO:0042597,GO:0042886,GO:0042953,GO:0042954,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0045184,GO:0051179,GO:0051234,GO:0051641,GO:0070727,GO:0071702,GO:0071705,GO:0072321,GO:0072322,GO:0072323,GO:0072657		ko:K03634					ko00000				Escherichia	1PXDV@1224,1S9FW@1236,3XNMD@561,COG2834@1,COG2834@2	NA|NA|NA	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
b0892	1440052.EAKF1_ch0578c	9.9e-255	885.6	Escherichia	rarA	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576		ko:K07478					ko00000				Escherichia	1MUVS@1224,1RPBY@1236,3XM8Q@561,COG2256@1,COG2256@2	NA|NA|NA	L	DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes
b0893	155864.EDL933_1157	1.7e-235	821.6	Escherichia	serS	GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iSDY_1059.SDY_2368	Escherichia	1MUJF@1224,1RNAQ@1236,3XM4W@561,COG0172@1,COG0172@2	NA|NA|NA	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
b0894	316407.85674786	0.0	1682.9	Escherichia	dmsA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009390,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494	1.8.5.3	ko:K07306	ko00920,map00920		R09501	RC02555	ko00000,ko00001,ko01000,ko02000	5.A.3.3		iECSE_1348.ECSE_0952	Escherichia	1NR6J@1224,1RMVE@1236,3XN4H@561,COG0243@1,COG0243@2	NA|NA|NA	C	Dimethyl sulfoxide reductase
b0895	1440052.EAKF1_ch0575c	6.1e-127	459.9	Escherichia	dmsB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009389,GO:0009390,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016667,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494		ko:K07307	ko00920,map00920		R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3			Escherichia	1MU5T@1224,1RPIC@1236,3XPBX@561,COG0437@1,COG0437@2	NA|NA|NA	C	Anaerobic dimethyl sulfoxide reductase chain B
b0896	316407.1651423	2.4e-153	548.1	Escherichia	dmsC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009389,GO:0009390,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016667,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0055114,GO:0071944,GO:1902494		ko:K07308	ko00920,map00920		R09501	RC02555	ko00000,ko00001,ko02000	5.A.3.3		iECO111_1330.ECO111_0964,iECO26_1355.ECO26_1022,iUTI89_1310.UTI89_C0969	Escherichia	1PA8U@1224,1RRGH@1236,3XP9S@561,COG3302@1,COG3302@2	NA|NA|NA	S	Dimethyl sulfoxide reductase
b0897	316407.4062471	1.2e-117	429.1	Escherichia	ycaC	GO:0003674,GO:0005488,GO:0005515,GO:0042802											Escherichia	1MWFQ@1224,1RMHF@1236,3XNGI@561,COG1335@1,COG1335@2	NA|NA|NA	Q	lyase activity
b0898	316407.4062472	3.8e-207	727.2	Escherichia	ycaD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08219					ko00000,ko02000	2.A.1.26			Escherichia	1QTUM@1224,1T1HT@1236,3XNEZ@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	MFS-type transporter YcaD
b0899	316407.85674787	4e-270	936.8	Escherichia	ycaM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MVTW@1224,1S0DS@1236,3XQKH@561,COG0531@1,COG0531@2	NA|NA|NA	P	transmembrane transporter activity
b0900	316407.4062476	1.2e-171	609.0	Escherichia	ycaN	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Escherichia	1MU2E@1224,1RYV3@1236,3XQZP@561,COG0583@1,COG0583@2	NA|NA|NA	K	sequence-specific DNA binding
b0901	316407.4062477	3.3e-114	417.5	Gammaproteobacteria													Escherichia	1MUHN@1224,1S24D@1236,COG2249@1,COG2249@2	NA|NA|NA	S	NAD(P)H dehydrogenase (quinone)
b0902	155864.EDL933_1165	4.9e-147	526.9	Escherichia	pflA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0018307,GO:0019538,GO:0033554,GO:0036211,GO:0043170,GO:0043364,GO:0043365,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070283,GO:0071704,GO:1901564	1.97.1.4	ko:K04069			R04710		ko00000,ko01000			iECOK1_1307.ECOK1_0925,iEcE24377_1341.EcE24377A_0980,iEcSMS35_1347.EcSMS35_2219	Escherichia	1NQC1@1224,1RNCR@1236,3XNPM@561,COG1180@1,COG1180@2	NA|NA|NA	O	under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
b0903	316407.1651427	0.0	1533.9	Escherichia	pflB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008861,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120		R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_1064,iECIAI39_1322.ECIAI39_2245,iECSP_1301.ECSP_1007,iECs_1301.ECs0986,iEcSMS35_1347.EcSMS35_2218,iG2583_1286.G2583_1138,iSDY_1059.SDY_2358,iZ_1308.Z1248	Escherichia	1MWBF@1224,1RM96@1236,3XMX2@561,COG1882@1,COG1882@2	NA|NA|NA	C	formate C-acetyltransferase activity
b0904	199310.c1042	5e-159	567.0	Escherichia	focA	GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015318,GO:0015499,GO:0015711,GO:0015718,GO:0015724,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K06212					ko00000,ko02000	1.A.16.1.1,1.A.16.1.3		iSF_1195.SF0899,iS_1188.S0963	Escherichia	1MU0W@1224,1RQ6K@1236,3XN70@561,COG2116@1,COG2116@2	NA|NA|NA	P	Involved in the bidirectional transport of formate
b0905	316407.85674788	0.0	1198.0	Escherichia	ycaO	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047429,GO:0047693,GO:0071704,GO:1901564		ko:K09136					ko00000,ko03009				Escherichia	1MV7K@1224,1RN47@1236,3XNVF@561,COG1944@1,COG1944@2	NA|NA|NA	S	ATP diphosphatase activity
b0906	316407.4062480	1.3e-125	455.7	Escherichia	ycaP												Escherichia	1MW5I@1224,1RS6M@1236,3XPE8@561,COG2323@1,COG2323@2	NA|NA|NA	S	Protein of unknown function (DUF421)
b0907	316407.1651429	4.2e-211	740.3	Escherichia	serC	GO:0003674,GO:0003824,GO:0004648,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006520,GO:0006553,GO:0006563,GO:0006564,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046394,GO:0046451,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901615,GO:1901617	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007			iEcE24377_1341.EcE24377A_1004	Escherichia	1MUB5@1224,1RMKU@1236,3XMMR@561,COG1932@1,COG1932@2	NA|NA|NA	H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
b0908	155864.EDL933_1171	7.5e-244	849.4	Escherichia	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_0940,iECSF_1327.ECSF_0829	Escherichia	1MWMK@1224,1RQ8U@1236,3XMZC@561,COG0128@1,COG0128@2	NA|NA|NA	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
b0909	316407.4062481	8.4e-134	483.0	Gammaproteobacteria													Escherichia	1NK9F@1224,1RQSJ@1236,COG0501@1,COG0501@2	NA|NA|NA	O	metalloprotease
b0910	155864.EDL933_1173	9.9e-118	429.5	Escherichia	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_2348	Escherichia	1MUUD@1224,1RNKT@1236,3XN6Y@561,COG0283@1,COG0283@2	NA|NA|NA	F	Belongs to the cytidylate kinase family. Type 1 subfamily
b0911	1440052.EAKF1_ch0546c	0.0	1080.5	Escherichia	rpsA	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113,GO:2000765,GO:2000766		ko:K02945	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1MVAV@1224,1RMFY@1236,3XMK6@561,COG0539@1,COG0539@2	NA|NA|NA	J	acts as an RNA chaperone to unfold structured mRNA on the ribosome but is not essential for mRNAs with strong SDs and little 5'-UTR structure, thus it may help fine-tune which mRNAs that are translated. Unwinds dsRNA by binding to transiently formed ssRNA regions
b0912	1440052.EAKF1_ch0545c	2.4e-46	191.0	Escherichia	ihfB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K05788					ko00000,ko03032,ko03036,ko03400				Escherichia	1MZ7M@1224,1S8XZ@1236,3XPWM@561,COG0776@1,COG0776@2	NA|NA|NA	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
b0913	316407.85674789	0.0	1556.2	Escherichia	ycaI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02238		M00429			ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2			Escherichia	1MUKF@1224,1RMW6@1236,3XNAX@561,COG0658@1,COG0658@2,COG2333@1,COG2333@2	NA|NA|NA	S	establishment of competence for transformation
b0914	155864.EDL933_1177	3.4e-308	1063.5	Escherichia	msbA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K11085	ko02010,map02010				ko00000,ko00001,ko01000,ko02000	3.A.1.106		iUMN146_1321.UM146_12980	Escherichia	1MUBM@1224,1RMUR@1236,3XMVV@561,COG1132@1,COG1132@2	NA|NA|NA	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
b0915	316407.4062487	6.9e-189	666.4	Escherichia	lpxK	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005			iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985	Escherichia	1MU8G@1224,1RMMW@1236,3XP9T@561,COG1663@1,COG1663@2	NA|NA|NA	I	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
b0916	316407.4062488	2.9e-245	854.0	Escherichia	ycaQ			ko:K09927					ko00000				Escherichia	1N40B@1224,1RPYB@1236,3XN2G@561,COG3214@1,COG3214@2	NA|NA|NA	S	Winged helix DNA-binding domain
b0917	1440052.EAKF1_ch0540c	7.3e-28	129.0	Escherichia	ycaR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09791					ko00000				Escherichia	1N6Y2@1224,1SCFF@1236,3XPZS@561,COG2835@1,COG2835@2	NA|NA|NA	S	Belongs to the UPF0434 family
b0918	316407.1651444	5.5e-138	496.9	Escherichia	kdsB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008690,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0046872,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005			iAF1260.b0918,iB21_1397.B21_00929,iBWG_1329.BWG_0770,iECBD_1354.ECBD_2677,iECB_1328.ECB_00922,iECDH10B_1368.ECDH10B_0988,iECDH1ME8569_1439.ECDH1ME8569_0869,iECD_1391.ECD_00922,iETEC_1333.ETEC_0986,iEcDH1_1363.EcDH1_2725,iEcHS_1320.EcHS_A1025,iEcolC_1368.EcolC_2678,iJO1366.b0918,iJR904.b0918,iUMNK88_1353.UMNK88_1071,iY75_1357.Y75_RS04770	Escherichia	1MUUU@1224,1RMAE@1236,3XM2V@561,COG1212@1,COG1212@2	NA|NA|NA	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
b0919	155864.EDL933_1182	1e-175	622.5	Escherichia	ycbJ												Escherichia	1P7ZI@1224,1RRJJ@1236,3XM71@561,COG3173@1,COG3173@2	NA|NA|NA	S	Phosphotransferase enzyme family
b0920	155864.EDL933_1183	2.2e-145	521.5	Escherichia	ycbC	GO:0000270,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0030203,GO:0031224,GO:0042546,GO:0043164,GO:0043170,GO:0044085,GO:0044425,GO:0044464,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901564											Escherichia	1MVW8@1224,1RNZC@1236,3XN93@561,COG1434@1,COG1434@2	NA|NA|NA	S	Plays a critical role in the metabolism of the essential lipid carrier used for cell wall synthesis
b0921	316407.1651445	5e-150	537.0	Escherichia	smtA	GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097697,GO:0140098,GO:0140101,GO:1901360		ko:K06219					ko00000				Escherichia	1MY0S@1224,1RP69@1236,3XPFZ@561,COG2227@1,COG2227@2	NA|NA|NA	J	Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs
b0922	198214.SF0918	3.6e-249	867.1	Gammaproteobacteria													Escherichia	1N0D6@1224,1RN7P@1236,COG3006@1,COG3006@2	NA|NA|NA	D	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
b0923	481805.EcolC_2673	4.5e-126	457.2	Escherichia	mukE	GO:0005575,GO:0009295		ko:K03804					ko00000,ko03036				Escherichia	1MXYN@1224,1RRBE@1236,3XP1Z@561,COG3095@1,COG3095@2	NA|NA|NA	D	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
b0924	316407.1651448	0.0	2780.7	Escherichia	mukB	GO:0000166,GO:0000793,GO:0000796,GO:0000819,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006323,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008144,GO:0008150,GO:0009987,GO:0016043,GO:0017076,GO:0019001,GO:0022402,GO:0030261,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032991,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0051276,GO:0051301,GO:0071103,GO:0071840,GO:0097159,GO:0097367,GO:0098813,GO:1901265,GO:1901363		ko:K03632					ko00000,ko03036				Escherichia	1MUWM@1224,1RPFF@1236,3XMJT@561,COG3096@1,COG3096@2	NA|NA|NA	D	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
b0925	316407.4062492	0.0	1239.2	Escherichia	ycbB	GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0006508,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0019538,GO:0033554,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0050896,GO:0051716,GO:0070004,GO:0070008,GO:0070011,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901564		ko:K21470					ko00000,ko01002,ko01011				Escherichia	1MV14@1224,1RQR7@1236,3XP8Y@561,COG2989@1,COG2989@2	NA|NA|NA	M	cysteine-type carboxypeptidase activity
b0926	155864.EDL933_1189	3.3e-100	370.9	Escherichia	ycbK												Escherichia	1MWW2@1224,1RS5K@1236,3XNAB@561,COG3108@1,COG3108@2	NA|NA|NA	S	Bacterial protein of unknown function (DUF882)
b0927	316407.4062494	2.6e-128	464.5	Escherichia	ycbL	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615											Escherichia	1MUDN@1224,1RMMG@1236,3XNUF@561,COG0491@1,COG0491@2	NA|NA|NA	S	Type II glyoxalase, isozyme of GloB, that hydrolyzes (R)-S-lactoylglutathione to (R)-lactate and glutathione. Plays a minor contribution to methylglyoxal (MG) detoxification in E.coli, compared to GloB. The two isoenzymes have additive effects and ensure maximal MG degradation
b0928	316407.1651449	2e-227	794.7	Escherichia	aspC	GO:0003674,GO:0003824,GO:0004069,GO:0004838,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0033585,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0070279,GO:0070547,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	2.6.1.1	ko:K00813	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230		R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007			iSFxv_1172.SFxv_1000	Escherichia	1MUT0@1224,1RN02@1236,3XNR8@561,COG1448@1,COG1448@2	NA|NA|NA	E	L-aspartate:2-oxoglutarate aminotransferase activity
b0929	316407.1651450	3.3e-208	730.7	Escherichia	ompF	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006855,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009279,GO:0009987,GO:0015031,GO:0015075,GO:0015238,GO:0015267,GO:0015288,GO:0015318,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0016043,GO:0019867,GO:0019904,GO:0022607,GO:0022803,GO:0022804,GO:0022829,GO:0022838,GO:0022857,GO:0022884,GO:0022885,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0033036,GO:0034220,GO:0034702,GO:0042221,GO:0042493,GO:0042802,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042912,GO:0043213,GO:0043933,GO:0044085,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0046930,GO:0047485,GO:0050896,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070206,GO:0070207,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0097718,GO:0098796,GO:1902495,GO:1904680,GO:1990351		ko:K09476	ko01501,ko02020,map01501,map02020	M00746			ko00000,ko00001,ko00002,ko01504,ko02000	1.B.1.1.1		iECH74115_1262.ECH74115_1090,iECSP_1301.ECSP_1034,iECs_1301.ECs1012,iG2583_1286.G2583_1164,iZ_1308.Z1276	Escherichia	1MVRY@1224,1RNBS@1236,3XPDU@561,COG3203@1,COG3203@2	NA|NA|NA	M	Belongs to the Gram-negative porin family
b0930	198214.SF0927	8.4e-273	945.7	Gammaproteobacteria													Escherichia	1MWFV@1224,1RMU4@1236,COG0017@1,COG0017@2	NA|NA|NA	J	Asparaginyl-tRNA synthetase
b0931	316407.1651456	3.5e-235	820.5	Escherichia	pncB	GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009266,GO:0009408,GO:0009435,GO:0009628,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100		R01724	RC00033	ko00000,ko00001,ko01000			iAF1260.b0931,iBWG_1329.BWG_0783,iECDH10B_1368.ECDH10B_1001,iECDH1ME8569_1439.ECDH1ME8569_0882,iECIAI39_1322.ECIAI39_2216,iETEC_1333.ETEC_0999,iEcDH1_1363.EcDH1_2712,iEcSMS35_1347.EcSMS35_2189,iJO1366.b0931,iJR904.b0931,iUMNK88_1353.UMNK88_1085,iY75_1357.Y75_RS04840	Escherichia	1MV8U@1224,1RQWS@1236,3XNP1@561,COG1488@1,COG1488@2	NA|NA|NA	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
b0932	316407.4062498	0.0	1762.3	Escherichia	pepN	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002			iECIAI1_1343.ECIAI1_0973,iECO103_1326.ECO103_0977,iECP_1309.ECP_0944,iECSE_1348.ECSE_0993,iECW_1372.ECW_m1042,iEKO11_1354.EKO11_2898,iWFL_1372.ECW_m1042	Escherichia	1MUCI@1224,1RMA7@1236,3XM5I@561,COG0308@1,COG0308@2	NA|NA|NA	E	Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation
b0933	155864.EDL933_1197	5.3e-136	490.3	Escherichia	ssuB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K15555	ko00920,ko02010,map00920,map02010	M00436			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.2			Escherichia	1MUKI@1224,1RP0J@1236,3XRIM@561,COG1116@1,COG1116@2	NA|NA|NA	P	Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system
b0934	316407.85674791	4.6e-135	487.3	Escherichia	ssuC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K15554	ko00920,ko02010,map00920,map02010	M00436			ko00000,ko00001,ko00002,ko02000	3.A.1.17.2		iAF1260.b0934,iB21_1397.B21_00945,iBWG_1329.BWG_0786,iEC55989_1330.EC55989_0983,iECBD_1354.ECBD_2661,iECB_1328.ECB_00938,iECDH10B_1368.ECDH10B_1004,iECDH1ME8569_1439.ECDH1ME8569_0885,iECD_1391.ECD_00938,iECIAI1_1343.ECIAI1_0975,iECNA114_1301.ECNA114_1020,iECO103_1326.ECO103_0979,iECO26_1355.ECO26_1061,iECSF_1327.ECSF_0855,iECW_1372.ECW_m1044,iEKO11_1354.EKO11_2896,iETEC_1333.ETEC_1002,iEcDH1_1363.EcDH1_2709,iEcE24377_1341.EcE24377A_1036,iEcHS_1320.EcHS_A1043,iEcolC_1368.EcolC_2662,iJO1366.b0934,iSSON_1240.SSON_0937,iUMNK88_1353.UMNK88_1089,iWFL_1372.ECW_m1044,iY75_1357.Y75_RS04855	Escherichia	1MWS0@1224,1RR15@1236,3XPXV@561,COG0600@1,COG0600@2	NA|NA|NA	P	aliphatic sulfonates transport permease protein ssuC
b0935	316407.4062503	3.7e-218	763.8	Escherichia	ssuD	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0005515,GO:0006082,GO:0006790,GO:0006950,GO:0008150,GO:0008152,GO:0008726,GO:0009056,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016054,GO:0016491,GO:0016705,GO:0016712,GO:0019694,GO:0042802,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0046306,GO:0050896,GO:0055114,GO:0071704,GO:1901575	1.14.14.5	ko:K04091	ko00920,map00920		R07210,R10206	RC01779,RC02556	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_2212	Escherichia	1MWMV@1224,1RP4Z@1236,3XQSB@561,COG2141@1,COG2141@2	NA|NA|NA	C	Belongs to the SsuD family
b0936	316407.85674792	2.9e-176	624.4	Escherichia	ssuA	GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0044237		ko:K15553	ko00920,ko02010,map00920,map02010	M00436			ko00000,ko00001,ko00002,ko02000	3.A.1.17.2		iAF1260.b0936,iBWG_1329.BWG_0788,iECDH10B_1368.ECDH10B_1006,iECDH1ME8569_1439.ECDH1ME8569_0887,iECSF_1327.ECSF_0857,iETEC_1333.ETEC_1004,iEcDH1_1363.EcDH1_2707,iJO1366.b0936,iY75_1357.Y75_RS04865	Escherichia	1MV9S@1224,1RQJK@1236,3XQ8C@561,COG0715@1,COG0715@2	NA|NA|NA	P	aliphatic sulfonates
b0937	316407.4062505	2e-103	381.7	Escherichia	ssuE	GO:0003674,GO:0003824,GO:0006082,GO:0006790,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008752,GO:0009056,GO:0009267,GO:0009605,GO:0009970,GO:0009987,GO:0009991,GO:0016043,GO:0016054,GO:0016491,GO:0016645,GO:0016646,GO:0019694,GO:0022607,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0046306,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055114,GO:0065003,GO:0071496,GO:0071704,GO:0071840,GO:1901575	1.5.1.38	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100		R05706,R07210,R10206	RC00126,RC01779,RC02556	ko00000,ko00001,ko01000			iAF1260.b0937,iB21_1397.B21_00948,iBWG_1329.BWG_0789,iE2348C_1286.E2348C_0930,iECBD_1354.ECBD_2658,iECB_1328.ECB_00941,iECDH10B_1368.ECDH10B_1007,iECDH1ME8569_1439.ECDH1ME8569_0888,iECD_1391.ECD_00941,iECIAI1_1343.ECIAI1_0978,iECO103_1326.ECO103_0982,iECW_1372.ECW_m1047,iEKO11_1354.EKO11_2893,iETEC_1333.ETEC_1005,iEcDH1_1363.EcDH1_2706,iEcE24377_1341.EcE24377A_1052,iEcHS_1320.EcHS_A1046,iEcolC_1368.EcolC_2659,iJO1366.b0937,iSbBS512_1146.SbBS512_E2381,iUMNK88_1353.UMNK88_1092,iWFL_1372.ECW_m1047,iY75_1357.Y75_RS04870	Escherichia	1MX40@1224,1RQGZ@1236,3XMDI@561,COG0431@1,COG0431@2	NA|NA|NA	S	Catalyzes an NADPH-dependent reduction of FMN, but is also able to reduce FAD or riboflavin
b0938	316407.85674793	3.1e-90	337.8	Gammaproteobacteria													Escherichia	1RFEW@1224,1S5AF@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial
b0939	316407.4062507	8.3e-128	463.0	Gammaproteobacteria													Escherichia	1NSWH@1224,1SN1W@1236,COG3121@1,COG3121@2	NA|NA|NA	NU	Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae
b0940	316407.4062508	0.0	1732.6	Escherichia	elfC	GO:0003674,GO:0005215,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008201,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043167,GO:0043168,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944,GO:0097367,GO:1901681		ko:K07347	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Escherichia	1MUHE@1224,1RMPU@1236,3XNQM@561,COG3188@1,COG3188@2	NA|NA|NA	NU	Could be involved in the export and assembly of the ElfA fimbrial subunits across the outer membrane
b0941	316407.4062509	2.1e-207	728.0	Gammaproteobacteria													Escherichia	1R6MJ@1224,1S13V@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces
b0942	316407.4062510	1.2e-94	352.4	Gammaproteobacteria													Escherichia	1RBMU@1224,1S31S@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces
b0943	316407.85674794	5.4e-92	343.6	Gammaproteobacteria													Escherichia	1N3AG@1224,1SBD7@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial
b0944	316407.85674795	1.1e-130	472.6	Gammaproteobacteria													Escherichia	1RAQF@1224,1S585@1236,COG3121@1,COG3121@2	NA|NA|NA	NU	chaperone
b0945	155864.EDL933_1211	8.9e-192	676.0	Escherichia	pyrD	GO:0000166,GO:0003674,GO:0003824,GO:0004152,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0010181,GO:0016020,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0032553,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0048037,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_1029,iECIAI39_1322.ECIAI39_2202,iECUMN_1333.ECUMN_1134,iEcSMS35_1347.EcSMS35_2174	Escherichia	1MU7C@1224,1RMCP@1236,3XNCA@561,COG0167@1,COG0167@2	NA|NA|NA	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor
b0946	316407.85674796	7.9e-102	376.3	Escherichia	zapC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0032153,GO:0042802,GO:0044464,GO:0050789,GO:0050794,GO:0051302,GO:0065007		ko:K18657					ko00000,ko03036				Escherichia	1N1DT@1224,1RYK3@1236,28I7M@1,2Z8AH@2,3XM3S@561	NA|NA|NA	D	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ
b0947	316407.85674797	3.4e-216	757.3	Escherichia	ycbX	GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0044237,GO:0044248,GO:0050896,GO:0098754		ko:K07140					ko00000				Escherichia	1MXN2@1224,1RMN7@1236,3XM6S@561,COG0633@1,COG0633@2,COG3217@1,COG3217@2	NA|NA|NA	C	toxin catabolic process
b0948	316407.4062515	0.0	1429.1	Escherichia	rlmL	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.173,2.1.1.264	ko:K12297			R07234	RC00003	ko00000,ko01000,ko03009				Escherichia	1MUQM@1224,1RNMH@1236,3XNPW@561,COG0116@1,COG0116@2,COG1092@1,COG1092@2	NA|NA|NA	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
b0949	316407.4062519	0.0	1145.2	Escherichia	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363		ko:K15738					ko00000,ko02000	3.A.1.120.6			Escherichia	1MU37@1224,1RPCU@1236,3XPE2@561,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter, ATP-binding protein
b0950	198214.SF0951	1.3e-235	822.0	Gammaproteobacteria													Escherichia	1MWG1@1224,1RM9Z@1236,COG2995@1,COG2995@2	NA|NA|NA	S	paraquat-inducible protein A
b0951	316407.1651463	4.5e-311	1073.2	Escherichia	pqiB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0016043,GO:0030288,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044464,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071840,GO:0120009		ko:K06192					ko00000				Escherichia	1MU1T@1224,1RN89@1236,3XN55@561,COG1463@1,COG1463@2,COG3008@1,COG3008@2	NA|NA|NA	Q	Paraquat-inducible protein B
b0952	198214.SF0953	1.5e-103	382.1	Gammaproteobacteria													Escherichia	1PJIN@1224,1RQTB@1236,COG3009@1,COG3009@2	NA|NA|NA	S	protein conserved in bacteria
b0953	1440052.EAKF1_ch0513c	1e-23	115.2	Gammaproteobacteria													Escherichia	1N761@1224,1SCIC@1236,COG3130@1,COG3130@2	NA|NA|NA	J	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes)
b0954	155864.EDL933_1221	4.3e-97	360.5	Escherichia	fabA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019171,GO:0019752,GO:0032787,GO:0034017,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004			iAF1260.b0954,iB21_1397.B21_00965,iBWG_1329.BWG_0806,iE2348C_1286.E2348C_0940,iEC042_1314.EC042_1039,iECBD_1354.ECBD_2641,iECB_1328.ECB_00958,iECDH10B_1368.ECDH10B_1024,iECD_1391.ECD_00958,iECED1_1282.ECED1_0977,iECH74115_1262.ECH74115_1118,iECIAI1_1343.ECIAI1_0995,iECIAI39_1322.ECIAI39_2193,iECNA114_1301.ECNA114_1032,iECO103_1326.ECO103_1000,iECO111_1330.ECO111_1022,iECO26_1355.ECO26_1081,iECOK1_1307.ECOK1_1013,iECS88_1305.ECS88_0975,iECSF_1327.ECSF_0868,iECSP_1301.ECSP_1060,iECUMN_1333.ECUMN_1143,iECW_1372.ECW_m1064,iECs_1301.ECs1038,iEKO11_1354.EKO11_2876,iETEC_1333.ETEC_1024,iEcE24377_1341.EcE24377A_1068,iEcHS_1320.EcHS_A1063,iEcSMS35_1347.EcSMS35_2166,iEcolC_1368.EcolC_2642,iG2583_1286.G2583_1189,iJO1366.b0954,iJR904.b0954,iLF82_1304.LF82_0604,iSBO_1134.SBO_2277,iSDY_1059.SDY_0927,iSF_1195.SF0954,iSSON_1240.SSON_0958,iSbBS512_1146.SbBS512_E2362,iUMNK88_1353.UMNK88_1108,iWFL_1372.ECW_m1064,iY75_1357.Y75_RS04955,iZ_1308.Z1304,ic_1306.c1090	Escherichia	1MWV8@1224,1RP6W@1236,3XMG8@561,COG0764@1,COG0764@2	NA|NA|NA	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length
b0955	316407.85674799	0.0	1176.0	Escherichia	ycbZ			ko:K04770					ko00000,ko01000,ko01002				Escherichia	1MWGB@1224,1RMPC@1236,3XNXW@561,COG1067@1,COG1067@2	NA|NA|NA	O	Belongs to the peptidase S16 family
b0956	155864.EDL933_1223	1.9e-77	295.0	Escherichia	matP	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0032991,GO:0032993,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0051276,GO:0051301,GO:0071840,GO:0097047,GO:0097159,GO:1901363		ko:K09911					ko00000				Escherichia	1RA57@1224,1S28S@1236,3XMGH@561,COG3120@1,COG3120@2	NA|NA|NA	D	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain
b0957	155864.EDL933_1224	2.3e-190	671.4	Escherichia	ompA	GO:0000746,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009597,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0015267,GO:0015288,GO:0016020,GO:0016021,GO:0016032,GO:0019058,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030260,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0033554,GO:0034220,GO:0042802,GO:0043207,GO:0044403,GO:0044409,GO:0044419,GO:0044425,GO:0044462,GO:0044464,GO:0044764,GO:0046718,GO:0046930,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051806,GO:0051828,GO:0055085,GO:0071944,GO:0098796		ko:K03286					ko00000,ko02000	1.B.6		iECIAI1_1343.ECIAI1_0998,iECNA114_1301.ECNA114_1035,iECSF_1327.ECSF_0871,iUTI89_1310.UTI89_C1022	Escherichia	1N6EM@1224,1RMJ7@1236,3XMXT@561,COG2885@1,COG2885@2,COG3637@1,COG3637@2	NA|NA|NA	M	Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes
b0958	155864.EDL933_1225	1.5e-86	325.5	Escherichia	sulA	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0010564,GO:0010948,GO:0031333,GO:0031668,GO:0032271,GO:0032272,GO:0032465,GO:0032466,GO:0033554,GO:0034260,GO:0043086,GO:0043087,GO:0043254,GO:0044087,GO:0044092,GO:0045786,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051302,GO:0051336,GO:0051346,GO:0051716,GO:0051726,GO:0051782,GO:0065007,GO:0065009,GO:0071496,GO:1903664,GO:1903665,GO:2000241,GO:2000242,GO:2000244,GO:2000245		ko:K13053					ko00000,ko03036				Escherichia	1RD22@1224,1RYWE@1236,3XMSR@561,COG5404@1,COG5404@2	NA|NA|NA	D	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
b0959	316407.4062523	1e-113	416.0	Escherichia	sxy	GO:0006355,GO:0006810,GO:0008150,GO:0009290,GO:0009292,GO:0009294,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015931,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031344,GO:0031346,GO:0044087,GO:0044089,GO:0044093,GO:0044764,GO:0048518,GO:0048522,GO:0050657,GO:0050789,GO:0050794,GO:0051027,GO:0051090,GO:0051091,GO:0051128,GO:0051130,GO:0051171,GO:0051179,GO:0051234,GO:0051252,GO:0051704,GO:0060255,GO:0060491,GO:0065007,GO:0065009,GO:0071702,GO:0071705,GO:0080090,GO:0098657,GO:1903506,GO:1903656,GO:1903658,GO:2000112,GO:2001141		ko:K07343					ko00000				Escherichia	1RDWD@1224,1S496@1236,3XN76@561,COG3070@1,COG3070@2	NA|NA|NA	K	Induces low levels of natural DNA uptake by inducing transcription of the competence genes (the CRP-S regulon) required for DNA transformation. Induction of the CRP-S regulon also requires Sxy-activated promoter (CRP-S), cAMP receptor protein (CRP) and cAMP. Induces CRP-S site-containing genes which are involved in genome maintenance and transcription or encoding transposases and toxin-antitoxin pairs
b0960	316407.85674800	0.0	1422.1	Escherichia	yccS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MWR1@1224,1RNIJ@1236,3XMFN@561,COG1289@1,COG1289@2	NA|NA|NA	S	FUSC-like inner membrane protein yccS
b0961	198214.SF0963	6.1e-76	290.0	Gammaproteobacteria													Escherichia	1RA96@1224,1S1ZC@1236,COG3304@1,COG3304@2	NA|NA|NA	S	Membrane
b0962	316407.1651471	0.0	1375.5	Escherichia	helD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1902494	3.6.4.12	ko:K03658					ko00000,ko01000,ko03400				Escherichia	1MVWI@1224,1RN1N@1236,3XP55@561,COG0210@1,COG0210@2	NA|NA|NA	L	Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP
b0963	155864.EDL933_1230	1.2e-82	312.4	Escherichia	mgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120		R01016	RC00424	ko00000,ko00001,ko01000			iECUMN_1333.ECUMN_1153	Escherichia	1RD3D@1224,1S3XN@1236,3XN43@561,COG1803@1,COG1803@2	NA|NA|NA	G	methylglyoxal synthase activity
b0964	155864.EDL933_1231	8.9e-116	422.9	Escherichia	yccT			ko:K09909					ko00000				Escherichia	1RK33@1224,1RZRX@1236,3XNYU@561,COG3110@1,COG3110@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2057)
b0965	316407.85674802	3.2e-71	274.2	Escherichia	yccU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K06929					ko00000				Escherichia	1N03D@1224,1S3T2@1236,3XPIE@561,COG1832@1,COG1832@2	NA|NA|NA	S	cofactor binding
b0966	1440052.EAKF1_ch0500	1.5e-52	211.8	Escherichia	hspQ			ko:K11940					ko00000,ko03036				Escherichia	1RGWN@1224,1S62D@1236,3XPQ5@561,COG3785@1,COG3785@2	NA|NA|NA	S	Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress
b0967	469008.B21_00978	7e-228	796.2	Escherichia	rlmI	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.191	ko:K06969					ko00000,ko01000,ko03009				Escherichia	1MUGB@1224,1RN7Z@1236,3XPG1@561,COG1092@1,COG1092@2	NA|NA|NA	J	Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA
b0968	155864.EDL933_1236	4.8e-47	193.4	Escherichia	yccX	GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120		R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000				Escherichia	1N6NU@1224,1SCPF@1236,3XPZE@561,COG1254@1,COG1254@2	NA|NA|NA	C	acylphosphatase activity
b0969	155864.EDL933_1237	2.3e-56	224.6	Escherichia	tusE	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360		ko:K11179	ko04122,map04122				ko00000,ko00001,ko01000,ko03016				Escherichia	1RGVG@1224,1S5ZA@1236,3XPQI@561,COG2920@1,COG2920@2	NA|NA|NA	J	Part of a sulfur-relay system
b0970	199310.c1110	8.1e-109	399.8	Escherichia	yccA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016021,GO:0019222,GO:0030162,GO:0031224,GO:0044425,GO:0044464,GO:0050789,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071944,GO:0080090		ko:K19416		M00742			ko00000,ko00002,ko02000	1.A.14.2.1			Escherichia	1MU69@1224,1RRVZ@1236,3XNC8@561,COG0670@1,COG0670@2	NA|NA|NA	S	Belongs to the BI1 family
b0972	199310.c1113	2.3e-220	771.2	Escherichia	hyaA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120		R08034	RC00250	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_76,iUTI89_1310.UTI89_C1040	Escherichia	1MWAC@1224,1RNTJ@1236,3XM4G@561,COG1740@1,COG1740@2	NA|NA|NA	C	This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth
b0973	198214.SF0974	0.0	1260.7	Gammaproteobacteria													Escherichia	1MWFJ@1224,1RMC3@1236,COG0374@1,COG0374@2	NA|NA|NA	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family
b0974	155864.EDL933_1312	6.4e-136	490.0	Escherichia	hyaC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494		ko:K03620	ko02020,map02020				ko00000,ko00001				Escherichia	1MU87@1224,1RNTH@1236,3XN5T@561,COG1969@1,COG1969@2	NA|NA|NA	C	Ni Fe-hydrogenase 1 B-type cytochrome subunit
b0975	316407.1651476	2.3e-107	394.8	Escherichia	hyaD	GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564		ko:K03605					ko00000,ko01000,ko01002				Escherichia	1RE1C@1224,1S1V0@1236,3XRHU@561,COG0680@1,COG0680@2	NA|NA|NA	O	Protease involved in the C-terminal processing of HyaB, the large subunit of hydrogenase 1
b0976	316407.1651477	3.3e-73	280.8	Escherichia	hyaE	GO:0003674,GO:0005048,GO:0005488,GO:0033218,GO:0042277		ko:K03619					ko00000				Escherichia	1RKWY@1224,1S7Q1@1236,3XPRY@561,COG1999@1,COG1999@2	NA|NA|NA	S	Hydrogenase-1 operon protein HyaE
b0977	316407.1651478	1e-164	585.9	Escherichia	hyaF			ko:K03618					ko00000				Escherichia	1MV2U@1224,1S2ZY@1236,3XNHN@561,COG1773@1,COG1773@2	NA|NA|NA	C	Hydrogenase-1 operon protein hyaF
b0978	316407.1651479	2.7e-296	1023.8	Escherichia	appC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0022900,GO:0022904,GO:0032991,GO:0044237,GO:0044464,GO:0045333,GO:0055114,GO:0070069,GO:0071944	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3		iSBO_1134.SBO_2253,iSbBS512_1146.SbBS512_E2337	Escherichia	1MV60@1224,1RN2U@1236,3XNZW@561,COG1271@1,COG1271@2	NA|NA|NA	C	oxidase, subunit
b0979	316407.1651480	7.2e-214	749.6	Escherichia	appB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0022900,GO:0022904,GO:0032991,GO:0044237,GO:0044464,GO:0045333,GO:0055114,GO:0070069,GO:0071944	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3		iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,ic_1306.c1120	Escherichia	1MURP@1224,1RYU0@1236,3XNHS@561,COG1294@1,COG1294@2	NA|NA|NA	C	oxidase, subunit
b0980	316407.1651481	1.2e-249	868.6	Escherichia	appA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005975,GO:0006066,GO:0006793,GO:0006796,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008252,GO:0009056,GO:0009267,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016036,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019203,GO:0019637,GO:0019751,GO:0030288,GO:0030313,GO:0031667,GO:0031668,GO:0031669,GO:0031975,GO:0033517,GO:0033518,GO:0033554,GO:0034059,GO:0036293,GO:0036294,GO:0042221,GO:0042578,GO:0042594,GO:0042597,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044464,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050308,GO:0050896,GO:0051716,GO:0052745,GO:0070482,GO:0070887,GO:0071453,GO:0071454,GO:0071496,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.2,3.1.3.26	ko:K01093	ko00562,ko00740,ko01100,map00562,map00740,map01100		R00548,R03372	RC00017,RC00078	ko00000,ko00001,ko01000			iEC042_1314.EC042_1065,iECABU_c1320.ECABU_c10140,iECSE_1348.ECSE_1042,iECW_1372.ECW_m1091,iEKO11_1354.EKO11_2850,iLF82_1304.LF82_0100,iNRG857_1313.NRG857_04465,iWFL_1372.ECW_m1091	Escherichia	1NR0Z@1224,1RYQE@1236,2DB79@1,2Z7K9@2,3XNWR@561	NA|NA|NA	S	myo-inositol hexakisphosphate dephosphorylation
b0981	316407.4062541	0.0	1354.0	Escherichia	etk	GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0031224,GO:0036211,GO:0038083,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0046777,GO:0071704,GO:0071944,GO:0140096,GO:1901564		ko:K16692					ko00000,ko01000,ko01001				Escherichia	1MVI9@1224,1RNB0@1236,3XN7H@561,COG0489@1,COG0489@2,COG3206@1,COG3206@2	NA|NA|NA	DM	Tyrosine-protein kinase
b0982	155864.EDL933_1320	3.8e-78	297.4	Escherichia	etp	GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	3.1.3.48	ko:K01104					ko00000,ko01000				Escherichia	1N0DZ@1224,1S92S@1236,3XPM0@561,COG0394@1,COG0394@2	NA|NA|NA	T	low molecular weight
b0983	155864.EDL933_1321	1.1e-214	752.3	Escherichia	gfcE			ko:K01991	ko02026,map02026				ko00000,ko00001,ko02000	1.B.18			Escherichia	1N7GP@1224,1RQSM@1236,3XNQG@561,COG1596@1,COG1596@2	NA|NA|NA	M	polysaccharide export protein
b0984	316407.4062544	0.0	1445.6	Escherichia	gfcD												Escherichia	1MX3H@1224,1RQKV@1236,3XMA1@561,COG4775@1,COG4775@2	NA|NA|NA	M	extracellular polysaccharide metabolic process
b0985	316407.85674809	7.7e-140	503.1	Escherichia	gfcC												Escherichia	1NG4X@1224,1RZ19@1236,29T7B@1,30EE4@2,3XM59@561	NA|NA|NA	S	Capsule biosynthesis GfcC
b0986	316407.4062546	2.7e-117	427.9	Escherichia	gfcB												Escherichia	1N1VT@1224,1RMP6@1236,28M8B@1,2ZAMG@2,3XNZQ@561	NA|NA|NA	M	extracellular polysaccharide metabolic process
b4516	1443113.LC20_03235	9e-46	189.1	Yersinia													Escherichia	1N3Y7@1224,1SC0J@1236,41HER@629,COG3677@1,COG3677@2	NA|NA|NA	L	id in 91 aa, and to Shigella dysenteriae insertion element IS1 protein InsA TR
b0988	316407.1651483	1.5e-94	352.1	Escherichia	insB4	GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K07480					ko00000				Escherichia	1NHAK@1224,1RQRY@1236,3XREY@561,COG1662@1,COG1662@2	NA|NA|NA	L	Absolutely required for transposition of IS1
b0989	155864.EDL933_1326	1.1e-32	145.2	Escherichia	cspH			ko:K03704					ko00000,ko03000				Escherichia	1NCMX@1224,1SDQS@1236,3XQ1Z@561,COG1278@1,COG1278@2	NA|NA|NA	K	Cold shock-like protein
b0990	155864.EDL933_1327	5.1e-33	146.4	Escherichia	cspG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0044424,GO:0044444,GO:0044464,GO:0050896		ko:K03704					ko00000,ko03000				Escherichia	1N6Q5@1224,1SCA7@1236,3XQ0H@561,COG1278@1,COG1278@2	NA|NA|NA	K	nucleic acid-templated transcription
b4723	362663.ECP_0988	2.5e-31	140.6	Gammaproteobacteria													Escherichia	1P6C3@1224,1ST99@1236,28YUP@1,2ZKMW@2	NA|NA|NA		
b0991	199310.c1124	8.3e-37	159.1	Gammaproteobacteria													Escherichia	1NZ83@1224,1SR0H@1236,2F76F@1,33ZMW@2	NA|NA|NA	S	Putative antitoxin of bacterial toxin-antitoxin system
b4517	199310.c1125	2.8e-21	107.1	Escherichia	gnsA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464											Escherichia	1NEUJ@1224,1SFD3@1236,2BVP3@1,332DR@2,3XQ2P@561	NA|NA|NA	S	Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation
b0992	316407.4062709	3.4e-205	720.7	Escherichia	yccM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MY5M@1224,1RNSU@1236,3XP2W@561,COG0348@1,COG0348@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
b0993	316407.85674812	0.0	1691.8	Escherichia	torS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0010033,GO:0015980,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045333,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07647	ko02020,map02020	M00455			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1NRP8@1224,1SKTW@1236,3XMSI@561,COG0642@1,COG0784@1,COG0784@2,COG2198@1,COG2198@2,COG2205@2	NA|NA|NA	T	PhoQ Sensor
b0994	316407.4062711	3.7e-193	680.6	Escherichia	torT	GO:0005575,GO:0005623,GO:0042597,GO:0044464		ko:K11930					ko00000				Escherichia	1MXQN@1224,1S0HG@1236,3XPG5@561,COG1879@1,COG1879@2	NA|NA|NA	G	inducer it probably interacts with TorS and allows it to play a role in the induction of the torCAD operon for trimethylamine N-oxide reductase
b0995	316407.1651487	1.7e-125	455.3	Escherichia	torR	GO:0000156,GO:0000160,GO:0003674,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K07772	ko02020,map02020	M00455			ko00000,ko00001,ko00002,ko02022				Escherichia	1MWJG@1224,1RPU3@1236,3XM4X@561,COG0745@1,COG0745@2	NA|NA|NA	K	Member of the two-component regulatory system TorS TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Phosphorylated TorR activates the transcription of the torCAD operon by binding to four decameric boxes located in the torCAD promoter. Box1, 2 and 4 contain the DNA sequence 5'- CTGTTCATAT-3' and box3 contains the DNA sequence 5'-CCGTTCATCC-3'. Phosphorylated as well as unphosphorylated TorR negatively regulates its own expression by binding to box1 and 2
b0996	316407.1651488	1.4e-228	798.5	Escherichia	torC	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0020037,GO:0022900,GO:0031224,GO:0032991,GO:0044237,GO:0044425,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494,GO:1990204		ko:K03532	ko02020,map02020				ko00000,ko00001,ko02000	5.A.3.4		iEC042_1314.EC042_1072,iUTI89_1310.UTI89_C1060,ic_1306.c1132	Escherichia	1MWV2@1224,1RQ52@1236,3XQEX@561,COG3005@1,COG3005@2	NA|NA|NA	C	Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorA. Acts by transferring electrons from the membranous menaquinones to TorA. This transfer probably involves an electron transfer pathway from menaquinones to the N-terminal domain of TorC, then from the N-terminus to the C-terminus, and finally to TorA. TorC apocytochrome negatively autoregulates the torCAD operon probably by inhibiting the TorS kinase activity
b0997	316407.1651489	0.0	1721.1	Escherichia	torA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0030151,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0050626,GO:0055114	1.7.2.3	ko:K07811	ko02020,map02020				ko00000,ko00001,ko01000,ko02000	5.A.3.4		iEC042_1314.EC042_1073	Escherichia	1NR6J@1224,1RMVE@1236,3XPC8@561,COG0243@1,COG0243@2	NA|NA|NA	C	an anaerobic reaction coupled to energy-yielding reactions
b0998	316407.1651490	2.1e-108	398.3	Escherichia	torD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043170,GO:0043546,GO:0044238,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0051604,GO:0071704,GO:0097159,GO:1901363,GO:1901564		ko:K03533	ko02020,map02020				ko00000,ko00001,ko02000	5.A.3.4			Escherichia	1RJ3Z@1224,1S31G@1236,3XNXG@561,COG3381@1,COG3381@2	NA|NA|NA	O	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor
b0999	155864.EDL933_1337	3.9e-50	203.8	Escherichia	cbpM	GO:0003674,GO:0004857,GO:0008150,GO:0030234,GO:0043086,GO:0044092,GO:0050790,GO:0065007,GO:0065009,GO:0098772		ko:K18997					ko00000,ko03036				Escherichia	1N0AR@1224,1S9HZ@1236,3XPNV@561,COG0789@1,COG0789@2	NA|NA|NA	K	Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ
b1000	316407.1651491	5.3e-175	620.2	Escherichia	cbpA	GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0005488,GO:0097159,GO:1901363		ko:K05516					ko00000,ko03036,ko03110				Escherichia	1MUZ4@1224,1RP09@1236,3XNMP@561,COG0484@1,COG0484@2	NA|NA|NA	O	displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity
b1001	316407.4062556	1.8e-242	844.7	Escherichia	yccE												Escherichia	1NRMN@1224,1SMDS@1236,2EWX4@1,33Q8G@2,3XR9Z@561	NA|NA|NA		
b1002	316407.1651498	6.4e-240	836.3	Escherichia	agp	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008877,GO:0009056,GO:0009987,GO:0016052,GO:0016158,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019320,GO:0030288,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0046365,GO:0050308,GO:0071704,GO:1901575	3.1.3.10	ko:K01085	ko00010,ko01120,map00010,map01120		R00947	RC00078	ko00000,ko00001,ko01000			iECO111_1330.ECO111_1113,iECO26_1355.ECO26_1557	Escherichia	1NR0Z@1224,1RQ9G@1236,2DB79@1,2Z7K9@2,3XP1X@561	NA|NA|NA	S	glucose-1-phosphatase
b1003	155864.EDL933_1343	9.1e-36	155.6	Escherichia	yccJ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N16W@1224,1S9Z8@1236,2CE55@1,32RZ6@2,3XQ0S@561	NA|NA|NA	S	YccJ-like protein
b1004	198214.SF1008	2e-106	391.7	Gammaproteobacteria													Escherichia	1MW7N@1224,1S23B@1236,COG0655@1,COG0655@2	NA|NA|NA	S	Belongs to the WrbA family
b1006	316407.4062560	1.7e-235	821.6	Escherichia	rutG	GO:0003674,GO:0005215,GO:0005350,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0006810,GO:0006855,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0015205,GO:0015210,GO:0015238,GO:0015851,GO:0015855,GO:0015857,GO:0015893,GO:0016020,GO:0016021,GO:0017144,GO:0019860,GO:0022857,GO:0031224,GO:0031226,GO:0034641,GO:0042221,GO:0042493,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072527,GO:0072529,GO:0072531,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1903791,GO:1904082		ko:K09016					ko00000,ko02000	2.A.40.1.3		iECO103_1326.ECO103_1052,iECUMN_1333.ECUMN_1189	Escherichia	1MUN9@1224,1RRK5@1236,3XMK3@561,COG2233@1,COG2233@2	NA|NA|NA	F	permease
b1007	316407.85674814	2.3e-92	344.7	Gammaproteobacteria													Escherichia	1NESS@1224,1S00E@1236,COG1853@1,COG1853@2	NA|NA|NA	C	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway
b1008	316407.4062562	1.5e-109	402.1	Gammaproteobacteria													Escherichia	1R9VX@1224,1RNQE@1236,COG0778@1,COG0778@2	NA|NA|NA	C	May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted
b1009	316407.4062563	3.9e-150	537.3	Escherichia	rutD	GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0017144,GO:0019740,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575		ko:K09023	ko00240,ko01100,map00240,map01100		R09983	RC02769	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_1120,iECO26_1355.ECO26_1247,iECUMN_1333.ECUMN_1192,iSSON_1240.SSON_1027,ic_1306.c1146	Escherichia	1QVBR@1224,1T2BI@1236,3XRCZ@561,COG2021@1,COG2021@2	NA|NA|NA	F	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in
b1010	199310.c1147	4.5e-67	260.4	Gammaproteobacteria													Escherichia	1RD6W@1224,1S47V@1236,COG0251@1,COG0251@2	NA|NA|NA	J	May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation
b1011	316407.85674815	7.9e-131	473.0	Gammaproteobacteria													Escherichia	1MV0W@1224,1RP6J@1236,COG1335@1,COG1335@2	NA|NA|NA	Q	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2
b1012	316407.4062575	2.1e-221	774.6	Escherichia	rutA	GO:0003674,GO:0003824,GO:0004497,GO:0006139,GO:0006206,GO:0006208,GO:0006210,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0017144,GO:0019740,GO:0019859,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0052614,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.14.99.46	ko:K09018	ko00240,ko01100,map00240,map01100		R09936	RC02732	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_1123,iECUMN_1333.ECUMN_1195	Escherichia	1MXZH@1224,1RMB2@1236,3XQ6H@561,COG2141@1,COG2141@2	NA|NA|NA	F	Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate
b1013	198214.SF1016	3.1e-113	414.5	Gammaproteobacteria													Escherichia	1ND64@1224,1RS7A@1236,COG1309@1,COG1309@2	NA|NA|NA	K	transcriptional regulator
b1014	316407.1651503	0.0	2575.4	Escherichia	putA	GO:0000166,GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0003842,GO:0004657,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006355,GO:0006520,GO:0006536,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009889,GO:0009890,GO:0009892,GO:0009898,GO:0009987,GO:0010133,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016054,GO:0016491,GO:0016645,GO:0016646,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043565,GO:0043648,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0045892,GO:0045934,GO:0046395,GO:0046483,GO:0046700,GO:0048037,GO:0048519,GO:0048523,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:0098552,GO:0098562,GO:0140110,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130		R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000			iSbBS512_1146.SbBS512_E2304	Escherichia	1MV93@1224,1RN48@1236,3XMSS@561,COG0506@1,COG0506@2,COG3905@1,COG3905@2,COG4230@1,COG4230@2	NA|NA|NA	K	Oxidizes proline to glutamate for use as a carbon and nitrogen source
b1015	316407.1651504	8.4e-279	965.7	Escherichia	putP	GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005298,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006865,GO:0006869,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0010876,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015718,GO:0015804,GO:0015824,GO:0015849,GO:0015908,GO:0015912,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0033036,GO:0034220,GO:0035725,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039		ko:K11928					ko00000,ko02000	2.A.21.2		iSbBS512_1146.SbBS512_E2302	Escherichia	1MUBI@1224,1RMXU@1236,3XNW6@561,COG0591@1,COG0591@2	NA|NA|NA	P	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
b1018	198214.SF1020	4.5e-208	730.3	Gammaproteobacteria													Escherichia	1MWFR@1224,1RNWE@1236,COG2822@1,COG2822@2	NA|NA|NA	P	periplasmic lipoprotein involved in iron transport
b1019	316407.4062584	2.9e-248	864.0	Escherichia	efeB			ko:K16301					ko00000,ko01000,ko02000	2.A.108.2.3			Escherichia	1MUEE@1224,1RNXN@1236,3XMXM@561,COG2837@1,COG2837@2	NA|NA|NA	P	Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact
b1020	155864.EDL933_1447	4.2e-200	703.7	Escherichia	phoH	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K06217					ko00000				Escherichia	1PNF2@1224,1RNZ7@1236,3XMBE@561,COG1702@1,COG1702@2	NA|NA|NA	T	Phosphate starvation-inducible protein
b1021	316407.4062585	2.8e-67	261.2	Escherichia	pgaD	GO:0005575,GO:0005623,GO:0005886,GO:0007155,GO:0008150,GO:0009987,GO:0016020,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0044464,GO:0044764,GO:0051704,GO:0071944,GO:0090605		ko:K11937	ko02026,map02026				ko00000,ko00001				Escherichia	1NC08@1224,1SECV@1236,2EENA@1,338G7@2,3XR68@561	NA|NA|NA	S	PgaD-like protein
b1022	316407.4062586	5e-251	873.2	Escherichia	pgaC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0007155,GO:0008150,GO:0008194,GO:0008375,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0044464,GO:0044764,GO:0051704,GO:0071944,GO:0090605		ko:K11936	ko02026,map02026				ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3	GT2		Escherichia	1MXG7@1224,1RMS4@1236,3XQBS@561,COG1215@1,COG1215@2	NA|NA|NA	M	N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N- acetylglucosamine to produce the linear homopolymer poly-beta-1,6- N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide
b1023	316407.85674817	0.0	1372.5	Escherichia	pgaB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016787,GO:0016810,GO:0043170,GO:0043412,GO:0071704,GO:0098732		ko:K11931	ko02026,map02026				ko00000,ko00001,ko01000				Escherichia	1MWR2@1224,1RP7J@1236,3XN4N@561,COG0726@1,COG0726@2,COG1649@1,COG1649@2	NA|NA|NA	M	Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl- D-glucosamine (PGA), a biofilm adhesin polysaccharide. N- deacetylation promotes PGA export through the PgaA porin
b1024	155864.EDL933_1451	0.0	1656.7	Escherichia	pgaA			ko:K11935	ko02026,map02026				ko00000,ko00001				Escherichia	1RA3P@1224,1RY13@1236,3XNBM@561,COG0457@1,COG0457@2	NA|NA|NA	S	Exports the biofilm adhesin polysaccharide poly-beta- 1,6-N-acetyl-D-glucosamine (PGA) across the outer membrane. The PGA transported seems to be partially N-deacetylated since N- deacetylation of PGA by PgaB is needed for PGA export through the PgaA porin
b1025	511145.b1025	3.6e-252	877.1	Escherichia	ycdT	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0032879,GO:0042710,GO:0044010,GO:0044464,GO:0044764,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0051704,GO:0052621,GO:0065007,GO:0071944,GO:0090605,GO:0090609											Escherichia	1MZV7@1224,1SC2U@1236,3XRI4@561,COG2199@1,COG3706@2	NA|NA|NA	T	swimming returns to normal when residues 359-360 are both mutated to Ala. Overexpression also leads to a 20-fold increase in c-di-GMP levels in vivo. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
b1026	316407.1736794	5.7e-171	606.7	Gammaproteobacteria													Escherichia	1MVXQ@1224,1RR4F@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
b1027	1440052.EAKF1_ch3017c	7.7e-43	179.5	Escherichia		GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K07483					ko00000				Escherichia	1RHBZ@1224,1S69Y@1236,3XR2P@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
b1028	481805.EcolC_2568	1.3e-50	205.3	Bacteria													Escherichia	COG0331@1,COG0331@2	NA|NA|NA	I	[acyl-carrier-protein] S-malonyltransferase activity
b1029	316407.4062596	1.9e-178	631.7	Gammaproteobacteria													Escherichia	1R77S@1224,1S0M0@1236,28KHX@1,2ZA3B@2	NA|NA|NA		
b1033	316407.4062597	8.3e-184	649.4	Escherichia	ghrA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120		R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000			iECOK1_1307.ECOK1_1138,iECS88_1305.ECS88_1044,iUMN146_1321.UM146_12160	Escherichia	1MW1U@1224,1RRQE@1236,3XNVJ@561,COG0111@1,COG0111@2	NA|NA|NA	EH	Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively
b1034	316407.4062598	6.8e-141	506.5	Escherichia	ycdX	GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006928,GO:0008150,GO:0008270,GO:0009987,GO:0016787,GO:0016788,GO:0040011,GO:0042578,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K04477					ko00000				Escherichia	1MYXV@1224,1RRE9@1236,3XNRR@561,COG1387@1,COG1387@2	NA|NA|NA	E	Belongs to the PHP family
b1035	316407.4062599	9.5e-103	379.4	Escherichia	ycdY	GO:0001539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006928,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0040011,GO:0044424,GO:0044444,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0071973,GO:0071978,GO:0097588											Escherichia	1Q3A7@1224,1RP51@1236,3XMDU@561,COG3381@1,COG3381@2	NA|NA|NA	S	Acts as a chaperone that increases YcdX activity, maybe by facilitating the correct insertion of the zinc ions into the catalytic site of YcdX. Involved in the swarming motility process
b1036	316407.85674821	1.5e-83	315.5	Escherichia	ycdZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RA69@1224,1S1YX@1236,28NYX@1,2ZBVY@2,3XPA5@561	NA|NA|NA	S	Protein of unknown function (DUF1097)
b1037	155864.EDL933_1611	2.2e-151	541.6	Escherichia	csgG	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0019867,GO:0022610,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0033036,GO:0042597,GO:0042710,GO:0042802,GO:0042886,GO:0044010,GO:0044425,GO:0044462,GO:0044464,GO:0044764,GO:0045184,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098552		ko:K06214					ko00000,ko02044				Escherichia	1MVZM@1224,1RQ5F@1236,3XNNF@561,COG1462@1,COG1462@2	NA|NA|NA	M	Curli production assembly transport component CsgG
b1038	199310.c1300	1.9e-71	275.0	Escherichia	csgF	GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0022610,GO:0030312,GO:0030313,GO:0031975,GO:0042710,GO:0044010,GO:0044462,GO:0044464,GO:0044764,GO:0051704,GO:0071944		ko:K04338					ko00000,ko02044				Escherichia	1N4PQ@1224,1SBR1@1236,2DEP1@1,32U3R@2,3XPNS@561	NA|NA|NA	S	May be involved in the biogenesis of curli organelles
b1039	155864.EDL933_1613	1.1e-68	265.8	Escherichia	csgE	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0019867,GO:0022610,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042710,GO:0042802,GO:0042886,GO:0044010,GO:0044462,GO:0044464,GO:0044764,GO:0045184,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944		ko:K04337					ko00000,ko02044				Escherichia	1N6U8@1224,1S46H@1236,2C2E6@1,2ZPXX@2,3XPJH@561	NA|NA|NA	S	May be involved in the biogenesis of curli organelles
b1040	316407.4062613	7.2e-118	429.9	Escherichia	csgD	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031334,GO:0032991,GO:0032993,GO:0043254,GO:0043565,GO:0043900,GO:0044087,GO:0044089,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1900190,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000144,GO:2001141		ko:K04333	ko02026,map02026				ko00000,ko00001,ko03000				Escherichia	1MXI3@1224,1RNEY@1236,3XMP9@561,COG2197@1,COG2197@2	NA|NA|NA	K	necessary for transcription of the csgBAC ymdA operon. Plays a positive role in biofilm formation. May have the capability to respond to starvation and or high cell density by activating csgBA transcription. Low-level constitutive expression confers an adherent curli fimbriae-expressing phenotype, up- regulates 10 genes and down-regulates 14 others
b1041	155864.EDL933_1616	1.5e-24	119.4	Gammaproteobacteria													Escherichia	1NGYJ@1224,1SH6W@1236,2DRE1@1,33BC9@2	NA|NA|NA	S	PFAM Curlin associated repeat
b1042	316407.1651511	3.6e-07	61.6	Escherichia	csgA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006807,GO:0007155,GO:0008150,GO:0008152,GO:0009289,GO:0009987,GO:0016043,GO:0019538,GO:0022610,GO:0042710,GO:0042802,GO:0042995,GO:0043170,GO:0044010,GO:0044238,GO:0044464,GO:0044764,GO:0051704,GO:0071704,GO:0071840,GO:0097435,GO:1901564,GO:1990000		ko:K04334	ko02026,map02026				ko00000,ko00001,ko02044				Escherichia	1RECY@1224,1S5Q8@1236,29Z81@1,30M63@2,3XPAD@561	NA|NA|NA	S	Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin
b1043	316407.4062614	1.7e-51	208.4	Escherichia	csgC			ko:K04336	ko02026,map02026				ko00000,ko00001,ko02044				Escherichia	1N2IV@1224,1S8D1@1236,2CHEZ@1,32UJP@2,3XQ36@561	NA|NA|NA	M	Curli assembly protein
b1044	316407.4062615	5.2e-50	203.4	Escherichia	ymdA												Escherichia	1QSMU@1224,1RW4W@1236,2DK8X@1,308WD@2,3XQ21@561	NA|NA|NA		
b1045	155864.EDL933_1620	3.1e-95	354.4	Escherichia	ymdB	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005515,GO:0008150,GO:0008428,GO:0009892,GO:0010605,GO:0016787,GO:0019213,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0043086,GO:0043900,GO:0044092,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0061463,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1900190,GO:1900231											Escherichia	1RCWP@1224,1S3WJ@1236,3XMM8@561,COG2110@1,COG2110@2	NA|NA|NA	S	Deacetylates O-acetyl-ADP ribose. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization activation
b1046	198214.SF1042	6.3e-276	956.1	Gammaproteobacteria													Escherichia	1MUDJ@1224,1RMIF@1236,COG1502@1,COG1502@2	NA|NA|NA	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes
b1047	316407.4062618	2.6e-219	767.7	Escherichia	mdoC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0008150,GO:0008152,GO:0009311,GO:0016020,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0044238,GO:0044464,GO:0071704,GO:0071944		ko:K11941					ko00000,ko01000				Escherichia	1N4D5@1224,1RREK@1236,3XNHC@561,COG1835@1,COG1835@2	NA|NA|NA	I	Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane
b1048	316407.1651515	5.3e-305	1052.7	Escherichia	mdoG	GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009628,GO:0009987,GO:0016051,GO:0030288,GO:0030313,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0050896,GO:0051273,GO:0051274,GO:0071704,GO:1901576		ko:K03670					ko00000				Escherichia	1MUNX@1224,1RMEB@1236,3XNPJ@561,COG3131@1,COG3131@2	NA|NA|NA	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
b1049	198214.SF1045	0.0	1725.3	Gammaproteobacteria													Escherichia	1MVXZ@1224,1RMGX@1236,COG2943@1,COG2943@2	NA|NA|NA	M	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
b1050	155864.EDL933_1627	1.1e-36	158.7	Escherichia	yceK	GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0033554,GO:0044425,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:0098552											Escherichia	1MZSU@1224,1S9EJ@1236,3XQ12@561,COG5645@1,COG5645@2	NA|NA|NA	S	cellular response to DNA damage stimulus
b1051	155864.EDL933_1628	5.3e-65	253.4	Escherichia	msyB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K12147					ko00000				Escherichia	1RI2H@1224,1S689@1236,291QA@1,2ZPAE@2,3XPRZ@561	NA|NA|NA	S	MsyB protein
b1053	316407.4062627	1e-221	775.8	Escherichia	mdtG	GO:0006810,GO:0006855,GO:0008150,GO:0015893,GO:0042221,GO:0042493,GO:0050896,GO:0051179,GO:0051234,GO:0055085		ko:K08161					ko00000,ko02000	2.A.1.2.20			Escherichia	1MUBP@1224,1RNXS@1236,3XMU2@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b1054	155864.EDL933_1630	1.8e-183	648.3	Escherichia	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005			iSF_1195.SF1061,iS_1188.S1138	Escherichia	1MVNI@1224,1RMZ5@1236,3XNHW@561,COG1560@1,COG1560@2	NA|NA|NA	M	Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)
b1055	316407.4062629	1.5e-194	685.3	Escherichia	yceA			ko:K07146					ko00000				Escherichia	1MUFV@1224,1RNNU@1236,3XN3X@561,COG1054@1,COG1054@2	NA|NA|NA	S	Belongs to the UPF0176 family
b1056	155864.EDL933_1632	5.2e-104	383.6	Escherichia	yceI												Escherichia	1R9XD@1224,1S24R@1236,3XNV9@561,COG2353@1,COG2353@2	NA|NA|NA	S	YceI-like domain
b1057	316407.4062631	1e-104	386.0	Escherichia	yceJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MZ7X@1224,1S3RF@1236,3XPKM@561,COG3038@1,COG3038@2	NA|NA|NA	C	respiratory electron transport chain
b1058	316407.85674826	2.4e-15	87.0	Bacteria													Escherichia	2EH0X@1,33ASZ@2	NA|NA|NA	S	response to acidic pH
b1059	316407.4062632	1.7e-223	781.6	Escherichia	solA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016647,GO:0033554,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050131,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0097159,GO:1901265,GO:1901363		ko:K02846					ko00000,ko01000			iEC042_1314.EC042_1126	Escherichia	1MU7M@1224,1RS24@1236,3XM89@561,COG0665@1,COG0665@2	NA|NA|NA	E	Catalyzes the oxidative demethylation of N-methyl-L- tryptophan
b1060	1440052.EAKF1_ch0368	9.5e-42	175.6	Escherichia	bssS	GO:0008150,GO:0043900,GO:0050789,GO:0050794,GO:0065007,GO:1900190		ko:K12148					ko00000,ko02048				Escherichia	1MZNE@1224,1S8Z0@1236,2CFXH@1,32S2R@2,3XPYZ@561	NA|NA|NA	S	Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway
b1061	155864.EDL933_1637	1e-37	162.2	Escherichia	dinI	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496		ko:K12149					ko00000,ko03400				Escherichia	1N075@1224,1S8YE@1236,2DMSQ@1,32TF2@2,3XQ0R@561	NA|NA|NA	L	Involved in SOS regulation. Inhibits RecA by preventing RecA to bind ssDNA. Can displace ssDNA from RecA
b1062	316407.1651523	5.2e-203	713.4	Escherichia	pyrC	GO:0003674,GO:0003824,GO:0004151,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019637,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000			iSBO_1134.SBO_2002	Escherichia	1MUYP@1224,1RNEN@1236,3XNMF@561,COG0418@1,COG0418@2	NA|NA|NA	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate
b1063	198214.SF1069	1.6e-97	362.1	Gammaproteobacteria													Escherichia	1PWBU@1224,1RPR9@1236,2CFK9@1,2Z7KF@2	NA|NA|NA	S	Lipoprotein
b1064	155864.EDL933_1640	1.7e-119	435.3	Escherichia	grxB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0015036,GO:0015037,GO:0015038,GO:0016491,GO:0016667,GO:0044424,GO:0044444,GO:0044464,GO:0055114		ko:K03675					ko00000,ko03110			iAF1260.b1064,iAPECO1_1312.APECO1_146,iB21_1397.B21_01068,iBWG_1329.BWG_0912,iEC042_1314.EC042_1131,iEC55989_1330.EC55989_1177,iECABU_c1320.ECABU_c12780,iECBD_1354.ECBD_2536,iECB_1328.ECB_01060,iECDH1ME8569_1439.ECDH1ME8569_0999,iECD_1391.ECD_01060,iECED1_1282.ECED1_1208,iECH74115_1262.ECH74115_1443,iECIAI1_1343.ECIAI1_1099,iECIAI39_1322.ECIAI39_2099,iECNA114_1301.ECNA114_1122,iECOK1_1307.ECOK1_1172,iECP_1309.ECP_1056,iECS88_1305.ECS88_1078,iECSE_1348.ECSE_1127,iECSF_1327.ECSF_0963,iECSP_1301.ECSP_1365,iECUMN_1333.ECUMN_1238,iECW_1372.ECW_m1171,iECs_1301.ECs1442,iEKO11_1354.EKO11_2769,iETEC_1333.ETEC_1129,iEcDH1_1363.EcDH1_2582,iEcE24377_1341.EcE24377A_1187,iEcHS_1320.EcHS_A1187,iEcSMS35_1347.EcSMS35_2065,iEcolC_1368.EcolC_2536,iG2583_1286.G2583_1323,iJO1366.b1064,iLF82_1304.LF82_0927,iNRG857_1313.NRG857_05130,iSBO_1134.SBO_2000,iSSON_1240.SSON_1084,iSbBS512_1146.SbBS512_E2262,iUMN146_1321.UM146_12010,iUMNK88_1353.UMNK88_1331,iUTI89_1310.UTI89_C1189,iWFL_1372.ECW_m1171,iY75_1357.Y75_RS05565,iZ_1308.Z1701,ic_1306.c1331	Escherichia	1N9FA@1224,1RMFC@1236,3XN0S@561,COG2999@1,COG2999@2	NA|NA|NA	O	in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase
b1065	199310.c1332	3.6e-224	783.9	Escherichia	mdtH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08162					ko00000,ko02000	2.A.1.2.21			Escherichia	1QS3U@1224,1RNJ6@1236,3XNR6@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Confers resistance to norfloxacin and enoxacin
b1066	1440052.EAKF1_ch0363c	2.3e-115	421.4	Escherichia	rimJ	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03790					ko00000,ko01000,ko03009				Escherichia	1MVG4@1224,1RQPX@1236,3XN9M@561,COG1670@1,COG1670@2	NA|NA|NA	J	This enzyme acetylates the N-terminal alanine of ribosomal protein S5. Plays also a role in the temperature regulation of pap pilin transcription
b1067	316407.4062646	1.6e-114	418.7	Escherichia	yceH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09915					ko00000				Escherichia	1RA13@1224,1RQUQ@1236,3XMG5@561,COG3132@1,COG3132@2	NA|NA|NA	S	Belongs to the UPF0502 family
b1068	316407.4062647	4.1e-175	620.5	Escherichia	yceM			ko:K03810					ko00000				Escherichia	1MVCX@1224,1RP1P@1236,3XNYI@561,COG0673@1,COG0673@2	NA|NA|NA	S	oxidoreductase activity
b1069	155864.EDL933_1645	1.2e-275	955.3	Escherichia	murJ	GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576		ko:K03980					ko00000,ko01011,ko02000	2.A.66.4		iECO103_1326.ECO103_1114	Escherichia	1MUH0@1224,1RMXX@1236,3XMDX@561,COG0728@1,COG0728@2	NA|NA|NA	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
b1070	316407.1651525	1e-69	269.2	Escherichia	flgN			ko:K02399	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1MZUY@1224,1SAU2@1236,3XPTP@561,COG3418@1,COG3418@2	NA|NA|NA	N	Flagella synthesis protein FlgN
b1071	198214.SF1077	2.4e-41	174.5	Gammaproteobacteria													Escherichia	1MZI7@1224,1S8UX@1236,COG2747@1,COG2747@2	NA|NA|NA	N	negative regulator of flagellin synthesis
b1072	316407.4062649	3.7e-114	417.5	Escherichia	flgA	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588		ko:K02386	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1NY6E@1224,1RMY1@1236,3XN09@561,COG1261@1,COG1261@2	NA|NA|NA	N	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
b1073	198214.SF1079	2.2e-67	261.5	Gammaproteobacteria													Escherichia	1MZ8P@1224,1S9DS@1236,COG1815@1,COG1815@2	NA|NA|NA	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body
b1074	155864.EDL933_1651	5.7e-65	253.4	Escherichia	flgC	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02388	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1RHI3@1224,1S653@1236,3XPIV@561,COG1558@1,COG1558@2	NA|NA|NA	N	Belongs to the flagella basal body rod proteins family
b1075	316407.4062652	8.5e-117	426.4	Escherichia	flgD	GO:0001539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044424,GO:0044444,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02389	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1MXCG@1224,1RPZI@1236,3XNA0@561,COG1843@1,COG1843@2	NA|NA|NA	N	Required for flagellar hook formation. May act as a scaffolding protein
b1076	316407.85674830	7.9e-219	766.1	Escherichia	flgE	GO:0001539,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044424,GO:0044444,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02390	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1MU5J@1224,1RMWX@1236,3XNMQ@561,COG1749@1,COG1749@2	NA|NA|NA	N	bacterial-type flagellum-dependent swarming motility
b1077	316407.4062655	4.6e-132	477.2	Escherichia	flgF	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02391	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1NZWQ@1224,1RNVX@1236,3XM3P@561,COG4787@1,COG4787@2	NA|NA|NA	N	bacterial-type flagellum-dependent swarming motility
b1078	155864.EDL933_1655	1.5e-138	498.8	Escherichia	flgG	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009279,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044462,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071944,GO:0071973,GO:0071978,GO:0097588		ko:K02392	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1MVMA@1224,1RMJ2@1236,3XNKZ@561,COG4786@1,COG4786@2	NA|NA|NA	N	Belongs to the flagella basal body rod proteins family
b1079	155864.EDL933_1656	3.5e-126	457.6	Escherichia	flgH	GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0050896		ko:K02393	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1RDEY@1224,1S3XK@1236,3XM5H@561,COG2063@1,COG2063@2	NA|NA|NA	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
b1080	198214.SF1084	1.4e-190	672.2	Gammaproteobacteria													Escherichia	1MVKW@1224,1RMRB@1236,COG1706@1,COG1706@2	NA|NA|NA	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
b1081	316407.4062659	6.2e-171	606.7	Escherichia	flgJ	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588		ko:K02395					ko00000,ko02035				Escherichia	1MX2W@1224,1RPGY@1236,3XMH9@561,COG1705@1,COG1705@2,COG3951@1,COG3951@2	NA|NA|NA	MNOU	Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space
b1082	316407.1651528	1.3e-296	1025.0	Escherichia	flgK	GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0044085,GO:0044780,GO:0044781,GO:0070925,GO:0071840		ko:K02396	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1MV2M@1224,1RMEA@1236,3XPGC@561,COG1256@1,COG1256@2	NA|NA|NA	N	flagellar hook-associated protein
b1083	316407.1651529	3e-165	587.8	Escherichia	flgL	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464		ko:K02397	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1PJUJ@1224,1RPNR@1236,3XN6Z@561,COG1344@1,COG1344@2	NA|NA|NA	N	Flagellar hook-associated protein 3
b1084	316407.1651530	0.0	1313.9	Escherichia	rne	GO:0000287,GO:0000966,GO:0000967,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008312,GO:0008995,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0017151,GO:0019222,GO:0019439,GO:0019899,GO:0022607,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034655,GO:0034660,GO:0042254,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043462,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0046872,GO:0048519,GO:0050789,GO:0050790,GO:0051095,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051336,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902280	3.1.26.12	ko:K08300	ko03018,map03018	M00394			ko00000,ko00001,ko00002,ko01000,ko03009,ko03019				Escherichia	1MV65@1224,1RMDS@1236,3XMU0@561,COG1530@1,COG1530@2	NA|NA|NA	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs
b1085	198214.SF1089	6.3e-59	233.0	Gammaproteobacteria													Escherichia	1NVA5@1224,1SN89@1236,2C7GC@1,33UU4@2	NA|NA|NA	S	Protein of unknown function (DUF2655)
b1086	198214.SF1090	1e-176	625.9	Gammaproteobacteria													Escherichia	1MVDX@1224,1RPAN@1236,COG0564@1,COG0564@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil
b1087	198214.SF1091	3e-107	394.4	Gammaproteobacteria													Escherichia	1RDA9@1224,1S3TQ@1236,COG0424@1,COG0424@2	NA|NA|NA	D	Maf-like protein
b1088	155864.EDL933_1665	5.4e-92	343.6	Escherichia	yceD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07040					ko00000				Escherichia	1PGKW@1224,1RRK3@1236,3XMXZ@561,COG1399@1,COG1399@2	NA|NA|NA	S	Plays a role in synthesis, processing and or stability of 23S rRNA
b1089	1114922.CIFAM_06_03660	6.1e-24	115.9	Citrobacter													Escherichia	1N6RF@1224,1SC9G@1236,3WYWW@544,COG0333@1,COG0333@2	NA|NA|NA	J	Ribosomal L32p protein family
b1090	316407.85674834	2.8e-191	674.5	Escherichia	plsX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0071704,GO:0090407,GO:1901576	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004			iEcDH1_1363.EcDH1_2557,iSFxv_1172.SFxv_1246,iY75_1357.Y75_RS05695	Escherichia	1MVM3@1224,1RM7R@1236,3XMRS@561,COG0416@1,COG0416@2	NA|NA|NA	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
b1091	155864.EDL933_1668	5e-176	623.6	Escherichia	fabH	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0071704	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004			iAF1260.b1091,iAPECO1_1312.APECO1_172,iBWG_1329.BWG_0939,iE2348C_1286.E2348C_1183,iEC55989_1330.EC55989_1203,iECABU_c1320.ECABU_c13040,iECDH10B_1368.ECDH10B_1163,iECDH1ME8569_1439.ECDH1ME8569_1026,iECED1_1282.ECED1_1234,iECH74115_1262.ECH74115_1470,iECIAI39_1322.ECIAI39_2070,iECO103_1326.ECO103_1136,iECO111_1330.ECO111_1368,iECO26_1355.ECO26_1424,iECOK1_1307.ECOK1_1198,iECP_1309.ECP_1083,iECS88_1305.ECS88_1105,iECSP_1301.ECSP_1392,iECW_1372.ECW_m1199,iECs_1301.ECs1469,iEKO11_1354.EKO11_2743,iETEC_1333.ETEC_1156,iEcDH1_1363.EcDH1_2556,iEcE24377_1341.EcE24377A_1212,iEcSMS35_1347.EcSMS35_2036,iG2583_1286.G2583_1351,iJO1366.b1091,iJR904.b1091,iLF82_1304.LF82_0609,iNRG857_1313.NRG857_05260,iSSON_1240.SSON_1111,iSbBS512_1146.SbBS512_E2233,iUMN146_1321.UM146_11870,iUMNK88_1353.UMNK88_1361,iUTI89_1310.UTI89_C1216,iWFL_1372.ECW_m1199,iY75_1357.Y75_RS05700,iZ_1308.Z1730,ic_1306.c1360	Escherichia	1MU9N@1224,1RNIR@1236,3XMAF@561,COG0332@1,COG0332@2	NA|NA|NA	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
b1092	199310.c1361	1.7e-168	598.6	Escherichia	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004			iEcE24377_1341.EcE24377A_1213	Escherichia	1MV6N@1224,1RNH3@1236,3XN0C@561,COG0331@1,COG0331@2	NA|NA|NA	I	malonyl CoA-acyl carrier protein transacylase
b1093	198214.SF1097	9.6e-127	459.5	Gammaproteobacteria													Escherichia	1MU6X@1224,1RMBB@1236,COG1028@1,COG1028@2	NA|NA|NA	IQ	reductase
b1094	1005994.GTGU_00900	1.5e-33	148.3	Gammaproteobacteria													Escherichia	1MZ4P@1224,1S8X4@1236,COG0236@1,COG0236@2	NA|NA|NA	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis
b1095	754331.AEME01000001_gene1402	6.4e-232	809.7	Escherichia	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004			iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365	Escherichia	1MU1X@1224,1RMDE@1236,3XMVA@561,COG0304@1,COG0304@2	NA|NA|NA	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
b1096	316407.1651539	3.3e-152	544.3	Escherichia	pabC	GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008696,GO:0016829,GO:0016830,GO:0016833,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	4.1.3.38	ko:K02619	ko00790,map00790		R05553	RC01843,RC02148	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_177,iE2348C_1286.E2348C_1188,iECED1_1282.ECED1_1239,iECNA114_1301.ECNA114_1153,iECOK1_1307.ECOK1_1203,iECS88_1305.ECS88_1110,iECSF_1327.ECSF_0995,iECUMN_1333.ECUMN_1273,iUMN146_1321.UM146_11845,iUTI89_1310.UTI89_C1222,ic_1306.c1366	Escherichia	1MZAK@1224,1RPPG@1236,3XMCE@561,COG0115@1,COG0115@2	NA|NA|NA	H	4-amino-4-deoxychorismate lyase
b1097	316407.85674836	2.5e-189	667.9	Escherichia	mltG	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564		ko:K07082					ko00000				Escherichia	1MUQF@1224,1RMWD@1236,3XP1G@561,COG1559@1,COG1559@2	NA|NA|NA	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
b1098	198214.SF1102	4.7e-114	417.2	Gammaproteobacteria													Escherichia	1MV9C@1224,1S26C@1236,COG0125@1,COG0125@2	NA|NA|NA	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
b1099	316407.1651540	2.1e-193	681.4	Escherichia	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Escherichia	1MY1W@1224,1RNYA@1236,3XMF9@561,COG0470@1,COG0470@2	NA|NA|NA	L	Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The gamma complex (gamma(3),delta,delta') is thought to load beta dimers onto DNA by binding ATP which alters the complex's conformation so it can bind beta sliding clamp dimers and open them at one interface. Primed DNA is recognized, ATP is hydrolyzed releasing the gamma complex and closing the beta sliding clamp ring around the primed DNA
b1100	155864.EDL933_1677	2.1e-151	541.6	Escherichia	ycfH	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575		ko:K03424					ko00000,ko01000				Escherichia	1MUC0@1224,1RP6E@1236,3XMJ2@561,COG0084@1,COG0084@2	NA|NA|NA	L	metal-dependent hydrolase YcfH
b1101	155864.EDL933_1678	1.2e-266	925.2	Escherichia	ptsG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009401,GO:0015144,GO:0015749,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090564,GO:1904659	2.7.1.199	ko:K02778,ko:K02779	ko00010,ko00520,ko02060,ko05111,map00010,map00520,map02060,map05111	M00265	R02738	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1			Escherichia	1MY1V@1224,1RMYZ@1236,3XMP0@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration
b1102	316407.1651542	0.0	1480.7	Escherichia	fhuE	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K16088					ko00000,ko02000	1.B.14.1.10,1.B.14.1.3,1.B.14.1.8		iSDY_1059.SDY_2048	Escherichia	1MW5E@1224,1RMBD@1236,3XM3J@561,COG4773@1,COG4773@2	NA|NA|NA	P	Outer-membrane receptor for Fe(III)-coprogen, Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid
b1103	155864.EDL933_1681	4.9e-60	236.9	Escherichia	hinT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019478,GO:0019752,GO:0043436,GO:0043530,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055130,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606		ko:K02503					ko00000,ko04147				Escherichia	1RDCJ@1224,1S3QE@1236,3XPPK@561,COG0537@1,COG0537@2	NA|NA|NA	FG	Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate), guanosine 5'monophosphomorpholidate (GMP-morpholidate) and tryptamine 5'guanosine monophosphate (TpGd). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha- acetyl lysine methyl ester)) generated by lysine--tRNA ligase, and lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)). Is essential for the activity of the enzyme D- alanine dehydrogenase (DadA) and is required for E.coli to grow on D-alanine as a sole carbon source. Is also required for growth at high salt concentrations
b1104	316407.4062668	7e-65	253.1	Escherichia	ycfL	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1RED7@1224,1S4SB@1236,3XPR8@561,COG5633@1,COG5633@2	NA|NA|NA	S	cellular response to DNA damage stimulus
b1105	155864.EDL933_1683	4.2e-94	350.9	Escherichia	lpoB	GO:0000270,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0019899,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043085,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044093,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576		ko:K07337					ko00000				Escherichia	1QFS9@1224,1RSK3@1236,3XP7D@561,COG3417@1,COG3417@2	NA|NA|NA	M	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
b1106	316407.4062670	7.1e-163	579.7	Escherichia	thiK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019165,GO:0044237	2.7.1.89	ko:K07251	ko00730,ko01100,map00730,map01100		R02134	RC00002,RC00017	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_1198,iEC042_1314.EC042_1176,iECED1_1282.ECED1_1249,iECO111_1330.ECO111_1383,iECO26_1355.ECO26_1439,iECUMN_1333.ECUMN_1284	Escherichia	1MURU@1224,1RNUN@1236,3XMAG@561,COG0510@1,COG0510@2	NA|NA|NA	F	Catalyzes the phosphorylation of thiamine to thiamine phosphate
b1107	316407.4062671	1.1e-192	679.1	Escherichia	nagZ	GO:0000270,GO:0003674,GO:0003824,GO:0004553,GO:0004563,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0015929,GO:0016787,GO:0016798,GO:0030203,GO:0043170,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901564	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000			iSFV_1184.SFV_1127,iUMN146_1321.UM146_11790	Escherichia	1MVAJ@1224,1RMQF@1236,3XN5W@561,COG1472@1,COG1472@2	NA|NA|NA	M	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides
b1108	1440052.EAKF1_ch0323c	6.4e-104	383.3	Escherichia	ycfP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07000					ko00000				Escherichia	1NV1Y@1224,1RPQX@1236,3XM60@561,COG3150@1,COG3150@2	NA|NA|NA	S	Belongs to the UPF0227 family
b1109	316407.1651546	3.5e-249	867.1	Escherichia	ndh	GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0036094,GO:0042592,GO:0043167,GO:0043168,GO:0044237,GO:0044425,GO:0044464,GO:0045333,GO:0048037,GO:0048878,GO:0050136,GO:0050660,GO:0050662,GO:0050801,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0097159,GO:0098771,GO:0098796,GO:1901265,GO:1901363,GO:1902494	1.6.99.3	ko:K03885	ko00190,map00190				ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_2051	Escherichia	1MX96@1224,1RM9I@1236,3XP16@561,COG1252@1,COG1252@2	NA|NA|NA	C	NADH dehydrogenase
b1110	199310.c1383	9.9e-81	306.2	Escherichia	ycfJ	GO:0008150,GO:0043900,GO:0050789,GO:0050794,GO:0065007,GO:1900190											Escherichia	1MVWD@1224,1RQR9@1236,3XNC0@561,COG3134@1,COG3134@2	NA|NA|NA	S	regulation of single-species biofilm formation
b1111	316407.85674839	1e-116	426.0	Escherichia	ycfQ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046688,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K22041					ko00000,ko03000				Escherichia	1NCEF@1224,1RQ8N@1236,3XMVB@561,COG1309@1,COG1309@2	NA|NA|NA	K	response to copper ion
b1112	155864.EDL933_1690	1.2e-36	158.7	Escherichia	bhsA	GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0010035,GO:0010038,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0042221,GO:0044462,GO:0044464,GO:0046688,GO:0050896,GO:0071944		ko:K12151					ko00000,ko02048				Escherichia	1MZS8@1224,1S94M@1236,2E4GN@1,32ZBU@2,3XQ2D@561	NA|NA|NA	M	Reduces the permeability of the outer membrane to copper
b1113	316407.4062682	2e-180	638.3	Escherichia	ycfS	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0070004,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576		ko:K19236	ko01503,map01503				ko00000,ko00001,ko01002,ko01011				Escherichia	1MVYT@1224,1RMNC@1236,3XNS9@561,COG1376@1,COG1376@2,COG1388@1,COG1388@2	NA|NA|NA	M	Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L- Lys- bond on the terminal residue of Lpp
b1114	316407.1651547	0.0	2271.5	Escherichia	mfd	GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K03723	ko03420,map03420				ko00000,ko00001,ko01000,ko03400				Escherichia	1MUXG@1224,1RNCU@1236,3XMAX@561,COG1197@1,COG1197@2	NA|NA|NA	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
b1115	316407.4062683	1.1e-184	652.5	Escherichia	ycfT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1Q61M@1224,1RR84@1236,3XNED@561,COG4763@1,COG4763@2	NA|NA|NA	S	transferase activity, transferring acyl groups other than amino-acyl groups
b1116	155864.EDL933_1694	1.1e-204	719.2	Escherichia	lolC	GO:0005575,GO:0005623,GO:0005886,GO:0008104,GO:0008150,GO:0016020,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778		ko:K09808	ko02010,map02010	M00255			ko00000,ko00001,ko00002,ko02000	3.A.1.125			Escherichia	1MVV7@1224,1RMP9@1236,3XMQJ@561,COG4591@1,COG4591@2	NA|NA|NA	M	Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA
b1117	316407.85674841	1.3e-125	455.7	Escherichia	lolD	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008104,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1990778		ko:K09810	ko02010,map02010	M00255			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125			Escherichia	1MVSQ@1224,1RMWK@1236,3XN61@561,COG1136@1,COG1136@2	NA|NA|NA	V	Part of the ABC transporter complex LolCDE involved in the translocation of
b1118	316407.4062690	1.1e-218	765.8	Escherichia	lolE	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0098796,GO:0098797		ko:K09808	ko02010,map02010	M00255			ko00000,ko00001,ko00002,ko02000	3.A.1.125			Escherichia	1MVV7@1224,1RMP9@1236,3XNMR@561,COG4591@1,COG4591@2	NA|NA|NA	M	system transmembrane protein lolE
b1119	316407.4062691	8.4e-173	612.8	Escherichia	nagK	GO:0003674,GO:0003824,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0045127,GO:0046835,GO:0071704	2.7.1.59	ko:K00884	ko00520,ko01100,map00520,map01100		R01201	RC00002,RC00017	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_1211	Escherichia	1MU94@1224,1RNHE@1236,3XN5F@561,COG1940@1,COG1940@2	NA|NA|NA	F	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P
b1120	316407.4062692	7e-158	563.1	Escherichia	cobB	GO:0002252,GO:0002376,GO:0003674,GO:0003824,GO:0006464,GO:0006476,GO:0006807,GO:0006935,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018205,GO:0019213,GO:0019538,GO:0033558,GO:0034979,GO:0034983,GO:0035601,GO:0036048,GO:0036049,GO:0036055,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0071704,GO:0098542,GO:0098732,GO:0140096,GO:1901564		ko:K12410					ko00000,ko01000				Escherichia	1MUK1@1224,1RMX5@1236,3XMVH@561,COG0846@1,COG0846@2	NA|NA|NA	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
b1121	316407.4062693	1.2e-140	505.8	Escherichia	ycfZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1PD03@1224,1SY68@1236,3XM72@561,COG1512@1,COG1512@2	NA|NA|NA	S	TPM domain
b1122	316407.85674842	4.1e-83	313.9	Escherichia	ymfA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1NKBF@1224,1TGGD@1236,2E9YS@1,3344A@2,3XQZJ@561	NA|NA|NA	S	Protein of unknown function (DUF3592)
b1123	198214.SF1125	5.6e-205	719.9	Gammaproteobacteria													Escherichia	1MUYW@1224,1RM7W@1236,COG0687@1,COG0687@2	NA|NA|NA	P	Required for the activity of the bacterial periplasmic transport system of putrescine
b1124	155864.EDL933_1700	2.1e-135	488.4	Escherichia	potC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351		ko:K11070	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1		iSBO_1134.SBO_1939	Escherichia	1MVC5@1224,1RQB7@1236,3XP5B@561,COG1177@1,COG1177@2	NA|NA|NA	P	Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine
b1125	362663.ECP_1119	2e-144	518.5	Escherichia	potB			ko:K11071	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko02000	3.A.1.11.1		iE2348C_1286.E2348C_1266,iECUMN_1333.ECUMN_1368,iSBO_1134.SBO_1916	Escherichia	1MVGM@1224,1RNNZ@1236,3XPCI@561,COG1176@1,COG1176@2	NA|NA|NA	P	Binding-protein-dependent transport system inner membrane component
b1126	155864.EDL933_1769	5.5e-214	750.0	Escherichia	potA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0097159,GO:0097367,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351	3.6.3.31	ko:K11072	ko02010,map02010	M00299			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1		iB21_1397.B21_01132,iECBD_1354.ECBD_2473,iECB_1328.ECB_01124,iECD_1391.ECD_01124,iECO111_1330.ECO111_1474,iECO26_1355.ECO26_1643,iEcHS_1320.EcHS_A1246,iEcolC_1368.EcolC_2477,iSBO_1134.SBO_1915,iSSON_1240.SSON_1144,iSbBS512_1146.SbBS512_E1304,iUMNK88_1353.UMNK88_1456	Escherichia	1MU3I@1224,1RNPX@1236,3XMSQ@561,COG3842@1,COG3842@2	NA|NA|NA	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system
b1127	316407.1651556	2.5e-236	824.3	Escherichia	pepT	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0034701,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045148,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.4	ko:K01258					ko00000,ko01000,ko01002				Escherichia	1MV7D@1224,1RMKZ@1236,3XM5J@561,COG2195@1,COG2195@2	NA|NA|NA	E	Cleaves the N-terminal amino acid of tripeptides
b1128	316407.4062695	1.1e-227	795.4	Escherichia	ycfD	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0018193,GO:0018195,GO:0019538,GO:0030961,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901564	1.14.11.47	ko:K18850					ko00000,ko01000,ko03009				Escherichia	1MW30@1224,1RN2Q@1236,3XN3B@561,COG2850@1,COG2850@2	NA|NA|NA	S	peptidyl-arginine hydroxylation
b1129	316407.1651557	3.7e-271	940.3	Escherichia	phoQ	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010350,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035556,GO:0036211,GO:0042578,GO:0042594,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07637	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744			ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022				Escherichia	1QTVU@1224,1RPFY@1236,3XMJ7@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
b1130	316407.1651558	2.1e-120	438.3	Escherichia	phoP	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K07660	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744			ko00000,ko00001,ko00002,ko01504,ko02022				Escherichia	1N0YI@1224,1RMWT@1236,3XN39@561,COG0745@1,COG0745@2	NA|NA|NA	K	Member of the two-component regulatory system PhoP PhoQ involved in adaptation to low Mg(2 ) environments and the control of acid resistance genes. In low periplasmic Mg(2 ), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2 ), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG (By similarity). Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes
b1131	199310.c1510	2.4e-264	917.5	Escherichia	purB	GO:0003674,GO:0003824,GO:0004018,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000			iAF1260.b1131,iBWG_1329.BWG_0979,iE2348C_1286.E2348C_1272,iEC042_1314.EC042_1202,iECABU_c1320.ECABU_c13450,iECDH10B_1368.ECDH10B_1203,iECP_1309.ECP_1126,iECUMN_1333.ECUMN_1375,iETEC_1333.ETEC_1255,iEcHS_1320.EcHS_A1251,iEcolC_1368.EcolC_2472,iJO1366.b1131,iJR904.b1131,iLF82_1304.LF82_1774,iNRG857_1313.NRG857_05460,iY75_1357.Y75_RS05905,ic_1306.c1510	Escherichia	1MV4B@1224,1RN93@1236,3XNCV@561,COG0015@1,COG0015@2	NA|NA|NA	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
b1132	316407.4062696	2.4e-110	404.8	Escherichia	hflD	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:0098562		ko:K07153					ko00000				Escherichia	1RI8B@1224,1RPCC@1236,3XMJX@561,COG2915@1,COG2915@2	NA|NA|NA	S	Negative regulator of phage lambda lysogenization. Contributes to the degradation of the phage regulatory protein CII. Acts probably by holding CII on the membrane surface, away from the target promoters, but close to the FtsH protease
b1133	316407.4062697	4e-217	760.4	Escherichia	mnmA	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122		R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016				Escherichia	1MUT1@1224,1RMAK@1236,3XN22@561,COG0482@1,COG0482@2	NA|NA|NA	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs
b1134	155864.EDL933_1803	2.7e-87	327.8	Escherichia	nudJ	GO:0003674,GO:0003824,GO:0004787,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0017111		ko:K12152					ko00000,ko01000			iSbBS512_1146.SbBS512_E1312	Escherichia	1N03W@1224,1S970@1236,3XNRP@561,COG1051@1,COG1051@2	NA|NA|NA	F	Belongs to the Nudix hydrolase family. NudJ subfamily
b1135	316407.4062699	8.2e-122	443.0	Escherichia	rluE	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.20	ko:K06181					ko00000,ko01000,ko03009				Escherichia	1R9VV@1224,1S1ZX@1236,3XMPV@561,COG1187@1,COG1187@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 2457 in 23S ribosomal RNA
b1136	316407.1651560	7.3e-244	849.4	Escherichia	icd	GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000			e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930	Escherichia	1MW3J@1224,1RNMD@1236,3XMJ1@561,COG0538@1,COG0538@2	NA|NA|NA	C	Isocitrate dehydrogenase
b1137	316407.85674844	5.8e-123	446.8	Gammaproteobacteria													Escherichia	1NBF2@1224,1SMA8@1236,COG2227@1,COG2227@2	NA|NA|NA	H	Tellurite resistance protein TehB
b1138	316407.85674845	2.4e-127	461.5	Gammaproteobacteria													Escherichia	1NTN4@1224,1SMZW@1236,2EZER@1,33SJW@2	NA|NA|NA		
b1139	316407.1651567	2.2e-170	604.7	Gammaproteobacteria													Escherichia	1NJ5S@1224,1SQWJ@1236,2ER0C@1,33IJV@2	NA|NA|NA	O	Interacts with a short DNA sequence about one-quarter of the way into the major capsid protein gene 23 of T4
b1140	316407.4062718	1.3e-212	745.3	Escherichia	intE	GO:0003674,GO:0005488,GO:0005515,GO:0046982,GO:0046983											Escherichia	1MX7E@1224,1RNX5@1236,3XMG9@561,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
b1141	316407.4062719	2.1e-38	164.5	Gammaproteobacteria													Escherichia	1N4TK@1224,1SC06@1236,2E6QN@1,32V4N@2	NA|NA|NA	S	DNA recombination
b1142	199310.c3200	4.8e-19	100.5	Escherichia	yfdP	GO:0006950,GO:0006979,GO:0008150,GO:0050896											Escherichia	1N8YH@1224,1S4F3@1236,2A7EB@1,30WBS@2,3XPM3@561	NA|NA|NA		
b1144	316407.85674848	5.2e-50	203.4	Gammaproteobacteria													Escherichia	1P65M@1224,1SW02@1236,2CANK@1,2ZG0E@2	NA|NA|NA		
b1145	316407.4062720	9.1e-132	476.1	Gammaproteobacteria													Escherichia	1R40A@1224,1RZV5@1236,COG1974@1,COG1974@2	NA|NA|NA	K	nucleic acid-templated transcription
b1146	316407.85674849	1.3e-30	138.3	Escherichia	croE												Escherichia	1NCTA@1224,1SCVG@1236,3XR7U@561,COG4197@1,COG4197@2	NA|NA|NA	K	Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT
b1147	316407.4062722	3.4e-100	370.9	Escherichia	ymfL												Escherichia	1RD9W@1224,1S51F@1236,29HZS@1,304WU@2,3XPU7@561	NA|NA|NA		
b1149	316407.4062724	2.5e-269	934.1	Escherichia													Escherichia	1MW7K@1224,1RP8Z@1236,3XQ3E@561,COG1802@1,COG1802@2,COG4626@1,COG4626@2	NA|NA|NA	K	Phage Terminase
b4692	1440052.EAKF1_ch1458c	2.5e-36	157.5	Escherichia	yfdO	GO:0006950,GO:0006979,GO:0008150,GO:0050896											Escherichia	1R605@1224,1S0V3@1236,3XPII@561,COG1846@1,COG1846@2	NA|NA|NA	K	Helix-turn-helix domain
b4693	316407.4062724	1.7e-223	781.6	Escherichia													Escherichia	1MW7K@1224,1RP8Z@1236,3XQ3E@561,COG1802@1,COG1802@2,COG4626@1,COG4626@2	NA|NA|NA	K	Phage Terminase
b1150	316407.4062725	1.3e-24	118.2	Escherichia	ymfR												Escherichia	1N9J1@1224,1SE2H@1236,2ECJE@1,336HG@2,3XR7R@561	NA|NA|NA		
b1151	316407.4062726	1.5e-88	332.0	Escherichia													Escherichia	1MUP5@1224,1RPB0@1236,3XQR9@561,COG4695@1,COG4695@2	NA|NA|NA	S	Phage portal protein
b1152	1225789.M1FQW3_9CAUD	3.5e-143	514.2	Myoviridae													Escherichia	4QAMU@10239,4QI0J@10662,4QPEV@28883,4QV4U@35237	NA|NA|NA	S	Baseplate J-like protein
b1153	316407.4062728	6.2e-113	413.3	Escherichia	ymfQ												Escherichia	1N3CF@1224,1S3EK@1236,3XR6Q@561,COG3778@1,COG3778@2	NA|NA|NA	S	Uncharacterised protein conserved in bacteria (DUF2313)
b1154	316407.4062729	6.1e-114	416.8	Escherichia	stfP												Escherichia	1RIG4@1224,1S7T1@1236,2C0FK@1,32R6X@2,3XR18@561	NA|NA|NA		
b1155	316407.85674852	2.1e-75	288.1	Gammaproteobacteria													Escherichia	1P3E1@1224,1SSUS@1236,2ACIU@1,31251@2	NA|NA|NA	S	Caudovirales tail fibre assembly protein, lambda gpK
b1156	316407.85674853	7.9e-103	379.8	Escherichia	tfaE												Escherichia	1RDMN@1224,1S6U8@1236,3XR1I@561,COG2110@1,COG2110@2	NA|NA|NA	S	Caudovirales tail fibre assembly protein, lambda gpK
b1157	481805.EcolC_2758	4.3e-36	157.9	Gammaproteobacteria													Escherichia	1N8U4@1224,1T4IP@1236,COG5301@1,COG5301@2	NA|NA|NA	S	Phage Tail Collar Domain
b1158	316407.1651570	6.4e-99	366.7	Escherichia	pinE	GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360											Escherichia	1MXXT@1224,1S08N@1236,3XQEI@561,COG1961@1,COG1961@2	NA|NA|NA	L	This protein catalyzes the inversion of an 1800-bp E.coli DNA fragment, the P region, which can exist in either orientation. The function of the inversion is not yet clear
b1159	316407.1651571	3e-161	574.3	Escherichia	mcrA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008327,GO:0036094,GO:0043565,GO:0097159,GO:1901265,GO:1901363		ko:K07451					ko00000,ko01000,ko02048				Escherichia	1RATU@1224,1SC8S@1236,3XRDW@561,COG1403@1,COG1403@2	NA|NA|NA	V	Restriction of 5-methyl and 5-hydroxymethylcytosines at the specific DNA sequence C(me)CGG
b4519	481805.EcolC_2467	4.9e-23	112.8	Escherichia	icd	GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000			e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930	Escherichia	1MW3J@1224,1RNMD@1236,3XMJ1@561,COG0538@1,COG0538@2	NA|NA|NA	C	Isocitrate dehydrogenase
b1160	316407.85674854	1.7e-59	235.0	Escherichia	iraM	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009268,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0009991,GO:0010350,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042176,GO:0042177,GO:0042594,GO:0043856,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051248,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071214,GO:0071467,GO:0071468,GO:0071496,GO:0080090,GO:0104004,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K21638					ko00000				Escherichia	1NBRF@1224,1SDBJ@1236,2E777@1,331R2@2,3XR6J@561	NA|NA|NA	K	Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation
b1161	316407.85674855	1.6e-70	271.9	Escherichia	ycgX												Escherichia	1N5MB@1224,1S80R@1236,3XR27@561,COG5562@1,COG5562@2	NA|NA|NA	S	Protein of unknown function (DUF1398)
b1162	316407.4062743	2.9e-139	501.1	Escherichia	ycgE	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K21972					ko00000,ko03000				Escherichia	1R9SN@1224,1S967@1236,3XNWY@561,COG0789@1,COG0789@2	NA|NA|NA	K	Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR, allowing it to be released from its operator
b1163	316407.4062744	4.2e-228	797.0	Escherichia	JD73_24940	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008134,GO:0008150,GO:0009314,GO:0009416,GO:0009628,GO:0009637,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0033613,GO:0036094,GO:0043167,GO:0043168,GO:0043433,GO:0044092,GO:0048037,GO:0048519,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070491,GO:0080090,GO:0097159,GO:1901265,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K21973					ko00000				Escherichia	1MVJY@1224,1RPDW@1236,3XNKP@561,COG2200@1,COG2200@2	NA|NA|NA	T	Binds to and releases the BluR repressor from its bound DNA target in a blue light-dependent (470 nm) fashion. A shift to low temperature also triggers a BluF-mediated relief of repression by BluR, suggesting BluF may serve as a thermometer. Blue light may act to increase the affinity of BluF for BluR, allowing it to be released from its operator. The protein has a reversible photocycle, and undergoes structural changes, probably in the EAL domain, in response to light
b1164	316407.85674856	1.5e-36	158.3	Escherichia	ycgZ	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K21974					ko00000				Escherichia	1N1WZ@1224,1SB5M@1236,2CBKZ@1,32RTK@2,3XQ4P@561	NA|NA|NA	S	Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component
b1165	316407.85674857	1.9e-40	171.4	Gammaproteobacteria													Escherichia	1P43J@1224,1SU1Z@1236,291Y3@1,2ZPHM@2	NA|NA|NA	S	Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB
b1166	316407.85674858	7.9e-39	166.0	Escherichia	ariR	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0010035,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050896,GO:0097159,GO:1901363,GO:1901700		ko:K21976					ko00000				Escherichia	1N7EC@1224,1SFSW@1236,2ECN4@1,336K1@2,3XQ5H@561	NA|NA|NA	K	Probably a connector protein for RcsB C regulation of biofilm and acid-resistance, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, via the Rcs phosphorelay. Regulates expression of genes involved in acid-resistance and biofilm formation, including the RcsB C two-component system. May be a non-specific DNA-binding protein that binds genes and or intergenic regions via a geometric recognition. Also confers resistance to H(2)O(2). Overexpression at 28 and 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB
b1167	316407.4062745	1.1e-37	162.2	Gammaproteobacteria													Escherichia	1P8S7@1224,1SW31@1236,294ER@1,2ZRUM@2	NA|NA|NA		
b1168	316407.85674859	6.3e-290	1002.7	Escherichia	ycgG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1N299@1224,1RNP4@1236,3XQT7@561,COG2200@1,COG2200@2	NA|NA|NA	T	cyclic-guanylate-specific phosphodiesterase activity
b4491	469008.B21_01153	3e-255	888.3	Bacteria													Escherichia	COG3468@1,COG3468@2	NA|NA|NA	MU	cell adhesion
b1171	198214.SF1158	4.5e-52	210.3	Gammaproteobacteria													Escherichia	1MZD0@1224,1SC09@1236,2E1DM@1,32WSV@2	NA|NA|NA	S	YmgD protein
b1172	199310.c1617	1.1e-16	92.8	Escherichia	ymgG												Escherichia	1N6AZ@1224,1SBA7@1236,2E2G4@1,32XK9@2,3XPUW@561	NA|NA|NA	S	Glycine-zipper domain
b4593	469008.B21_04308	4.8e-21	106.3	Escherichia	ymgI												Escherichia	1QGQ4@1224,1TE5B@1236,2ATGJ@1,31J08@2,3XRB8@561	NA|NA|NA		
b4521	316407.85674863	2.2e-14	85.1	Bacteria													Escherichia	COG3468@1,COG3468@2	NA|NA|NA	MU	cell adhesion
b1174	1440052.EAKF1_ch0279	5.5e-40	169.9	Escherichia	minE	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000918,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0007049,GO:0007346,GO:0008150,GO:0009987,GO:0010564,GO:0016020,GO:0016043,GO:0022402,GO:0022607,GO:0032465,GO:0032506,GO:0032954,GO:0032955,GO:0042802,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051726,GO:0061640,GO:0065007,GO:0071840,GO:0071944,GO:0090529,GO:1901891,GO:1902410,GO:1902412,GO:1903047,GO:1903436		ko:K03608					ko00000,ko03036,ko04812				Escherichia	1N6QD@1224,1SC8W@1236,3XPUI@561,COG0851@1,COG0851@2	NA|NA|NA	D	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
b1175	155864.EDL933_1867	8.6e-145	519.6	Escherichia	minD	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0007059,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051301,GO:0051302,GO:0051782,GO:0060187,GO:0065007,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363		ko:K03609					ko00000,ko03036,ko04812				Escherichia	1MUEU@1224,1RNJ0@1236,3XNRZ@561,COG2894@1,COG2894@2	NA|NA|NA	D	ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings
b1176	316407.1651575	1e-125	456.1	Escherichia	minC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007346,GO:0008150,GO:0009987,GO:0010564,GO:0032465,GO:0032954,GO:0032955,GO:0042802,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051726,GO:0060187,GO:0065007,GO:1901891,GO:1902412,GO:1903436		ko:K03610					ko00000,ko03036,ko04812				Escherichia	1RHVN@1224,1S6K8@1236,3XNRJ@561,COG0850@1,COG0850@2	NA|NA|NA	D	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization
b1177	316407.4062754	1e-65	255.8	Gammaproteobacteria													Escherichia	1RI8H@1224,1S9I8@1236,2BV6C@1,32QJR@2	NA|NA|NA	S	Fels-1 Prophage Protein-like
b1178	316407.4062755	2.7e-67	261.2	Escherichia	pliG	GO:0003674,GO:0004857,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030234,GO:0042597,GO:0043086,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0060241,GO:0065007,GO:0065009,GO:0098772											Escherichia	1N73H@1224,1SDSZ@1236,2C1UG@1,32ZD3@2,3XQ6I@561	NA|NA|NA	S	lysozyme inhibitor activity
b1179	199310.c1627	2.5e-55	221.1	Escherichia	ycgL			ko:K09902					ko00000				Escherichia	1N83J@1224,1SCCD@1236,3XPZD@561,COG3100@1,COG3100@2	NA|NA|NA	S	YcgL domain
b1180	316407.4062757	2.6e-123	448.0	Escherichia	ycgM												Escherichia	1MVFA@1224,1RN6Y@1236,3XNKX@561,COG0179@1,COG0179@2	NA|NA|NA	Q	metal ion binding
b1181	155864.EDL933_1875	2.6e-90	337.8	Escherichia	ycgN			ko:K09160					ko00000				Escherichia	1RHMX@1224,1S5XU@1236,3XPDK@561,COG2983@1,COG2983@2	NA|NA|NA	S	Putative zinc- or iron-chelating domain
b1182	316407.85674866	3.9e-162	577.4	Gammaproteobacteria													Escherichia	1R8QT@1224,1RS8N@1236,28N3N@1,2ZB9A@2	NA|NA|NA	O	Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells
b1183	155864.EDL933_1877	9.4e-71	272.7	Escherichia	umuD	GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009355,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0019985,GO:0031668,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990234		ko:K03503					ko00000,ko01000,ko01002,ko03400				Escherichia	1MZFA@1224,1S5X5@1236,3XPXS@561,COG1974@1,COG1974@2	NA|NA|NA	KT	Involved in UV protection and mutation. Poorly processive, error-prone DNA polymerase involved in translesion repair. Essential for induced (or SOS) mutagenesis. Able to replicate DNA across DNA lesions (thymine photodimers and abasic sites, called translesion synthesis) in the presence of activated RecA
b1184	316407.1651581	1.4e-245	855.1	Escherichia	umuC	GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003887,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009355,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0019985,GO:0031224,GO:0031668,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044425,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990234		ko:K03502					ko00000,ko03400				Escherichia	1MUUH@1224,1RMT1@1236,3XQ8B@561,COG0389@1,COG0389@2	NA|NA|NA	L	efficiency is maximal in the presence of the beta sliding-clamp and clamp-loading complex of DNA polymerase III plus single-stranded binding protein (SSB). RecA and to a lesser extent the beta clamp- complex may target Pol V to replication complexes stalled at DNA template lesions
b1185	316407.85674867	6.7e-98	363.2	Escherichia	dsbB	GO:0003674,GO:0003824,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0022900,GO:0044237,GO:0050896,GO:0055114		ko:K03611					ko00000,ko03110	5.A.2.1		iECED1_1282.ECED1_1327	Escherichia	1RIJE@1224,1S6WD@1236,3XN8V@561,COG1495@1,COG1495@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins
b1186	155864.EDL933_1880	1.7e-271	941.4	Escherichia	nhaB	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042592,GO:0044464,GO:0045851,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600		ko:K03314					ko00000,ko02000	2.A.34.1		iECP_1309.ECP_1229,iLF82_1304.LF82_1485,iNRG857_1313.NRG857_06055,iUTI89_1310.UTI89_C1372	Escherichia	1MV0F@1224,1RPE3@1236,3XNNA@561,COG3067@1,COG3067@2	NA|NA|NA	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
b1187	1440052.EAKF1_ch0265c	1.1e-135	489.2	Escherichia	fadR	GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019395,GO:0019752,GO:0030258,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032787,GO:0034440,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045723,GO:0045834,GO:0045892,GO:0045893,GO:0045923,GO:0045934,GO:0045935,GO:0046889,GO:0046890,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0055114,GO:0060255,GO:0062012,GO:0062013,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K03603					ko00000,ko03000				Escherichia	1MW7M@1224,1RMRE@1236,3XP0P@561,COG2186@1,COG2186@2	NA|NA|NA	K	Multifunctional regulator of fatty acid metabolism
b1188	316407.4062773	6.7e-308	1062.4	Escherichia	ycgB	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1MW6U@1224,1RPU2@1236,3XMG4@561,COG2719@1,COG2719@2	NA|NA|NA	S	cellular response to DNA damage stimulus
b1189	199310.c1638	1.4e-253	881.7	Escherichia	dadA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0008718,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019478,GO:0019480,GO:0019752,GO:0042851,GO:0042853,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055114,GO:0055130,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.5.1	ko:K00285	ko00360,map00360		R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000			iSBO_1134.SBO_1883,iSFV_1184.SFV_1196,iSF_1195.SF1178,iSFxv_1172.SFxv_1352,iS_1188.S1266,iUMNK88_1353.UMNK88_1502	Escherichia	1MVIZ@1224,1RQ50@1236,3XNX8@561,COG0665@1,COG0665@2	NA|NA|NA	E	Oxidative deamination of D-amino acids
b1190	316407.1651592	7.5e-205	719.5	Escherichia	dadX		5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502		R00401	RC00285	ko00000,ko00001,ko01000,ko01011			iEC55989_1330.EC55989_1285,iECIAI39_1322.ECIAI39_1880,iECO103_1326.ECO103_1292,iECO26_1355.ECO26_1703,iECSE_1348.ECSE_1238,iECUMN_1333.ECUMN_1479,iECW_1372.ECW_m1275,iEKO11_1354.EKO11_2666,iEcE24377_1341.EcE24377A_1335,iWFL_1372.ECW_m1275	Escherichia	1MV0Q@1224,1RM8U@1236,3XP41@561,COG0787@1,COG0787@2	NA|NA|NA	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
b1191	316407.85674868	0.0	1097.0	Escherichia	cvrA	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006884,GO:0008150,GO:0008324,GO:0008361,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071840,GO:0071944,GO:0090066,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600		ko:K11105					ko00000,ko02000	2.A.36.6			Escherichia	1MVKV@1224,1RMCA@1236,3XMWT@561,COG3263@1,COG3263@2	NA|NA|NA	P	) H( ) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels
b1192	316407.4062777	4.3e-177	627.1	Escherichia	ldcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009050,GO:0009056,GO:0009254,GO:0009987,GO:0016787,GO:0019538,GO:0030203,GO:0034641,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.4.17.13	ko:K01297					ko00000,ko01000,ko01002,ko01011			iAPECO1_1312.APECO1_304,iECABU_c1320.ECABU_c14580,iECED1_1282.ECED1_1334,iECOK1_1307.ECOK1_1338,iECS88_1305.ECS88_1255,iLF82_1304.LF82_1171,iNRG857_1313.NRG857_06085,iUMN146_1321.UM146_11125,iUTI89_1310.UTI89_C1378,ic_1306.c1641	Escherichia	1MWIY@1224,1RQT8@1236,3XMJ8@561,COG1619@1,COG1619@2	NA|NA|NA	V	Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso- Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc- anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross- linked muropeptides. The tripeptides produced by the LcdA reaction can then be reused as peptidoglycan building blocks
b1193	316407.85674869	4.2e-112	410.6	Escherichia	emtA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008932,GO:0008933,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0061783,GO:0071944		ko:K08308					ko00000,ko01000,ko01011		GH23	iAF1260.b1193,iB21_1397.B21_01178,iBWG_1329.BWG_1018,iECBD_1354.ECBD_2429,iECB_1328.ECB_01168,iECDH10B_1368.ECDH10B_1246,iECDH1ME8569_1439.ECDH1ME8569_1132,iECD_1391.ECD_01168,iEcDH1_1363.EcDH1_2455,iEcolC_1368.EcolC_2432,iJO1366.b1193,iUMNK88_1353.UMNK88_1507,iY75_1357.Y75_RS06225	Escherichia	1MWFU@1224,1RRJC@1236,3XP3G@561,COG0741@1,COG0741@2	NA|NA|NA	M	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain
b1194	316407.85674870	6.2e-134	483.4	Escherichia	ycgR	GO:0000166,GO:0001539,GO:0003674,GO:0005488,GO:0006928,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0035438,GO:0036094,GO:0040011,GO:0040012,GO:0043167,GO:0043168,GO:0048870,GO:0050789,GO:0050794,GO:0051179,GO:0051270,GO:0051674,GO:0065007,GO:0071945,GO:0071973,GO:0097159,GO:0097367,GO:0097588,GO:1901265,GO:1901363,GO:1902021,GO:2000145		ko:K21087	ko02026,map02026				ko00000,ko00001				Escherichia	1MX00@1224,1RY2F@1236,3XMYZ@561,COG5581@1,COG5581@2	NA|NA|NA	M	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
b1195	316407.4062780	4.1e-37	160.2	Escherichia	ymgE												Escherichia	1N72W@1224,1S8YP@1236,3XQ0Y@561,COG2261@1,COG2261@2	NA|NA|NA	S	Transglycosylase associated protein
b1196	316407.85674871	5.4e-77	293.5	Escherichia	ycgY												Escherichia	1NWE0@1224,1SPQA@1236,2CIJV@1,33XM0@2,3XR1U@561	NA|NA|NA		
b1197	316407.1651595	0.0	1170.2	Escherichia	treA	GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005575,GO:0005623,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009628,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071704,GO:0104004,GO:1901575	3.2.1.28	ko:K01194	ko00500,ko01100,map00500,map01100		R00010	RC00049	ko00000,ko00001,ko00537,ko01000		GH37	iAF1260.b1197,iB21_1397.B21_01182,iBWG_1329.BWG_1022,iECBD_1354.ECBD_2425,iECB_1328.ECB_01172,iECDH10B_1368.ECDH10B_1250,iECDH1ME8569_1439.ECDH1ME8569_1136,iECD_1391.ECD_01172,iECUMN_1333.ECUMN_1493,iETEC_1333.ETEC_1301,iEcDH1_1363.EcDH1_2451,iEcHS_1320.EcHS_A1301,iEcolC_1368.EcolC_2429,iJO1366.b1197,iJR904.b1197,iY75_1357.Y75_RS06245	Escherichia	1MWSM@1224,1RMFP@1236,3XMWX@561,COG1626@1,COG1626@2	NA|NA|NA	G	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
b1198	316407.85674872	2.8e-260	904.0	Escherichia	dhaM	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006476,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0018193,GO:0018205,GO:0019213,GO:0019538,GO:0033554,GO:0033558,GO:0034983,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0047324,GO:0050896,GO:0051716,GO:0071704,GO:0098732,GO:0140096,GO:1901564	2.7.1.121	ko:K05881	ko00561,map00561		R01012	RC00015,RC00017	ko00000,ko00001,ko01000,ko02000			iECs_1301.ECs1703,iSF_1195.SF1201,iS_1188.S1285,iUTI89_1310.UTI89_C1391,iZ_1308.Z1969	Escherichia	1MUT8@1224,1RRCZ@1236,3XN0F@561,COG1080@1,COG1080@2,COG1925@1,COG1925@2,COG3412@1,COG3412@2	NA|NA|NA	G	Protein deacetylase that removes acetyl groups on specific lysine residues in target proteins. Regulates transcription by catalyzing deacetylation of 'Lys-52' and 'Lys-62' of the transcriptional repressor RutR. Is also able to deacetylate NhoA and RluC in vitro. Targets a distinct set of substrates compared to CobB
b1199	316407.85674873	6.3e-111	406.8	Escherichia	dhaL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047324,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100		R01012	RC00015,RC00017	ko00000,ko00001,ko01000			iECUMN_1333.ECUMN_1495	Escherichia	1MXIB@1224,1RPJ7@1236,3XMTJ@561,COG1461@1,COG1461@2	NA|NA|NA	S	ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaL-ADP is converted to DhaL-ATP via a phosphoryl group transfer from DhaM and transmits it to dihydroxyacetone binds to DhaK. DhaL acts also as coactivator of the transcription activator DhaR by binding to the sensor domain of DhaR. In the presence of dihydroxyacetone, DhaL- ADP displaces DhaK and stimulates DhaR activity. In the absence of dihydroxyacetone, DhaL-ADP is converted by the PTS to DhaL-ATP, which does not bind to DhaR
b1200	316407.85674874	1e-206	725.7	Escherichia	dhaK	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019637,GO:0019751,GO:0033554,GO:0034308,GO:0042180,GO:0042182,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0047324,GO:0050896,GO:0051716,GO:0061610,GO:0071704,GO:1901135,GO:1901575,GO:1901615	2.7.1.121	ko:K05878	ko00561,ko01100,map00561,map01100		R01012	RC00015,RC00017	ko00000,ko00001,ko01000			iEcHS_1320.EcHS_A1304,iUMNK88_1353.UMNK88_1515	Escherichia	1MVSR@1224,1RNRQ@1236,3XP0J@561,COG2376@1,COG2376@2	NA|NA|NA	G	Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)- dependent phosphorylation of dihydroxyacetone via a phosphoryl group transfer from DhaL-ATP. Binds covalently dihydroxyacetone in hemiaminal linkage. DhaK acts also as corepressor of the transcription activator DhaR by binding to the sensor domain of DhaR. In the presence of dihydroxyacetone, DhaL-ADP displaces DhaK and stimulates DhaR activity. In the absence of dihydroxyacetone, DhaL-ADP is converted by the PTS to DhaL-ATP, which does not bind to DhaR
b1201	316407.85674875	0.0	1250.0	Escherichia	dhaR	GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K05880					ko00000,ko03000				Escherichia	1NRG5@1224,1RQQD@1236,3XPI9@561,COG3284@1,COG3284@2	NA|NA|NA	KQ	PTS-dependent dihydroxyacetone kinase operon regulatory protein
b1202	316407.85674876	0.0	1730.7	Gammaproteobacteria													Escherichia	1R3VW@1224,1RSKC@1236,COG3468@1,COG3468@2	NA|NA|NA	MU	cell adhesion involved in biofilm formation
b1203	155864.EDL933_1907	2e-205	721.5	Escherichia	ychF	GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772		ko:K06942					ko00000,ko03009				Escherichia	1MVM4@1224,1RMBI@1236,3XNGE@561,COG0012@1,COG0012@2	NA|NA|NA	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner
b1204	155864.EDL933_1908	2.7e-108	397.9	Escherichia	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019538,GO:0030163,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0052689,GO:0071704,GO:0140098,GO:0140101,GO:1901564,GO:1901565,GO:1901575	3.1.1.29	ko:K01056					ko00000,ko01000,ko03012				Escherichia	1MX1P@1224,1RPK3@1236,3XNIA@561,COG0193@1,COG0193@2	NA|NA|NA	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis
b1205	1440052.EAKF1_ch0242c	1.4e-46	191.8	Escherichia	ychH	GO:0000302,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044011,GO:0044764,GO:0046677,GO:0046686,GO:0050896,GO:0051703,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071236,GO:0071241,GO:0071248,GO:0071276,GO:0090605,GO:0090609,GO:0097237,GO:1901700,GO:1901701											Escherichia	1MZI6@1224,1S8Y3@1236,2DB54@1,32TWR@2,3XPVG@561	NA|NA|NA	S	cellular response to cadmium ion
b1206	155864.EDL933_1910	3.7e-275	953.7	Escherichia	ychM	GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039		ko:K03321					ko00000,ko02000	2.A.53.3		iSbBS512_1146.SbBS512_E1370	Escherichia	1MVWV@1224,1RMCN@1236,3XMAJ@561,COG0659@1,COG0659@2	NA|NA|NA	P	Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH. Can transport other C4-dicarboxylic acids such as aspartate and fumarate. May also play a role in the regulation of C4-dicarboxylic acid metabolism at pH 7, via regulation of expression and or activity of DctA. May act as a co-sensor of DcuS
b1207	199310.c1665	4.3e-172	610.5	Escherichia	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0042301,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000			iAF1260.b1207,iAPECO1_1312.APECO1_323,iB21_1397.B21_01192,iBWG_1329.BWG_1032,iE2348C_1286.E2348C_1330,iEC042_1314.EC042_1264,iEC55989_1330.EC55989_1303,iECABU_c1320.ECABU_c14780,iECBD_1354.ECBD_2414,iECB_1328.ECB_01182,iECDH10B_1368.ECDH10B_1260,iECDH1ME8569_1439.ECDH1ME8569_1146,iECD_1391.ECD_01182,iECED1_1282.ECED1_1355,iECH74115_1262.ECH74115_1688,iECIAI1_1343.ECIAI1_1228,iECIAI39_1322.ECIAI39_1543,iECNA114_1301.ECNA114_1372,iECO103_1326.ECO103_1309,iECO111_1330.ECO111_1536,iECO26_1355.ECO26_1720,iECOK1_1307.ECOK1_1360,iECP_1309.ECP_1255,iECS88_1305.ECS88_1275,iECSE_1348.ECSE_1257,iECSF_1327.ECSF_1183,iECSP_1301.ECSP_1597,iECUMN_1333.ECUMN_1504,iECW_1372.ECW_m1293,iECs_1301.ECs1712,iEKO11_1354.EKO11_2647,iETEC_1333.ETEC_1311,iEcDH1_1363.EcDH1_2440,iEcE24377_1341.EcE24377A_1355,iEcHS_1320.EcHS_A1312,iEcSMS35_1347.EcSMS35_1935,iEcolC_1368.EcolC_2419,iG2583_1286.G2583_1478,iJO1366.b1207,iJR904.b1207,iLF82_1304.LF82_1744,iNRG857_1313.NRG857_06180,iSBO_1134.SBO_1860,iSDY_1059.SDY_1256,iSSON_1240.SSON_1971,iUMN146_1321.UM146_11025,iUMNK88_1353.UMNK88_1523,iUTI89_1310.UTI89_C1401,iWFL_1372.ECW_m1293,iY75_1357.Y75_RS06300,ic_1306.c1665	Escherichia	1MW21@1224,1RMUC@1236,3XP2G@561,COG0462@1,COG0462@2	NA|NA|NA	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
b1208	155864.EDL933_1912	1.1e-161	575.9	Escherichia	ispE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0050515,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_1304	Escherichia	1MVU3@1224,1RP23@1236,3XN5B@561,COG1947@1,COG1947@2	NA|NA|NA	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
b1209	155864.EDL933_1913	3.1e-118	431.0	Escherichia	lolB	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564		ko:K02494					ko00000				Escherichia	1N02T@1224,1S91E@1236,3XNXQ@561,COG3017@1,COG3017@2	NA|NA|NA	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
b1210	155864.EDL933_1914	1.3e-224	785.4	Escherichia	hemA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000			iUTI89_1310.UTI89_C1404	Escherichia	1MU41@1224,1RNQ8@1236,3XMMM@561,COG0373@1,COG0373@2	NA|NA|NA	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
b1211	155864.EDL933_1915	2.6e-197	694.5	Escherichia	prfA	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02835					ko00000,ko03012				Escherichia	1MV28@1224,1RM7Q@1236,3XN9G@561,COG0216@1,COG0216@2	NA|NA|NA	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
b1212	198214.SF1215	2e-152	545.0	Gammaproteobacteria													Escherichia	1MXCQ@1224,1RNGK@1236,COG2890@1,COG2890@2	NA|NA|NA	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif
b1213	316407.4062792	5.2e-63	246.9	Escherichia	ychQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MZN6@1224,1S5WP@1236,3XPST@561,COG3094@1,COG3094@2	NA|NA|NA	S	Invasion gene expression up-regulator, SirB
b1214	155864.EDL933_1918	4.7e-151	540.4	Escherichia	ychA												Escherichia	1MVJQ@1224,1RQ7V@1236,3XP28@561,COG2912@1,COG2912@2	NA|NA|NA	S	Transglutaminase-like superfamily
b1215	198214.SF1218	4.9e-159	567.0	Gammaproteobacteria													Escherichia	1MV91@1224,1RMGQ@1236,COG2877@1,COG2877@2	NA|NA|NA	M	Belongs to the KdsA family
b4419	155864.EDL933_1920	1.2e-11	74.3	Escherichia													Escherichia	1QIT0@1224,1TGNC@1236,2AWZ3@1,31NWV@2,3XRD7@561	NA|NA|NA	S	Toxin Ldr, type I toxin-antitoxin system
b4421	155864.EDL933_1921	1.5e-12	77.4	Escherichia				ko:K18862					ko00000,ko02048				Escherichia	1QIT0@1224,1TGNC@1236,2AWZ3@1,31NWV@2,3XRD7@561	NA|NA|NA	S	Toxin Ldr, type I toxin-antitoxin system
b4423	155864.EDL933_1920	1.2e-11	74.3	Escherichia													Escherichia	1QIT0@1224,1TGNC@1236,2AWZ3@1,31NWV@2,3XRD7@561	NA|NA|NA	S	Toxin Ldr, type I toxin-antitoxin system
b1216	316407.1651604	4.1e-182	644.0	Escherichia	chaA	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035725,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600		ko:K07300					ko00000,ko02000	2.A.19		iB21_1397.B21_01204,iEC55989_1330.EC55989_1314,iECBD_1354.ECBD_2403,iECB_1328.ECB_01194,iECD_1391.ECD_01194,iECIAI1_1343.ECIAI1_1238,iECO103_1326.ECO103_1321,iECO111_1330.ECO111_1548,iECO26_1355.ECO26_1732,iECSE_1348.ECSE_1269,iECW_1372.ECW_m1308,iETEC_1333.ETEC_1322,iEcE24377_1341.EcE24377A_1366,iEcHS_1320.EcHS_A1324,iEcolC_1368.EcolC_2407,iSSON_1240.SSON_1961,iSbBS512_1146.SbBS512_E1383,iUMNK88_1353.UMNK88_1535,iWFL_1372.ECW_m1308	Escherichia	1MWD8@1224,1RME3@1236,3XM80@561,COG0387@1,COG0387@2	NA|NA|NA	P	proton antiporter
b1217	155864.EDL933_1923	4.9e-37	159.8	Escherichia	chaB			ko:K06197					ko00000				Escherichia	1N93H@1224,1S94E@1236,3XPYK@561,COG4572@1,COG4572@2	NA|NA|NA	K	Might be a regulator of the sodium-potassium proton antiporter ChaA
b1218	316407.1651606	8.4e-133	479.6	Escherichia	chaC	GO:0001539,GO:0003674,GO:0003824,GO:0003839,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006751,GO:0006790,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0034641,GO:0040011,GO:0042219,GO:0043171,GO:0043603,GO:0044237,GO:0044248,GO:0044273,GO:0044424,GO:0044464,GO:0048870,GO:0051179,GO:0051186,GO:0051187,GO:0051674,GO:0071704,GO:0071973,GO:0097588,GO:1901564,GO:1901565,GO:1901575		ko:K07232					ko00000				Escherichia	1QA7D@1224,1S2MT@1236,3XMMU@561,COG3703@1,COG3703@2	NA|NA|NA	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
b1219	155864.EDL933_1925	1.6e-58	231.9	Escherichia	ychN	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0034214,GO:0042802,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051259,GO:0065003,GO:0071840		ko:K06039					ko00000				Escherichia	1RDFR@1224,1S3RB@1236,3XPQV@561,COG1553@1,COG1553@2	NA|NA|NA	P	protein hexamerization
b1220	511145.b1220	1.8e-251	874.8	Escherichia	ychO	GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009405,GO:0016020,GO:0019867,GO:0030260,GO:0030312,GO:0030313,GO:0031975,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944											Escherichia	1QU9Z@1224,1T1R3@1236,3XN7F@561,COG4932@1,COG4932@2	NA|NA|NA	M	entry into host
b1221	155864.EDL933_1927	1.5e-112	412.1	Escherichia	narL	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0090352,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903314,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K07684	ko02020,map02020	M00471			ko00000,ko00001,ko00002,ko02022				Escherichia	1NQH7@1224,1RNXI@1236,3XM5F@561,COG2197@1,COG2197@2	NA|NA|NA	K	This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate nitrite induction signal transmitted by either the NarX or NarQ proteins
b1222	155864.EDL933_1928	4.8e-305	1053.1	Escherichia	narX	GO:0000155,GO:0000160,GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071250,GO:0071704,GO:0071944,GO:0080033,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	2.7.13.3	ko:K07673	ko02020,map02020	M00471			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1MWZT@1224,1RNPP@1236,3XMF0@561,COG3850@1,COG3850@2	NA|NA|NA	T	Acts as a sensor for nitrate nitrite and transduces signal of nitrate availability to the NarL protein and of both nitrate nitrite to the NarP protein. NarX probably activates NarL and NarP by phosphorylation in the presence of nitrate. NarX also plays a negative role in controlling NarL activity, probably through dephosphorylation in the absence of nitrate
b1223	316407.1651617	7.3e-261	906.0	Escherichia	narK	GO:0003674,GO:0005215,GO:0005452,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656		ko:K02575	ko00910,map00910	M00615			ko00000,ko00001,ko00002,ko02000	2.A.1.8		iUTI89_1310.UTI89_C1420	Escherichia	1MU27@1224,1RMUK@1236,3XPED@561,COG2223@1,COG2223@2	NA|NA|NA	P	Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. Functions as a nitrate nitrite exchanger, and protons are probably not co- transported with the substrate
b1224	316407.4062800	0.0	2611.6	Escherichia	narG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0022900,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0042126,GO:0043436,GO:0043546,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204,GO:2001057	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1		iSBO_1134.SBO_1842	Escherichia	1MW9S@1224,1RQ27@1236,3XPE4@561,COG5013@1,COG5013@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
b1225	316407.1651621	0.0	1077.8	Escherichia	narH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0022900,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0042126,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204,GO:2001057	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1		iEcE24377_1341.EcE24377A_1376	Escherichia	1MW9Q@1224,1RNMJ@1236,3XMWG@561,COG1140@1,COG1140@2	NA|NA|NA	C	The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit
b1226	155864.EDL933_1933	1.9e-127	461.8	Escherichia	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057		ko:K00373	ko02020,map02020				ko00000,ko00001			iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,ic_1306.c1687	Escherichia	1MY4E@1224,1RQ23@1236,3XMJW@561,COG2180@1,COG2180@2	NA|NA|NA	C	Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase 1. Required for the insertion of the molybdenum into the apo-NarG subunit, maybe by keeping NarG in an appropriate competent-open conformation for the molybdenum cofactor insertion to occur. NarJ maintains the apoNarGH complex in a soluble state. Upon insertion of the molybdenum cofactor, NarJ seems to dissociate from the activated soluble NarGH complex, before its association with the NarI subunit on the membrane
b1227	316407.1651623	1.8e-124	451.8	Escherichia	narI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1		iSF_1195.SF1230	Escherichia	1MXGZ@1224,1RPTD@1236,3XM94@561,COG2181@1,COG2181@2	NA|NA|NA	C	The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit
b1232	316407.1651625	2.2e-159	568.2	Escherichia	purU	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006753,GO:0006760,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008864,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009256,GO:0009257,GO:0009259,GO:0009260,GO:0009396,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0034641,GO:0034654,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670		R00944	RC00026,RC00111	ko00000,ko00001,ko01000			iSDY_1059.SDY_1284	Escherichia	1MVCF@1224,1RN6Q@1236,3XN6P@561,COG0788@1,COG0788@2	NA|NA|NA	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)
b1233	316407.4062802	1.5e-90	338.6	Escherichia	ychJ			ko:K09858					ko00000				Escherichia	1MZZK@1224,1S9FV@1236,3XPSS@561,COG3012@1,COG3012@2	NA|NA|NA	S	Belongs to the UPF0225 family
b1234	198214.SF1234	8.6e-170	602.8	Gammaproteobacteria													Escherichia	1MUM9@1224,1RRA1@1236,COG1752@1,COG1752@2	NA|NA|NA	M	esterase of the alpha-beta hydrolase superfamily
b1235	155864.EDL933_1938	6.4e-190	669.8	Escherichia	rssB	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0009893,GO:0010556,GO:0010604,GO:0016989,GO:0019219,GO:0019222,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031647,GO:0031648,GO:0032268,GO:0032270,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0140110,GO:1903506,GO:2001141		ko:K02485					ko00000,ko02022				Escherichia	1R3UE@1224,1RRJX@1236,3XP2A@561,COG0745@1,COG0745@2	NA|NA|NA	KT	Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation
b1236	155864.EDL933_1939	2.1e-168	598.2	Escherichia	galU	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003983,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006011,GO:0006012,GO:0006073,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009056,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009242,GO:0009244,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016052,GO:0016740,GO:0016772,GO:0016779,GO:0019318,GO:0019320,GO:0019388,GO:0022607,GO:0033499,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046401,GO:0046483,GO:0046872,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051748,GO:0055086,GO:0065003,GO:0070569,GO:0071704,GO:0071840,GO:1900725,GO:1900727,GO:1901135,GO:1901137,GO:1901360,GO:1901575,GO:1901576,GO:1903509	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_1571	Escherichia	1MV5F@1224,1RNDX@1236,3XNPY@561,COG1210@1,COG1210@2	NA|NA|NA	M	May play a role in stationary phase survival
b1237	155864.EDL933_1940	1.4e-55	222.2	Escherichia	hns	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0042802,GO:0043565,GO:0043900,GO:0043901,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1900190,GO:1900191,GO:1900231,GO:1900232,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K03746					ko00000,ko03036,ko03400				Escherichia	1R9YM@1224,1S24H@1236,3XPMF@561,COG2916@1,COG2916@2	NA|NA|NA	K	A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher- order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity)
b1238	316407.1651638	1.5e-112	412.1	Escherichia	tdk	GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100		R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000			iAF1260.b1238,iBWG_1329.BWG_1065,iECDH10B_1368.ECDH10B_1298,iECDH1ME8569_1439.ECDH1ME8569_1176,iEcDH1_1363.EcDH1_2411,iJO1366.b1238,iJR904.b1238,iY75_1357.Y75_RS06470	Escherichia	1NJR4@1224,1RPCK@1236,3XPH5@561,COG1435@1,COG1435@2	NA|NA|NA	F	thymidine kinase
b4573	637910.ROD_02711	3.9e-106	391.3	Gammaproteobacteria													Escherichia	1MVRM@1224,1RRFT@1236,COG3385@1,COG3385@2	NA|NA|NA	L	COG3385 FOG Transposase and inactivated derivatives
b1241	155864.EDL933_1943	0.0	1737.2	Escherichia	adhE	GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006067,GO:0006115,GO:0008150,GO:0008152,GO:0008774,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0016620,GO:0016903,GO:0016999,GO:0017000,GO:0017144,GO:0034308,GO:0034309,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0055114,GO:0071704,GO:1901576,GO:1901615,GO:1901617	1.1.1.1,1.2.1.10	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220		R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000			iEcE24377_1341.EcE24377A_1389	Escherichia	1MVPH@1224,1RNBH@1236,3XMER@561,COG1012@1,COG1012@2,COG1454@1,COG1454@2	NA|NA|NA	C	This enzyme has three activities ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction
b1242	316407.85674882	5.5e-110	403.7	Escherichia	ychE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MX5T@1224,1RPZ3@1236,3XPFF@561,COG2095@1,COG2095@2	NA|NA|NA	U	Membrane
b4711	316407.1736552	5.6e-194	683.3	Gammaproteobacteria													Escherichia	1MVDK@1224,1RR0T@1236,COG3039@1,COG3039@2	NA|NA|NA	L	COG3039 Transposase and inactivated derivatives IS5 family
b1243	316407.85674884	0.0	1110.9	Escherichia	oppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750		ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iECABU_c1320.ECABU_c15240,iECNA114_1301.ECNA114_1414,iECSF_1327.ECSF_1224,iNRG857_1313.NRG857_06385	Escherichia	1P91R@1224,1RN57@1236,3XMGQ@561,COG4166@1,COG4166@2	NA|NA|NA	E	periplasmic oligopeptide-binding protein
b1244	155864.EDL933_1948	2.8e-152	544.7	Escherichia	oppB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25			Escherichia	1MU8Z@1224,1RNJ1@1236,3XNE6@561,COG0601@1,COG0601@2	NA|NA|NA	EP	probably responsible for the translocation of the substrate across the membrane
b1245	316407.1742034	2.4e-143	515.0	Escherichia	oppC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iAF1260.b1245,iB21_1397.B21_01229,iEC55989_1330.EC55989_1342,iECBD_1354.ECBD_2377,iECB_1328.ECB_01219,iECDH10B_1368.ECDH10B_1307,iECDH1ME8569_1439.ECDH1ME8569_1185,iECD_1391.ECD_01219,iECIAI1_1343.ECIAI1_1264,iECO103_1326.ECO103_1345,iECO111_1330.ECO111_1572,iECO26_1355.ECO26_1756,iECSE_1348.ECSE_1293,iECSP_1301.ECSP_1637,iECUMN_1333.ECUMN_1542,iECW_1372.ECW_m1337,iECs_1301.ECs1745,iEKO11_1354.EKO11_2607,iETEC_1333.ETEC_1347,iEcDH1_1363.EcDH1_2403,iEcE24377_1341.EcE24377A_1393,iEcHS_1320.EcHS_A1354,iEcolC_1368.EcolC_2383,iG2583_1286.G2583_1517,iJO1366.b1245,iSSON_1240.SSON_1935,iUMNK88_1353.UMNK88_1565,iWFL_1372.ECW_m1337,iY75_1357.Y75_RS06515,iZ_1308.Z2021	Escherichia	1MU26@1224,1RND6@1236,3XMVD@561,COG1173@1,COG1173@2	NA|NA|NA	EP	Oligopeptide transport system permease protein OppC
b1246	316407.1742035	3e-187	661.0	Escherichia	oppD	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iECED1_1282.ECED1_1398,iLF82_1304.LF82_1573,iSBO_1134.SBO_1821	Escherichia	1R4KB@1224,1SMBI@1236,3XMHZ@561,COG0444@1,COG0444@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
b1247	316407.1742036	3.6e-193	680.6	Escherichia	oppF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iAPECO1_1312.APECO1_362,iECOK1_1307.ECOK1_1402,iECS88_1305.ECS88_1315,iUMN146_1321.UM146_10835,iUTI89_1310.UTI89_C1445	Escherichia	1NU4K@1224,1SKPD@1236,3XP3N@561,COG4608@1,COG4608@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
b1248	155864.EDL933_1952	4.7e-57	226.9	Escherichia	yciU			ko:K09901					ko00000				Escherichia	1RE1F@1224,1S43E@1236,3XPP5@561,COG3099@1,COG3099@2	NA|NA|NA	S	Belongs to the UPF0263 family
b1249	199310.c1713	2.5e-280	970.7	Escherichia	cls	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576		ko:K06131	ko00564,ko01100,map00564,map01100		R07390	RC00017	ko00000,ko00001,ko01000			iSDY_1059.SDY_1307	Escherichia	1MWUW@1224,1RPQG@1236,3XMEC@561,COG1502@1,COG1502@2	NA|NA|NA	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
b4595	199310.c1714	9.7e-22	108.6	Escherichia	yciY												Escherichia	1N7PT@1224,1SCYM@1236,2EAF9@1,334IP@2,3XQ47@561	NA|NA|NA		
b1250	316407.1742039	3.8e-224	783.9	Escherichia	kch	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055085,GO:0065003,GO:0071804,GO:0071805,GO:0071840,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K10716					ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6		iEC042_1314.EC042_1304,iECUMN_1333.ECUMN_1549	Escherichia	1R3QQ@1224,1RPFS@1236,3XNGG@561,COG1226@1,COG1226@2	NA|NA|NA	P	Potassium channel
b1251	198214.SF1254	2.3e-47	194.5	Gammaproteobacteria													Escherichia	1MZ9Z@1224,1S8UC@1236,COG2350@1,COG2350@2	NA|NA|NA	T	YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the
b1252	316407.85674886	3.4e-68	265.0	Escherichia	tonB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0007154,GO:0007165,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0015688,GO:0015833,GO:0015889,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0016032,GO:0019058,GO:0019062,GO:0019904,GO:0022610,GO:0023052,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0031992,GO:0032991,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0042914,GO:0043213,GO:0044403,GO:0044406,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0044650,GO:0046813,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0051704,GO:0051716,GO:0060089,GO:0065007,GO:0071575,GO:0071702,GO:0071705,GO:0071944,GO:0098002,GO:0098552,GO:0098670,GO:0098796,GO:0098797,GO:1901678		ko:K03832					ko00000,ko02000	2.C.1.1		iAPECO1_1312.APECO1_368,iEC55989_1330.EC55989_1350,iECABU_c1320.ECABU_c15340,iECNA114_1301.ECNA114_1423,iECO103_1326.ECO103_1353,iECP_1309.ECP_1300,iECSF_1327.ECSF_1233,iEcE24377_1341.EcE24377A_1410	Escherichia	1MXBE@1224,1RMI4@1236,3XNNV@561,COG0810@1,COG0810@2	NA|NA|NA	U	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
b1253	198214.SF1256	3.8e-69	267.3	Gammaproteobacteria													Escherichia	1MZAZ@1224,1SA9N@1236,COG1607@1,COG1607@2	NA|NA|NA	I	acyl-CoA thioester hydrolase
b1254	155864.EDL933_1958	2.2e-80	305.1	Escherichia	ispZ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K06190					ko00000				Escherichia	1NWIZ@1224,1RQAB@1236,3XM6E@561,COG2917@1,COG2917@2	NA|NA|NA	D	probably involved in intracellular septation
b1255	316407.1742044	1.4e-117	429.1	Escherichia	yciC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1PYD0@1224,1RQC3@1236,28JC8@1,2Z96Y@2,3XM32@561	NA|NA|NA	S	Uncharacterised protein family (UPF0259)
b1256	198214.SF1259	2.9e-119	434.5	Gammaproteobacteria													Escherichia	1NUZJ@1224,1RRRC@1236,COG3047@1,COG3047@2	NA|NA|NA	M	outer membrane protein W
b1257	316407.1742046	8.7e-87	326.2	Escherichia	yciE	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1R4MJ@1224,1RRW4@1236,3XPRR@561,COG3685@1,COG3685@2	NA|NA|NA	S	cellular response to DNA damage stimulus
b1258	316407.1742047	3.5e-80	304.3	Escherichia	yciF	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1REKN@1224,1S45E@1236,3XPTQ@561,COG3685@1,COG3685@2	NA|NA|NA	S	cellular response to DNA damage stimulus
b1260	198214.SF1263	5.4e-147	526.9	Gammaproteobacteria													Escherichia	1MXJV@1224,1RMGN@1236,COG0159@1,COG0159@2	NA|NA|NA	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
b1261	198214.SF1264	2.8e-229	800.8	Gammaproteobacteria													Escherichia	1MUS8@1224,1RP4D@1236,COG0133@1,COG0133@2	NA|NA|NA	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
b1262	511145.b1262	1.4e-256	891.7	Escherichia	trpC	GO:0000162,GO:0003674,GO:0003824,GO:0004425,GO:0004640,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48,5.3.1.24	ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000			iSBO_1134.SBO_1804,iSDY_1059.SDY_1330	Escherichia	1MW5K@1224,1RNYH@1236,3XNN3@561,COG0134@1,COG0134@2,COG0135@1,COG0135@2	NA|NA|NA	E	Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain
b1263	316407.1742056	9.8e-302	1042.0	Escherichia	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.4.2.18,4.1.3.27	ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000			iSBO_1134.SBO_1803,iSbBS512_1146.SbBS512_E1488	Escherichia	1MUPV@1224,1RNXV@1236,3XMT6@561,COG0512@1,COG0512@2,COG0547@1,COG0547@2	NA|NA|NA	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
b1264	316407.1742057	2.4e-297	1027.3	Escherichia	trpE	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000			iG2583_1286.G2583_1603	Escherichia	1MVBJ@1224,1RMSE@1236,3XP2S@561,COG0147@1,COG0147@2	NA|NA|NA	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
b1266	316407.1742058	1.3e-170	605.5	Escherichia	trpH	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004534,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006521,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008409,GO:0009987,GO:0010565,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016796,GO:0016895,GO:0016896,GO:0019222,GO:0030145,GO:0031323,GO:0033238,GO:0034641,GO:0035312,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090357,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360	3.1.3.97	ko:K07053			R00188,R11188	RC00078	ko00000,ko01000				Escherichia	1MWIH@1224,1RNCG@1236,3XNVX@561,COG0613@1,COG0613@2	NA|NA|NA	S	Efficiently catalyzes the hydrolysis of the 3'-phosphate from 3',5'-bis-phosphonucleotides as well as the successive hydrolysis of 5'-phosphomononucleotides from the 5'-end of short pieces of RNA and DNA, with no specificity toward the identity of the nucleotide base. Is more efficient at hydrolyzing RNA oligonucleotides than DNA oligonucleotides. This enzyme can also hydrolyze annealed DNA duplexes, albeit at a catalytic efficiency approximately 10-fold lower than that of the corresponding single- stranded oligonucleotides
b1267	155864.EDL933_2425	3.2e-115	421.0	Escherichia	yciO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MVPM@1224,1RNU8@1236,3XNT1@561,COG0009@1,COG0009@2	NA|NA|NA	J	Belongs to the SUA5 family
b1268	316407.85674891	0.0	1263.8	Escherichia	yciQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MXPY@1224,1RQUG@1236,3XQ96@561,COG4907@1,COG4907@2	NA|NA|NA	S	Predicted membrane protein (DUF2207)
b1269	316407.1742064	3.4e-163	580.9	Escherichia	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.22	ko:K06178					ko00000,ko01000,ko03009				Escherichia	1MUCE@1224,1RQU0@1236,3XPCZ@561,COG1187@1,COG1187@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 2605 in 23S ribosomal RNA
b1270	199310.c1735	4e-107	394.0	Escherichia	btuR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008817,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019250,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000			iAF1260.b1270,iB21_1397.B21_01256,iBWG_1329.BWG_1099,iECABU_c1320.ECABU_c15500,iECBD_1354.ECBD_2352,iECB_1328.ECB_01246,iECDH10B_1368.ECDH10B_1385,iECDH1ME8569_1439.ECDH1ME8569_1209,iECD_1391.ECD_01246,iECIAI1_1343.ECIAI1_1288,iECO111_1330.ECO111_1649,iECO26_1355.ECO26_1834,iETEC_1333.ETEC_1372,iEcDH1_1363.EcDH1_2379,iEcHS_1320.EcHS_A1379,iJO1366.b1270,iJR904.b1270,iLF82_1304.LF82_0253,iNRG857_1313.NRG857_06515,iUMNK88_1353.UMNK88_1599,iY75_1357.Y75_RS06640,ic_1306.c1735	Escherichia	1MUN6@1224,1RMH9@1236,3XMRV@561,COG2109@1,COG2109@2	NA|NA|NA	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
b1271	316407.1742066	3.4e-143	514.2	Escherichia	yciK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575											Escherichia	1MWBC@1224,1RNNV@1236,3XMBX@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	organic substance catabolic process
b1272	198214.SF1274	3.1e-171	607.8	Gammaproteobacteria													Escherichia	1MUXE@1224,1RNN9@1236,COG0616@1,COG0616@2	NA|NA|NA	OU	peptidase
b1273	1440052.EAKF1_ch0161	1.1e-39	168.7	Escherichia	yciN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N8PV@1224,1S938@1236,2CK10@1,32SBA@2,3XPUN@561	NA|NA|NA	S	Protein of unknown function (DUF2498)
b1274	155864.EDL933_2418	0.0	1712.6	Escherichia	topA	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03168					ko00000,ko01000,ko03032,ko03400				Escherichia	1MUFZ@1224,1RNZ2@1236,3XMWC@561,COG0550@1,COG0550@2	NA|NA|NA	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
b1275	155864.EDL933_2417	1.2e-182	645.6	Escherichia	cysB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363		ko:K13634					ko00000,ko03000				Escherichia	1MU8N@1224,1RN7T@1236,3XMHJ@561,COG0583@1,COG0583@2	NA|NA|NA	K	This protein is a positive regulator of gene expression for the cysteine regulon
b4522	198214.SF1278	2.2e-23	114.0	Gammaproteobacteria													Escherichia	1NMDD@1224,1SGH3@1236,2EM1Z@1,33ERG@2	NA|NA|NA		
b4523	469008.B21_01263	3.8e-23	113.2	Escherichia													Escherichia	1NICF@1224,1SHXE@1236,2EUTS@1,33N9B@2,3XR9P@561	NA|NA|NA		
b1276	511145.b1276	0.0	1806.6	Escherichia	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_436,iECOK1_1307.ECOK1_1491,iECS88_1305.ECS88_1416,iUMN146_1321.UM146_10390,iUTI89_1310.UTI89_C1547	Escherichia	1MU9T@1224,1RN5I@1236,3XNZ5@561,COG1048@1,COG1048@2	NA|NA|NA	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
b1277	155864.EDL933_2413	6.5e-110	403.3	Escherichia	ribA	GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_437,iSbBS512_1146.SbBS512_E1505,iUTI89_1310.UTI89_C1548	Escherichia	1MWZR@1224,1RMFX@1236,3XM8V@561,COG0807@1,COG0807@2	NA|NA|NA	F	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
b1278	155864.EDL933_2412	2.6e-143	514.6	Escherichia	pgpB	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0016021,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019637,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0034645,GO:0042546,GO:0042578,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044425,GO:0044459,GO:0044462,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0050380,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K01096	ko00564,ko01100,map00564,map01100		R02029	RC00017	ko00000,ko00001,ko01000			iEC042_1314.EC042_1403,iECUMN_1333.ECUMN_1580	Escherichia	1MWW4@1224,1RNSB@1236,3XPD6@561,COG0671@1,COG0671@2	NA|NA|NA	I	Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are higher in the outer membrane. Activity is independent of a divalent cation ion and insensitive to inhibition by N- ethylmaleimide
b1279	198214.SF1283	2.2e-45	188.0	Gammaproteobacteria													Escherichia	1MZGX@1224,1S9X9@1236,COG3771@1,COG3771@2	NA|NA|NA	S	Involved in the assembly of lipopolysaccharide (LPS)
b1280	155864.EDL933_2410	4.9e-218	763.5	Escherichia	lapB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008653,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1903509		ko:K19804					ko00000				Escherichia	1MVDP@1224,1RP29@1236,3XNQF@561,COG2956@1,COG2956@2	NA|NA|NA	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
b1281	316407.1742095	2.2e-131	474.9	Escherichia	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,ic_1306.c1750	Escherichia	1MW2C@1224,1RNJR@1236,3XPD8@561,COG0284@1,COG0284@2	NA|NA|NA	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)
b1282	316407.1742096	1.8e-53	214.9	Escherichia	yciH	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043024,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K03113	ko03013,map03013				ko00000,ko00001,ko03012				Escherichia	1MZ8T@1224,1S929@1236,3XPU0@561,COG0023@1,COG0023@2	NA|NA|NA	J	cap-independent translational initiation of linear mRNA
b1283	155864.EDL933_2406	2.3e-28	131.0	Escherichia	osmB			ko:K04062					ko00000				Escherichia	1N0HV@1224,1S93Y@1236,2CMW8@1,32SFP@2,3XPYH@561	NA|NA|NA	M	Provides resistance to osmotic stress. May be important for stationary-phase survival
b1284	316407.85674892	7.5e-135	486.5	Escherichia	yciT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Escherichia	1MV49@1224,1RRR5@1236,3XM3W@561,COG1349@1,COG1349@2	NA|NA|NA	K	Transcriptional regulator
b4596	199310.c1755	1.3e-23	114.8	Escherichia	yciZ												Escherichia	1ND39@1224,1SCW0@1236,2E3CA@1,32YBK@2,3XQ4C@561	NA|NA|NA	S	Belongs to the UPF0509 family
b1285	316407.1742099	0.0	1305.8	Escherichia	gmr	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0008081,GO:0008150,GO:0010468,GO:0010608,GO:0016787,GO:0016788,GO:0017076,GO:0019001,GO:0019222,GO:0031279,GO:0031280,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0042578,GO:0043086,GO:0043167,GO:0043168,GO:0044092,GO:0050789,GO:0050790,GO:0060255,GO:0065007,GO:0065009,GO:0071111,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.1.4.52	ko:K14051	ko02024,ko02026,map02024,map02026				ko00000,ko00001,ko01000				Escherichia	1MU2C@1224,1RM8A@1236,3XPH6@561,COG5001@1,COG5001@2	NA|NA|NA	T	Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC ymaD and adrA (yaic). Activity of this protein is antagonized by the diguanylate cyclase YdaM. In vitro has c-di-GMP phosphodiesterase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
b1286	316407.1742100	0.0	1298.5	Escherichia	rnb	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	3.1.13.1	ko:K01147					ko00000,ko01000,ko03016				Escherichia	1P563@1224,1RP5G@1236,3XN7V@561,COG4776@1,COG4776@2	NA|NA|NA	J	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
b1287	316407.85674893	2.9e-215	754.2	Escherichia	yciW												Escherichia	1PBP5@1224,1RN1H@1236,3XMXK@561,COG2128@1,COG2128@2,COG4950@1,COG4950@2	NA|NA|NA	S	protein conserved in bacteria
b1288	155864.EDL933_2400	7.8e-143	513.1	Escherichia	fabI	GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0034641,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004			iECUMN_1333.ECUMN_1592	Escherichia	1MV05@1224,1RNMW@1236,3XPE3@561,COG0623@1,COG0623@2	NA|NA|NA	I	Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis
b1289	316407.1742102	1.5e-61	241.9	Gammaproteobacteria													Escherichia	1N0QU@1224,1S8Z3@1236,COG2852@1,COG2852@2	NA|NA|NA	S	Protein of unknown function (DUF559)
b1290	198214.SF1295	1.6e-146	525.4	Gammaproteobacteria													Escherichia	1MU09@1224,1RMEI@1236,COG1123@1,COG4172@2	NA|NA|NA	P	ATPase activity
b1291	155864.EDL933_2393	3.6e-193	680.6	Escherichia	sapD	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008144,GO:0008150,GO:0008324,GO:0008519,GO:0009987,GO:0015075,GO:0015101,GO:0015203,GO:0015489,GO:0015672,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0017076,GO:0022857,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071804,GO:0071805,GO:0072488,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1902047		ko:K19229	ko01503,ko02010,map01503,map02010	M00739			ko00000,ko00001,ko00002,ko02000	3.A.1.5.5			Escherichia	1MU09@1224,1RMEI@1236,3XNRN@561,COG1123@1,COG4172@2	NA|NA|NA	P	Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. Stimulates K( )-uptake proteins TrkG and TrkH to import K( ), may act via ATP-binding rather than ATP hydrolysis
b1292	198214.SF1297	1.6e-160	572.0	Gammaproteobacteria													Escherichia	1QUAT@1224,1T1RQ@1236,COG4171@1,COG4171@2	NA|NA|NA	V	peptide transport system, permease
b1293	155864.EDL933_2391	1.4e-178	632.1	Escherichia	sapB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015489,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655,GO:1902047		ko:K19227	ko01503,ko02010,map01503,map02010	M00739			ko00000,ko00001,ko00002,ko02000	3.A.1.5.5			Escherichia	1QUAU@1224,1T1RR@1236,3XM3Z@561,COG4168@1,COG4168@2	NA|NA|NA	V	permease protein sapB
b1294	316407.85674895	0.0	1104.7	Escherichia	sapA	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K19226	ko01503,ko02010,map01503,map02010	M00739			ko00000,ko00001,ko00002,ko02000	3.A.1.5.5			Escherichia	1P91R@1224,1T1RS@1236,3XMBD@561,COG4166@1,COG4166@2	NA|NA|NA	E	to a S.typhimurium protein implicated in antimicrobial peptide resistance, but the SapBCDF operon in E.coli is implicated in putrescine export
b1295	198214.SF1300	1.1e-39	168.7	Gammaproteobacteria													Escherichia	1N182@1224,1SA6U@1236,2CR1B@1,32SN7@2	NA|NA|NA	S	Protein of unknown function (DUF2543)
b1296	316407.85674897	4.7e-260	903.3	Escherichia	puuP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008324,GO:0008519,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015101,GO:0015203,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015489,GO:0015672,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0033554,GO:0034220,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072488,GO:0097164,GO:0098655,GO:0098660,GO:0098662,GO:1901564,GO:1901565,GO:1901575,GO:1902047,GO:1902600		ko:K14052					ko00000,ko02000	2.A.3.1.13		iSBO_1134.SBO_1766	Escherichia	1MXNJ@1224,1RMKV@1236,3XQ7N@561,COG0531@1,COG0531@2	NA|NA|NA	E	putrescine transmembrane transporter activity
b1297	316407.85674898	5.1e-278	963.0	Escherichia	puuA	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0034024,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	6.3.1.11	ko:K09470	ko00330,ko01100,map00330,map01100	M00136	R07414	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_01285,iECBD_1354.ECBD_2320,iECB_1328.ECB_01274,iECD_1391.ECD_01274	Escherichia	1MU6V@1224,1RPNZ@1236,3XQSY@561,COG0174@1,COG0174@2	NA|NA|NA	E	Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine. It is able to use several diamines, spermidine and spermine. Absolutely essential to utilize putrescine as both nitrogen and carbon sources and to decrease the toxicity of putrescine, which can lead to inhibition of cell growth and protein synthesis
b1298	316407.1742119	9.6e-146	522.7	Escherichia	puuD	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0033969,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	3.5.1.94	ko:K09473	ko00330,ko01100,map00330,map01100	M00136	R07419	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000,ko01002				Escherichia	1MV8E@1224,1RS51@1236,3XQRY@561,COG2071@1,COG2071@2	NA|NA|NA	S	Involved in the breakdown of putrescine via hydrolysis of the gamma-glutamyl linkage of gamma-glutamyl-gamma- aminobutyrate
b1299	1440052.EAKF1_ch0119c	9.2e-98	362.8	Gammaproteobacteria													Escherichia	1RCYA@1224,1S4B9@1236,COG1396@1,COG1396@2,COG1917@1,COG1917@2	NA|NA|NA	K	Transcriptional regulator
b1300	316407.1742130	8.6e-284	982.2	Escherichia	puuC	GO:0003674,GO:0003824,GO:0004030,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0055114,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	1.2.1.99	ko:K09472	ko00330,ko01100,map00330,map01100	M00136	R07417,R07418	RC00080	ko00000,ko00001,ko00002,ko01000			iAF1260.b1300,iB21_1397.B21_01288,iBWG_1329.BWG_1132,iECBD_1354.ECBD_2317,iECB_1328.ECB_01277,iECDH10B_1368.ECDH10B_1417,iECDH1ME8569_1439.ECDH1ME8569_1242,iECD_1391.ECD_01277,iECW_1372.ECW_m1396,iEKO11_1354.EKO11_2550,iETEC_1333.ETEC_1404,iEcDH1_1363.EcDH1_2346,iEcHS_1320.EcHS_A1415,iJO1366.b1300,iJR904.b1300,iUMNK88_1353.UMNK88_1636,iWFL_1372.ECW_m1396,iY75_1357.Y75_RS06830	Escherichia	1MU1V@1224,1RMBQ@1236,3XQCS@561,COG1012@1,COG1012@2	NA|NA|NA	C	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid
b1301	316407.1742131	7e-250	869.4	Escherichia	puuB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114		ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_1943	Escherichia	1MVGP@1224,1RNJ9@1236,3XQ8J@561,COG0665@1,COG0665@2	NA|NA|NA	E	putrescine catabolic process
b1302	316407.1742132	1.4e-237	828.6	Escherichia	puuE	GO:0003674,GO:0003824,GO:0003867,GO:0005488,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042402,GO:0043167,GO:0043168,GO:0044106,GO:0044237,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901565,GO:1901575	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007			iSFxv_1172.SFxv_1480,iS_1188.S1389	Escherichia	1MWY6@1224,1RMP0@1236,3XNUA@561,COG0160@1,COG0160@2	NA|NA|NA	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
b1303	316407.1742133	4.3e-183	647.1	Escherichia	pspF	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K03974					ko00000,ko03000				Escherichia	1QV3T@1224,1T278@1236,3XN9C@561,COG1221@1,COG1221@2	NA|NA|NA	K	psp operon transcriptional activator
b1304	155864.EDL933_2378	3.4e-107	394.4	Escherichia	pspA	GO:0003674,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0008289,GO:0009266,GO:0009271,GO:0009408,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009889,GO:0009898,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0031323,GO:0031326,GO:0042802,GO:0043167,GO:0043168,GO:0043207,GO:0043433,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0051704,GO:0051707,GO:0060187,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098562,GO:0098586,GO:1903506,GO:2000112,GO:2001141		ko:K03969					ko00000				Escherichia	1NC7S@1224,1RS0G@1236,3XMFD@561,COG1842@1,COG1842@2	NA|NA|NA	KT	The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspA negatively regulates expression of the pspABCDE promoter and of pspG through negative regulation of the psp-specific transcriptional activator PspF. Is also required for membrane integrity, efficient translocation and maintenance of the proton motive force
b1305	155864.EDL933_2377	7.8e-32	142.5	Escherichia	pspB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03970					ko00000,ko02048				Escherichia	1N769@1224,1SCNV@1236,2CJWQ@1,32YI2@2,3XPZZ@561	NA|NA|NA	S	The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspB is involved in transcription regulation
b1306	155864.EDL933_2376	1.5e-56	225.3	Escherichia	pspC	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0016020,GO:0019222,GO:0044464,GO:0048518,GO:0050789,GO:0060255,GO:0065007,GO:0071944		ko:K03973					ko00000,ko02048,ko03000				Escherichia	1N085@1224,1S98J@1236,3XPT7@561,COG1983@1,COG1983@2	NA|NA|NA	KT	The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspC is involved in transcription regulation
b1307	155864.EDL933_2375	7.7e-32	142.5	Escherichia	pspD	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009271,GO:0009605,GO:0009607,GO:0009615,GO:0016020,GO:0043207,GO:0044464,GO:0050896,GO:0051704,GO:0051707,GO:0071944,GO:0098586		ko:K03971					ko00000				Escherichia	1N8V6@1224,1SDXE@1236,2C1SN@1,32YQQ@2,3XQ0N@561	NA|NA|NA	S	The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions
b1308	316407.1742138	7.3e-52	209.5	Escherichia	pspE	GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0016740,GO:0016782,GO:0016783,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K03972					ko00000			iE2348C_1286.E2348C_1500,iECABU_c1320.ECABU_c15910,iSDY_1059.SDY_1936,ic_1306.c1779	Escherichia	1RHVM@1224,1SD9C@1236,3XPQA@561,COG0607@1,COG0607@2	NA|NA|NA	P	The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspE catalyzes the sulfur- transfer reaction from thiosulfate to cyanide, to form sulfite and thiocyanate. Also able to use dithiol (dithiothreitol) as an alternate sulfur acceptor. Also possesses a very low mercaptopyruvate sulfurtransferase activity
b1309	316407.1742148	0.0	1153.3	Escherichia	ycjM		2.4.1.7	ko:K00690	ko00500,map00500		R00803	RC00028	ko00000,ko00001,ko01000		GH13		Escherichia	1MVKX@1224,1RMXP@1236,3XPEB@561,COG0366@1,COG0366@2	NA|NA|NA	G	Catalyzes the reversible phosphorolysis of glucosylglycerate into alpha-D-glucose 1-phosphate (Glc1P) and D- glycerate. May be a regulator of intracellular levels of glucosylglycerate, a compatible solute that primarily protects organisms facing salt stress and very specific nutritional constraints. Cannot catalyze the phosphorolysis of sucrose
b1310	316407.85674899	3e-240	837.4	Escherichia	ycjN			ko:K02027		M00207			ko00000,ko00002,ko02000	3.A.1.1			Escherichia	1MVHV@1224,1RS5U@1236,3XM39@561,COG1653@1,COG1653@2	NA|NA|NA	G	Bacterial extracellular solute-binding protein
b1311	198214.SF1317	1.8e-159	568.5	Gammaproteobacteria													Escherichia	1MWB7@1224,1RYUP@1236,COG1175@1,COG1175@2	NA|NA|NA	P	transporter
b1312	316407.1742150	5.1e-148	530.4	Escherichia	ycjP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02026		M00207			ko00000,ko00002,ko02000	3.A.1.1			Escherichia	1N4I0@1224,1SYM3@1236,3XNBN@561,COG0395@1,COG0395@2	NA|NA|NA	P	ABC transporter permease protein YcjP
b1313	316407.85674900	2.8e-204	717.6	Escherichia	ycjQ												Escherichia	1QV3S@1224,1RRI1@1236,3XPGB@561,COG1063@1,COG1063@2	NA|NA|NA	E	oxidoreductase activity
b1314	316407.85674901	2.7e-151	541.2	Escherichia	ycjR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MV2C@1224,1RSA5@1236,3XQ5Z@561,COG1082@1,COG1082@2	NA|NA|NA	G	isomerase activity
b1315	316407.1742152	2.8e-204	717.6	Escherichia	ycjS												Escherichia	1NKUI@1224,1RU6K@1236,3XMTS@561,COG0673@1,COG0673@2	NA|NA|NA	S	oxidoreductase activity
b1316	316407.1742153	0.0	1545.8	Escherichia	ycjT	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0016787,GO:0030312,GO:0044464,GO:0071944		ko:K04844					ko00000,ko01000				Escherichia	1MWJE@1224,1RPN6@1236,3XPHE@561,COG1554@1,COG1554@2	NA|NA|NA	G	carbohydrate binding
b1317	316407.1742154	8e-117	426.4	Escherichia	ycjU	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008801,GO:0009292,GO:0009294,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0033554,GO:0042221,GO:0043167,GO:0043169,GO:0044238,GO:0044764,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0071704	5.4.2.6	ko:K01838	ko00500,map00500		R02728,R11310	RC00408	ko00000,ko00001,ko01000				Escherichia	1NDNW@1224,1S1Z7@1236,3XQBP@561,COG0637@1,COG0637@2	NA|NA|NA	S	Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6- (bis)phosphate (beta-G16P) as an intermediate. The beta- phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose
b1318	316407.1742155	5.4e-178	630.2	Escherichia	ycjV			ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606			ko00000,ko00001,ko00002,ko02000	3.A.1.1			Escherichia	1MU3I@1224,1RM9E@1236,3XMFP@561,COG3842@1,COG3842@2	NA|NA|NA	P	ATP-binding protein YcjV
b4524	155864.EDL933_2361	6.3e-14	82.0	Escherichia	ycjV			ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606			ko00000,ko00001,ko00002,ko02000	3.A.1.1			Escherichia	1MU3I@1224,1RM9E@1236,3XMFP@561,COG3842@1,COG3842@2	NA|NA|NA	P	ATP-binding protein YcjV
b1319	316407.85674903	9.5e-185	652.5	Escherichia	ompG	GO:0003674,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0009279,GO:0015144,GO:0015154,GO:0015157,GO:0015267,GO:0015288,GO:0015478,GO:0015481,GO:0015766,GO:0015768,GO:0015772,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0034219,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K14053					ko00000,ko02000	1.B.21.1.1		iECNA114_1301.ECNA114_1509	Escherichia	1R636@1224,1RUMF@1236,28K0Z@1,2Z9QU@2,3XQPG@561	NA|NA|NA	M	Outer membrane protein G
b1320	316407.1742164	5.7e-183	646.7	Escherichia	ycjW	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1R608@1224,1RZY5@1236,3XQAW@561,COG1609@1,COG1609@2	NA|NA|NA	K	Transcriptional regulator
b1321	316407.85674904	7.3e-277	959.1	Escherichia	ycjX			ko:K06918					ko00000				Escherichia	1MX6E@1224,1RQ05@1236,3XMK8@561,COG3106@1,COG3106@2	NA|NA|NA	S	ATP binding
b1322	199310.c1794	2.6e-197	694.5	Escherichia	ycjF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08990					ko00000				Escherichia	1MU8S@1224,1RND9@1236,3XNN9@561,COG3768@1,COG3768@2	NA|NA|NA	S	UPF0283 membrane protein YcjF
b1323	316407.1742168	3.2e-289	1000.3	Escherichia	tyrR	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03721					ko00000,ko03000				Escherichia	1QTS3@1224,1RNAI@1236,3XN47@561,COG3283@1,COG3283@2	NA|NA|NA	K	Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine, tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation, but positive effects on the tyrP gene have been observed at high phenylalanine concentrations
b1324	155864.EDL933_2355	6.7e-87	326.6	Escherichia	tpx	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K11065					ko00000,ko01000				Escherichia	1RAJ9@1224,1S263@1236,3XN62@561,COG2077@1,COG2077@2	NA|NA|NA	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
b1325	316407.1742170	9.2e-178	629.4	Escherichia	ycjG	GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855	5.1.1.20	ko:K19802			R10938	RC03309	ko00000,ko01000			iEC042_1314.EC042_1441,iECUMN_1333.ECUMN_1620	Escherichia	1MW76@1224,1RMKS@1236,3XNFU@561,COG4948@1,COG4948@2	NA|NA|NA	M	Belongs to the mandelate racemase muconate lactonizing enzyme family
b1326	155864.EDL933_2353	5e-144	516.9	Escherichia	mpaA	GO:0000270,GO:0003674,GO:0003824,GO:0004040,GO:0004180,GO:0004181,GO:0005488,GO:0006022,GO:0006026,GO:0006027,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009050,GO:0009056,GO:0009057,GO:0009253,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0030203,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0046872,GO:0046914,GO:0061473,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K14054					ko00000			iEC55989_1330.EC55989_1490,iECO103_1326.ECO103_1491	Escherichia	1N9AY@1224,1RRGU@1236,3XN4D@561,COG2866@1,COG2866@2	NA|NA|NA	E	murein tripeptide carboxypeptidase activity
b4525	316407.85674906	2e-25	120.9	Bacteria													Escherichia	COG0702@1,COG0702@2	NA|NA|NA	GM	epimerase
b1327	316407.85674907	5e-173	613.6	Escherichia	ycjY	GO:0008150,GO:0009987,GO:0051301		ko:K06889					ko00000				Escherichia	1MUCD@1224,1RP4I@1236,3XPND@561,COG1073@1,COG1073@2	NA|NA|NA	S	cell division
b1328	316407.1742185	2e-163	581.6	Escherichia	ycjZ	GO:0001539,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040011,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048870,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051179,GO:0051252,GO:0051253,GO:0051674,GO:0060255,GO:0065007,GO:0071704,GO:0071973,GO:0071978,GO:0080090,GO:0090304,GO:0097159,GO:0097588,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141											Escherichia	1MU2E@1224,1RQ66@1236,3XPH8@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
b1329	316407.85674908	0.0	1094.7	Escherichia	mppA	GO:0005575,GO:0005623,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042886,GO:0042939,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705		ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439			ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25		iUMNK88_1353.UMNK88_1667	Escherichia	1P91R@1224,1RN57@1236,3XN8G@561,COG4166@1,COG4166@2	NA|NA|NA	E	Periplasmic murein peptide-binding protein
b1330	155864.EDL933_2345	2.2e-190	671.4	Escherichia	ynaI	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944		ko:K16052					ko00000,ko02000	1.A.23.4			Escherichia	1MXD2@1224,1RNUB@1236,3XNAZ@561,COG0668@1,COG0668@2	NA|NA|NA	M	Belongs to the MscS (TC 1.A.23) family
b1331	316407.1736552	5.6e-194	683.3	Gammaproteobacteria													Escherichia	1MVDK@1224,1RR0T@1236,COG3039@1,COG3039@2	NA|NA|NA	L	COG3039 Transposase and inactivated derivatives IS5 family
b1332	155864.EDL933_2344	3.5e-36	157.1	Escherichia	ynaJ												Escherichia	1N0ZR@1224,1S9Y9@1236,3XPZ8@561,COG3182@1,COG3182@2	NA|NA|NA	S	Protein of unknown function (DUF2534)
b1333	155864.EDL933_2343	3.2e-183	647.5	Escherichia	uspE	GO:0000302,GO:0001539,GO:0006928,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0033554,GO:0034599,GO:0034614,GO:0034644,GO:0035690,GO:0040011,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044764,GO:0046677,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071478,GO:0071482,GO:0071973,GO:0097237,GO:0097588,GO:0104004,GO:1901700,GO:1901701		ko:K14055					ko00000				Escherichia	1MVZS@1224,1RPAE@1236,3XPAC@561,COG0589@1,COG0589@2	NA|NA|NA	T	Required for resistance to DNA-damaging agents
b1334	155864.EDL933_2342	8.5e-139	499.6	Escherichia	fnr	GO:0000302,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009061,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015980,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042493,GO:0043565,GO:0044212,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0045893,GO:0045935,GO:0048037,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K01420					ko00000,ko03000				Escherichia	1MVGE@1224,1RPTB@1236,3XMYG@561,COG0664@1,COG0664@2	NA|NA|NA	K	Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration
b1335	198214.SF1835	4.7e-96	357.1	Gammaproteobacteria													Escherichia	1N2YQ@1224,1S68H@1236,COG0350@1,COG0350@2	NA|NA|NA	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
b1336	316407.85674910	2.1e-277	961.1	Gammaproteobacteria													Escherichia	1MUJ1@1224,1RMAI@1236,COG2978@1,COG2978@2	NA|NA|NA	H	transporter
b1337	316407.85674911	1.3e-281	974.9	Escherichia	abgB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009109,GO:0009111,GO:0009397,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0019439,GO:0019752,GO:0034641,GO:0042219,GO:0042365,GO:0042558,GO:0042560,GO:0042737,GO:0043436,GO:0043603,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046655,GO:0046657,GO:0046700,GO:0046982,GO:0046983,GO:0051186,GO:0051187,GO:0071704,GO:0071713,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575		ko:K12941					ko00000,ko01002				Escherichia	1MX6N@1224,1RP3N@1236,3XR4V@561,COG1473@1,COG1473@2	NA|NA|NA	S	Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p- aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate. AbgAB does not degrade dipeptides and the physiological role of abgABT should be clarified
b1338	316407.85674912	3e-248	864.0	Escherichia	abgA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009109,GO:0009111,GO:0009397,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0019439,GO:0019752,GO:0034641,GO:0042219,GO:0042365,GO:0042558,GO:0042560,GO:0042737,GO:0043436,GO:0043603,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046655,GO:0046657,GO:0046700,GO:0046982,GO:0046983,GO:0051186,GO:0051187,GO:0071704,GO:0071713,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575		ko:K12940					ko00000,ko01002				Escherichia	1MUIV@1224,1RRJI@1236,3XRJ1@561,COG1473@1,COG1473@2	NA|NA|NA	E	Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p- aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate. AbgAB does not degrade dipeptides and the physiological role of abgABT should be clarified
b1339	316407.1742206	7.3e-169	599.7	Escherichia	abgR			ko:K14057					ko00000,ko03000				Escherichia	1P2I1@1224,1RN0V@1236,3XRJC@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
b1340	316407.85674913	7.9e-105	386.3	Escherichia	ydaL	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363											Escherichia	1RH34@1224,1S6B5@1236,3XMKT@561,COG2840@1,COG2840@2	NA|NA|NA	L	endodeoxyribonuclease activity
b1341	316407.85674914	2.2e-237	827.8	Escherichia	ydaM	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016740,GO:0016772,GO:0016779,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043900,GO:0043902,GO:0044093,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051090,GO:0051091,GO:0051171,GO:0051252,GO:0052621,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:1900190,GO:1900192,GO:1900231,GO:1900233,GO:1903506,GO:2000112,GO:2001141	2.7.7.65	ko:K21088	ko02026,map02026				ko00000,ko00001,ko01000				Escherichia	1NAG0@1224,1RPKX@1236,3XN91@561,COG2199@1,COG3706@2	NA|NA|NA	T	Part of a 2 protein system that seems to be dedicated to regulate transcription of csgD. The CsdG protein in turn regulates expression of adhesive curli fimbriae genes csgEFG, csgBAC ymaD and adrA (yaic). Activity of this protein is antagonized by the phosphodiesterase Gmr (YciR). In vitro has weak diguanylate cyclase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
b1342	155864.EDL933_2331	1e-187	662.5	Escherichia	zntB	GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662		ko:K16074					ko00000,ko02000	1.A.35.4			Escherichia	1MW8W@1224,1RRTZ@1236,3XN7N@561,COG0598@1,COG0598@2	NA|NA|NA	P	Mediates efflux of zinc ions
b1343	316407.1742212	7.5e-258	896.0	Escherichia	dbpA	GO:0000027,GO:0000166,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008144,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033677,GO:0034458,GO:0034459,GO:0034622,GO:0034641,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901363	3.6.4.13	ko:K05591					ko00000,ko01000,ko03009				Escherichia	1MU49@1224,1RQ36@1236,3XNIY@561,COG0513@1,COG0513@2	NA|NA|NA	F	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes
b1344	316407.85674916	8.6e-181	639.4	Escherichia	ttcA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360		ko:K14058					ko00000,ko03016				Escherichia	1MW5Q@1224,1RN2H@1236,3XP9A@561,COG0037@1,COG0037@2	NA|NA|NA	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system
b1345	316407.85674917	5.7e-241	839.7	Escherichia	intR			ko:K14059					ko00000				Escherichia	1MVZB@1224,1RP4Y@1236,3XM9F@561,COG0582@1,COG0582@2	NA|NA|NA	L	Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome (By similarity)
b1346	155864.EDL933_2327	1.3e-36	158.3	Escherichia	ydaQ	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0008150,GO:0016032,GO:0019042,GO:0019045,GO:0019046,GO:0032359,GO:0043565,GO:0044403,GO:0044419,GO:0051704,GO:0097159,GO:1901363,GO:1990837											Escherichia	1NC4W@1224,1SF39@1236,2E46E@1,32Z2C@2,3XR3N@561	NA|NA|NA	S	Putative excisionase (DUF1233)
b1347	316407.1742213	2.4e-30	137.5	Gammaproteobacteria													Escherichia	1P1BF@1224,1SSR7@1236,2FGCN@1,3488V@2	NA|NA|NA	J	response to antibiotic
b1348	316407.1742214	3e-32	143.7	Gammaproteobacteria													Escherichia	1P1C7@1224,1SSFP@1236,2FHJY@1,349DV@2	NA|NA|NA	L	Toxic component of a type I toxin-antitoxin (TA) system. Upon overexpression inhibits growth and reduces colony-forming units in both the presence and absence of the Rac prophage, cells become filamentous. Has deoxyribonuclease activity (probably endonucleolytic), does not digest RNA. Its toxic effects are neutralized by sRNA antitoxin RalA, which is encoded in trans on the opposite DNA strand. Has RAL-like activity
b1349	316407.1742215	4.9e-148	530.4	Escherichia	recT	GO:0000724,GO:0000725,GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0018130,GO:0019438,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043150,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K07455					ko00000,ko03400				Escherichia	1R6DB@1224,1RZZ3@1236,3XN6G@561,COG3723@1,COG3723@2	NA|NA|NA	L	Binds to single-stranded DNA and also promotes the renaturation of complementary single-stranded DNA. Function in recombination. Has a function
b1350	316407.85674919	0.0	1761.1	Escherichia	recE	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005515,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008309,GO:0008409,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0034641,GO:0035312,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051908,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360		ko:K10906					ko00000,ko01000,ko03400				Escherichia	1QWC0@1224,1T2TC@1236,3XPTI@561,COG0847@1,COG0847@2	NA|NA|NA	L	Is involved in the RecE pathway of recombination. Catalyzes the degradation of double-stranded DNA. Acts progressively in a 5' to 3' direction, releasing 5'- phosphomononucleotides. Has a strong preference for linear duplex substrate DNA and appears to be unable to initiate degradation from single-stranded breaks in DNA
b1351	316407.1742220	8.4e-44	182.6	Escherichia													Escherichia	1RKJN@1224,1S6PX@1236,2C72K@1,32RI9@2,3XR0H@561	NA|NA|NA		
b4526	155864.EDL933_2321	2.4e-25	120.6	Gammaproteobacteria													Escherichia	1PAM6@1224,1SV9M@1236,2DFM4@1,2ZS9G@2	NA|NA|NA	S	zinc ion binding
b1352	316407.1742222	5.2e-36	156.4	Gammaproteobacteria													Escherichia	1N15W@1224,1SC5P@1236,2D91W@1,32TSE@2	NA|NA|NA	S	Causes inhibition of cell division. At high levels of expression, can also abolish the rod shape of the cells. Division inhibition by KilR can be relieved by overexpression of the cell division protein FtsZ
b4527	155864.EDL933_2318	6.6e-22	109.0	Escherichia													Escherichia	1QIQB@1224,1TGJN@1236,2E72D@1,31KUZ@2,3XR7K@561	NA|NA|NA	S	Protein of unknown function (DUF1391)
b1355	155864.EDL933_2317	2.2e-18	97.1	Escherichia													Escherichia	1QIS1@1224,1TGME@1236,2AWTG@1,31NQI@2,3XRB0@561	NA|NA|NA	S	UBA-like domain
b1356	316407.85674921	5.9e-85	320.1	Gammaproteobacteria													Escherichia	1MYRR@1224,1S7DV@1236,2DM5G@1,31T0C@2	NA|NA|NA	K	nucleic acid-templated transcription
b1357	316407.85674922	2.9e-50	204.1	Gammaproteobacteria													Escherichia	1NF6D@1224,1SDR1@1236,COG4197@1,COG4197@2	NA|NA|NA	S	sequence-specific DNA binding
b1358	316407.85674923	4.6e-73	280.4	Escherichia	ydaT												Escherichia	1RA5R@1224,1S3DW@1236,2BPMT@1,2ZNFG@2,3XQKV@561	NA|NA|NA	S	Putative bacterial toxin ydaT
b1359	316407.85674924	1.8e-137	495.4	Escherichia	ydaU												Escherichia	1R5PT@1224,1S00W@1236,3XQ4Y@561,COG3756@1,COG3756@2	NA|NA|NA	S	Protein involved in DNA replication initiation, regulation of DNA replication, viral process and DNA replication
b1360	316407.1742225	2.5e-138	498.0	Escherichia	ydaV	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0022616,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576		ko:K10762					ko00000				Escherichia	1R4QQ@1224,1RYGZ@1236,3XM2M@561,COG1484@1,COG1484@2	NA|NA|NA	A	DNA strand elongation
b1361	316407.85674925	1e-96	359.4	Bacteria													Escherichia	COG1846@1,COG1846@2	NA|NA|NA	K	DNA-binding transcription factor activity
b1362	469008.B21_01348	2.2e-45	188.0	Escherichia				ko:K14744					ko00000,ko01000				Escherichia	1N10F@1224,1S95X@1236,2DP4N@1,330HV@2,3XPIW@561	NA|NA|NA	S	Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the murein component of the bacterial cell wall (By similarity)
b4528	10710.SPAN2_LAMBD	2.1e-14	84.3	Siphoviridae													Escherichia	4QF9F@10239,4QMD5@10699,4QQYT@28883,4QW74@35237	NA|NA|NA	S	Lipoprotein Rz1 precursor
b1363	316407.1742227	1.6e-274	951.4	Escherichia	trkG	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K03498					ko00000,ko02000	2.A.38.1,2.A.38.4		iECDH1ME8569_1439.ECDH1ME8569_1308	Escherichia	1MUIJ@1224,1RQNY@1236,3XNK1@561,COG0168@1,COG0168@2	NA|NA|NA	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA
b1365	316407.85674928	2.9e-41	174.1	Escherichia	ynaK												Escherichia	1PCSS@1224,1TKI7@1236,3XR45@561,COG1475@1,COG1475@2	NA|NA|NA	K	ParB-like nuclease domain
b1366	316407.85674929	1.6e-58	231.9	Escherichia													Escherichia	1RCZC@1224,1S5R3@1236,2DKUB@1,30C1N@2,3XQZQ@561	NA|NA|NA		
b1368	316407.1742228	2e-170	605.1	Escherichia													Escherichia	1MU81@1224,1RS6P@1236,3XQ8T@561,COG1196@1,COG1196@2	NA|NA|NA	D	Prophage tail length tape measure protein
b4570	1440052.EAKF1_ch1857c	3.9e-33	146.7	Gammaproteobacteria													Escherichia	1RH8M@1224,1SE1S@1236,COG3637@1,COG3637@2	NA|NA|NA	M	Corresponds to locus_tag
b1370	316407.85674930	2.1e-185	654.8	Gammaproteobacteria													Escherichia	1MVDK@1224,1RR0T@1236,COG3039@1,COG3039@2	NA|NA|NA	L	COG3039 Transposase and inactivated derivatives IS5 family
b1372	316407.1742233	0.0	1198.3	Escherichia	stfR												Escherichia	1RFCQ@1224,1S5SP@1236,3XQHT@561,COG5301@1,COG5301@2	NA|NA|NA	M	tail fiber protein
b1373	316407.1742246	5e-107	393.7	Escherichia	tfaR												Escherichia	1MYT5@1224,1S7KD@1236,3XPJT@561,COG2110@1,COG2110@2	NA|NA|NA	S	Tail fiber assembly protein homolog from lambdoid prophage
b1374	199310.c3146	1.6e-103	382.1	Escherichia	pinR	GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360		ko:K14060					ko00000				Escherichia	1RA0V@1224,1RPSK@1236,3XR8X@561,COG1961@1,COG1961@2	NA|NA|NA	L	recombinase activity
b1375	316407.85674931	7.1e-36	156.0	Gammaproteobacteria													Escherichia	1N9CF@1224,1SFBX@1236,2E5B9@1,3303D@2	NA|NA|NA	K	response to cold
b1376	316407.1742248	5.2e-72	276.9	Escherichia	uspF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0006950,GO:0006979,GO:0007155,GO:0008144,GO:0008150,GO:0017076,GO:0022610,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K14061					ko00000				Escherichia	1NQCZ@1224,1SZ47@1236,3XPMZ@561,COG0589@1,COG0589@2	NA|NA|NA	T	cell adhesion
b1377	316407.1742249	2.1e-218	764.6	Escherichia	ompN	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0009279,GO:0015267,GO:0015288,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K14062					ko00000,ko02000	1.B.1.1		iECO26_1355.ECO26_1980,iZ_1308.Z2333	Escherichia	1MVRY@1224,1RNBS@1236,3XN4M@561,COG3203@1,COG3203@2	NA|NA|NA	M	Outer membrane protein N
b1378	316407.1742250	0.0	2348.9	Escherichia	ydbK	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0016625,GO:0016903,GO:0043873,GO:0050896,GO:0055114	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000			iLF82_1304.LF82_2789,iNRG857_1313.NRG857_06920	Escherichia	1MVM0@1224,1RNNX@1236,3XMK9@561,COG0674@1,COG0674@2,COG1013@1,COG1013@2,COG1014@1,COG1014@2,COG1143@1,COG1143@2	NA|NA|NA	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
b4529	316407.85674932	3.2e-40	170.6	Escherichia	ydbJ												Escherichia	1RIV0@1224,1S71D@1236,3XPUC@561,COG3042@1,COG3042@2	NA|NA|NA	S	Domain of unknown function (DUF333)
b1379	316407.1742252	7.3e-71	273.1	Escherichia	hslJ	GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896		ko:K03668					ko00000				Escherichia	1RFSD@1224,1S6MZ@1236,3XPKD@561,COG3187@1,COG3187@2	NA|NA|NA	O	Heat shock protein HslJ
b1380	316407.1742259	3.6e-185	654.1	Escherichia	ldhA	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006067,GO:0006082,GO:0006083,GO:0006089,GO:0006090,GO:0006091,GO:0006103,GO:0006105,GO:0006113,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008720,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015942,GO:0015980,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019318,GO:0019362,GO:0019637,GO:0019660,GO:0019664,GO:0019666,GO:0019693,GO:0019752,GO:0032787,GO:0034308,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0050896,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0070404,GO:0071704,GO:0072521,GO:0072524,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901615	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120		R00704	RC00044	ko00000,ko00001,ko01000			iSFV_1184.SFV_1805,iSF_1195.SF1814,iSFxv_1172.SFxv_2031,iS_1188.S1459	Escherichia	1MVSS@1224,1RMWR@1236,3XMY4@561,COG1052@1,COG1052@2	NA|NA|NA	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
b1381	316407.1742260	0.0	1747.6	Escherichia	ydbH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MUT7@1224,1RQ5W@1236,3XMNC@561,COG2911@1,COG2911@2	NA|NA|NA	S	Dicarboxylate transport
b1382	198214.SF1816	5e-24	116.3	Gammaproteobacteria													Escherichia	1N8D8@1224,1SCAF@1236,2E371@1,32Y6T@2	NA|NA|NA	S	(Lipo)protein
b1383	316407.85674934	1e-51	209.1	Escherichia	ydbL			ko:K09978					ko00000				Escherichia	1N6R1@1224,1SC8V@1236,3XQ16@561,COG3784@1,COG3784@2	NA|NA|NA	S	Protein of unknown function (DUF1318)
b1384	316407.85674935	5.4e-172	610.1	Gammaproteobacteria													Escherichia	1QUXX@1224,1RSPT@1236,COG2207@1,COG2207@2	NA|NA|NA	K	transcriptional regulator
b1385	316407.85674936	1.6e-290	1004.6	Gammaproteobacteria													Escherichia	1MU1V@1224,1RMBQ@1236,COG1012@1,COG1012@2	NA|NA|NA	C	belongs to the aldehyde dehydrogenase family
b1386	316407.1742266	0.0	1566.2	Gammaproteobacteria													Escherichia	1MW7W@1224,1RNPU@1236,COG3733@1,COG3733@2	NA|NA|NA	Q	amine oxidase
b1387	316407.1742267	0.0	1342.4	Gammaproteobacteria													Escherichia	1MWD4@1224,1RVX0@1236,COG1012@1,COG1012@2,COG2030@1,COG2030@2	NA|NA|NA	CI	Aldehyde dehydrogenase
b1388	316407.85674937	2.2e-181	641.3	Gammaproteobacteria													Escherichia	1MVQ7@1224,1RNRN@1236,COG3396@1,COG3396@2	NA|NA|NA	S	Phenylacetate-CoA oxygenase
b1389	316407.85674938	1.1e-49	202.2	Gammaproteobacteria													Escherichia	1RHM5@1224,1S7F4@1236,COG3460@1,COG3460@2	NA|NA|NA	Q	Phenylacetate-CoA oxygenase
b1390	316407.85674939	4.1e-141	507.3	Gammaproteobacteria													Escherichia	1MVYQ@1224,1RRSG@1236,COG3396@1,COG3396@2	NA|NA|NA	S	Phenylacetate-CoA oxygenase, PaaI subunit
b1391	316407.85674940	1.7e-95	355.1	Gammaproteobacteria													Escherichia	1RF3S@1224,1S4FY@1236,COG2151@1,COG2151@2	NA|NA|NA	L	phenylacetate-CoA oxygenase, PaaJ subunit
b1392	316407.85674941	1.7e-201	708.4	Gammaproteobacteria													Escherichia	1MY2Q@1224,1RQZ8@1236,COG1018@1,COG1018@2	NA|NA|NA	C	COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1
b1393	316407.85674942	2.5e-130	471.5	Gammaproteobacteria													Escherichia	1MWZC@1224,1RPSX@1236,COG1024@1,COG1024@2	NA|NA|NA	I	Belongs to the enoyl-CoA hydratase isomerase family
b1394	316407.1742270	9.9e-146	522.7	Gammaproteobacteria													Escherichia	1MVQN@1224,1RPE2@1236,COG1024@1,COG1024@2	NA|NA|NA	I	Enoyl-CoA hydratase
b1395	316407.85674943	2.3e-265	921.0	Escherichia	paaH	GO:0003674,GO:0003824,GO:0003857,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0008691,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120		R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000			iECO103_1326.ECO103_1532	Escherichia	1MU9P@1224,1RPVB@1236,3XRJK@561,COG1250@1,COG1250@2	NA|NA|NA	I	3-hydroxyacyl-CoA dehydrogenase
b1396	316407.85674944	7e-74	283.1	Gammaproteobacteria													Escherichia	1RH35@1224,1S4EZ@1236,COG2050@1,COG2050@2	NA|NA|NA	Q	phenylacetic acid degradation protein
b1397	316407.1742272	2.4e-220	771.2	Escherichia	paaJ	GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0006805,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016740,GO:0016746,GO:0016747,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0033554,GO:0033812,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	2.3.1.174,2.3.1.223	ko:K02615	ko00360,ko01120,map00360,map01120		R00829,R09839	RC00004,RC00326,RC03003	ko00000,ko00001,ko01000				Escherichia	1MU5G@1224,1RM93@1236,3XM40@561,COG0183@1,COG0183@2	NA|NA|NA	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed
b1398	316407.85674945	4.6e-257	893.3	Gammaproteobacteria													Escherichia	1MV1W@1224,1RQ3D@1236,COG1541@1,COG1541@2	NA|NA|NA	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
b1399	316407.85674946	1.8e-178	631.7	Gammaproteobacteria													Escherichia	1R4IF@1224,1RR7B@1236,COG3327@1,COG3327@2	NA|NA|NA	K	phenylacetic acid degradation operon negative regulatory protein
b1400	316407.1742279	2.7e-79	301.6	Gammaproteobacteria													Escherichia	1MVUI@1224,1RYPQ@1236,COG0663@1,COG0663@2	NA|NA|NA	S	Phenylacetic acid degradation protein PaaY
b4492	362663.ECP_1410	5e-90	339.3	Gammaproteobacteria													Escherichia	1Q9S2@1224,1RSN7@1236,COG3468@1,COG3468@2,COG4625@1,COG4625@2	NA|NA|NA	U	domain, Protein
b1402	316407.2447044	3.9e-178	630.6	Gammaproteobacteria													Escherichia	1MY62@1224,1RQSR@1236,COG2801@1,COG2801@2	NA|NA|NA	L	cog cog2801
b1403	1440052.EAKF1_ch0283	7.2e-59	233.0	Escherichia													Escherichia	1N0V0@1224,1S7WV@1236,3XRHH@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
b1404	316407.1742285	3.7e-218	763.8	Escherichia	insI3	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363											Escherichia	1PP49@1224,1RN7B@1236,3XQB0@561,COG2826@1,COG2826@2	NA|NA|NA	L	Transposase insI for insertion sequence element
b1406	316407.1742295	6.5e-159	566.6	Escherichia	ydbC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120		R01708	RC00116	ko00000,ko00001,ko01000				Escherichia	1MWGZ@1224,1RRHM@1236,3XN0D@561,COG0667@1,COG0667@2	NA|NA|NA	C	Catalyzes the NAD(P)H-dependent reduction of pyridoxal to pyridoxine in vitro. Is not able to reduce 4-pyridoxate, and to oxidize pyridoxine or pyridoxamine. Has Kemp eliminase activity towards the non-physiological substrate 5- nitrobenzisoxazole, producing 4-nitro-2-cyanophenol
b1407	316407.85674947	0.0	1477.6	Escherichia	ydbD												Escherichia	1NS8J@1224,1SMS5@1236,2EWBD@1,33PQ4@2,3XQG9@561	NA|NA|NA	S	Protein of unknown function (DUF2773)
b1408	316407.85674948	9.4e-104	382.9	Escherichia	ynbA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RE0I@1224,1S2UQ@1236,3XR1R@561,COG0558@1,COG0558@2	NA|NA|NA	I	phosphotransferase activity, for other substituted phosphate groups
b1409	316407.85674949	1.2e-163	582.4	Escherichia	ynbB	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009273,GO:0009987,GO:0016020,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071840,GO:0071944	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000				Escherichia	1MX58@1224,1RRAG@1236,3XQ6J@561,COG4589@1,COG4589@2	NA|NA|NA	S	peptidoglycan-based cell wall biogenesis
b1410	316407.85674950	0.0	1185.2	Escherichia	ynbC	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0071704											Escherichia	1MWF5@1224,1RNQR@1236,3XQTU@561,COG2267@1,COG2267@2	NA|NA|NA	I	lipase activity
b1411	316407.85674951	1.3e-259	901.7	Escherichia	ynbD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1QSUD@1224,1RQAC@1236,3XQE9@561,COG0671@1,COG0671@2,COG2453@1,COG2453@2	NA|NA|NA	IT	protein tyrosine phosphatase activity
b1412	316407.1742298	1.3e-105	389.0	Escherichia	azoR	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0010181,GO:0016491,GO:0016651,GO:0016655,GO:0016661,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0046857,GO:0048037,GO:0050446,GO:0050662,GO:0050896,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K01118					ko00000,ko01000				Escherichia	1P59R@1224,1S337@1236,3XN1B@561,COG1182@1,COG1182@2	NA|NA|NA	I	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
b1413	511145.b1413	0.0	2594.7	Escherichia	hrpA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K03578					ko00000,ko01000				Escherichia	1MUEQ@1224,1RMU1@1236,3XN59@561,COG1643@1,COG1643@2	NA|NA|NA	L	helicase HrpA
b1414	316407.1742305	1.4e-155	555.4	Escherichia	ydcF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944											Escherichia	1N4TG@1224,1RSJ5@1236,3XP6S@561,COG1434@1,COG1434@2	NA|NA|NA	S	DUF218 domain
b1415	316407.1742307	2.5e-272	944.1	Escherichia	aldA	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004029,GO:0004777,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006004,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006807,GO:0008150,GO:0008152,GO:0008911,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009448,GO:0009450,GO:0009987,GO:0016043,GO:0016052,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019299,GO:0019301,GO:0019317,GO:0019318,GO:0019320,GO:0019752,GO:0022607,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0042354,GO:0042355,GO:0042802,GO:0043436,GO:0043648,GO:0043649,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0048037,GO:0050569,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051287,GO:0051289,GO:0055114,GO:0065003,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.21,1.2.1.22	ko:K07248	ko00620,ko00630,ko01120,map00620,map00630,map01120		R00203,R01333,R01446	RC00080,RC00104,RC00242	ko00000,ko00001,ko01000			iAF1260.b1415,iBWG_1329.BWG_1242,iECDH10B_1368.ECDH10B_1541,iECDH1ME8569_1439.ECDH1ME8569_1358,iEcDH1_1363.EcDH1_2230,iJO1366.b1415,iJR904.b1415,iY75_1357.Y75_RS07435	Escherichia	1MU1V@1224,1RMBQ@1236,3XMD7@561,COG1012@1,COG1012@2	NA|NA|NA	C	dehydrogenase
b4493	469008.B21_01383	3.7e-134	484.6	Escherichia	gapC	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147			iJR904.b1416,iJR904.b1417	Escherichia	1MU93@1224,1RMBM@1236,3XQM0@561,COG0057@1,COG0057@2	NA|NA|NA	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
b1418	155864.EDL933_2231	5.7e-97	360.1	Escherichia	cybB	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0020037,GO:0044464,GO:0046906,GO:0048037,GO:0071944,GO:0097159,GO:1901363		ko:K12262					ko00000				Escherichia	1MWQJ@1224,1S4DB@1236,3XMPH@561,COG3038@1,COG3038@2	NA|NA|NA	C	Cytochrome b(561)
b1419	198214.SF1793	2.1e-24	117.5	Gammaproteobacteria													Escherichia	1NKD8@1224,1SGNH@1236,2DSX4@1,33HSK@2	NA|NA|NA		
b4428	316407.85674953	1.2e-09	68.2	Bacteria													Escherichia	2EFY7@1,339QC@2	NA|NA|NA	S	Hok/gef family
b1421	316407.1742320	3.2e-215	754.6	Escherichia	trg	GO:0003674,GO:0004888,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0009605,GO:0009987,GO:0016020,GO:0016021,GO:0023052,GO:0031224,GO:0031226,GO:0032991,GO:0038023,GO:0040011,GO:0042221,GO:0042330,GO:0042802,GO:0042803,GO:0044425,GO:0044459,GO:0044464,GO:0046983,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071944,GO:0098561		ko:K05876	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Escherichia	1MU9B@1224,1RMH0@1236,3XMAQ@561,COG0840@1,COG0840@2	NA|NA|NA	NT	Mediates taxis to the sugars ribose and galactose via an interaction with the periplasmic ribose- or galactose-binding proteins
b1422	316407.85674955	4.7e-171	607.1	Escherichia	ydcI	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141											Escherichia	1MX53@1224,1RS04@1236,3XPDJ@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
b1423	316407.85674956	1.6e-257	894.8	Escherichia	ydcJ												Escherichia	1P16G@1224,1RR9P@1236,3XNHY@561,COG5383@1,COG5383@2	NA|NA|NA	S	DUF1338
b1424	469008.B21_01393	0.0	1159.8	Escherichia	mdoD	GO:0005575,GO:0005623,GO:0006109,GO:0008150,GO:0009889,GO:0010556,GO:0010675,GO:0010962,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031326,GO:0031975,GO:0032881,GO:0032885,GO:0032950,GO:0032951,GO:0042597,GO:0043255,GO:0044464,GO:0050789,GO:0050794,GO:0060255,GO:0065007,GO:0080090,GO:2000112											Escherichia	1MUNX@1224,1RMEB@1236,3XNJA@561,COG3131@1,COG3131@2	NA|NA|NA	P	Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs)
b1426	316407.85674957	1.6e-32	144.8	Escherichia	ydcH			ko:K09794					ko00000				Escherichia	1N760@1224,1SD65@1236,3XQ4I@561,COG2841@1,COG2841@2	NA|NA|NA	S	Protein of unknown function (DUF465)
b1427	316407.1742324	6.2e-99	366.7	Escherichia	rimL	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017198,GO:0018193,GO:0018209,GO:0019538,GO:0030920,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1990189		ko:K03817					ko00000,ko01000,ko03009				Escherichia	1RGKF@1224,1S28M@1236,3XMIJ@561,COG1670@1,COG1670@2	NA|NA|NA	J	N-terminal peptidyl-serine acetylation
b1428	316407.85674958	8.9e-112	410.2	Escherichia	ydcK												Escherichia	1QWBX@1224,1T2TA@1236,3XM3M@561,COG0663@1,COG0663@2	NA|NA|NA	S	transferase activity, transferring acyl groups
b1429	316407.1742336	1.3e-182	645.6	Escherichia	tehA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0010035,GO:0015075,GO:0015562,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042802,GO:0044464,GO:0046583,GO:0046690,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655		ko:K03304					ko00000,ko02000	2.A.16.1			Escherichia	1MVPG@1224,1RPVM@1236,3XNVK@561,COG1275@1,COG1275@2	NA|NA|NA	P	Tellurite resistance protein tehA
b1430	316407.1742337	1.1e-109	402.5	Escherichia	tehB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0010035,GO:0016740,GO:0016741,GO:0032259,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046690,GO:0050896	2.1.1.265	ko:K16868					ko00000,ko01000				Escherichia	1MX7K@1224,1RSD0@1236,3XNT6@561,COG0500@1,COG0500@2	NA|NA|NA	Q	Tellurite resistance
b1431	155864.EDL933_2219	3.8e-122	444.1	Escherichia	ydcL												Escherichia	1PZJF@1224,1S1AH@1236,28IHQ@1,2Z8IX@2,3XM9V@561	NA|NA|NA	M	Protein of unknown function (DUF3313)
b1432	316407.85674960	3.4e-211	740.7	Escherichia	insQ			ko:K07496					ko00000				Escherichia	1MUU0@1224,1RS1J@1236,3XPN5@561,COG0675@1,COG0675@2	NA|NA|NA	L	Transposase
b1433	316407.85674961	1.1e-204	719.2	Escherichia	ydcO	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K05782					ko00000,ko02000	2.A.46.1			Escherichia	1MUS1@1224,1RMD5@1236,3XNV8@561,COG3135@1,COG3135@2	NA|NA|NA	Q	benzoate transport
b1434	316407.1742340	5.2e-98	363.6	Escherichia	ydcN	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141											Escherichia	1R4NU@1224,1RQG0@1236,3XPJ9@561,COG1396@1,COG1396@2	NA|NA|NA	K	Regulates the expression of 12-16 transcription units involved in various steps of sulfur utilization. Represses expression of pfkB, fliZ, cysE, ydcO and its own expression. Activates expression of ypfN. Acts by binding to SutR boxes
b1435	155864.EDL933_2216	0.0	1317.8	Escherichia	ydcP			ko:K08303	ko05120,map05120				ko00000,ko00001,ko01000,ko01002				Escherichia	1MUQG@1224,1RN7S@1236,3XN5V@561,COG0826@1,COG0826@2	NA|NA|NA	O	peptidase activity
b1436	316407.85674962	1.2e-35	155.2	Escherichia	yncJ												Escherichia	1N3QK@1224,1SC16@1236,2DTBF@1,32UUW@2,3XQ27@561	NA|NA|NA	S	Protein of unknown function (DUF2554)
b4532	155864.EDL933_2213	6.6e-26	122.5	Escherichia	hicA	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K07339					ko00000,ko01000,ko02048				Escherichia	1NAEE@1224,1SCFQ@1236,3XRBG@561,COG1724@1,COG1724@2	NA|NA|NA	J	this blockage is overcome (after 90 minutes) by subsequent expression of antitoxin HicB. Overexpression causes cleavage of a number of mRNAs and tmRNA, in a translation-independent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics
b1438	155864.EDL933_2212	6.7e-69	266.5	Escherichia	hicB			ko:K18843					ko00000,ko02048				Escherichia	1RI8S@1224,1S7DJ@1236,3XPY0@561,COG1598@1,COG1598@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin
b1439	316407.1742348	7.4e-269	932.6	Escherichia	ydcR	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1MV6F@1224,1RMQ0@1236,3XMGP@561,COG1167@1,COG1167@2	NA|NA|NA	K	Transcriptional regulator
b1440	316407.85674965	3.8e-231	807.0	Escherichia	ydcS	GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008152,GO:0009058,GO:0009290,GO:0009292,GO:0009294,GO:0009987,GO:0015931,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042618,GO:0042619,GO:0044464,GO:0044764,GO:0050657,GO:0051027,GO:0051179,GO:0051234,GO:0051704,GO:0071702,GO:0071704,GO:0071705,GO:0098657,GO:1901440,GO:1901441,GO:1901576		ko:K02055	ko02024,map02024	M00193			ko00000,ko00001,ko00002,ko02000	3.A.1.11		iECNA114_1301.ECNA114_1576,iECSF_1327.ECSF_1364,iEcHS_1320.EcHS_A1524	Escherichia	1NKD7@1224,1RQPF@1236,3XMXD@561,COG0687@1,COG0687@2	NA|NA|NA	P	ABC transporter
b1441	316407.1742349	1.1e-189	669.1	Escherichia	ydcT			ko:K02052	ko02024,map02024	M00193			ko00000,ko00001,ko00002,ko02000	3.A.1.11			Escherichia	1MU3I@1224,1RNPX@1236,3XNK0@561,COG3842@1,COG3842@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
b1442	316407.1742350	1.3e-171	609.0	Escherichia	ydcU	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02054	ko02024,map02024	M00193			ko00000,ko00001,ko00002,ko02000	3.A.1.11		iEcSMS35_1347.EcSMS35_1732	Escherichia	1NU6V@1224,1RZ7V@1236,3XN29@561,COG1176@1,COG1176@2	NA|NA|NA	P	ABC transporter permease
b1443	198214.SF1775	3.9e-142	510.8	Gammaproteobacteria													Escherichia	1N3TB@1224,1RP67@1236,COG1177@1,COG1177@2	NA|NA|NA	P	ABC transporter (permease)
b1444	316407.1742352	7e-275	952.6	Escherichia	prr	GO:0003674,GO:0003824,GO:0004029,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0019145,GO:0033737,GO:0034641,GO:0042402,GO:0042802,GO:0044106,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575	1.2.1.19	ko:K00137	ko00330,ko00410,ko01100,map00330,map00410,map01100		R02549	RC00080	ko00000,ko00001,ko01000			iAF1260.b1444,iBWG_1329.BWG_1269,iECDH10B_1368.ECDH10B_1574,iECDH1ME8569_1439.ECDH1ME8569_1387,iEcDH1_1363.EcDH1_2202,iJO1366.b1444,iY75_1357.Y75_RS07595	Escherichia	1MU1V@1224,1RMBQ@1236,3XN8Z@561,COG1012@1,COG1012@2	NA|NA|NA	C	Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4- aminobutanoate (GABA)
b1445	199310.c1870	1.1e-22	111.7	Escherichia	ydcX												Escherichia	1N8R7@1224,1SCPI@1236,2E4I9@1,32ZDC@2,3XQ4N@561	NA|NA|NA	S	Toxin GhoT_OrtT
b1446	155864.EDL933_2203	1.5e-33	148.3	Escherichia	ydcY	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N4XF@1224,1S8R1@1236,2D0NU@1,32T8Y@2,3XQ20@561	NA|NA|NA	S	Protein of unknown function (DUF2526)
b1447	316407.85674968	1.2e-71	275.8	Escherichia	ydcZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K09936	ko02024,map02024				ko00000,ko00001,ko02000	2.A.7.21			Escherichia	1RACX@1224,1S218@1236,3XPJM@561,COG3238@1,COG3238@2	NA|NA|NA	S	Putative inner membrane exporter, YdcZ
b1448	316407.85674969	1.6e-96	358.6	Escherichia	yncA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130		R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000				Escherichia	1RDNE@1224,1RR6A@1236,3XNM3@561,COG1247@1,COG1247@2	NA|NA|NA	M	Acyltransferase that appears to be required for E.coli optimal growth rate and yield via the formation of N-acetylated amino acids. Catalyzes the acylation of L-methionine using acetyl- CoA or propanoyl-CoA as acyl donors, and the acetylation of L- phenylglycine. Is also able to N-acylate other free L-amino acids and their derivatives using a CoA thioester as cosubstrate. Using acetyl-CoA as an acyl donor, substrate specificity is methionine sulfone methionine sulfoximine methionine sulfoxide methionine. Asparagine, lysine, glutamine, aspartate and glutamate are very poor substrates. Using methionine as a substrate, acyl donor preference is propanoyl-CoA acetyl- CoA butyryl-CoA (Ref.4). Likely plays a role in the resistance against the toxic effects of L-methionine sulfoximine (MSX), via its ability to catalyze its acetylation
b1449	155864.EDL933_2200	4.7e-204	716.8	Escherichia	yncB			ko:K07119					ko00000				Escherichia	1MUC2@1224,1RNGM@1236,3XNV4@561,COG2130@1,COG2130@2	NA|NA|NA	S	Catalyzes the metal-independent reduction of curcumin to dihydrocurcumin (DHC) as an intermediate product, followed by further reduction to tetrahydrocurcumin (THC) as an end product. It also acts on 3-octene-2-one, 3-hepten-2-one, resveratrol, and trans-2-octenal
b1450	316407.1742362	5.6e-118	430.3	Escherichia	mcbR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K13654					ko00000,ko03000				Escherichia	1MVXM@1224,1S2YM@1236,3XPWR@561,COG1802@1,COG1802@2	NA|NA|NA	K	Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy
b1451	316407.85674971	0.0	1418.7	Escherichia	yncD			ko:K02014					ko00000,ko02000	1.B.14			Escherichia	1MUIH@1224,1RQYX@1236,3XP4X@561,COG4772@1,COG4772@2	NA|NA|NA	P	siderophore transport
b1452	316407.85674972	7.5e-173	613.2	Escherichia	yncE	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0097159,GO:1901363											Escherichia	1PDS2@1224,1RPZQ@1236,3XMIW@561,COG3391@1,COG3391@2	NA|NA|NA	S	DNA binding
b1453	155864.EDL933_2195	2.2e-279	967.6	Escherichia	ansP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K11738					ko00000,ko02000	2.A.3.1.8		iAF1260.b1453,iBWG_1329.BWG_1279,iEC55989_1330.EC55989_1586,iECDH10B_1368.ECDH10B_1583,iECDH1ME8569_1439.ECDH1ME8569_1396,iECH74115_1262.ECH74115_2059,iECSP_1301.ECSP_1934,iEcDH1_1363.EcDH1_2193,iEcHS_1320.EcHS_A1540,iJO1366.b1453,iSbBS512_1146.SbBS512_E1725,iY75_1357.Y75_RS07645	Escherichia	1MUPS@1224,1RPHF@1236,3XP2B@561,COG1113@1,COG1113@2	NA|NA|NA	E	amino acid transport
b1454	316407.85674974	5.2e-118	430.3	Escherichia	yncG	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0015036,GO:0016491,GO:0016667,GO:0055114		ko:K11208					ko00000				Escherichia	1RGW9@1224,1RPXA@1236,3XQZC@561,COG0625@1,COG0625@2	NA|NA|NA	O	disulfide oxidoreductase activity
b1456	316407.1742368	0.0	1426.0	Proteobacteria													Escherichia	1NG5W@1224,COG3209@1,COG3209@2	NA|NA|NA	M	COG3209 Rhs family protein
b1459	316407.85674976	2e-138	498.8	Gammaproteobacteria													Escherichia	1MXB5@1224,1RSAV@1236,COG5433@1,COG5433@2	NA|NA|NA	L	Transposase
b1460	316407.1742372	4.6e-221	773.5	Gammaproteobacteria													Escherichia	1MXB5@1224,1RSAV@1236,COG5433@1,COG5433@2	NA|NA|NA	L	Transposase
b1461	316407.1742373	3.2e-36	157.1	Escherichia	pptA		5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000				Escherichia	1NAGG@1224,1SDP6@1236,3XQ2H@561,COG1942@1,COG1942@2	NA|NA|NA	S	Belongs to the 4-oxalocrotonate tautomerase family. PptA subfamily
b1462	316407.85674978	3.5e-108	397.5	Escherichia	yddH												Escherichia	1NB1B@1224,1RQU5@1236,3XNUH@561,COG1853@1,COG1853@2	NA|NA|NA	S	FMN binding
b1463	316407.1742382	5.8e-168	596.7	Escherichia	nhoA	GO:0003674,GO:0003824,GO:0004060,GO:0008080,GO:0008374,GO:0016407,GO:0016410,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0046990	2.3.1.118	ko:K00675					ko00000,ko01000			iECs_1301.ECs2066,iEcHS_1320.EcHS_A1547,iEcSMS35_1347.EcSMS35_1711,iZ_1308.Z2250	Escherichia	1RDF3@1224,1RQTF@1236,3XMHM@561,COG2162@1,COG2162@2	NA|NA|NA	Q	Catalyzes the acetyl-CoA-dependent N-acetylation of aromatic amines, and, probably, the O-acetylation of N- hydroxyarylamines. In vitro, catalyzes the N-acetylation of various arylamines such as aminobenzoic acid, aminophenol, aminotoluene, phenetidine, anisidine, aniline, isoniazid and 2- amino-fluorene. N-hydroxyarylamine O-acetyltransferase activity has not been assayed directly, however, NhoA activity is required for the mutagenicity of nitroaromatic compounds, suggesting that it also has O-acetyltransferase activity
b1464	316407.1742383	3.7e-173	614.0	Escherichia	yddE												Escherichia	1MUAS@1224,1S0T9@1236,3XQ51@561,COG0384@1,COG0384@2	NA|NA|NA	S	isomerase activity
b1465	155864.EDL933_2177	2.2e-125	454.9	Escherichia	narV	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1		iEC042_1314.EC042_1594,iECABU_c1320.ECABU_c17020,iECUMN_1333.ECUMN_1718,ic_1306.c1897	Escherichia	1MXGZ@1224,1RPTD@1236,3XPBJ@561,COG2181@1,COG2181@2	NA|NA|NA	C	This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit
b1466	316407.1742385	6.3e-128	463.4	Escherichia	narW			ko:K00373	ko02020,map02020				ko00000,ko00001			iECIAI1_1343.ECIAI1_1469,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594	Escherichia	1MY4E@1224,1RZMN@1236,3XNWD@561,COG2180@1,COG2180@2	NA|NA|NA	C	nitrate reductase 2
b1467	316407.1742386	0.0	1088.9	Escherichia	narY	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0032991,GO:0033554,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0050896,GO:0051536,GO:0051540,GO:0051716,GO:0055114,GO:0071944,GO:1902494	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1		iEcolC_1368.EcolC_2189	Escherichia	1MW9Q@1224,1RNMJ@1236,3XP9D@561,COG1140@1,COG1140@2	NA|NA|NA	C	This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit
b1468	316407.85674979	0.0	2632.1	Escherichia	narZ	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0008940,GO:0009061,GO:0009325,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0032991,GO:0043546,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1		iUMN146_1321.UM146_09685	Escherichia	1MW9S@1224,1RQ27@1236,3XNWC@561,COG5013@1,COG5013@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
b1469	316407.1742401	1.5e-258	898.3	Escherichia	narU	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02575	ko00910,map00910	M00615			ko00000,ko00001,ko00002,ko02000	2.A.1.8		iEcolC_1368.EcolC_2187	Escherichia	1MU27@1224,1RMUK@1236,3XNUK@561,COG2223@1,COG2223@2	NA|NA|NA	P	Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. May function as a nitrate H( ) and nitrite H( ) channel. Could confer a selective advantage during severe nutrient starvation or slow growth
b1470	316407.85674980	5.6e-58	229.9	Bacteria													Escherichia	COG4886@1,COG4886@2	NA|NA|NA	S	regulation of response to stimulus
b1471	316407.85674981	9.2e-130	469.9	Bacteria													Escherichia	COG4886@1,COG4886@2	NA|NA|NA	S	regulation of response to stimulus
b1472	316407.1742405	4.5e-48	196.8	Gammaproteobacteria													Escherichia	1MVRY@1224,1RNBS@1236,COG3203@1,COG3203@2	NA|NA|NA	M	Belongs to the Gram-negative porin family
b1473	511145.b1473	4.9e-162	577.0	Escherichia	yddG	GO:0003333,GO:0003674,GO:0005215,GO:0005302,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015179,GO:0015192,GO:0015196,GO:0015238,GO:0015318,GO:0015711,GO:0015801,GO:0015807,GO:0015823,GO:0015827,GO:0015828,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039										iBWG_1329.BWG_1294,iE2348C_1286.E2348C_1607,iECDH10B_1368.ECDH10B_1604,iECDH1ME8569_1439.ECDH1ME8569_1416,iECS88_1305.ECS88_1565,iEcDH1_1363.EcDH1_2175,iJO1366.b1473,iNRG857_1313.NRG857_07295,iUMN146_1321.UM146_09675	Escherichia	1MVGC@1224,1RMXB@1236,3XPG3@561,COG0697@1,COG0697@2	NA|NA|NA	EG	L-tyrosine transmembrane transporter activity
b1474	316407.85674982	0.0	2105.1	Escherichia	fdnG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008430,GO:0009055,GO:0009061,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030151,GO:0030288,GO:0030313,GO:0031975,GO:0032787,GO:0032991,GO:0033554,GO:0036397,GO:0042597,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:1902494	1.17.1.9,1.17.5.3	ko:K00123,ko:K08348	ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020		R00519	RC02796	ko00000,ko00001,ko01000	5.A.3.2		iECW_1372.ECW_m4203,iECs_1301.ECs2078,iUMNK88_1353.UMNK88_1879,iWFL_1372.ECW_m4203,iZ_1308.Z2236	Escherichia	1MW3N@1224,1RN6N@1236,3XM6Z@561,COG0243@1,COG0243@2,COG3383@1,COG3383@2	NA|NA|NA	C	Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar)
b1475	198214.SF1750	1.4e-177	628.6	Gammaproteobacteria													Escherichia	1MU1B@1224,1RNFG@1236,COG0437@1,COG0437@2	NA|NA|NA	C	formate dehydrogenase
b1476	155864.EDL933_2165	5.9e-120	436.8	Escherichia	fdnI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0032787,GO:0032991,GO:0036397,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0052738,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1902494		ko:K08350	ko02020,map02020				ko00000,ko00001	5.A.3.2		iEC042_1314.EC042_1608,iECED1_1282.ECED1_1627,iECNA114_1301.ECNA114_3649,iECSF_1327.ECSF_1390,iECUMN_1333.ECUMN_1730,ic_1306.c1907	Escherichia	1MXFQ@1224,1RRKV@1236,3XN1G@561,COG2864@1,COG2864@2	NA|NA|NA	C	to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. Subunit gamma is the cytochrome b556 component of the formate dehydrogenase-N, and also contains a menaquinone reduction site that receives electrons from the beta subunit (FdnH), through its hemes. Formate
b1477	1440052.EAKF1_ch0024	1.9e-43	181.4	Escherichia	yddM			ko:K21498					ko00000,ko02048				Escherichia	1N2BD@1224,1SDXN@1236,3XPWQ@561,COG3093@1,COG3093@2	NA|NA|NA	K	sequence-specific DNA binding
b1478	316407.1742410	5.4e-189	666.8	Escherichia	adhP	GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0006081,GO:0006117,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016614,GO:0016616,GO:0033554,GO:0042221,GO:0042493,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0045471,GO:0046185,GO:0046187,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0097305,GO:1901575,GO:1901700	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000			iECP_1309.ECP_1480	Escherichia	1MUTT@1224,1RPQC@1236,3XMXX@561,COG1064@1,COG1064@2	NA|NA|NA	C	acetaldehyde catabolic process
b1479	316407.85674984	0.0	1131.3	Escherichia	maeA	GO:0003674,GO:0003824,GO:0004470,GO:0004471,GO:0004473,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006094,GO:0006108,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0019318,GO:0019319,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0055114,GO:0071704,GO:1901576	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020		R00214	RC00105	ko00000,ko00001,ko01000			iSbBS512_1146.SbBS512_E1742	Escherichia	1MU0A@1224,1RQ11@1236,3XNQS@561,COG0281@1,COG0281@2	NA|NA|NA	C	malate dehydrogenase (decarboxylating) (NAD+) activity
b1480	155864.EDL933_2161	2.8e-16	90.1	Gammaproteobacteria													Escherichia	1NIKN@1224,1SHIP@1236,2EN1Q@1,33FPW@2	NA|NA|NA	J	Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein
b1481	316407.85674986	2e-32	144.4	Escherichia	bdm	GO:0008150,GO:0010638,GO:0031344,GO:0031346,GO:0033043,GO:0044087,GO:0044089,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0060491,GO:0065007,GO:1902115,GO:1902117,GO:1902208,GO:1902210											Escherichia	1N3CC@1224,1SBZ1@1236,2CPZC@1,32SK6@2,3XR4N@561	NA|NA|NA	S	positive regulation of bacterial-type flagellum assembly
b1482	198214.SF1743	1.5e-63	248.8	Gammaproteobacteria													Escherichia	1RH9U@1224,1S205@1236,COG1764@1,COG1764@2	NA|NA|NA	O	redox protein regulator of disulfide bond formation
b1483	316407.1742423	3.5e-174	617.5	Gammaproteobacteria													Escherichia	1NU4K@1224,1RRVT@1236,COG4608@1,COG4608@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
b1484	316407.1742424	1.3e-187	662.1	Escherichia	ddpD			ko:K02031	ko02024,map02024	M00239			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iECIAI1_1343.ECIAI1_1494	Escherichia	1R4KB@1224,1SMBI@1236,3XMHZ@561,COG0444@1,COG0444@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
b1485	316407.1742425	4.6e-147	527.3	Escherichia	ddpC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02034	ko02024,map02024	M00239			ko00000,ko00001,ko00002,ko02000	3.A.1.5			Escherichia	1MW3R@1224,1RSEE@1236,3XRIN@561,COG1173@1,COG1173@2	NA|NA|NA	EP	Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane
b1486	316407.1742426	1.2e-191	675.6	Escherichia	ddpB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02033	ko02024,map02024	M00239			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iECIAI39_1322.ECIAI39_1750,iECSP_1301.ECSP_1971,iZ_1308.Z2224	Escherichia	1MU8Z@1224,1RNJ1@1236,3XMU4@561,COG0601@1,COG0601@2	NA|NA|NA	EP	probably responsible for the translocation of the substrate across the membrane
b1487	316407.85674987	5.6e-302	1042.7	Gammaproteobacteria													Escherichia	1MUZH@1224,1RR8J@1236,COG0747@1,COG0747@2	NA|NA|NA	E	Extracellular solute-binding protein, family 5
b1488	316407.1742428	6e-108	396.7	Gammaproteobacteria													Escherichia	1RENK@1224,1S3SJ@1236,COG2173@1,COG2173@2	NA|NA|NA	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
b1489	316407.1742440	0.0	1600.1	Escherichia	dosP	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0008081,GO:0008144,GO:0008150,GO:0009628,GO:0016787,GO:0016788,GO:0019825,GO:0019826,GO:0020037,GO:0036094,GO:0042578,GO:0043167,GO:0043169,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0070482,GO:0071111,GO:0097159,GO:1901363	3.1.4.52	ko:K13243			R08991	RC00296	ko00000,ko01000			iG2583_1286.G2583_1852	Escherichia	1NWNJ@1224,1T2J6@1236,3XN8P@561,COG2199@1,COG2199@2,COG2200@1,COG2200@2,COG2202@1,COG2202@2	NA|NA|NA	T	Heme-based oxygen sensor protein displaying phosphodiesterase (PDE) activity toward c-di-GMP in response to oxygen availability. Involved in the modulation of intracellular c-di-GMP levels, in association with DosC which catalyzes the biosynthesis of c-di-GMP (diguanylate cyclase activity). Cyclic- di-GMP is a second messenger which controls cell surface- associated traits in bacteria. Has very poor PDE activity on cAMP but is not active with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate. Via its PDE activity on c-di-GMP, DosP regulates biofilm formation through the repression of transcription of the csgBAC operon, which encodes curli structural subunits
b1490	155864.EDL933_2150	1.9e-256	891.3	Escherichia	dosC	GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0016740,GO:0016772,GO:0016779,GO:0019825,GO:0020037,GO:0036094,GO:0042165,GO:0043167,GO:0043169,GO:0046906,GO:0048037,GO:0052621,GO:0070025,GO:0097159,GO:1901363	2.7.7.65	ko:K13069			R08057		ko00000,ko01000				Escherichia	1MVCZ@1224,1RS2H@1236,3XN9P@561,COG2199@1,COG3706@2	NA|NA|NA	T	Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus, catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules
b1491	155864.EDL933_2149	1.6e-249	868.2	Escherichia	yddW												Escherichia	1N99Y@1224,1RSIV@1236,3XM34@561,COG1649@1,COG1649@2	NA|NA|NA	S	catalytic activity
b1492	198214.SF1735	4.1e-281	973.4	Gammaproteobacteria													Escherichia	1MUP1@1224,1RR0V@1236,COG0531@1,COG0531@2	NA|NA|NA	E	amino acid
b1493	155864.EDL933_2147	2.5e-285	987.3	Escherichia	gadB	GO:0003674,GO:0003824,GO:0004351,GO:0006873,GO:0006885,GO:0008150,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019725,GO:0030003,GO:0030004,GO:0030641,GO:0042592,GO:0045852,GO:0048878,GO:0050801,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_1747,iUTI89_1310.UTI89_C1707,ic_1306.c1922	Escherichia	1MX25@1224,1RNSQ@1236,3XMMA@561,COG0076@1,COG0076@2	NA|NA|NA	E	Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria
b1494	316407.85674991	0.0	1792.3	Escherichia	pqqL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07263					ko00000,ko01000,ko01002				Escherichia	1NAH6@1224,1RNKC@1236,3XQWU@561,COG0612@1,COG0612@2	NA|NA|NA	S	Belongs to the peptidase M16 family
b1495	316407.1742453	0.0	1610.5	Escherichia	yddB												Escherichia	1MXAE@1224,1RWWH@1236,3XQNT@561,COG1629@1,COG4771@2	NA|NA|NA	P	TonB-dependent Receptor Plug Domain
b1496	316407.85674992	1.6e-310	1071.2	Escherichia	yddA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K02471	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4			Escherichia	1MW09@1224,1RPQA@1236,3XQG7@561,COG4178@1,COG4178@2	NA|NA|NA	P	ATPase activity, coupled to movement of substances
b1497	316407.1742455	1.7e-231	808.1	Escherichia	ydeM	GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0033554,GO:0043170,GO:0044238,GO:0050896,GO:0051604,GO:0051716,GO:0071704,GO:1901564		ko:K06871					ko00000				Escherichia	1MX3M@1224,1RN4R@1236,3XP4I@561,COG0641@1,COG0641@2	NA|NA|NA	C	protein maturation
b1498	316407.85674993	0.0	1145.2	Escherichia	ydeN	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K01138					ko00000,ko01000				Escherichia	1MV92@1224,1RPM3@1236,3XNAG@561,COG3119@1,COG3119@2	NA|NA|NA	P	sulfuric ester hydrolase activity
b1499	316407.85674994	1.7e-142	511.9	Escherichia	ydeO	GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141											Escherichia	1NNF1@1224,1SI85@1236,3XR55@561,COG2207@1,COG2207@2	NA|NA|NA	K	Induces the expression of gadE and mdtEF. Could also regulate the expression of other genes involved in acid resistance
b1501	316407.1742462	0.0	1535.8	Escherichia	ydeP	GO:0008150,GO:0009268,GO:0009628,GO:0010447,GO:0050896											Escherichia	1MU6B@1224,1RNXW@1236,3XNYR@561,COG0243@1,COG0243@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
b1502	316407.1742463	1.2e-171	609.0	Gammaproteobacteria													Escherichia	1RCUS@1224,1S3EA@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	cell adhesion
b1503	316407.1742464	3.9e-87	327.4	Escherichia	ydeR												Escherichia	1RC12@1224,1S36F@1236,3XRCJ@561,COG3539@1,COG3539@2	NA|NA|NA	NU	cell adhesion
b1504	316407.1742465	2.2e-93	348.2	Gammaproteobacteria													Escherichia	1N7VK@1224,1T0XP@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial protein
b1505	316407.85674995	1.9e-206	724.9	Gammaproteobacteria													Escherichia	1MUHE@1224,1RMPU@1236,COG3188@1,COG3188@2	NA|NA|NA	NU	Usher protein
b1506	316407.85674996	3e-27	127.1	Bacteria													Escherichia	COG4977@1,COG4977@2	NA|NA|NA	K	sequence-specific DNA binding
b1507	316407.85674997	5.2e-256	889.8	Escherichia	hipA	GO:0000166,GO:0000287,GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0004672,GO:0004674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0008144,GO:0008150,GO:0008152,GO:0009279,GO:0009297,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018105,GO:0018193,GO:0018209,GO:0019219,GO:0019222,GO:0019538,GO:0019867,GO:0022607,GO:0022611,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031975,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0042710,GO:0043086,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043565,GO:0043711,GO:0044010,GO:0044085,GO:0044092,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044462,GO:0044464,GO:0044764,GO:0045892,GO:0045934,GO:0046777,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051252,GO:0051253,GO:0051704,GO:0055085,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140096,GO:0140110,GO:1901265,GO:1901363,GO:1901564,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	2.7.11.1	ko:K07154					ko00000,ko01000,ko01001,ko02048				Escherichia	1MVAB@1224,1RR5N@1236,3XQT8@561,COG3550@1,COG3550@2	NA|NA|NA	S	Toxic component of a type II toxin-antitoxin (TA) system, first identified by mutations that increase production of persister cells, a fraction of cells that are phenotypic variants not killed by antibiotics, which lead to multidrug tolerance. Persistence may be ultimately due to global remodeling of the persister cell's ribosomes. Phosphorylates Glu-tRNA-ligase (AC P04805, gltX, on 'Ser-239') in vivo. Phosphorylation of GltX prevents it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to persistence and multidrug resistance. Once the level of HipA exceeds a threshold cells become dormant, and the length of dormancy is determined by how much HipA levels exceed the threshold. The hipA7 mutation (a double G22S D291A mutation) leads to increased generation of persister cells (cells that survive antibiotic treatment) probably by entering into a dormant state, as well as cold-sensitivity. Wild-type cells produce persisters at a frequency of 10(-6) to 10(-5) whereas hipA7 cells produce about 100-fold more persisters. hipA7 decreases the affinity for antitoxin HipB, leading to increased HipA levels and persistence
b1508	316407.1742468	1.3e-41	175.3	Escherichia	hipB	GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K15773					ko00000,ko02048,ko03000				Escherichia	1N8RD@1224,1SEFV@1236,3XR3Z@561,COG1396@1,COG1396@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the toxic effect of cognate toxin HipA. Also neutralizes the toxic effect of non- cognate toxin YjjJ. Binds to operator sites with the consensus sequence 5-'TATCCN(8)GGATA-3' to repress the hipBA operon promoter
b4696	316407.85674998	0.0	2208.3	Gammaproteobacteria													Escherichia	1QUUN@1224,1STEE@1236,COG2911@1,COG2911@2,COG3210@1,COG3210@2	NA|NA|NA	U	Outer membrane autotransporter
b1511	316407.1742480	2.2e-311	1074.7	Escherichia	lsrK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009372,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0042710,GO:0044010,GO:0044237,GO:0044764,GO:0051704,GO:0071518	2.7.1.189	ko:K11216	ko02024,map02024		R11183	RC00002,RC00017	ko00000,ko00001,ko01000				Escherichia	1MWS5@1224,1RRKR@1236,3XQXQ@561,COG1070@1,COG1070@2	NA|NA|NA	G	Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3- dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position
b1512	316407.85674999	2.9e-152	544.7	Escherichia	lsrR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:1990837,GO:2000112,GO:2000142,GO:2001141		ko:K11531	ko02024,ko02026,map02024,map02026				ko00000,ko00001,ko03000				Escherichia	1MWHQ@1224,1RRDZ@1236,3XQXN@561,COG2390@1,COG2390@2	NA|NA|NA	K	Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI- 2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes
b1513	316407.1742490	8e-285	985.7	Escherichia	lsrA			ko:K10558	ko02010,ko02024,map02010,map02024	M00219			ko00000,ko00001,ko00002,ko02000	3.A.1.2.8			Escherichia	1MU22@1224,1RPSU@1236,3XQS0@561,COG1129@1,COG1129@2	NA|NA|NA	G	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system
b1514	316407.1742491	1e-179	636.0	Escherichia	lsrC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K10556	ko02010,ko02024,map02010,map02024	M00219			ko00000,ko00001,ko00002,ko02000	3.A.1.2.8		iEKO11_1354.EKO11_2302	Escherichia	1MWN4@1224,1RQFP@1236,3XQG6@561,COG1172@1,COG1172@2	NA|NA|NA	U	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane
b1515	198214.SF1585	1e-171	609.4	Gammaproteobacteria													Escherichia	1MV4F@1224,1RQ84@1236,COG1172@1,COG1172@2	NA|NA|NA	U	Belongs to the binding-protein-dependent transport system permease family
b1516	316407.85675000	3.1e-192	677.6	Escherichia	lsrB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K10555	ko02010,ko02024,map02010,map02024	M00219			ko00000,ko00001,ko00002,ko02000	3.A.1.2.8			Escherichia	1MUAT@1224,1RXX7@1236,3XPVP@561,COG1879@1,COG1879@2	NA|NA|NA	G	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases
b1517	316407.85675001	4e-164	583.9	Escherichia	lsrF	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	2.3.1.245	ko:K08321	ko02024,map02024				ko00000,ko00001,ko01000				Escherichia	1MWJW@1224,1RYC1@1236,3XQD5@561,COG1830@1,COG1830@2	NA|NA|NA	H	Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA
b1518	155864.EDL933_2120	1.2e-48	198.7	Escherichia	lsrG	GO:0002952,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016853,GO:0044424,GO:0044444,GO:0044464,GO:0055114	5.3.1.32	ko:K11530	ko02024,map02024				ko00000,ko00001,ko01000				Escherichia	1RI7W@1224,1S61K@1236,3XR3S@561,COG1359@1,COG1359@2	NA|NA|NA	S	Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD)
b1519	316407.85675003	5.9e-148	530.0	Escherichia	tam	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0030798,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.144	ko:K00598					ko00000,ko01000			iECABU_c1320.ECABU_c17460,iSDY_1059.SDY_1625,ic_1306.c1942	Escherichia	1Q2Y3@1224,1RPKV@1236,3XND4@561,COG4106@1,COG4106@2	NA|NA|NA	J	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate
b1520	316407.85675004	6.9e-167	593.2	Escherichia	yneE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08994					ko00000,ko02000	1.A.46.2			Escherichia	1MX91@1224,1S0QU@1236,3XM7T@561,COG3781@1,COG3781@2	NA|NA|NA	S	Bestrophin, RFP-TM, chloride channel
b1521	316407.1742495	1.4e-283	981.5	Escherichia	uxaB	GO:0000166,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0048037,GO:0050662,GO:0051287,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.1.1.58	ko:K00041	ko00040,ko01100,map00040,map01100	M00631	R02555	RC00085	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c17480	Escherichia	1MVZ7@1224,1RQX5@1236,3XM9T@561,COG0246@1,COG0246@2	NA|NA|NA	G	Belongs to the mannitol dehydrogenase family. UxaB subfamily
b1522	316407.85675005	1.6e-171	608.6	Escherichia	yneF	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032879,GO:0040012,GO:0044464,GO:0050789,GO:0050794,GO:0051270,GO:0065007,GO:0071944,GO:1902021,GO:2000145										ic_1306.c1945	Escherichia	1QYXH@1224,1T3WR@1236,3XRIA@561,COG2199@1,COG2199@2	NA|NA|NA	T	regulation of bacterial-type flagellum-dependent cell motility
b1523	316407.85675006	5.6e-64	250.0	Escherichia	yneG												Escherichia	1RGW8@1224,1S6NK@1236,2DMJC@1,32RYJ@2,3XPTR@561	NA|NA|NA	S	Domain of unknown function (DUF4186)
b1524	155864.EDL933_2114	1.2e-171	609.0	Escherichia	glsA2	GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0040008,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0045926,GO:0046394,GO:0046395,GO:0048519,GO:0050789,GO:0065007,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230		R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000			iB21_1397.B21_01492,iECBD_1354.ECBD_2118,iECB_1328.ECB_01481,iECD_1391.ECD_01481	Escherichia	1MWB5@1224,1RMY9@1236,3XNTI@561,COG2066@1,COG2066@2	NA|NA|NA	E	Belongs to the glutaminase family
b1525	316407.85675007	3.2e-264	917.1	Escherichia	sad	GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0032787,GO:0034641,GO:0042133,GO:0042135,GO:0042402,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.16,1.2.1.24	ko:K08324	ko00250,ko00650,ko00760,ko01100,ko01120,map00250,map00650,map00760,map01100,map01120		R00713,R00714	RC00080	ko00000,ko00001,ko01000			iECUMN_1333.ECUMN_1793	Escherichia	1MU1V@1224,1RMBQ@1236,3XNDH@561,COG1012@1,COG1012@2	NA|NA|NA	C	Catalyzes the NAD( )-dependent oxidation of succinate semialdehyde to succinate. It acts preferentially with NAD as cosubstrate but can also use NADP. Prevents the toxic accumulation of succinate semialdehyde (SSA) and plays an important role when arginine and putrescine are used as the sole nitrogen or carbon sources
b1526	316407.1742500	2.3e-167	594.7	Escherichia	yneJ	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1N8HZ@1224,1RR4Z@1236,3XP0D@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
b1527	316407.85675008	4.4e-216	756.9	Escherichia	yneK												Escherichia	1NR5J@1224,1SJVZ@1236,2EWD9@1,33PRV@2,3XQHE@561	NA|NA|NA		
b1528	316407.1742501	1.7e-205	721.8	Escherichia	sotB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08159					ko00000,ko02000	2.A.1.2.15,2.A.1.2.18		iEcSMS35_1347.EcSMS35_1642	Escherichia	1MU9G@1224,1RPHV@1236,3XNX7@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b1529	198214.SF1565	3e-111	407.9	Gammaproteobacteria													Escherichia	1MV1C@1224,1RPM8@1236,COG2095@1,COG2095@2	NA|NA|NA	U	UPF0056 membrane protein
b1530	316407.1742512	1e-75	289.3	Escherichia	marR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0044212,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071236,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03712					ko00000,ko03000				Escherichia	1N7BV@1224,1S2AX@1236,3XMZ4@561,COG1846@1,COG1846@2	NA|NA|NA	K	Multiple antibiotic resistance protein MarR
b1531	155864.EDL933_2106	3.4e-67	260.8	Escherichia	marA	GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0006081,GO:0006082,GO:0006089,GO:0006355,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009635,GO:0009636,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019219,GO:0019222,GO:0019243,GO:0019249,GO:0019752,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032787,GO:0032991,GO:0032993,GO:0035690,GO:0036245,GO:0042180,GO:0042182,GO:0042221,GO:0042493,GO:0042802,GO:0042803,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046185,GO:0046394,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051596,GO:0051716,GO:0060255,GO:0061727,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0072330,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:0140110,GO:1901363,GO:1901562,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1901654,GO:1901655,GO:1901700,GO:1901701,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K13632	ko01503,map01503	M00647,M00746			ko00000,ko00001,ko00002,ko01504,ko03000				Escherichia	1QWBW@1224,1T2T8@1236,3XRN2@561,COG4977@1,COG4977@2	NA|NA|NA	K	May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF
b1532	316407.1742514	2e-32	144.4	Escherichia	marB	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K13630					ko00000				Escherichia	1N7UE@1224,1SFHP@1236,2E68Q@1,330WV@2,3XQ6F@561	NA|NA|NA	S	response to antibiotic
b1533	316407.85675011	1.3e-157	562.4	Escherichia	eamA	GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015562,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0032973,GO:0033228,GO:0034220,GO:0042883,GO:0044425,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0140115,GO:1903712,GO:1903825,GO:1905039		ko:K15268					ko00000,ko02000	2.A.7.3.2		iECIAI39_1322.ECIAI39_1835	Escherichia	1MVKG@1224,1RM8T@1236,3XP05@561,COG0697@1,COG0697@2	NA|NA|NA	EG	May be an export pump for cysteine and other metabolites of the cysteine pathway (such as N-acetyl-L-serine (NAS) and O- acetyl-L-serine (OAS)), and for other amino acids and their metabolites
b1534	316407.85675012	8.3e-213	746.1	Escherichia	ydeE	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0016020,GO:0022857,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:1904680											Escherichia	1N0KT@1224,1RYZC@1236,3XMUC@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b4599	35703.DQ02_20540	3e-09	66.2	Citrobacter													Escherichia	1PKDA@1224,1TM2C@1236,2ETZ7@1,30YHR@2,3WZP9@544	NA|NA|NA		
b1535	316407.85675013	8.2e-173	612.8	Escherichia	ydeH	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0008270,GO:0009987,GO:0010639,GO:0016740,GO:0016772,GO:0016779,GO:0022610,GO:0031344,GO:0031345,GO:0031589,GO:0032879,GO:0033043,GO:0042710,GO:0042802,GO:0043167,GO:0043169,GO:0043708,GO:0043709,GO:0043900,GO:0043902,GO:0044010,GO:0044087,GO:0044464,GO:0044764,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051270,GO:0051271,GO:0051704,GO:0052621,GO:0060187,GO:0060491,GO:0065007,GO:0090605,GO:0090609,GO:1900190,GO:1900192,GO:1900231,GO:1900233,GO:1902115,GO:1902116,GO:1902208,GO:1902209	2.7.7.65	ko:K13069			R08057		ko00000,ko01000				Escherichia	1R7KA@1224,1RS1K@1236,3XMPS@561,COG2199@1,COG3706@2	NA|NA|NA	T	swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
b1536	316407.1742519	2.7e-67	261.2	Escherichia	ydeI	GO:0000302,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0009987,GO:0010035,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044011,GO:0044764,GO:0046677,GO:0050896,GO:0051703,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071236,GO:0090605,GO:0090609,GO:0097237,GO:1901700,GO:1901701											Escherichia	1REUG@1224,1S54G@1236,3XQ1V@561,COG3111@1,COG3111@2	NA|NA|NA	S	single-species biofilm formation on inanimate substrate
b1537	316407.1742520	3.4e-86	324.3	Escherichia	ydeJ												Escherichia	1REN7@1224,1S531@1236,3XR60@561,COG1546@1,COG1546@2	NA|NA|NA	S	Competence-damaged protein
b1538	316407.1742521	0.0	1372.5	Escherichia	dcp	GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.15.5	ko:K01284					ko00000,ko01000,ko01002				Escherichia	1MU1K@1224,1RMXI@1236,3XMH4@561,COG0339@1,COG0339@2	NA|NA|NA	E	metalloendopeptidase activity
b1539	316407.1742536	1.5e-140	505.4	Escherichia	ydfG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019860,GO:0031132,GO:0034641,GO:0035527,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.1.1.381	ko:K16066	ko00240,ko00260,ko01100,map00240,map00260,map01100		R09289,R10851,R10852	RC00087,RC00525,RC03288	ko00000,ko00001,ko01000				Escherichia	1MUF8@1224,1RMKM@1236,3XNZ4@561,COG4221@1,COG4221@2	NA|NA|NA	S	NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP- dependent oxidation of L-allo-threonine to L-2-amino-3-keto- butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3- hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L- glycerate. Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid. YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradation since both are able to detoxify malonic semialdehyde
b1540	155864.EDL933_2093	2.1e-123	448.4	Escherichia	ydfH	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K22293					ko00000,ko03000				Escherichia	1MWG2@1224,1RNYJ@1236,3XNRB@561,COG1802@1,COG1802@2	NA|NA|NA	K	transcriptional regulator
b1541	1440052.EAKF1_ch4497c	2.5e-29	134.0	Escherichia	ydfZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1NFFH@1224,1SG5K@1236,2C4ZZ@1,3308E@2,3XQ4X@561	NA|NA|NA	S	YdfZ protein
b1542	316407.1742538	3.2e-283	980.3	Escherichia	ydfI	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114											Escherichia	1MVZ7@1224,1RNIZ@1236,3XME0@561,COG0246@1,COG0246@2	NA|NA|NA	G	Belongs to the mannitol dehydrogenase family
b1543	316407.1742544	7e-234	816.2	Escherichia	ydfJ	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K08173					ko00000,ko02000	2.A.1.6			Escherichia	1MU46@1224,1RNC9@1236,3XQW9@561,COG0477@1,COG0477@2	NA|NA|NA	P	Sugar (and other) transporter
b1544	316407.85675015	7.1e-36	156.0	Gammaproteobacteria													Escherichia	1N9CF@1224,1SFBX@1236,2E5B9@1,3303D@2	NA|NA|NA	K	response to cold
b1545	316407.1742545	2e-103	381.7	Escherichia	pinQ	GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360		ko:K14060					ko00000				Escherichia	1RA0V@1224,1RPSK@1236,3XR8X@561,COG1961@1,COG1961@2	NA|NA|NA	L	recombinase activity
b1546	316407.1742546	5e-107	393.7	Escherichia	tfaQ												Escherichia	1MYT5@1224,1S7KD@1236,3XPJT@561,COG2110@1,COG2110@2	NA|NA|NA	S	Tail fiber assembly protein homolog from lambdoid prophage
b1547	316407.1742547	3.2e-130	471.5	Escherichia	stfQ												Escherichia	1RFCQ@1224,1S5SP@1236,3XQHT@561,COG5301@1,COG5301@2	NA|NA|NA	M	tail fiber protein
b1548	316407.1742548	1.7e-99	368.6	Escherichia	nohB			ko:K22014					ko00000				Escherichia	1RFQ1@1224,1S33Z@1236,3XQB6@561,COG4220@1,COG4220@2	NA|NA|NA	L	DNA packaging
b4533	316407.85675016	3.9e-34	150.2	Gammaproteobacteria													Escherichia	1NNEJ@1224,1SJ98@1236,2DR7X@1,33AKV@2	NA|NA|NA	S	Domain of unknown function (DUF3950)
b1549	316407.85675017	2.1e-70	271.6	Bacteria													Escherichia	COG5562@1,COG5562@2	NA|NA|NA	E	phage envelope protein
b1550	316407.85675018	1.3e-21	108.2	Gammaproteobacteria													Escherichia	1NEUJ@1224,1SFD3@1236,2BVP3@1,332DR@2	NA|NA|NA	S	Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation
b1551	316407.85675019	2.1e-20	104.0	Gammaproteobacteria													Escherichia	1N41W@1224,1SBBU@1236,2E08X@1,32VWI@2	NA|NA|NA		
b4724	362663.ECP_0988	6.4e-19	99.4	Gammaproteobacteria													Escherichia	1P6C3@1224,1ST99@1236,28YUP@1,2ZKMW@2	NA|NA|NA		
b1552	199310.c3177	6.1e-34	149.4	Escherichia	cspI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0044424,GO:0044444,GO:0044464,GO:0050896		ko:K03704					ko00000,ko03000				Escherichia	1N6Q5@1224,1SCA7@1236,3XQ03@561,COG1278@1,COG1278@2	NA|NA|NA	K	Binds to and stimulates the transcription of the CCAAT- containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3'
b1553	316407.85675020	1.1e-81	309.3	Gammaproteobacteria													Escherichia	1RIWH@1224,1S7QI@1236,2EDZZ@1,31C0Y@2	NA|NA|NA	S	Protein of unknown function (DUF2514)
b4689	511145.b4689	7.5e-39	166.0	Gammaproteobacteria													Escherichia	1P4G0@1224,1SU2Y@1236,2BX3T@1,2ZU32@2	NA|NA|NA		
b1554	316407.85675021	1.2e-102	379.0	Escherichia	rrrQ		3.2.1.17	ko:K01185					ko00000,ko01000				Escherichia	1RA0W@1224,1S2XG@1236,3XQB7@561,COG3772@1,COG3772@2	NA|NA|NA	G	Corresponds to locus_tag
b1555	502347.ESCAB7627_1257	2e-25	121.7	Escherichia	ydfR												Escherichia	1P4ZI@1224,1SUPV@1236,2DEGM@1,2ZMXP@2,3XR1P@561	NA|NA|NA	S	Protein of unknown function (DUF1327)
b1556	316407.85675023	8.9e-33	145.6	Escherichia	essQ												Escherichia	1NAY0@1224,1SBWM@1236,2E3SS@1,32YQ9@2,3XRH5@561	NA|NA|NA	S	Lysis protein S homolog from lambdoid prophage
b1557	316407.1742552	1.1e-33	148.7	Gammaproteobacteria													Escherichia	1N6Q5@1224,1SCA7@1236,COG1278@1,COG1278@2	NA|NA|NA	K	Cold shock
b1558	199310.c3185	1.3e-31	141.7	Bacteria													Escherichia	COG1278@1,COG1278@2	NA|NA|NA	K	Cold shock
b1559	316407.1742554	3e-144	517.7	Escherichia	quuQ												Escherichia	1QHJU@1224,1RQCY@1236,3XPWT@561,COG0484@1,COG0484@2	NA|NA|NA	K	Antitermination protein Q
b1560	316407.1742555	1.3e-204	718.8	Escherichia	ydfU												Escherichia	1N0FM@1224,1RP42@1236,3XQGJ@561,COG1403@1,COG1403@2	NA|NA|NA	V	Corresponds to locus_tag
b1561	316407.1742556	5.1e-40	169.9	Escherichia	rem												Escherichia	1NYHP@1224,1SQGD@1236,2FA95@1,342HU@2,3XR76@561	NA|NA|NA		
b1562	316407.1742557	2.9e-17	93.6	Escherichia	hokD	GO:0005575,GO:0008150,GO:0008219,GO:0009987,GO:0016020		ko:K18919					ko00000,ko02048				Escherichia	1ND6M@1224,1SFSG@1236,2DQ3V@1,334M8@2,3XR9G@561	NA|NA|NA	S	When overexpressed kills the cells from the inside by interfering with a vital function in the cell membrane
b1563	1006000.GKAS_04730	1.8e-44	184.9	Gammaproteobacteria													Escherichia	1MZ76@1224,1S8RR@1236,COG2026@1,COG2026@2	NA|NA|NA	DJ	Cytotoxic translational repressor of toxin-antitoxin stability system
b1564	1006000.GKAS_04689	4.7e-35	153.3	Gammaproteobacteria													Escherichia	1N8G2@1224,1SCQI@1236,COG3077@1,COG3077@2	NA|NA|NA	L	bifunctional antitoxin of the RelE-RelB toxin-antitoxin system transcriptional repressor
b1567	481805.EcolC_2069	6e-20	102.4	Gammaproteobacteria													Escherichia	1MWVQ@1224,1RN12@1236,COG2801@1,COG2801@2,COG3415@1,COG3415@2	NA|NA|NA	L	PFAM Integrase catalytic
b1568	316407.85675027	4.5e-48	196.8	Gammaproteobacteria													Escherichia	1NA33@1224,1SG50@1236,2EE2H@1,337X7@2	NA|NA|NA	S	Putative bacterial toxin ydaT
b1569	316407.1742571	3.5e-35	153.7	Escherichia	dicC			ko:K22302					ko00000,ko03000				Escherichia	1QINT@1224,1TGI5@1236,2AV39@1,31KTA@2,3XR4E@561	NA|NA|NA	K	This protein is a repressor of division inhibition gene dicB
b1570	316407.1742572	2.5e-68	264.6	Escherichia	dicA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K22300					ko00000,ko03000				Escherichia	1N2U8@1224,1SBKZ@1236,3XR8U@561,COG1396@1,COG1396@2	NA|NA|NA	K	This protein is a repressor of division inhibition gene dicB
b1571	1440052.EAKF1_ch0488	1.5e-21	107.8	Escherichia													Escherichia	1NCTS@1224,1SEZR@1236,2E72D@1,331M0@2,3XR6X@561	NA|NA|NA	S	Protein of unknown function (DUF1391)
b1572	316407.1742574	1.6e-13	80.9	Escherichia													Escherichia	1QIRK@1224,1TGKY@1236,2DK2U@1,3089M@2,3XRAA@561	NA|NA|NA		
b1573	1440052.EAKF1_ch0489	5.8e-32	142.9	Escherichia	ydfC												Escherichia	1QIP0@1224,1TGIC@1236,2AV3H@1,31KTH@2,3XR4Z@561	NA|NA|NA		
b1575	316407.1742576	3.7e-27	126.7	Escherichia	dicB	GO:0008150,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051302,GO:0051782,GO:0065007		ko:K22304					ko00000				Escherichia	1QIQA@1224,1TGJM@1236,2AV4R@1,31KUY@2,3XR7H@561	NA|NA|NA	D	Division inhibition protein dicB
b1576	511145.b1576	7.6e-28	129.0	Escherichia		GO:0001906,GO:0001907,GO:0008150,GO:0016032,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192											Escherichia	1NIY5@1224,1SHDX@1236,2EHIM@1,33BAK@2,3XR7I@561	NA|NA|NA	S	Protein of unknown function (DUF1482)
b1577	316407.85675028	3.6e-179	634.0	Bacteria													Escherichia	COG0847@1,COG0847@2	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
b1578	178901.AmDm5_3104	3.8e-127	460.7	Alphaproteobacteria													Escherichia	1MY62@1224,2U0GY@28211,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
b1579	316407.85675030	9.8e-230	802.4	Escherichia				ko:K14059					ko00000				Escherichia	1MVZB@1224,1RP4Y@1236,3XM9F@561,COG0582@1,COG0582@2	NA|NA|NA	L	Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome (By similarity)
b4534	481805.EcolC_2051	6.8e-13	78.6	Bacteria													Escherichia	COG0477@1,COG0477@2	NA|NA|NA	EGP	Major facilitator Superfamily
b1580	316407.1742581	7.4e-194	682.9	Escherichia	rspB		1.1.1.380	ko:K08322	ko00040,ko01100,map00040,map01100		R10848	RC00085	ko00000,ko00001,ko01000				Escherichia	1MWX0@1224,1SYGT@1236,3XQPI@561,COG1063@1,COG1063@2	NA|NA|NA	C	zinc ion binding
b1581	316407.1742582	4.3e-249	866.7	Escherichia	rspA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0008927,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0071704,GO:1901575	4.2.1.8	ko:K08323	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000				Escherichia	1MURK@1224,1RNRB@1236,3XP82@561,COG4948@1,COG4948@2	NA|NA|NA	M	Has low D-mannonate dehydratase activity (in vitro), suggesting that this is not a physiological substrate and that it has no significant role in D-mannonate degradation in vivo. Has no detectable activity with a panel of 70 other acid sugars (in vitro)
b1582	316407.85675031	3.3e-55	220.7	Escherichia	ynfA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K09771					ko00000,ko02000	2.A.7.26			Escherichia	1MZI8@1224,1SA4U@1236,3XPXU@561,COG1742@1,COG1742@2	NA|NA|NA	S	Uncharacterised BCR, YnfA/UPF0060 family
b1583	316407.85675032	1.2e-55	222.2	Escherichia	ynfB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944											Escherichia	1N0YE@1224,1S9BH@1236,2CSJ8@1,32SRB@2,3XPPX@561	NA|NA|NA	S	Belongs to the UPF0482 family
b1584	155864.EDL933_2534	1.9e-103	381.7	Escherichia	speG	GO:0000287,GO:0003674,GO:0003824,GO:0004145,GO:0005488,GO:0005515,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0022607,GO:0034641,GO:0042402,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0046872,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901565,GO:1901575	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000			iAF1260.b1584,iB21_1397.B21_01543,iBWG_1329.BWG_1398,iECBD_1354.ECBD_2062,iECB_1328.ECB_01553,iECDH10B_1368.ECDH10B_1717,iECDH1ME8569_1439.ECDH1ME8569_1527,iECD_1391.ECD_01553,iECH74115_1262.ECH74115_2293,iECIAI1_1343.ECIAI1_1634,iECO103_1326.ECO103_1723,iECO111_1330.ECO111_2051,iECSE_1348.ECSE_1705,iECSP_1301.ECSP_2148,iECW_1372.ECW_m1749,iECs_1301.ECs2290,iEKO11_1354.EKO11_2194,iETEC_1333.ETEC_1618,iEcDH1_1363.EcDH1_2059,iEcE24377_1341.EcE24377A_1791,iEcHS_1320.EcHS_A1657,iEcolC_1368.EcolC_2046,iG2583_1286.G2583_1978,iJO1366.b1584,iJR904.b1584,iWFL_1372.ECW_m1749,iY75_1357.Y75_RS08305,iZ_1308.Z2571	Escherichia	1PDMH@1224,1RPZ4@1236,3XMEZ@561,COG1670@1,COG1670@2	NA|NA|NA	J	Involved in the protection against polyamine toxicity by regulating their concentration. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine
b1585	198214.SF1595	1.2e-131	475.7	Gammaproteobacteria													Escherichia	1R524@1224,1RQH0@1236,28IUM@1,2Z8TA@2	NA|NA|NA	M	Uncharacterised protein family (UPF0257)
b1586	316407.85675035	1.4e-47	195.3	Escherichia	ynfD												Escherichia	1N0CU@1224,1S9NS@1236,2CTGV@1,32STG@2,3XPU3@561	NA|NA|NA	S	Protein of unknown function (DUF1161)
b1587	316407.1742610	0.0	1660.2	Gammaproteobacteria													Escherichia	1NR6J@1224,1RMVE@1236,COG0243@1,COG0243@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
b1588	316407.85675036	0.0	1675.2	Gammaproteobacteria													Escherichia	1NR6J@1224,1RMVE@1236,COG0243@1,COG0243@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
b1589	155864.EDL933_2539	5.2e-126	456.8	Escherichia	ynfG			ko:K07311					ko00000,ko02000	5.A.3.3			Escherichia	1MU5T@1224,1RPIC@1236,3XQV9@561,COG0437@1,COG0437@2	NA|NA|NA	C	Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds
b1590	316407.85675037	2.5e-155	554.7	Escherichia	ynfH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07312					ko00000,ko02000	5.A.3.3		iE2348C_1286.E2348C_1674,iECNA114_1301.ECNA114_1636,iECO103_1326.ECO103_1729,iECSF_1327.ECSF_1450	Escherichia	1PA8U@1224,1RRGH@1236,3XQCX@561,COG3302@1,COG3302@2	NA|NA|NA	S	Dmso reductase anchor subunit
b1591	155864.EDL933_2541	2e-117	428.3	Escherichia	dmsD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098552,GO:0098562											Escherichia	1RF2Y@1224,1S3Q8@1236,3XMUD@561,COG3381@1,COG3381@2	NA|NA|NA	S	Required for biogenesis assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding-maturation pathway for the substrate protein
b1592	316407.85675038	1.3e-227	795.4	Escherichia	clcB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03281					ko00000	2.A.49		iECH74115_1262.ECH74115_2303,iECP_1309.ECP_1536,iECSP_1301.ECSP_2156,iECW_1372.ECW_m1757,iG2583_1286.G2583_1986,iWFL_1372.ECW_m1757	Escherichia	1MV4K@1224,1RQZQ@1236,3XN0X@561,COG0038@1,COG0038@2	NA|NA|NA	P	Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response
b1593	155864.EDL933_2544	1.1e-124	452.6	Escherichia	bioD2	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000				Escherichia	1NPX5@1224,1RRRI@1236,3XMEG@561,COG0132@1,COG0132@2	NA|NA|NA	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
b1594	316407.1742617	3.9e-226	790.4	Escherichia	mlc	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K15545					ko00000,ko03000				Escherichia	1MX6M@1224,1RNZ1@1236,3XMPM@561,COG1940@1,COG1940@2	NA|NA|NA	K	Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT
b1595	316407.1742618	1.4e-164	585.5	Escherichia	ynfL	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141											Escherichia	1MXRP@1224,1RQP1@1236,3XNTE@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
b1596	316407.1742630	2.8e-211	741.1	Escherichia	ynfM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08224					ko00000,ko02000	2.A.1.36			Escherichia	1MWFH@1224,1RPAT@1236,3XNEU@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b1598	316407.85675041	2e-157	561.6	Escherichia	ydgD			ko:K04775					ko00000,ko01000,ko01002				Escherichia	1PDS4@1224,1RQNX@1236,3XN03@561,COG3591@1,COG3591@2	NA|NA|NA	E	Belongs to the peptidase S1B family
b1599	155864.EDL933_2550	1.5e-50	205.3	Escherichia	mdtI	GO:0003674,GO:0005215,GO:0005326,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015199,GO:0015203,GO:0015220,GO:0015291,GO:0015297,GO:0015606,GO:0015651,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0015846,GO:0015848,GO:0015871,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031460,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072349,GO:0072488,GO:0098655,GO:1902047,GO:1903711		ko:K11742		M00711			ko00000,ko00002,ko02000	2.A.7.1.9			Escherichia	1RIBK@1224,1S68D@1236,3XPW5@561,COG2076@1,COG2076@2	NA|NA|NA	P	Catalyzes the excretion of spermidine
b1600	155864.EDL933_2551	4.4e-56	223.8	Escherichia	mdtJ	GO:0003674,GO:0005215,GO:0005326,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015199,GO:0015203,GO:0015220,GO:0015291,GO:0015297,GO:0015606,GO:0015651,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0015846,GO:0015848,GO:0015871,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031460,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072349,GO:0072488,GO:0098655,GO:1902047,GO:1903711		ko:K11743		M00711			ko00000,ko00002,ko02000	2.A.7.1.9		iAPECO1_1312.APECO1_683,iB21_1397.B21_01559,iBWG_1329.BWG_1415,iEC042_1314.EC042_1748,iEC55989_1330.EC55989_1765,iECBD_1354.ECBD_2046,iECB_1328.ECB_01569,iECDH10B_1368.ECDH10B_1733,iECDH1ME8569_1439.ECDH1ME8569_1543,iECD_1391.ECD_01569,iECED1_1282.ECED1_1769,iECH74115_1262.ECH74115_2310,iECIAI1_1343.ECIAI1_1650,iECNA114_1301.ECNA114_1647,iECO111_1330.ECO111_2069,iECO26_1355.ECO26_2304,iECOK1_1307.ECOK1_1718,iECP_1309.ECP_1544,iECS88_1305.ECS88_1645,iECSE_1348.ECSE_1721,iECSF_1327.ECSF_1460,iECSP_1301.ECSP_2164,iECW_1372.ECW_m1765,iECs_1301.ECs2306,iEKO11_1354.EKO11_2178,iETEC_1333.ETEC_1634,iEcDH1_1363.EcDH1_2043,iEcE24377_1341.EcE24377A_1807,iEcHS_1320.EcHS_A1674,iEcSMS35_1347.EcSMS35_1599,iEcolC_1368.EcolC_2030,iG2583_1286.G2583_1994,iJO1366.b1600,iLF82_1304.LF82_1301,iNRG857_1313.NRG857_08015,iSBO_1134.SBO_1536,iSDY_1059.SDY_1553,iSFV_1184.SFV_1615,iSF_1195.SF1621,iSFxv_1172.SFxv_1817,iSSON_1240.SSON_1560,iS_1188.S1753,iSbBS512_1146.SbBS512_E1786,iUMN146_1321.UM146_09165,iUMNK88_1353.UMNK88_2059,iUTI89_1310.UTI89_C1788,iWFL_1372.ECW_m1765,iY75_1357.Y75_RS08390,iZ_1308.Z2594	Escherichia	1RJKJ@1224,1S6SR@1236,3XPT1@561,COG2076@1,COG2076@2	NA|NA|NA	P	Catalyzes the excretion of spermidine
b1601	198214.SF1622	4.7e-172	610.5	Gammaproteobacteria													Escherichia	1MXXU@1224,1RQCM@1236,COG0628@1,COG0628@2	NA|NA|NA	T	permease
b1602	155864.EDL933_2553	4.7e-252	876.7	Escherichia	pntB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000			iSBO_1134.SBO_1534	Escherichia	1MUP4@1224,1RMR4@1236,3XN49@561,COG1282@1,COG1282@2	NA|NA|NA	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
b1603	316407.1742643	3.7e-282	976.9	Escherichia	pntA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0031224,GO:0031226,GO:0034641,GO:0036094,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000			iEcE24377_1341.EcE24377A_1810	Escherichia	1MVXU@1224,1RN23@1236,3XMK7@561,COG3288@1,COG3288@2	NA|NA|NA	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
b1604	316407.85675042	5.8e-169	600.1	Escherichia	ydgH												Escherichia	1MWCS@1224,1RN42@1236,28I6Q@1,2Z89M@2,3XN7G@561	NA|NA|NA	S	Protein of unknown function (DUF1471)
b1605	198214.SF1626	1.5e-250	871.7	Gammaproteobacteria													Escherichia	1MUA2@1224,1RNND@1236,COG0531@1,COG0531@2	NA|NA|NA	E	Arginine ornithine antiporter
b1606	155864.EDL933_2558	2.2e-136	491.5	Escherichia	folM	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0055114,GO:0071172	1.5.1.3,1.5.1.50	ko:K13938	ko00670,ko00790,ko01100,map00670,map00790,map01100		R00936,R00939,R11019	RC00109,RC03327	ko00000,ko00001,ko01000			iECUMN_1333.ECUMN_1894	Escherichia	1MUUV@1224,1RPGM@1236,3XP7I@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate
b1607	155864.EDL933_2559	5.4e-53	213.4	Escherichia	ydgC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RH8C@1224,1S69X@1236,3XPPD@561,COG3136@1,COG3136@2	NA|NA|NA	S	GlpM protein
b1608	316407.1742647	9.7e-132	476.1	Escherichia	rstA			ko:K07661	ko02020,map02020	M00446			ko00000,ko00001,ko00002,ko02022				Escherichia	1Q2S0@1224,1RQZZ@1236,3XMQA@561,COG0745@1,COG0745@2	NA|NA|NA	K	transcriptional Regulatory protein
b1609	316407.1742648	2.5e-247	860.9	Escherichia	rstB	GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07639	ko02020,map02020	M00446			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1N9SU@1224,1RMF5@1236,3XN6Q@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
b1610	316407.1742649	8.3e-176	622.9	Escherichia	tus	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006274,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034645,GO:0043111,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0071807,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113		ko:K10748					ko00000,ko03032				Escherichia	1NE22@1224,1RS77@1236,28I61@1,2Z895@2,3XNM8@561	NA|NA|NA	J	Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence
b1611	316407.1742650	4.5e-266	923.3	Escherichia	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0050896,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000				Escherichia	1MUQI@1224,1RNUS@1236,3XN3G@561,COG0114@1,COG0114@2	NA|NA|NA	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate
b1612	199310.c2004	0.0	1116.3	Escherichia	fumA	GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0048037,GO:0050163,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_1778	Escherichia	1MUV9@1224,1RN8U@1236,3XNKC@561,COG1838@1,COG1838@2,COG1951@1,COG1951@2	NA|NA|NA	C	Catalyzes the reversible hydration of fumarate to (S)- malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80 of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso- tartrate. Can also catalyze the isomerization of enol- to keto- oxaloacetate
b1613	316407.1742663	1.6e-221	775.0	Escherichia	manA	GO:0000032,GO:0000271,GO:0003674,GO:0003824,GO:0004476,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006013,GO:0006056,GO:0006057,GO:0006139,GO:0006464,GO:0006486,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009242,GO:0009298,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019309,GO:0019318,GO:0019320,GO:0019438,GO:0019538,GO:0019673,GO:0031506,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0042546,GO:0043170,GO:0043412,GO:0043413,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046483,GO:0055086,GO:0070085,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_696,iECOK1_1307.ECOK1_1731,iECS88_1305.ECS88_1659,iSFV_1184.SFV_1629,iSF_1195.SF1636,iSFxv_1172.SFxv_1833,iS_1188.S1767,iUMN146_1321.UM146_09090,iUTI89_1310.UTI89_C1801	Escherichia	1MUD8@1224,1RQX8@1236,3XN57@561,COG1482@1,COG1482@2	NA|NA|NA	G	mannose-6-phosphate isomerase
b1614	316407.1742664	1.7e-279	968.0	Escherichia	ydgA	GO:0003674,GO:0005488,GO:0005515,GO:0042802											Escherichia	1MYKE@1224,1RRAU@1236,3XM7K@561,COG5339@1,COG5339@2	NA|NA|NA	S	identical protein binding
b1615	316407.85675043	1.6e-246	858.2	Escherichia	uidC	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K16140					ko00000,ko02000	1.B.25.1.5			Escherichia	1MY6H@1224,1RRGX@1236,2DBSC@1,2ZARH@2,3XQPN@561	NA|NA|NA	M	Enhances the activity of the UidB (GusB) glucuronide transporter, on its own however it has no transport activity. Glucuronide transport does not occur in strain K12 due to a variant at position 100 of the UidB (GusB, AC P0CE44, AC P0CE45) protein
b1616	316407.1742670	9.5e-253	879.0	Gammaproteobacteria													Escherichia	1MVUM@1224,1RP5J@1236,COG2211@1,COG2211@2	NA|NA|NA	G	COG2211 Na melibiose symporter and related transporters
b1617	316407.1742671	0.0	1271.5	Escherichia	uidA	GO:0003674,GO:0003824,GO:0004553,GO:0004566,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016054,GO:0016137,GO:0016139,GO:0016787,GO:0016798,GO:0019389,GO:0019391,GO:0019752,GO:0022607,GO:0042802,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000				Escherichia	1MVBN@1224,1RMER@1236,3XQ7T@561,COG3250@1,COG3250@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 2 family
b1618	155864.EDL933_2572	2.2e-102	378.3	Escherichia	uidR	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K16138					ko00000,ko03000				Escherichia	1RARJ@1224,1SXZ7@1236,3XQ9Q@561,COG1309@1,COG1309@2	NA|NA|NA	K	HTH-type transcriptional regulator UidR
b1619	155864.EDL933_2573	2.1e-137	495.0	Escherichia	hdhA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0008206,GO:0008709,GO:0009056,GO:0009987,GO:0016043,GO:0016054,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0030573,GO:0032787,GO:0033764,GO:0042802,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072329,GO:1901360,GO:1901575,GO:1901615	1.1.1.159	ko:K00076	ko00121,map00121				ko00000,ko00001,ko01000				Escherichia	1MUFX@1224,1RSP4@1236,3XPH9@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid
b1620	316407.1742674	4e-187	660.6	Escherichia	malI	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K16136					ko00000,ko03000				Escherichia	1MXUS@1224,1RQFT@1236,3XMGE@561,COG1609@1,COG1609@2	NA|NA|NA	K	Maltose regulon Regulatory protein malI
b1621	316407.1742675	1.7e-298	1031.2	Escherichia	malX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009758,GO:0016020,GO:0044464,GO:0071944	2.7.1.199,2.7.1.208	ko:K02790,ko:K02791	ko00010,ko00500,ko00520,ko02060,map00010,map00500,map00520,map02060	M00266	R02738,R04111	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.3		iECNA114_1301.ECNA114_1668,iECSF_1327.ECSF_1482	Escherichia	1MU2P@1224,1RNF4@1236,3XPA9@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in maltose transport. MalX can also recognize and transport glucose even though this sugar may not represent the natural substrate of the system
b1622	316407.1742676	2.9e-234	817.4	Escherichia	malY	GO:0003674,GO:0003824,GO:0004121,GO:0005488,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016829,GO:0016846,GO:0019219,GO:0019222,GO:0019842,GO:0030170,GO:0031323,GO:0031326,GO:0036094,GO:0043167,GO:0043168,GO:0043433,GO:0044092,GO:0048037,GO:0048519,GO:0050662,GO:0050789,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070279,GO:0080090,GO:0080146,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230		R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007			iEC042_1314.EC042_1790,iECIAI1_1343.ECIAI1_1673,iECO103_1326.ECO103_1762,iECSE_1348.ECSE_1743,iECW_1372.ECW_m1788,iEKO11_1354.EKO11_2154,iEcE24377_1341.EcE24377A_1830,iWFL_1372.ECW_m1788	Escherichia	1MY33@1224,1RP58@1236,3XNTB@561,COG1168@1,COG1168@2	NA|NA|NA	E	maltose regulon
b1623	316407.1742677	6.6e-187	659.8	Escherichia	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009156,GO:0009161,GO:0009163,GO:0009164,GO:0009165,GO:0009167,GO:0009168,GO:0009987,GO:0015949,GO:0015950,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0032261,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340		R01560,R02556	RC00477	ko00000,ko00001,ko01000			iSFV_1184.SFV_1640,iSF_1195.SF1648,iSFxv_1172.SFxv_1849,iS_1188.S1780	Escherichia	1MWBV@1224,1RNVI@1236,3XMUY@561,COG1816@1,COG1816@2	NA|NA|NA	F	Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily
b1624	316407.85675044	1.9e-200	704.9	Escherichia	ydgJ												Escherichia	1MU8F@1224,1RNKY@1236,3XPCD@561,COG0673@1,COG0673@2	NA|NA|NA	S	oxidoreductase activity
b4409	362663.ECP_1569	2e-13	80.5	Escherichia													Escherichia	1QN9M@1224,1TKSR@1236,2C2E0@1,32937@2,3XQ5Q@561	NA|NA|NA		
b1625	155864.EDL933_2580	4e-33	146.7	Escherichia	cnu	GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031554,GO:0043243,GO:0043244,GO:0043900,GO:0043901,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0060566,GO:0065007,GO:0080090,GO:1900190,GO:1900191,GO:1900231,GO:1900232,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141											Escherichia	1MZM3@1224,1S9B1@1236,2CN5N@1,32S5U@2,3XPYY@561	NA|NA|NA	K	Hha and Cnu (YdgT) increase the number of genes bound by H-NS StpA and may also modulate the oligomerization of the H-NS StpA-complex on DNA. The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC
b1626	316407.85675047	1.1e-72	279.3	Escherichia	ydgK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RCYV@1224,1S3X8@1236,29D1G@1,2ZZZI@2,3XPNB@561	NA|NA|NA	S	Protein of unknown function (DUF2569)
b1627	1440052.EAKF1_ch4424c	1.4e-93	349.0	Escherichia	rnfA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03617					ko00000				Escherichia	1MU8X@1224,1RQDN@1236,3XMS7@561,COG4657@1,COG4657@2	NA|NA|NA	C	Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR
b1628	316407.1742687	2.3e-91	341.7	Escherichia	rnfB			ko:K03616					ko00000				Escherichia	1MUWU@1224,1RNSJ@1236,3XPHR@561,COG2878@1,COG2878@2	NA|NA|NA	C	Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR
b1629	316407.1742688	2.8e-302	1044.3	Escherichia	rsxC			ko:K03615					ko00000				Escherichia	1QTUI@1224,1RMIM@1236,3XPF3@561,COG4656@1,COG4656@2	NA|NA|NA	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily
b1630	316407.85675049	3.3e-197	694.1	Escherichia	rnfD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03614					ko00000				Escherichia	1MVY6@1224,1RMEU@1236,3XP8K@561,COG4658@1,COG4658@2	NA|NA|NA	C	Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR
b1631	316407.1742689	5.6e-112	410.2	Escherichia	rnfG	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K03612					ko00000				Escherichia	1RDEP@1224,1RPAD@1236,3XM3D@561,COG4659@1,COG4659@2	NA|NA|NA	C	Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR
b1632	316407.1742690	4.1e-119	434.1	Escherichia	rnfE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03613					ko00000				Escherichia	1MW6N@1224,1RMEH@1236,3XN79@561,COG4660@1,COG4660@2	NA|NA|NA	C	Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR
b1633	199310.c2025	4.1e-118	430.6	Escherichia	nth	GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0003906,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0034644,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0090304,GO:0104004,GO:0140097,GO:1901360	4.2.99.18	ko:K10773	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Escherichia	1MUYQ@1224,1RMHU@1236,3XNCU@561,COG0177@1,COG0177@2	NA|NA|NA	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
b1634	316407.1742700	8.7e-276	955.7	Escherichia	dtpA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0006857,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015333,GO:0015672,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0035442,GO:0035443,GO:0035672,GO:0035673,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042937,GO:0042938,GO:0042939,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904680		ko:K03305					ko00000	2.A.17		iB21_1397.B21_01594,iBWG_1329.BWG_1449,iEC042_1314.EC042_1803,iECBD_1354.ECBD_2009,iECB_1328.ECB_01604,iECDH10B_1368.ECDH10B_1768,iECDH1ME8569_1439.ECDH1ME8569_1578,iECD_1391.ECD_01604,iECUMN_1333.ECUMN_1925,iETEC_1333.ETEC_1669,iEcDH1_1363.EcDH1_2006,iEcSMS35_1347.EcSMS35_1565,iEcolC_1368.EcolC_1995,iJO1366.b1634,iUMNK88_1353.UMNK88_2094,iY75_1357.Y75_RS08570	Escherichia	1MW6W@1224,1RM8P@1236,3XMRM@561,COG3104@1,COG3104@2	NA|NA|NA	U	Proton-dependent permease that transports di- and tripeptides
b1635	155864.EDL933_2591	1.2e-111	409.1	Escherichia	gst	GO:0000302,GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0010035,GO:0016740,GO:0016765,GO:0042221,GO:0042493,GO:0042542,GO:0044424,GO:0044464,GO:0046677,GO:0050896,GO:1901700	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418		R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2			Escherichia	1MY47@1224,1RRI3@1236,3XMJY@561,COG0625@1,COG0625@2	NA|NA|NA	O	Catalyzes the conjugation of reduced glutathione (GSH) to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid. Also possesses thiol disulfide oxidoreductase activity, using GSH to reduce bis-(2-hydroxyethyl) disulfide (HEDS). Has a low level of glutathione-dependent peroxidase activity toward cumene hydroperoxide. Is important for defense against oxidative stress, probably via its peroxidase activity
b1636	316407.1742702	2.2e-162	578.2	Escherichia	pdxY	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008478,GO:0009058,GO:0009108,GO:0009110,GO:0009443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042817,GO:0042819,GO:0042822,GO:0042823,GO:0043094,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.7.1.35	ko:K00868	ko00750,ko01100,map00750,map01100		R00174,R01909,R02493	RC00002,RC00017	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_1723	Escherichia	1MVC9@1224,1RMIE@1236,3XMBR@561,COG2240@1,COG2240@2	NA|NA|NA	H	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
b1637	155864.EDL933_2593	1.6e-246	858.2	Escherichia	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iAF1260.b1637,iBWG_1329.BWG_1452,iECDH10B_1368.ECDH10B_1771,iECDH1ME8569_1439.ECDH1ME8569_1581,iECH74115_1262.ECH74115_2349,iECIAI39_1322.ECIAI39_1418,iECNA114_1301.ECNA114_1685,iECO103_1326.ECO103_1778,iECO111_1330.ECO111_2107,iECO26_1355.ECO26_2366,iECSE_1348.ECSE_1760,iECSF_1327.ECSF_1500,iECSP_1301.ECSP_2202,iECUMN_1333.ECUMN_1928,iECW_1372.ECW_m1805,iECs_1301.ECs2346,iEKO11_1354.EKO11_2137,iETEC_1333.ETEC_1672,iEcDH1_1363.EcDH1_2003,iEcE24377_1341.EcE24377A_1847,iEcHS_1320.EcHS_A1713,iEcSMS35_1347.EcSMS35_1562,iEcolC_1368.EcolC_1992,iJO1366.b1637,iSSON_1240.SSON_1519,iSbBS512_1146.SbBS512_E1829,iUMNK88_1353.UMNK88_2097,iWFL_1372.ECW_m1805,iY75_1357.Y75_RS08585	Escherichia	1MVUQ@1224,1RPKC@1236,3XM5P@561,COG0162@1,COG0162@2	NA|NA|NA	J	to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
b1638	198214.SF1663	6.1e-125	453.4	Gammaproteobacteria													Escherichia	1NZUU@1224,1RMQ2@1236,COG0259@1,COG0259@2	NA|NA|NA	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)
b1639	316407.85675052	2.6e-55	221.1	Escherichia	mliC	GO:0003674,GO:0004857,GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0016020,GO:0019867,GO:0030234,GO:0030312,GO:0030313,GO:0031975,GO:0043086,GO:0044092,GO:0044462,GO:0044464,GO:0050790,GO:0060241,GO:0065007,GO:0065009,GO:0071944,GO:0098772											Escherichia	1N4BY@1224,1S3XI@1236,3XPY3@561,COG3895@1,COG3895@2	NA|NA|NA	S	lysozyme inhibitor activity
b1640	316407.1742706	3.7e-215	753.8	Escherichia	anmK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237	2.7.1.170	ko:K09001					ko00000,ko01000			iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032	Escherichia	1MV4E@1224,1RNTZ@1236,3XNN7@561,COG2377@1,COG2377@2	NA|NA|NA	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
b1641	155864.EDL933_2597	1.2e-53	216.1	Escherichia	slyB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K06077					ko00000				Escherichia	1RA1D@1224,1S202@1236,3XPJ7@561,COG3133@1,COG3133@2	NA|NA|NA	M	Outer membrane lipoprotein slyB
b1642	198214.SF1669	8.8e-72	276.2	Gammaproteobacteria													Escherichia	1N78T@1224,1S26B@1236,COG1846@1,COG1846@2	NA|NA|NA	K	Transcription regulator that can specifically activate or repress expression of target genes
b1643	155864.EDL933_2599	1.5e-36	158.3	Escherichia	ydhI												Escherichia	1NCAP@1224,1SD9Z@1236,2E3ZD@1,32YWB@2,3XQ01@561	NA|NA|NA	S	Protein of unknown function (DUF1656)
b1644	316407.85675055	4e-140	504.2	Escherichia	ydhJ	GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015893,GO:0015906,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0045117,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072348,GO:1901474,GO:1901682,GO:1902599											Escherichia	1MWG0@1224,1RRE3@1236,3XNR4@561,COG1566@1,COG1566@2	NA|NA|NA	V	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
b1645	316407.85675056	0.0	1291.6	Escherichia	ydhK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MX9H@1224,1RMJ4@1236,3XNU5@561,COG1289@1,COG1289@2	NA|NA|NA	S	transmembrane transporter activity
b1646	155864.EDL933_2602	2.7e-91	341.3	Escherichia	sodC	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005507,GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044421,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020				ko00000,ko00001,ko01000			iEcolC_1368.EcolC_1983	Escherichia	1RGV4@1224,1S6KW@1236,3XPCR@561,COG2032@1,COG2032@2	NA|NA|NA	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
b1647	316407.85675058	2.7e-171	607.8	Escherichia	ydhF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MY3G@1224,1RRIC@1236,3XNH4@561,COG4989@1,COG4989@2	NA|NA|NA	S	oxidoreductase activity
b1648	198214.SF1675	8.4e-40	169.1	Gammaproteobacteria													Escherichia	1NGD5@1224,1SCBM@1236,COG3313@1,COG3313@2	NA|NA|NA	S	Fe-S protein
b1649	199310.c2042	1.7e-110	405.2	Escherichia	nemR	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K16137					ko00000,ko03000				Escherichia	1RA4T@1224,1RNQH@1236,3XP6H@561,COG1309@1,COG1309@2	NA|NA|NA	K	Represses the transcription of the nemRA operon by binding to the nemR box
b1650	316407.85675061	1e-209	735.7	Escherichia	nemA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006805,GO:0006807,GO:0008150,GO:0008152,GO:0008748,GO:0009056,GO:0009410,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016628,GO:0016661,GO:0017144,GO:0018937,GO:0018973,GO:0018974,GO:0019326,GO:0019439,GO:0032553,GO:0034567,GO:0036094,GO:0042221,GO:0042537,GO:0043167,GO:0043168,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046256,GO:0046260,GO:0046263,GO:0046857,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071466,GO:0071704,GO:0072490,GO:0072491,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575		ko:K10680	ko00633,ko01120,map00633,map01120		R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000				Escherichia	1MVIX@1224,1RMFI@1236,3XMN8@561,COG1902@1,COG1902@2	NA|NA|NA	C	N-ethylmaleimide reductase activity
b1651	155864.EDL933_2608	8.3e-72	276.2	Escherichia	gloA	GO:0003674,GO:0003824,GO:0004462,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016151,GO:0016829,GO:0016846,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046872,GO:0046914,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615	4.4.1.5	ko:K01759	ko00620,map00620		R02530	RC00004,RC00740	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_733,iECABU_c1320.ECABU_c19040,iECED1_1282.ECED1_1851,iECNA114_1301.ECNA114_1699,iECOK1_1307.ECOK1_1770,iECP_1309.ECP_1597,iECS88_1305.ECS88_1700,iECSF_1327.ECSF_1514,iLF82_1304.LF82_0861,iNRG857_1313.NRG857_08275,iUMN146_1321.UM146_08895,iUTI89_1310.UTI89_C1842,ic_1306.c2044	Escherichia	1RCYX@1224,1S1Z9@1236,3XPJX@561,COG0346@1,COG0346@2	NA|NA|NA	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione
b1652	316407.85675063	3.7e-122	444.1	Escherichia	rnt	GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:1901360		ko:K03683					ko00000,ko01000,ko03016				Escherichia	1MUPK@1224,1RMMH@1236,3XPFQ@561,COG0847@1,COG0847@2	NA|NA|NA	J	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis
b1653	316407.1742726	0.0	2888.6	Escherichia	lhr	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360		ko:K03724					ko00000,ko01000,ko03400				Escherichia	1MUSW@1224,1RSNV@1236,3XQ5E@561,COG1201@1,COG1201@2	NA|NA|NA	L	RNA secondary structure unwinding
b1654	1440052.EAKF1_ch4396	2.8e-60	237.7	Escherichia	grxD	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540		ko:K07390					ko00000,ko03029,ko03110				Escherichia	1MZ4V@1224,1S640@1236,3XPRG@561,COG0278@1,COG0278@2	NA|NA|NA	O	Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters
b1655	316407.85675064	1.2e-109	402.9	Escherichia	ydhO	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009254,GO:0016787,GO:0019538,GO:0030203,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901564		ko:K19303					ko00000,ko01000,ko01002,ko01011				Escherichia	1N0EE@1224,1RP3P@1236,3XN56@561,COG0791@1,COG0791@2	NA|NA|NA	M	A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH. Partially suppresses an mepS disruption mutant
b1656	155864.EDL933_2613	3.8e-110	404.1	Escherichia	sodB	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016				ko00000,ko00001,ko01000			iAF1260.b1656,iAPECO1_1312.APECO1_736,iB21_1397.B21_01616,iBWG_1329.BWG_1471,iE2348C_1286.E2348C_1742,iEC042_1314.EC042_1825,iEC55989_1330.EC55989_1824,iECABU_c1320.ECABU_c19090,iECBD_1354.ECBD_1987,iECB_1328.ECB_01626,iECDH10B_1368.ECDH10B_1790,iECDH1ME8569_1439.ECDH1ME8569_1601,iECD_1391.ECD_01626,iECED1_1282.ECED1_1855,iECH74115_1262.ECH74115_2368,iECIAI1_1343.ECIAI1_1708,iECO103_1326.ECO103_1797,iECO111_1330.ECO111_2126,iECO26_1355.ECO26_2385,iECOK1_1307.ECOK1_1775,iECP_1309.ECP_1601,iECS88_1305.ECS88_1705,iECSE_1348.ECSE_1780,iECSP_1301.ECSP_2222,iECUMN_1333.ECUMN_1946,iECW_1372.ECW_m1823,iECs_1301.ECs2365,iEKO11_1354.EKO11_2118,iETEC_1333.ETEC_1691,iEcDH1_1363.EcDH1_1984,iEcE24377_1341.EcE24377A_1869,iEcHS_1320.EcHS_A1735,iEcSMS35_1347.EcSMS35_1542,iEcolC_1368.EcolC_1973,iG2583_1286.G2583_2051,iJO1366.b1656,iJR904.b1656,iLF82_1304.LF82_2148,iNRG857_1313.NRG857_08300,iSBO_1134.SBO_1475,iSDY_1059.SDY_1882,iSFV_1184.SFV_1678,iSF_1195.SF1684,iSFxv_1172.SFxv_1892,iSSON_1240.SSON_1500,iS_1188.S1816,iSbBS512_1146.SbBS512_E1853,iUMN146_1321.UM146_08870,iUMNK88_1353.UMNK88_2117,iUTI89_1310.UTI89_C1847,iWFL_1372.ECW_m1823,iY75_1357.Y75_RS08680,iZ_1308.Z2678,ic_1306.c2050	Escherichia	1MVW2@1224,1RP7X@1236,3XN20@561,COG0605@1,COG0605@2	NA|NA|NA	C	radicals which are normally produced within the cells and which are toxic to biological systems
b1657	316407.1742730	5e-202	710.3	Escherichia	ydhP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K19577					ko00000,ko02000	2.A.1.2.65			Escherichia	1MU9G@1224,1RM9G@1236,3XM7H@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b1658	155864.EDL933_2616	2.6e-194	684.5	Escherichia	purR	GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002054,GO:0002057,GO:0002060,GO:0003674,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006140,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010563,GO:0010605,GO:0010629,GO:0019219,GO:0019220,GO:0019222,GO:0030808,GO:0030809,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0045936,GO:0045980,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051252,GO:0051253,GO:0060255,GO:0062012,GO:0062014,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03604					ko00000,ko03000				Escherichia	1MVUR@1224,1RN2K@1236,3XNMI@561,COG1609@1,COG1609@2	NA|NA|NA	K	Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression
b1659	155864.EDL933_2617	6.3e-184	649.8	Escherichia	ydhB												Escherichia	1P293@1224,1RPK0@1236,3XMPY@561,COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
b1660	316407.1742733	1.1e-220	772.3	Escherichia	ydhC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1N196@1224,1RPMD@1236,3XMDG@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b1661	199310.c2055	4.5e-232	810.1	Escherichia	cfa	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0008825,GO:0009987,GO:0016740,GO:0016741,GO:0030258,GO:0032259,GO:0044237,GO:0044238,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704	2.1.1.79	ko:K00574					ko00000,ko01000			iEC55989_1330.EC55989_1829,iECIAI1_1343.ECIAI1_1713,iECO103_1326.ECO103_1803,iECSE_1348.ECSE_1785,iEcE24377_1341.EcE24377A_1875	Escherichia	1MX3U@1224,1RNID@1236,3XMDR@561,COG2230@1,COG2230@2	NA|NA|NA	M	Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge
b1662	198214.SF1690	1.9e-118	431.8	Gammaproteobacteria													Escherichia	1MUMB@1224,1RMSY@1236,COG0307@1,COG0307@2	NA|NA|NA	H	Riboflavin synthase
b1663	316407.1742737	4.1e-248	863.6	Escherichia	mdtK	GO:0000302,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0006857,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0015238,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0033554,GO:0034599,GO:0034614,GO:0035442,GO:0035672,GO:0035673,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042938,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:1901700,GO:1901701,GO:1904680		ko:K03327					ko00000,ko02000	2.A.66.1			Escherichia	1MUAM@1224,1RP5M@1236,3XMVX@561,COG0534@1,COG0534@2	NA|NA|NA	P	Multidrug efflux pump that functions probably as a Na( ) drug antiporter
b1664	316407.1742738	4.4e-148	531.2	Escherichia	ydhQ	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1NQVP@1224,1SMRB@1236,3XNU0@561,COG3468@1,COG3468@2	NA|NA|NA	MU	cellular response to DNA damage stimulus
b1667	198214.SF1695	4.6e-51	206.8	Gammaproteobacteria													Escherichia	1MZC2@1224,1S98Z@1236,2C948@1,32SAI@2	NA|NA|NA	S	monooxygenase
b1668	316407.85675067	2.2e-311	1074.7	Escherichia	ydhS												Escherichia	1N8CF@1224,1RS86@1236,3XP0H@561,COG4529@1,COG4529@2	NA|NA|NA	S	FAD-NAD(P)-binding
b1669	316407.1742749	5e-68	264.6	Escherichia	ydhT												Escherichia	1R6VT@1224,1S0US@1236,2DBJN@1,2Z9MR@2,3XQ4K@561	NA|NA|NA		
b1670	316407.1742750	1.5e-149	535.4	Escherichia	ydhU	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08354	ko00920,ko01120,map00920,map01120		R10149	RC02823	ko00000,ko00001,ko02000	5.A.3.5			Escherichia	1R4HB@1224,1RSIU@1236,3XQV0@561,COG4117@1,COG4117@2	NA|NA|NA	C	respiratory electron transport chain
b1671	316407.85675068	4.8e-133	480.3	Escherichia	ydhX	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464											Escherichia	1R5IV@1224,1RR1Z@1236,3XQ9N@561,COG0437@1,COG0437@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
b1672	316407.85675069	2.1e-117	428.3	Escherichia	ydhW												Escherichia	1RBE4@1224,1S3H4@1236,28VFF@1,2ZHI0@2,3XQRK@561	NA|NA|NA		
b1673	316407.85675070	0.0	1468.8	Escherichia	ydhV												Escherichia	1MWBB@1224,1RSCT@1236,3XQTC@561,COG2414@1,COG2414@2	NA|NA|NA	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
b1674	155864.EDL933_2630	1.6e-111	408.7	Escherichia	ydhY												Escherichia	1MUIE@1224,1RZEF@1236,3XQFQ@561,COG0437@1,COG0437@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
b1675	198214.SF1703	2e-29	134.4	Gammaproteobacteria													Escherichia	1N1HX@1224,1SDWM@1236,2D4UA@1,32THM@2	NA|NA|NA	S	fumarate hydratase activity
b1676	155864.EDL933_2633	2.8e-260	904.0	Escherichia	pykF	GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147			iECO103_1326.ECO103_1819	Escherichia	1MU21@1224,1RMW3@1236,3XMTB@561,COG0469@1,COG0469@2	NA|NA|NA	F	Pyruvate kinase
b1677	1440052.EAKF1_ch4375c	8.3e-16	89.4	Escherichia	lpp	GO:0003674,GO:0005488,GO:0005515,GO:0005539,GO:0005575,GO:0005623,GO:0006629,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0009987,GO:0016020,GO:0016021,GO:0019867,GO:0030258,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0042802,GO:0042834,GO:0044237,GO:0044238,GO:0044255,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0071704,GO:0071944,GO:0097367		ko:K06078					ko00000,ko01011				Escherichia	1MZCW@1224,1S8YB@1236,3XQ0U@561,COG4238@1,COG4238@2	NA|NA|NA	M	Lipoprotein leucine-zipper
b1678	316407.85675073	1.7e-187	661.8	Escherichia	ynhG	GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0019538,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0070004,GO:0070008,GO:0070011,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901564		ko:K19234					ko00000,ko01002,ko01011				Escherichia	1MVYT@1224,1RMNC@1236,3XN0W@561,COG1376@1,COG1376@2	NA|NA|NA	M	cysteine-type carboxypeptidase activity
b1679	316407.85675074	1.9e-71	275.0	Escherichia	sufE	GO:0003674,GO:0006464,GO:0006790,GO:0006807,GO:0006950,GO:0006979,GO:0008047,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0019538,GO:0022607,GO:0030234,GO:0031162,GO:0031163,GO:0036211,GO:0043085,GO:0043170,GO:0043412,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071704,GO:0071840,GO:0097163,GO:0098772,GO:0140104,GO:1901564		ko:K02426					ko00000			iSBO_1134.SBO_1451,iSFV_1184.SFV_1702,iSF_1195.SF1708,iSFxv_1172.SFxv_1916,iS_1188.S1841,iSbBS512_1146.SbBS512_E1880	Escherichia	1RI8F@1224,1S65C@1236,3XPKR@561,COG2166@1,COG2166@2	NA|NA|NA	S	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process
b1680	316407.1742766	2.7e-235	820.8	Escherichia	sufS	GO:0001887,GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009000,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0019538,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031162,GO:0031163,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100		R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_757,iEC55989_1330.EC55989_1847,iECED1_1282.ECED1_1879,iECO111_1330.ECO111_2149,iECO26_1355.ECO26_2408,iECOK1_1307.ECOK1_1800,iECS88_1305.ECS88_1730,iECW_1372.ECW_m1847,iEKO11_1354.EKO11_2095,iUMN146_1321.UM146_08755,iUTI89_1310.UTI89_C1872,iWFL_1372.ECW_m1847	Escherichia	1MUPD@1224,1RNIY@1236,3XMA9@561,COG0520@1,COG0520@2	NA|NA|NA	H	Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo
b1681	316407.1742765	5.3e-242	843.2	Escherichia	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840		ko:K09015					ko00000			iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	Escherichia	1MVK0@1224,1RP2A@1236,3XM2Q@561,COG0719@1,COG0719@2	NA|NA|NA	O	The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. Required for the stability of the FhuF protein
b1682	316407.1742764	6.1e-137	493.4	Escherichia	sufC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840		ko:K09013					ko00000,ko02000			iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710	Escherichia	1MUGK@1224,1RPFE@1236,3XNS8@561,COG0396@1,COG0396@2	NA|NA|NA	P	Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation
b1683	316407.85675075	1.3e-292	1011.5	Escherichia	sufB	GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840		ko:K09014					ko00000			iECH74115_1262.ECH74115_2397,iECSP_1301.ECSP_2250	Escherichia	1MVKY@1224,1RQ65@1236,3XND6@561,COG0719@1,COG0719@2	NA|NA|NA	O	The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation
b1684	316407.1742762	8.6e-68	262.7	Escherichia	sufA	GO:0003674,GO:0005488,GO:0005506,GO:0006790,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046872,GO:0046914,GO:0048037,GO:0050896,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:1901564		ko:K05997					ko00000				Escherichia	1RH6T@1224,1S5XD@1236,3XPKS@561,COG0316@1,COG0316@2	NA|NA|NA	S	Belongs to the HesB IscA family
b1685	198214.SF1715	9.2e-26	122.1	Gammaproteobacteria													Escherichia	1N8X4@1224,1SCDQ@1236,2E58W@1,3301A@2	NA|NA|NA	S	Domain of unknown function
b1686	316407.1742761	2.6e-73	281.2	Escherichia	menI	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0061522,GO:0071704,GO:1901576,GO:1901661,GO:1901663	3.1.2.28	ko:K19222	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07262	RC00004,RC00174	ko00000,ko00001,ko00002,ko01000				Escherichia	1RGVP@1224,1S5WY@1236,3XPMU@561,COG2050@1,COG2050@2	NA|NA|NA	Q	Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA)
b1687	316407.1742760	0.0	2055.4	Escherichia	ydiJ	GO:0000166,GO:0003674,GO:0005488,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0097159,GO:1901265,GO:1901363											Escherichia	1MU6Y@1224,1RQX2@1236,3XM9Z@561,COG0247@1,COG0247@2,COG0277@1,COG0277@2	NA|NA|NA	C	flavin adenine dinucleotide binding
b1688	198214.SF1718	3.3e-195	687.6	Gammaproteobacteria													Escherichia	1MVX7@1224,1RNN1@1236,COG0628@1,COG0628@2	NA|NA|NA	S	ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated
b1689	316407.85675077	1.1e-64	252.3	Escherichia	ydiL												Escherichia	1MYSY@1224,1S6TE@1236,2C13B@1,32R81@2,3XQZG@561	NA|NA|NA	S	DNA binding
b1690	316407.85675078	2e-222	778.1	Escherichia	ydiM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1PMZX@1224,1RZE0@1236,3XNRY@561,COG0738@1,COG0738@2	NA|NA|NA	P	transporter activity
b1691	316407.85675079	4.8e-227	793.5	Escherichia	ydiN	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015291,GO:0015292,GO:0016020,GO:0022804,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944											Escherichia	1QYXI@1224,1T3WS@1236,3XRNF@561,COG2271@1,COG2271@2	NA|NA|NA	G	uniporter activity
b1692	199310.c2087	1.5e-163	582.0	Escherichia	ydiB	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0030266,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0052734,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.282	ko:K05887	ko00400,ko01100,ko01110,ko01130,map00400,map01100,map01110,map01130		R01872,R02413,R06846,R06847	RC00154,RC00206	ko00000,ko00001,ko01000			iSFxv_1172.SFxv_1929,iS_1188.S1854	Escherichia	1MVH4@1224,1RS73@1236,3XNUP@561,COG0169@1,COG0169@2	NA|NA|NA	E	The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD
b1693	316407.1742757	3e-131	474.6	Escherichia	aroD	GO:0003674,GO:0003824,GO:0003855,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009058,GO:0009712,GO:0009713,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018958,GO:0019438,GO:0019752,GO:0032787,GO:0042537,GO:0042802,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046189,GO:0046278,GO:0046279,GO:0046394,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_1860	Escherichia	1NG0G@1224,1S7CZ@1236,3XRGF@561,COG0710@1,COG0710@2	NA|NA|NA	E	Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate
b1694	316407.85675080	1e-306	1058.5	Escherichia	ydiF	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008410,GO:0008775,GO:0009987,GO:0016043,GO:0016740,GO:0016782,GO:0019752,GO:0022607,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840	2.8.3.8	ko:K19709	ko00627,ko00640,ko00650,ko01100,ko01120,map00627,map00640,map00650,map01100,map01120		R01179,R01359,R07832	RC00012,RC00014	ko00000,ko00001,ko01000				Escherichia	1MUJW@1224,1RP80@1236,3XM2K@561,COG4670@1,COG4670@2	NA|NA|NA	I	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons
b1695	155864.EDL933_2652	4.2e-222	776.9	Escherichia	ydiO	GO:0003674,GO:0003824,GO:0006066,GO:0008150,GO:0008152,GO:0009058,GO:0016491,GO:0016627,GO:0034308,GO:0034309,GO:0044281,GO:0044283,GO:0046165,GO:0052890,GO:0055114,GO:0071270,GO:0071271,GO:0071704,GO:1901576,GO:1901615,GO:1901617											Escherichia	1MUDR@1224,1RMMJ@1236,3XP3K@561,COG1960@1,COG1960@2	NA|NA|NA	I	Acyl-coa dehydrogenase
b1696	316407.1742775	2.1e-176	624.8	Escherichia	ydiP	GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Escherichia	1MXC6@1224,1RZKV@1236,3XNJU@561,COG1917@1,COG1917@2,COG2207@1,COG2207@2	NA|NA|NA	K	Transcriptional regulator
b1697	316407.85675082	3.4e-135	487.6	Escherichia	ydiQ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0033554,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114											Escherichia	1MVH6@1224,1RZU6@1236,3XPHD@561,COG2086@1,COG2086@2	NA|NA|NA	C	Electron transfer flavoprotein
b1698	316407.1742777	2.1e-174	618.2	Escherichia	ydiR	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575											Escherichia	1MUFI@1224,1RMK7@1236,3XM9A@561,COG2025@1,COG2025@2	NA|NA|NA	C	Electron transfer flavoprotein
b1699	316407.1742778	2.7e-241	840.9	Escherichia	ydiS			ko:K00313					ko00000,ko01000				Escherichia	1MVU6@1224,1RNY5@1236,3XNRE@561,COG0644@1,COG0644@2	NA|NA|NA	C	electron transfer flavoprotein-quinone oxidoreductase ydiS
b1700	316407.1742779	3.3e-54	217.2	Escherichia	ydiT												Escherichia	1RHTX@1224,1S6ZD@1236,3XPQH@561,COG2440@1,COG2440@2	NA|NA|NA	C	Could be a 3Fe-4S cluster-containing protein
b1701	316407.85675083	0.0	1149.8	Escherichia	fadK	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0015645,GO:0016020,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0031956,GO:0044464,GO:0071944		ko:K12507					ko00000,ko01000,ko01004			iECIAI1_1343.ECIAI1_1755	Escherichia	1MU6G@1224,1RMQ4@1236,3XMA2@561,COG0318@1,COG0318@2	NA|NA|NA	IQ	Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Is maximally active on C6 0, C8 0 and C12 0 fatty acids, while has a low activity on C14-C18 chain length fatty acids. Is involved in the anaerobic beta-oxidative degradation of fatty acids, which allows anaerobic growth of E.coli on fatty acids as a sole carbon and energy source in the presence of nitrate or fumarate as a terminal electron acceptor. Can functionally replace FadD under anaerobic conditions
b1702	316407.1742783	0.0	1575.5	Escherichia	ppsA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000			iEcE24377_1341.EcE24377A_1919	Escherichia	1MU0R@1224,1RP3T@1236,3XMCT@561,COG0574@1,COG0574@2,COG1080@1,COG1080@2	NA|NA|NA	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
b1703	155864.EDL933_2662	1.4e-153	548.9	Escherichia	ppsR	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030234,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0098772	2.7.11.33,2.7.4.28	ko:K09773					ko00000,ko01000				Escherichia	1MUHU@1224,1RPHX@1236,3XN7K@561,COG1806@1,COG1806@2	NA|NA|NA	F	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation
b1704	316407.1742785	5.8e-202	709.9	Escherichia	aroH	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000			iSbBS512_1146.SbBS512_E1908	Escherichia	1MU5Q@1224,1RMAA@1236,3XMMD@561,COG0722@1,COG0722@2	NA|NA|NA	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
b1705	155864.EDL933_2664	7.6e-28	129.0	Bacteria													Escherichia	COG4256@1,COG4256@2	NA|NA|NA	P	Hemin uptake protein
b1706	316407.1742787	6e-282	976.1	Escherichia	ydiU			ko:K08997					ko00000				Escherichia	1MVK3@1224,1RNCS@1236,3XMWI@561,COG0397@1,COG0397@2	NA|NA|NA	S	Belongs to the UPF0061 (SELO) family
b1707	316407.85675085	7.1e-135	486.5	Escherichia	ydiV	GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008134,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0040012,GO:0040013,GO:0043392,GO:0043433,GO:0044092,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051090,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051252,GO:0051270,GO:0051271,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:1902021,GO:1902201,GO:1903506,GO:2000112,GO:2000145,GO:2000146,GO:2000677,GO:2000678,GO:2001141											Escherichia	1RAZ1@1224,1S1MP@1236,3XPNQ@561,COG2200@1,COG2200@2	NA|NA|NA	K	Upon overexpression acts as a novel anti-FlhC(2)FlhD(4) factor, decreasing its DNA-binding activity, able to negatively regulate expression of flagellar class II operons including FliC
b1708	316407.1742788	1.8e-86	325.1	Escherichia	nlpC			ko:K13695					ko00000,ko01002				Escherichia	1N0EE@1224,1RR2X@1236,3XMZY@561,COG0791@1,COG0791@2	NA|NA|NA	M	cysteine-type peptidase activity
b1709	316407.1742789	2.3e-136	491.5	Escherichia	btuD	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008144,GO:0008150,GO:0015238,GO:0015399,GO:0015405,GO:0015420,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019898,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035461,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.33	ko:K06074	ko02010,map02010	M00241			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.13		iEC042_1314.EC042_1876,iEC55989_1330.EC55989_1877,iECIAI1_1343.ECIAI1_1765,iECIAI39_1322.ECIAI39_1344,iECSE_1348.ECSE_1834,iECUMN_1333.ECUMN_2000,iECW_1372.ECW_m1878,iEKO11_1354.EKO11_2066,iETEC_1333.ETEC_1742,iEcE24377_1341.EcE24377A_1928,iEcHS_1320.EcHS_A1789,iEcSMS35_1347.EcSMS35_1481,iEcolC_1368.EcolC_1922,iSDY_1059.SDY_1804,iSFV_1184.SFV_1514,iSF_1195.SF1522,iSFxv_1172.SFxv_1705,iSSON_1240.SSON_1449,iS_1188.S1639,iUMNK88_1353.UMNK88_2172,iWFL_1372.ECW_m1878	Escherichia	1NXS9@1224,1RRMD@1236,3XNE2@561,COG4138@1,COG4138@2	NA|NA|NA	P	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
b1710	316407.1742790	1.9e-103	381.7	Escherichia	btuE	GO:0003674,GO:0003824,GO:0004601,GO:0004602,GO:0005575,GO:0005623,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0042597,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918		R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_1795,iEC55989_1330.EC55989_1878,iECABU_c1320.ECABU_c19650,iEcHS_1320.EcHS_A1790,iLF82_1304.LF82_0251,iNRG857_1313.NRG857_08570,iSFV_1184.SFV_1513,ic_1306.c2106	Escherichia	1RD1R@1224,1RR4X@1236,3XRK7@561,COG0386@1,COG0386@2	NA|NA|NA	O	Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent. In vitro, utilizes preferentially thioredoxin A to decompose hydrogen peroxide as well as cumene-, tert-butyl-, and linoleic acid hydroperoxides, suggesting that it may have one or more organic hydroperoxide as its physiological substrate
b1711	316407.1742791	1.1e-175	622.5	Escherichia	btuC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0042221,GO:0042493,GO:0042802,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K06073	ko02010,map02010	M00241			ko00000,ko00001,ko00002,ko02000	3.A.1.13		iECO103_1326.ECO103_1855,iECO111_1330.ECO111_2181,iECO26_1355.ECO26_2440,iECW_1372.ECW_m1880,iEKO11_1354.EKO11_2064,iEcHS_1320.EcHS_A1791,iEcolC_1368.EcolC_1920,iWFL_1372.ECW_m1880	Escherichia	1R34H@1224,1RR7W@1236,3XNA9@561,COG4139@1,COG4139@2	NA|NA|NA	U	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane
b1712	1006004.GBAG_1585	1.4e-47	195.3	Gammaproteobacteria													Escherichia	1RH5Z@1224,1S61Z@1236,COG0776@1,COG0776@2	NA|NA|NA	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
b1713	316407.1742793	0.0	1586.6	Escherichia	pheT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iG2583_1286.G2583_2160	Escherichia	1MWKS@1224,1RMIH@1236,3XMDP@561,COG0072@1,COG0072@2,COG0073@1,COG0073@2	NA|NA|NA	J	phenylalanine-tRNA ligase activity
b1714	316407.85675086	4.2e-186	657.1	Escherichia	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iSSON_1240.SSON_1444	Escherichia	1MVD7@1224,1RN22@1236,3XNIZ@561,COG0016@1,COG0016@2	NA|NA|NA	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
b1716	1006000.GKAS_03624	5.2e-54	216.9	Gammaproteobacteria													Escherichia	1RGU2@1224,1S3P3@1236,COG0292@1,COG0292@2	NA|NA|NA	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
b1717	1005994.GTGU_00408	1.6e-28	131.3	Gammaproteobacteria													Escherichia	1N6V4@1224,1SCHI@1236,COG0291@1,COG0291@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL35 family
b1718	316407.1742797	2.1e-91	341.7	Escherichia	infC	GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767		ko:K02520					ko00000,ko03012,ko03029				Escherichia	1RDD2@1224,1S4E6@1236,3XMQM@561,COG0290@1,COG0290@2	NA|NA|NA	J	binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
b1719	198214.SF1512	0.0	1333.9	Gammaproteobacteria													Escherichia	1MUP2@1224,1RMYE@1236,COG0441@1,COG0441@2	NA|NA|NA	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
b4494	155864.EDL933_2679	3.5e-74	286.2	Gammaproteobacteria													Escherichia	1QWC1@1224,1T2TD@1236,32YAJ@2,COG0666@1	NA|NA|NA	S	Corresponds to locus_tag
b4535	155864.EDL933_2680	5.6e-12	75.5	Escherichia													Escherichia	1NH6A@1224,1SH66@1236,2DSBC@1,33FD2@2,3XQ5X@561	NA|NA|NA		
b1722	316407.85675090	6.4e-142	510.0	Escherichia	ydiY			ko:K07283					ko00000				Escherichia	1MWI4@1224,1RN4J@1236,3XP5N@561,COG3137@1,COG3137@2	NA|NA|NA	M	Protein of unknown function, DUF481
b1723	316407.85675091	1.6e-166	592.0	Escherichia	pfkB	GO:0000287,GO:0003674,GO:0003824,GO:0003872,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008443,GO:0009024,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046872,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0061615,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.11	ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_793,iUTI89_1310.UTI89_C1916	Escherichia	1MVNW@1224,1RS3Y@1236,3XPFP@561,COG1105@1,COG1105@2	NA|NA|NA	F	Belongs to the carbohydrate kinase PfkB family
b1724	155864.EDL933_2683	1.5e-46	191.8	Escherichia	ydiZ	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1N13Q@1224,1S9QK@1236,2CY9P@1,32T3T@2,3XPVV@561	NA|NA|NA	S	endoribonuclease activity
b1725	316407.1742814	3.3e-171	607.4	Escherichia	yniA	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237											Escherichia	1MVHX@1224,1RRC5@1236,3XP3H@561,COG3001@1,COG3001@2	NA|NA|NA	G	kinase activity
b1726	316407.85675093	8.6e-93	346.3	Escherichia	yniB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1QISB@1224,1RP93@1236,28IJC@1,2Z8K9@2,3XNS4@561	NA|NA|NA	S	YniB-like protein
b1727	316407.1742822	1e-119	436.0	Escherichia	yniC	GO:0000287,GO:0003674,GO:0003824,GO:0003850,GO:0004346,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050084,GO:0050286,GO:0050308,GO:0050309	3.1.3.23	ko:K19270					ko00000,ko01000				Escherichia	1NF90@1224,1RNP8@1236,3XMXW@561,COG0637@1,COG0637@2	NA|NA|NA	S	this is a biologically important activity in vivo since it contributes to the elimination of this toxic compound and plays an important role in the resistance of E.coli to 2-deoxyglucose
b1728	198214.SF1502	4.4e-114	417.2	Gammaproteobacteria													Escherichia	1Q0WR@1224,1RU1K@1236,COG1988@1,COG1988@2	NA|NA|NA	S	membrane-bound metal-dependent
b1729	316407.1742823	1.3e-244	852.0	Escherichia	ydjN	GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006791,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015184,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015811,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:0098656,GO:1901682,GO:1902475,GO:1903825,GO:1905039		ko:K06956					ko00000				Escherichia	1R3F8@1224,1RMHV@1236,3XNSQ@561,COG1823@1,COG1823@2	NA|NA|NA	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family
b1730	316407.85675095	1.4e-147	528.9	Escherichia	ydjO												Escherichia	1NR3K@1224,1SMQV@1236,2EW0H@1,33PDX@2,3XR75@561	NA|NA|NA		
b1731	155864.EDL933_2690	1.2e-38	165.2	Escherichia	cedA	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0008150,GO:0050789,GO:0050794,GO:0051302,GO:0065007,GO:0097159,GO:1901363		ko:K15722					ko00000				Escherichia	1N1CP@1224,1S8XC@1236,2CFPH@1,32S26@2,3XPYW@561	NA|NA|NA	D	Activates the cell division inhibited by chromosomal DNA over-replication
b1732	316407.1742829	0.0	1511.9	Escherichia	katE	GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0042221,GO:0042737,GO:0042743,GO:0042744,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070887,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1990748	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000			iECO26_1355.ECO26_2506	Escherichia	1MUXZ@1224,1RNE7@1236,3XM73@561,COG0753@1,COG0753@2	NA|NA|NA	P	serves to protect cells from the toxic effects of hydrogen peroxide
b1733	316407.1742830	1.2e-140	505.8	Escherichia	chbG	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009056,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0036311,GO:0052777,GO:0052778,GO:0052779,GO:0052782,GO:0071704,GO:1901135,GO:1901136,GO:1901575	3.5.1.105	ko:K03478					ko00000,ko01000				Escherichia	1MX3P@1224,1RRC4@1236,3XPHH@561,COG3394@1,COG3394@2	NA|NA|NA	G	Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho- beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF
b1734	316407.1742831	5.3e-264	916.4	Escherichia	chbF	GO:0003674,GO:0003824,GO:0004553,GO:0005488,GO:0005515,GO:0008422,GO:0008706,GO:0015926,GO:0016787,GO:0016798,GO:0042802	3.2.1.86	ko:K01222	ko00010,ko00500,map00010,map00500		R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000		GT4	iECH74115_1262.ECH74115_2452,iECSP_1301.ECSP_2302	Escherichia	1NI6G@1224,1RPG8@1236,3XP95@561,COG1486@1,COG1486@2	NA|NA|NA	G	methyl beta-D-glucoside 6-phosphate glucohydrolase activity
b1735	316407.1742832	2.3e-156	558.1	Escherichia	celD	GO:0001047,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03490					ko00000,ko03000				Escherichia	1MXV1@1224,1RQRD@1236,3XMCY@561,COG1917@1,COG1917@2,COG2169@1,COG2169@2	NA|NA|NA	K	Dual-function repressor activator of the chbBCARFG operon. In the absence of the inducing sugar chitobiose, together with NagC, represses the chbBCARFG operon for the uptake and metabolism of chitobiose. In association with Crp, and probably in the presence of chitobiose 6-phosphate, induces the transcription of the chbBCARFG operon
b1736	198214.SF1490	1.9e-53	214.9	Gammaproteobacteria													Escherichia	1RI0T@1224,1S75F@1236,COG1447@1,COG1447@2	NA|NA|NA	G	Phosphotransferase System
b1737	316407.85675097	1e-227	795.8	Escherichia	chbC	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264,GO:1902815		ko:K02761	ko00500,ko02060,map00500,map02060	M00275	R11170,R11172	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.3.2		iECABU_c1320.ECABU_c19930	Escherichia	1PF2A@1224,1SYHD@1236,3XMPB@561,COG1455@1,COG1455@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
b1738	1440052.EAKF1_ch4313	3.1e-50	204.1	Escherichia	chbB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044424,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0090563,GO:0090566,GO:1901264,GO:1902815	2.7.1.196,2.7.1.205	ko:K02760	ko00500,ko02060,map00500,map02060	M00275	R11170,R11172	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.3.2		iSbBS512_1146.SbBS512_E1982	Escherichia	1RITP@1224,1S632@1236,3XR15@561,COG1440@1,COG1440@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2)
b1739	155864.EDL933_2698	8.2e-57	226.1	Escherichia	osmE	GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0050896		ko:K04064					ko00000				Escherichia	1RD8V@1224,1S48R@1236,3XPRB@561,COG2913@1,COG2913@2	NA|NA|NA	M	response to osmotic stress
b1740	316407.1742846	1.4e-153	548.9	Escherichia	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0033554,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000			iECSE_1348.ECSE_1910,iECW_1372.ECW_m1909,iEKO11_1354.EKO11_2035,iETEC_1333.ETEC_1772,iEcE24377_1341.EcE24377A_1961,iSSON_1240.SSON_1418,iWFL_1372.ECW_m1909	Escherichia	1MU9U@1224,1RNKA@1236,3XM8K@561,COG0171@1,COG0171@2	NA|NA|NA	F	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source
b1741	316407.85675098	1.7e-170	605.1	Escherichia	cho	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0031668,GO:0032991,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391		ko:K05984					ko00000,ko01000,ko03400				Escherichia	1QU1K@1224,1RMJM@1236,3XNBR@561,COG0322@1,COG0322@2	NA|NA|NA	L	When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair
b1742	316407.1742847	4.1e-109	400.6	Escherichia	ves			ko:K09975					ko00000				Escherichia	1MXSD@1224,1RMHD@1236,3XP6F@561,COG3758@1,COG3758@2	NA|NA|NA	S	Belongs to the Ves family
b1743	316407.1742848	5.2e-81	307.0	Escherichia	spy	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0010033,GO:0014070,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0050896,GO:0051082,GO:0061077,GO:1990507											Escherichia	1RBDH@1224,1S2DT@1236,3XPA1@561,COG3678@1,COG3678@2	NA|NA|NA	NPTU	An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region
b1744	316407.85675099	1.6e-190	671.8	Escherichia	astE	GO:0003674,GO:0003824,GO:0009017,GO:0016787,GO:0016810,GO:0016811	3.5.1.96	ko:K05526	ko00330,ko01100,map00330,map01100		R00411	RC00064,RC00090	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_813,iECABU_c1320.ECABU_c20010,iECED1_1282.ECED1_1946,iECOK1_1307.ECOK1_1864,iECS88_1305.ECS88_1796,iUMN146_1321.UM146_08430,iUTI89_1310.UTI89_C1939,ic_1306.c2144	Escherichia	1MW1T@1224,1RQPG@1236,3XNVD@561,COG2988@1,COG2988@2	NA|NA|NA	E	Belongs to the AspA AstE family. Succinylglutamate desuccinylase subfamily
b1745	316407.85675100	7.6e-247	859.4	Escherichia	astB	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008150,GO:0008152,GO:0009015,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.3.23	ko:K01484	ko00330,ko01100,map00330,map01100		R04189	RC00024	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_2463,iECSP_1301.ECSP_2313,iECs_1301.ECs2451,iG2583_1286.G2583_2191	Escherichia	1MUJV@1224,1RNSS@1236,3XMGR@561,COG3724@1,COG3724@2	NA|NA|NA	E	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2)
b1746	316407.85675101	2.2e-287	994.2	Escherichia	astD	GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.71	ko:K06447	ko00330,ko01100,map00330,map01100		R05049	RC00080	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c20030,iEcHS_1320.EcHS_A1829,ic_1306.c2146	Escherichia	1MV2I@1224,1RPQW@1236,3XMV0@561,COG1012@1,COG1012@2	NA|NA|NA	C	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate
b1747	155864.EDL933_2706	1.8e-200	704.9	Escherichia	astA		2.3.1.109	ko:K00673	ko00330,ko01100,map00330,map01100		R00832	RC00004,RC00064	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_1875	Escherichia	1MWHC@1224,1RMXG@1236,3XMJ6@561,COG3138@1,COG3138@2	NA|NA|NA	E	Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine
b1748	316407.1742857	3.8e-237	827.0	Escherichia	astC	GO:0003674,GO:0003824,GO:0003992,GO:0005488,GO:0005515,GO:0006082,GO:0006105,GO:0006520,GO:0006525,GO:0006526,GO:0006527,GO:0006591,GO:0006593,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0019545,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042450,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043825,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.6.1.81	ko:K00840	ko00330,ko01100,map00330,map01100		R04217	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007			iAPECO1_1312.APECO1_817,iEC55989_1330.EC55989_1916,iECABU_c1320.ECABU_c20050,iECED1_1282.ECED1_1950,iECOK1_1307.ECOK1_1868,iECP_1309.ECP_1694,iECS88_1305.ECS88_1800,iEcSMS35_1347.EcSMS35_1443,iUMN146_1321.UM146_08405,iUTI89_1310.UTI89_C1943,ic_1306.c2148	Escherichia	1MV3C@1224,1RMV1@1236,3XNAC@561,COG4992@1,COG4992@2	NA|NA|NA	E	Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase
b1749	316407.1742858	7.2e-160	569.7	Escherichia	xthA	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008853,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.2	ko:K01142	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Escherichia	1MVII@1224,1RN4H@1236,3XPFE@561,COG0708@1,COG0708@2	NA|NA|NA	L	Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities
b1750	316407.1742859	3.1e-122	444.5	Escherichia	ydjX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MVF3@1224,1RSK1@1236,3XMYD@561,COG0398@1,COG0398@2	NA|NA|NA	S	SNARE associated Golgi protein
b1751	316407.85675103	7.5e-126	456.4	Escherichia	ydjY	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1NZYD@1224,1S1F4@1236,28JAM@1,2Z95F@2,3XNDZ@561	NA|NA|NA		
b1752	316407.85675104	1.2e-123	449.1	Escherichia	ydjZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RDZ2@1224,1RYPP@1236,3XPQ3@561,COG0398@1,COG0398@2	NA|NA|NA	S	SNARE associated Golgi protein
b1753	316407.85675105	2.8e-99	367.9	Escherichia	ynjA												Escherichia	1RC52@1224,1S2A0@1236,3XQ7H@561,COG2128@1,COG2128@2	NA|NA|NA	S	peroxiredoxin activity
b1754	316407.85675106	1.1e-230	805.4	Escherichia	ynjB			ko:K05777		M00192			ko00000,ko00002,ko02000				Escherichia	1MWJ7@1224,1RQ0I@1236,3XNDY@561,COG4134@1,COG4134@2	NA|NA|NA	S	Bacterial extracellular solute-binding protein
b1755	511145.b1755	4.9e-282	976.5	Escherichia	ynjC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K05778		M00192			ko00000,ko00002,ko02000				Escherichia	1MV6R@1224,1RR4B@1236,3XNN0@561,COG4135@1,COG4135@2	NA|NA|NA	P	ABC transporter permease
b1756	316407.85675108	1.2e-117	429.1	Escherichia	ynjD			ko:K05779		M00192			ko00000,ko00002,ko02000				Escherichia	1RA88@1224,1S207@1236,3XNBV@561,COG4136@1,COG4136@2	NA|NA|NA	P	ABC transporter, ATP-binding protein
b1757	316407.85675109	7.6e-260	902.5	Escherichia	ynjE	GO:0003674,GO:0003824,GO:0016740,GO:0016782,GO:0016783	2.8.1.11	ko:K21028	ko04122,map04122		R07461		ko00000,ko00001,ko01000				Escherichia	1MW4B@1224,1RQX7@1236,3XPET@561,COG2897@1,COG2897@2	NA|NA|NA	M	thiosulfate sulfurtransferase activity
b1758	316407.85675110	1.4e-107	395.6	Escherichia	ynjF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RD5Y@1224,1RZ4Q@1236,3XNG1@561,COG0558@1,COG0558@2	NA|NA|NA	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
b1759	316407.1742868	5.9e-70	270.0	Escherichia	nudG	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.6.1.65	ko:K08320					ko00000,ko01000			iE2348C_1286.E2348C_1887,iECP_1309.ECP_1705,iLF82_1304.LF82_1533,iNRG857_1313.NRG857_08815	Escherichia	1RCZM@1224,1S67W@1236,3XPNM@561,COG0494@1,COG0494@2	NA|NA|NA	L	Belongs to the Nudix hydrolase family
b1760	316407.85675111	4.4e-45	186.8	Escherichia	ynjH												Escherichia	1NB7M@1224,1SCHX@1236,2E3JA@1,32YHQ@2,3XPYD@561	NA|NA|NA	S	Protein of unknown function (DUF1496)
b1761	316407.1742869	1.6e-257	894.8	Escherichia	gdhA	GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100		R00248	RC00006,RC02799	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_2481,iECSP_1301.ECSP_2329,iECs_1301.ECs2467,iG2583_1286.G2583_2207,iSDY_1059.SDY_1514,iZ_1308.Z2793	Escherichia	1MUMF@1224,1RPUZ@1236,3XMVU@561,COG0334@1,COG0334@2	NA|NA|NA	E	Belongs to the Glu Leu Phe Val dehydrogenases family
b1762	316407.85675112	7.8e-207	726.1	Gammaproteobacteria													Escherichia	1R9IQ@1224,1S1XT@1236,2BUS6@1,32Q3H@2	NA|NA|NA	S	Protein of unknown function (DUF1266)
b1763	316407.1742870	0.0	1321.6	Escherichia	topB	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0007049,GO:0007059,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0022402,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051304,GO:0071704,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03169					ko00000,ko01000,ko03032				Escherichia	1MUFZ@1224,1RN4X@1236,3XP4A@561,COG0550@1,COG0550@2	NA|NA|NA	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
b1764	316407.85675113	5.1e-198	696.8	Escherichia	selD	GO:0000287,GO:0001887,GO:0003674,GO:0003824,GO:0004756,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009451,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019752,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0070329,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100		R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016			iSFV_1184.SFV_1453,iSF_1195.SF1459,iSFxv_1172.SFxv_1645,iS_1188.S1574	Escherichia	1MWFG@1224,1RQ5Q@1236,3XNEC@561,COG0709@1,COG0709@2	NA|NA|NA	F	Synthesizes selenophosphate from selenide and ATP
b1765	155864.EDL933_2725	2.6e-100	371.3	Escherichia	ydjA	GO:0000166,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0097159,GO:0097367,GO:1901265,GO:1901363											Escherichia	1PKUV@1224,1RNQG@1236,3XNE4@561,COG0778@1,COG0778@2	NA|NA|NA	C	FMN binding
b1766	316407.1742877	0.0	1211.8	Escherichia	sppA	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564		ko:K04773					ko00000,ko01000,ko01002				Escherichia	1MUXE@1224,1RNYW@1236,3XP8X@561,COG0616@1,COG0616@2	NA|NA|NA	OU	signal peptide peptidase
b1767	316407.1742878	4.8e-193	680.2	Escherichia	ansA	GO:0003674,GO:0003824,GO:0004067,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006530,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032787,GO:0033345,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:0072329,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110		R00485	RC00010,RC02798	ko00000,ko00001,ko01000			iECO103_1326.ECO103_1961,iSF_1195.SF1456,iS_1188.S1571	Escherichia	1MWIR@1224,1RMUB@1236,3XP19@561,COG0252@1,COG0252@2	NA|NA|NA	EJ	asparagine catabolic process via L-aspartate
b1768	316407.1742879	6e-125	453.4	Escherichia	pncA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100		R01268	RC00100	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_1895,iECs_1301.ECs2475,iZ_1308.Z2802	Escherichia	1MUGW@1224,1RZBF@1236,3XNAR@561,COG1335@1,COG1335@2	NA|NA|NA	Q	nicotinamidase activity
b1769	316407.1742880	3.8e-246	857.1	Gammaproteobacteria													Escherichia	1QUAJ@1224,1S18U@1236,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b1770	316407.1742881	9.8e-135	486.1	Gammaproteobacteria													Escherichia	1R7X3@1224,1S09E@1236,COG1349@1,COG1349@2	NA|NA|NA	K	transcriptional regulator
b1771	316407.1742882	2.2e-187	661.4	Escherichia	ydjG	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0019170,GO:0055114		ko:K18471	ko00640,map00640		R10718	RC00739	ko00000,ko00001,ko01000				Escherichia	1MVEH@1224,1RZSW@1236,3XRJ3@561,COG0667@1,COG0667@2	NA|NA|NA	C	Catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It is not known if this activity has physiological significance. Cannot use NADPH as a cosubstrate. Seems to play some role in intestinal colonization
b1772	316407.85675114	6e-174	616.7	Escherichia	ydjH												Escherichia	1MV6I@1224,1RSHQ@1236,3XQ2Z@561,COG0524@1,COG0524@2	NA|NA|NA	G	phosphotransferase activity, alcohol group as acceptor
b1773	316407.1742884	9.1e-158	562.8	Escherichia	ydjI											iAPECO1_1312.APECO1_842,iECOK1_1307.ECOK1_1892,iECS88_1305.ECS88_1825,iUMN146_1321.UM146_08280,iUTI89_1310.UTI89_C1969	Escherichia	1Q2AF@1224,1RSPE@1236,3XM6U@561,COG0191@1,COG0191@2	NA|NA|NA	G	aldehyde-lyase activity
b1774	316407.1742893	3.2e-200	704.1	Escherichia													Escherichia	1MV9A@1224,1RMNY@1236,3XPEF@561,COG1063@1,COG1063@2	NA|NA|NA	E	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
b1775	316407.85675115	4.9e-241	840.1	Escherichia	ydjK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08369					ko00000,ko02000	2.A.1			Escherichia	1QUCH@1224,1T1T9@1236,3XR4D@561,COG2271@1,COG2271@2	NA|NA|NA	P	transmembrane transporter activity
b1776	316407.1742895	4.9e-212	743.4	Escherichia	ydjL												Escherichia	1R73D@1224,1RQIW@1236,3XRI5@561,COG1063@1,COG1063@2	NA|NA|NA	C	zinc ion binding
b1777	316407.85675116	2.2e-44	184.5	Escherichia	yeaC			ko:K09916					ko00000				Escherichia	1N6T3@1224,1SCFV@1236,3XQ1U@561,COG3139@1,COG3139@2	NA|NA|NA	S	Protein of unknown function (DUF1315)
b1778	155864.EDL933_2742	3.8e-80	303.9	Escherichia	msrB	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019538,GO:0030091,GO:0033743,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564	1.8.4.12	ko:K07305					ko00000,ko01000			iAF1260.b1778,iB21_1397.B21_01735,iBWG_1329.BWG_1591,iE2348C_1286.E2348C_1905,iEC042_1314.EC042_1944,iEC55989_1330.EC55989_1947,iECBD_1354.ECBD_1866,iECB_1328.ECB_01747,iECDH10B_1368.ECDH10B_1916,iECDH1ME8569_1439.ECDH1ME8569_1722,iECD_1391.ECD_01747,iECH74115_1262.ECH74115_2502,iECIAI39_1322.ECIAI39_1275,iECNA114_1301.ECNA114_1824,iECO103_1326.ECO103_1964,iECP_1309.ECP_1726,iECSE_1348.ECSE_1949,iECSF_1327.ECSF_1639,iECSP_1301.ECSP_2350,iECUMN_1333.ECUMN_2067,iECW_1372.ECW_m1947,iECs_1301.ECs2487,iEKO11_1354.EKO11_1997,iETEC_1333.ETEC_1810,iEcDH1_1363.EcDH1_1864,iEcE24377_1341.EcE24377A_2002,iEcSMS35_1347.EcSMS35_1413,iG2583_1286.G2583_2225,iJO1366.b1778,iLF82_1304.LF82_1402,iNRG857_1313.NRG857_08905,iSSON_1240.SSON_1385,iWFL_1372.ECW_m1947,iY75_1357.Y75_RS09320,iZ_1308.Z2817	Escherichia	1RGWC@1224,1S5WI@1236,3XM35@561,COG0229@1,COG0229@2	NA|NA|NA	O	peptide-methionine (R)-S-oxide reductase activity
b1779	155864.EDL933_2743	4.2e-186	657.1	Escherichia	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147			iAPECO1_1312.APECO1_847,iUTI89_1310.UTI89_C1975,ic_1306.c2184	Escherichia	1MU93@1224,1RMBM@1236,3XNHT@561,COG0057@1,COG0057@2	NA|NA|NA	F	Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG
b1780	316407.1742898	1.4e-172	612.1	Escherichia	yeaD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	5.1.3.15	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130		R02739	RC00563	ko00000,ko00001,ko01000				Escherichia	1Q7VN@1224,1RQK0@1236,3XMHK@561,COG0676@1,COG0676@2	NA|NA|NA	G	Belongs to the glucose-6-phosphate 1-epimerase family
b1781	316407.85675118	2.9e-159	567.8	Escherichia	yeaE	GO:0003674,GO:0003824,GO:0006081,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0051596,GO:0055114,GO:0071704,GO:1901575										iAF1260.b1781,iB21_1397.B21_01738,iBWG_1329.BWG_1594,iECBD_1354.ECBD_1863,iECB_1328.ECB_01750,iECDH10B_1368.ECDH10B_1919,iECDH1ME8569_1439.ECDH1ME8569_1725,iECD_1391.ECD_01750,iEcDH1_1363.EcDH1_1861,iEcHS_1320.EcHS_A1866,iEcolC_1368.EcolC_1851,iJO1366.b1781,iY75_1357.Y75_RS09335	Escherichia	1MUH2@1224,1RMK5@1236,3XNVM@561,COG0656@1,COG0656@2	NA|NA|NA	S	methylglyoxal catabolic process
b1782	198214.SF1441	9.3e-146	522.7	Gammaproteobacteria													Escherichia	1MWQN@1224,1RQTM@1236,COG3713@1,COG3713@2	NA|NA|NA	M	MltA-interacting protein
b1783	1440052.EAKF1_ch4267c	0.0	1300.8	Escherichia	yeaG	GO:0003674,GO:0003824,GO:0004672,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0042594,GO:0043170,GO:0043412,GO:0043562,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0140096,GO:1901564		ko:K07180					ko00000				Escherichia	1MVW7@1224,1RNFJ@1236,3XNP5@561,COG2766@1,COG2766@2	NA|NA|NA	T	cellular response to nitrogen levels
b1784	316407.1736412	1.5e-228	798.5	Escherichia	yeaH			ko:K09786					ko00000				Escherichia	1MWQM@1224,1RQWC@1236,3XPFD@561,COG2718@1,COG2718@2	NA|NA|NA	S	Belongs to the UPF0229 family
b1785	316407.1736413	2.4e-270	937.6	Escherichia	yeaI	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032879,GO:0040012,GO:0040013,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0065007,GO:0071944,GO:1902021,GO:1902201,GO:2000145,GO:2000146										iAPECO1_1312.APECO1_853	Escherichia	1RGCV@1224,1T2TE@1236,3XPCJ@561,COG2199@1,COG2199@2	NA|NA|NA	T	negative regulation of cell motility
b1786	316407.85675119	1.7e-279	968.0	Escherichia	yeaJ	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032879,GO:0040012,GO:0040013,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0065007,GO:0071944,GO:1902021,GO:1902201,GO:2000145,GO:2000146											Escherichia	1P3SE@1224,1SSZV@1236,3XMW0@561,COG2199@1,COG2199@2	NA|NA|NA	T	negative regulation of cell motility
b1787	155864.EDL933_2751	8.6e-87	326.2	Escherichia	yeaK	GO:0002161,GO:0002196,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006417,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0045727,GO:0045903,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:2000112		ko:K19055					ko00000,ko01000,ko03016				Escherichia	1R9YR@1224,1S27F@1236,3XMST@561,COG2606@1,COG2606@2	NA|NA|NA	S	Ser-tRNA(Ala) hydrolase activity
b1789	198214.SF1435	8.5e-70	269.6	Gammaproteobacteria													Escherichia	1RA7I@1224,1S2D6@1236,COG2707@1,COG2707@2	NA|NA|NA	S	UPF0756 membrane protein
b1790	316407.85675122	1.1e-155	555.8	Escherichia	yeaM	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006089,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019219,GO:0019222,GO:0019243,GO:0019249,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0045892,GO:0045934,GO:0046185,GO:0046394,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051596,GO:0060255,GO:0061727,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141											Escherichia	1NETZ@1224,1RQ20@1236,3XQW1@561,COG2207@1,COG2207@2	NA|NA|NA	K	Negatively regulates expression of the nimT operon and its own expression. Acts by binding to the nimR-nimT intergenic region
b1791	316407.1736416	4.4e-214	750.4	Escherichia	yeaN	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944		ko:K03449					ko00000,ko02000	2.A.1.17			Escherichia	1MXGT@1224,1RNWA@1236,3XMU7@561,COG2807@1,COG2807@2	NA|NA|NA	P	response to antibiotic
b1792	316407.85675123	1.6e-60	238.4	Escherichia	yeaO												Escherichia	1MZ7H@1224,1S9PQ@1236,3XPSR@561,COG3189@1,COG3189@2	NA|NA|NA	S	Protein of unknown function, DUF488
b1793	198214.SF1431	5e-43	179.9	Gammaproteobacteria													Escherichia	1N8JF@1224,1SCRE@1236,COG3042@1,COG3042@2	NA|NA|NA	S	hemolysin
b1794	316407.1736420	2.2e-190	671.4	Escherichia	yeaP	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621	2.7.7.65	ko:K13069			R08057		ko00000,ko01000				Escherichia	1MVSA@1224,1RP1K@1236,3XMBK@561,COG2199@1,COG2199@2,COG2203@1,COG2203@2	NA|NA|NA	T	diguanylate cyclase activity
b4676	469008.B21_04542	7.6e-08	61.6	Escherichia	yoaK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1NMS7@1224,1SIA4@1236,2EMMP@1,33FA1@2,3XRBR@561	NA|NA|NA		
b1795	155864.EDL933_2762	5.3e-37	159.8	Escherichia	yeaQ												Escherichia	1N72W@1224,1S8YP@1236,3XR58@561,COG2261@1,COG2261@2	NA|NA|NA	S	Transglycosylase associated protein
b1796	155864.EDL933_2763	1.7e-21	107.8	Escherichia	yoaG												Escherichia	1RJTW@1224,1SAQ5@1236,2BFDU@1,32979@2,3XQ3U@561	NA|NA|NA	S	Domain of unknown function (DUF1869)
b1797	155864.EDL933_2764	1.6e-66	258.5	Escherichia	yeaR												Escherichia	1RFYQ@1224,1S3XP@1236,3XPKQ@561,COG3615@1,COG3615@2	NA|NA|NA	P	Domain of unknown function (DUF1971)
b1798	316407.1736421	9.2e-110	402.9	Escherichia	leuE	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015190,GO:0015318,GO:0015658,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015820,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0042968,GO:0042970,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K11250					ko00000,ko02000	2.A.76.1.5			Escherichia	1RA1G@1224,1RSYH@1236,3XPDM@561,COG1280@1,COG1280@2	NA|NA|NA	E	efflux protein
b1799	316407.1736422	1e-173	615.9	Escherichia	dmlR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006082,GO:0006108,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043436,GO:0043565,GO:0043648,GO:0044237,GO:0044281,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K16135					ko00000,ko03000				Escherichia	1MVJ7@1224,1RMNJ@1236,3XPY5@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
b1800	316407.1736423	4.3e-216	756.9	Escherichia	dmlA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0006082,GO:0006108,GO:0008150,GO:0008152,GO:0009027,GO:0009987,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0019752,GO:0036094,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046553,GO:0046872,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650		R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000			iSBO_1134.SBO_1288	Escherichia	1MUH4@1224,1RRPI@1236,3XQKY@561,COG0473@1,COG0473@2	NA|NA|NA	C	Catalyzes the NAD( )-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D- malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in those conditions. Appears to be not able to use L- tartrate as a substrate for dehydrogenation instead of D-malate
b1801	155864.EDL933_2769	1.3e-276	958.4	Escherichia	yeaV	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071705,GO:0071944		ko:K03451					ko00000	2.A.15		iEcSMS35_1347.EcSMS35_1387	Escherichia	1MV0K@1224,1RP3E@1236,3XQSW@561,COG1292@1,COG1292@2	NA|NA|NA	M	nitrogen compound transport
b1802	155864.EDL933_2770	3e-228	797.3	Escherichia	yeaW	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043933,GO:0044085,GO:0048037,GO:0051259,GO:0051260,GO:0051536,GO:0051537,GO:0051540,GO:0065003,GO:0070206,GO:0070207,GO:0071840	1.14.13.239	ko:K22443					ko00000,ko01000				Escherichia	1MWXW@1224,1RYN7@1236,3XQJJ@561,COG4638@1,COG4638@2	NA|NA|NA	P	Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily
b1803	316407.1736426	3.3e-183	647.5	Escherichia	yeaX		1.14.13.239	ko:K22444					ko00000,ko01000				Escherichia	1MU6E@1224,1RNA4@1236,3XQNN@561,COG1018@1,COG1018@2	NA|NA|NA	C	Converts carnitine to trimethylamine and malic semialdehyde. Can also use gamma-butyrobetaine, choline and betaine as substrates
b1804	316407.1736427	1.1e-217	762.3	Escherichia	rnd	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0033890,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360	3.1.13.5	ko:K03684					ko00000,ko01000,ko03016				Escherichia	1MURV@1224,1RPBP@1236,3XM58@561,COG0349@1,COG0349@2	NA|NA|NA	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
b1805	199310.c2209	0.0	1128.2	Escherichia	fadD	GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006644,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009898,GO:0009987,GO:0015645,GO:0016020,GO:0016042,GO:0016054,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0030258,GO:0031406,GO:0032787,GO:0033293,GO:0033865,GO:0033875,GO:0034032,GO:0034440,GO:0034641,GO:0035383,GO:0036041,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046395,GO:0046483,GO:0050896,GO:0051186,GO:0055086,GO:0055114,GO:0070538,GO:0071704,GO:0071944,GO:0072329,GO:0072521,GO:0090407,GO:0098552,GO:0098562,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901576	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1		iSF_1195.SF1423,iSFxv_1172.SFxv_1611,iS_1188.S1538	Escherichia	1MU6G@1224,1RMQ4@1236,3XMU8@561,COG0318@1,COG0318@2	NA|NA|NA	IQ	Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids
b1806	199310.c2210	2.9e-102	377.9	Escherichia	yeaY			ko:K07285					ko00000				Escherichia	1MZ8C@1224,1S9UB@1236,3XPCY@561,COG3065@1,COG3065@2	NA|NA|NA	M	Outer membrane lipoprotein Slp family
b1807	316407.1736440	4.6e-131	473.8	Escherichia	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564		ko:K14742					ko00000,ko03016				Escherichia	1MXPH@1224,1RPYX@1236,3XMQ9@561,COG1214@1,COG1214@2	NA|NA|NA	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD. In fact, can act as a protease that specifically degrades TsaD in vitro
b1808	316407.1736447	0.0	1255.0	Escherichia	yoaA	GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360	3.6.4.12	ko:K03722					ko00000,ko01000,ko03400				Escherichia	1MVCU@1224,1RMNX@1236,3XN9U@561,COG1199@1,COG1199@2	NA|NA|NA	KL	postreplication repair
b1809	155864.EDL933_2777	7.5e-58	229.6	Escherichia	yoaB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MZ5K@1224,1S5WM@1236,3XPPG@561,COG0251@1,COG0251@2	NA|NA|NA	J	Endoribonuclease L-PSP
b1810	155864.EDL933_2780	3.2e-49	200.7	Escherichia	yoaC												Escherichia	1MZA9@1224,1SAKQ@1236,2DMW3@1,32UHS@2,3XQ17@561	NA|NA|NA	S	Domain of unknown function (DUF1889)
b1811	1440052.EAKF1_ch4240	1.2e-22	111.7	Escherichia	yoaH			ko:K09917					ko00000				Escherichia	1N89H@1224,1SCHP@1236,3XQ2T@561,COG3140@1,COG3140@2	NA|NA|NA	S	Belongs to the UPF0181 family
b1812	316407.1736449	4.5e-263	913.3	Escherichia	pabB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.6.1.85	ko:K01665	ko00790,map00790		R01716	RC00010,RC01418	ko00000,ko00001,ko01000			iEC042_1314.EC042_1977	Escherichia	1MVBJ@1224,1RMSE@1236,3XMTG@561,COG0147@1,COG0147@2	NA|NA|NA	EH	Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabB, in the absence of PabA, can catalyze the formation of ADC in the presence of exogenous ammonia
b1813	316407.1736450	5.8e-103	380.2	Escherichia	nudL	GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818											Escherichia	1RD2C@1224,1SA4Q@1236,3XMZ7@561,COG0494@1,COG0494@2	NA|NA|NA	F	Probably mediates the hydrolysis of some nucleoside diphosphate derivatives
b1814	316407.1736451	3.2e-261	907.1	Escherichia	sdaA	GO:0003674,GO:0003824,GO:0003941,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006565,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230		R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000			iECUMN_1333.ECUMN_2106	Escherichia	1MUZN@1224,1RMJZ@1236,3XN8Q@561,COG1760@1,COG1760@2	NA|NA|NA	E	L-serine dehydratase 1
b1815	316407.1736452	1.3e-306	1058.1	Escherichia	yoaD	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	3.1.4.52	ko:K21090	ko02026,map02026				ko00000,ko00001,ko01000				Escherichia	1QUCV@1224,1T1TN@1236,3XNZ2@561,COG2200@1,COG2200@2	NA|NA|NA	T	overexpression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
b1816	155864.EDL933_2786	7.4e-286	989.2	Escherichia	yoaE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1QTUN@1224,1RMTY@1236,3XNWV@561,COG1253@1,COG1253@2	NA|NA|NA	P	UPF0053 inner membrane protein YoaE
b1817	155864.EDL933_2787	1.5e-167	595.5	Escherichia	manX	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006793,GO:0006796,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0008645,GO:0008982,GO:0009401,GO:0009987,GO:0015144,GO:0015145,GO:0015149,GO:0015578,GO:0015749,GO:0015761,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0022870,GO:0031224,GO:0031226,GO:0034219,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046323,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098657,GO:0098704,GO:0098708,GO:0098739,GO:1904659	2.7.1.191	ko:K02793,ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1		iAPECO1_1312.APECO1_874,iECOK1_1307.ECOK1_1934,iECS88_1305.ECS88_1869,iUMN146_1321.UM146_08085,iUTI89_1310.UTI89_C2014	Escherichia	1RHH7@1224,1RNAT@1236,3XMS9@561,COG2893@1,COG2893@2,COG3444@1,COG3444@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA
b1818	155864.EDL933_2788	2.3e-134	485.0	Escherichia	manY	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0008982,GO:0009401,GO:0015144,GO:0015145,GO:0015149,GO:0015578,GO:0015749,GO:0015761,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0022870,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0046323,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098657,GO:0098704,GO:0098708,GO:0098739,GO:1904659		ko:K02795	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1		e_coli_core.b1818,iAF1260.b1818,iAPECO1_1312.APECO1_875,iB21_1397.B21_01776,iBWG_1329.BWG_1631,iE2348C_1286.E2348C_1942,iEC55989_1330.EC55989_1991,iECABU_c1320.ECABU_c20770,iECBD_1354.ECBD_1823,iECB_1328.ECB_01788,iECDH10B_1368.ECDH10B_1956,iECDH1ME8569_1439.ECDH1ME8569_1763,iECD_1391.ECD_01788,iECED1_1282.ECED1_2021,iECH74115_1262.ECH74115_2547,iECIAI1_1343.ECIAI1_1887,iECIAI39_1322.ECIAI39_1234,iECNA114_1301.ECNA114_1863,iECO103_1326.ECO103_2008,iECO111_1330.ECO111_2325,iECO26_1355.ECO26_2588,iECOK1_1307.ECOK1_1935,iECP_1309.ECP_1761,iECS88_1305.ECS88_1870,iECSE_1348.ECSE_1992,iECSF_1327.ECSF_1674,iECSP_1301.ECSP_2391,iECUMN_1333.ECUMN_2110,iECW_1372.ECW_m1988,iECs_1301.ECs2528,iEKO11_1354.EKO11_1954,iETEC_1333.ETEC_1850,iEcDH1_1363.EcDH1_1825,iEcHS_1320.EcHS_A1908,iEcSMS35_1347.EcSMS35_1370,iEcolC_1368.EcolC_1814,iG2583_1286.G2583_2267,iJO1366.b1818,iJR904.b1818,iLF82_1304.LF82_1272,iNRG857_1313.NRG857_09090,iSBO_1134.SBO_1230,iSFV_1184.SFV_1411,iSF_1195.SF1410,iSFxv_1172.SFxv_1597,iSSON_1240.SSON_1342,iS_1188.S1525,iSbBS512_1146.SbBS512_E2084,iUMN146_1321.UM146_08080,iUMNK88_1353.UMNK88_2288,iUTI89_1310.UTI89_C2015,iWFL_1372.ECW_m1988,iY75_1357.Y75_RS09530,iZ_1308.Z2861,ic_1306.c2224	Escherichia	1MWFP@1224,1RN34@1236,3XM9G@561,COG3715@1,COG3715@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA
b1819	155864.EDL933_2789	1.3e-156	558.9	Escherichia	manZ	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0008982,GO:0009401,GO:0015144,GO:0015145,GO:0015149,GO:0015578,GO:0015749,GO:0015761,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0022870,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0046323,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098657,GO:0098704,GO:0098708,GO:0098739,GO:1904659		ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1		iECIAI1_1343.ECIAI1_1888,iECP_1309.ECP_1762,iSBO_1134.SBO_1231,iSF_1195.SF1409,iSFxv_1172.SFxv_1596,iS_1188.S1524	Escherichia	1MWTZ@1224,1RNSD@1236,3XNSC@561,COG3716@1,COG3716@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA
b1820	199310.c2227	2e-74	285.0	Escherichia	yobD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RDEQ@1224,1S3UZ@1236,3XMU3@561,COG4811@1,COG4811@2	NA|NA|NA	S	UPF0266 membrane protein YobD
b1821	155864.EDL933_2793	1.1e-98	365.9	Escherichia	mntP	GO:0000041,GO:0003674,GO:0005215,GO:0005384,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006828,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010042,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0042221,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071421,GO:0071944,GO:0098655,GO:0098660,GO:0098662											Escherichia	1NWBY@1224,1RR6R@1236,3XMT7@561,COG1971@1,COG1971@2	NA|NA|NA	P	Probably functions as a manganese efflux pump
b1822	316407.1736466	2.6e-157	561.2	Escherichia	rlmA	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008270,GO:0008649,GO:0008757,GO:0008989,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.187	ko:K00563			R07233	RC00003	ko00000,ko01000,ko03009				Escherichia	1MXDY@1224,1RMU7@1236,3XMMW@561,COG0500@1,COG2226@2	NA|NA|NA	J	Ribosomal RNA large subunit methyltransferase A
b1823	1005994.GTGU_00244	1.9e-32	144.4	Gammaproteobacteria													Escherichia	1N6Q5@1224,1SCA7@1236,COG1278@1,COG1278@2	NA|NA|NA	K	Cold shock
b1824	155864.EDL933_2796	1.4e-18	97.8	Escherichia													Escherichia	1NKY9@1224,1SHPB@1236,2EQ5Q@1,33HS0@2,3XRBN@561	NA|NA|NA	S	Protein of unknown function (DUF2627)
b1825	199310.c2233	1e-39	169.1	Escherichia	yebO												Escherichia	1N0RQ@1224,1S9E7@1236,2CGCJ@1,32S3N@2,3XPY1@561	NA|NA|NA	S	YebO-like protein
b1826	198214.SF1400	1.4e-18	97.8	Gammaproteobacteria													Escherichia	1N9MV@1224,1SDNM@1236,2E94K@1,333DF@2	NA|NA|NA	S	PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing. MgrB acts between DsbA DsbB and PhoP PhoQ in this pathway. Represses PhoP PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP
b4536	199310.c2235	7.3e-36	156.0	Escherichia	yobH												Escherichia	1N493@1224,1S97R@1236,2CYZ3@1,32T57@2,3XQ3X@561	NA|NA|NA	S	YobH-like protein
b1827	316407.1736468	3.9e-142	510.8	Escherichia	kdgR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K19333					ko00000,ko03000				Escherichia	1MUNW@1224,1RR06@1236,3XP0S@561,COG1414@1,COG1414@2	NA|NA|NA	K	Transcriptional regulator
b1828	316407.1736469	6.8e-243	846.3	Escherichia	yebQ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K08169					ko00000,ko02000	2.A.1.3.17			Escherichia	1QUAS@1224,1RPFC@1236,3XP7S@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b1829	316407.1736470	4.9e-154	550.4	Escherichia	htpX	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009266,GO:0009628,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044425,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564		ko:K03799		M00743			ko00000,ko00002,ko01000,ko01002				Escherichia	1MUV4@1224,1RMN0@1236,3XPBP@561,COG0501@1,COG0501@2	NA|NA|NA	O	Heat shock protein HtpX
b1830	316407.1736471	0.0	1328.9	Escherichia	prc	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.102	ko:K03797					ko00000,ko01000,ko01002				Escherichia	1MU39@1224,1RMSR@1236,3XN0R@561,COG0793@1,COG0793@2	NA|NA|NA	M	Belongs to the peptidase S41A family
b1831	316407.85675139	6.4e-88	330.5	Escherichia	proQ	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003727,GO:0003729,GO:0003730,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0007154,GO:0007165,GO:0007231,GO:0008150,GO:0009628,GO:0009651,GO:0009987,GO:0010468,GO:0010608,GO:0010958,GO:0019222,GO:0023052,GO:0032879,GO:0032890,GO:0032892,GO:0033554,GO:0033592,GO:0034057,GO:0034762,GO:0034764,GO:0034765,GO:0034767,GO:0042538,GO:0042710,GO:0043269,GO:0043270,GO:0044010,GO:0044070,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051704,GO:0051716,GO:0051952,GO:0051954,GO:0051955,GO:0051957,GO:0060255,GO:0065007,GO:0070881,GO:0071214,GO:0071470,GO:0071472,GO:0071474,GO:0071475,GO:0097159,GO:0097617,GO:0104004,GO:1901363,GO:1902834,GO:1902836,GO:1903789,GO:1903793,GO:1903959,GO:1903961,GO:1904062,GO:1904064		ko:K03607					ko00000				Escherichia	1N68T@1224,1RP4S@1236,3XNSN@561,COG3109@1,COG3109@2	NA|NA|NA	T	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism
b1832	316407.1736473	7.7e-88	329.7	Escherichia	yebR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0033745,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.8.4.14	ko:K08968	ko00270,map00270		R02025	RC00639	ko00000,ko00001,ko01000				Escherichia	1RDBM@1224,1S6QU@1236,3XN26@561,COG1956@1,COG1956@2	NA|NA|NA	T	L-methionine-(R)-S-oxide reductase activity
b1833	316407.1736474	4.9e-243	846.7	Escherichia	yebS	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944		ko:K03808					ko00000				Escherichia	1MWG1@1224,1RM9Z@1236,3XM56@561,COG2995@1,COG2995@2	NA|NA|NA	S	response to heat
b1834	316407.1736481	0.0	1726.5	Escherichia	yebT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0016020,GO:0016021,GO:0016043,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071840,GO:0071944,GO:0120009											Escherichia	1MU1T@1224,1RN89@1236,3XNTJ@561,COG3008@1,COG3008@2	NA|NA|NA	Q	intermembrane lipid transfer
b1835	316407.85675140	7.5e-285	985.7	Escherichia	rsmF	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.178	ko:K11392					ko00000,ko01000,ko03009				Escherichia	1NAY1@1224,1RP74@1236,3XP8F@561,COG0144@1,COG0144@2,COG3270@1,COG3270@2	NA|NA|NA	J	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
b1836	155864.EDL933_2809	4.8e-40	169.9	Escherichia	yebV												Escherichia	1N1QN@1224,1S96J@1236,2D1TW@1,32TBC@2,3XQ0D@561	NA|NA|NA	S	Protein of unknown function (DUF1480)
b1837	316407.85675142	1.9e-31	141.0	Escherichia	yebW												Escherichia	1N7FC@1224,1SCUH@1236,2E3KM@1,32YIX@2,3XQ3A@561	NA|NA|NA	S	Protein of unknown function (DUF1482)
b1838	316407.85675143	3.6e-133	480.7	Escherichia	pphA	GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0009266,GO:0009628,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:0140096,GO:1901564	3.1.3.16	ko:K07313					ko00000,ko01000				Escherichia	1N106@1224,1S9QJ@1236,3XNX2@561,COG0639@1,COG0639@2	NA|NA|NA	T	Plays a key role in signaling protein misfolding via the CpxR CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr and Tyr-phosphorylated substrates
b1839	198214.SF1850	9.1e-56	222.6	Gammaproteobacteria													Escherichia	1N3F9@1224,1SAPJ@1236,2DMVD@1,32TXR@2	NA|NA|NA	S	Protein of unknown function (DUF2511)
b1840	316407.85675145	3.9e-159	567.4	Escherichia	yebZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07245					ko00000,ko02000	9.B.62.1			Escherichia	1P1D5@1224,1RYS7@1236,3XMS8@561,COG1276@1,COG1276@2	NA|NA|NA	P	copper ion transport
b1841	198214.SF1852	8.4e-63	246.1	Gammaproteobacteria													Escherichia	1N8SS@1224,1S9EF@1236,COG2372@1,COG2372@2	NA|NA|NA	S	Resistance protein
b1842	155864.EDL933_2815	2.3e-34	151.0	Escherichia	holE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009360,GO:0032991,GO:0042575,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0061695,GO:1902494,GO:1990234	2.7.7.7	ko:K02345	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Escherichia	1MZTI@1224,1S8YF@1236,2CFYS@1,32S2T@2,3XPYS@561	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
b1843	316407.85675147	1e-124	452.6	Escherichia	yobB												Escherichia	1RESJ@1224,1S5NI@1236,3XPIU@561,COG0388@1,COG0388@2	NA|NA|NA	S	nitrogen compound metabolic process
b1844	199310.c2254	3.5e-128	464.2	Escherichia	exoX	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:1901360		ko:K10857	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Escherichia	1PDD1@1224,1RNSI@1236,3XNFX@561,COG0847@1,COG0847@2	NA|NA|NA	L	Capable of degrading both single-strand and double- strand DNA with 3' to 5' polarity. Has higher affinity for ssDNA ends than for dsDNA
b1845	316407.1736485	0.0	1431.8	Escherichia	ptrB	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143				ko00000,ko00001,ko01000,ko01002				Escherichia	1MUED@1224,1RMSV@1236,3XPAW@561,COG1770@1,COG1770@2	NA|NA|NA	E	oligopeptidase activity
b1846	316407.1736486	1.3e-114	419.1	Escherichia	yebE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1R95E@1224,1T0I8@1236,3XRFE@561,COG2979@1,COG2979@2	NA|NA|NA	S	Protein of unknown function (DUF533)
b1847	316407.1736487	5.8e-61	240.0	Escherichia	yebF												Escherichia	1RIMG@1224,1S6EJ@1236,2DM3Z@1,31MN2@2,3XPTU@561	NA|NA|NA	S	YebF-like protein
b1848	155864.EDL933_2821	1.4e-44	185.3	Escherichia	yebG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0010165,GO:0010212,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360		ko:K09918					ko00000				Escherichia	1N6RQ@1224,1SCDB@1236,3XPUH@561,COG3141@1,COG3141@2	NA|NA|NA	S	response to X-ray
b1849	316407.85675149	1e-218	765.8	Escherichia	purT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008776,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044444,GO:0044464	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_1135	Escherichia	1N3KA@1224,1RNTW@1236,3XMXH@561,COG0027@1,COG0027@2	NA|NA|NA	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
b1850	1440052.EAKF1_ch4190	3.1e-113	414.5	Escherichia	eda	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008675,GO:0008700,GO:0008948,GO:0016829,GO:0016830,GO:0016831,GO:0016832,GO:0016833,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0106009	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000			iECOK1_1307.ECOK1_1968	Escherichia	1MUVJ@1224,1RPDF@1236,3XNXS@561,COG0800@1,COG0800@2	NA|NA|NA	G	Involved in the degradation of glucose via the Entner- Doudoroff pathway. Catalyzes the reversible, stereospecific retro- aldol cleavage of 2-Keto-3-deoxy-6-phosphogluconate (KDPG) to pyruvate and D-glyceraldehyde-3-phosphate. In the synthetic direction, it catalyzes the addition of pyruvate to electrophilic aldehydes with si-facial selectivity. It accepts some nucleophiles other than pyruvate, including 2-oxobutanoate, phenylpyruvate, and fluorobutanoate. It has a preference for the S-configuration at C2 of the electrophile
b1851	155864.EDL933_2824	0.0	1204.9	Escherichia	edd	GO:0003674,GO:0003824,GO:0004456,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019520,GO:0019521,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046177,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.2.1.12	ko:K01690	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00008	R02036	RC00543	ko00000,ko00001,ko00002,ko01000			iEcolC_1368.EcolC_1781	Escherichia	1MU3T@1224,1RMNA@1236,3XMWD@561,COG0129@1,COG0129@2	NA|NA|NA	EG	Belongs to the IlvD Edd family
b1852	199310.c2265	1.4e-289	1001.5	Escherichia	zwf	GO:0003674,GO:0003824,GO:0004345,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007267,GO:0008150,GO:0008152,GO:0009117,GO:0009372,GO:0009987,GO:0010699,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0023052,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0051704,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147			e_coli_core.b1852,iAF1260.b1852,iBWG_1329.BWG_1666,iE2348C_1286.E2348C_1977,iEC042_1314.EC042_2019,iECABU_c1320.ECABU_c21130,iECDH10B_1368.ECDH10B_1993,iECDH1ME8569_1439.ECDH1ME8569_1798,iECED1_1282.ECED1_2057,iECIAI39_1322.ECIAI39_1198,iECNA114_1301.ECNA114_1899,iECO26_1355.ECO26_2690,iECP_1309.ECP_1796,iECSF_1327.ECSF_1710,iECUMN_1333.ECUMN_2149,iECW_1372.ECW_m2026,iEKO11_1354.EKO11_1918,iEcDH1_1363.EcDH1_1789,iEcE24377_1341.EcE24377A_2082,iEcHS_1320.EcHS_A1944,iEcSMS35_1347.EcSMS35_1335,iEcolC_1368.EcolC_1780,iG2583_1286.G2583_2304,iJO1366.b1852,iJR904.b1852,iLF82_1304.LF82_3733,iNRG857_1313.NRG857_09280,iSDY_1059.SDY_1138,iWFL_1372.ECW_m2026,iY75_1357.Y75_RS09725,ic_1306.c2265	Escherichia	1MUN0@1224,1RN76@1236,3XNAE@561,COG0364@1,COG0364@2	NA|NA|NA	F	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
b1853	316407.1736496	2.9e-154	551.2	Escherichia	hexR	GO:0001130,GO:0001131,GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141		ko:K19337					ko00000,ko03000				Escherichia	1MV3U@1224,1RNC4@1236,3XM9I@561,COG1737@1,COG1737@2	NA|NA|NA	K	transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
b1854	316407.1736497	8.1e-263	912.5	Escherichia	pykA	GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147			iEcE24377_1341.EcE24377A_2084	Escherichia	1MU21@1224,1RMW3@1236,3XPGP@561,COG0469@1,COG0469@2	NA|NA|NA	F	Belongs to the pyruvate kinase family
b1855	316407.1736498	5.6e-191	673.3	Escherichia	msbB	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0046467,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.243	ko:K02560	ko00540,ko01100,map00540,map01100	M00060	R05075	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005			iECABU_c1320.ECABU_c21170,iECIAI39_1322.ECIAI39_1194,ic_1306.c2269	Escherichia	1N9ZJ@1224,1RRI7@1236,3XND2@561,COG1560@1,COG1560@2	NA|NA|NA	M	Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A
b1856	155864.EDL933_2830	2.3e-248	864.4	Escherichia	yebA	GO:0000270,GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008219,GO:0008233,GO:0008237,GO:0009987,GO:0012501,GO:0016787,GO:0019538,GO:0030203,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901564		ko:K19304					ko00000,ko01000,ko01002,ko01011				Escherichia	1MVTF@1224,1RM7S@1236,3XP5M@561,COG0739@1,COG0739@2	NA|NA|NA	M	A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH
b1857	316407.85675151	3.4e-161	574.3	Escherichia	znuA	GO:0000041,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008270,GO:0030001,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0051179,GO:0051234,GO:0070838,GO:0072511		ko:K09815	ko02010,map02010	M00242			ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5		iECs_1301.ECs2567,iEcSMS35_1347.EcSMS35_1329,iZ_1308.Z2909	Escherichia	1QTTI@1224,1RMRJ@1236,3XNZH@561,COG4531@1,COG4531@2	NA|NA|NA	P	Belongs to the bacterial solute-binding protein 9 family
b1858	155864.EDL933_2832	1.7e-139	501.9	Escherichia	znuC	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K09817	ko02010,map02010	M00242			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5		iSFV_1184.SFV_1859,iSF_1195.SF1867,iSFxv_1172.SFxv_2092,iS_1188.S1934	Escherichia	1MUDW@1224,1RPJT@1236,3XNTN@561,COG1121@1,COG1121@2	NA|NA|NA	P	Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system
b1859	316407.1736502	1e-118	433.0	Escherichia	znuB	GO:0000006,GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010043,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0042221,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662		ko:K09816	ko02010,map02010	M00242			ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5		iEC042_1314.EC042_2026,iECABU_c1320.ECABU_c21210,iECED1_1282.ECED1_2064,iECNA114_1301.ECNA114_1921,iECSF_1327.ECSF_1717,iECUMN_1333.ECUMN_2157,iEcSMS35_1347.EcSMS35_1327,iG2583_1286.G2583_2311,iSSON_1240.SSON_1282,ic_1306.c2273	Escherichia	1MVC2@1224,1RPYF@1236,3XMDE@561,COG1108@1,COG1108@2	NA|NA|NA	P	High-affinity zinc uptake system membrane protein ZnuB
b1860	155864.EDL933_2834	6e-188	663.3	Escherichia	ruvB	GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	3.6.4.12	ko:K03551	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Escherichia	1MU38@1224,1RNWY@1236,3XMBC@561,COG2255@1,COG2255@2	NA|NA|NA	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
b1861	155864.EDL933_2835	2.3e-105	388.3	Escherichia	ruvA	GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Escherichia	1MWJR@1224,1RMET@1236,3XMI2@561,COG0632@1,COG0632@2	NA|NA|NA	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
b1862	316407.85675152	4.9e-113	413.7	Escherichia	yebB												Escherichia	1PUT6@1224,1RYQC@1236,28IT1@1,2Z8S1@2,3XM6R@561	NA|NA|NA	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
b1863	1440052.EAKF1_ch4174	1.2e-88	332.4	Escherichia	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009314,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.22.4	ko:K01159	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Escherichia	1MUJI@1224,1RQPJ@1236,3XM8U@561,COG0817@1,COG0817@2	NA|NA|NA	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
b1864	316407.1736511	3.7e-134	484.2	Escherichia	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896											Escherichia	1MW3X@1224,1RP5N@1236,3XN2B@561,COG0217@1,COG0217@2	NA|NA|NA	K	transcriptional regulatory protein YebC
b1865	198214.SF1875	1.6e-79	302.0	Gammaproteobacteria													Escherichia	1RH6N@1224,1S20Q@1236,COG0494@1,COG0494@2	NA|NA|NA	L	dihydroneopterin triphosphate
b1866	316407.1736513	0.0	1180.2	Escherichia	aspS	GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iSFV_1184.SFV_1868	Escherichia	1MUXB@1224,1RNMI@1236,3XMSA@561,COG0173@1,COG0173@2	NA|NA|NA	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)
b1867	155864.EDL933_2841	4.3e-103	380.6	Escherichia	yecD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1QK2B@1224,1RYRR@1236,3XMT8@561,COG1335@1,COG1335@2	NA|NA|NA	Q	hydrolase activity
b1868	316407.85675153	9.2e-163	579.3	Escherichia	yecE												Escherichia	1MU7F@1224,1RSAG@1236,3XN7Z@561,COG1801@1,COG1801@2	NA|NA|NA	S	Protein of unknown function DUF72
b1869	155864.EDL933_2843	1.6e-67	261.9	Escherichia	yecN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07136					ko00000				Escherichia	1RDHP@1224,1S3PN@1236,3XPIH@561,COG3788@1,COG3788@2	NA|NA|NA	S	MAPEG family
b1870	316407.1736516	5.8e-140	503.4	Escherichia	cmoA	GO:0002097,GO:0002098,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K15256					ko00000,ko01000,ko03016				Escherichia	1MV4M@1224,1RMWY@1236,3XPCC@561,COG0500@1,COG2226@2	NA|NA|NA	J	Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM)
b1871	316407.1736517	7.8e-193	679.5	Escherichia	cmoB	GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016740,GO:0016741,GO:0016765,GO:0022607,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0090304,GO:1901360		ko:K15257					ko00000,ko01000,ko03016				Escherichia	1MVSK@1224,1RMQY@1236,3XNSV@561,COG0500@1,COG0500@2	NA|NA|NA	J	Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
b1872	316407.1736518	0.0	1660.6	Escherichia	torZ	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050626,GO:0055114	1.7.2.3	ko:K07812					ko00000,ko01000,ko02000	5.A.3.4		iNRG857_1313.NRG857_09385	Escherichia	1NR6J@1224,1RMVE@1236,3XNTP@561,COG0243@1,COG0243@2	NA|NA|NA	C	an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N-oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency
b1873	316407.1736519	9.4e-203	712.6	Escherichia	torY	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363		ko:K07821					ko00000,ko02000	5.A.3.4			Escherichia	1MWV2@1224,1RQ52@1236,3XP3J@561,COG3005@1,COG3005@2	NA|NA|NA	C	Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzyme
b1874	316407.1736520	6.5e-139	500.0	Escherichia	cutC	GO:0006873,GO:0006875,GO:0006878,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0019725,GO:0030003,GO:0042221,GO:0042592,GO:0046688,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771		ko:K06201					ko00000				Escherichia	1MV5W@1224,1RMC1@1236,3XP58@561,COG3142@1,COG3142@2	NA|NA|NA	P	Participates in the control of copper homeostasis
b1875	316407.85675155	7.7e-108	396.4	Escherichia	yecM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09907					ko00000				Escherichia	1RB98@1224,1RYG4@1236,3XP38@561,COG3102@1,COG3102@2	NA|NA|NA	S	YecM protein
b1876	316407.1736522	0.0	1140.2	Escherichia	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029			iECABU_c1320.ECABU_c21380,iECNA114_1301.ECNA114_1940,iECSE_1348.ECSE_2111,iECSF_1327.ECSF_1736,iEcolC_1368.EcolC_1756,iLF82_1304.LF82_0128,iNRG857_1313.NRG857_09405,iUMNK88_1353.UMNK88_2348,ic_1306.c2291	Escherichia	1MU4J@1224,1RPRC@1236,3XNTV@561,COG0018@1,COG0018@2	NA|NA|NA	J	arginyl-tRNA aminoacylation
b1877	316407.85675156	1.3e-87	328.9	Gammaproteobacteria													Escherichia	1NQ0A@1224,1SIE2@1236,COG3755@1,COG3755@2	NA|NA|NA	S	Lysozyme inhibitor LprI
b1878	316407.1736523	5.9e-67	260.0	Escherichia	flhE	GO:0005575,GO:0005623,GO:0006996,GO:0008150,GO:0009288,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0044781,GO:0071840		ko:K03516					ko00000,ko02035				Escherichia	1RF8K@1224,1S3YK@1236,294I9@1,2ZRXW@2,3XPT0@561	NA|NA|NA	N	Flagellar protein flhE
b1879	316407.85675157	0.0	1299.3	Escherichia	flhA	GO:0005575,GO:0005623,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0044085,GO:0044464,GO:0044780,GO:0044781,GO:0070925,GO:0071840,GO:0071944		ko:K02400	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Escherichia	1MUF3@1224,1RMSM@1236,3XMV8@561,COG1298@1,COG1298@2	NA|NA|NA	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
b1880	316407.1736533	4.9e-210	736.9	Escherichia	flhB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02401	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2			Escherichia	1MUWI@1224,1RMHA@1236,3XPDI@561,COG1377@1,COG1377@2	NA|NA|NA	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
b1881	199310.c2296	8.4e-111	406.4	Escherichia	cheZ	GO:0001539,GO:0003674,GO:0003824,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0032991,GO:0036211,GO:0040011,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071704,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0097588,GO:0098561,GO:0140096,GO:1901564		ko:K03414	ko02030,map02030				ko00000,ko00001,ko02035				Escherichia	1NIV6@1224,1RNG2@1236,3XM8Y@561,COG3143@1,COG3143@2	NA|NA|NA	J	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
b1882	155864.EDL933_2857	2.1e-64	251.5	Escherichia	cheY	GO:0000287,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006473,GO:0006475,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0016310,GO:0016407,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0023014,GO:0023052,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0048870,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0065007,GO:0071704,GO:0071973,GO:0097588,GO:1901564		ko:K03413	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko02022,ko02035				Escherichia	1RDNP@1224,1S47I@1236,3XPJY@561,COG0745@1,COG0745@2	NA|NA|NA	KT	Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation
b1883	316407.1736536	3.9e-190	670.6	Escherichia	cheB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006482,GO:0006807,GO:0006935,GO:0008150,GO:0008152,GO:0008214,GO:0008984,GO:0009605,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0018277,GO:0019538,GO:0019899,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051723,GO:0052689,GO:0070988,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1990827	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko02022,ko02035				Escherichia	1MWCN@1224,1RN67@1236,3XNVQ@561,COG2201@1,COG2201@2	NA|NA|NA	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR
b1884	316407.1736537	1.3e-162	578.9	Escherichia	cheR	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006479,GO:0006807,GO:0008022,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0008983,GO:0009987,GO:0010340,GO:0016020,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0032991,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051998,GO:0071704,GO:0071944,GO:0098561,GO:0140096,GO:1901564	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko01000,ko02035				Escherichia	1MU6W@1224,1RMFK@1236,3XN86@561,COG1352@1,COG1352@2	NA|NA|NA	J	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
b1885	316407.1736538	1.7e-221	775.4	Escherichia	tap	GO:0003674,GO:0004888,GO:0005575,GO:0005623,GO:0005886,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0009605,GO:0009987,GO:0016020,GO:0023052,GO:0038023,GO:0040011,GO:0042221,GO:0042330,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071944		ko:K05877	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Escherichia	1MU9B@1224,1RMH0@1236,3XNE9@561,COG0840@1,COG0840@2	NA|NA|NA	NT	Methyl-accepting chemotaxis protein
b1886	316407.1736539	2.3e-221	775.0	Escherichia	tar	GO:0001101,GO:0003674,GO:0004888,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006935,GO:0007154,GO:0007165,GO:0007172,GO:0008150,GO:0009593,GO:0009605,GO:0009719,GO:0009893,GO:0009966,GO:0009987,GO:0010033,GO:0010243,GO:0010604,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019222,GO:0019899,GO:0019900,GO:0019901,GO:0022607,GO:0023051,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032101,GO:0032268,GO:0032270,GO:0032991,GO:0034622,GO:0038023,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0042802,GO:0042803,GO:0043200,GO:0043424,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051606,GO:0051716,GO:0060089,GO:0060255,GO:0065003,GO:0065007,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071840,GO:0071944,GO:0080090,GO:0098561,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901873,GO:1901875		ko:K05875	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Escherichia	1MU9B@1224,1RMH0@1236,3XMD1@561,COG0840@1,COG0840@2	NA|NA|NA	NT	Methyl-accepting chemotaxis protein II
b1887	155864.EDL933_2862	1.5e-83	315.5	Escherichia	cheW	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0009605,GO:0009893,GO:0009987,GO:0010604,GO:0016020,GO:0019222,GO:0019904,GO:0023052,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032268,GO:0032270,GO:0032991,GO:0040011,GO:0042221,GO:0042330,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0098561,GO:1901873,GO:1901875		ko:K03408	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Escherichia	1RD1W@1224,1S26J@1236,3XNC7@561,COG0835@1,COG0835@2	NA|NA|NA	NT	Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges CheA to the MCPs (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to CheY and CheB
b1888	316407.1736547	0.0	1231.5	Escherichia	cheA	GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009892,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010605,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019220,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0032101,GO:0032268,GO:0032269,GO:0032270,GO:0032879,GO:0032991,GO:0035303,GO:0035304,GO:0035306,GO:0035307,GO:0035556,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045937,GO:0046777,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051248,GO:0051270,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0098561,GO:0140096,GO:1901564,GO:1901873,GO:1901875,GO:1902021,GO:2000145	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035				Escherichia	1MUAG@1224,1RMS6@1236,3XM5T@561,COG0643@1,COG0643@2,COG2198@1,COG2198@2	NA|NA|NA	NT	Chemotaxis protein cheA
b1889	155864.EDL933_2864	1.4e-167	595.5	Escherichia	motB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009288,GO:0009425,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044425,GO:0044459,GO:0044461,GO:0044463,GO:0044464,GO:0071944,GO:0120100,GO:0120101		ko:K02557	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1			Escherichia	1MW1Y@1224,1RPQ9@1236,3XNZZ@561,COG1360@1,COG1360@2	NA|NA|NA	N	MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Probably a linker that fastens the torque- generating machinery to the cell wall. Overexpression of this protein with MotA improves motility in a yhjH disruption, (a c-di- GMP phosphodiesterase) suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein YcgR and the flagellar stator
b1890	316407.1736549	5.5e-153	547.0	Escherichia	motA	GO:0001539,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0008150,GO:0009288,GO:0009425,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044425,GO:0044459,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071944,GO:0071973,GO:0071978,GO:0097588,GO:0120100,GO:0120101		ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040				ko00000,ko00001,ko02000,ko02035	1.A.30.1			Escherichia	1MXK3@1224,1RNTF@1236,3XPC5@561,COG1291@1,COG1291@2	NA|NA|NA	N	transmembrane proton channel. Overexpression of MotA, with or without MotB, restores motility in a yhjH disruption, (a c-di-GMP phosphodiesterase) suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein YcgR and the flagellar stator
b1891	155864.EDL933_2866	1.5e-106	392.1	Escherichia	flhC	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051302,GO:0051782,GO:0065007,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K02402	ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040				ko00000,ko00001,ko02035				Escherichia	1N7I6@1224,1RNUP@1236,2DBG4@1,2Z927@2,3XMRH@561	NA|NA|NA	K	Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways
b1892	199310.c2308	1.2e-55	222.2	Escherichia	flhD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K02403	ko02020,ko02024,ko02026,ko02040,map02020,map02024,map02026,map02040				ko00000,ko00001,ko02035				Escherichia	1N25K@1224,1S6JK@1236,2AX91@1,31P80@2,3XPQG@561	NA|NA|NA	K	Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways
b1893	177439.DP0860	5.6e-94	350.1	Proteobacteria													Escherichia	1NHAK@1224,COG1662@1,COG1662@2	NA|NA|NA	L	cog cog1662
b1894	1035839.AFNK01000018_gene1622	9e-46	189.1	Gammaproteobacteria													Escherichia	1NP8S@1224,1SDQB@1236,COG3677@1,COG3677@2	NA|NA|NA	L	PFAM Insertion element protein
b1895	316407.1736554	6e-73	280.0	Escherichia	uspC	GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0006950,GO:0006970,GO:0007154,GO:0008150,GO:0009267,GO:0009314,GO:0009411,GO:0009416,GO:0009605,GO:0009628,GO:0009651,GO:0009987,GO:0009991,GO:0031667,GO:0031668,GO:0031669,GO:0032947,GO:0033554,GO:0034644,GO:0042594,GO:0050896,GO:0051716,GO:0071214,GO:0071478,GO:0071482,GO:0071496,GO:0104004		ko:K14064					ko00000				Escherichia	1N4C6@1224,1S41H@1236,3XPJE@561,COG0589@1,COG0589@2	NA|NA|NA	T	Required for resistance to DNA-damaging agents
b1896	316407.85675158	1.4e-278	964.9	Escherichia	otsA	GO:0003674,GO:0003824,GO:0003825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0006974,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034637,GO:0035251,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100		R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003		GT20	iECs_1301.ECs2604,iZ_1308.Z2949	Escherichia	1MUIY@1224,1RNG7@1236,3XPDP@561,COG0380@1,COG0380@2	NA|NA|NA	G	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
b1897	316407.1736556	7.4e-149	533.1	Escherichia	otsB	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100		R02778	RC00017	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495	Escherichia	1RGY2@1224,1RNIQ@1236,3XMM7@561,COG1877@1,COG1877@2	NA|NA|NA	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose
b4460	198214.SF1945	2.9e-155	554.7	Gammaproteobacteria													Escherichia	1MVN9@1224,1RPYE@1236,COG1172@1,COG1172@2	NA|NA|NA	G	Belongs to the binding-protein-dependent transport system permease family
b1900	199310.c2313	4.5e-288	996.5	Escherichia	araG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.6.3.17	ko:K10539	ko02010,map02010	M00213			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.2		iSSON_1240.SSON_1218	Escherichia	1MU22@1224,1RSMB@1236,3XMD4@561,COG1129@1,COG1129@2	NA|NA|NA	P	Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system
b1901	316407.1736559	3.6e-185	654.1	Escherichia	araF	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015399,GO:0015405,GO:0015407,GO:0015749,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042623,GO:0042626,GO:0043211,GO:0043492,GO:0044464,GO:0048029,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702		ko:K10537	ko02010,map02010	M00213			ko00000,ko00001,ko00002,ko02000	3.A.1.2.2		iECIAI39_1322.ECIAI39_1152,iECOK1_1307.ECOK1_2016,iECP_1309.ECP_1842,iECS88_1305.ECS88_1956,iECSE_1348.ECSE_2133,iLF82_1304.LF82_0110,iNRG857_1313.NRG857_09510,iUMN146_1321.UM146_07665	Escherichia	1MVDG@1224,1RMBR@1236,3XNEH@561,COG1879@1,COG1879@2	NA|NA|NA	G	L-arabinose-binding periplasmic protein
b1902	155864.EDL933_2875	9.6e-86	322.8	Escherichia	ftnB	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771		ko:K02255					ko00000				Escherichia	1RDH6@1224,1S4UV@1236,3XPDA@561,COG1528@1,COG1528@2	NA|NA|NA	P	Iron-storage protein
b4537	199310.c2316	4.1e-37	160.2	Escherichia	yecJ												Escherichia	1MZGJ@1224,1S9UW@1236,2CJJE@1,32SA5@2,3XPYA@561	NA|NA|NA	S	Protein of unknown function (DUF2766)
b4663	199310.c2318	1.3e-08	63.9	Gammaproteobacteria													Escherichia	1NQB4@1224,1SHVT@1236,2DTJI@1,33KNA@2	NA|NA|NA		
b1904	316407.85675159	2.1e-54	218.0	Escherichia	yecR												Escherichia	1N47Q@1224,1SA54@1236,2DX6P@1,32V2W@2,3XRGM@561	NA|NA|NA	S	YecR-like lipoprotein
b1905	1440052.EAKF1_ch4138c	1.2e-88	332.4	Escherichia	ftnA	GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008199,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033554,GO:0042221,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071241,GO:0071248,GO:0071281,GO:0097577,GO:0098771	1.16.3.2	ko:K02217					ko00000,ko01000				Escherichia	1R9ZC@1224,1RYVB@1236,3XPF1@561,COG1528@1,COG1528@2	NA|NA|NA	P	Iron-storage protein
b1906	316407.1736568	1e-37	162.2	Escherichia	yecH												Escherichia	1N09N@1224,1SA8V@1236,2E9BS@1,333JI@2,3XQ13@561	NA|NA|NA	S	Protein of unknown function (DUF2492)
b1907	198214.SF1953	1.8e-215	755.0	Gammaproteobacteria													Escherichia	1N35H@1224,1RNNC@1236,COG0814@1,COG0814@2	NA|NA|NA	E	amino acid
b1908	198214.SF1954	6e-128	463.4	Gammaproteobacteria													Escherichia	1R4KR@1224,1RRDM@1236,COG3012@1,COG3012@2,COG3318@1,COG3318@2	NA|NA|NA	C	Belongs to the UPF0149 family
b1912	1440052.EAKF1_ch4123	5e-96	357.1	Escherichia	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100		R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000			iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iZ_1308.Z3000,ic_1306.c2325	Escherichia	1RCZ7@1224,1S465@1236,3XM7U@561,COG0558@1,COG0558@2	NA|NA|NA	I	This protein catalyzes the committed step to the synthesis of the acidic phospholipids
b1913	155864.EDL933_2918	0.0	1211.1	Escherichia	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391		ko:K03703	ko03420,map03420				ko00000,ko00001,ko03400				Escherichia	1MV38@1224,1RNGV@1236,3XNGD@561,COG0322@1,COG0322@2	NA|NA|NA	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
b1914	198214.SF1957	2.8e-114	417.9	Gammaproteobacteria													Escherichia	1MWGM@1224,1RQ1J@1236,COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
b1915	1440052.EAKF1_ch4120c	1.9e-30	137.9	Escherichia	yecF												Escherichia	1N71V@1224,1SCS7@1236,2E5U3@1,330IE@2,3XPZQ@561	NA|NA|NA	S	Protein of unknown function (DUF2594)
b1916	316407.1736575	7.9e-134	483.0	Escherichia	sdiA	GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010564,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032465,GO:0032467,GO:0043254,GO:0044087,GO:0044089,GO:0045787,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051302,GO:0051726,GO:0051781,GO:0060255,GO:0065007,GO:0080090,GO:0090068,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K07782	ko02020,ko02024,ko02026,map02020,map02024,map02026				ko00000,ko00001,ko03000				Escherichia	1R4TP@1224,1RR98@1236,3XPEZ@561,COG2197@1,COG2197@2	NA|NA|NA	K	Activates cell division by specifically increasing transcription from one of the two promoters that lie immediately upstream of the ftsQAZ gene cluster. Activates ydiV expression in response to extracellular autoinducer AI-1 (Vibrio fischeri autoinducer oxoC6)
b1917	316407.1736576	9.1e-133	479.6	Escherichia	yecC	GO:0000099,GO:0000101,GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008144,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015184,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015811,GO:0015849,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0072349,GO:0097159,GO:0097367,GO:0098656,GO:1901265,GO:1901363,GO:1901682,GO:1902475,GO:1903825,GO:1905039		ko:K10010	ko02010,map02010	M00234			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.10,3.A.1.3.14			Escherichia	1MU9Q@1224,1RMX1@1236,3XMSB@561,COG1126@1,COG1126@2	NA|NA|NA	P	Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. The system can probably also transport L-cysteine, and it mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys). Probably responsible for energy coupling to the transport system
b1918	198214.SF1961	5.8e-115	420.2	Gammaproteobacteria													Escherichia	1QN80@1224,1RR3B@1236,COG0765@1,COG0765@2	NA|NA|NA	P	amino acid ABC transporter
b1919	316407.85675161	8.8e-184	649.4	Escherichia	dcyD	GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006791,GO:0006807,GO:0006950,GO:0007154,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0016054,GO:0016829,GO:0016846,GO:0016848,GO:0019148,GO:0019149,GO:0019447,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0042594,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046416,GO:0046438,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071496,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.4.1.15	ko:K05396	ko00270,map00270		R01874	RC00382	ko00000,ko00001,ko01000			iSFV_1184.SFV_1963,iSFxv_1172.SFxv_2191	Escherichia	1MVYF@1224,1RMYP@1236,3XND5@561,COG2515@1,COG2515@2	NA|NA|NA	E	Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine
b1920	199310.c2335	2.2e-145	521.5	Escherichia	fliY			ko:K02424	ko02010,map02010	M00234			ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.3.10,3.A.1.3.14			Escherichia	1MXME@1224,1RPQ4@1236,3XRF1@561,COG0834@1,COG0834@2	NA|NA|NA	ET	Ligated ion channel L-glutamate- and glycine-binding site
b1921	316407.1736580	1.5e-103	382.1	Escherichia	fliZ	GO:0000988,GO:0000989,GO:0001047,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032879,GO:0040012,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051270,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902021,GO:1903506,GO:2000145,GO:2001141		ko:K02425	ko02026,map02026				ko00000,ko00001,ko02035			iB21_1397.fliZ,iECD_1391.fliZ	Escherichia	1P3KM@1224,1RRB7@1236,2DBMG@1,2Z9YQ@2,3XMC2@561	NA|NA|NA	K	During the post-exponential growth phase transiently interferes with RpoS (sigma S) activity without affecting expression of RpoS itself. It is probably not an anti-sigma factor as its overexpression is detrimental in rapidly growing cells where there is almost no sigma S factor. There is a strong overlap between Crl-activated genes and FliZ-down-regulated genes. FliZ acts as a timing device for expression of the genes for the adhesive curli fimbriae by indirectly decreasing expression of the curli regulator CsgD
b1922	199310.c2337	9.4e-127	459.5	Escherichia	fliA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111				ko00000,ko00001,ko02035,ko03021				Escherichia	1MWEU@1224,1RMKJ@1236,3XMN3@561,COG1191@1,COG1191@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes
b1923	316407.1736591	2.2e-218	765.0	Escherichia	fliC	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464		ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134				ko00000,ko00001,ko02035				Escherichia	1MV1N@1224,1RN0Y@1236,3XMAA@561,COG1344@1,COG1344@2	NA|NA|NA	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
b1924	316407.85675162	3.7e-204	717.6	Escherichia	fliD	GO:0001539,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588		ko:K02407	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1MUVP@1224,1RS2S@1236,3XMUS@561,COG1345@1,COG1345@2	NA|NA|NA	N	morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
b1925	316407.1736593	2.9e-64	251.1	Escherichia	fliS	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588		ko:K02422	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1MZ3G@1224,1S8TQ@1236,3XPKU@561,COG1516@1,COG1516@2	NA|NA|NA	N	bacterial-type flagellum assembly
b1926	155864.EDL933_2934	7.2e-59	233.0	Escherichia	fliT	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588		ko:K02423	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1NC88@1224,1SCME@1236,2DNZ7@1,32ZV7@2,3XPTB@561	NA|NA|NA	K	it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus
b1927	316407.1736595	3.6e-306	1056.6	Escherichia	amyA	GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016160,GO:0016787,GO:0016798,GO:0044424,GO:0044464	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973		R02108,R02112,R11262		ko00000,ko00001,ko01000		GH13	iECH74115_1262.ECH74115_2702,iECSP_1301.ECSP_2532,iECs_1301.ECs2666,iG2583_1286.G2583_2378,iSF_1195.SF1970	Escherichia	1MX9V@1224,1RP7Z@1236,3XN4K@561,COG0366@1,COG0366@2	NA|NA|NA	G	alpha-amylase activity
b1928	316407.1736596	2.6e-73	281.2	Escherichia	yedD												Escherichia	1RDMY@1224,1S41Z@1236,2C08M@1,2ZQUD@2,3XPN0@561	NA|NA|NA	M	YedD-like protein
b1929	316407.1736597	6e-235	819.7	Escherichia	yedE	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K07112					ko00000				Escherichia	1PF9B@1224,1RNE8@1236,3XN3Y@561,COG2391@1,COG2391@2	NA|NA|NA	S	Sulphur transport
b1930	1080067.BAZH01000024_gene3535	1.2e-38	165.2	Citrobacter													Escherichia	1N0EX@1224,1S9V5@1236,3WYUJ@544,COG0425@1,COG0425@2	NA|NA|NA	O	Sulfurtransferase TusA
b1931	316407.85675163	2e-131	474.9	Escherichia	yedK												Escherichia	1RER4@1224,1RSBH@1236,3XMZS@561,COG2135@1,COG2135@2	NA|NA|NA	E	Belongs to the SOS response-associated peptidase family
b1932	316407.85675164	3.9e-89	334.0	Gammaproteobacteria													Escherichia	1QUHE@1224,1T1Z5@1236,COG0454@1,COG0454@2	NA|NA|NA	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
b4495	155864.EDL933_2941	6e-37	161.8	Gammaproteobacteria													Escherichia	1NF73@1224,1RXVA@1236,COG4886@1,COG4886@2	NA|NA|NA	S	COG4886 Leucine-rich repeat (LRR) protein
b1936	640513.Entas_2732	3.9e-12	77.4	Enterobacter													Escherichia	1MVZB@1224,1RP4Y@1236,3X3BM@547,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
b1937	155864.EDL933_2944	6e-46	189.9	Escherichia	fliE			ko:K02408	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1N6RZ@1224,1SD52@1236,3XPVX@561,COG1677@1,COG1677@2	NA|NA|NA	N	Flagellar hook-basal body complex protein FliE
b1938	316407.1736604	3.6e-291	1006.9	Escherichia	fliF			ko:K02409	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Escherichia	1MUQR@1224,1RN6T@1236,3XNC5@561,COG1766@1,COG1766@2	NA|NA|NA	N	The M ring may be actively involved in energy transduction
b1939	155864.EDL933_2947	2.4e-173	614.8	Escherichia	fliG	GO:0001539,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006928,GO:0006996,GO:0008150,GO:0009288,GO:0009425,GO:0009987,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0040011,GO:0042802,GO:0042995,GO:0043226,GO:0043228,GO:0044085,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0044780,GO:0044781,GO:0048870,GO:0051179,GO:0051674,GO:0070925,GO:0071840,GO:0071944,GO:0071973,GO:0097588		ko:K02410	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035				Escherichia	1MV9X@1224,1RM9B@1236,3XMFG@561,COG1536@1,COG1536@2	NA|NA|NA	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
b1940	316407.1736606	1.3e-90	339.3	Escherichia	fliH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02411	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2			Escherichia	1NMQE@1224,1RR8H@1236,3XMIR@561,COG1317@1,COG1317@2	NA|NA|NA	N	Flagellar assembly protein fliH
b1941	155864.EDL933_2949	2.4e-256	891.0	Escherichia	fliI	GO:0003674,GO:0005488,GO:0005515,GO:0042802	3.6.3.14	ko:K02412	ko02040,map02040				ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3			Escherichia	1MUH6@1224,1RM9W@1236,3XN8K@561,COG1157@1,COG1157@2	NA|NA|NA	NU	catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage
b1942	316407.1736608	1.6e-73	282.0	Escherichia	fliJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02413	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1RHFM@1224,1S76M@1236,3XPK5@561,COG2882@1,COG2882@2	NA|NA|NA	N	Flagellar protein that affects chemotactic events
b1943	316407.1736609	1.6e-189	668.7	Escherichia	fliK	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588		ko:K02414	ko02040,map02040				ko00000,ko00001,ko02035				Escherichia	1N7XT@1224,1SCA6@1236,3XNRK@561,COG3144@1,COG3144@2	NA|NA|NA	N	Flagellar hook-length control protein
b1944	155864.EDL933_2952	2.7e-79	301.2	Escherichia	fliL	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588		ko:K02415					ko00000,ko02035				Escherichia	1RARK@1224,1S2F1@1236,3XMI3@561,COG1580@1,COG1580@2	NA|NA|NA	N	Controls the rotational direction of flagella during chemotaxis
b1945	316407.1736611	4.1e-189	667.2	Escherichia	fliM	GO:0005575,GO:0005623,GO:0005886,GO:0006935,GO:0008150,GO:0009288,GO:0009425,GO:0009605,GO:0016020,GO:0040011,GO:0042221,GO:0042330,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0050896,GO:0050918,GO:0071944		ko:K02416	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035				Escherichia	1MX01@1224,1RQ8M@1236,3XNNG@561,COG1868@1,COG1868@2	NA|NA|NA	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
b1946	316407.1736612	4.8e-67	260.4	Escherichia	fliN	GO:0005575,GO:0005623,GO:0005886,GO:0009288,GO:0009425,GO:0016020,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0071944		ko:K02417	ko02030,ko02040,map02030,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3			Escherichia	1RGWT@1224,1S5YE@1236,3XPJF@561,COG1886@1,COG1886@2	NA|NA|NA	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
b1947	155864.EDL933_2955	5.7e-56	223.4	Escherichia	fliO			ko:K02418	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2			Escherichia	1N79Z@1224,1SCKP@1236,3XPVU@561,COG3190@1,COG3190@2	NA|NA|NA	N	bacterial-type flagellum organization
b1948	155864.EDL933_2956	1.4e-125	455.7	Escherichia	fliP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02419	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2			Escherichia	1MVBU@1224,1RMYH@1236,3XM6F@561,COG1338@1,COG1338@2	NA|NA|NA	N	Plays a role in the flagellum-specific transport system
b1949	155864.EDL933_2957	6.3e-36	156.4	Escherichia	fliQ			ko:K02420	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2			Escherichia	1N73W@1224,1SCBG@1236,3XPW6@561,COG1987@1,COG1987@2	NA|NA|NA	N	Flagellar biosynthetic protein FliQ
b1950	316407.1736616	6.8e-131	473.4	Escherichia	fliR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02421	ko02040,map02040				ko00000,ko00001,ko02035,ko02044	3.A.6.2			Escherichia	1NIF4@1224,1RMYW@1236,3XN5S@561,COG1684@1,COG1684@2	NA|NA|NA	N	Role in flagellar biosynthesis
b1951	155864.EDL933_2959	5.8e-109	400.2	Escherichia	rcsA	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K07781	ko02020,ko02024,ko02026,map02020,map02024,map02026				ko00000,ko00001,ko03000				Escherichia	1MWHX@1224,1RRK0@1236,3XP1K@561,COG2197@1,COG2197@2	NA|NA|NA	K	Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes
b1952	1440052.EAKF1_ch4087	4e-29	133.3	Escherichia	dsrB												Escherichia	1N7NE@1224,1SD23@1236,2E52Z@1,32ZW5@2,3XQ2F@561	NA|NA|NA	S	Belongs to the DsrB family
b1953	155864.EDL933_2961	1.9e-33	147.9	Escherichia	yodD	GO:0000302,GO:0006950,GO:0006979,GO:0008150,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010447,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044011,GO:0044764,GO:0046677,GO:0050896,GO:0051703,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0090605,GO:0090609,GO:0097237,GO:0104004,GO:1901700,GO:1901701											Escherichia	1NC7W@1224,1SBI7@1236,2E0QC@1,32W92@2,3XQ40@561	NA|NA|NA	S	cellular response to acidic pH
b1955	316407.85675168	5.8e-157	560.1	Escherichia	yedP		3.1.3.70	ko:K07026	ko00051,map00051		R05790	RC00017	ko00000,ko00001,ko01000				Escherichia	1NFV5@1224,1RR9R@1236,3XM3H@561,COG3769@1,COG3769@2	NA|NA|NA	S	glycoside biosynthetic process
b1956	316407.1736626	0.0	1120.5	Escherichia	yedQ	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0032879,GO:0040012,GO:0040013,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0052621,GO:0065007,GO:0071944,GO:1902021,GO:1902201,GO:2000145,GO:2000146	2.7.7.65	ko:K21085	ko02026,map02026				ko00000,ko00001,ko01000			iLF82_1304.LF82_2957,iSbBS512_1146.SbBS512_E1077	Escherichia	1MZV7@1224,1RSJI@1236,3XN3P@561,COG2199@1,COG3706@2	NA|NA|NA	T	in the regulation of cellulose production
b1957	155864.EDL933_2965	4.7e-27	126.3	Escherichia	yodC												Escherichia	1N81T@1224,1SD0R@1236,3XQ38@561,COG5475@1,COG5475@2	NA|NA|NA	S	Uncharacterized small protein (DUF2158)
b1958	316407.1736627	6.3e-152	543.5	Escherichia	yedI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K09781					ko00000				Escherichia	1MVYU@1224,1RMUZ@1236,3XMZD@561,COG2354@1,COG2354@2	NA|NA|NA	S	Protein of unknown function (DUF808)
b1959	155864.EDL933_2967	1.6e-158	565.5	Escherichia	yedA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944											Escherichia	1MXX1@1224,1RPRZ@1236,3XMGK@561,COG0697@1,COG0697@2	NA|NA|NA	EG	inner membrane transporter YedA
b1960	316407.1736629	1.6e-87	328.6	Escherichia	vsr	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0043170,GO:0043765,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363		ko:K07458					ko00000,ko01000,ko03400			iB21_1397.ECBD_1686,iECD_1391.ECBD_1686	Escherichia	1RH1C@1224,1S2V3@1236,3XME9@561,COG3727@1,COG3727@2	NA|NA|NA	L	May nick specific sequences that contain T G mispairs resulting from m5C-deamination
b1961	155864.EDL933_2969	4.2e-280	969.9	Escherichia	dcm	GO:0003674,GO:0003824,GO:0003886,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0032776,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044728,GO:0046483,GO:0071704,GO:0090116,GO:0090304,GO:0140097,GO:1901360	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036				Escherichia	1MV9H@1224,1RPM4@1236,3XPAF@561,COG0270@1,COG0270@2	NA|NA|NA	L	This methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands
b1962	316407.1736632	9e-127	459.5	Escherichia	yedJ			ko:K06950					ko00000				Escherichia	1RB2W@1224,1RR38@1236,3XM7Y@561,COG1418@1,COG1418@2	NA|NA|NA	S	Metal dependent phosphohydrolases with conserved 'HD' motif.
b1963	481805.EcolC_1680	2.7e-66	257.7	Escherichia	yedR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1N08R@1224,1SA7X@1236,2DZQZ@1,32VGN@2,3XPU8@561	NA|NA|NA		
b4496	502347.ESCAB7627_3518	2.7e-99	369.0	Escherichia													Escherichia	1MVRY@1224,1RNBS@1236,3XN4M@561,COG3203@1,COG3203@2	NA|NA|NA	M	Outer membrane protein N
b1967	316407.85675171	7.1e-166	589.7	Escherichia	hchA	GO:0003674,GO:0003700,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0006139,GO:0006259,GO:0006281,GO:0006355,GO:0006464,GO:0006517,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009100,GO:0009268,GO:0009438,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010447,GO:0010468,GO:0010556,GO:0016053,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019219,GO:0019222,GO:0019243,GO:0019249,GO:0019538,GO:0019752,GO:0030091,GO:0031323,GO:0031326,GO:0032787,GO:0033554,GO:0034641,GO:0036211,GO:0036524,GO:0036525,GO:0042180,GO:0042182,GO:0042221,GO:0042245,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046394,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051595,GO:0051596,GO:0051716,GO:0060255,GO:0061727,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1901654,GO:1901700,GO:1903506,GO:2000112,GO:2001141	3.5.1.124,4.2.1.130	ko:K05523	ko00620,ko01120,map00620,map01120		R09796	RC02658	ko00000,ko00001,ko01000,ko01002				Escherichia	1R41H@1224,1RR9T@1236,3XNHU@561,COG0693@1,COG0693@2	NA|NA|NA	J	Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Plays an important role in protecting cells from carbonyl stress
b1968	316407.1736637	1.4e-248	865.1	Escherichia	yedV	GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0033554,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K02484					ko00000,ko01000,ko01001,ko02022				Escherichia	1MW8M@1224,1RNDA@1236,3XMWP@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
b1969	316407.85675172	3.2e-121	441.0	Escherichia	yedW	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K02483					ko00000,ko02022				Escherichia	1MU67@1224,1RNWH@1236,3XPAK@561,COG0745@1,COG0745@2	NA|NA|NA	K	transcriptional regulatory protein YedW
b1970	316407.85675173	1.9e-71	275.0	Escherichia	hiuH	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0033971,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564	3.5.2.17	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601	RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2			Escherichia	1RH84@1224,1S6D3@1236,3XPTZ@561,COG2351@1,COG2351@2	NA|NA|NA	F	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily
b1971	316407.85675174	3.7e-198	697.2	Escherichia	msrP	GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0016672,GO:0016675,GO:0019538,GO:0030091,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0043546,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0055114,GO:0071704,GO:0097159,GO:1901363,GO:1901530,GO:1901564,GO:1901700		ko:K07147					ko00000,ko01000				Escherichia	1MUW0@1224,1RQ2J@1236,3XN0Z@561,COG2041@1,COG2041@2	NA|NA|NA	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
b1972	316407.85675175	4e-113	414.1	Escherichia	msrQ	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010181,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019538,GO:0020037,GO:0030091,GO:0031224,GO:0031226,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564		ko:K17247					ko00000				Escherichia	1RDUP@1224,1RS9K@1236,3XMFR@561,COG2717@1,COG2717@2	NA|NA|NA	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
b1973	316407.85675176	4.3e-123	447.2	Escherichia	zinT	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0007154,GO:0008150,GO:0008270,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0030288,GO:0030313,GO:0031667,GO:0031668,GO:0031669,GO:0031975,GO:0033554,GO:0034224,GO:0042221,GO:0042594,GO:0042597,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046686,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0120127											Escherichia	1MXFK@1224,1RPWU@1236,3XN2U@561,COG3443@1,COG3443@2	NA|NA|NA	S	May function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions. Binds zinc with high affinity, and can also bind cadmium, mercury or nickel. Preferentially binds Zn(2 ) over Cd(2 ). Contains one high affinity metal binding site, and can bind additional metal ions at other sites
b1974	316407.85675177	1.1e-97	362.5	Escherichia	yodB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RBP8@1224,1S563@1236,3XRMF@561,COG3038@1,COG3038@2	NA|NA|NA	C	respiratory electron transport chain
b1976	155864.EDL933_3048	5.8e-154	550.1	Escherichia	mtfA	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006508,GO:0006807,GO:0008134,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0043170,GO:0043433,GO:0044092,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141		ko:K09933					ko00000,ko01002				Escherichia	1RAHF@1224,1RZQU@1236,3XMFJ@561,COG3228@1,COG3228@2	NA|NA|NA	S	Involved in the regulation of ptsG expression by binding and inactivating Mlc
b1978	316407.85675179	0.0	4468.7	Escherichia	yeeJ	GO:0007155,GO:0008150,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0044764,GO:0051704,GO:0090605		ko:K13735	ko05100,map05100				ko00000,ko00001				Escherichia	1MX9S@1224,1RPK7@1236,3XN7T@561,COG1388@1,COG1388@2,COG1470@1,COG1470@2	NA|NA|NA	M	cell adhesion
b4497	155864.EDL933_3050	9.3e-184	649.4	Gammaproteobacteria													Escherichia	1R66F@1224,1S0J4@1236,COG0859@1,COG0859@2	NA|NA|NA	M	Glycosyltransferase family 9 (heptosyltransferase)
b1981	316407.1736645	2.4e-245	854.4	Escherichia	shiA	GO:0000271,GO:0003674,GO:0003824,GO:0005215,GO:0005342,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006810,GO:0006811,GO:0006820,GO:0008028,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0015075,GO:0015318,GO:0015530,GO:0015711,GO:0015718,GO:0015733,GO:0015849,GO:0015850,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0022857,GO:0033692,GO:0034220,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071944,GO:0098656,GO:1901135,GO:1901137,GO:1901576,GO:1901618,GO:1903509,GO:1903825,GO:1905039		ko:K08172					ko00000,ko02000	2.A.1.6.6		iAPECO1_1312.APECO1_1067,iEC55989_1330.EC55989_2218,iECNA114_1301.ECNA114_2055,iECS88_1305.ECS88_2049,iLF82_1304.LF82_2131,iNRG857_1313.NRG857_09945	Escherichia	1MU46@1224,1RMF0@1236,3XNBS@561,COG0477@1,COG0477@2	NA|NA|NA	P	Shikimate transporter
b1982	155864.EDL933_3052	8.7e-289	998.8	Escherichia	amn	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008714,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464	3.2.2.4	ko:K01241	ko00230,map00230		R00182	RC00063,RC00318	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c22520,iECOK1_1307.ECOK1_2159,iECP_1309.ECP_1955,iETEC_1333.ETEC_2095,iNRG857_1313.NRG857_09950,iUMN146_1321.UM146_07225,ic_1306.c2444	Escherichia	1MUMQ@1224,1RNZ4@1236,3XP6V@561,COG0775@1,COG0775@2	NA|NA|NA	F	Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations
b1983	199310.c2445	2.5e-127	461.5	Escherichia	yeeN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MW3X@1224,1RP5N@1236,3XQQV@561,COG0217@1,COG0217@2	NA|NA|NA	K	transcriptional regulatory protein YeeN
b1985	316407.85675181	2.3e-309	1067.4	Escherichia	yeeO	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006857,GO:0006862,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015215,GO:0015230,GO:0015605,GO:0015711,GO:0015748,GO:0015833,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0034220,GO:0035350,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0044610,GO:0051179,GO:0051181,GO:0051182,GO:0051184,GO:0051185,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098656,GO:1901264,GO:1901505,GO:1901679,GO:1904680											Escherichia	1MVRV@1224,1RNQ7@1236,3XMYX@561,COG0534@1,COG0534@2	NA|NA|NA	U	A transporter able to export peptides and flavins. When overexpressed allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide, overproduction of this protein increases its export. When overexpressed increases secretion of FMN and FAD but not riboflavin
b1987	316407.1736649	1.9e-175	621.7	Escherichia	cbl	GO:0006792,GO:0008150,GO:0045883,GO:0048518,GO:0050789,GO:0065007		ko:K13635					ko00000,ko03000				Escherichia	1MU8N@1224,1RN7T@1236,3XM98@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
b1988	316407.1736650	5.9e-158	563.5	Escherichia	nac	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K19338					ko00000,ko03000				Escherichia	1MXR1@1224,1RPF3@1236,3XM4K@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity)
b1990	316407.1736651	4e-178	630.6	Escherichia	erfK	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0008236,GO:0008238,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0016807,GO:0017171,GO:0018104,GO:0019538,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0070004,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071972,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576		ko:K16291					ko00000,ko01002,ko01011				Escherichia	1P95A@1224,1RME2@1236,3XMNG@561,COG1376@1,COG1376@2	NA|NA|NA	M	Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L- Lys- bond on the terminal residue of Lpp
b1991	316407.1736652	2.2e-196	691.4	Escherichia	cobT	GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_2242,iSF_1195.SF2059,iSFxv_1172.SFxv_2293,iS_1188.S2169	Escherichia	1MVAM@1224,1RNPV@1236,3XNPP@561,COG2038@1,COG2038@2	NA|NA|NA	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
b1992	316407.1736653	3e-128	464.5	Escherichia	cobS	GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016020,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_2837,iECO103_1326.ECO103_2453,iECSP_1301.ECSP_2657,iECs_1301.ECs2787,iG2583_1286.G2583_2502,iUTI89_1310.UTI89_C2230,iZ_1308.Z3152,ic_1306.c2478	Escherichia	1RHCC@1224,1S4TE@1236,3XN3V@561,COG0368@1,COG0368@2	NA|NA|NA	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
b1993	155864.EDL933_3064	1.4e-98	365.5	Escherichia	cobU	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008819,GO:0008820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0033554,GO:0044237,GO:0050896,GO:0051716,GO:0070568	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_2074,iECSE_1348.ECSE_2277,iECW_1372.ECW_m2165,iETEC_1333.ETEC_2103,iEcE24377_1341.EcE24377A_2275,iEcSMS35_1347.EcSMS35_1131,iEcolC_1368.EcolC_1635,iLF82_1304.LF82_0337,iSDY_1059.SDY_2240,iWFL_1372.ECW_m2165	Escherichia	1RH0A@1224,1S42M@1236,3XPK4@561,COG2087@1,COG2087@2	NA|NA|NA	H	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
b1994	316407.1736655	4.3e-194	683.7	Gammaproteobacteria													Escherichia	1MVDK@1224,1RR0T@1236,COG3039@1,COG3039@2	NA|NA|NA	L	COG3039 Transposase and inactivated derivatives IS5 family
b4582	155864.EDL933_3069	1.3e-45	188.7	Escherichia				ko:K16087					ko00000,ko02000	1.B.14.2			Escherichia	1MUC1@1224,1S0MR@1236,3XRI6@561,COG1629@1,COG4771@2	NA|NA|NA	P	Outer membrane protein beta-barrel family
b1996	316407.2447044	3.9e-178	630.6	Gammaproteobacteria													Escherichia	1MY62@1224,1RQSR@1236,COG2801@1,COG2801@2	NA|NA|NA	L	cog cog2801
b1997	1440052.EAKF1_ch0283	7.2e-59	233.0	Escherichia													Escherichia	1N0V0@1224,1S7WV@1236,3XRHH@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
b1999	637910.ROD_49751	5.1e-72	276.9	Citrobacter													Escherichia	1NG19@1224,1RPV6@1236,3WWDF@544,COG3596@1,COG3596@2	NA|NA|NA	S	50S ribosome-binding GTPase
b2000	316407.85675183	0.0	1358.6	Gammaproteobacteria													Escherichia	1QNFZ@1224,1RR10@1236,COG3468@1,COG3468@2	NA|NA|NA	MU	Adhesin of bacterial autotransporter system, probable stalk
b2001	316407.85675184	2.7e-296	1023.8	Bacteria													Escherichia	COG2020@1,COG2020@2	NA|NA|NA	O	methyltransferase activity
b2002	316407.1736671	3.8e-78	297.4	Escherichia	yeeS			ko:K03630					ko00000				Escherichia	1MW2D@1224,1S0RG@1236,3XQMM@561,COG2003@1,COG2003@2	NA|NA|NA	E	Belongs to the UPF0758 family
b2003	155864.EDL933_3073	1.4e-36	158.3	Escherichia	yeeT												Escherichia	1N89D@1224,1SFG4@1236,2CZYD@1,333DH@2,3XR4B@561	NA|NA|NA	S	Escherichia coli O157 H7 ortholog
b2004	199310.c2531	1e-65	255.8	Gammaproteobacteria													Escherichia	1RI9Y@1224,1S8EC@1236,2BMAS@1,32FUR@2	NA|NA|NA	S	CbeA_antitoxin, type IV, cytoskeleton bundling-enhancing factor A
b2005	199310.c2532	6.9e-65	253.1	Gammaproteobacteria													Escherichia	1REKF@1224,1S4ED@1236,2C4I5@1,30KUQ@2	NA|NA|NA	S	inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization. Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization. Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation
b2006	199310.c4577	4.1e-21	106.7	Gammaproteobacteria													Escherichia	1N76M@1224,1SFFA@1236,2C6P3@1,32ZZF@2	NA|NA|NA	S	Enterobacterial protein of unknown function (DUF957)
b4538	316407.85675188	2.1e-63	248.1	Escherichia	yoeF			ko:K04029					ko00000				Escherichia	1RIVR@1224,1S3XX@1236,3XQ3H@561,COG4917@1,COG4917@2	NA|NA|NA	E	Ethanolamine utilisation - propanediol utilisation
b2007	155864.EDL933_3079	6.5e-51	206.5	Escherichia	yeeX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09802					ko00000				Escherichia	1RH0U@1224,1S6XT@1236,3XPNT@561,COG2926@1,COG2926@2	NA|NA|NA	S	Belongs to the UPF0265 family
b2008	316407.1736674	4.3e-197	693.7	Escherichia	yeeA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MUWE@1224,1RNFT@1236,3XM9R@561,COG1289@1,COG1289@2	NA|NA|NA	S	transmembrane transporter activity
b2009	316407.1736675	7.1e-91	339.7	Escherichia	sbmC	GO:0003674,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006275,GO:0006950,GO:0006974,GO:0008150,GO:0008156,GO:0008657,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0010911,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032780,GO:0033554,GO:0042030,GO:0043086,GO:0043462,GO:0044092,GO:0044424,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051336,GO:0051346,GO:0051716,GO:0060255,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0080090,GO:0090329,GO:0098772,GO:2000104,GO:2000112,GO:2000113,GO:2000371,GO:2000372		ko:K07470					ko00000				Escherichia	1RG5K@1224,1S4HI@1236,3XMF6@561,COG3449@1,COG3449@2	NA|NA|NA	L	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
b2010	316407.85675189	2.6e-227	794.3	Escherichia	dacD	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008360,GO:0008658,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016787,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100				ko00000,ko00001,ko01000,ko01002,ko01011			iEC55989_1330.EC55989_2269	Escherichia	1MUU7@1224,1RMJA@1236,3XP01@561,COG1686@1,COG1686@2	NA|NA|NA	M	Belongs to the peptidase S11 family
b2011	316407.1736685	8.8e-286	988.8	Escherichia	sbcB	GO:0000175,GO:0000287,GO:0000738,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008852,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016829,GO:0016835,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0046872,GO:0051575,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575	3.1.11.1	ko:K01141	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Escherichia	1MV0U@1224,1RM85@1236,3XMEP@561,COG2925@1,COG2925@2	NA|NA|NA	L	Degrades single-stranded DNA (ssDNA) in a highly processive manner. Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic apyrimidinic (AP) site by either an AP endonuclease or AP lyase
b2012	316407.1736686	2.2e-34	151.0	Gammaproteobacteria													Escherichia	1N4X7@1224,1SCWW@1236,COG0425@1,COG0425@2	NA|NA|NA	O	Sulfurtransferase TusA
b2013	316407.1736687	2e-194	684.9	Gammaproteobacteria													Escherichia	1MWWP@1224,1RR58@1236,COG2391@1,COG2391@2	NA|NA|NA	S	Inner membrane protein PRK11099
b2014	155864.EDL933_3087	1.5e-250	871.7	Escherichia	plaP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006928,GO:0008150,GO:0008324,GO:0008519,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015101,GO:0015203,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015489,GO:0015672,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0040011,GO:0044464,GO:0048870,GO:0051179,GO:0051234,GO:0051674,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655,GO:0098660,GO:0098662,GO:1902047,GO:1902600											Escherichia	1MXNJ@1224,1RMKV@1236,3XN4G@561,COG0531@1,COG0531@2	NA|NA|NA	E	putrescine transmembrane transporter activity
b2015	316407.85675191	2.3e-173	614.8	Escherichia	yeeY	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1MZTA@1224,1RQT0@1236,3XN23@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
b2016	155864.EDL933_3090	1.2e-157	562.4	Escherichia	yeeZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MWVJ@1224,1RNDT@1236,3XMI9@561,COG0451@1,COG0451@2	NA|NA|NA	GM	coenzyme binding
b4539	198214.SF2076	1.7e-43	181.4	Gammaproteobacteria													Escherichia	1MZBP@1224,1S99Z@1236,COG4115@1,COG4115@2	NA|NA|NA	S	Addiction module toxin, Txe YoeB
b2017	198214.SF2079	2.4e-37	161.0	Gammaproteobacteria													Escherichia	1N6X6@1224,1SDQ0@1236,COG2161@1,COG2161@2	NA|NA|NA	D	Antitoxin component of a toxin-antitoxin (TA) module
b2019	199310.c2546	1.8e-164	585.1	Escherichia	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000			iECSF_1327.ECSF_1909	Escherichia	1MUCY@1224,1RNAX@1236,3XNIV@561,COG0040@1,COG0040@2	NA|NA|NA	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
b2020	316407.85675196	6.5e-235	819.7	Escherichia	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_2362,iG2583_1286.G2583_2541,iUTI89_1310.UTI89_C2293,ic_1306.c2547	Escherichia	1MUUF@1224,1RMZD@1236,3XMXY@561,COG0141@1,COG0141@2	NA|NA|NA	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
b2021	316407.1736699	5.9e-202	709.9	Escherichia	hisC	GO:0000105,GO:0003674,GO:0003824,GO:0004400,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007			iSDY_1059.SDY_2220,iSSON_1240.SSON_2092	Escherichia	1MW7I@1224,1RP4T@1236,3XN8C@561,COG0079@1,COG0079@2	NA|NA|NA	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
b2022	316407.1736700	3.5e-210	737.3	Escherichia	hisB	GO:0003674,GO:0003824,GO:0004401,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0042802,GO:0044237	3.1.3.15,4.2.1.19	ko:K01089	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000			iECS88_1305.ECS88_2121,iUMNK88_1353.UMNK88_2570	Escherichia	1MWBS@1224,1RPA9@1236,3XMA4@561,COG0131@1,COG0131@2,COG0241@1,COG0241@2	NA|NA|NA	E	Histidine biosynthesis bifunctional protein HisB
b2023	199310.c2550	1.4e-112	412.1	Escherichia	hisH	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234		ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_2372	Escherichia	1MU4X@1224,1RRP3@1236,3XNQK@561,COG0118@1,COG0118@2	NA|NA|NA	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
b2024	316407.1736702	9.6e-135	486.1	Escherichia	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0033554,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0050896,GO:0051716,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000			iSBO_1134.SBO_0850,iSDY_1059.SDY_2217	Escherichia	1MW6S@1224,1RN3M@1236,3XNGK@561,COG0106@1,COG0106@2	NA|NA|NA	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
b2025	155864.EDL933_3097	3.7e-145	520.8	Escherichia	hisF	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234		ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000			iEcolC_1368.EcolC_1617	Escherichia	1MUS0@1224,1RPJQ@1236,3XNNT@561,COG0107@1,COG0107@2	NA|NA|NA	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
b2026	316407.1736705	7.2e-112	409.8	Escherichia	hisI	GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31	ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186	Escherichia	1MW67@1224,1RMV4@1236,3XNZI@561,COG0139@1,COG0139@2,COG0140@1,COG0140@2	NA|NA|NA	F	Histidine biosynthesis bifunctional protein HisIE
b2027	316407.1736706	1.4e-173	615.5	Escherichia	wzzB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K05789					ko00000,ko01005				Escherichia	1MVM1@1224,1RNAU@1236,3XPAY@561,COG3765@1,COG3765@2	NA|NA|NA	M	Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules
b2028	316407.85675197	4.2e-217	760.4	Escherichia	ugd	GO:0000271,GO:0003674,GO:0003824,GO:0003979,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046377,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_2287	Escherichia	1MW5U@1224,1RMVW@1236,3XMFE@561,COG1004@1,COG1004@2	NA|NA|NA	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
b2029	316407.1736717	2.6e-266	924.1	Escherichia	gnd	GO:0003674,GO:0003824,GO:0004616,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019362,GO:0019520,GO:0019521,GO:0019637,GO:0019682,GO:0019693,GO:0019752,GO:0032787,GO:0034641,GO:0042802,GO:0042803,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046176,GO:0046177,GO:0046395,GO:0046483,GO:0046496,GO:0046983,GO:0051156,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072329,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000			iECW_1372.ECW_m2189,iEKO11_1354.EKO11_1765,iWFL_1372.ECW_m2189	Escherichia	1MVV8@1224,1RM7P@1236,3XN7J@561,COG0362@1,COG0362@2	NA|NA|NA	F	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
b2030	316407.1736552	5.6e-194	683.3	Gammaproteobacteria													Escherichia	1MVDK@1224,1RR0T@1236,COG3039@1,COG3039@2	NA|NA|NA	L	COG3039 Transposase and inactivated derivatives IS5 family
b2032	316407.1736722	1.4e-214	751.9	Gammaproteobacteria													Escherichia	1RASH@1224,1S3DI@1236,COG0438@1,COG0438@2	NA|NA|NA	M	May be a glycosyltransferase involved in the transfer of UDP-GalF and UDP-glucose
b2033	316407.1736723	1.5e-106	392.1	Gammaproteobacteria													Escherichia	1N6SQ@1224,1SB21@1236,COG0110@1,COG0110@2	NA|NA|NA	S	lipopolysaccharide biosynthesis O-acetyl transferase
b2034	316407.1736724	8.8e-192	676.0	Gammaproteobacteria													Escherichia	1N2ZZ@1224,1S92B@1236,COG0438@1,COG0438@2	NA|NA|NA	M	Involved in the transfer of galactofuranose (Galf) onto an alpha-D-gluco-configured acceptor substrate to form a beta-1,6- linkage. It uses n-octyl alpha-D-glucopyranoside as an acceptor substrate for the addition of galactofuranose from the donor substrate UDP-galactofuranose. It is not able to use beta-D- glucopyranoside isomers
b2035	316407.1736725	2.5e-206	724.5	Bacteria													Escherichia	2DD48@1,2ZGEK@2	NA|NA|NA	A	May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS
b2036	316407.1736726	1.2e-218	765.4	Escherichia	glf	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008767,GO:0016853,GO:0016866,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0097159,GO:1901265,GO:1901363	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520		R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000				Escherichia	1MV4H@1224,1RPMY@1236,3XQDU@561,COG0562@1,COG0562@2	NA|NA|NA	J	Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF)
b2037	316407.1736727	1.2e-217	762.3	Gammaproteobacteria													Escherichia	1R9XE@1224,1S2YR@1236,COG2244@1,COG2244@2	NA|NA|NA	S	Polysaccharide biosynthesis protein
b2038	316407.1736728	2.1e-105	388.3	Escherichia	rfbC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008830,GO:0009058,GO:0009059,GO:0009103,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0046677,GO:0050896,GO:0051716,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000			iAF1260.b2038,iBWG_1329.BWG_1828,iECDH10B_1368.ECDH10B_2188,iECSF_1327.ECSF_1927,iJO1366.b2038,iJR904.b2038	Escherichia	1R9YD@1224,1S245@1236,3XR1G@561,COG1898@1,COG1898@2	NA|NA|NA	F	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
b2039	316407.1736729	3.5e-168	597.4	Escherichia	rfbA	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0046872,GO:0071704,GO:1901576	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_2206	Escherichia	1MU0X@1224,1RMTR@1236,3XMX5@561,COG1209@1,COG1209@2	NA|NA|NA	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
b2040	316407.1736730	4.1e-172	610.5	Escherichia	rfbD	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008831,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000			iECSF_1327.ECSF_1929	Escherichia	1MUXM@1224,1RSNR@1236,3XQ8Q@561,COG1091@1,COG1091@2	NA|NA|NA	F	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose
b2041	316407.1736731	6.4e-212	743.0	Escherichia	rfbB	GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006139,GO:0006629,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0046483,GO:0048037,GO:0050662,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576,GO:1903509	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_01936,iECBD_1354.ECBD_1614,iECB_1328.ECB_01947,iECD_1391.ECD_01947,iECIAI39_1322.ECIAI39_0974,iECO26_1355.ECO26_2952,iECSF_1327.ECSF_1930	Escherichia	1MU5E@1224,1RP7G@1236,3XMSC@561,COG1088@1,COG1088@2	NA|NA|NA	F	Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction
b2042	155864.EDL933_3113	2.4e-164	584.7	Escherichia	galF	GO:0003674,GO:0003824,GO:0003983,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016772,GO:0016779,GO:0044424,GO:0044444,GO:0044464,GO:0051748,GO:0070569	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000				Escherichia	1MV5F@1224,1RMHB@1236,3XNJT@561,COG1210@1,COG1210@2	NA|NA|NA	M	UTP:glucose-1-phosphate uridylyltransferase activity
b2043	316407.1736746	7.8e-271	939.1	Escherichia	wcaM			ko:K16711					ko00000				Escherichia	1R6F2@1224,1RZKI@1236,2C3PH@1,2Z7QB@2,3XMQI@561	NA|NA|NA	M	slime layer organization
b2044	316407.1736747	5.9e-230	803.1	Escherichia	wcaL	GO:0003674,GO:0003824,GO:0016740,GO:0016757		ko:K16703					ko00000,ko01000,ko01003		GT4		Escherichia	1MVKK@1224,1RQ8J@1236,3XNDB@561,COG0438@1,COG0438@2	NA|NA|NA	M	colanic acid biosynthesis glycosyl transferase
b2045	316407.85675198	3.7e-243	847.0	Escherichia	wcaK			ko:K16710					ko00000			iECSF_1327.ECSF_1934,iSBO_1134.SBO_0872	Escherichia	1MXWP@1224,1RRDB@1236,3XMBT@561,COG2327@1,COG2327@2	NA|NA|NA	S	slime layer organization
b2046	316407.1736748	5.8e-256	889.8	Escherichia	wzxC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K16695					ko00000,ko02000	2.A.66.2.7			Escherichia	1R9I0@1224,1RP3V@1236,3XPF6@561,COG2244@1,COG2244@2	NA|NA|NA	S	lipopolysaccharide biosynthetic process
b2047	316407.1736749	8.7e-270	935.6	Escherichia	wcaJ	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046377,GO:0071704,GO:0071944,GO:0089702,GO:1901135,GO:1901137,GO:1901576		ko:K03606	ko05111,map05111				ko00000,ko00001				Escherichia	1MV6W@1224,1RMMN@1236,3XMRD@561,COG2148@1,COG2148@2	NA|NA|NA	M	Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl- pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity
b2048	316407.85675199	9.4e-269	932.2	Escherichia	cpsG		5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000			iECS88_1305.ECS88_2145,iECUMN_1333.ECUMN_2384,iUTI89_1310.UTI89_C2321	Escherichia	1MUA5@1224,1RMU8@1236,3XN19@561,COG1109@1,COG1109@2	NA|NA|NA	F	Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS
b2049	316407.1736755	3.4e-269	933.7	Escherichia	cpsB	GO:0000271,GO:0003674,GO:0003824,GO:0004475,GO:0005975,GO:0005976,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008905,GO:0009058,GO:0009059,GO:0009242,GO:0009628,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046377,GO:0050896,GO:0070568,GO:0071704,GO:1901135,GO:1901137,GO:1901576	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2191,iEC042_1314.EC042_2286,iECIAI1_1343.ECIAI1_2124,iECO26_1355.ECO26_2960,iECSE_1348.ECSE_2323,iECW_1372.ECW_m2206,iEKO11_1354.EKO11_1746,iEcE24377_1341.EcE24377A_2342,iLF82_1304.LF82_0345,iNRG857_1313.NRG857_10420,iWFL_1372.ECW_m2206	Escherichia	1MV39@1224,1RNQI@1236,3XMD8@561,COG0662@1,COG0662@2,COG0836@1,COG0836@2	NA|NA|NA	GM	mannose-1-phosphate guanylyltransferase
b2050	316407.1736756	4.6e-235	820.1	Escherichia	wcaI	GO:0003674,GO:0003824,GO:0016740,GO:0016757		ko:K03208					ko00000		GT4		Escherichia	1QV3H@1224,1T26X@1236,3XNR0@561,COG0297@1,COG0297@2	NA|NA|NA	G	slime layer organization
b2051	316407.85675200	1.5e-88	332.0	Escherichia	gmm	GO:0000287,GO:0003674,GO:0003824,GO:0004553,GO:0005488,GO:0015926,GO:0016787,GO:0016798,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047917		ko:K03207					ko00000,ko01000			iECBD_1354.ECBD_1604	Escherichia	1MZDA@1224,1S6M4@1236,3XPJG@561,COG1051@1,COG1051@2	NA|NA|NA	F	Belongs to the Nudix hydrolase family
b2052	316407.1736758	4.1e-186	657.1	Escherichia	fcl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042350,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046368,GO:0046483,GO:0050577,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100		R05692	RC01014	ko00000,ko00001,ko01000			iECP_1309.ECP_2092,iLF82_1304.LF82_0626,iNRG857_1313.NRG857_10435	Escherichia	1MUGT@1224,1RMPQ@1236,3XMRE@561,COG0451@1,COG0451@2	NA|NA|NA	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction
b2053	155864.EDL933_3126	4.4e-216	756.9	Escherichia	gmd	GO:0003674,GO:0003824,GO:0008446,GO:0016829,GO:0016835,GO:0016836	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100		R00888	RC00402	ko00000,ko00001,ko01000				Escherichia	1MUX0@1224,1RMIY@1236,3XMI8@561,COG1089@1,COG1089@2	NA|NA|NA	F	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
b2054	198214.SF2117	6.1e-102	376.7	Gammaproteobacteria													Escherichia	1R6A3@1224,1RQXV@1236,COG0110@1,COG0110@2	NA|NA|NA	S	colanic acid biosynthesis acetyltransferase wcaF
b2055	316407.85675201	3.1e-141	507.7	Escherichia	wcaE	GO:0003674,GO:0003824,GO:0016740,GO:0016757		ko:K13683					ko00000,ko01000,ko01003		GT2		Escherichia	1RB30@1224,1RPV7@1236,3XMBU@561,COG1216@1,COG1216@2	NA|NA|NA	S	colanic acid biosynthesis glycosyl transferase
b2056	316407.85675202	3e-218	764.2	Escherichia	wcaD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K13620					ko00000				Escherichia	1R6FP@1224,1RQGA@1236,28KKV@1,2ZA5M@2,3XNAH@561	NA|NA|NA	S	slime layer organization
b2057	316407.85675203	1e-237	828.9	Escherichia	wcaC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035250,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K13684					ko00000,ko01000,ko01003		GT4		Escherichia	1MWYH@1224,1S01S@1236,3XNNM@561,COG0438@1,COG0438@2	NA|NA|NA	M	lipopolysaccharide-1,6-galactosyltransferase activity
b2058	155864.EDL933_3131	1.1e-81	309.3	Escherichia	wcaB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607		ko:K03819					ko00000,ko01000			iECW_1372.ECW_m2215,iWFL_1372.ECW_m2215	Escherichia	1MZSE@1224,1RRT1@1236,3XNK4@561,COG1045@1,COG1045@2	NA|NA|NA	E	serine O-acetyltransferase activity
b2059	316407.1736762	1.9e-163	581.6	Escherichia	wcaA	GO:0003674,GO:0003824,GO:0016740,GO:0016757											Escherichia	1QV3I@1224,1RY93@1236,3XN3F@561,COG0463@1,COG0463@2	NA|NA|NA	M	slime layer organization
b2060	316407.1736763	0.0	1375.1	Escherichia	wzc	GO:0000271,GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016020,GO:0016021,GO:0016051,GO:0016301,GO:0016310,GO:0016462,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0031224,GO:0031226,GO:0033692,GO:0034637,GO:0034645,GO:0036211,GO:0038083,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046377,GO:0046777,GO:0071704,GO:0071944,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576		ko:K16692					ko00000,ko01000,ko01001				Escherichia	1MVI9@1224,1RNB0@1236,3XN7H@561,COG0489@1,COG0489@2,COG3206@1,COG3206@2	NA|NA|NA	DM	Tyrosine-protein kinase
b2061	155864.EDL933_3134	6.9e-80	303.1	Escherichia	wzb	GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576	3.1.3.48	ko:K01104					ko00000,ko01000				Escherichia	1N0DZ@1224,1S92S@1236,3XPM0@561,COG0394@1,COG0394@2	NA|NA|NA	T	low molecular weight
b2062	316407.85675205	1.2e-216	758.8	Escherichia	wza			ko:K01991	ko02026,map02026				ko00000,ko00001,ko02000	1.B.18			Escherichia	1N7GP@1224,1RQSM@1236,3XNQG@561,COG1596@1,COG1596@2	NA|NA|NA	M	polysaccharide export protein
b2063	316407.85675206	1.8e-287	994.6	Escherichia	yegH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1QTUN@1224,1RMTY@1236,3XN66@561,COG1253@1,COG1253@2	NA|NA|NA	P	flavin adenine dinucleotide binding
b2064	316407.1736768	0.0	1212.2	Escherichia	asmA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475		ko:K07289					ko00000				Escherichia	1NVUY@1224,1RPFM@1236,3XMB9@561,COG2982@1,COG2982@2	NA|NA|NA	M	Involved in the inhibition of assembly of mutant ompF proteins. In general, could be involved in the assembly of outer membrane proteins
b2065	316407.1736769	1.8e-107	395.2	Escherichia	dcd	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009314,GO:0009628,GO:0009987,GO:0015949,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:1901360	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000				Escherichia	1MV2J@1224,1RMCD@1236,3XNIE@561,COG0717@1,COG0717@2	NA|NA|NA	F	Deoxycytidine triphosphate deaminase
b2066	155864.EDL933_3141	1.5e-115	422.2	Escherichia	udk	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100		R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000			iSBO_1134.SBO_0893	Escherichia	1MWCH@1224,1RNZG@1236,3XNQP@561,COG0572@1,COG0572@2	NA|NA|NA	F	CTP salvage
b2067	316407.1736771	0.0	2153.6	Escherichia	yegE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.7.65	ko:K21084	ko02026,map02026				ko00000,ko00001,ko01000				Escherichia	1MU2C@1224,1T2TF@1236,3XNYH@561,COG3447@1,COG3447@2,COG5001@1,COG5001@2,COG5002@1,COG5002@2	NA|NA|NA	T	diguanylate cyclase activity
b2068	316407.1736778	1.1e-163	582.4	Escherichia	alkA	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003905,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008725,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0032131,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0043733,GO:0043916,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.21	ko:K01247	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Escherichia	1N4N4@1224,1T1FZ@1236,3XMCS@561,COG0122@1,COG0122@2	NA|NA|NA	L	Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2- methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions
b2069	316407.1736779	4.8e-257	893.3	Escherichia	yegD			ko:K04046					ko00000,ko03110	1.A.33			Escherichia	1MXBT@1224,1RN4U@1236,3XNI2@561,COG0443@1,COG0443@2	NA|NA|NA	O	ATP binding
b2070	316407.85675207	0.0	1294.6	Escherichia	yegI												Escherichia	1MWZX@1224,1S1BZ@1236,3XQX7@561,COG4248@1,COG4248@2	NA|NA|NA	S	protein kinase activity
b2071	316407.85675208	5.3e-83	313.5	Gammaproteobacteria													Escherichia	1R3Q7@1224,1SGE0@1236,COG3779@1,COG3779@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2314)
b2072	316407.85675209	1e-139	502.7	Escherichia	yegK												Escherichia	1RIEE@1224,1SBI8@1236,3XQI7@561,COG0631@1,COG0631@2	NA|NA|NA	T	Protein phosphatase 2C
b2073	316407.85675210	5.8e-123	446.8	Escherichia	yegL												Escherichia	1MVUE@1224,1RZUX@1236,3XQ97@561,COG4245@1,COG4245@2	NA|NA|NA	S	von Willebrand factor type A domain
b2074	316407.85675211	9.6e-212	742.7	Escherichia	mdtA	GO:0008150,GO:0008219,GO:0009987,GO:0012501		ko:K07799	ko02020,map02020	M00648			ko00000,ko00001,ko00002,ko02000	8.A.1			Escherichia	1MW65@1224,1RQ67@1236,3XM7P@561,COG0845@1,COG0845@2	NA|NA|NA	M	The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate
b2075	316407.1736781	0.0	1908.3	Escherichia	mdtB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K07788	ko02020,map02020	M00648			ko00000,ko00001,ko00002,ko02000	2.A.6.2			Escherichia	1MU48@1224,1RMBN@1236,3XNGJ@561,COG0841@1,COG0841@2	NA|NA|NA	V	The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate
b2076	316407.1736785	0.0	1917.9	Escherichia	mdtC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015307,GO:0015318,GO:0015672,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K07789	ko02020,map02020	M00648			ko00000,ko00001,ko00002,ko02000	2.A.6.2			Escherichia	1MU48@1224,1RMBN@1236,3XNUD@561,COG0841@1,COG0841@2	NA|NA|NA	V	The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate
b2077	316407.1736786	3e-254	884.0	Escherichia	mdtD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K18326	ko02020,map02020				ko00000,ko00001,ko02000	2.A.1.3.26			Escherichia	1MUDA@1224,1RP1M@1236,3XM8J@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b2078	316407.1736787	4.2e-264	916.8	Escherichia	baeS	GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0019538,GO:0023014,GO:0023052,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1N17V@1224,1RNI8@1236,3XMXB@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
b2079	199310.c2605	3.6e-134	484.2	Escherichia	baeR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001023,GO:2001141		ko:K07664	ko02020,map02020	M00450,M00645,M00646,M00648			ko00000,ko00001,ko00002,ko02022				Escherichia	1MVCB@1224,1RMD0@1236,3XMHX@561,COG0745@1,COG0745@2	NA|NA|NA	K	Member of the two-component regulatory system BaeS BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon
b2080	316407.85675212	5.9e-52	209.9	Escherichia	yegP	GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360		ko:K09946					ko00000				Escherichia	1N0S6@1224,1S8R7@1236,3XPP9@561,COG3422@1,COG3422@2	NA|NA|NA	S	double-strand break repair
b2081	316407.1736789	1.9e-269	934.5	Escherichia	yegQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K08303	ko05120,map05120				ko00000,ko00001,ko01000,ko01002				Escherichia	1MUQG@1224,1RNPY@1236,3XNIC@561,COG0826@1,COG0826@2	NA|NA|NA	O	peptidase activity
b2082	316407.1736790	3.5e-37	160.2	Escherichia	ogrK												Escherichia	1N7EE@1224,1SD3G@1236,2E32U@1,32Y32@2,3XQ5I@561	NA|NA|NA	K	Cryptic version of the phage P2 OGR protein which acts as an activator of P2 late transcription
b2083	1440052.EAKF1_ch0554c	5.5e-30	136.3	Escherichia				ko:K06905					ko00000				Escherichia	1MXT8@1224,1RMKC@1236,3XQXC@561,COG3500@1,COG3500@2	NA|NA|NA	S	Phage late control gene D protein (GPD)
b2085	316407.85675213	4.3e-52	210.3	Gammaproteobacteria													Escherichia	1N9FT@1224,1SEIA@1236,2E6XX@1,331H8@2	NA|NA|NA		
b2086	316407.1736792	1e-170	605.9	Escherichia	yegS	GO:0001727,GO:0003674,GO:0003824,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0030258,GO:0044237,GO:0044238,GO:0044255,GO:0046834,GO:0071704											Escherichia	1MY37@1224,1RMX9@1236,3XMZW@561,COG1597@1,COG1597@2	NA|NA|NA	F	the in vivo substrate is
b2088	1440052.EAKF1_ch3017c	7.7e-43	179.5	Escherichia		GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K07483					ko00000				Escherichia	1RHBZ@1224,1S69Y@1236,3XR2P@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
b2089	316407.1736794	5.7e-171	606.7	Gammaproteobacteria													Escherichia	1MVXQ@1224,1RR4F@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
b2091	155864.EDL933_3160	1.2e-196	692.2	Escherichia	gatD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006059,GO:0006066,GO:0008150,GO:0008152,GO:0008270,GO:0008868,GO:0009056,GO:0009987,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019400,GO:0019402,GO:0019404,GO:0019405,GO:0019407,GO:0019751,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901575,GO:1901615,GO:1901616	1.1.1.251	ko:K00094	ko00052,ko01100,map00052,map01100		R05571	RC00085	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_2182,iECSF_1327.ECSF_1973	Escherichia	1MXTX@1224,1RN1R@1236,3XQPB@561,COG1063@1,COG1063@2	NA|NA|NA	E	5-dehydrogenase
b2092	155864.EDL933_3161	7e-168	597.0	Gammaproteobacteria													Escherichia	1MVRC@1224,1RQ76@1236,COG3775@1,COG3775@2	NA|NA|NA	G	system Galactitol-specific IIC component
b2093	316407.1736810	1.4e-46	191.8	Gammaproteobacteria													Escherichia	1RHBP@1224,1S5Y7@1236,COG3414@1,COG3414@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of GatA, GatB and GatC is involved in galactitol transport
b2094	155864.EDL933_3163	6e-79	300.1	Gammaproteobacteria													Escherichia	1RDXB@1224,1S5QX@1236,COG1762@1,COG1762@2	NA|NA|NA	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system
b2095	316407.1736821	2.1e-243	847.8	Escherichia	gatZ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K16371	ko00052,ko01100,map00052,map01100		R01069	RC00438,RC00439	ko00000,ko00001			iE2348C_1286.E2348C_2240,iECO111_1330.ECO111_2811,iECO26_1355.ECO26_3004	Escherichia	1MW3Q@1224,1RQAU@1236,3XNDM@561,COG4573@1,COG4573@2	NA|NA|NA	G	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
b2096	316407.85675217	2.5e-158	564.7	Escherichia	gatY	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009025,GO:0009987,GO:0016043,GO:0016829,GO:0016830,GO:0016832,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071840	4.1.2.40	ko:K08302	ko00052,ko01100,map00052,map01100		R01069	RC00438,RC00439	ko00000,ko00001,ko01000			iAF1260.b3137,iAPECO1_1312.APECO1_3290,iB21_1397.B21_02955,iBWG_1329.BWG_2841,iEC042_1314.EC042_3431,iEC55989_1330.EC55989_3557,iECABU_c1320.ECABU_c35530,iECBD_1354.ECBD_0603,iECB_1328.ECB_03004,iECDH10B_1368.ECDH10B_3310,iECDH1ME8569_1439.ECDH1ME8569_3028,iECD_1391.ECD_03004,iECED1_1282.ECED1_3801,iECH74115_1262.ECH74115_4454,iECIAI1_1343.ECIAI1_3287,iECO103_1326.ECO103_3884,iECO111_1330.ECO111_3961,iECO26_1355.ECO26_4242,iECOK1_1307.ECOK1_3561,iECP_1309.ECP_3229,iECS88_1305.ECS88_3525,iECSE_1348.ECSE_3423,iECSP_1301.ECSP_4111,iECW_1372.ECW_m3407,iECs_1301.ECs4017,iEKO11_1354.EKO11_0580,iETEC_1333.ETEC_3404,iEcDH1_1363.EcDH1_0568,iEcE24377_1341.EcE24377A_3619,iEcHS_1320.EcHS_A3329,iEcolC_1368.EcolC_0561,iG2583_1286.G2583_2628,iG2583_1286.G2583_3861,iJO1366.b3137,iJR904.b3137,iLF82_1304.LF82_1138,iNRG857_1313.NRG857_15590,iUMN146_1321.UM146_00665,iUMNK88_1353.UMNK88_3896,iUTI89_1310.UTI89_C3568,iWFL_1372.ECW_m3407,iY75_1357.Y75_RS16275,iZ_1308.Z4491,ic_1306.c3894	Escherichia	1MURX@1224,1RQUC@1236,3XPA4@561,COG0191@1,COG0191@2	NA|NA|NA	F	which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6- bisphosphate (TBP). Requires
b2097	155864.EDL933_3166	3.5e-199	700.7	Escherichia	fbaB	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016829,GO:0016830,GO:0016832,GO:0042802,GO:0044424,GO:0044444,GO:0044464	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000			iSBO_1134.SBO_0918	Escherichia	1MW9N@1224,1RQHJ@1236,3XP5V@561,COG1830@1,COG1830@2	NA|NA|NA	F	fructose-bisphosphate aldolase activity
b2098	316407.1736823	1.5e-239	835.1	Escherichia	yegT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944										iECW_1372.ECW_m2299,iWFL_1372.ECW_m2299	Escherichia	1MWI9@1224,1RMU5@1236,3XNA7@561,COG2211@1,COG2211@2	NA|NA|NA	P	nucleoside transporter
b2099	316407.85675219	4.3e-186	657.1	Escherichia	yegU												Escherichia	1NTUR@1224,1RMPE@1236,3XP4M@561,COG1397@1,COG1397@2	NA|NA|NA	O	hydrolase activity
b2100	316407.85675220	7.7e-185	652.9	Escherichia	yegV	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704											Escherichia	1PDS9@1224,1RQE5@1236,3XNQU@561,COG0524@1,COG0524@2	NA|NA|NA	G	belongs to the carbohydrate kinase PfkB family
b2101	155864.EDL933_3170	6.7e-136	490.0	Escherichia	yegW												Escherichia	1P6ZJ@1224,1RPDA@1236,3XN07@561,COG2188@1,COG2188@2	NA|NA|NA	K	Transcriptional regulator
b2102	316407.85675221	7.6e-157	559.7	Escherichia	yegX			ko:K07273					ko00000				Escherichia	1N792@1224,1SC72@1236,3XMFS@561,COG3757@1,COG3757@2	NA|NA|NA	M	lysozyme activity
b2103	316407.1736827	1.5e-146	525.4	Escherichia	thiD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008902,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iG2583_1286.G2583_2635	Escherichia	1MU9J@1224,1RNFP@1236,3XP7H@561,COG0351@1,COG0351@2	NA|NA|NA	H	Phosphomethylpyrimidine kinase
b2104	316407.1736828	1.3e-142	512.3	Escherichia	thiM	GO:0003674,GO:0003824,GO:0004417,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0036172,GO:0042364,GO:0042723,GO:0042724,GO:0042802,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.50	ko:K00878	ko00730,ko01100,map00730,map01100	M00127	R04448	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c24340,iLF82_1304.LF82_2255,iNRG857_1313.NRG857_10680,iSFV_1184.SFV_2159,iSF_1195.SF2166,iSFxv_1172.SFxv_2394,iS_1188.S2291,ic_1306.c2631	Escherichia	1MVES@1224,1RRAE@1236,3XNG3@561,COG2145@1,COG2145@2	NA|NA|NA	F	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
b2105	155864.EDL933_3177	3e-41	174.1	Escherichia	rcnR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141											Escherichia	1N6ZN@1224,1S75M@1236,3XR30@561,COG1937@1,COG1937@2	NA|NA|NA	K	Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter
b2106	316407.1736829	4.2e-115	421.0	Escherichia	rcnA	GO:0000041,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010045,GO:0015075,GO:0015099,GO:0015318,GO:0015562,GO:0015675,GO:0016020,GO:0016021,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0032025,GO:0034220,GO:0035444,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K08970					ko00000,ko02000	2.A.52.2			Escherichia	1QDA1@1224,1RPK1@1236,3XQ5V@561,COG2215@1,COG2215@2	NA|NA|NA	U	Efflux system for nickel and cobalt
b2107	199310.c2634	3.9e-59	233.8	Escherichia	rcnB	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010045,GO:0010243,GO:0030288,GO:0030313,GO:0031975,GO:0032025,GO:0033554,GO:0042221,GO:0042597,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:1901652,GO:1901698,GO:1901700											Escherichia	1RI8X@1224,1S6JE@1236,3XPS0@561,COG5455@1,COG5455@2	NA|NA|NA	S	Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux
b2108	316407.1736830	2.4e-184	651.4	Escherichia	yehA	GO:0007155,GO:0008150,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0043709,GO:0044010,GO:0044764,GO:0051704,GO:0090605,GO:0090609											Escherichia	1RAR0@1224,1S25S@1236,3XQ9J@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
b2109	316407.85675224	0.0	1680.2	Escherichia	yehB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071840,GO:0071944		ko:K07347	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Escherichia	1MUHE@1224,1RMPU@1236,3XN71@561,COG3188@1,COG3188@2	NA|NA|NA	NU	outer membrane usher protein
b2110	316407.85675225	3.3e-132	477.6	Escherichia	yehC												Escherichia	1R6JB@1224,1RRS0@1236,3XNUS@561,COG3121@1,COG3121@2	NA|NA|NA	NU	fimbrial chaperone
b2111	316407.85675226	5.1e-93	347.1	Escherichia	yehD	GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0022610,GO:0042995,GO:0044464											Escherichia	1N9MK@1224,1SFKQ@1236,3XQ6D@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches
b2112	316407.85675227	2.4e-46	191.0	Escherichia	yehE												Escherichia	1NDQB@1224,1SEHZ@1236,2E71U@1,331KG@2,3XR50@561	NA|NA|NA	S	Protein of unknown function (DUF2574)
b2113	155864.EDL933_3185	6.1e-210	736.5	Escherichia	mrp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K03593					ko00000,ko03029,ko03036				Escherichia	1MU7R@1224,1RMJF@1236,3XM4T@561,COG0489@1,COG0489@2	NA|NA|NA	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
b2114	316407.85675229	0.0	1383.2	Escherichia	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446	Escherichia	1MUBY@1224,1RMYM@1236,3XN5R@561,COG0073@1,COG0073@2,COG0143@1,COG0143@2	NA|NA|NA	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
b2115	469008.B21_02003	1.9e-147	528.5	Escherichia	JD73_20480												Escherichia	1QWC3@1224,1S9SY@1236,3XNVN@561,COG3831@1,COG3831@2	NA|NA|NA	S	Proposed nucleic acid binding domain
b2118	316407.85675230	0.0	2452.9	Escherichia	yehI												Escherichia	1QWC3@1224,1S9SY@1236,3XNKN@561,COG3831@1,COG3831@2	NA|NA|NA	S	Domain of unknown function (DUF4132)
b4541	316407.85675231	7.9e-54	216.1	Gammaproteobacteria													Escherichia	1NWZ7@1224,1SP51@1236,2F5M5@1,33Y6A@2	NA|NA|NA		
b2119	316407.85675232	2.4e-203	714.5	Escherichia	yehL												Escherichia	1QDUZ@1224,1RQGT@1236,3XN4P@561,COG0714@1,COG0714@2	NA|NA|NA	S	ATPase activity
b2120	316407.85675233	0.0	1533.1	Escherichia	yehM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1QV44@1224,1T27M@1236,3XP4U@561,COG2425@1,COG2425@2	NA|NA|NA	S	protein containing a von Willebrand factor type A (vWA) domain
b2121	316407.85675234	8.8e-212	742.7	Escherichia	yehP												Escherichia	1QW9Y@1224,1T2TG@1236,3XNYJ@561,COG3552@1,COG3552@2	NA|NA|NA	S	VWA domain containing CoxE-like protein
b2122	316407.85675235	0.0	1227.2	Escherichia	yehQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1R7Q0@1224,1S927@1236,3XNHR@561,COG4715@1,COG4715@2	NA|NA|NA	S	SWIM zinc finger
b2123	155864.EDL933_3200	1.4e-75	288.9	Escherichia	yehR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464										iECW_1372.ECW_m2324,iWFL_1372.ECW_m2324	Escherichia	1RG9F@1224,1S537@1236,3XPYC@561,COG4808@1,COG4808@2	NA|NA|NA	S	Protein of unknown function (DUF1307)
b2124	316407.85675237	7.8e-82	309.7	Escherichia	yehS												Escherichia	1RD33@1224,1S3ZU@1236,3XPFU@561,COG4807@1,COG4807@2	NA|NA|NA	S	Protein of unknown function (DUF1456)
b2125	155864.EDL933_3202	9e-130	469.5	Escherichia	yehT	GO:0000160,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K02477					ko00000,ko02022				Escherichia	1MUE8@1224,1RMJJ@1236,3XMQB@561,COG3279@1,COG3279@2	NA|NA|NA	K	Member of the two-component regulatory system BtsS BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS BtsR, the low-affinity pyruvate signaling system YpdA YpdB and their respective target proteins, YjiY and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR regulates expression of yjiY by binding to its promoter region. Activation of the BtsS BtsR signaling cascade also suppresses YpdA YpdB-mediated yhjX induction
b2126	198214.SF2198	1e-304	1052.0	Gammaproteobacteria													Escherichia	1QUB1@1224,1T1RX@1236,COG3275@1,COG3275@2	NA|NA|NA	T	Histidine kinase
b2127	316407.85675240	2e-140	505.0	Escherichia	mlrA	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141		ko:K21089	ko02026,map02026				ko00000,ko00001,ko03000				Escherichia	1R9SN@1224,1S967@1236,3XNCJ@561,COG0789@1,COG0789@2	NA|NA|NA	K	transcriptional regulator
b4542	316407.85675241	9.8e-09	64.7	Escherichia	yohO												Escherichia	1QNAB@1224,1TKTR@1236,2BT6J@1,32NBR@2,3XRE6@561	NA|NA|NA		
b2128	316407.85675242	1.7e-120	438.7	Escherichia	yehW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0072337		ko:K05846	ko02010,map02010	M00209			ko00000,ko00001,ko00002,ko02000	3.A.1.12		iECUMN_1333.ECUMN_2462	Escherichia	1MX8D@1224,1RSDR@1236,3XMU1@561,COG1174@1,COG1174@2	NA|NA|NA	P	Permease protein
b2129	316407.85675243	2.1e-171	608.2	Escherichia	yehX	GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0031460,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337		ko:K05847	ko02010,map02010	M00209			ko00000,ko00001,ko00002,ko02000	3.A.1.12		iECED1_1282.ECED1_2573,iEcE24377_1341.EcE24377A_2418	Escherichia	1QTUC@1224,1RQWQ@1236,3XNHI@561,COG1125@1,COG1125@2	NA|NA|NA	P	ATP-binding protein
b2130	316407.85675244	5.2e-204	716.8	Escherichia	yehY	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0072337		ko:K05846	ko02010,map02010	M00209			ko00000,ko00001,ko00002,ko02000	3.A.1.12		iECNA114_1301.ECNA114_2219,iECSF_1327.ECSF_2012,iETEC_1333.ETEC_2266	Escherichia	1MXA1@1224,1RQDV@1236,3XN5U@561,COG1174@1,COG1174@2	NA|NA|NA	P	Permease protein
b2131	316407.85675245	1.5e-166	592.0	Escherichia	osmF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0033554,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0104004		ko:K05845	ko02010,map02010	M00209			ko00000,ko00001,ko00002,ko02000	3.A.1.12		iE2348C_1286.E2348C_2278,iEC55989_1330.EC55989_2381,iECIAI39_1322.ECIAI39_0865,iECO103_1326.ECO103_2607,iECSE_1348.ECSE_2399	Escherichia	1MV9N@1224,1RN72@1236,3XM88@561,COG1732@1,COG1732@2	NA|NA|NA	M	Part of an ABC transporter complex involved in low- affinity glycine betaine uptake. Binds glycine betaine with low affinity
b2132	316407.85675246	0.0	1513.4	Escherichia	bglX	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008422,GO:0009056,GO:0009057,GO:0009251,GO:0015926,GO:0016020,GO:0016052,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044042,GO:0044238,GO:0044464,GO:0071704,GO:0071944,GO:1901575	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110		R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000		GH3	iECOK1_1307.ECOK1_2363,iECS88_1305.ECS88_2276,iSF_1195.SF2217,iSFxv_1172.SFxv_2448,iS_1188.S2346,iUMN146_1321.UM146_06125,iUTI89_1310.UTI89_C2406	Escherichia	1MVIV@1224,1RMA0@1236,3XN99@561,COG1472@1,COG1472@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 3 family
b2133	316407.85675247	0.0	1168.7	Escherichia	dld	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016898,GO:0016901,GO:0019516,GO:0019752,GO:0019897,GO:0019898,GO:0022900,GO:0022904,GO:0031234,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901615	1.1.5.12	ko:K03777	ko00620,ko01120,map00620,map01120		R00704,R11591	RC00044	ko00000,ko00001,ko01000			iEcHS_1320.EcHS_A2268	Escherichia	1MVG7@1224,1RN5V@1236,3XNSW@561,COG0277@1,COG0277@2	NA|NA|NA	C	Catalyzes the oxidation of D-lactate to pyruvate
b2134	198214.SF2219	1.6e-166	592.0	Gammaproteobacteria													Escherichia	1MWZA@1224,1RQBF@1236,COG1686@1,COG1686@2	NA|NA|NA	M	Belongs to the peptidase S11 family
b2135	155864.EDL933_3290	1.3e-89	335.9	Escherichia	yohC	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944											Escherichia	1MW9T@1224,1RQV1@1236,28H8Z@1,2Z7KS@2,3XP9F@561	NA|NA|NA	S	cellular response to DNA damage stimulus
b2136	316407.85675250	4.3e-106	390.6	Escherichia	yohD	GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0032505,GO:0043093,GO:0044464,GO:0051301,GO:0071944											Escherichia	1R5SJ@1224,1S274@1236,3XMGA@561,COG0586@1,COG0586@2	NA|NA|NA	S	reproductive process
b2137	316407.85675251	7.1e-141	506.5	Escherichia	yohF												Escherichia	1Q7EW@1224,1RPFV@1236,3XMUI@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	oxidoreductase activity
b2140	316407.85675254	1.3e-181	642.1	Escherichia	dusC	GO:0000049,GO:0000166,GO:0002943,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010181,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0032553,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363		ko:K05541					ko00000,ko01000,ko03016				Escherichia	1MUSM@1224,1RMMM@1236,3XNQI@561,COG0042@1,COG0042@2	NA|NA|NA	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
b2141	198214.SF2226	5.9e-46	190.3	Gammaproteobacteria													Escherichia	1NAY3@1224,1SD5V@1236,COG1380@1,COG1380@2	NA|NA|NA	S	UPF0299 membrane protein
b2142	198214.SF2227	1.4e-116	425.6	Gammaproteobacteria													Escherichia	1MV81@1224,1RS5C@1236,COG1346@1,COG1346@2	NA|NA|NA	M	effector of murein hydrolase
b2143	198214.SF2228	1.9e-166	591.7	Gammaproteobacteria													Escherichia	1MY2R@1224,1RMRX@1236,COG0295@1,COG0295@2	NA|NA|NA	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
b2144	155864.EDL933_3305	1.8e-122	445.3	Escherichia	sanA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0071944		ko:K03748					ko00000				Escherichia	1MURW@1224,1RMG7@1236,3XPEI@561,COG2949@1,COG2949@2	NA|NA|NA	S	Participates in the barrier function of the cell envelope
b2145	155864.EDL933_3306	3.5e-38	163.7	Escherichia	yeiS												Escherichia	1NA12@1224,1SFRD@1236,2EAMC@1,334PZ@2,3XQ2A@561	NA|NA|NA	S	Protein of unknown function (DUF2542)
b2146	316407.85675260	8.6e-237	825.9	Escherichia	preT	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0048037,GO:0051536,GO:0051540,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.3.1.1	ko:K17722	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_2593,iECO103_1326.ECO103_2621,iLF82_1304.LF82_3021	Escherichia	1MU2H@1224,1RS6R@1236,3XMQ4@561,COG0493@1,COG0493@2	NA|NA|NA	C	Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6- dihydrothymine (DHT)
b2147	155864.EDL933_3308	7.8e-230	802.7	Escherichia	preA	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0048037,GO:0051536,GO:0051540,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2293	Escherichia	1MXER@1224,1RRTA@1236,3XNY7@561,COG0167@1,COG0167@2,COG1146@1,COG1146@2	NA|NA|NA	CF	Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6- dihydrothymine (DHT)
b2148	316407.85675262	2e-167	595.1	Escherichia	mglC	GO:0003674,GO:0005215,GO:0005354,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0008645,GO:0009987,GO:0015144,GO:0015145,GO:0015149,GO:0015592,GO:0015749,GO:0015757,GO:0015765,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0033554,GO:0034219,GO:0044425,GO:0044464,GO:0050896,GO:0051119,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:1901264,GO:1901505,GO:1901656		ko:K10541	ko02010,map02010	M00214			ko00000,ko00001,ko00002,ko02000	3.A.1.2.3		iECABU_c1320.ECABU_c24780,iECNA114_1301.ECNA114_2239,iECP_1309.ECP_2187,iECSF_1327.ECSF_2030,iLF82_1304.LF82_1340,iNRG857_1313.NRG857_10910,ic_1306.c2682	Escherichia	1N621@1224,1RP8Q@1236,3XNHK@561,COG4211@1,COG4211@2	NA|NA|NA	G	the binding-protein-dependent transport system
b2149	198214.SF2234	1.5e-288	998.0	Gammaproteobacteria													Escherichia	1MU22@1224,1RMCH@1236,COG1129@1,COG1129@2	NA|NA|NA	P	import. Responsible for energy coupling to the transport system
b2150	198214.SF2235	2.6e-183	647.9	Gammaproteobacteria													Escherichia	1MWGU@1224,1RPE9@1236,COG1879@1,COG1879@2	NA|NA|NA	G	Wtih MglAC is involved in the transport of beta-methylgalactoside
b2151	316407.85675265	1.3e-190	672.2	Escherichia	galS	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K02529					ko00000,ko03000				Escherichia	1MU1G@1224,1RMSP@1236,3XMV1@561,COG1609@1,COG1609@2	NA|NA|NA	K	Repressor of the mgl operon. Binds galactose and D- fucose as inducers. GalS binds to an operator DNA sequence within its own coding sequence (corresponding to residues 15 to 20)
b2152	316407.85675266	1.4e-220	771.9	Escherichia	yeiB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07148					ko00000				Escherichia	1MWHW@1224,1RQ08@1236,3XMAP@561,COG2311@1,COG2311@2	NA|NA|NA	S	Protein of unknown function (DUF418)
b2153	155864.EDL933_3316	1.1e-118	432.6	Escherichia	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006139,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000				Escherichia	1MY3N@1224,1RMQM@1236,3XMJH@561,COG0302@1,COG0302@2	NA|NA|NA	F	GTP cyclohydrolase
b2154	316407.85675268	4.8e-167	593.6	Escherichia	yeiG	GO:0003674,GO:0003824,GO:0004416,GO:0005488,GO:0005515,GO:0006081,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016043,GO:0016787,GO:0016788,GO:0016790,GO:0016999,GO:0017001,GO:0017144,GO:0018738,GO:0022607,GO:0042221,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0046292,GO:0046294,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0065003,GO:0070887,GO:0071704,GO:0071840,GO:0097237,GO:0098754,GO:0110095,GO:0110096,GO:1901575,GO:1901700,GO:1901701,GO:1990748	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200		R00527	RC00167,RC00320	ko00000,ko00001,ko01000		CE1	iE2348C_1286.E2348C_2300	Escherichia	1MUID@1224,1RMR3@1236,3XP8I@561,COG0627@1,COG0627@2	NA|NA|NA	S	Serine hydrolase involved in the detoxification of formaldehyde
b2155	316407.85675269	0.0	1363.6	Escherichia	cirA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006855,GO:0006873,GO:0006875,GO:0006879,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009279,GO:0009987,GO:0015031,GO:0015238,GO:0015343,GO:0015399,GO:0015405,GO:0015450,GO:0015688,GO:0015833,GO:0015891,GO:0015893,GO:0016020,GO:0019725,GO:0019867,GO:0022804,GO:0022857,GO:0022884,GO:0022885,GO:0030003,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033212,GO:0042221,GO:0042493,GO:0042592,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042912,GO:0043213,GO:0044462,GO:0044464,GO:0044718,GO:0045184,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098771,GO:1901678,GO:1904680		ko:K16089					ko00000,ko02000	1.B.14.1,1.B.14.10		iECO103_1326.ECO103_2630	Escherichia	1MUC1@1224,1RNHR@1236,3XM4N@561,COG1629@1,COG4771@2	NA|NA|NA	P	Colicin I receptor
b2156	316407.85675270	9.7e-280	968.8	Escherichia	lysP	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0046982,GO:0046983,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K11733					ko00000,ko02000	2.A.3.1.2		iSBO_1134.SBO_2171	Escherichia	1QTSM@1224,1RNI2@1236,3XP8G@561,COG0833@1,COG0833@2	NA|NA|NA	E	Lysine-specific permease
b2157	199310.c2692	2.9e-162	577.8	Escherichia	yeiE	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1MWVU@1224,1RPT8@1236,3XNEX@561,COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
b2158	155864.EDL933_3322	1.2e-183	649.0	Escherichia	yeiH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MVIP@1224,1RPSG@1236,3XNYN@561,COG2855@1,COG2855@2	NA|NA|NA	S	Conserved hypothetical protein 698
b2159	155864.EDL933_3323	5.7e-163	580.1	Escherichia	nfo	GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Escherichia	1MX4Y@1224,1RQ60@1236,3XNSH@561,COG0648@1,COG0648@2	NA|NA|NA	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
b2160	316407.85675274	3.4e-205	720.7	Escherichia	yeiI		2.7.1.83	ko:K16328	ko00240,map00240		R03315	RC00002,RC00017	ko00000,ko00001,ko01000				Escherichia	1MXSY@1224,1RQKG@1236,3XQ9B@561,COG0524@1,COG0524@2,COG1522@1,COG1522@2	NA|NA|NA	G	phosphotransferase activity, alcohol group as acceptor
b2161	316407.85675275	6.9e-202	709.9	Escherichia	nupX	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505,GO:1901642		ko:K16325					ko00000,ko02000	2.A.41.2.10			Escherichia	1MXXX@1224,1RMBX@1236,3XQ7K@561,COG1972@1,COG1972@2	NA|NA|NA	F	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
b2162	316407.85675276	9.2e-183	646.0	Escherichia	rihB	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045437,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0050263,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	3.2.2.8	ko:K10213	ko00230,ko00240,ko01100,map00230,map00240,map01100		R01245,R01677,R01770,R02137	RC00063,RC00318	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_3298,iECSP_1301.ECSP_3040,iECs_1301.ECs3054,iZ_1308.Z3419	Escherichia	1MUIW@1224,1RQ1V@1236,3XQBU@561,COG1957@1,COG1957@2	NA|NA|NA	F	Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides
b2163	155864.EDL933_3327	2.2e-122	444.9	Escherichia				ko:K16326					ko00000,ko03000				Escherichia	1R53A@1224,1RYMX@1236,3XQKG@561,COG0664@1,COG0664@2	NA|NA|NA	K	Cyclic nucleotide-monophosphate binding domain
b2164	316407.85675278	2.6e-201	708.0	Escherichia	yeiM	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505,GO:1901642		ko:K16324					ko00000,ko02000	2.A.41.2.9			Escherichia	1MXXX@1224,1RMBX@1236,3XQ7K@561,COG1972@1,COG1972@2	NA|NA|NA	F	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
b2165	316407.85675279	5.4e-167	593.6	Escherichia	psuG	GO:0001522,GO:0003674,GO:0003824,GO:0004730,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016043,GO:0016070,GO:0016787,GO:0016798,GO:0016829,GO:0016835,GO:0016836,GO:0022607,GO:0030145,GO:0034641,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0090304,GO:1901360	4.2.1.70	ko:K16329	ko00240,map00240		R01055	RC00432,RC00433	ko00000,ko00001,ko01000				Escherichia	1MUQU@1224,1RQJH@1236,3XQK2@561,COG2313@1,COG2313@2	NA|NA|NA	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway
b2166	316407.85675280	4e-178	630.6	Escherichia	yeiC	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050225	2.7.1.83	ko:K16328	ko00240,map00240		R03315	RC00002,RC00017	ko00000,ko00001,ko01000				Escherichia	1MXSY@1224,1RQKG@1236,3XQEA@561,COG0524@1,COG0524@2	NA|NA|NA	G	pseudouridine kinase activity
b2167	316407.85675281	5.4e-274	949.9	Escherichia	fruA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582	2.7.1.202	ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1		iEcSMS35_1347.EcSMS35_2314,iSbBS512_1146.SbBS512_E0796	Escherichia	1MXFN@1224,1RMZC@1236,3XN1D@561,COG1299@1,COG1299@2,COG1445@1,COG1445@2,COG3925@1,COG3925@2	NA|NA|NA	G	Pts system fructose-specific
b2168	155864.EDL933_3332	3.7e-176	624.0	Escherichia	fruK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0008662,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019318,GO:0019320,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.56	ko:K00882	ko00051,map00051		R02071	RC00002,RC00017	ko00000,ko00001,ko01000			iUMNK88_1353.UMNK88_2713	Escherichia	1MVNW@1224,1RP6K@1236,3XMTQ@561,COG1105@1,COG1105@2	NA|NA|NA	F	Belongs to the carbohydrate kinase PfkB family
b2169	155864.EDL933_3333	9e-201	706.1	Escherichia	fruB	GO:0003674,GO:0003824,GO:0005215,GO:0005353,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0008982,GO:0009401,GO:0015144,GO:0015145,GO:0015149,GO:0015749,GO:0015755,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0019897,GO:0019898,GO:0022804,GO:0022857,GO:0022877,GO:0032445,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	2.7.1.202	ko:K02768,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1		iSBO_1134.SBO_2155,iSbBS512_1146.SbBS512_E0794	Escherichia	1MVP6@1224,1RQP4@1236,3XMPF@561,COG1925@1,COG1925@2,COG4668@1,COG4668@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport
b2170	316407.1736836	1e-215	755.7	Escherichia	setB	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0007059,GO:0008150,GO:0008643,GO:0009987,GO:0015766,GO:0015767,GO:0015772,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071944		ko:K03291					ko00000,ko02000	2.A.1.20		iEC042_1314.EC042_2403	Escherichia	1MWWU@1224,1RN2I@1236,3XMT3@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b4502	316407.85675283	1.3e-43	181.8	Escherichia	yeiW			ko:K06940					ko00000				Escherichia	1MZCU@1224,1SCG7@1236,32S46@2,3XQ19@561,COG0727@1	NA|NA|NA	S	Putative zinc- or iron-chelating domain
b2171	155864.EDL933_3338	4.4e-103	380.6	Escherichia	yeiP	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02356					ko00000,ko03012				Escherichia	1NWY9@1224,1RQ0N@1236,3XNJG@561,COG0231@1,COG0231@2	NA|NA|NA	J	translation elongation factor activity
b2172	316407.85675285	1.5e-288	998.0	Escherichia	yeiQ	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114											Escherichia	1MVZ7@1224,1RNIZ@1236,3XMJP@561,COG0246@1,COG0246@2	NA|NA|NA	G	Belongs to the mannitol dehydrogenase family
b2173	316407.85675286	1.5e-188	665.2	Escherichia	yeiR	GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0008270,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0043167,GO:0043169,GO:0046872,GO:0046914											Escherichia	1MVZV@1224,1RPKP@1236,3XMT1@561,COG0523@1,COG0523@2	NA|NA|NA	S	GTPase activity
b2174	155864.EDL933_3341	1.3e-128	465.7	Escherichia	lpxT	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016817,GO:0016818,GO:0022607,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044464,GO:0045229,GO:0050380,GO:0061024,GO:0071709,GO:0071840,GO:0071944	2.7.4.29	ko:K19803			R11186	RC00002	ko00000,ko01000,ko01005			iAPECO1_1312.APECO1_4380,iSBO_1134.SBO_2150	Escherichia	1MW7A@1224,1RPKF@1236,3XM6N@561,COG0671@1,COG0671@2	NA|NA|NA	I	Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P)
b2175	155864.EDL933_3342	7.7e-100	369.8	Escherichia	spr	GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009254,GO:0016787,GO:0019538,GO:0030203,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901564	3.4.17.13	ko:K13694					ko00000,ko01000,ko01002,ko01011				Escherichia	1N0EE@1224,1RR2X@1236,3XMFK@561,COG0791@1,COG0791@2	NA|NA|NA	M	A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH. Also has weak LD-carboxypeptidase activity on L-mDAP-D-Ala peptide bonds
b2176	316407.1736841	5.6e-302	1042.7	Escherichia	rtn	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008081,GO:0016020,GO:0016787,GO:0016788,GO:0042578,GO:0044464,GO:0071111,GO:0071944											Escherichia	1NJQD@1224,1RNEP@1236,3XM4Z@561,COG2200@1,COG2200@2	NA|NA|NA	T	cyclic-guanylate-specific phosphodiesterase activity
b2177	316407.85675288	0.0	1247.3	Escherichia	yejA	GO:0005575,GO:0005623,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042493,GO:0042597,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705		ko:K13893	ko02010,map02010	M00349			ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24			Escherichia	1MUVU@1224,1RMA1@1236,3XMVP@561,COG4166@1,COG4166@2	NA|NA|NA	E	microcin transport
b2178	155864.EDL933_3345	6.7e-201	706.4	Escherichia	yejB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944		ko:K13894	ko02010,map02010	M00349			ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24			Escherichia	1MVKE@1224,1RMH8@1236,3XNSP@561,COG4174@1,COG4174@2	NA|NA|NA	P	ABC transporter permease
b2179	316407.1736844	5.5e-181	640.2	Escherichia	yejE	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944		ko:K13895	ko02010,map02010	M00349			ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24			Escherichia	1MUM5@1224,1RNUH@1236,3XM4C@561,COG4239@1,COG4239@2	NA|NA|NA	P	ABC transporter permease protein
b2180	316407.85675289	3.7e-293	1013.4	Escherichia	yejF	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K13896	ko02010,map02010	M00349			ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24			Escherichia	1MU09@1224,1RMEI@1236,3XP6C@561,COG1123@1,COG4172@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
b2181	754331.AEME01000001_gene3172	3.9e-62	243.8	Escherichia	yejG												Escherichia	1RHRA@1224,1S625@1236,2ATGA@1,31IZZ@2,3XPSW@561	NA|NA|NA	S	YejG-like protein
b2182	316407.85675291	1.3e-213	748.8	Escherichia	bcr	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0016020,GO:0022857,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:1904680		ko:K07552					ko00000,ko02000	2.A.1.2			Escherichia	1MW19@1224,1RMSZ@1236,3XM69@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b2183	155864.EDL933_3350	1.1e-132	479.2	Escherichia	rsuA	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19	ko:K06183					ko00000,ko01000,ko03009				Escherichia	1MU6M@1224,1RQA9@1236,3XNTC@561,COG1187@1,COG1187@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 516 in 16S ribosomal RNA
b2184	316407.85675293	0.0	1200.7	Escherichia	yejH	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042221,GO:0042493,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051301,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360		ko:K19789					ko00000,ko03400				Escherichia	1MV9F@1224,1RNAN@1236,3XN4B@561,COG1061@1,COG1061@2	NA|NA|NA	L	RNA secondary structure unwinding
b2185	198214.SF2272	1.6e-45	188.3	Gammaproteobacteria													Escherichia	1RDH0@1224,1S46A@1236,COG1825@1,COG1825@2	NA|NA|NA	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
b2186	316407.85675295	1.4e-184	652.1	Escherichia	yejK	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003727,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0009295,GO:0042802,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0097159,GO:1901363		ko:K06899					ko00000,ko03036				Escherichia	1NXJU@1224,1RP8N@1236,3XP37@561,COG3081@1,COG3081@2	NA|NA|NA	S	nucleoid-associated protein
b2187	1440052.EAKF1_ch3798c	2.3e-31	141.0	Escherichia	yejL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09904					ko00000				Escherichia	1MZ9I@1224,1S8XQ@1236,3XQ2C@561,COG3082@1,COG3082@2	NA|NA|NA	S	Belongs to the UPF0352 family
b2188	155864.EDL933_3356	0.0	1171.8	Escherichia	yejM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07014					ko00000				Escherichia	1MX6X@1224,1RPAU@1236,3XP9R@561,COG3083@1,COG3083@2	NA|NA|NA	S	sulfuric ester hydrolase activity
b2192	316407.1736552	5.6e-194	683.3	Gammaproteobacteria													Escherichia	1MVDK@1224,1RR0T@1236,COG3039@1,COG3039@2	NA|NA|NA	L	COG3039 Transposase and inactivated derivatives IS5 family
b2193	316407.85675300	2.5e-110	404.8	Escherichia	narP	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K07685	ko02020,map02020	M00472			ko00000,ko00001,ko00002,ko02022				Escherichia	1Q7GF@1224,1RWWU@1236,3XM7A@561,COG2197@1,COG2197@2	NA|NA|NA	K	Nitrate nitrite response regulator
b2194	198214.SF2278	6.5e-193	679.9	Gammaproteobacteria													Escherichia	1MZZ5@1224,1S9DV@1236,COG3088@1,COG3088@2,COG4235@1,COG4235@2	NA|NA|NA	P	subunit of a heme lyase
b2195	155864.EDL933_3360	6e-105	386.7	Escherichia	dsbE	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567		ko:K02199					ko00000,ko03110				Escherichia	1RI3N@1224,1S5YV@1236,3XN48@561,COG0526@1,COG0526@2	NA|NA|NA	O	Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme
b2196	316407.85675303	0.0	1267.7	Escherichia	ccmF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564		ko:K02198					ko00000,ko02000	9.B.14.1			Escherichia	1MUQS@1224,1RMY5@1236,3XMDT@561,COG1138@1,COG1138@2	NA|NA|NA	O	Cytochrome c-type biogenesis protein
b2197	155864.EDL933_3362	3.8e-84	317.4	Escherichia	ccmE	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015886,GO:0016020,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051181,GO:0051234,GO:0065003,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097159,GO:0098552,GO:0098567,GO:1901363,GO:1901564,GO:1901678		ko:K02197					ko00000			iSSON_1240.SSON_2255	Escherichia	1RHN5@1224,1S5VA@1236,3XPHZ@561,COG2332@1,COG2332@2	NA|NA|NA	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
b2198	155864.EDL933_3363	7.1e-27	125.9	Escherichia	ccmD	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678		ko:K02196	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1.107		iB21_1397.B21_02084,iBWG_1329.BWG_1971,iE2348C_1286.E2348C_2342,iEC042_1314.EC042_2439,iEC55989_1330.EC55989_2451,iECABU_c1320.ECABU_c25320,iECBD_1354.ECBD_1462,iECB_1328.ECB_02125,iECDH10B_1368.ECDH10B_2355,iECDH1ME8569_1439.ECDH1ME8569_2133,iECD_1391.ECD_02125,iECED1_1282.ECED1_2663,iECH74115_1262.ECH74115_3335,iECIAI1_1343.ECIAI1_2280,iECIAI39_1322.ECIAI39_2336,iECNA114_1301.ECNA114_2290,iECO103_1326.ECO103_2673,iECO111_1330.ECO111_2934,iECO26_1355.ECO26_3124,iECOK1_1307.ECOK1_2432,iECP_1309.ECP_2238,iECS88_1305.ECS88_2345,iECSE_1348.ECSE_2466,iECSF_1327.ECSF_2079,iECSP_1301.ECSP_3077,iECUMN_1333.ECUMN_2533,iECs_1301.ECs3087,iEKO11_1354.EKO11_1558,iETEC_1333.ETEC_2332,iEcDH1_1363.EcDH1_1461,iEcE24377_1341.EcE24377A_2497,iEcHS_1320.EcHS_A2336,iEcSMS35_1347.EcSMS35_2346,iEcolC_1368.EcolC_1452,iJO1366.b2198,iLF82_1304.LF82_0276,iNRG857_1313.NRG857_11155,iSDY_1059.SDY_0880,iSFV_1184.SFV_2274,iSF_1195.SF2282,iSSON_1240.SSON_2256,iS_1188.S2412,iUMN146_1321.UM146_05815,iUMNK88_1353.UMNK88_2745,iUTI89_1310.UTI89_C2476,iY75_1357.Y75_RS11500,iZ_1308.Z3455,ic_1306.c2735	Escherichia	1NGBM@1224,1SGGH@1236,3XPYN@561,COG3114@1,COG3114@2	NA|NA|NA	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
b2199	155864.EDL933_3364	3.2e-138	497.7	Escherichia	ccmC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0071944		ko:K02195	ko02010,map02010	M00259			ko00000,ko00001,ko00002,ko02000	3.A.1.107		iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736	Escherichia	1MU61@1224,1RP3R@1236,3XMMH@561,COG0755@1,COG0755@2	NA|NA|NA	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
b2200	155864.EDL933_3365	1.2e-88	332.8	Escherichia	ccmB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K02194	ko02010,map02010	M00259			ko00000,ko00001,ko00002,ko02000	3.A.1.107		iECO111_1330.ECO111_2936	Escherichia	1NJB0@1224,1RRFJ@1236,3XMNW@561,COG2386@1,COG2386@2	NA|NA|NA	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
b2201	316407.85675308	2.1e-114	418.3	Escherichia	ccmA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.41	ko:K02193	ko02010,map02010	M00259			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107		iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479	Escherichia	1MZPC@1224,1S3R2@1236,3XPCV@561,COG4133@1,COG4133@2	NA|NA|NA	O	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system
b2202	155864.EDL933_3367	7.9e-119	433.0	Escherichia	napC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0044464,GO:0045333,GO:0055114,GO:0071944		ko:K02569					ko00000			iEcolC_1368.EcolC_1448	Escherichia	1MWV2@1224,1RQ9A@1236,3XNSB@561,COG3005@1,COG3005@2	NA|NA|NA	C	Mediates electron flow from quinones to the NapAB complex
b2203	155864.EDL933_3368	8e-84	316.2	Escherichia	napB	GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0044237,GO:0045333,GO:0055114		ko:K02568	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798	RC02812	ko00000,ko00001,ko00002			iAF1260.b2203,iBWG_1329.BWG_1976,iE2348C_1286.E2348C_2347,iECDH10B_1368.ECDH10B_2360,iECDH1ME8569_1439.ECDH1ME8569_2138,iECED1_1282.ECED1_2668,iECH74115_1262.ECH74115_3340,iECIAI39_1322.ECIAI39_2341,iECNA114_1301.ECNA114_2295,iECOK1_1307.ECOK1_2437,iECP_1309.ECP_2244,iECS88_1305.ECS88_2350,iECSF_1327.ECSF_2084,iECSP_1301.ECSP_3082,iECUMN_1333.ECUMN_2538,iETEC_1333.ETEC_2337,iEcDH1_1363.EcDH1_1456,iEcolC_1368.EcolC_1447,iG2583_1286.G2583_2744,iJO1366.b2203,iLF82_1304.LF82_1453,iNRG857_1313.NRG857_11180,iSFV_1184.SFV_2279,iSF_1195.SF2287,iSFxv_1172.SFxv_2521,iS_1188.S2417,iUMN146_1321.UM146_05790,iY75_1357.Y75_RS11525	Escherichia	1RHGD@1224,1S84V@1236,3XQKT@561,COG3043@1,COG3043@2	NA|NA|NA	C	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB
b2204	316407.85675311	5e-167	593.6	Escherichia	napH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02574					ko00000			iEcSMS35_1347.EcSMS35_2352	Escherichia	1MWR5@1224,1RQ1I@1236,3XNDP@561,COG0348@1,COG0348@2	NA|NA|NA	C	ferredoxin-type protein, NapH
b2205	198214.SF2289	8.4e-133	479.6	Gammaproteobacteria													Escherichia	1N9WY@1224,1RNHT@1236,COG0437@1,COG0437@2	NA|NA|NA	C	Ferredoxin-type protein
b2206	316407.85675313	0.0	1719.9	Escherichia	napA	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0008940,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016661,GO:0030151,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114		ko:K02567	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_2447,iECABU_c1320.ECABU_c25400,iECO103_1326.ECO103_2681,iECSE_1348.ECSE_2474,iECSF_1327.ECSF_2087,iECUMN_1333.ECUMN_2541,iEcHS_1320.EcHS_A2344,iEcolC_1368.EcolC_1444,iSSON_1240.SSON_2264,ic_1306.c2745	Escherichia	1NS3T@1224,1RMWN@1236,3XNH6@561,COG0243@1,COG0243@2	NA|NA|NA	C	nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC
b2207	155864.EDL933_3372	9.2e-40	169.1	Escherichia	napD	GO:0003674,GO:0005048,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032879,GO:0032880,GO:0033218,GO:0042277,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0051049,GO:0051051,GO:0051223,GO:0051224,GO:0065007,GO:0070201,GO:0090087,GO:1904950		ko:K02570					ko00000				Escherichia	1N6UA@1224,1SCSX@1236,3XQ4H@561,COG3062@1,COG3062@2	NA|NA|NA	P	Plays a role in the correct assembly of subunits of the periplasmic NapAB enzyme
b2208	155864.EDL933_3373	1.8e-97	361.7	Escherichia	napF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0044424,GO:0044464,GO:0050896		ko:K02572					ko00000				Escherichia	1N09Y@1224,1S4EB@1236,3XMR9@561,COG1145@1,COG1145@2,COG1149@1,COG1149@2	NA|NA|NA	C	ferredoxin-type protein NapF
b2209	316407.1736850	2.9e-87	327.8	Escherichia	eco	GO:0003674,GO:0004857,GO:0004866,GO:0004867,GO:0005575,GO:0005623,GO:0008150,GO:0009892,GO:0010466,GO:0010605,GO:0010951,GO:0019222,GO:0030162,GO:0030234,GO:0030288,GO:0030313,GO:0030414,GO:0031323,GO:0031324,GO:0031975,GO:0032268,GO:0032269,GO:0042597,GO:0043086,GO:0044092,GO:0044464,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0080090,GO:0098772		ko:K08276					ko00000				Escherichia	1MZEN@1224,1S6Y9@1236,3XP1A@561,COG4574@1,COG4574@2	NA|NA|NA	M	General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases
b2210	316407.1736851	2.3e-311	1074.3	Escherichia	mqo	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008924,GO:0009898,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016901,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:1901265,GO:1901363	1.1.5.4	ko:K00116	ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011	R00360,R00361,R01257	RC00031	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2355,iEC55989_1330.EC55989_2465	Escherichia	1MUCC@1224,1RRBV@1236,3XPAI@561,COG0579@1,COG0579@2	NA|NA|NA	C	malate dehydrogenase (menaquinone) activity
b2211	316407.1736852	2.7e-307	1060.4	Escherichia	yojI	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0006810,GO:0008144,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0017076,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0044425,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K06159	ko02010,map02010				ko00000,ko00001,ko02000	3.A.1.113.3			Escherichia	1MVIC@1224,1RMYK@1236,3XMBM@561,COG4615@1,COG4615@2	NA|NA|NA	P	ATP-binding
b2212	316407.1736853	3.4e-128	464.2	Escherichia	alkB	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008198,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016705,GO:0016706,GO:0032451,GO:0033554,GO:0034641,GO:0035510,GO:0035511,GO:0035513,GO:0035515,GO:0035552,GO:0035553,GO:0042245,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043734,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044728,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051213,GO:0051716,GO:0055114,GO:0070579,GO:0070988,GO:0070989,GO:0071704,GO:0080111,GO:0090304,GO:0140098,GO:1901360	1.14.11.33	ko:K03919					ko00000,ko01000,ko03400				Escherichia	1N5HB@1224,1S23P@1236,3XN90@561,COG3145@1,COG3145@2	NA|NA|NA	L	Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents)
b2213	316407.1736854	2.6e-202	711.1	Escherichia	ada	GO:0001130,GO:0003674,GO:0003700,GO:0003824,GO:0003908,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016740,GO:0016741,GO:0018125,GO:0018193,GO:0018198,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044728,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070988,GO:0071704,GO:0080090,GO:0080111,GO:0090304,GO:0140110,GO:1901360,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	2.1.1.63	ko:K10778					ko00000,ko01000,ko03000,ko03400				Escherichia	1N2YQ@1224,1RPR3@1236,3XPAX@561,COG0350@1,COG0350@2,COG2169@1,COG2169@2	NA|NA|NA	K	Involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6-methylguanine (O6- MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism, although the methyl transfer occurs onto a different cysteine residue (Cys-38). Cannot demethylate the other diastereomer, Rp- methylphosphotriester. This is a suicide reaction the enzyme is irreversibly inactivated
b2214	155864.EDL933_3380	4.6e-199	700.3	Escherichia	apbE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016740,GO:0017013,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0031975,GO:0036094,GO:0036211,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:0098552,GO:0098567,GO:1901265,GO:1901363,GO:1901564	2.7.1.180	ko:K03734					ko00000,ko01000				Escherichia	1MW6K@1224,1RNMZ@1236,3XN11@561,COG1477@1,COG1477@2	NA|NA|NA	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
b2215	316407.1736856	1e-212	745.7	Escherichia	ompC	GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0010876,GO:0015711,GO:0015748,GO:0015914,GO:0016020,GO:0016021,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0033036,GO:0033554,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071702,GO:0071944		ko:K09475	ko01501,ko02020,map01501,map02020				ko00000,ko00001,ko02000	1.B.1.1.3		iEC042_1314.EC042_2456,iUMNK88_1353.UMNK88_2764	Escherichia	1MVRY@1224,1RNBS@1236,3XPDX@561,COG3203@1,COG3203@2	NA|NA|NA	M	Forms pores that allow passive diffusion of small molecules across the outer membrane
b2216	316407.1736857	0.0	1725.3	Escherichia	rcsD	GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009927,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07676	ko02020,ko02026,map02020,map02026	M00474			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1MXQG@1224,1RQ18@1236,3XNSS@561,COG0642@1,COG0642@2,COG2198@1,COG2198@2	NA|NA|NA	T	Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB
b2217	1114922.CIFAM_02_01580	4.8e-114	417.2	Citrobacter													Escherichia	1MW84@1224,1RNK3@1236,3WXP4@544,COG2197@1,COG2197@2	NA|NA|NA	K	Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions
b2218	511145.b2218	0.0	1872.1	Escherichia	rcsC	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042710,GO:0043170,GO:0043412,GO:0044010,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051716,GO:0065007,GO:0071214,GO:0071470,GO:0071704,GO:0071944,GO:0104004,GO:0140096,GO:1901564	2.7.13.3	ko:K07677	ko02020,ko02026,map02020,map02026	M00474			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1NRP8@1224,1RQCU@1236,3XMTU@561,COG0642@1,COG0784@1,COG0784@2,COG2205@2	NA|NA|NA	T	PhoQ Sensor
b2219	316407.1736874	0.0	1173.3	Escherichia	atoS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K07710	ko02020,map02020	M00500			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1NTTH@1224,1T26Z@1236,3XNFE@561,COG3852@1,COG3852@2	NA|NA|NA	T	Member of the two-component regulatory system AtoS AtoC. In the presence of acetoacetate, AtoS AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoS is a membrane-associated kinase that phosphorylates and activates AtoC in response to environmental signals
b2220	1440052.EAKF1_ch3768c	1.2e-260	905.2	Escherichia	atoC	GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K07714	ko02020,map02020	M00500			ko00000,ko00001,ko00002,ko02022				Escherichia	1MU0N@1224,1RMCK@1236,3XP3S@561,COG2204@1,COG2204@2	NA|NA|NA	T	Member of the two-component regulatory system AtoS AtoC. In the presence of acetoacetate, AtoS AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, functions as a post- translational regulator that inhibits polyamine biosynthesis via regulation of ornithine decarboxylase (ODC)
b2221	316407.1736876	1e-119	436.0	Escherichia	atoD		2.8.3.8,2.8.3.9	ko:K01034	ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020		R01179,R01359,R01365,R07832	RC00012,RC00014	ko00000,ko00001,ko01000				Escherichia	1MVEI@1224,1RNXB@1236,3XMT4@561,COG1788@1,COG1788@2	NA|NA|NA	I	acetate CoA-transferase activity
b2222	316407.1736877	4.5e-120	437.2	Escherichia	atoA	GO:0003674,GO:0003824,GO:0008410,GO:0008775,GO:0016740,GO:0016782	2.8.3.8,2.8.3.9	ko:K01035	ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020		R01179,R01359,R01365,R07832	RC00012,RC00014	ko00000,ko00001,ko01000			iSSON_1240.SSON_2281	Escherichia	1RA4V@1224,1RP21@1236,3XM41@561,COG2057@1,COG2057@2	NA|NA|NA	I	acetate CoA-transferase activity
b2223	316407.1736878	9.1e-245	852.4	Escherichia	atoE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02106	ko02020,map02020				ko00000,ko00001	2.A.73.1		iECUMN_1333.ECUMN_2561	Escherichia	1MV5A@1224,1RMTZ@1236,3XN8R@561,COG2031@1,COG2031@2	NA|NA|NA	I	Short chain fatty acid transporter
b2224	316407.1736879	5.9e-211	740.0	Escherichia	atoB	GO:0003674,GO:0003824,GO:0003985,GO:0003988,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016043,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0019395,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0032787,GO:0034440,GO:0042737,GO:0042802,GO:0043436,GO:0043438,GO:0043442,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046459,GO:0046950,GO:0046952,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072329,GO:1901568,GO:1901569,GO:1901575,GO:1902224	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147			iAF1260.b2224,iB21_1397.B21_02110,iBWG_1329.BWG_1998,iEC042_1314.EC042_2465,iECBD_1354.ECBD_1435,iECB_1328.ECB_02151,iECDH10B_1368.ECDH10B_2382,iECDH1ME8569_1439.ECDH1ME8569_2159,iECD_1391.ECD_02151,iETEC_1333.ETEC_2358,iEcDH1_1363.EcDH1_1434,iEcolC_1368.EcolC_1426,iJO1366.b2224,iJR904.b2224,iY75_1357.Y75_RS11660	Escherichia	1MU5G@1224,1RM93@1236,3XMFA@561,COG0183@1,COG0183@2	NA|NA|NA	I	acetoacetic acid catabolic process
b2225	316407.85675318	3.7e-145	520.8	Escherichia	yfaP												Escherichia	1R801@1224,1RYMC@1236,3XNKU@561,COG4676@1,COG4676@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2135)
b2226	316407.85675319	0.0	1110.1	Escherichia	yfaQ												Escherichia	1QBHH@1224,1S0FA@1236,3XNJC@561,COG5445@1,COG5445@2	NA|NA|NA	S	Stage II sporulation protein
b4500	469008.B21_02113	0.0	3023.4	Escherichia	JD73_19595			ko:K06894					ko00000				Escherichia	1MV7J@1224,1S1TU@1236,3XMWZ@561,COG2373@1,COG2373@2	NA|NA|NA	S	Alpha-2-Macroglobulin
b2229	155864.EDL933_3390	7.9e-122	443.0	Escherichia	yfaT			ko:K09934					ko00000				Escherichia	1R6VA@1224,1RXXS@1236,3XNZE@561,COG3234@1,COG3234@2	NA|NA|NA	S	Protein of unknown function (DUF1175)
b2230	316407.1799574	0.0	1122.5	Escherichia	yfaA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MY31@1224,1S1N1@1236,3XNSJ@561,COG4685@1,COG4685@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2138)
b2231	198214.SF2311	0.0	1600.9	Gammaproteobacteria													Escherichia	1MUGG@1224,1RN03@1236,COG0188@1,COG0188@2	NA|NA|NA	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
b2232	316407.1799576	1.1e-138	499.2	Escherichia	ubiG	GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2376	Escherichia	1MU89@1224,1RMV7@1236,3XMKY@561,COG2227@1,COG2227@2	NA|NA|NA	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway
b2233	316407.85675321	0.0	2236.8	Escherichia	yfaL	GO:0005575,GO:0005576,GO:0005623,GO:0007155,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009986,GO:0009987,GO:0022610,GO:0031589,GO:0042597,GO:0042710,GO:0043708,GO:0043709,GO:0044010,GO:0044464,GO:0044764,GO:0050896,GO:0051704,GO:0090605,GO:0090609		ko:K07279					ko00000,ko02000,ko02044	1.B.12			Escherichia	1R9B8@1224,1S1YA@1236,3XQFF@561,COG3468@1,COG3468@2	NA|NA|NA	MU	cell adhesion involved in single-species biofilm formation
b2234	316407.1799581	0.0	1420.2	Escherichia	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0015949,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400			iSDY_1059.SDY_2428	Escherichia	1MUJ8@1224,1RMPV@1236,3XP46@561,COG0209@1,COG0209@2	NA|NA|NA	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
b2235	155864.EDL933_3396	3.4e-216	757.3	Escherichia	nrdB	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0015949,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400			iAPECO1_1312.APECO1_4325	Escherichia	1MWUS@1224,1RMJC@1236,3XMHI@561,COG0208@1,COG0208@2	NA|NA|NA	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis
b2236	199310.c2778	1.3e-43	181.8	Escherichia	yfaE	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0006124,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0019538,GO:0022900,GO:0030091,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071704,GO:1901564		ko:K11107					ko00000				Escherichia	1N6XY@1224,1SC8M@1236,3XPYF@561,COG1018@1,COG1018@2	NA|NA|NA	C	ferredoxin metabolic process
b2237	316407.1799584	2.5e-123	448.0	Escherichia	inaA												Escherichia	1N21R@1224,1RYF7@1236,3XQEJ@561,COG3642@1,COG3642@2	NA|NA|NA	T	May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other
b2238	316407.1799585	8.8e-30	135.6	Bacteria													Escherichia	COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
b2239	316407.1799586	4.6e-210	736.9	Escherichia	glpQ	GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008081,GO:0008889,GO:0016787,GO:0016788,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872	3.1.4.46	ko:K01126	ko00564,map00564		R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_2331,iECSF_1327.ECSF_2119	Escherichia	1MVWZ@1224,1RRBP@1236,3XP14@561,COG0584@1,COG0584@2	NA|NA|NA	C	glycerophosphoryl diester phosphodiesterase
b2240	316407.1799587	3.7e-249	867.1	Escherichia	glpT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0008643,GO:0015075,GO:0015103,GO:0015114,GO:0015144,GO:0015166,GO:0015168,GO:0015291,GO:0015297,GO:0015301,GO:0015315,GO:0015318,GO:0015527,GO:0015698,GO:0015711,GO:0015748,GO:0015791,GO:0015793,GO:0015794,GO:0015850,GO:0016020,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035435,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:0099516,GO:1901264,GO:1901618		ko:K02445					ko00000,ko02000	2.A.1.4.3		iECH74115_1262.ECH74115_3377,iECIAI39_1322.ECIAI39_2383,iECSP_1301.ECSP_3115,iECs_1301.ECs3125,iEcSMS35_1347.EcSMS35_2392,iG2583_1286.G2583_2780,iSFV_1184.SFV_2312,iZ_1308.Z3498	Escherichia	1MX4V@1224,1RMB3@1236,3XNBI@561,COG2271@1,COG2271@2	NA|NA|NA	P	glycerol-phosphate:inorganic phosphate antiporter activity
b2241	155864.EDL933_3405	0.0	1086.2	Escherichia	glpA	GO:0000166,GO:0003674,GO:0003824,GO:0004368,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006072,GO:0006091,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016901,GO:0019637,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046168,GO:0046434,GO:0048037,GO:0050660,GO:0050662,GO:0052646,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901136,GO:1901265,GO:1901363,GO:1901575	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110		R00848	RC00029	ko00000,ko00001,ko01000			iSDY_1059.SDY_2436	Escherichia	1MUMY@1224,1RUEK@1236,3XMZ8@561,COG0578@1,COG0578@2	NA|NA|NA	C	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
b2242	316407.1799589	2.1e-243	847.8	Escherichia	glpB	GO:0000166,GO:0003674,GO:0003824,GO:0004368,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006072,GO:0006091,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009061,GO:0009987,GO:0010181,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016901,GO:0019637,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046168,GO:0046434,GO:0048037,GO:0050662,GO:0052646,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901265,GO:1901363,GO:1901575	1.1.5.3	ko:K00112	ko00564,ko01110,map00564,map01110		R00848	RC00029	ko00000,ko00001,ko01000			iB21_1397.B21_02127,iEC042_1314.EC042_2485,iECBD_1354.ECBD_1418,iECB_1328.ECB_02168,iECD_1391.ECD_02168,iECUMN_1333.ECUMN_2582,iEcHS_1320.EcHS_A2383,iUMNK88_1353.UMNK88_2792	Escherichia	1MU3K@1224,1RP77@1236,3XN7A@561,COG3075@1,COG3075@2	NA|NA|NA	C	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
b2243	155864.EDL933_3407	1.8e-236	824.7	Escherichia	glpC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944	1.1.5.3	ko:K00113	ko00564,ko01110,map00564,map01110		R00848	RC00029	ko00000,ko00001,ko01000				Escherichia	1MWTK@1224,1RQ9M@1236,3XP8B@561,COG0247@1,COG0247@2	NA|NA|NA	C	Anaerobic glycerol-3-phosphate dehydrogenase subunit C
b2244	316407.1799591	1.9e-169	601.7	Escherichia	yfaD												Escherichia	1MUSP@1224,1RNUW@1236,3XNSZ@561,COG5464@1,COG5464@2	NA|NA|NA	S	Putative transposase, YhgA-like
b4543	362663.ECP_2287	4.5e-25	119.8	Bacteria													Escherichia	COG5464@1,COG5464@2	NA|NA|NA	S	double-stranded DNA endodeoxyribonuclease activity
b2245	316407.85675322	8.2e-148	529.6	Escherichia	rhmA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016151,GO:0016829,GO:0016830,GO:0016832,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0071704	4.1.2.53	ko:K12660	ko00051,ko01120,map00051,map01120		R02261	RC00307,RC00435	ko00000,ko00001,ko01000			iSBO_1134.SBO_2049	Escherichia	1MUSG@1224,1RMWJ@1236,3XNDD@561,COG3836@1,COG3836@2	NA|NA|NA	H	Catalyzes the reversible retro-aldol cleavage of 2-keto- 3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde
b2246	316407.1799599	1.6e-233	815.1	Escherichia	yfaV	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944										iAPECO1_1312.APECO1_4315,iUTI89_1310.UTI89_C2528,ic_1306.c2788	Escherichia	1MUEK@1224,1RMB4@1236,3XNKV@561,COG2271@1,COG2271@2	NA|NA|NA	P	transmembrane transport
b2247	316407.1799600	2.1e-243	847.8	Escherichia	rhmD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016829,GO:0016835,GO:0016836,GO:0042802,GO:0050032	4.2.1.90	ko:K12661	ko00051,ko01120,map00051,map01120		R03774	RC00543	ko00000,ko00001,ko01000				Escherichia	1MW5B@1224,1RSMH@1236,3XQKA@561,COG4948@1,COG4948@2	NA|NA|NA	H	Catalyzes the dehydration of L-rhamnonate to 2-keto-3- deoxy-L-rhamnonate (KDR)
b2248	316407.1799601	1.4e-144	518.8	Escherichia	JD73_19475	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141											Escherichia	1R5G3@1224,1RSB1@1236,3XP94@561,COG1414@1,COG1414@2	NA|NA|NA	K	Transcriptional regulator
b2249	316407.1799602	7.1e-228	796.2	Escherichia	yfaY												Escherichia	1QUB2@1224,1RNXG@1236,3XN9H@561,COG1058@1,COG1058@2	NA|NA|NA	S	Probable molybdopterin binding domain
b2250	316407.85675323	2.2e-88	331.6	Escherichia	yfaZ	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944											Escherichia	1RDW5@1224,1S3Q0@1236,29PXB@1,30AVP@2,3XMZE@561	NA|NA|NA	S	YfaZ precursor
b2251	316407.1799603	6.8e-77	293.1	Escherichia	nudI	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0047429,GO:0047840		ko:K12944					ko00000,ko01000			iECABU_c1320.ECABU_c25850,iECED1_1282.ECED1_2717,iECP_1309.ECP_2294,iECSF_1327.ECSF_2131,ic_1306.c2793	Escherichia	1R9WD@1224,1S3YH@1236,3XPRF@561,COG0494@1,COG0494@2	NA|NA|NA	L	Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP)
b2252	316407.1799604	1.3e-110	405.6	Escherichia	ais												Escherichia	1R8NR@1224,1S1BP@1236,3XNTM@561,COG0406@1,COG0406@2	NA|NA|NA	M	Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core
b2253	316407.85675324	8.9e-220	769.2	Escherichia	arnB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0008483,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:0099620,GO:1901363	2.6.1.87	ko:K07806	ko00520,ko01503,ko02020,map00520,map01503,map02020	M00721,M00761	R07659	RC00006,RC01514	ko00000,ko00001,ko00002,ko01000,ko01005,ko01007			iSFxv_1172.SFxv_2574	Escherichia	1MUPN@1224,1RMCS@1236,3XMQ3@561,COG0399@1,COG0399@2	NA|NA|NA	M	Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides
b2254	316407.1799606	3.2e-178	630.9	Escherichia	arnC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0044464,GO:0071944,GO:0099621	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	iAPECO1_1312.APECO1_4307,iE2348C_1286.E2348C_2398,iECABU_c1320.ECABU_c25880,iECED1_1282.ECED1_2720,iECOK1_1307.ECOK1_2490,iECP_1309.ECP_2297,iECS88_1305.ECS88_2403,iLF82_1304.LF82_0138,iNRG857_1313.NRG857_11430,iUMN146_1321.UM146_05530,iUTI89_1310.UTI89_C2536,ic_1306.c2796	Escherichia	1MWE5@1224,1RPCE@1236,3XPBE@561,COG0463@1,COG0463@2	NA|NA|NA	I	Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides
b2255	316407.1799607	0.0	1364.0	Escherichia	arnA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006040,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016741,GO:0016742,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0022607,GO:0033319,GO:0033320,GO:0034214,GO:0034641,GO:0034654,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046349,GO:0046483,GO:0046677,GO:0048037,GO:0048040,GO:0050662,GO:0050896,GO:0051259,GO:0051287,GO:0055086,GO:0055114,GO:0065003,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:0099618,GO:0099619,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:2001313,GO:2001315	1.1.1.305,2.1.2.13	ko:K10011	ko00520,ko01503,map00520,map01503	M00721,M00761	R07658,R07660	RC00026,RC01575,RC01812	ko00000,ko00001,ko00002,ko01000,ko01005			iSFV_1184.SFV_2325	Escherichia	1MXKV@1224,1RNJD@1236,3XPGM@561,COG0223@1,COG0223@2,COG0451@1,COG0451@2	NA|NA|NA	I	Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides
b2256	316407.85675325	8.5e-178	629.4	Escherichia	arnD	GO:0005575,GO:0008150,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0042221,GO:0050896		ko:K13014	ko00520,ko01503,map00520,map01503	M00721,M00761	R07662	RC00323,RC01575	ko00000,ko00001,ko00002,ko01000,ko01005			iB21_1397.B21_02141,iBWG_1329.BWG_2029,iEC042_1314.EC042_2499,iECBD_1354.ECBD_1403,iECB_1328.ECB_02182,iECDH10B_1368.ECDH10B_2416,iECDH1ME8569_1439.ECDH1ME8569_2192,iECD_1391.ECD_02182,iECO103_1326.ECO103_2722,iECO111_1330.ECO111_3006,iECO26_1355.ECO26_3246,iECUMN_1333.ECUMN_2597,iECW_1372.ECW_m2447,iEKO11_1354.EKO11_1508,iETEC_1333.ETEC_2390,iEcDH1_1363.EcDH1_1402,iEcHS_1320.EcHS_A2401,iEcolC_1368.EcolC_1393,iJO1366.b2256,iSFV_1184.SFV_2326,iSSON_1240.SSON_2317,iUMNK88_1353.UMNK88_2808,iWFL_1372.ECW_m2447,iY75_1357.Y75_RS11830	Escherichia	1N8Q4@1224,1RQ0R@1236,3XPB4@561,COG0726@1,COG0726@2	NA|NA|NA	G	Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides
b2257	316407.85675326	2.3e-306	1057.4	Escherichia	arnT	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016763,GO:0033692,GO:0034637,GO:0034645,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.2.43	ko:K07264	ko01503,map01503	M00721	R09773,R09774,R09781	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005			iEcHS_1320.EcHS_A2402	Escherichia	1NMIZ@1224,1RMA2@1236,3XN53@561,COG1807@1,COG1807@2	NA|NA|NA	I	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides
b4544	316407.85675327	2.6e-55	221.1	Escherichia	arnE	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944		ko:K12962	ko01503,map01503	M00721			ko00000,ko00001,ko00002,ko01005,ko02000	2.A.7.22		iEC55989_1330.EC55989_2505,iECABU_c1320.ECABU_c25920,iLF82_1304.LF82_3058,iNRG857_1313.NRG857_11450,ic_1306.c2800	Escherichia	1MY82@1224,1SYBA@1236,3XPW7@561,COG2076@1,COG2076@2	NA|NA|NA	P	Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane
b2258	316407.85675328	3e-63	247.7	Escherichia	arnF	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944		ko:K12963	ko01503,map01503	M00721			ko00000,ko00001,ko00002,ko01005	2.A.7		iECUMN_1333.ECUMN_2601,iSF_1195.SF2337,iS_1188.S2471	Escherichia	1N7ZX@1224,1SCDW@1236,3XPPS@561,COG2076@1,COG2076@2	NA|NA|NA	P	Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane
b2259	316407.85675329	9.6e-45	185.7	Escherichia	pmrD			ko:K19238	ko01503,map01503				ko00000,ko00001				Escherichia	1NBZ4@1224,1SDH3@1236,2EDNI@1,337I9@2,3XR5G@561	NA|NA|NA	S	Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance in some natural isolates
b2260	316407.1799614	6e-268	929.5	Escherichia	menE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0008150,GO:0008152,GO:0008756,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016043,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0022607,GO:0042180,GO:0042181,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901576,GO:1901661,GO:1901663	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_2354,iECSF_1327.ECSF_2141,iEcE24377_1341.EcE24377A_2556,iEcHS_1320.EcHS_A2406,iLF82_1304.LF82_1314,iNRG857_1313.NRG857_11465	Escherichia	1MW0Y@1224,1RN35@1236,3XNGV@561,COG0318@1,COG0318@2	NA|NA|NA	H	Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily
b2261	316407.85675330	7.2e-183	646.4	Escherichia	menC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2406,iSbBS512_1146.SbBS512_E2640	Escherichia	1MV33@1224,1RRC0@1236,3XNDA@561,COG1441@1,COG1441@2	NA|NA|NA	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)
b2262	199310.c2805	5e-167	593.6	Escherichia	menB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071890,GO:1901576,GO:1901661,GO:1901663	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000				Escherichia	1QTZ2@1224,1T1TZ@1236,3XMUF@561,COG0447@1,COG0447@2	NA|NA|NA	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
b2263	316407.85675331	6.8e-144	516.5	Escherichia	menH	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016787,GO:0016829,GO:0016835,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0070205,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_4298,iEC55989_1330.EC55989_2511,iECO103_1326.ECO103_2730,iECOK1_1307.ECOK1_2500,iECS88_1305.ECS88_2414,iETEC_1333.ETEC_2398,iEcE24377_1341.EcE24377A_2559,iSBO_1134.SBO_2300,iUMN146_1321.UM146_05480,iUTI89_1310.UTI89_C2547	Escherichia	1R3WK@1224,1RQHH@1236,3XNH0@561,COG0596@1,COG0596@2	NA|NA|NA	H	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC)
b2264	316407.85675332	0.0	1132.1	Escherichia	menD	GO:0003674,GO:0003824,GO:0005488,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016744,GO:0019842,GO:0030976,GO:0036094,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070204,GO:0071704,GO:0097159,GO:1901363,GO:1901576,GO:1901661,GO:1901663,GO:1901681	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000			iSBO_1134.SBO_2301	Escherichia	1MVMZ@1224,1RNRS@1236,3XMUB@561,COG1165@1,COG1165@2	NA|NA|NA	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
b2265	316407.1799622	6.4e-251	872.8	Escherichia	menF	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004049,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008909,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009233,GO:0009234,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042180,GO:0042181,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046872,GO:0050486,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901661,GO:1901663,GO:1902494	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c26010,iECIAI39_1322.ECIAI39_2413,ic_1306.c2809	Escherichia	1MVB7@1224,1RNSR@1236,3XPGQ@561,COG1169@1,COG1169@2	NA|NA|NA	H	Catalyzes the conversion of chorismate to isochorismate
b2266	155864.EDL933_3432	3.7e-48	197.2	Escherichia	elaB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033554,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K05594					ko00000				Escherichia	1RIDP@1224,1S68F@1236,3XPV9@561,COG4575@1,COG4575@2	NA|NA|NA	S	ribosome binding
b2267	198214.SF2346	1.5e-85	322.0	Gammaproteobacteria													Escherichia	1MZHA@1224,1S9IF@1236,COG2153@1,COG2153@2	NA|NA|NA	S	Acyltransferase
b2268	198214.SF2347	8.7e-178	629.4	Gammaproteobacteria													Escherichia	1Q4PW@1224,1RR5K@1236,COG1234@1,COG1234@2	NA|NA|NA	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA
b2269	316407.85675334	2.4e-228	797.7	Gammaproteobacteria													Escherichia	1N09I@1224,1SC0W@1236,COG5160@1,COG5160@2	NA|NA|NA	O	Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is
b2270	316407.85675335	6.4e-299	1032.7	Escherichia	yfbK			ko:K07114					ko00000,ko02000	1.A.13.2.2,1.A.13.2.3			Escherichia	1MUTS@1224,1RQPC@1236,3XNXI@561,COG2304@1,COG2304@2	NA|NA|NA	S	von Willebrand factor type A domain
b2271	316407.85675336	5.1e-184	650.2	Escherichia	yfbL												Escherichia	1MXZS@1224,1S0QR@1236,3XP3R@561,COG2234@1,COG2234@2	NA|NA|NA	S	Peptidase family M28
b2272	316407.85675337	8.4e-90	336.3	Escherichia	yfbM												Escherichia	1NADM@1224,1SFMG@1236,29094@1,2ZMYT@2,3XNXP@561	NA|NA|NA	S	Domain of unknown function (DUF1877)
b2273	316407.85675338	2.1e-134	485.0	Gammaproteobacteria													Escherichia	1RDPT@1224,1S3W4@1236,29TMA@1,30EUU@2	NA|NA|NA		
b2274	316407.85675339	2e-81	308.1	Bacteria													Escherichia	2ERBJ@1,33IX7@2	NA|NA|NA		
b2275	316407.85675340	1.2e-168	599.0	Gammaproteobacteria													Escherichia	1RE64@1224,1S5GR@1236,COG0457@1,COG0457@2	NA|NA|NA	S	Tetratricopeptide repeat
b2276	155864.EDL933_3439	1.2e-261	908.7	Escherichia	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iEC042_1314.EC042_2517,iSbBS512_1146.SbBS512_E2652	Escherichia	1MV56@1224,1RPJB@1236,3XN8H@561,COG1007@1,COG1007@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
b2277	155864.EDL933_3440	1.6e-288	998.0	Escherichia	nuoM	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iSDY_1059.SDY_2473	Escherichia	1MV7V@1224,1RNI4@1236,3XMB8@561,COG1008@1,COG1008@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
b2278	316407.1799638	0.0	1180.6	Escherichia	nuoL	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015672,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0051179,GO:0051234,GO:0055085,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		e_coli_core.b2278,iAF1260.b2278,iBWG_1329.BWG_2052,iECDH10B_1368.ECDH10B_2440,iECDH1ME8569_1439.ECDH1ME8569_2215,iEcDH1_1363.EcDH1_1379,iJO1366.b2278,iJR904.b2278,iY75_1357.Y75_RS11945	Escherichia	1MW2M@1224,1RNKN@1236,3XQAB@561,COG1009@1,COG1009@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
b2279	1080067.BAZH01000028_gene1119	4.2e-28	130.6	Citrobacter													Escherichia	1RH0S@1224,1S6FN@1236,3WYKT@544,COG0713@1,COG0713@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
b2280	155864.EDL933_3443	1.2e-89	335.9	Escherichia	nuoJ	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		e_coli_core.b2280,iAF1260.b2280,iAPECO1_1312.APECO1_4285,iB21_1397.B21_02165,iBWG_1329.BWG_2054,iE2348C_1286.E2348C_2420,iEC042_1314.EC042_2521,iEC55989_1330.EC55989_2524,iECABU_c1320.ECABU_c26120,iECBD_1354.ECBD_1381,iECB_1328.ECB_02205,iECDH10B_1368.ECDH10B_2442,iECDH1ME8569_1439.ECDH1ME8569_2217,iECD_1391.ECD_02205,iECED1_1282.ECED1_2744,iECH74115_1262.ECH74115_3419,iECIAI1_1343.ECIAI1_2354,iECIAI39_1322.ECIAI39_2427,iECNA114_1301.ECNA114_2370,iECO103_1326.ECO103_2744,iECO111_1330.ECO111_3028,iECO26_1355.ECO26_3268,iECOK1_1307.ECOK1_2513,iECP_1309.ECP_2319,iECS88_1305.ECS88_2427,iECSE_1348.ECSE_2537,iECSF_1327.ECSF_2157,iECSP_1301.ECSP_3154,iECUMN_1333.ECUMN_2619,iECW_1372.ECW_m2468,iECs_1301.ECs3164,iEKO11_1354.EKO11_1487,iETEC_1333.ETEC_2415,iEcDH1_1363.EcDH1_1377,iEcE24377_1341.EcE24377A_2573,iEcHS_1320.EcHS_A2429,iEcSMS35_1347.EcSMS35_2434,iEcolC_1368.EcolC_1372,iJO1366.b2280,iJR904.b2280,iLF82_1304.LF82_1547,iNRG857_1313.NRG857_11545,iSBO_1134.SBO_2313,iSDY_1059.SDY_2476,iSFV_1184.SFV_2347,iSF_1195.SF2356,iSFxv_1172.SFxv_2600,iSSON_1240.SSON_2337,iS_1188.S2491,iSbBS512_1146.SbBS512_E2656,iUMN146_1321.UM146_05415,iUMNK88_1353.UMNK88_2830,iUTI89_1310.UTI89_C2560,iWFL_1372.ECW_m2468,iY75_1357.Y75_RS11955,iZ_1308.Z3539,ic_1306.c2821	Escherichia	1MWJV@1224,1S65T@1236,3XMGS@561,COG0839@1,COG0839@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
b2281	1440052.EAKF1_ch3700	5.8e-89	333.6	Escherichia	nuoI	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		e_coli_core.b2281,iAF1260.b2281,iAPECO1_1312.APECO1_4284,iB21_1397.B21_02166,iBWG_1329.BWG_2055,iE2348C_1286.E2348C_2421,iEC042_1314.EC042_2522,iEC55989_1330.EC55989_2525,iECABU_c1320.ECABU_c26130,iECBD_1354.ECBD_1380,iECB_1328.ECB_02206,iECDH10B_1368.ECDH10B_2443,iECDH1ME8569_1439.ECDH1ME8569_2218,iECD_1391.ECD_02206,iECED1_1282.ECED1_2745,iECH74115_1262.ECH74115_3420,iECIAI1_1343.ECIAI1_2355,iECIAI39_1322.ECIAI39_2428,iECNA114_1301.ECNA114_2371,iECO103_1326.ECO103_2745,iECO111_1330.ECO111_3029,iECO26_1355.ECO26_3269,iECOK1_1307.ECOK1_2514,iECP_1309.ECP_2320,iECS88_1305.ECS88_2428,iECSE_1348.ECSE_2538,iECSF_1327.ECSF_2158,iECSP_1301.ECSP_3155,iECUMN_1333.ECUMN_2620,iECW_1372.ECW_m2469,iECs_1301.ECs3165,iEKO11_1354.EKO11_1486,iETEC_1333.ETEC_2416,iEcDH1_1363.EcDH1_1376,iEcE24377_1341.EcE24377A_2574,iEcHS_1320.EcHS_A2430,iEcSMS35_1347.EcSMS35_2435,iEcolC_1368.EcolC_1371,iG2583_1286.G2583_2818,iJO1366.b2281,iJR904.b2281,iLF82_1304.LF82_1546,iNRG857_1313.NRG857_11550,iSBO_1134.SBO_2314,iSFV_1184.SFV_2348,iSF_1195.SF2357,iSFxv_1172.SFxv_2601,iS_1188.S2492,iSbBS512_1146.SbBS512_E2657,iUMN146_1321.UM146_05410,iUMNK88_1353.UMNK88_2831,iUTI89_1310.UTI89_C2561,iWFL_1372.ECW_m2469,iY75_1357.Y75_RS11960,iZ_1308.Z3540,ic_1306.c2822	Escherichia	1MV90@1224,1RN32@1236,3XMP4@561,COG1143@1,COG1143@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
b2282	155864.EDL933_3445	2.6e-180	637.9	Escherichia	nuoH	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Escherichia	1MU2R@1224,1RQE9@1236,3XNZP@561,COG1005@1,COG1005@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
b2283	316407.85675343	0.0	1847.0	Escherichia	nuoG	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iECs_1301.ECs3167,iG2583_1286.G2583_2820,iZ_1308.Z3542	Escherichia	1P8MN@1224,1RMUH@1236,3XM7D@561,COG1034@1,COG1034@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
b2284	1440052.EAKF1_ch3697	1.4e-269	934.9	Escherichia	nuoF	GO:0000166,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0010181,GO:0015980,GO:0016020,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0050662,GO:0051287,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Escherichia	1MV8F@1224,1RMUD@1236,3XNXF@561,COG1894@1,COG1894@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
b2285	1440052.EAKF1_ch3696	2.8e-93	347.8	Escherichia	nuoE	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0050136,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Escherichia	1MWS2@1224,1RN4C@1236,3XND0@561,COG1905@1,COG1905@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
b2286	316407.85675344	0.0	1242.6	Escherichia	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		iECDH10B_1368.ECDH10B_2448,iECDH1ME8569_1439.ECDH1ME8569_2223,iETEC_1333.ETEC_2421,iEcDH1_1363.EcDH1_1371,iUMNK88_1353.UMNK88_2836	Escherichia	1MVIN@1224,1RM98@1236,3XP7Y@561,COG0649@1,COG0649@2,COG0852@1,COG0852@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
b2287	1440052.EAKF1_ch3694	5.6e-126	456.8	Escherichia	nuoB	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0050136,GO:0051179,GO:0051234,GO:0051536,GO:0051539,GO:0051540,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1			Escherichia	1MUI2@1224,1RP4R@1236,3XMPW@561,COG0377@1,COG0377@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
b2288	155864.EDL933_3451	8.7e-75	286.2	Escherichia	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1		e_coli_core.b2288,iAF1260.b2288,iAPECO1_1312.APECO1_4277,iB21_1397.B21_02173,iBWG_1329.BWG_2062,iE2348C_1286.E2348C_2428,iEC042_1314.EC042_2529,iEC55989_1330.EC55989_2532,iECABU_c1320.ECABU_c26200,iECBD_1354.ECBD_1373,iECB_1328.ECB_02213,iECDH10B_1368.ECDH10B_2450,iECDH1ME8569_1439.ECDH1ME8569_2225,iECD_1391.ECD_02213,iECED1_1282.ECED1_2752,iECH74115_1262.ECH74115_3427,iECIAI1_1343.ECIAI1_2362,iECIAI39_1322.ECIAI39_2435,iECO103_1326.ECO103_2752,iECO26_1355.ECO26_3276,iECOK1_1307.ECOK1_2521,iECP_1309.ECP_2327,iECS88_1305.ECS88_2435,iECSE_1348.ECSE_2545,iECSP_1301.ECSP_3162,iECUMN_1333.ECUMN_2627,iECW_1372.ECW_m2476,iECs_1301.ECs3172,iEKO11_1354.EKO11_1479,iETEC_1333.ETEC_2423,iEcDH1_1363.EcDH1_1369,iEcE24377_1341.EcE24377A_2581,iEcHS_1320.EcHS_A2437,iEcSMS35_1347.EcSMS35_2442,iEcolC_1368.EcolC_1364,iG2583_1286.G2583_2825,iJO1366.b2288,iJR904.b2288,iLF82_1304.LF82_1539,iNRG857_1313.NRG857_11585,iSBO_1134.SBO_2321,iSDY_1059.SDY_2484,iSFV_1184.SFV_2355,iSF_1195.SF2364,iSFxv_1172.SFxv_2608,iSSON_1240.SSON_2345,iS_1188.S2499,iSbBS512_1146.SbBS512_E2664,iUMN146_1321.UM146_05375,iUTI89_1310.UTI89_C2568,iWFL_1372.ECW_m2476,iY75_1357.Y75_RS11995,ic_1306.c2829	Escherichia	1RGUT@1224,1S644@1236,3XPK3@561,COG0838@1,COG0838@2	NA|NA|NA	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
b2289	316407.85675346	1.9e-172	611.7	Escherichia	lrhA	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141											Escherichia	1PR6U@1224,1RQ7J@1236,3XMQ1@561,COG0583@1,COG0583@2	NA|NA|NA	K	Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon
b2290	198214.SF2366	3.7e-240	837.0	Gammaproteobacteria													Escherichia	1MW0Z@1224,1RN5B@1236,COG0436@1,COG0436@2	NA|NA|NA	E	in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor'
b2291	316407.85675347	1.3e-105	389.0	Escherichia	yfbR	GO:0002953,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0010139,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032262,GO:0034641,GO:0034654,GO:0042578,GO:0042802,GO:0043094,GO:0043167,GO:0043169,GO:0043173,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046078,GO:0046385,GO:0046483,GO:0046872,GO:0046914,GO:0050897,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.89	ko:K08722	ko00240,ko01100,map00240,map01100		R01569,R01664,R01968,R02088,R02102,R10776	RC00017	ko00000,ko00001,ko01000			iB21_1397.B21_02176,iEC55989_1330.EC55989_2535,iECBD_1354.ECBD_1368,iECB_1328.ECB_02216,iECD_1391.ECD_02216,iECH74115_1262.ECH74115_3430,iECIAI1_1343.ECIAI1_2365,iECIAI39_1322.ECIAI39_2438,iECO111_1330.ECO111_3039,iECO26_1355.ECO26_3279,iECSE_1348.ECSE_2548,iECSP_1301.ECSP_3165,iECUMN_1333.ECUMN_2630,iECs_1301.ECs3175,iEcHS_1320.EcHS_A2440,iEcSMS35_1347.EcSMS35_2446,iEcolC_1368.EcolC_1361,iG2583_1286.G2583_2828,iSFV_1184.SFV_2358,iSF_1195.SF2367,iSFxv_1172.SFxv_2612,iS_1188.S2502,iZ_1308.Z3552	Escherichia	1MVGJ@1224,1RSED@1236,3XPD7@561,COG1896@1,COG1896@2	NA|NA|NA	F	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
b2292	155864.EDL933_3456	0.0	1139.0	Escherichia	yfbS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MU0K@1224,1RMI1@1236,3XNMZ@561,COG0471@1,COG0471@2,COG0490@1,COG0490@2	NA|NA|NA	P	potassium ion transport
b2293	316407.85675348	5.5e-118	430.3	Escherichia	yfbT	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0030145,GO:0042578,GO:0043136,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050084,GO:0050286,GO:0050308,GO:0050897	3.1.3.23	ko:K19270					ko00000,ko01000				Escherichia	1MX3R@1224,1RPX2@1236,3XNSX@561,COG0637@1,COG0637@2	NA|NA|NA	S	Sugar-phosphate phosphohydrolase that appears to contribute to butanol tolerance. Catalyzes the dephosphorylation of D-mannitol 1-phosphate and D-sorbitol 6- phosphate. Is also able to dephosphorylate other sugar phosphates in vitro including ribose-5-phosphate (Rib5P), 2- deoxyribose-5-phosphate, fructose-1-phosphate (Fru1P), fructose-6- phosphate (Fru6P), and glucose-6-phosphate (Glu6P). Selectively hydrolyzes beta-D-glucose-1- phosphate (bGlu1P) and has no activity with the alpha form
b2294	155864.EDL933_3458	4.3e-91	340.5	Escherichia	yfbU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716		ko:K09161					ko00000				Escherichia	1QWV8@1224,1RME1@1236,3XNF4@561,COG3013@1,COG3013@2	NA|NA|NA	S	Belongs to the UPF0304 family
b2295	155864.EDL933_3459	8.9e-83	312.8	Escherichia	yfbV	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010639,GO:0016020,GO:0033043,GO:0033044,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0065007,GO:0071944,GO:2001251		ko:K09899					ko00000				Escherichia	1N172@1224,1S2QC@1236,3XNMA@561,COG3092@1,COG3092@2	NA|NA|NA	S	UPF0208 membrane protein YfbV
b2296	155864.EDL933_3461	5.4e-228	796.6	Escherichia	ackA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006083,GO:0006629,GO:0006631,GO:0006633,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008776,GO:0009058,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019541,GO:0019542,GO:0019752,GO:0032787,GO:0042710,GO:0043167,GO:0043169,GO:0043436,GO:0044010,GO:0044011,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046394,GO:0046459,GO:0046872,GO:0046914,GO:0051703,GO:0051704,GO:0051790,GO:0071704,GO:0072330,GO:0090605,GO:0090609,GO:1901576	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_2492	Escherichia	1MW61@1224,1RMKB@1236,3XNFM@561,COG0282@1,COG0282@2	NA|NA|NA	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
b2297	198214.SF2373	0.0	1365.5	Gammaproteobacteria													Escherichia	1QTS5@1224,1RMJS@1236,COG0280@1,COG0280@2,COG0857@1,COG0857@2	NA|NA|NA	C	belongs to the CobB CobQ family
b2298	316407.1799671	4.5e-280	969.9	Escherichia	yfcC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MY1J@1224,1RS2M@1236,3XQGN@561,COG1288@1,COG1288@2	NA|NA|NA	S	antiporter activity
b2299	155864.EDL933_3464	3.6e-99	367.5	Escherichia	yfcD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1P8AM@1224,1RQA3@1236,3XNZF@561,COG1443@1,COG1443@2	NA|NA|NA	I	Nudix hydrolase
b2300	155864.EDL933_3465	6.1e-102	376.7	Escherichia	yfcE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008081,GO:0008150,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0022607,GO:0030145,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071840		ko:K07095					ko00000				Escherichia	1R3Y7@1224,1RY3X@1236,3XMZI@561,COG0622@1,COG0622@2	NA|NA|NA	S	Shows phosphodiesterase activity, hydrolyzing phosphodiesters bonds in the artificial chromogenic substrates bis-p-nitrophenyl phosphate (bis-pNPP), and less efficiently thymidine 5'-monophosphate p-nitrophenyl ester (pNP-TMP) and p- nitrophenylphosphorylcholine (pNPPC). The physiological substrate is
b2301	316407.1799672	2.6e-120	438.0	Escherichia	yfcF	GO:0000302,GO:0003674,GO:0003824,GO:0004364,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0010035,GO:0016740,GO:0016765,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050896,GO:1901700	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418		R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2		iECW_1372.ECW_m2490,iWFL_1372.ECW_m2490	Escherichia	1NX28@1224,1RQUP@1236,3XNIX@561,COG0625@1,COG0625@2	NA|NA|NA	O	however this activity is as low as 1 of that of GstA. Also displays a GSH-dependent peroxidase activity toward cumene hydroperoxide. Is involved in defense against oxidative stress, probably via its peroxidase activity
b2302	316407.1799673	1.9e-126	458.4	Escherichia	yfcG	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0015036,GO:0016491,GO:0016667,GO:0050896,GO:0055114		ko:K11209					ko00000,ko01000				Escherichia	1MUN3@1224,1RMF7@1236,3XMUA@561,COG0625@1,COG0625@2	NA|NA|NA	O	Belongs to the GST superfamily
b2303	155864.EDL933_3468	2.2e-60	238.0	Escherichia	folX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564	5.1.99.7	ko:K07589	ko00790,map00790		R11082	RC01479	ko00000,ko00001,ko01000				Escherichia	1RDHQ@1224,1S4Q3@1236,3XPQY@561,COG1539@1,COG1539@2	NA|NA|NA	H	Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8- dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis
b2304	316407.1799675	5.3e-172	610.1	Escherichia	yfcH			ko:K07071					ko00000				Escherichia	1MUB4@1224,1RN6A@1236,3XNPS@561,COG1090@1,COG1090@2	NA|NA|NA	S	coenzyme binding
b2305	316407.1799676	1.3e-165	589.0	Escherichia	yfcI	GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360											Escherichia	1MUSP@1224,1RNUW@1236,3XM9B@561,COG5464@1,COG5464@2	NA|NA|NA	S	Upon expression enhances RecA-independent DNA recombination 19-fold, concomitantly reducing viability by 98 and inducing DNA damage as measured by induction of the SOS repair response
b2306	316407.1799677	6.7e-139	500.0	Escherichia	hisP	GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005287,GO:0005290,GO:0005291,GO:0005342,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008144,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015174,GO:0015179,GO:0015238,GO:0015318,GO:0015711,GO:0015802,GO:0015807,GO:0015817,GO:0015849,GO:0015893,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0043090,GO:0043167,GO:0043168,GO:0044464,GO:0045117,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089709,GO:0089718,GO:0097159,GO:0097367,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1901265,GO:1901363,GO:1901474,GO:1902475,GO:1903810,GO:1903825,GO:1905039,GO:1990822	3.6.3.21	ko:K10017	ko02010,map02010	M00225,M00226			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.1		iECIAI39_1322.ECIAI39_2455	Escherichia	1QTS2@1224,1T3WQ@1236,3XRIT@561,COG4598@1,COG4598@2	NA|NA|NA	P	Part of the histidine permease ABC transporter. Also part of a lysine arginine ornithine transporter. Responsible for energy coupling to the transport system (By similarity)
b2307	155864.EDL933_3473	1.1e-127	462.6	Escherichia	hisM	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015849,GO:0016020,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944		ko:K10015	ko02010,map02010	M00225,M00226			ko00000,ko00001,ko00002,ko02000	3.A.1.3.1		iAF1260.b2307,iAPECO1_1312.APECO1_4257,iB21_1397.B21_02192,iBWG_1329.BWG_2081,iE2348C_1286.E2348C_2447,iEC55989_1330.EC55989_2551,iECABU_c1320.ECABU_c26390,iECBD_1354.ECBD_1352,iECB_1328.ECB_02232,iECDH10B_1368.ECDH10B_2469,iECDH1ME8569_1439.ECDH1ME8569_2245,iECD_1391.ECD_02232,iECED1_1282.ECED1_2771,iECH74115_1262.ECH74115_3447,iECIAI1_1343.ECIAI1_2383,iECIAI39_1322.ECIAI39_2456,iECNA114_1301.ECNA114_2397,iECO103_1326.ECO103_2771,iECO111_1330.ECO111_3055,iECO26_1355.ECO26_3295,iECOK1_1307.ECOK1_2540,iECP_1309.ECP_2346,iECS88_1305.ECS88_2454,iECSE_1348.ECSE_2616,iECSF_1327.ECSF_2183,iECSP_1301.ECSP_3182,iECW_1372.ECW_m2496,iECs_1301.ECs3191,iEKO11_1354.EKO11_1458,iETEC_1333.ETEC_2443,iEcDH1_1363.EcDH1_1349,iEcE24377_1341.EcE24377A_2601,iEcSMS35_1347.EcSMS35_2463,iEcolC_1368.EcolC_1345,iG2583_1286.G2583_2844,iJO1366.b2307,iJR904.b2307,iLF82_1304.LF82_1007,iNRG857_1313.NRG857_11685,iSDY_1059.SDY_2506,iSFV_1184.SFV_2374,iSF_1195.SF2383,iSFxv_1172.SFxv_2628,iSSON_1240.SSON_2365,iS_1188.S2518,iSbBS512_1146.SbBS512_E2685,iUMN146_1321.UM146_05275,iUMNK88_1353.UMNK88_2858,iUTI89_1310.UTI89_C2591,iWFL_1372.ECW_m2496,iY75_1357.Y75_RS12100,ic_1306.c2849	Escherichia	1MWI6@1224,1RPT1@1236,3XN40@561,COG4160@1,COG4160@2	NA|NA|NA	E	Part of the histidine permease ABC transporter. Also part of a lysine arginine ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity)
b2308	316407.1799689	2.4e-119	434.9	Escherichia	hisQ	GO:0003333,GO:0003674,GO:0005215,GO:0005287,GO:0005290,GO:0005291,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015174,GO:0015179,GO:0015238,GO:0015318,GO:0015711,GO:0015802,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044464,GO:0045117,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089709,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1901474,GO:1902475,GO:1903810,GO:1903825,GO:1905039,GO:1990822		ko:K10016	ko02010,map02010	M00225,M00226			ko00000,ko00001,ko00002,ko02000	3.A.1.3.1		iSbBS512_1146.SbBS512_E2686	Escherichia	1MY2N@1224,1RNYD@1236,3XPAJ@561,COG4215@1,COG4215@2	NA|NA|NA	P	Part of the histidine permease ABC transporter. Also part of a lysine arginine ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity)
b2309	155864.EDL933_3475	1.9e-141	508.4	Escherichia	hisJ	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464		ko:K10014	ko02010,map02010	M00226			ko00000,ko00001,ko00002,ko02000	3.A.1.3.1		iSDY_1059.SDY_2508	Escherichia	1NT2J@1224,1RRYR@1236,3XNFP@561,COG0834@1,COG0834@2	NA|NA|NA	ET	Part of the histidine permease ABC transporter. Binds histidine. Interacts with HisQMP and stimulates ATPase activity of HisP, which results in histidine translocation (By similarity)
b2310	316407.1799691	2.1e-140	505.0	Escherichia	argT	GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0006950,GO:0006995,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010043,GO:0015711,GO:0015807,GO:0015822,GO:0015849,GO:0015893,GO:0030288,GO:0030313,GO:0031667,GO:0031668,GO:0031669,GO:0031975,GO:0033554,GO:0042221,GO:0042493,GO:0042594,GO:0042597,GO:0043562,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071294,GO:0071496,GO:0071702,GO:0071705,GO:1902022		ko:K10013	ko02010,map02010	M00225			ko00000,ko00001,ko00002,ko02000	3.A.1.3.1		iEC042_1314.EC042_2551	Escherichia	1NT2J@1224,1RRYR@1236,3XNBB@561,COG0834@1,COG0834@2	NA|NA|NA	ET	belongs to the bacterial solute-binding protein 3 family
b2311	155864.EDL933_3477	6.5e-99	366.7	Escherichia	ubiX	GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000			iAF1260.b2311,iAPECO1_1312.APECO1_4253,iB21_1397.B21_02196,iBWG_1329.BWG_2085,iE2348C_1286.E2348C_2451,iEC55989_1330.EC55989_2555,iECBD_1354.ECBD_1348,iECB_1328.ECB_02236,iECDH10B_1368.ECDH10B_2473,iECDH1ME8569_1439.ECDH1ME8569_2249,iECD_1391.ECD_02236,iECED1_1282.ECED1_2775,iECH74115_1262.ECH74115_3451,iECIAI39_1322.ECIAI39_2460,iECNA114_1301.ECNA114_2401,iECO103_1326.ECO103_2775,iECOK1_1307.ECOK1_2544,iECP_1309.ECP_2350,iECS88_1305.ECS88_2458,iECSE_1348.ECSE_2620,iECSF_1327.ECSF_2187,iECSP_1301.ECSP_3186,iECs_1301.ECs3195,iETEC_1333.ETEC_2447,iEcDH1_1363.EcDH1_1345,iEcE24377_1341.EcE24377A_2605,iEcHS_1320.EcHS_A2462,iEcSMS35_1347.EcSMS35_2467,iG2583_1286.G2583_2848,iJO1366.b2311,iJR904.b2311,iLF82_1304.LF82_2354,iNRG857_1313.NRG857_11705,iSDY_1059.SDY_2510,iUMN146_1321.UM146_05255,iUMNK88_1353.UMNK88_2862,iUTI89_1310.UTI89_C2595,iY75_1357.Y75_RS12120,iZ_1308.Z3573	Escherichia	1RA0P@1224,1RPN1@1236,3XMA5@561,COG0163@1,COG0163@2	NA|NA|NA	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
b2312	198214.SF2388	3.3e-291	1006.9	Gammaproteobacteria													Escherichia	1MU0V@1224,1RMYA@1236,COG0034@1,COG0034@2	NA|NA|NA	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
b2313	316407.1799694	1.1e-81	309.3	Escherichia	cvpA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944		ko:K03558					ko00000				Escherichia	1NF4G@1224,1RQ58@1236,3XNHX@561,COG1286@1,COG1286@2	NA|NA|NA	S	colicin V production
b2314	316407.85675354	2.4e-92	345.1	Escherichia	dedD	GO:0000910,GO:0003674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0022402,GO:0030428,GO:0032153,GO:0032506,GO:0042834,GO:0044464,GO:0051301,GO:0097367		ko:K03749					ko00000				Escherichia	1MXHQ@1224,1RRKM@1236,3XMJM@561,COG3147@1,COG3147@2	NA|NA|NA	D	Non-essential cell division protein that could be required for efficient cell constriction
b2315	316407.1799699	1e-240	839.0	Escherichia	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_2514	Escherichia	1MVCH@1224,1RMB0@1236,3XPHJ@561,COG0285@1,COG0285@2	NA|NA|NA	H	Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives
b2316	155864.EDL933_3482	6.9e-167	593.2	Escherichia	accD	GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000			iUTI89_1310.UTI89_C2601	Escherichia	1MW8G@1224,1RNDS@1236,3XMCZ@561,COG0777@1,COG0777@2	NA|NA|NA	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
b2317	155864.EDL933_3483	9.8e-115	419.5	Escherichia	dedA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03975					ko00000				Escherichia	1MX4M@1224,1RPB1@1236,3XMPI@561,COG0586@1,COG0586@2	NA|NA|NA	S	SNARE associated Golgi protein
b2318	316407.1799711	1.3e-156	558.9	Escherichia	truA	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	5.4.99.12	ko:K06173					ko00000,ko01000,ko03016				Escherichia	1MUYI@1224,1RMK2@1236,3XNAY@561,COG0101@1,COG0101@2	NA|NA|NA	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs
b2319	316407.1799712	2.1e-185	654.8	Escherichia	usg	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MUHG@1224,1RNB6@1236,3XM6M@561,COG0136@1,COG0136@2	NA|NA|NA	E	Belongs to the aspartate-semialdehyde dehydrogenase family
b2320	316407.1799713	8.2e-218	762.7	Escherichia	pdxB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0033711,GO:0034641,GO:0036001,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.1.1.290	ko:K03473	ko00750,ko01100,map00750,map01100	M00124	R04210	RC00084	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z3582	Escherichia	1N5TD@1224,1RMFW@1236,3XNMJ@561,COG0111@1,COG0111@2	NA|NA|NA	H	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate
b2321	316407.1799714	2e-175	621.7	Escherichia	flk												Escherichia	1R3XT@1224,1RRUR@1236,2BXIF@1,2Z805@2,3XNYF@561	NA|NA|NA	N	Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar- associated type III secretion
b2322	316407.1799715	2.4e-212	744.6	Escherichia	yfcJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MXYJ@1224,1RPQJ@1236,3XN13@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b2323	199310.c2869	2.5e-228	797.7	Escherichia	fabB	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004			iAF1260.b2323,iAPECO1_1312.APECO1_4241,iB21_1397.B21_02208,iBWG_1329.BWG_2097,iE2348C_1286.E2348C_2463,iEC042_1314.EC042_2564,iEC55989_1330.EC55989_2567,iECABU_c1320.ECABU_c26560,iECBD_1354.ECBD_1336,iECB_1328.ECB_02248,iECDH10B_1368.ECDH10B_2485,iECDH1ME8569_1439.ECDH1ME8569_2261,iECD_1391.ECD_02248,iECED1_1282.ECED1_2787,iECIAI1_1343.ECIAI1_2400,iECIAI39_1322.ECIAI39_2472,iECNA114_1301.ECNA114_2414,iECO103_1326.ECO103_2787,iECO111_1330.ECO111_3071,iECO26_1355.ECO26_3311,iECOK1_1307.ECOK1_2605,iECP_1309.ECP_2362,iECS88_1305.ECS88_2471,iECSE_1348.ECSE_2632,iECSF_1327.ECSF_2200,iECUMN_1333.ECUMN_2663,iECW_1372.ECW_m2512,iEKO11_1354.EKO11_1442,iETEC_1333.ETEC_2459,iEcDH1_1363.EcDH1_1333,iEcHS_1320.EcHS_A2474,iEcSMS35_1347.EcSMS35_2480,iEcolC_1368.EcolC_1329,iJO1366.b2323,iJR904.b2323,iLF82_1304.LF82_0605,iNRG857_1313.NRG857_11765,iSBO_1134.SBO_2360,iUMN146_1321.UM146_05195,iUTI89_1310.UTI89_C2608,iWFL_1372.ECW_m2512,iY75_1357.Y75_RS12180,ic_1306.c2869	Escherichia	1MU1X@1224,1RMDE@1236,3XMTP@561,COG0304@1,COG0304@2	NA|NA|NA	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids
b2324	316407.85675355	0.0	1377.1	Escherichia	mnmC	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0004808,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363	2.1.1.61	ko:K15461			R00601,R08702	RC00003,RC00053,RC00060,RC01483	ko00000,ko01000,ko03016				Escherichia	1MZW5@1224,1RMTE@1236,3XMNY@561,COG0665@1,COG0665@2,COG4121@1,COG4121@2	NA|NA|NA	J	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
b2325	155864.EDL933_3493	4.2e-43	180.3	Escherichia	yfcL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N0DT@1224,1S9BA@1236,2CJ8F@1,32SAV@2,3XPZB@561	NA|NA|NA	S	YfcL protein
b2326	316407.85675357	6.7e-109	399.8	Escherichia	yfcM	GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016705,GO:0016709,GO:0017185,GO:0018126,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0055114,GO:0071704,GO:0072580,GO:1901260,GO:1901564		ko:K09906					ko00000,ko01000,ko03012				Escherichia	1MWTG@1224,1RNHD@1236,3XNI5@561,COG3101@1,COG3101@2	NA|NA|NA	S	Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF- P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine
b2327	155864.EDL933_3495	2.6e-141	508.1	Escherichia	yfcA	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K07090					ko00000				Escherichia	1MXNM@1224,1RRH4@1236,3XN7S@561,COG0730@1,COG0730@2	NA|NA|NA	S	membrane transporter protein
b2328	198214.SF2404	1.8e-158	565.1	Gammaproteobacteria													Escherichia	1MU9I@1224,1RMJK@1236,COG3770@1,COG3770@2	NA|NA|NA	M	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
b2329	316407.85675358	1.4e-206	725.3	Escherichia	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518	Escherichia	1MU98@1224,1RMQS@1236,3XNA3@561,COG0082@1,COG0082@2	NA|NA|NA	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
b2330	316407.85675359	5.9e-182	643.3	Escherichia	prmB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.298	ko:K07320			R10806	RC00003,RC03279	ko00000,ko01000,ko03009				Escherichia	1MX8Q@1224,1RPHQ@1236,3XNMW@561,COG2890@1,COG2890@2	NA|NA|NA	J	Specifically methylates the 50S ribosomal protein L3 on
b2331	198214.SF2406	8e-102	376.3	Gammaproteobacteria													Escherichia	1MVS6@1224,1RPXD@1236,COG2840@1,COG2840@2	NA|NA|NA	S	Belongs to the UPF0115 family
b2332	316407.85675360	5.6e-160	570.1	Gammaproteobacteria													Escherichia	1RDMI@1224,1S4XD@1236,29J73@1,3064I@2	NA|NA|NA	S	Protein of unknown function (DUF2544)
b2333	316407.85675361	3.5e-94	350.9	Escherichia	yfcP	GO:0007155,GO:0008150,GO:0022610											Escherichia	1RIHS@1224,1SBX8@1236,3XQ5G@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
b2334	316407.85675362	5.3e-89	333.6	Escherichia	yfcQ	GO:0007155,GO:0008150,GO:0022610											Escherichia	1REAV@1224,1S7WR@1236,3XQ2E@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
b2335	316407.85675363	4.2e-89	334.0	Escherichia	yfcR	GO:0007155,GO:0008150,GO:0022610											Escherichia	1P2NV@1224,1SRMC@1236,3XRHM@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
b2336	316407.1799727	1.2e-137	495.7	Escherichia	yfcS												Escherichia	1NSX3@1224,1SKBU@1236,3XQKN@561,COG3121@1,COG3121@2	NA|NA|NA	M	Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
b4661	469008.B21_02223	0.0	1769.6	Escherichia	yfcU												Escherichia	1P744@1224,1RN8Z@1236,3XMH0@561,COG3188@1,COG3188@2	NA|NA|NA	NU	outer membrane usher protein
b2339	316407.1799730	1.4e-98	365.5	Escherichia	yfcV	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0007155,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022610,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944											Escherichia	1NDMB@1224,1SCDX@1236,3XPZI@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes
b2340	316407.85675364	5.4e-86	323.6	Escherichia	sixA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564		ko:K08296					ko00000,ko01000				Escherichia	1NAAE@1224,1SD0B@1236,3XMMS@561,COG2062@1,COG2062@2	NA|NA|NA	T	Phosphohistidine phosphatase sixA
b2341	316407.1799732	0.0	1398.6	Escherichia	fadJ	GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,ic_1306.c2886	Escherichia	1MU9P@1224,1RMZ8@1236,3XMJZ@561,COG1024@1,COG1024@2,COG1250@1,COG1250@2	NA|NA|NA	I	Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities
b2342	316407.85675365	5.1e-240	836.6	Escherichia	fadI	GO:0003674,GO:0003824,GO:0003857,GO:0003988,GO:0004300,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033542,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_2806,iEcHS_1320.EcHS_A2493	Escherichia	1MU5G@1224,1RNGU@1236,3XMTM@561,COG0183@1,COG0183@2	NA|NA|NA	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed
b2343	1440052.EAKF1_ch3629	9.3e-46	189.1	Escherichia	yfcZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N0DI@1224,1S91T@1236,3XPUF@561,COG3691@1,COG3691@2	NA|NA|NA	S	Protein of unknown function (DUF406)
b2344	316407.1799743	3.2e-261	907.1	Escherichia	fadL	GO:0003674,GO:0005215,GO:0005319,GO:0005324,GO:0005342,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0009279,GO:0010876,GO:0015075,GO:0015245,GO:0015267,GO:0015288,GO:0015318,GO:0015483,GO:0015711,GO:0015718,GO:0015849,GO:0015908,GO:0015909,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022834,GO:0022836,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0034220,GO:0044462,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K06076					ko00000,ko02000	1.B.9		iECs_1301.ECs3227,iG2583_1286.G2583_2880,iZ_1308.Z3608	Escherichia	1MUU4@1224,1RQZJ@1236,3XNI3@561,COG2067@1,COG2067@2	NA|NA|NA	M	Involved in translocation of long-chain fatty acids across the outer membrane
b2345	481805.EcolC_1308	1.5e-186	658.7	Gammaproteobacteria													Escherichia	1NT0J@1224,1SJK0@1236,2DU94@1,33PFH@2	NA|NA|NA		
b2346	316407.85675367	1.3e-147	528.9	Escherichia	mlaA	GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0015711,GO:0015748,GO:0015914,GO:0016043,GO:0033036,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071840,GO:0120009,GO:0120010		ko:K04754					ko00000				Escherichia	1MVX0@1224,1RNPS@1236,3XPDN@561,COG2853@1,COG2853@2	NA|NA|NA	M	Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
b2347	316407.1799745	1.6e-166	592.0	Escherichia	yfdC	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015318,GO:0015499,GO:0015711,GO:0015718,GO:0015724,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K21990					ko00000	1.A.16.4			Escherichia	1N8YM@1224,1RPJ0@1236,3XN9Y@561,COG2116@1,COG2116@2	NA|NA|NA	P	formate transmembrane transporter activity
b2349	316407.1799746	4.3e-222	776.9	Gammaproteobacteria													Escherichia	1MU23@1224,1RMJ1@1236,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
b2350	316407.1799747	5.5e-59	233.4	Escherichia		GO:0000166,GO:0003674,GO:0003824,GO:0003870,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009987,GO:0016020,GO:0016410,GO:0016491,GO:0016620,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0016903,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576											Escherichia	1N1IP@1224,1S9M8@1236,3XQZB@561,COG2246@1,COG2246@2	NA|NA|NA	U	Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity)
b2351	316407.1799748	7.9e-171	606.3	Escherichia	yfdH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K20534					ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2		Escherichia	1MWE5@1224,1RPCE@1236,3XPTN@561,COG0463@1,COG0463@2	NA|NA|NA	M	Involved in O antigen modification. Catalyzes the transfer of the glucose residue from UDP-glucose to a lipid carrier (By similarity)
b2352	316407.85675368	3.5e-220	770.8	Gammaproteobacteria													Escherichia	1NUQ6@1224,1SN7N@1236,2F17J@1,33U8P@2	NA|NA|NA		
b2354	316407.1799752	3.1e-80	304.3	Escherichia	yfdK	GO:0006950,GO:0006979,GO:0008150,GO:0050896											Escherichia	1N14T@1224,1SB31@1236,2DMUG@1,32TR7@2,3XREF@561	NA|NA|NA	S	response to oxidative stress
b2355	316407.85675369	1.3e-93	349.0	Bacteria													Escherichia	2DKWM@1,30MCA@2	NA|NA|NA		
b2356	316407.85675370	2.1e-50	204.5	Escherichia													Escherichia	1R43Z@1224,1RP5C@1236,3XPZJ@561,COG4725@1,COG4725@2	NA|NA|NA	KT	DNA N-6-adenine-methyltransferase (Dam)
b2357	316407.85675371	9.1e-89	332.8	Escherichia	yfdN												Escherichia	1NHAT@1224,1SH7V@1236,2DTJQ@1,33KP0@2,3XQWW@561	NA|NA|NA	S	PerC transcriptional activator
b2358	199310.c3192	5.9e-69	266.5	Escherichia	yfdO	GO:0006950,GO:0006979,GO:0008150,GO:0050896											Escherichia	1R605@1224,1S0V3@1236,3XPII@561,COG1846@1,COG1846@2	NA|NA|NA	K	Helix-turn-helix domain
b2359	316407.85675373	6.5e-60	236.5	Escherichia	yfdP	GO:0006950,GO:0006979,GO:0008150,GO:0050896											Escherichia	1N8YH@1224,1S4F3@1236,2A7EB@1,30WBS@2,3XPM3@561	NA|NA|NA		
b2360	316407.85675374	2e-149	535.0	Escherichia	yfdQ												Escherichia	1MW4S@1224,1RY8Y@1236,3XQT5@561,COG5532@1,COG5532@2	NA|NA|NA	S	Uncharacterized conserved protein (DUF2303)
b2361	316407.85675375	3.3e-100	370.9	Escherichia	yfdR	GO:0002953,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897		ko:K06952					ko00000				Escherichia	1RACF@1224,1S2SY@1236,3XPMV@561,COG1896@1,COG1896@2	NA|NA|NA	S	5'-deoxynucleotidase activity
b2362	316407.85675376	2.7e-66	257.7	Escherichia	yfdS	GO:0006950,GO:0006979,GO:0008150,GO:0050896											Escherichia	1NCWR@1224,1SD86@1236,2E38W@1,32Y8K@2,3XPSH@561	NA|NA|NA	S	response to oxidative stress
b2363	316407.85675377	6.7e-50	203.0	Escherichia	yfdT												Escherichia	1NVPT@1224,1SPD8@1236,2DVK8@1,33W8P@2,3XR28@561	NA|NA|NA		
b4545	66284.S5FM74_BPSF2	6.8e-18	95.5	Myoviridae													Escherichia	4QHIJ@10239,4QID6@10662,4QRUC@28883,4QY8T@35237	NA|NA|NA	S	Helix-turn-helix domain
b4501	316407.85675379	1.8e-32	144.4	Gammaproteobacteria													Escherichia	1NDQY@1224,1SFTV@1236,COG3311@1,COG3311@2	NA|NA|NA	K	Transcription inhibitory protein for the torCAD operon. Also acts as an excisionase and plays an essential role in the defective prophage CPS53 excision
b2364	316407.1799763	4.3e-180	637.1	Escherichia	dsdC	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K13636					ko00000,ko03000				Escherichia	1MWY0@1224,1RNMN@1236,3XQ94@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional
b2365	316407.1799764	4e-232	810.4	Escherichia	dsdX	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0006950,GO:0006974,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008643,GO:0009987,GO:0015075,GO:0015128,GO:0015144,GO:0015171,GO:0015175,GO:0015238,GO:0015318,GO:0015711,GO:0015718,GO:0015804,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0022889,GO:0031224,GO:0031226,GO:0032329,GO:0033554,GO:0034219,GO:0034220,GO:0035429,GO:0042221,GO:0042493,GO:0042873,GO:0042879,GO:0042940,GO:0042942,GO:0042943,GO:0042945,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1903825,GO:1905039		ko:K13629					ko00000,ko02000	2.A.8.1.5			Escherichia	1MUFG@1224,1RNGE@1236,3XQG5@561,COG2610@1,COG2610@2	NA|NA|NA	P	A D-serine-specific transporter, may function as a H( ) symporter
b2366	316407.1799768	5.2e-256	889.8	Escherichia	dsdA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008721,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009636,GO:0009987,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016840,GO:0016841,GO:0017144,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0033554,GO:0036088,GO:0036094,GO:0042221,GO:0042737,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046416,GO:0048037,GO:0050662,GO:0050896,GO:0051410,GO:0051716,GO:0070178,GO:0070279,GO:0071704,GO:0097159,GO:0098754,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698	4.3.1.18	ko:K01753	ko00260,map00260		R00221	RC02600	ko00000,ko00001,ko01000			iECED1_1282.ECED1_2813,iLF82_1304.LF82_0525,iNRG857_1313.NRG857_11890	Escherichia	1MUJS@1224,1RNBW@1236,3XNRT@561,COG3048@1,COG3048@2	NA|NA|NA	E	D-serine dehydratase
b2367	316407.1799769	1.9e-281	974.5	Escherichia	emrY	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944		ko:K07786	ko02020,map02020				ko00000,ko00001,ko02000	2.A.1.3.36			Escherichia	1RGPN@1224,1T1M7@1236,3XRN3@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	multidrug resistance
b2368	316407.85675380	9.9e-211	739.2	Escherichia	emrK	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0042221,GO:0046677,GO:0050896,GO:0051716		ko:K07797	ko02020,map02020				ko00000,ko00001	8.A.1			Escherichia	1MU7I@1224,1RMAD@1236,3XP2J@561,COG1566@1,COG1566@2	NA|NA|NA	V	Multidrug resistance protein
b2369	155864.EDL933_3537	7.5e-109	399.8	Gammaproteobacteria													Escherichia	1R5PI@1224,1RP5B@1236,COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
b2370	316407.1799781	0.0	2382.4	Escherichia	evgS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009268,GO:0009628,GO:0009927,GO:0009987,GO:0010447,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0140096,GO:1901564	2.7.13.3	ko:K07679	ko02020,ko05133,map02020,map05133	M00477			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1NRP8@1224,1RQCU@1236,3XMTU@561,COG0642@1,COG0784@1,COG0784@2,COG0834@1,COG0834@2,COG2198@1,COG2198@2,COG2205@2	NA|NA|NA	T	PhoQ Sensor
b2371	316407.1799782	1e-223	782.3	Escherichia	yfdE	GO:0003674,GO:0003824,GO:0008410,GO:0016740,GO:0016782,GO:0036412	2.8.3.19	ko:K18702					ko00000,ko01000				Escherichia	1MU2K@1224,1RNB5@1236,3XQJV@561,COG1804@1,COG1804@2	NA|NA|NA	C	Involved in the catabolism of oxalate and in the adapatation to low pH. ACOCT serves to prime the oxalate-induced acid tolerance response (ATR) cycle by producing substrate for oxalyl-CoA decarboxylase (OXC) and formyl-coenzyme A transferase (FCOCT). Catalyzes the reversible conversion of acetyl-CoA and oxalate to oxalyl-CoA and acetate. It can also use formyl-CoA and oxalate to produce oxalyl-CoA and formate with significantly reduced specific activity
b2372	155864.EDL933_3541	1.3e-165	589.0	Escherichia	yfdV	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07088					ko00000			iECW_1372.ECW_m2605,iWFL_1372.ECW_m2605	Escherichia	1R71W@1224,1T9HF@1236,3XQ6G@561,COG0679@1,COG0679@2	NA|NA|NA	U	transmembrane transport
b2373	155864.EDL933_3542	0.0	1110.1	Escherichia	oxc	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0008150,GO:0008152,GO:0008949,GO:0009056,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019752,GO:0019842,GO:0030554,GO:0030976,GO:0032553,GO:0032555,GO:0032559,GO:0033609,GO:0033611,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043531,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0097159,GO:0097367,GO:0104004,GO:1901265,GO:1901363,GO:1901575,GO:1901681	4.1.1.8	ko:K01577	ko00630,ko01100,map00630,map01100		R01908	RC00620	ko00000,ko00001,ko01000			iEcSMS35_1347.EcSMS35_2523	Escherichia	1MXDW@1224,1RR5B@1236,3XRIZ@561,COG0028@1,COG0028@2	NA|NA|NA	EH	Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the decarboxylation of oxalyl-CoA to yield carbon dioxide and formyl-CoA
b2374	198214.SF2441	7.1e-247	859.4	Gammaproteobacteria													Escherichia	1MU2K@1224,1RNB5@1236,COG1804@1,COG1804@2	NA|NA|NA	C	acyl-CoA transferases carnitine dehydratase
b2375	316407.85675383	1.2e-98	365.9	Gammaproteobacteria													Escherichia	1RGE3@1224,1S5F4@1236,28JAR@1,2Z95M@2	NA|NA|NA	S	YfdX protein
b2377	316407.85675385	5.7e-36	156.4	Escherichia	yfdY												Escherichia	1NFE4@1224,1SEI2@1236,2C7SD@1,330JG@2,3XR5T@561	NA|NA|NA	S	Protein of unknown function (DUF2545)
b2378	155864.EDL933_3546	9.3e-180	636.0	Escherichia	lpxP	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008951,GO:0009058,GO:0009247,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0046467,GO:0050896,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.242	ko:K12974			R10906	RC00037,RC00039	ko00000,ko01000,ko01005			iEC042_1314.EC042_2597	Escherichia	1MVNI@1224,1RMZ5@1236,3XMPR@561,COG1560@1,COG1560@2	NA|NA|NA	M	Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(palmitoleoyl)-lipid IV(A)
b2379	316407.1799790	2.3e-242	844.3	Escherichia	alaC	GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607		ko:K14261					ko00000,ko01000,ko01007			iEcSMS35_1347.EcSMS35_2531,iSBO_1134.SBO_2405	Escherichia	1MWS8@1224,1RQBM@1236,3XMF2@561,COG0436@1,COG0436@2	NA|NA|NA	E	Aminotransferase
b2380	316407.85675386	0.0	1098.2	Escherichia	ypdA	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K02478					ko00000,ko01000,ko01001,ko02022				Escherichia	1QUB1@1224,1T1RX@1236,3XNEW@561,COG3275@1,COG3275@2	NA|NA|NA	T	Member of the two-component regulatory system YpdA YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA YpdB, the high-affinity pyruvate signaling system BtsS BtsR and their respective target proteins, YhjX and YjiY. YpdA activates YpdB by phosphorylation in response to high concentrations of extracellular pyruvate. Activation of the YpdA YpdB signaling cascade also promotes BtsS BtsR-mediated yjiY expression
b2381	155864.EDL933_3550	8.6e-136	489.6	Escherichia	ypdB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K02477					ko00000,ko02022				Escherichia	1MVJI@1224,1RQ5T@1236,3XMRB@561,COG3279@1,COG3279@2	NA|NA|NA	K	Member of the two-component regulatory system YpdA YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA YpdB, the high-affinity pyruvate signaling system BtsS BtsR and their respective target proteins, YhjX and YjiY. YpdB regulates expression of yhjX by binding to its promoter region. Activation of the YpdA YpdB signaling cascade also promotes BtsS BtsR-mediated yjiY expression
b2382	316407.1799793	4.6e-165	587.0	Escherichia	ypdC	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141											Escherichia	1R55C@1224,1S0MA@1236,3XNAV@561,COG2207@1,COG2207@2	NA|NA|NA	K	Transcriptional regulator
b2383	316407.1799794	0.0	1625.5	Escherichia	fryA		2.7.3.9	ko:K08483,ko:K11189,ko:K11201	ko02060,map02060	M00306			ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7			Escherichia	1MUT8@1224,1RN6R@1236,3XP8W@561,COG1080@1,COG1080@2,COG1762@1,COG1762@2,COG1925@1,COG1925@2	NA|NA|NA	G	Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport
b2384	316407.1799795	1.4e-192	678.7	Escherichia	ypdE	GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564											Escherichia	1MXEU@1224,1RYRZ@1236,3XN5P@561,COG1363@1,COG1363@2	NA|NA|NA	G	Has a broad aminopeptidase activity on non-blocked peptides by progressively cleaving amino acids off the peptide substrate. Aminopeptidase activity stops at the residue before the first proline in the peptide. Cannot cleave when proline is the first N-terminal residue
b2385	316407.85675387	8.1e-199	699.5	Escherichia	ypdF	GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564		ko:K08326					ko00000,ko01000,ko01002				Escherichia	1MUZS@1224,1RYKI@1236,3XNJ0@561,COG0006@1,COG0006@2	NA|NA|NA	E	Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro Ala Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is alanine, asparagine or methionine
b2386	316407.1799797	4.4e-225	786.9	Escherichia	fryC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563		ko:K11203		M00306			ko00000,ko00002,ko02000	4.A.2.1			Escherichia	1R4ND@1224,1RZX0@1236,3XPEA@561,COG1299@1,COG1299@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
b2387	155864.EDL933_3556	4.2e-50	203.8	Escherichia	fryB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582		ko:K11202		M00306			ko00000,ko00002,ko01000,ko02000	4.A.2.1			Escherichia	1REBG@1224,1S587@1236,3XPNP@561,COG1445@1,COG1445@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport
b2388	155864.EDL933_3557	5.9e-185	653.3	Escherichia	glk	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iNRG857_1313.NRG857_12000	Escherichia	1MVFI@1224,1RNUY@1236,3XP7Q@561,COG0837@1,COG0837@2	NA|NA|NA	F	Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate
b2389	155864.EDL933_3558	1.3e-224	785.4	Escherichia	yfeO	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MUBJ@1224,1RR1R@1236,3XM3B@561,COG0038@1,COG0038@2	NA|NA|NA	P	ion-transport protein YfeO
b2390	155864.EDL933_3559	9.7e-23	112.8	Escherichia	ypeC												Escherichia	1RHG1@1224,1S60N@1236,2B58A@1,31Y28@2,3XPSE@561	NA|NA|NA	S	Protein of unknown function (DUF2502)
b2392	199310.c2931	9.5e-220	769.2	Escherichia	mntH	GO:0000041,GO:0003674,GO:0005215,GO:0005384,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0006826,GO:0006828,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015086,GO:0015291,GO:0015292,GO:0015293,GO:0015318,GO:0015672,GO:0015684,GO:0015691,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0044425,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070574,GO:0070838,GO:0071421,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K03322					ko00000,ko02000	2.A.55.2.6,2.A.55.3		iSF_1195.SF2457	Escherichia	1MW6X@1224,1RNA2@1236,3XMY0@561,COG1914@1,COG1914@2	NA|NA|NA	P	H( )-stimulated, divalent metal cation uptake system
b2393	199310.c2932	2.2e-205	721.5	Escherichia	nupC	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015212,GO:0015213,GO:0015214,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015506,GO:0015672,GO:0015858,GO:0015861,GO:0015862,GO:0015864,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072531,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1901505,GO:1901642,GO:1902600		ko:K11535					ko00000,ko02000	2.A.41.1		iECOK1_1307.ECOK1_2708	Escherichia	1MXXX@1224,1RMBX@1236,3XM5K@561,COG1972@1,COG1972@2	NA|NA|NA	U	Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force
b2394	203275.BFO_0831	1.2e-210	738.8	Bacteria													Escherichia	COG3385@1,COG3385@2	NA|NA|NA	L	transposase activity
b2395	316407.85675392	0.0	1444.9	Escherichia	yfeA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008081,GO:0016020,GO:0016787,GO:0016788,GO:0042578,GO:0044464,GO:0071111,GO:0071944											Escherichia	1RGCV@1224,1T1U0@1236,3XNQ0@561,COG2199@1,COG2199@2,COG2200@1,COG2200@2	NA|NA|NA	T	cyclic-guanylate-specific phosphodiesterase activity
b2398	155864.EDL933_3563	9.8e-58	229.2	Escherichia	yfeC												Escherichia	1RGU5@1224,1S6VV@1236,3XPQD@561,COG3415@1,COG3415@2	NA|NA|NA	L	Putative transcription regulator (DUF1323)
b2399	316407.1799813	2.4e-68	264.6	Escherichia	yfeD												Escherichia	1MYR7@1224,1S85P@1236,3XPIZ@561,COG3415@1,COG3415@2	NA|NA|NA	L	sequence-specific DNA binding
b2400	316407.1799814	1e-281	975.3	Escherichia	gltX	GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016			iEC042_1314.EC042_2616	Escherichia	1MUCR@1224,1RN3R@1236,3XMCH@561,COG0008@1,COG0008@2	NA|NA|NA	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
b2405	316407.1799815	4.5e-163	580.5	Escherichia	xapR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141											Escherichia	1MV0Z@1224,1SYPN@1236,3XN83@561,COG0583@1,COG0583@2	NA|NA|NA	K	Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine
b2406	316407.1799816	6.5e-232	809.7	Escherichia	xapB	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009987,GO:0015211,GO:0015553,GO:0015858,GO:0015860,GO:0015863,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072530,GO:1901264,GO:1901360,GO:1901505,GO:1901642		ko:K11537					ko00000,ko02000	2.A.1.10.2		iECS88_1305.ECS88_2595	Escherichia	1MWI9@1224,1RMU5@1236,3XP72@561,COG2211@1,COG2211@2	NA|NA|NA	G	Uptake of xanthosine. Driven by a proton motive force. Can also transport other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine
b2407	316407.1799817	5e-156	557.0	Escherichia	xapA	GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006148,GO:0006149,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008617,GO:0009056,GO:0009116,GO:0009119,GO:0009120,GO:0009164,GO:0009987,GO:0015949,GO:0016043,GO:0016740,GO:0016757,GO:0016763,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0022607,GO:0034214,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0042454,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046094,GO:0046102,GO:0046115,GO:0046121,GO:0046122,GO:0046124,GO:0046128,GO:0046130,GO:0046483,GO:0046700,GO:0047724,GO:0047975,GO:0051259,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072521,GO:0072523,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658,GO:1903227,GO:1903228		ko:K03815	ko00230,ko01100,ko01110,map00230,map01100,map01110		R02297	RC00122	ko00000,ko00001,ko01000			iUMN146_1321.UM146_04590,iUTI89_1310.UTI89_C2739	Escherichia	1MUWW@1224,1RS0S@1236,3XPEV@561,COG0005@1,COG0005@2	NA|NA|NA	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
b2408	316407.1799822	3.1e-152	544.3	Escherichia	yfeN												Escherichia	1R4VQ@1224,1RRVS@1236,28ICJ@1,2Z8EW@2,3XQ4Z@561	NA|NA|NA	S	Nucleoside-specific channel-forming protein, Tsx
b2409	198214.SF2464	4.4e-169	600.5	Gammaproteobacteria													Escherichia	1MUWX@1224,1RNZB@1236,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
b2410	316407.85675394	1.3e-179	635.6	Escherichia	yfeH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K14347					ko00000,ko02000,ko04147	2.A.93.1			Escherichia	1MUMM@1224,1RN2S@1236,3XM62@561,COG0385@1,COG0385@2	NA|NA|NA	S	symporter activity
b4546	155864.EDL933_3573	4e-33	146.7	Escherichia	ypeB			ko:K09954					ko00000				Escherichia	1N7GT@1224,1SCBX@1236,3XQ26@561,COG3530@1,COG3530@2	NA|NA|NA	S	Putative quorum-sensing-regulated virulence factor
b2411	316407.85675396	0.0	1317.4	Escherichia	ligA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430		R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400			iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,ic_1306.c2945	Escherichia	1MV3R@1224,1RPAV@1236,3XMQY@561,COG0272@1,COG0272@2	NA|NA|NA	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
b2412	316407.1799827	2.2e-126	458.8	Escherichia	zipA	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047		ko:K03528					ko00000,ko03036				Escherichia	1MVHR@1224,1RMDB@1236,3XMQT@561,COG3115@1,COG3115@2	NA|NA|NA	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of
b2413	155864.EDL933_3576	5.6e-146	523.5	Escherichia	cysZ	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600		ko:K06203					ko00000			iJR904.b2413	Escherichia	1MVFT@1224,1RMQT@1236,3XP0T@561,COG2981@1,COG2981@2	NA|NA|NA	E	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
b2414	155864.EDL933_3577	1.7e-176	625.2	Escherichia	cysK	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009333,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000			iAF1260.b2414,iAPECO1_1312.APECO1_4131,iB21_1397.B21_02275,iBWG_1329.BWG_2176,iE2348C_1286.E2348C_2600,iEC042_1314.EC042_2623,iEC55989_1330.EC55989_2704,iECABU_c1320.ECABU_c27350,iECBD_1354.ECBD_1267,iECB_1328.ECB_02314,iECDH10B_1368.ECDH10B_2579,iECDH1ME8569_1439.ECDH1ME8569_2348,iECD_1391.ECD_02314,iECED1_1282.ECED1_2858,iECH74115_1262.ECH74115_3645,iECIAI1_1343.ECIAI1_2472,iECNA114_1301.ECNA114_2491,iECO103_1326.ECO103_2933,iECO111_1330.ECO111_3144,iECO26_1355.ECO26_3467,iECOK1_1307.ECOK1_2731,iECP_1309.ECP_2438,iECS88_1305.ECS88_2604,iECSE_1348.ECSE_2705,iECSF_1327.ECSF_2278,iECSP_1301.ECSP_3362,iECUMN_1333.ECUMN_2736,iECW_1372.ECW_m2643,iECs_1301.ECs3286,iEKO11_1354.EKO11_1314,iETEC_1333.ETEC_2527,iEcDH1_1363.EcDH1_1247,iEcHS_1320.EcHS_A2549,iEcSMS35_1347.EcSMS35_2569,iEcolC_1368.EcolC_1264,iG2583_1286.G2583_2946,iJO1366.b2414,iJR904.b2414,iLF82_1304.LF82_0418,iNRG857_1313.NRG857_12105,iSSON_1240.SSON_2503,iSbBS512_1146.SbBS512_E2766,iUMN146_1321.UM146_04550,iUMNK88_1353.UMNK88_3016,iUTI89_1310.UTI89_C2747,iWFL_1372.ECW_m2643,iY75_1357.Y75_RS12650,iZ_1308.Z3680	Escherichia	1MUBE@1224,1RN6J@1236,3XNFV@561,COG0031@1,COG0031@2	NA|NA|NA	E	stimulation does not require O-acetylserine sulfhydrylase activity. CdiA is the toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion (experiments done in strains BW25113 and X90, both K12 derivatives). This protein is not required for CDI of strain EC93, whose toxin may function by forming inner cell membrane pores
b2415	1028307.EAE_00365	1.9e-37	161.4	Enterobacter													Escherichia	1N0CV@1224,1S9R2@1236,3X2IH@547,COG1925@1,COG1925@2	NA|NA|NA	G	PTS HPr component phosphorylation site
b2416	316407.1799835	0.0	1090.1	Escherichia	ptsI	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0008150,GO:0008643,GO:0008965,GO:0009401,GO:0016740,GO:0016772,GO:0016775,GO:0019197,GO:0032991,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051179,GO:0051234,GO:0071702	2.7.3.9	ko:K08483	ko02060,map02060				ko00000,ko00001,ko01000,ko02000	8.A.7		iB21_1397.B21_02277,iE2348C_1286.E2348C_2602,iEC042_1314.EC042_2625,iECBD_1354.ECBD_1265,iECB_1328.ECB_02316,iECD_1391.ECD_02316,iECH74115_1262.ECH74115_3647,iECIAI1_1343.ECIAI1_2474,iECIAI39_1322.ECIAI39_2562,iECO103_1326.ECO103_2935,iECO111_1330.ECO111_3146,iECO26_1355.ECO26_3469,iECP_1309.ECP_2440,iECSE_1348.ECSE_2707,iECSP_1301.ECSP_3364,iECUMN_1333.ECUMN_2738,iECW_1372.ECW_m2645,iECs_1301.ECs3288,iEKO11_1354.EKO11_1312,iEcE24377_1341.EcE24377A_2703,iEcHS_1320.EcHS_A2551,iEcSMS35_1347.EcSMS35_2571,iEcolC_1368.EcolC_1262,iLF82_1304.LF82_1770,iNRG857_1313.NRG857_12115,iSBO_1134.SBO_2440,iSDY_1059.SDY_2613,iSFV_1184.SFV_2468,iSF_1195.SF2471,iSFxv_1172.SFxv_2720,iSSON_1240.SSON_2505,iS_1188.S2617,iUMNK88_1353.UMNK88_3018,iWFL_1372.ECW_m2645,iZ_1308.Z3682	Escherichia	1MUT8@1224,1RN6R@1236,3XMY3@561,COG1080@1,COG1080@2	NA|NA|NA	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
b2417	198214.SF2472	2.5e-86	324.7	Gammaproteobacteria													Escherichia	1MWIQ@1224,1RNE3@1236,COG2190@1,COG2190@2	NA|NA|NA	G	pts system
b2418	316407.1799837	1.3e-154	552.4	Escherichia	pdxK	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008478,GO:0008614,GO:0008615,GO:0008902,GO:0009058,GO:0009108,GO:0009110,GO:0009443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019842,GO:0030170,GO:0030955,GO:0031420,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0046872,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.7.1.35	ko:K00868	ko00750,ko01100,map00750,map01100		R00174,R01909,R02493	RC00002,RC00017	ko00000,ko00001,ko01000			iSDY_1059.SDY_2615	Escherichia	1MVC9@1224,1RMIE@1236,3XNTK@561,COG2240@1,COG2240@2	NA|NA|NA	H	B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP
b2419	316407.1799838	1.4e-62	245.4	Escherichia	yfeK												Escherichia	1NBRM@1224,1S5P3@1236,2CKE6@1,32ZEV@2,3XPSY@561	NA|NA|NA	S	Family of unknown function (DUF5329)
b2420	316407.1799839	1.6e-142	511.9	Escherichia	yfeS												Escherichia	1NGGN@1224,1TGCK@1236,3XQJ6@561,COG3831@1,COG3831@2,COG4884@1,COG4884@2	NA|NA|NA	S	WGR domain
b2421	316407.1799840	1.9e-169	601.7	Escherichia	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_2444	Escherichia	1MUBE@1224,1RN6J@1236,3XM4U@561,COG0031@1,COG0031@2	NA|NA|NA	E	Belongs to the cysteine synthase cystathionine beta- synthase family
b2422	316407.1799841	1.1e-208	732.3	Escherichia	cysA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3		iE2348C_1286.E2348C_2607,iSSON_1240.SSON_2511	Escherichia	1QTTT@1224,1RN1B@1236,3XMNN@561,COG1118@1,COG1118@2	NA|NA|NA	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
b2423	199310.c2957	5.6e-158	563.5	Escherichia	cysW	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02047	ko00920,ko02010,map00920,map02010	M00185			ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3			Escherichia	1MV8X@1224,1RNZK@1236,3XN3S@561,COG4208@1,COG4208@2	NA|NA|NA	P	Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate thiosulfate import. Probably responsible for the translocation of the substrate across the membrane
b2424	316407.1799843	6.1e-146	523.5	Escherichia	cysU	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008272,GO:0015698,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072348		ko:K02046	ko00920,ko02010,map00920,map02010	M00185			ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3		iSDY_1059.SDY_2620	Escherichia	1QTTU@1224,1RS0W@1236,3XM2P@561,COG0555@1,COG0555@2	NA|NA|NA	P	Sulfate transport system permease protein CysT
b2425	316407.1799844	5.1e-195	686.8	Escherichia	cysP	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006790,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008152,GO:0008272,GO:0009987,GO:0015698,GO:0015709,GO:0030288,GO:0030313,GO:0031975,GO:0036173,GO:0042597,GO:0043167,GO:0043168,GO:0043199,GO:0044237,GO:0044464,GO:0051179,GO:0051234,GO:0072348,GO:1901681		ko:K02048	ko00920,ko02010,map00920,map02010	M00185			ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3		iECIAI39_1322.ECIAI39_2570	Escherichia	1QTZY@1224,1T1JH@1236,3XM7N@561,COG4150@1,COG4150@2	NA|NA|NA	P	Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport
b2426	316407.85675399	6.6e-142	510.0	Escherichia	ucpA												Escherichia	1MURZ@1224,1RMUM@1236,3XMSX@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	oxidoreductase activity
b2427	316407.1799856	3.7e-146	524.2	Escherichia	murR	GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K15835					ko00000,ko03000				Escherichia	1ND5W@1224,1RNCI@1236,3XNB2@561,COG1737@1,COG1737@2	NA|NA|NA	K	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator
b2428	316407.85675400	8e-160	569.7	Escherichia	murQ	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006040,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009254,GO:0016787,GO:0016801,GO:0016803,GO:0016829,GO:0016835,GO:0030203,GO:0043170,GO:0046348,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901575	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100		R08555	RC00397,RC00746	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_3658,iECSP_1301.ECSP_3375,iECs_1301.ECs3299,iG2583_1286.G2583_2959	Escherichia	1MVDR@1224,1RN3P@1236,3XNV3@561,COG2103@1,COG2103@2	NA|NA|NA	S	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
b2429	316407.1799859	4.5e-266	923.3	Escherichia	murP	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090588	2.7.1.192	ko:K11191,ko:K11192	ko00520,ko02060,map00520,map02060	M00303	R08559	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.2.7		iECIAI39_1322.ECIAI39_2574,iECNA114_1301.ECNA114_2504,iECSF_1327.ECSF_2291	Escherichia	1N3C1@1224,1RQMX@1236,3XNT5@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is
b2430	316407.85675401	5.1e-256	889.8	Gammaproteobacteria													Escherichia	1QVWF@1224,1T2KR@1236,COG1680@1,COG1680@2	NA|NA|NA	V	COG1680 Beta-lactamase class C and other penicillin binding proteins
b2431	316407.85675402	6.3e-173	613.2	Escherichia	yfeX	GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020037,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1990748		ko:K07223					ko00000				Escherichia	1MWDD@1224,1RMZJ@1236,3XM48@561,COG2837@1,COG2837@2	NA|NA|NA	P	peroxidase activity
b2432	316407.85675403	3.3e-106	391.0	Escherichia	yfeY												Escherichia	1RB4E@1224,1RRU9@1236,28PEC@1,2ZC5Z@2,3XMY9@561	NA|NA|NA	S	Protein of unknown function (DUF1131)
b2433	316407.85675404	1.3e-81	308.9	Escherichia	yfeZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RD7G@1224,1S4HS@1236,2C10D@1,32RZ4@2,3XPS1@561	NA|NA|NA	S	Protein of unknown function (DUF2919)
b2434	316407.85675405	1.4e-77	295.4	Escherichia	ypeA												Escherichia	1RA6D@1224,1S2F2@1236,3XPJV@561,COG0454@1,COG0456@2	NA|NA|NA	K	transferase activity, transferring acyl groups other than amino-acyl groups
b2435	316407.1799865	2e-155	555.1	Escherichia	amiA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008270,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036				Escherichia	1MUQK@1224,1RMQR@1236,3XMRY@561,COG0860@1,COG0860@2	NA|NA|NA	M	N-acetylmuramoyl-L-alanine amidase amiA
b2436	316407.1799866	4.4e-182	643.7	Escherichia	hemF	GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000			iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760	Escherichia	1MWMF@1224,1RMM8@1236,3XMMV@561,COG0408@1,COG0408@2	NA|NA|NA	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX
b2437	316407.1799867	5.1e-206	723.4	Escherichia	eutR	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009438,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019172,GO:0019243,GO:0019249,GO:0019438,GO:0019752,GO:0032774,GO:0032787,GO:0034641,GO:0034645,GO:0034654,GO:0042180,GO:0042182,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0046483,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901575,GO:1901576,GO:1901615,GO:1901617		ko:K04033					ko00000,ko03000				Escherichia	1Q3UX@1224,1RS88@1236,3XMYS@561,COG2207@1,COG2207@2	NA|NA|NA	K	Activates the transcription of the eut operon. Also positively regulates its own transcription. Probably binds ethanolamine and vitamin B12 as effectors (By similarity)
b2438	316407.1799868	2.8e-85	321.2	Escherichia	eutK	GO:0003674,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0031469,GO:0031471,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0050896		ko:K04025					ko00000				Escherichia	1RCBV@1224,1S2HK@1236,3XP2V@561,COG4577@1,COG4577@2	NA|NA|NA	CQ	Ethanolamine utilization protein EutK
b2439	316407.85675406	3.1e-116	424.5	Gammaproteobacteria													Escherichia	1QGJB@1224,1RSFT@1236,COG4816@1,COG4816@2	NA|NA|NA	E	Carboxysome structural protein involved in ethanolamine utilization
b2440	316407.1799869	1.9e-161	575.1	Escherichia	eutC	GO:0005575,GO:0005622,GO:0005623,GO:0009350,GO:0032991,GO:0044424,GO:0044464,GO:1902494	4.3.1.7	ko:K03736	ko00564,ko01100,map00564,map01100		R00749	RC00370	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_2515,iECSF_1327.ECSF_2301	Escherichia	1MWQI@1224,1RQ2T@1236,3XNZD@561,COG4302@1,COG4302@2	NA|NA|NA	E	Belongs to the EutC family
b2441	155864.EDL933_3604	3.6e-260	903.7	Escherichia	eutB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009350,GO:0032991,GO:0044424,GO:0044444,GO:0044464,GO:1902494	4.3.1.7	ko:K03735	ko00564,ko01100,map00564,map01100		R00749	RC00370	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_4107,iECOK1_1307.ECOK1_2756,iECS88_1305.ECS88_2629,iUMN146_1321.UM146_04425,iUTI89_1310.UTI89_C2774	Escherichia	1MUR4@1224,1RPN8@1236,3XN42@561,COG4303@1,COG4303@2	NA|NA|NA	E	ethanolamine ammonia-lyase activity
b2442	511145.b2442	4.2e-228	797.0	Escherichia	intB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MU23@1224,1RMJ1@1236,3XN9B@561,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
b2451	316407.85675407	3.5e-263	913.7	Escherichia	eutA	GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0030091,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009,GO:0071704,GO:1901564		ko:K04019	ko00564,ko01100,map00564,map01100		R00749	RC00370	ko00000,ko00001				Escherichia	1PPGT@1224,1RYIP@1236,3XNX1@561,COG4819@1,COG4819@2	NA|NA|NA	E	ethanolamine utilization protein
b2452	316407.85675408	1.2e-217	762.3	Gammaproteobacteria													Escherichia	1NPK6@1224,1S0MH@1236,COG3192@1,COG3192@2	NA|NA|NA	E	ethanolamine utilization protein
b2453	316407.1799879	1.9e-217	761.5	Escherichia	eutG	GO:0003674,GO:0003824,GO:0004022,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0044424,GO:0044444,GO:0044464,GO:0055114		ko:K04022	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130		R00754	RC00088	ko00000,ko00001				Escherichia	1MVPH@1224,1RMVU@1236,3XPC0@561,COG1454@1,COG1454@2	NA|NA|NA	C	Ethanolamine utilization protein eutG
b2454	316407.1799880	7.5e-160	569.7	Escherichia	eutJ			ko:K04024					ko00000				Escherichia	1MVXX@1224,1S06N@1236,3XNST@561,COG4820@1,COG4820@2	NA|NA|NA	E	Ethanolamine utilization
b2455	316407.1799881	5.7e-253	879.8	Escherichia	eutE	GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114		ko:K04021	ko00620,ko01100,ko01120,map00620,map01100,map01120		R00228	RC00004,RC01195	ko00000,ko00001				Escherichia	1QUBI@1224,1RP7H@1236,3XMH5@561,COG1012@1,COG1012@2	NA|NA|NA	C	Ethanolamine utilization protein EutE
b2456	199310.c2981	1e-47	195.7	Escherichia	eutN	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716		ko:K04028					ko00000				Escherichia	1RIK4@1224,1S6GW@1236,3XR0M@561,COG4576@1,COG4576@2	NA|NA|NA	CQ	May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place
b2457	155864.EDL933_3611	3.1e-44	184.1	Escherichia	eutM	GO:0003674,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0031469,GO:0031471,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464		ko:K04027					ko00000				Escherichia	1RH1U@1224,1S6YK@1236,3XR19@561,COG4577@1,COG4577@2	NA|NA|NA	CQ	May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place
b2458	316407.1799884	9.6e-186	656.0	Escherichia	eutD	GO:0003674,GO:0003824,GO:0006950,GO:0008150,GO:0008959,GO:0009266,GO:0009408,GO:0009628,GO:0016407,GO:0016740,GO:0016746,GO:0016747,GO:0050896		ko:K04020	ko00620,ko01100,map00620,map01100		R00230	RC00004,RC02746	ko00000,ko00001			iE2348C_1286.E2348C_2692	Escherichia	1QTS5@1224,1RMJS@1236,3XNTZ@561,COG0280@1,COG0280@2	NA|NA|NA	C	phosphate acetyltransferase activity
b2459	199310.c2984	2.8e-148	531.2	Escherichia	eutT		2.5.1.17	ko:K04032	ko00860,ko01100,map00860,map01100		R01492	RC00533	ko00000,ko00001,ko01000				Escherichia	1R4BY@1224,1RMDG@1236,3XNP6@561,COG4812@1,COG4812@2	NA|NA|NA	F	Ethanolamine utilization cobalamin adenosyltransferase
b2460	316407.85675411	1.6e-126	458.8	Escherichia	eutQ			ko:K04030					ko00000				Escherichia	1R6MF@1224,1RRZH@1236,3XMB2@561,COG4766@1,COG4766@2	NA|NA|NA	E	ethanolamine metabolic process
b2461	316407.85675412	9.1e-86	322.8	Escherichia	eutP			ko:K04029					ko00000				Escherichia	1R8GN@1224,1RRWJ@1236,3XN68@561,COG4917@1,COG4917@2	NA|NA|NA	E	ethanolamine metabolic process
b2462	155864.EDL933_3616	2.2e-54	218.0	Escherichia	eutS	GO:0003674,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0031469,GO:0031471,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464		ko:K04031					ko00000				Escherichia	1RFDA@1224,1S595@1236,3XPRX@561,COG4810@1,COG4810@2	NA|NA|NA	E	May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place
b2463	316407.85675414	0.0	1476.8	Escherichia	maeB	GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000				Escherichia	1MU0A@1224,1RN5F@1236,3XNEY@561,COG0280@1,COG0280@2,COG0281@1,COG0281@2	NA|NA|NA	C	malate dehydrogenase (decarboxylating) (NADP+) activity
b2464	155864.EDL933_3618	3.1e-178	630.9	Escherichia	talA	GO:0003674,GO:0003824,GO:0004801,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016744,GO:0044424,GO:0044444,GO:0044464	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000				Escherichia	1MWQ8@1224,1RMS0@1236,3XMID@561,COG0176@1,COG0176@2	NA|NA|NA	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
b2465	316407.1799889	0.0	1364.4	Escherichia	tktB	GO:0003674,GO:0003824,GO:0004802,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016744,GO:0044424,GO:0044444,GO:0044464	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,ic_1306.c2990	Escherichia	1MUEY@1224,1RMWP@1236,3XNP4@561,COG0021@1,COG0021@2	NA|NA|NA	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
b2466	316407.85675415	7.5e-202	709.5	Escherichia	ypfG												Escherichia	1MXZW@1224,1RQEU@1236,3XMJ9@561,COG5342@1,COG5342@2	NA|NA|NA	S	Protein of unknown function (DUF1176)
b2467	316407.1799890	1.8e-104	385.2	Escherichia	nudK	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0046872,GO:0052751		ko:K12945					ko00000,ko01000			iLF82_1304.LF82_1537,iNRG857_1313.NRG857_12310,iUTI89_1310.UTI89_C2793,ic_1306.c2994	Escherichia	1MWBQ@1224,1RPUY@1236,3XMBW@561,COG0494@1,COG0494@2	NA|NA|NA	L	GDP-mannose pyrophosphatase NudK
b2468	316407.85675416	0.0	1364.4	Escherichia	aegA												Escherichia	1MU2H@1224,1RMY7@1236,3XNKH@561,COG0493@1,COG0493@2,COG1142@1,COG1142@2	NA|NA|NA	C	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
b2469	316407.1799892	0.0	1088.9	Escherichia	narQ	GO:0000155,GO:0000160,GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071250,GO:0071704,GO:0071944,GO:0080033,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	2.7.13.3	ko:K07674	ko02020,map02020	M00472			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1MWZT@1224,1RNPP@1236,3XP39@561,COG3850@1,COG3850@2	NA|NA|NA	T	Acts as a sensor for nitrate nitrite and transduces signal of nitrate nitrite availability to the NarL NarP proteins. NarQ probably activates NarL and NarP by phosphorylation. NarQ probably negatively regulates the NarL protein by dephosphorylation
b2470	316407.1799893	0.0	1980.7	Escherichia	acrD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015307,GO:0015318,GO:0015672,GO:0015893,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K18324	ko02020,map02020	M00646			ko00000,ko00001,ko00002,ko02000	2.A.6.2.7		iE2348C_1286.E2348C_2706	Escherichia	1MU48@1224,1RMBN@1236,3XMEX@561,COG0841@1,COG0841@2	NA|NA|NA	U	efflux pump
b2471	316407.1799894	6.1e-63	246.5	Escherichia	yffB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MZ6S@1224,1S8TR@1236,3XPW3@561,COG1393@1,COG1393@2	NA|NA|NA	P	Belongs to the ArsC family
b2472	198214.SF2514	5.6e-219	766.5	Gammaproteobacteria													Escherichia	1MW6G@1224,1RMNQ@1236,COG0624@1,COG0624@2	NA|NA|NA	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
b4547	155864.EDL933_3627	4.5e-31	139.8	Escherichia	ypfN												Escherichia	1N76H@1224,1SCQS@1236,2C6G7@1,32YJI@2,3XPZP@561	NA|NA|NA	S	Uncharacterised protein family (UPF0370)
b2473	316407.85675417	1.4e-130	472.2	Escherichia	ypfH	GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0052689		ko:K06999					ko00000				Escherichia	1RA02@1224,1RN9I@1236,3XNQ7@561,COG0400@1,COG0400@2	NA|NA|NA	S	carboxylic ester hydrolase activity
b2474	316407.85675418	0.0	1361.7	Escherichia	tmcA	GO:0000049,GO:0000154,GO:0002097,GO:0002101,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008080,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0022613,GO:0030490,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0051391,GO:0051392,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1904812,GO:1990882,GO:1990883,GO:1990884	2.3.1.193	ko:K06957					ko00000,ko01000,ko03016				Escherichia	1NBA4@1224,1RPAM@1236,3XNM7@561,COG1444@1,COG1444@2	NA|NA|NA	J	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP)
b2475	155864.EDL933_3630	2e-163	581.6	Escherichia	ypfJ			ko:K07054					ko00000				Escherichia	1MU4U@1224,1RMF8@1236,3XMEM@561,COG2321@1,COG2321@2	NA|NA|NA	S	Putative neutral zinc metallopeptidase
b2476	1440052.EAKF1_ch3531	1.9e-132	478.4	Escherichia	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016881,GO:0044424,GO:0044444,GO:0044464	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000			iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iZ_1308.Z3735	Escherichia	1MUR9@1224,1RNNY@1236,3XMYR@561,COG0152@1,COG0152@2	NA|NA|NA	F	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
b2477	198214.SF2520	5.6e-189	666.8	Gammaproteobacteria													Escherichia	1MUUK@1224,1RN2X@1236,COG3317@1,COG3317@2	NA|NA|NA	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
b2478	198214.SF2521	3.4e-163	580.9	Gammaproteobacteria													Escherichia	1MUCM@1224,1RNH9@1236,COG0329@1,COG0329@2	NA|NA|NA	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
b2479	155864.EDL933_3634	9.2e-101	372.9	Escherichia	gcvR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K03567	ko02026,map02026				ko00000,ko00001,ko03000				Escherichia	1R7W7@1224,1RSDP@1236,3XN0Y@561,COG2716@1,COG2716@2	NA|NA|NA	K	Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how GcvR acts as a repressor. It does not seem to bind DNA. It could interact with GcvA and suppress its activatory activity
b2480	1440052.EAKF1_ch3527c	8.6e-89	332.8	Escherichia	bcp	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03564					ko00000,ko01000				Escherichia	1RD4R@1224,1RQ7F@1236,3XNFY@561,COG1225@1,COG1225@2	NA|NA|NA	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events
b2481	316407.1799909	8e-119	433.0	Escherichia	hyfA			ko:K12136					ko00000,ko01000			iEcolC_1368.EcolC_1195,iUMNK88_1353.UMNK88_3076	Escherichia	1QWC6@1224,1RPDJ@1236,3XRFF@561,COG1142@1,COG1142@2	NA|NA|NA	C	4Fe-4S binding domain
b2482	316407.1799910	0.0	1218.0	Escherichia	hyfB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K12137					ko00000,ko01000			iEKO11_1354.EKO11_1252	Escherichia	1MXRW@1224,1RM9Q@1236,3XMXV@561,COG0651@1,COG0651@2	NA|NA|NA	CP	Formate hydrogenlyase, subunit
b2483	316407.85675421	1.8e-165	588.6	Escherichia	hyfC	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K12138					ko00000,ko01000			iUMNK88_1353.UMNK88_3079	Escherichia	1MXV5@1224,1RPCY@1236,3XNSF@561,COG0650@1,COG0650@2	NA|NA|NA	C	oxidoreductase activity
b2484	316407.1805543	1.5e-261	908.3	Escherichia	hyfD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K12139					ko00000,ko01000			iEcSMS35_1347.EcSMS35_2631	Escherichia	1MW2M@1224,1RY6H@1236,3XQNF@561,COG1009@1,COG1009@2	NA|NA|NA	CP	hydrogenase 4
b2485	155864.EDL933_3640	1.8e-108	398.7	Escherichia	hyfE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K12140					ko00000,ko01000				Escherichia	1NAT8@1224,1RRYF@1236,3XQCF@561,COG4237@1,COG4237@2	NA|NA|NA	C	Hydrogenase-4 component E
b2486	316407.1805545	2e-278	964.5	Escherichia	hyfF	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0044425,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K12141					ko00000,ko01000			iECIAI39_1322.ECIAI39_2625,iZ_1308.Z3746	Escherichia	1MVBA@1224,1RPB3@1236,3XQE4@561,COG0651@1,COG0651@2	NA|NA|NA	CP	cellular response to DNA damage stimulus
b2487	316407.85675422	0.0	1136.3	Escherichia	hyfG			ko:K12142					ko00000,ko01000			iEcE24377_1341.EcE24377A_2769	Escherichia	1QUBF@1224,1RSJ4@1236,3XNB6@561,COG3261@1,COG3261@2,COG3262@1,COG3262@2	NA|NA|NA	C	nickel cation binding
b2488	316407.1805547	2e-84	318.5	Escherichia	hyfH			ko:K12143					ko00000				Escherichia	1R9YT@1224,1RQB1@1236,3XMEE@561,COG1143@1,COG1143@2	NA|NA|NA	C	electron transfer protein for hydrogenase
b2489	316407.85675423	1.9e-146	525.0	Escherichia	hyfI	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114		ko:K12144					ko00000,ko01000			iECSP_1301.ECSP_3428,iECs_1301.ECs3351	Escherichia	1QUBE@1224,1RNUG@1236,3XMV7@561,COG3260@1,COG3260@2	NA|NA|NA	C	Formate hydrogenlyase
b2490	316407.1805549	1.7e-72	278.5	Escherichia	hyfJ			ko:K12145					ko00000,ko01000			iECSP_1301.ECSP_3429	Escherichia	1RHQ7@1224,1S6TA@1236,2DBX5@1,2ZBMB@2,3XP4F@561	NA|NA|NA	E	formate hydrogenlyase maturation
b2491	316407.85675424	0.0	1324.7	Escherichia	hyfR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141		ko:K12146					ko00000,ko03000				Escherichia	1QTT3@1224,1T1G7@1236,3XN8S@561,COG3604@1,COG3604@2	NA|NA|NA	KT	Formate hydrogen-lyase transcriptional activator
b2492	316407.1805553	8.1e-154	549.7	Escherichia	focB	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015318,GO:0015499,GO:0015711,GO:0015718,GO:0015724,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K03459					ko00000,ko02000	1.A.16.1.2		iB21_1397.B21_02346,iECBD_1354.ECBD_1196,iECB_1328.ECB_02384,iECD_1391.ECD_02384,iECIAI39_1322.ECIAI39_2632,iEcSMS35_1347.EcSMS35_2639	Escherichia	1MU0W@1224,1RPXB@1236,3XRIU@561,COG2116@1,COG2116@2	NA|NA|NA	P	formate transporter
b2493	155864.EDL933_3648	1.2e-173	615.9	Escherichia	perM	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03548					ko00000,ko02000	2.A.86.1			Escherichia	1MW0B@1224,1RPVP@1236,3XMGI@561,COG0628@1,COG0628@2	NA|NA|NA	S	transporter activity
b2494	198214.SF2538	7e-270	936.0	Gammaproteobacteria													Escherichia	1MVFV@1224,1RP5S@1236,COG4783@1,COG4783@2	NA|NA|NA	S	Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state
b2495	316407.85675426	4.6e-58	230.3	Escherichia	yfgD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.20.4.1	ko:K00537					ko00000,ko01000				Escherichia	1MZ4Z@1224,1S8XH@1236,3XPP4@561,COG1393@1,COG1393@2	NA|NA|NA	P	oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor
b2496	155864.EDL933_3651	4.7e-131	473.8	Escherichia	hda	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043531,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113		ko:K10763					ko00000,ko03032				Escherichia	1MVW6@1224,1RPJP@1236,3XNZA@561,COG0593@1,COG0593@2	NA|NA|NA	J	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA
b2497	316407.1805557	2.9e-227	794.3	Escherichia	uraA	GO:0003674,GO:0005215,GO:0005350,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015205,GO:0015210,GO:0015238,GO:0015851,GO:0015855,GO:0015857,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072531,GO:1903791,GO:1904082		ko:K02824					ko00000,ko02000	2.A.40.1.1,2.A.40.1.2		iSFxv_1172.SFxv_2795,iS_1188.S2690	Escherichia	1MUN9@1224,1RRK5@1236,3XMK3@561,COG2233@1,COG2233@2	NA|NA|NA	F	permease
b2498	1440052.EAKF1_ch3521	5.3e-110	403.7	Escherichia	upp	GO:0003674,GO:0003824,GO:0004845,GO:0004849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016763,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100		R00966	RC00063	ko00000,ko00001,ko01000			iAF1260.b2498,iAPECO1_1312.APECO1_4071,iB21_1397.B21_02352,iBWG_1329.BWG_2262,iE2348C_1286.E2348C_2723,iEC042_1314.EC042_2699,iEC55989_1330.EC55989_2783,iECABU_c1320.ECABU_c27980,iECBD_1354.ECBD_1190,iECB_1328.ECB_02390,iECDH10B_1368.ECDH10B_2664,iECDH1ME8569_1439.ECDH1ME8569_2424,iECD_1391.ECD_02390,iECED1_1282.ECED1_2921,iECH74115_1262.ECH74115_3720,iECIAI1_1343.ECIAI1_2550,iECIAI39_1322.ECIAI39_2639,iECNA114_1301.ECNA114_2571,iECO103_1326.ECO103_3015,iECO111_1330.ECO111_3222,iECO26_1355.ECO26_3545,iECOK1_1307.ECOK1_2794,iECP_1309.ECP_2500,iECS88_1305.ECS88_2669,iECSE_1348.ECSE_2784,iECSF_1327.ECSF_2339,iECSP_1301.ECSP_3437,iECUMN_1333.ECUMN_2811,iECW_1372.ECW_m2721,iEKO11_1354.EKO11_1236,iETEC_1333.ETEC_2603,iEcDH1_1363.EcDH1_1171,iEcE24377_1341.EcE24377A_2781,iEcHS_1320.EcHS_A2633,iEcSMS35_1347.EcSMS35_2645,iEcolC_1368.EcolC_1178,iG2583_1286.G2583_3021,iJO1366.b2498,iJR904.b2498,iLF82_1304.LF82_2383,iNRG857_1313.NRG857_12410,iSFV_1184.SFV_2543,iSF_1195.SF2542,iS_1188.S2691,iSbBS512_1146.SbBS512_E2872,iUMN146_1321.UM146_04235,iUMNK88_1353.UMNK88_3094,iWFL_1372.ECW_m2721,iY75_1357.Y75_RS13040,ic_1306.c3015	Escherichia	1MV4N@1224,1RPBG@1236,3XMQQ@561,COG0035@1,COG0035@2	NA|NA|NA	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
b2499	316407.1805559	2.4e-200	704.5	Escherichia	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016882,GO:0044424,GO:0044444,GO:0044464	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000			iECSF_1327.ECSF_2340	Escherichia	1MURG@1224,1RNZZ@1236,3XP9U@561,COG0150@1,COG0150@2	NA|NA|NA	F	Phosphoribosylformylglycinamidine cyclo-ligase
b2500	316407.1805560	2.1e-117	428.3	Escherichia	purN	GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000			iAF1260.b2500,iBWG_1329.BWG_2264,iECDH10B_1368.ECDH10B_2666,iECDH1ME8569_1439.ECDH1ME8569_2426,iEcDH1_1363.EcDH1_1169,iJO1366.b2500,iJR904.b2500,iY75_1357.Y75_RS13050	Escherichia	1MWN1@1224,1RMHS@1236,3XMAB@561,COG0299@1,COG0299@2	NA|NA|NA	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
b2501	155864.EDL933_3657	0.0	1370.9	Escherichia	ppk	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006091,GO:0006139,GO:0006163,GO:0006165,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006757,GO:0006793,GO:0006796,GO:0006797,GO:0006799,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009279,GO:0009358,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016778,GO:0017144,GO:0019538,GO:0019637,GO:0019693,GO:0019867,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0032991,GO:0034641,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043751,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044425,GO:0044462,GO:0044464,GO:0046031,GO:0046034,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0061695,GO:0071704,GO:0071944,GO:0072521,GO:0098552,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1902494,GO:1990234	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018				ko00000,ko00001,ko01000,ko03019			iSbBS512_1146.SbBS512_E2875	Escherichia	1MUM3@1224,1RNRX@1236,3XN1S@561,COG0855@1,COG0855@2	NA|NA|NA	F	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
b2502	155864.EDL933_3658	3.5e-296	1023.5	Escherichia	ppx	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006082,GO:0006793,GO:0006797,GO:0006798,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0042802,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0071704,GO:1901575	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230		R03409	RC00002	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_2643	Escherichia	1MV35@1224,1RN3V@1236,3XNC4@561,COG0248@1,COG0248@2	NA|NA|NA	FP	Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain
b2503	316407.1805566	0.0	1472.2	Escherichia	yfgF	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008081,GO:0008150,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0016020,GO:0016021,GO:0016787,GO:0016788,GO:0031224,GO:0033554,GO:0034059,GO:0034599,GO:0034614,GO:0035690,GO:0036293,GO:0036294,GO:0042221,GO:0042493,GO:0042542,GO:0042578,GO:0043900,GO:0044425,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070301,GO:0070482,GO:0070887,GO:0071111,GO:0071236,GO:0071453,GO:0071454,GO:0071944,GO:0097237,GO:1900190,GO:1901700,GO:1901701											Escherichia	1N299@1224,1RN30@1236,3XMW8@561,COG2200@1,COG2200@2	NA|NA|NA	T	Truncated proteins consisting of the GGDEF EAL domains (residues 319-747) or of the EAL domain alone (481-747) have c-di- GMP phosphodiesterase activity. They do not have diguanylate cyclase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
b2504	1440052.EAKF1_ch3511c	1.2e-25	121.7	Escherichia	yfgG												Escherichia	1N7D5@1224,1SDVM@1236,2E49W@1,32Z5K@2,3XR8T@561	NA|NA|NA	S	Protein of unknown function (DUF2633)
b2505	316407.85675429	7.6e-62	243.4	Escherichia	yfgH	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944											Escherichia	1RFYG@1224,1S4YR@1236,3XNPC@561,COG3133@1,COG3133@2	NA|NA|NA	M	Glycine zipper
b2506	316407.85675430	2.6e-44	185.3	Escherichia	yfgI	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1RJM9@1224,1S7QM@1236,2AQ7C@1,31FD2@2,3XNKB@561	NA|NA|NA	S	cellular response to DNA damage stimulus
b2507	316407.1805567	2.2e-311	1074.3	Escherichia	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002			iSF_1195.SF2553,iSFxv_1172.SFxv_2808,iS_1188.S2725	Escherichia	1MU2A@1224,1RP81@1236,3XNP3@561,COG0518@1,COG0518@2,COG0519@1,COG0519@2	NA|NA|NA	F	Catalyzes the synthesis of GMP from XMP
b2508	1440052.EAKF1_ch3495c	1.9e-267	927.9	Escherichia	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147			iAPECO1_1312.APECO1_4018	Escherichia	1MUJM@1224,1RMT8@1236,3XNH9@561,COG0516@1,COG0516@2,COG0517@1,COG0517@2	NA|NA|NA	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
b2509	316407.1805569	5.8e-202	710.3	Escherichia	xseA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.1.11.6	ko:K03601	ko03430,map03430				ko00000,ko00001,ko01000,ko03400				Escherichia	1MUA4@1224,1RNAZ@1236,3XM63@561,COG1570@1,COG1570@2	NA|NA|NA	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
b2510	316407.85675432	5.4e-38	162.9	Gammaproteobacteria													Escherichia	1N9D9@1224,1SCH3@1236,COG1645@1,COG1645@2	NA|NA|NA	S	bacterial-type flagellum-dependent swarming motility
b2511	155864.EDL933_3668	4.4e-272	943.3	Escherichia	der	GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363		ko:K03977					ko00000,ko03009				Escherichia	1MU9S@1224,1RMSF@1236,3XPBZ@561,COG1160@1,COG1160@2	NA|NA|NA	J	GTPase that plays an essential role in the late steps of ribosome biogenesis
b2512	316407.1805571	2.2e-197	694.9	Escherichia	bamB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063		ko:K17713					ko00000,ko02000	1.B.33.1			Escherichia	1MXIJ@1224,1RN4V@1236,3XN9I@561,COG1520@1,COG1520@2	NA|NA|NA	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
b2513	316407.85675434	3e-105	387.9	Escherichia	yfgM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552											Escherichia	1N117@1224,1S95P@1236,3XMCB@561,COG2976@1,COG2976@2	NA|NA|NA	S	Tetratricopeptide repeat-like domain
b2514	155864.EDL933_3671	1.8e-245	854.7	Escherichia	hisS	GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358	Escherichia	1MV2K@1224,1RPHI@1236,3XMFB@561,COG0124@1,COG0124@2	NA|NA|NA	J	histidyl-tRNA aminoacylation
b2515	155864.EDL933_3672	3.5e-205	720.7	Escherichia	ispG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046429,GO:0046490,GO:0046872,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000			iAF1260.b2515,iAPECO1_1312.APECO1_4009,iB21_1397.B21_02369,iBWG_1329.BWG_2279,iE2348C_1286.E2348C_2798,iEC55989_1330.EC55989_2800,iECABU_c1320.ECABU_c28200,iECBD_1354.ECBD_1171,iECB_1328.ECB_02407,iECDH10B_1368.ECDH10B_2681,iECDH1ME8569_1439.ECDH1ME8569_2442,iECDH1ME8569_1439.EcDH1_1153,iECD_1391.ECD_02407,iECED1_1282.ECED1_2946,iECH74115_1262.ECH74115_3740,iECIAI39_1322.ECIAI39_2716,iECNA114_1301.ECNA114_2593,iECO103_1326.ECO103_3032,iECO111_1330.ECO111_3239,iECO26_1355.ECO26_3562,iECOK1_1307.ECOK1_2863,iECP_1309.ECP_2520,iECS88_1305.ECS88_2691,iECSE_1348.ECSE_2801,iECSF_1327.ECSF_2359,iECSP_1301.ECSP_3455,iECW_1372.ECW_m2740,iECs_1301.ECs3377,iEKO11_1354.EKO11_1218,iETEC_1333.ETEC_2672,iEcDH1_1363.EcDH1_1153,iEcE24377_1341.EcE24377A_2799,iEcolC_1368.EcolC_1162,iJO1366.b2515,iJR904.b2515,iLF82_1304.LF82_1130,iNRG857_1313.NRG857_12515,iUMN146_1321.UM146_04130,iUMNK88_1353.UMNK88_3165,iUTI89_1310.UTI89_C2836,iWFL_1372.ECW_m2740,iY75_1357.Y75_RS13130,iZ_1308.Z3778,ic_1306.c3037	Escherichia	1MUAX@1224,1RMXZ@1236,3XPHC@561,COG0821@1,COG0821@2	NA|NA|NA	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
b2516	155864.EDL933_3673	2.8e-121	441.8	Escherichia	rodZ	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944		ko:K15539					ko00000				Escherichia	1N240@1224,1RQMV@1236,3XNBZ@561,COG1426@1,COG1426@2	NA|NA|NA	S	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis
b2517	316407.1799916	2.8e-221	774.2	Escherichia	rlmN	GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363	2.1.1.192	ko:K06941					ko00000,ko01000,ko03009				Escherichia	1MUYK@1224,1RMUI@1236,3XMG3@561,COG0820@1,COG0820@2	NA|NA|NA	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
b2518	155864.EDL933_3675	3.8e-75	287.3	Escherichia	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131				Escherichia	1R9ZA@1224,1S1Z3@1236,3XPKC@561,COG0105@1,COG0105@2	NA|NA|NA	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
b2519	316407.85675436	0.0	1592.8	Escherichia	pbpC	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031406,GO:0033218,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051302,GO:0051781,GO:0065007,GO:0097159,GO:1901363,GO:1901681	2.4.1.129	ko:K05367	ko00550,map00550				ko00000,ko00001,ko01000,ko01003,ko01011		GT51	iE2348C_1286.E2348C_2802,iECO111_1330.ECO111_3243	Escherichia	1MUA9@1224,1RMBV@1236,3XMHY@561,COG4953@1,COG4953@2	NA|NA|NA	M	penicillin-binding protein 1C
b2520	316407.85675437	0.0	3257.6	Escherichia	yfhM	GO:0003674,GO:0004857,GO:0004866,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009892,GO:0009897,GO:0009986,GO:0010466,GO:0010605,GO:0010951,GO:0016020,GO:0019222,GO:0030162,GO:0030234,GO:0030414,GO:0031224,GO:0031225,GO:0031226,GO:0031233,GO:0031323,GO:0031324,GO:0031362,GO:0032268,GO:0032269,GO:0043086,GO:0044092,GO:0044425,GO:0044459,GO:0044464,GO:0045861,GO:0046658,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098772		ko:K06894					ko00000				Escherichia	1MV7J@1224,1RNRY@1236,3XN1J@561,COG2373@1,COG2373@2	NA|NA|NA	S	peptidase regulator activity
b2521	316407.85675438	3.9e-164	583.9	Escherichia	sseA	GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016782,GO:0016783,GO:0016784,GO:0031668,GO:0033554,GO:0034641,GO:0042221,GO:0042262,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122		R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000			iECs_1301.ECs3387,iZ_1308.Z3788	Escherichia	1MW4B@1224,1RSQ3@1236,3XMB1@561,COG2897@1,COG2897@2	NA|NA|NA	P	Its participation in detoxification of cyanide may be small. May be involved in the enhancement of serine sensitivity
b2522	198214.SF2569	2.9e-142	511.1	Gammaproteobacteria													Escherichia	1R4DR@1224,1RRDT@1236,28I6Y@1,2Z89T@2	NA|NA|NA	S	enhanced serine sensitivity protein SseB
b2523	316407.1799926	1.3e-248	865.1	Escherichia	pepB	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0042802,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.11.23	ko:K07751	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002			iAF1260.b2523,iBWG_1329.BWG_2287,iECDH10B_1368.ECDH10B_2690,iECDH1ME8569_1439.ECDH1ME8569_2450,iEcDH1_1363.EcDH1_1145,iJO1366.b2523,iY75_1357.Y75_RS13170	Escherichia	1MUIN@1224,1RNFI@1236,3XPE7@561,COG0260@1,COG0260@2	NA|NA|NA	E	Probably plays an important role in intracellular peptide degradation
b2524	155864.EDL933_3686	8.3e-33	145.6	Escherichia	iscX	GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772											Escherichia	1N7C1@1224,1SC9F@1236,3XPZ5@561,COG2975@1,COG2975@2	NA|NA|NA	S	May function as iron donor in the assembly of iron- sulfur clusters
b2525	155864.EDL933_3687	3e-59	234.2	Escherichia	fdx	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840		ko:K04755					ko00000				Escherichia	1RHDC@1224,1S5XW@1236,3XPTK@561,COG0633@1,COG0633@2	NA|NA|NA	C	that it has a role as a cellular electron transfer protein. Involved in the in vivo assembly of the Fe-S clusters in a wide variety of iron- sulfur proteins
b2526	155864.EDL933_3688	0.0	1163.7	Escherichia	hscA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051604,GO:0051716,GO:0070417,GO:0071704,GO:0097159,GO:0097367,GO:0097428,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1990230,GO:1990234		ko:K04044					ko00000,ko03110	1.A.33			Escherichia	1MVQI@1224,1RN74@1236,3XMUN@561,COG0443@1,COG0443@2	NA|NA|NA	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU
b2527	155864.EDL933_3689	8e-88	329.7	Escherichia	hscB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0032991,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051604,GO:0071704,GO:0097428,GO:1901564,GO:1902494,GO:1990230,GO:1990234		ko:K04082					ko00000,ko03029,ko03110				Escherichia	1RHZX@1224,1S9YH@1236,3XMB5@561,COG1076@1,COG1076@2	NA|NA|NA	O	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
b2528	1440052.EAKF1_ch3471	3.3e-55	220.7	Escherichia	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016530,GO:0019538,GO:0022607,GO:0031163,GO:0034986,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0097428,GO:0140104,GO:1901564		ko:K13628					ko00000,ko03016			iAPECO1_1312.APECO1_3997,iB21_1397.B21_02384,iBWG_1329.BWG_2292,iE2348C_1286.E2348C_2811,iEC042_1314.EC042_2732,iEC55989_1330.EC55989_2813,iECABU_c1320.ECABU_c28340,iECBD_1354.ECBD_1156,iECB_1328.ECB_02420,iECDH10B_1368.ECDH10B_2695,iECD_1391.ECD_02420,iECED1_1282.ECED1_2959,iECIAI1_1343.ECIAI1_2580,iECIAI39_1322.ECIAI39_2729,iECNA114_1301.ECNA114_2607,iECO103_1326.ECO103_3045,iECO111_1330.ECO111_3252,iECO26_1355.ECO26_3575,iECOK1_1307.ECOK1_2877,iECP_1309.ECP_2533,iECS88_1305.ECS88_2704,iECSE_1348.ECSE_2814,iECSF_1327.ECSF_2372,iECSP_1301.ECSP_3472,iECUMN_1333.ECUMN_2848,iECW_1372.ECW_m2754,iECs_1301.ECs3394,iEKO11_1354.EKO11_1205,iETEC_1333.ETEC_2685,iEcDH1_1363.EcDH1_1140,iEcSMS35_1347.EcSMS35_2681,iEcolC_1368.EcolC_1149,iG2583_1286.G2583_3058,iJO1366.b2528,iLF82_1304.LF82_1120,iNRG857_1313.NRG857_12580,iSBO_1134.SBO_2552,iSDY_1059.SDY_2724,iSF_1195.SF2575,iSSON_1240.SSON_2610,iS_1188.S2747,iUMN146_1321.UM146_04060,iUMNK88_1353.UMNK88_3181,iWFL_1372.ECW_m2754,iY75_1357.Y75_RS13195,iZ_1308.Z3795,ic_1306.c3053	Escherichia	1RH6T@1224,1S5XD@1236,3XPP7@561,COG0316@1,COG0316@2	NA|NA|NA	S	Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA TrxB
b2529	155864.EDL933_3692	1.1e-65	255.8	Escherichia	iscU	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0036455,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0097428,GO:0098771,GO:1901564		ko:K04488					ko00000			iAPECO1_1312.APECO1_3996,iB21_1397.B21_02385,iBWG_1329.BWG_2293,iE2348C_1286.E2348C_2812,iEC042_1314.EC042_2733,iEC55989_1330.EC55989_2814,iECABU_c1320.ECABU_c28350,iECBD_1354.ECBD_1155,iECB_1328.ECB_02421,iECDH10B_1368.ECDH10B_2696,iECDH1ME8569_1439.ECDH1ME8569_2456,iECD_1391.ECD_02421,iECED1_1282.ECED1_2960,iECH74115_1262.ECH74115_3761,iECIAI1_1343.ECIAI1_2581,iECIAI39_1322.ECIAI39_2730,iECNA114_1301.ECNA114_2608,iECO103_1326.ECO103_3046,iECO111_1330.ECO111_3253,iECO26_1355.ECO26_3576,iECOK1_1307.ECOK1_2878,iECP_1309.ECP_2534,iECS88_1305.ECS88_2705,iECSE_1348.ECSE_2815,iECSF_1327.ECSF_2373,iECSP_1301.ECSP_3473,iECUMN_1333.ECUMN_2849,iECW_1372.ECW_m2755,iECs_1301.ECs3395,iEKO11_1354.EKO11_1204,iETEC_1333.ETEC_2686,iEcDH1_1363.EcDH1_1139,iEcE24377_1341.EcE24377A_2814,iEcHS_1320.EcHS_A2680,iEcSMS35_1347.EcSMS35_2682,iEcolC_1368.EcolC_1148,iG2583_1286.G2583_3059,iJO1366.b2529,iSDY_1059.SDY_2725,iSFV_1184.SFV_2577,iSF_1195.SF2576,iSFxv_1172.SFxv_2832,iSSON_1240.SSON_2611,iS_1188.S2748,iUMN146_1321.UM146_04055,iUMNK88_1353.UMNK88_3182,iUTI89_1310.UTI89_C2851,iWFL_1372.ECW_m2755,iY75_1357.Y75_RS13200,iZ_1308.Z3796,ic_1306.c3055	Escherichia	1RD5K@1224,1S3P1@1236,3XPIY@561,COG0822@1,COG0822@2	NA|NA|NA	C	It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters
b2530	1440052.EAKF1_ch3469	5.3e-231	806.6	Escherichia	iscS	GO:0001522,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029				Escherichia	1MU1C@1224,1RNCD@1236,3XMZ0@561,COG1104@1,COG1104@2	NA|NA|NA	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate
b2531	155864.EDL933_3694	4.6e-85	320.5	Escherichia	iscR	GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141		ko:K13643					ko00000,ko03000				Escherichia	1RDA4@1224,1S3RW@1236,3XPCG@561,COG1959@1,COG1959@2	NA|NA|NA	K	Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins
b2532	198214.SF2579	7.4e-135	486.5	Gammaproteobacteria													Escherichia	1N47Y@1224,1RPD3@1236,COG0565@1,COG0565@2	NA|NA|NA	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
b2533	155864.EDL933_3696	7.4e-149	533.1	Escherichia	suhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0031403,GO:0031420,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0047954,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_2538	Escherichia	1MUQT@1224,1RNME@1236,3XNR1@561,COG0483@1,COG0483@2	NA|NA|NA	G	inositol metabolic process
b2534	316407.1799942	1.8e-164	585.1	Escherichia	yfhR			ko:K06889					ko00000				Escherichia	1RFAF@1224,1S2YT@1236,3XPC6@561,COG1073@1,COG1073@2	NA|NA|NA	S	Prolyl oligopeptidase family
b2535	155864.EDL933_3698	1.2e-246	858.6	Escherichia	csiE												Escherichia	1NFZH@1224,1RN8B@1236,3XMR7@561,COG3711@1,COG3711@2	NA|NA|NA	K	regulation of nucleic acid-templated transcription
b2536	316407.1799945	5.3e-209	733.4	Escherichia	hcaT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K05820					ko00000,ko02000	2.A.1.27		iECIAI39_1322.ECIAI39_2737,iEcSMS35_1347.EcSMS35_2688	Escherichia	1MVZI@1224,1RPBT@1236,3XMD3@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b2537	316407.85675441	2.5e-161	574.7	Escherichia	hcaR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K05817					ko00000,ko03000				Escherichia	1Q8UG@1224,1S05A@1236,3XRJD@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional activator of
b2538	155864.EDL933_3701	2.4e-280	970.7	Gammaproteobacteria													Escherichia	1N6MJ@1224,1RNCN@1236,COG4638@1,COG4638@2	NA|NA|NA	P	Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively
b2539	316407.1799957	5.8e-94	350.1	Gammaproteobacteria													Escherichia	1RANS@1224,1T1EB@1236,COG5517@1,COG5517@2	NA|NA|NA	Q	Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively
b2540	198214.SF2587	3.5e-57	227.3	Gammaproteobacteria													Escherichia	1N8PE@1224,1S6B0@1236,COG2146@1,COG2146@2	NA|NA|NA	P	Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP- dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin
b2541	316407.1799959	5.2e-150	537.0	Gammaproteobacteria													Escherichia	1N32I@1224,1RRJG@1236,COG1028@1,COG1028@2	NA|NA|NA	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family
b2542	316407.1799960	1.1e-223	782.3	Gammaproteobacteria													Escherichia	1NR3M@1224,1RN6P@1236,COG0446@1,COG0446@2	NA|NA|NA	P	pyridine nucleotide-disulphide oxidoreductase
b2543	198214.SF2590	6.2e-70	270.0	Gammaproteobacteria													Escherichia	1RBM0@1224,1T00T@1236,COG2259@1,COG2259@2	NA|NA|NA	S	SURF4 family
b2544	316407.85675442	3.4e-179	634.0	Escherichia	yphB	GO:0003674,GO:0003824,GO:0004034,GO:0005975,GO:0005996,GO:0006006,GO:0006012,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0033554,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0050896,GO:0051716,GO:0071704,GO:1901575											Escherichia	1RAQE@1224,1S03U@1236,3XP7P@561,COG2017@1,COG2017@2	NA|NA|NA	G	aldose 1-epimerase activity
b2545	316407.85675443	1.2e-210	738.8	Escherichia	yphC											iECW_1372.ECW_m2771,iWFL_1372.ECW_m2771	Escherichia	1MV9A@1224,1S0CK@1236,3XPEW@561,COG1063@1,COG1063@2	NA|NA|NA	E	zinc ion binding
b2546	316407.1799963	4.6e-148	530.8	Escherichia	yphD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K02057		M00221			ko00000,ko00002,ko02000	3.A.1.2			Escherichia	1PSTG@1224,1RSQZ@1236,3XQ7B@561,COG1172@1,COG1172@2	NA|NA|NA	G	Probably part of the binding-protein-dependent transport system YphDEF. Probably responsible for the translocation of the substrate across the membrane
b2547	316407.1799964	1.7e-279	968.0	Escherichia	yphE		3.6.3.17	ko:K02056		M00221			ko00000,ko00002,ko01000,ko02000	3.A.1.2			Escherichia	1MU22@1224,1S1ND@1236,3XNWJ@561,COG1129@1,COG1129@2	NA|NA|NA	P	ABC transporter, ATP-binding protein
b2548	316407.1799973	1e-176	625.9	Escherichia	yphF			ko:K02058		M00221			ko00000,ko00002,ko02000	3.A.1.2			Escherichia	1PCD4@1224,1RPZE@1236,3XNDR@561,COG1879@1,COG1879@2	NA|NA|NA	G	ABC transporter
b2549	316407.85675444	0.0	2281.1	Escherichia	yphG												Escherichia	1Q3TC@1224,1RRC8@1236,3XP8A@561,COG0457@1,COG0457@2	NA|NA|NA	S	Domain of unknown function (DUF5107)
b2550	316407.85675445	2.9e-234	817.4	Escherichia	yphH												Escherichia	1NFKM@1224,1RMWQ@1236,3XPFW@561,COG1940@1,COG1940@2	NA|NA|NA	K	ROK family
b2551	1440052.EAKF1_ch3453	4.4e-241	840.1	Escherichia	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000			iG2583_1286.G2583_3081	Escherichia	1MUIS@1224,1RMHQ@1236,3XN0E@561,COG0112@1,COG0112@2	NA|NA|NA	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
b2552	316407.1799976	7.2e-233	812.8	Escherichia	hmp	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008289,GO:0008941,GO:0009056,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0016705,GO:0016708,GO:0017144,GO:0020037,GO:0031406,GO:0032843,GO:0033293,GO:0033554,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0044237,GO:0044248,GO:0044270,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051213,GO:0051409,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0071500,GO:0071949,GO:0072593,GO:0097159,GO:1901265,GO:1901363,GO:2001057	1.14.12.17	ko:K05916	ko05132,map05132				ko00000,ko00001,ko01000			iECP_1309.ECP_2554	Escherichia	1MV41@1224,1RMPJ@1236,3XPAT@561,COG1017@1,COG1017@2,COG1018@1,COG1018@2	NA|NA|NA	C	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
b2553	1197719.A464_2673	1.2e-55	222.2	Salmonella													Escherichia	1RGWK@1224,1S67I@1236,3ZMCB@590,COG0347@1,COG0347@2	NA|NA|NA	K	Nitrogen regulatory protein P-II
b2554	155864.EDL933_3719	1.5e-247	861.7	Escherichia	glrR	GO:0000156,GO:0000160,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0035556,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K07715	ko02020,ko02024,map02020,map02024	M00502			ko00000,ko00001,ko00002,ko02022				Escherichia	1MU0N@1224,1RMCK@1236,3XNKS@561,COG2204@1,COG2204@2	NA|NA|NA	K	Member of the two-component regulatory system GlrR GlrK that up-regulates transcription of the glmY sRNA when cells enter the stationary growth phase. Regulates glmY transcription by binding to three conserved sites in the purL-glmY intergenic region
b2555	198214.SF2602	1.1e-130	472.6	Gammaproteobacteria													Escherichia	1RDX1@1224,1S4CU@1236,COG3170@1,COG3170@2	NA|NA|NA	NU	YfhG lipoprotein
b2556	316407.85675447	9.2e-243	845.9	Escherichia	glrK	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1N58A@1224,1RP34@1236,3XPCT@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
b2557	316407.85675448	0.0	2605.5	Escherichia	purL	GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,ic_1306.c3080	Escherichia	1MYN4@1224,1RMRN@1236,3XP1B@561,COG0046@1,COG0046@2,COG0047@1,COG0047@2	NA|NA|NA	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
b2558	481805.EcolC_1119	3.8e-298	1030.0	Escherichia	mltF	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031975,GO:0043170,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K18691					ko00000,ko01000,ko01011			iBWG_1329.BWG_2322,iEC042_1314.EC042_2762,iECDH1ME8569_1439.ECDH1ME8569_2485,iECNA114_1301.ECNA114_2631,iECP_1309.ECP_2560,iECSF_1327.ECSF_2397,iECW_1372.ECW_m2786,iEKO11_1354.EKO11_1175,iEcDH1_1363.EcDH1_1110,iEcHS_1320.EcHS_A2711,iEcolC_1368.EcolC_1119,iG2583_1286.G2583_3089,iJO1366.b2558,iSFxv_1172.SFxv_2861,iUMN146_1321.UM146_03930,iUMNK88_1353.UMNK88_3212,iUTI89_1310.UTI89_C2878,iWFL_1372.ECW_m2786,iY75_1357.Y75_RS13345	Escherichia	1MWDS@1224,1RM8W@1236,3XMKR@561,COG4623@1,COG4623@2	NA|NA|NA	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella
b2559	198214.SF2606	3.1e-92	344.4	Gammaproteobacteria													Escherichia	1RGU0@1224,1S60Z@1236,COG0590@1,COG0590@2	NA|NA|NA	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)
b2560	316407.85675451	2e-120	438.3	Escherichia	yfhB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0031224,GO:0031226,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	3.1.3.27	ko:K18697	ko00564,map00564		R02029	RC00017	ko00000,ko00001,ko01000				Escherichia	1MWA9@1224,1RXX9@1236,3XM5U@561,COG0560@1,COG0560@2	NA|NA|NA	E	phosphatidylglycerophosphatase activity
b2561	155864.EDL933_3726	1.6e-149	535.4	Escherichia	yfhH	GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141											Escherichia	1ND5W@1224,1RNCI@1236,3XNB2@561,COG1737@1,COG1737@2	NA|NA|NA	K	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator
b2562	316407.85675453	3.4e-47	193.7	Escherichia	yfhL												Escherichia	1MZ6H@1224,1S8ZV@1236,3XQ28@561,COG1145@1,COG1145@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
b2563	316407.85675454	1.6e-64	251.9	Escherichia	acpS	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	2.7.8.7	ko:K00997	ko00770,map00770		R01625	RC00002	ko00000,ko00001,ko01000				Escherichia	1MZBF@1224,1S98P@1236,3XPQ6@561,COG0736@1,COG0736@2	NA|NA|NA	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein
b2564	1440052.EAKF1_ch3438	2.4e-130	471.5	Escherichia	pdxJ	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000			iAF1260.b2564,iB21_1397.B21_02422,iBWG_1329.BWG_2328,iEC55989_1330.EC55989_2852,iECBD_1354.ECBD_1117,iECB_1328.ECB_02458,iECDH10B_1368.ECDH10B_2732,iECDH1ME8569_1439.ECDH1ME8569_2491,iECD_1391.ECD_02458,iECH74115_1262.ECH74115_3800,iECIAI1_1343.ECIAI1_2675,iECO103_1326.ECO103_3142,iECO111_1330.ECO111_3290,iECO26_1355.ECO26_3611,iECSE_1348.ECSE_2852,iECSP_1301.ECSP_3509,iECW_1372.ECW_m2792,iECs_1301.ECs3430,iEKO11_1354.EKO11_1169,iEcDH1_1363.EcDH1_1104,iEcE24377_1341.EcE24377A_2850,iEcHS_1320.EcHS_A2719,iEcolC_1368.EcolC_1113,iG2583_1286.G2583_3145,iJO1366.b2564,iJR904.b2564,iWFL_1372.ECW_m2792,iY75_1357.Y75_RS13390	Escherichia	1MU9W@1224,1RMS5@1236,3XP85@561,COG0854@1,COG0854@2	NA|NA|NA	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
b2565	155864.EDL933_3730	2.5e-135	488.0	Escherichia	recO	GO:0008150,GO:0009314,GO:0009628,GO:0050896		ko:K03584	ko03440,map03440				ko00000,ko00001,ko03400				Escherichia	1RHIC@1224,1RN8Y@1236,3XMYF@561,COG1381@1,COG1381@2	NA|NA|NA	L	Involved in DNA repair and RecF pathway recombination
b2566	316407.85675457	3.6e-168	597.4	Escherichia	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564		ko:K03595					ko00000,ko03009,ko03029				Escherichia	1MUKT@1224,1RN3A@1236,3XNW1@561,COG1159@1,COG1159@2	NA|NA|NA	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
b2567	155864.EDL933_3732	2.7e-123	448.0	Escherichia	rnc	GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205				ko00000,ko00001,ko01000,ko03009,ko03019,ko03036				Escherichia	1MUQ6@1224,1RN0C@1236,3XNWX@561,COG0571@1,COG0571@2	NA|NA|NA	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
b2568	316407.85675459	7.6e-188	662.9	Escherichia	lepB	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009987,GO:0010467,GO:0015643,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0017171,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060				ko00000,ko00001,ko01000,ko01002				Escherichia	1MXUF@1224,1RMHI@1236,3XM5W@561,COG0681@1,COG0681@2	NA|NA|NA	U	Belongs to the peptidase S26 family
b2569	155864.EDL933_3734	0.0	1184.1	Escherichia	lepA	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0006970,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009409,GO:0009628,GO:0009651,GO:0009987,GO:0010467,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0034641,GO:0034645,GO:0042802,GO:0043021,GO:0043023,GO:0043024,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K03596	ko05134,map05134				ko00000,ko00001				Escherichia	1MVZA@1224,1RPFB@1236,3XNWA@561,COG0481@1,COG0481@2	NA|NA|NA	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
b2570	316407.85675461	2.9e-76	291.2	Escherichia	rseC	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K03803					ko00000,ko03021				Escherichia	1N6QS@1224,1SCTM@1236,3XPGD@561,COG3086@1,COG3086@2	NA|NA|NA	T	Sigma-E factor regulatory protein RseC
b2571	155864.EDL933_3736	8.5e-176	622.9	Escherichia	rseB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0044464,GO:0045152		ko:K03598					ko00000,ko03021				Escherichia	1MUQ8@1224,1RNF3@1236,3XN4S@561,COG3026@1,COG3026@2	NA|NA|NA	T	Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS)
b2572	199310.c3096	5.2e-100	370.5	Escherichia	rseA	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141		ko:K03597					ko00000,ko03021				Escherichia	1R4U0@1224,1RN98@1236,3XMZ1@561,COG3073@1,COG3073@2	NA|NA|NA	T	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
b2573	1440052.EAKF1_ch3429	2.7e-100	371.3	Escherichia	rpoE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K03088					ko00000,ko03021				Escherichia	1MX7T@1224,1RN64@1236,3XNWB@561,COG1595@1,COG1595@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock and oxidative stress
b2574	316407.85675465	0.0	1112.8	Escherichia	nadB	GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000			iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iY75_1357.Y75_RS13445	Escherichia	1RBQW@1224,1RMMD@1236,3XMYY@561,COG0029@1,COG0029@2	NA|NA|NA	H	Catalyzes the oxidation of L-aspartate to iminoaspartate
b2575	316407.85675466	1.1e-138	499.2	Escherichia	yfiC	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016426,GO:0016430,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.223	ko:K15460					ko00000,ko01000,ko03016				Escherichia	1PC8R@1224,1RM8S@1236,3XM65@561,COG4123@1,COG4123@2	NA|NA|NA	J	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
b2576	316407.85675467	6.4e-230	803.1	Escherichia	srmB	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008143,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0033592,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070035,GO:0070717,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901363	3.6.4.13	ko:K05590					ko00000,ko01000,ko03009				Escherichia	1MU49@1224,1RMWA@1236,3XNKW@561,COG0513@1,COG0513@2	NA|NA|NA	F	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity
b2577	316407.85675468	9.9e-163	579.3	Escherichia	yfiE	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1P8X0@1224,1RPH4@1236,3XQM4@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
b2578	316407.1799982	9.4e-101	372.9	Escherichia	eamB	GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015318,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032973,GO:0033228,GO:0033229,GO:0034220,GO:0042883,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0140115,GO:1901682,GO:1903712,GO:1903825,GO:1905039		ko:K11249					ko00000,ko02000	2.A.76.1.4		iSFV_1184.SFV_2641,iSF_1195.SF2640,iS_1188.S2813	Escherichia	1RCFI@1224,1T02N@1236,3XQ56@561,COG1280@1,COG1280@2	NA|NA|NA	U	Cysteine O-acetylserine efflux protein
b2579	155864.EDL933_3744	1.6e-64	251.9	Escherichia	grcA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606		ko:K06866					ko00000			iSF_1195.SF2641,iSFxv_1172.SFxv_2898,iS_1188.S2814	Escherichia	1RDRB@1224,1S45G@1236,3XPJB@561,COG3445@1,COG3445@2	NA|NA|NA	S	Acts as a radical domain for damaged PFL and possibly other radical proteins
b2580	316407.1799984	8.1e-136	489.6	Escherichia	ung	GO:0003674,GO:0003824,GO:0004844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340				ko00000,ko00001,ko01000,ko03400				Escherichia	1MV80@1224,1RPDH@1236,3XMVQ@561,COG0692@1,COG0692@2	NA|NA|NA	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
b2581	155864.EDL933_3746	2.9e-198	697.6	Escherichia	yfiF	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360		ko:K03214					ko00000,ko01000,ko03009,ko03016				Escherichia	1MXGV@1224,1RNWQ@1236,3XP5W@561,COG0566@1,COG0566@2	NA|NA|NA	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
b2582	155864.EDL933_3747	9.4e-79	299.3	Escherichia	trxC	GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.1.8	ko:K03672					ko00000,ko01000,ko03110			iAF1260.b2582,iAPECO1_1312.APECO1_3950,iB21_1397.B21_02440,iBWG_1329.BWG_2346,iE2348C_1286.E2348C_2859,iEC55989_1330.EC55989_2872,iECABU_c1320.ECABU_c28840,iECBD_1354.ECBD_1098,iECB_1328.ECB_02476,iECDH10B_1368.ECDH10B_2750,iECDH1ME8569_1439.ECDH1ME8569_2509,iECD_1391.ECD_02476,iECH74115_1262.ECH74115_3819,iECIAI1_1343.ECIAI1_2700,iECIAI39_1322.ECIAI39_2790,iECO103_1326.ECO103_3161,iECO111_1330.ECO111_3308,iECO26_1355.ECO26_3629,iECOK1_1307.ECOK1_2926,iECP_1309.ECP_2584,iECS88_1305.ECS88_2757,iECSE_1348.ECSE_2871,iECSF_1327.ECSF_2421,iECSP_1301.ECSP_3529,iECW_1372.ECW_m2811,iECs_1301.ECs3448,iEKO11_1354.EKO11_1151,iEcDH1_1363.EcDH1_1086,iEcE24377_1341.EcE24377A_2869,iEcHS_1320.EcHS_A2739,iEcSMS35_1347.EcSMS35_2735,iEcolC_1368.EcolC_1095,iG2583_1286.G2583_3165,iJO1366.b2582,iLF82_1304.LF82_2324,iNRG857_1313.NRG857_12825,iSDY_1059.SDY_2825,iSFV_1184.SFV_2645,iSF_1195.SF2644,iSFxv_1172.SFxv_2901,iSSON_1240.SSON_2708,iS_1188.S2817,iSbBS512_1146.SbBS512_E2954,iUMN146_1321.UM146_03805,iUMNK88_1353.UMNK88_3235,iUTI89_1310.UTI89_C2905,iWFL_1372.ECW_m2811,iY75_1357.Y75_RS13495,iZ_1308.Z3867,ic_1306.c3107	Escherichia	1RHUA@1224,1S64W@1236,3XP1C@561,COG3118@1,COG3118@2	NA|NA|NA	O	Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin
b2583	316407.85675471	5.7e-129	466.8	Escherichia	yfiP			ko:K05812					ko00000				Escherichia	1N8XY@1224,1RS6H@1236,3XMFX@561,COG3148@1,COG3148@2	NA|NA|NA	S	DTW
b2584	316407.85675472	0.0	1738.8	Escherichia	yfiQ	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564		ko:K09181					ko00000				Escherichia	1MW98@1224,1RPXX@1236,3XPBY@561,COG0045@1,COG0045@2,COG1042@1,COG1042@2,COG1670@1,COG1670@2	NA|NA|NA	CJ	Acetylates RNase R in exponential phase cells. Also required for the glucose-dependent acetylation on multiple lysines of alpha, beta and beta' RNAP subunits. May acetylate Acs and inhibit its activity
b2585	155864.EDL933_3750	3.4e-263	913.7	Escherichia	pssA	GO:0003674,GO:0003824,GO:0003882,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.8.8	ko:K00998	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_3822,iECSP_1301.ECSP_3532	Escherichia	1MVPU@1224,1RN1V@1236,3XP42@561,COG1502@1,COG1502@2	NA|NA|NA	I	CDP-diacylglycerol-serine O-phosphatidyltransferase activity
b2586	511145.b2586	1.5e-55	221.9	Escherichia	yfiM			ko:K05811					ko00000				Escherichia	1N1EG@1224,1S9DQ@1236,3XPUA@561,COG5544@1,COG5544@2	NA|NA|NA	S	Predicted periplasmic lipoprotein (DUF2279)
b2587	198214.SF2649	7.4e-239	832.8	Gammaproteobacteria													Escherichia	1MVZG@1224,1RS8V@1236,COG0477@1,COG0477@2	NA|NA|NA	EGP	transporter
b2592	155864.EDL933_3755	0.0	1640.2	Escherichia	clpB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0035966,GO:0042221,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896		ko:K03695	ko04213,map04213				ko00000,ko00001,ko03110				Escherichia	1MURH@1224,1RN55@1236,3XN3I@561,COG0542@1,COG0542@2	NA|NA|NA	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE
b2593	316407.1799996	1.4e-141	508.8	Escherichia	yfiH	GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114		ko:K05810					ko00000,ko01000				Escherichia	1MW2H@1224,1RNV4@1236,3XPG0@561,COG1496@1,COG1496@2	NA|NA|NA	S	Belongs to the multicopper oxidase YfiH RL5 family
b2594	316407.85675474	2.4e-186	657.9	Escherichia	rluD	GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180					ko00000,ko01000,ko03009			iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432	Escherichia	1MUBN@1224,1RN7F@1236,3XNUW@561,COG0564@1,COG0564@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil
b2595	155864.EDL933_3758	2.3e-136	491.5	Escherichia	bamD	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063		ko:K05807					ko00000,ko02000	1.B.33.1			Escherichia	1MVS5@1224,1RSE6@1236,3XN5M@561,COG4105@1,COG4105@2	NA|NA|NA	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery
b2597	1440052.EAKF1_ch3398c	9.1e-56	222.6	Escherichia	raiA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006446,GO:0006448,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113		ko:K05809					ko00000,ko03009				Escherichia	1RD2Y@1224,1S6GT@1236,3XPTC@561,COG1544@1,COG1544@2	NA|NA|NA	J	During stationary phase prevents 70S dimer formation, probably in order to regulate translation efficiency during transition between the exponential and the stationary phases. During environmental stress such as cold shock or excessive cell density at stationary phase, stabilizes the 70S ribosome against dissociation, inhibits translation elongation and increases translation accuracy. When normal growth conditions are restored, is quickly released from the ribosome. Has been suggested to inhibit translation elongation by blocking the A-site (aminoacyl-tRNA site). Has also been suggested to inhibit translation initiation by blocking the A-site and P-site (peptidyl-tRNA site) of the ribosome. At 15 degrees Celsius binds 30S subunits and stimulates their association with 50S subunits into idle 70S ribosomes. Crystallization with T.thermophilus 70S ribosomes shows it binds in the channel between the head and body of the 30S subunit, where mRNA, tRNAs, initiation factors IF1 and IF3 and elongation factor G would bind
b2599	155864.EDL933_3760	1.6e-213	748.4	Escherichia	pheA	GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_2667	Escherichia	1MU60@1224,1RNRD@1236,3XNP0@561,COG0077@1,COG0077@2,COG1605@1,COG1605@2	NA|NA|NA	E	Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation dehydration of prephenate to phenylpyruvate
b2600	316407.85675476	2.1e-210	738.0	Escherichia	tyrA	GO:0000166,GO:0003674,GO:0003824,GO:0004106,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	1.3.1.12,5.4.99.5	ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00024,M00025	R01715,R01728	RC00125,RC03116	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_2925	Escherichia	1MVUT@1224,1RQB3@1236,3XNQD@561,COG0287@1,COG0287@2,COG1605@1,COG1605@2	NA|NA|NA	E	T-protein
b2601	316407.1800007	2.7e-202	711.1	Escherichia	aroF	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_3932,iECOK1_1307.ECOK1_2946,iECS88_1305.ECS88_2787,iUMN146_1321.UM146_03705,iUTI89_1310.UTI89_C2934	Escherichia	1MU5Q@1224,1RMAA@1236,3XMUR@561,COG0722@1,COG0722@2	NA|NA|NA	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
b2602	316407.1800008	1.7e-63	248.4	Escherichia	yfiL												Escherichia	1N2Z7@1224,1SEVD@1236,2ED5M@1,3372C@2,3XPR7@561	NA|NA|NA	S	Protein of unknown function (DUF2799)
b2603	155864.EDL933_3764	9.2e-92	342.8	Escherichia	yfiR	GO:0001539,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588											Escherichia	1N04T@1224,1S4KR@1236,2BSVP@1,32MZ8@2,3XPY8@561	NA|NA|NA	S	bacterial-type flagellum-dependent swarming motility
b2604	316407.85675478	2.1e-227	794.7	Escherichia	yfiN	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0032153,GO:0032879,GO:0033554,GO:0036460,GO:0040012,GO:0040013,GO:0042802,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051270,GO:0051271,GO:0051716,GO:0052621,GO:0065007,GO:0071944,GO:1902021,GO:1902201,GO:2000145,GO:2000146	2.7.7.65	ko:K21021	ko02025,map02025				ko00000,ko00001,ko01000				Escherichia	1MXY1@1224,1RXYD@1236,3XMQ6@561,COG2199@1,COG2199@2	NA|NA|NA	T	cellular response to cell envelope stress
b2605	316407.1800010	5.9e-85	320.1	Escherichia	yfiB												Escherichia	1RJ05@1224,1S695@1236,3XNC2@561,COG2885@1,COG2885@2	NA|NA|NA	M	Belongs to the ompA family
b2606	155864.EDL933_3767	9.3e-56	222.6	Escherichia	rplS	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1990904		ko:K02884	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1RH3A@1224,1S5XX@1236,3XPQX@561,COG0335@1,COG0335@2	NA|NA|NA	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
b2607	155864.EDL933_3768	1.6e-145	521.9	Escherichia	trmD	GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554			R00597	RC00003,RC00334	ko00000,ko01000,ko03016				Escherichia	1MUN1@1224,1RMWC@1236,3XM2W@561,COG0336@1,COG0336@2	NA|NA|NA	J	Belongs to the RNA methyltransferase TrmD family
b2608	155864.EDL933_3769	1.2e-102	379.0	Escherichia	rimM	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360		ko:K02860					ko00000,ko03009				Escherichia	1MWQR@1224,1RNJ2@1236,3XNNP@561,COG0806@1,COG0806@2	NA|NA|NA	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
b2609	1440052.EAKF1_ch3387	1.6e-38	164.9	Escherichia	rpsP	GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02959	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03029				Escherichia	1MZCT@1224,1S8RT@1236,3XPX7@561,COG0228@1,COG0228@2	NA|NA|NA	J	In addition to being a ribosomal protein, S16 also has a cation-dependent endonuclease activity
b2610	155864.EDL933_3771	3.1e-248	864.0	Escherichia	ffh	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9			Escherichia	1MVIA@1224,1RMU9@1236,3XNYY@561,COG0541@1,COG0541@2	NA|NA|NA	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
b2611	155864.EDL933_3772	1.6e-140	505.4	Escherichia	ypjD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1R3YD@1224,1RPUQ@1236,3XP10@561,COG4137@1,COG4137@2	NA|NA|NA	S	cytochrome complex assembly
b4461	511145.b4461	3.4e-220	770.8	Escherichia	yfjD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1NZ99@1224,1RNCE@1236,3XMRP@561,COG4536@1,COG4536@2	NA|NA|NA	P	flavin adenine dinucleotide binding
b2614	316407.1800018	2.2e-97	361.7	Escherichia	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030554,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071840,GO:0097159,GO:0098772,GO:1901265,GO:1901363		ko:K03687					ko00000,ko03029,ko03110				Escherichia	1RH8T@1224,1S5W5@1236,3XM4I@561,COG0576@1,COG0576@2	NA|NA|NA	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
b2615	198214.SF2674	9.6e-166	589.3	Gammaproteobacteria													Escherichia	1MUBC@1224,1RP84@1236,COG0061@1,COG0061@2	NA|NA|NA	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
b2616	316407.1800021	8.6e-309	1065.4	Escherichia	recN	GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360		ko:K03631					ko00000,ko03400				Escherichia	1MUNP@1224,1RNPZ@1236,3XM2H@561,COG0497@1,COG0497@2	NA|NA|NA	L	May be involved in recombinational repair of damaged DNA
b2617	1440052.EAKF1_ch3378c	2.2e-57	228.0	Escherichia	bamE	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0030674,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042221,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045203,GO:0045229,GO:0046677,GO:0050896,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0060090,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063		ko:K06186					ko00000,ko02000	1.B.33.1			Escherichia	1N6YW@1224,1SCTT@1236,3XPQ8@561,COG2913@1,COG2913@2	NA|NA|NA	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
b2618	316407.1800023	2.3e-44	184.5	Escherichia	rnfH			ko:K09801					ko00000				Escherichia	1MZCH@1224,1SCHG@1236,3XPXJ@561,COG2914@1,COG2914@2	NA|NA|NA	S	RnfH family Ubiquitin
b2619	316407.1800024	1e-81	309.3	Escherichia	yfjG	GO:0003674,GO:0005488,GO:0006417,GO:0006446,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044877,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113											Escherichia	1RGUH@1224,1S61C@1236,3XNWI@561,COG2867@1,COG2867@2	NA|NA|NA	I	Toxic component of a type II toxin-antitoxin (TA) system. Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes and reducing polysomes. It does not cause ribosomes to dissociate however. The antibiotic paromomycin blocks the anti-association activity of RatA. Overexpression results in inhibition of growth in liquid cultures, and in a decrease in protein translation. The other gene of this operon, ratB, is not the cognate antitoxin in this strain
b2620	1440052.EAKF1_ch3375c	4.1e-86	323.9	Escherichia	smpB	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564		ko:K03664					ko00000				Escherichia	1RDFP@1224,1S3PT@1236,3XN6W@561,COG0691@1,COG0691@2	NA|NA|NA	J	the nascent peptide is terminated with the tag peptide encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans- translation
b2622	316407.85675485	8e-235	819.3	Escherichia	intA	GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0008979,GO:0009009,GO:0009987,GO:0015074,GO:0016032,GO:0019012,GO:0019015,GO:0019038,GO:0019042,GO:0019043,GO:0019045,GO:0019046,GO:0032359,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044403,GO:0044419,GO:0044423,GO:0046483,GO:0051704,GO:0071704,GO:0075713,GO:0090304,GO:0140097,GO:1901360											Escherichia	1MU23@1224,1RMJ1@1236,3XPHQ@561,COG0582@1,COG0582@2	NA|NA|NA	L	Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome. Part of the cryptic P4-like prophage CP4-57, it excises the prophage when overexpressed, which also requires integration host factor (encoded by ihfA and ihfB). Overexpression of AlpA leads to excision of the CP4-57 prophage, which inactivates ssrA (the gene upstream of the prophage) that encodes tmRNA which is required to rescue stalled ribosomes in a process known as trans-translation
b2623	316407.85675486	1.2e-185	655.6	Gammaproteobacteria													Escherichia	1RKGE@1224,1S85A@1236,2BVJ4@1,32QX4@2	NA|NA|NA		
b2624	316407.85675487	1e-33	148.7	Gammaproteobacteria													Escherichia	1NGB9@1224,1SCC0@1236,COG3311@1,COG3311@2	NA|NA|NA	K	Positive regulator of the expression of the slpA gene. When overexpressed, leads to suppression of the capsule overproduction and UV sensitivity phenotypes of cells mutant for the Lon ATP-dependent protease. Part of the cryptic P4-like prophage CP4-57. Overexpression of AlpA leads to excision of the CP4-57 prophage by IntA. This inactivates ssrA (the gene upstream of the prophage) that encodes tmRNA which is required to rescue stalled ribosomes in a process known as trans-translation
b2625	316407.85675488	6.9e-275	952.6	Escherichia	yfjI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N636@1224,1RZVN@1236,3XQNP@561,COG4983@1,COG4983@2	NA|NA|NA	S	Protein of unknown function (DUF3987)
b2626	316407.85675489	7.4e-120	436.4	Gammaproteobacteria													Escherichia	1MZGE@1224,1S91C@1236,2CZQX@1,32T6W@2	NA|NA|NA	S	Inovirus Gp2
b2627	316407.85675490	0.0	1458.4	Gammaproteobacteria													Escherichia	1N8A5@1224,1S0UU@1236,COG1204@1,COG1204@2	NA|NA|NA	L	COG1204 Superfamily II helicase
b2628	316407.85675491	0.0	1085.5	Gammaproteobacteria													Escherichia	1R7KJ@1224,1RQN7@1236,28JS0@1,2Z9HJ@2	NA|NA|NA	S	immune system process
b2629	316407.85675492	1.1e-43	182.2	Bacteria													Escherichia	COG1479@1,COG1479@2	NA|NA|NA	U	Protein of unknown function DUF262
b2630	316407.85675493	2.9e-201	707.6	Gammaproteobacteria													Escherichia	1R700@1224,1RR07@1236,2DBPX@1,2ZABA@2	NA|NA|NA	S	Toxic component of a type II toxin-antitoxin (TA) system. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd. Targets cyaA mRNA
b2631	316407.85675494	3.2e-62	244.2	Gammaproteobacteria													Escherichia	1NFGK@1224,1SEC4@1236,2DPCZ@1,331J3@2	NA|NA|NA	S	negative regulation of ribonuclease activity
b2632	316407.85675495	2.4e-161	574.7	Escherichia	yfjP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K06946					ko00000				Escherichia	1NG19@1224,1RPV6@1236,3XPY9@561,COG3596@1,COG3596@2	NA|NA|NA	S	GTP binding
b2633	316407.85675496	5.1e-153	547.0	Escherichia	yfjQ												Escherichia	1MVTR@1224,1RMPH@1236,28H9R@1,2Z7MD@2,3XNIG@561	NA|NA|NA	S	Escherichia coli O157 H7 ortholog z1655
b2634	316407.85675497	1.4e-127	462.2	Escherichia	yfjR	GO:0008150,GO:0043900,GO:0050789,GO:0050794,GO:0065007,GO:1900190											Escherichia	1R5FT@1224,1RZ7B@1236,3XQBJ@561,COG2378@1,COG2378@2	NA|NA|NA	K	regulation of single-species biofilm formation
b2636	316407.85675499	9e-80	302.8	Gammaproteobacteria													Escherichia	1N1WD@1224,1SAH1@1236,32TZC@2,COG2378@1	NA|NA|NA	K	regulation of single-species biofilm formation
b2637	316407.85675500	1.2e-85	322.4	Gammaproteobacteria													Escherichia	1RFAT@1224,1S45U@1236,2DKYD@1,30VQ4@2	NA|NA|NA		
b2638	316407.85675501	1.2e-54	218.8	Bacteria													Escherichia	COG1393@1,COG1393@2	NA|NA|NA	P	arsenate reductase (glutaredoxin) activity
b2642	316407.1800032	1.8e-309	1067.8	Gammaproteobacteria													Escherichia	1NSSM@1224,1SN1I@1236,2EYUX@1,33S22@2	NA|NA|NA		
b2643	316407.1800033	1.9e-88	331.6	Escherichia	yfjX												Escherichia	1REBZ@1224,1S3SZ@1236,2921C@1,2ZPKK@2,3XQ53@561	NA|NA|NA	S	Escherichia coli O157 H7 ortholog z1656
b2644	316407.1800034	1.2e-82	312.4	Escherichia	yfjY			ko:K03630					ko00000				Escherichia	1MW2D@1224,1S0RG@1236,3XQMM@561,COG2003@1,COG2003@2	NA|NA|NA	E	Belongs to the UPF0758 family
b4548	1115512.EH105704_26_00290	1.5e-26	124.8	Escherichia	ykfH												Escherichia	1N2MQ@1224,1S8RA@1236,2CZYD@1,32T7D@2,3XR6D@561	NA|NA|NA	S	Protein of unknown function (DUF987)
b2645	316407.1800035	3.4e-57	227.3	Escherichia	yfjZ			ko:K18838					ko00000,ko02048				Escherichia	1RDY9@1224,1S3T9@1236,2BMAS@1,304F4@2,3XR2A@561	NA|NA|NA	S	Might be an antitoxin component of a type II toxin- antitoxin (TA) system. A
b2646	316407.85675505	2.6e-55	221.1	Escherichia	ypjF			ko:K18837					ko00000,ko02048				Escherichia	1RG1Q@1224,1S7SE@1236,2C4I5@1,30CTH@2,3XRKR@561	NA|NA|NA	S	Toxic component of a type II toxin-antitoxin (TA) system. Overexpression results in inhibition of growth in liquid cultures. Might be inactivated by
b2647	316407.85675506	0.0	1742.2	Escherichia	ypjA												Escherichia	1R9A8@1224,1RS0C@1236,3XQQT@561,COG3468@1,COG3468@2	NA|NA|NA	MU	cell adhesion
b2648	316407.1651570	4.8e-11	73.6	Escherichia	pinE	GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360											Escherichia	1MXXT@1224,1S08N@1236,3XQEI@561,COG1961@1,COG1961@2	NA|NA|NA	L	This protein catalyzes the inversion of an 1800-bp E.coli DNA fragment, the P region, which can exist in either orientation. The function of the inversion is not yet clear
b4462	481805.EcolC_1048	0.0	1222.2	Escherichia													Escherichia	1QFX7@1224,1TD8F@1236,3XQ81@561,COG0366@1,COG0366@2	NA|NA|NA	G	Alpha amylase, catalytic domain
b2659	316407.85675512	2.4e-186	657.9	Escherichia	csiD	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0006950,GO:0008150,GO:0009605,GO:0009987,GO:0009991,GO:0016043,GO:0022607,GO:0031667,GO:0042594,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071840,GO:0090549		ko:K15737					ko00000				Escherichia	1MVXD@1224,1RQ5B@1236,2CG84@1,2Z8GB@2,3XQA6@561	NA|NA|NA	C	May be involved in the control of utilization of gamma- aminobutyric acid
b2660	316407.1800044	1.8e-245	854.7	Escherichia	lhgO	GO:0000166,GO:0003674,GO:0003824,GO:0003973,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0016899,GO:0034419,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071944,GO:0097159,GO:1901265,GO:1901363		ko:K15736					ko00000,ko01000				Escherichia	1N0QB@1224,1RN24@1236,3XPBR@561,COG0579@1,COG0579@2	NA|NA|NA	C	L-2-hydroxyglutarate oxidase LhgO
b2661	316407.85675513	8.4e-276	955.7	Escherichia	gabD	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019752,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_2847	Escherichia	1MU1V@1224,1RMBQ@1236,3XN8N@561,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
b2662	316407.1800048	9.8e-244	849.0	Escherichia	gabT	GO:0001505,GO:0003674,GO:0003824,GO:0003867,GO:0003992,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009084,GO:0009448,GO:0009450,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0042450,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007			iEC55989_1330.EC55989_2930,iECIAI1_1343.ECIAI1_2758,iECO111_1330.ECO111_3386,iECO26_1355.ECO26_3731	Escherichia	1MWY6@1224,1RMP0@1236,3XNUA@561,COG0160@1,COG0160@2	NA|NA|NA	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
b2663	316407.1800049	9.3e-256	889.0	Escherichia	gabP	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K11735					ko00000,ko02000	2.A.3.1.4,2.A.3.1.5		iAPECO1_1312.APECO1_3857,iECABU_c1320.ECABU_c29260,iLF82_1304.LF82_0783,iNRG857_1313.NRG857_13035,iUTI89_1310.UTI89_C3018	Escherichia	1MUPS@1224,1RP97@1236,3XPEK@561,COG1113@1,COG1113@2	NA|NA|NA	E	4-amino butyrate transport carrier
b2664	155864.EDL933_3827	1.1e-118	432.6	Escherichia	csiR	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K15735					ko00000,ko03000				Escherichia	1Q85H@1224,1RZ0B@1236,3XNYQ@561,COG1802@1,COG1802@2	NA|NA|NA	K	Modulates expression of csiD and lhgO in a temporal manner during entry into stationary phase or during the first few hours of carbon starvation
b2665	199310.c3213	5.5e-77	293.5	Escherichia	ygaU	GO:0003674,GO:0005488,GO:0008150,GO:0010035,GO:0010038,GO:0030955,GO:0031420,GO:0035864,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896											Escherichia	1RD8K@1224,1S4CB@1236,3XPJS@561,COG1652@1,COG1652@2	NA|NA|NA	S	response to potassium ion
b2666	155864.EDL933_3829	3e-22	110.2	Escherichia	yqaE												Escherichia	1N7K3@1224,1SCD8@1236,3XQ3S@561,COG0401@1,COG0401@2	NA|NA|NA	S	Proteolipid membrane potential modulator
b2667	316407.1800053	4.1e-44	183.7	Escherichia	ygaV	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0044212,GO:0097159,GO:1901363											Escherichia	1N72Q@1224,1SCH5@1236,3XPXI@561,COG0640@1,COG0640@2	NA|NA|NA	K	Transcriptional regulator
b2668	316407.85675515	2.4e-92	344.7	Escherichia	ygaP	GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016740,GO:0016782,GO:0016783,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Escherichia	1RDIR@1224,1S3VJ@1236,3XMZ5@561,COG0607@1,COG0607@2	NA|NA|NA	P	thiosulfate sulfurtransferase activity
b2669	155864.EDL933_3832	1.4e-58	232.3	Escherichia	stpA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363		ko:K11685					ko00000,ko03036				Escherichia	1RE55@1224,1S6P8@1236,3XPN4@561,COG2916@1,COG2916@2	NA|NA|NA	K	Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS StpA and may also modulate the oligomerization of the H-NS StpA-complex. Repression can be inhibited by dominant-negative mutants of StpA or H-NS
b2670	155864.EDL933_3834	8.5e-78	296.2	Escherichia	alaE	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015078,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015562,GO:0015672,GO:0015711,GO:0015804,GO:0015807,GO:0015808,GO:0015849,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0032328,GO:0034220,GO:0034639,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902475,GO:1902600,GO:1903825,GO:1905039											Escherichia	1RF8A@1224,1RZCB@1236,2940Y@1,2ZRFS@2,3XP5F@561	NA|NA|NA	U	L-alanine exporter AlaE
b2671	155864.EDL933_3835	1.4e-59	235.3	Escherichia	ygaC												Escherichia	1REJU@1224,1S4HA@1236,2DF7E@1,2ZQRR@2,3XPQW@561	NA|NA|NA	S	Protein of unknown function (DUF2002)
b2672	155864.EDL933_3836	3.5e-52	210.7	Escherichia	ygaM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1RI01@1224,1S88Q@1236,3XPQJ@561,COG4575@1,COG4575@2	NA|NA|NA	S	ribosome binding
b2673	155864.EDL933_3839	1e-40	172.2	Escherichia	nrdH	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009893,GO:0009987,GO:0016491,GO:0019222,GO:0019725,GO:0022900,GO:0042592,GO:0043085,GO:0044093,GO:0044237,GO:0045454,GO:0048518,GO:0050789,GO:0050790,GO:0050794,GO:0051341,GO:0051353,GO:0055114,GO:0065007,GO:0065008,GO:0065009		ko:K06191					ko00000				Escherichia	1N7YD@1224,1SCFR@1236,3XQ1Y@561,COG0695@1,COG0695@2	NA|NA|NA	O	Electron transport system for the ribonucleotide reductase system NrdEF
b2674	155864.EDL933_3840	3.4e-73	280.8	Escherichia	nrdI	GO:0000166,GO:0003674,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010181,GO:0019538,GO:0032553,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564		ko:K03647					ko00000				Escherichia	1RGYF@1224,1S3ZY@1236,3XPJI@561,COG1780@1,COG1780@2	NA|NA|NA	F	Probably involved in ribonucleotide reductase function
b2675	316407.85675520	0.0	1432.2	Escherichia	nrdE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0015949,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400			iAPECO1_1312.APECO1_3846	Escherichia	1MUJ8@1224,1RQQ6@1236,3XM5G@561,COG0209@1,COG0209@2	NA|NA|NA	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
b2676	316407.1800064	5.5e-183	646.7	Escherichia	nrdF	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0030145,GO:0032991,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400			iECNA114_1301.ECNA114_2708,iECSF_1327.ECSF_2473,iSFV_1184.SFV_2827,iSF_1195.SF2704,iSFxv_1172.SFxv_2966,iS_1188.S2890	Escherichia	1MWUS@1224,1RN2N@1236,3XNJX@561,COG0208@1,COG0208@2	NA|NA|NA	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
b2677	316407.1800065	2.2e-221	774.6	Escherichia	proV	GO:0000166,GO:0003674,GO:0004888,GO:0005034,GO:0005215,GO:0005275,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015837,GO:0015838,GO:0016020,GO:0016021,GO:0017076,GO:0022857,GO:0023052,GO:0030554,GO:0031224,GO:0031460,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0038023,GO:0043167,GO:0043168,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060089,GO:0065007,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.32	ko:K02000	ko02010,map02010	M00208			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12		iAF1260.b2677,iB21_1397.B21_02497,iBWG_1329.BWG_2420,iEC042_1314.EC042_2875,iEC55989_1330.EC55989_2945,iECBD_1354.ECBD_1042,iECB_1328.ECB_02533,iECDH1ME8569_1439.ECDH1ME8569_2593,iECD_1391.ECD_02533,iECED1_1282.ECED1_3132,iECIAI1_1343.ECIAI1_2773,iECO103_1326.ECO103_3218,iECO111_1330.ECO111_3401,iECO26_1355.ECO26_3746,iECSE_1348.ECSE_2930,iECW_1372.ECW_m2874,iEKO11_1354.EKO11_1094,iETEC_1333.ETEC_2874,iEcDH1_1363.EcDH1_1006,iEcE24377_1341.EcE24377A_2958,iEcolC_1368.EcolC_1029,iG2583_1286.G2583_3325,iJO1366.b2677,iJR904.b2677,iSBO_1134.SBO_2839,iSbBS512_1146.SbBS512_E3202,iUMNK88_1353.UMNK88_3346,iWFL_1372.ECW_m2874,iY75_1357.Y75_RS13940	Escherichia	1MU86@1224,1RN2R@1236,3XMCF@561,COG4175@1,COG4175@2	NA|NA|NA	P	glycine, betaine
b2678	316407.1800066	1.5e-189	668.7	Escherichia	proW	GO:0003674,GO:0005215,GO:0005275,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0015695,GO:0015696,GO:0015697,GO:0015837,GO:0015838,GO:0015871,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0031460,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K02001	ko02010,map02010	M00208			ko00000,ko00001,ko00002,ko02000	3.A.1.12		iEcSMS35_1347.EcSMS35_2800	Escherichia	1MUM4@1224,1RPQS@1236,3XM5A@561,COG4176@1,COG4176@2	NA|NA|NA	P	glycine betaine
b2679	155864.EDL933_3845	1.2e-193	682.2	Escherichia	proX	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0030288,GO:0030313,GO:0031460,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0050997,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337		ko:K02002	ko02010,map02010	M00208			ko00000,ko00001,ko00002,ko02000	3.A.1.12		iB21_1397.B21_02499,iEC55989_1330.EC55989_2947,iECBD_1354.ECBD_1040,iECB_1328.ECB_02535,iECD_1391.ECD_02535,iECO103_1326.ECO103_3220,iECO111_1330.ECO111_3403,iECO26_1355.ECO26_3748,iECW_1372.ECW_m2876,iEKO11_1354.EKO11_1092,iEcHS_1320.EcHS_A2815,iEcolC_1368.EcolC_1027,iUMNK88_1353.UMNK88_3348,iWFL_1372.ECW_m2876	Escherichia	1MWZU@1224,1RNDF@1236,3XP4T@561,COG2113@1,COG2113@2	NA|NA|NA	E	Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Binds glycine betaine and proline betaine with high affinity
b2681	316407.85675521	2.6e-38	166.4	Escherichia	ygaY												Escherichia	1MVVW@1224,1RMXR@1236,3XNFB@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b2682	316407.85675522	1.4e-130	472.2	Escherichia	ygaZ	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015238,GO:0015318,GO:0015562,GO:0015658,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903785,GO:1903825,GO:1905039										iE2348C_1286.E2348C_2946,iEC042_1314.EC042_2879,iEC55989_1330.EC55989_2949,iECABU_c1320.ECABU_c29480,iECED1_1282.ECED1_3136,iECIAI1_1343.ECIAI1_2777,iECIAI39_1322.ECIAI39_2871,iECO111_1330.ECO111_3405,iECO26_1355.ECO26_3750,iECP_1309.ECP_2647,iECSE_1348.ECSE_2935,iECSF_1327.ECSF_2478,iECSP_1301.ECSP_3629,iECW_1372.ECW_m2878,iECs_1301.ECs3544,iEKO11_1354.EKO11_1090,iETEC_1333.ETEC_2878,iEcE24377_1341.EcE24377A_2965,iG2583_1286.G2583_3329,iLF82_1304.LF82_3135,iNRG857_1313.NRG857_13135,iSFV_1184.SFV_2822,iSSON_1240.SSON_2826,iWFL_1372.ECW_m2878,iZ_1308.Z3983,ic_1306.c3235	Escherichia	1P6U3@1224,1RRMC@1236,3XNS1@561,COG1296@1,COG1296@2	NA|NA|NA	E	L-valine transmembrane transporter activity
b2683	316407.1800068	2.1e-52	211.5	Escherichia	ygaH	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015238,GO:0015318,GO:0015562,GO:0015658,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903785,GO:1903825,GO:1905039										iE2348C_1286.E2348C_2947,iECABU_c1320.ECABU_c29490,iECED1_1282.ECED1_3137,iECH74115_1262.ECH74115_3927,iECP_1309.ECP_2648,iECSF_1327.ECSF_2479,iECSP_1301.ECSP_3630,iECs_1301.ECs3545,iEcE24377_1341.EcE24377A_2966,iG2583_1286.G2583_3330,iLF82_1304.LF82_3128,iNRG857_1313.NRG857_13140,iSDY_1059.SDY_2878,iSFV_1184.SFV_2821,iSF_1195.SF2710,iSFxv_1172.SFxv_2973,iS_1188.S2897,ic_1306.c3236	Escherichia	1N2MP@1224,1S9C1@1236,2C11C@1,32WP6@2,3XPT9@561	NA|NA|NA	S	L-valine transmembrane transporter activity
b2684	155864.EDL933_3850	2.9e-93	347.8	Escherichia	mprA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K15974		M00701			ko00000,ko00002,ko03000				Escherichia	1NWZ4@1224,1RPCJ@1236,3XP69@561,COG1846@1,COG1846@2	NA|NA|NA	K	Negative regulator of the multidrug operon emrAB
b2685	316407.1800070	4.4e-198	697.2	Escherichia	emrA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0009897,GO:0009986,GO:0016020,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098552,GO:0098567		ko:K03543		M00701			ko00000,ko00002,ko02000	8.A.1.1			Escherichia	1MU7I@1224,1RMAD@1236,3XP2J@561,COG1566@1,COG1566@2	NA|NA|NA	V	Multidrug resistance protein
b2686	155864.EDL933_3853	1.1e-284	985.3	Escherichia	emrB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0009636,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03446		M00701			ko00000,ko00002,ko02000	2.A.1.3			Escherichia	1MU1I@1224,1RNTG@1236,3XPHW@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b2687	316407.1800072	2e-94	351.7	Escherichia	luxS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0007154,GO:0007267,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009116,GO:0009119,GO:0009372,GO:0009987,GO:0010699,GO:0016053,GO:0016829,GO:0016846,GO:0017144,GO:0019284,GO:0019752,GO:0023052,GO:0033353,GO:0034641,GO:0042278,GO:0043094,GO:0043102,GO:0043436,GO:0043768,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046128,GO:0046394,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0051704,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657	4.4.1.21	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	M00609	R01291	RC00069,RC01929	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_2877	Escherichia	1MWQF@1224,1RMDZ@1236,3XN36@561,COG1854@1,COG1854@2	NA|NA|NA	F	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
b2688	199310.c3245	3.4e-307	1060.1	Escherichia	gshA	GO:0003674,GO:0003824,GO:0004357,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0010038,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042221,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046685,GO:0046689,GO:0046872,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0070887,GO:0071241,GO:0071243,GO:0071248,GO:0071288,GO:0071704,GO:1901564,GO:1901566,GO:1901576	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_2885	Escherichia	1MW9B@1224,1RPNQ@1236,3XNK6@561,COG2918@1,COG2918@2	NA|NA|NA	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily
b2689	198214.SF2716	4.6e-73	280.4	Gammaproteobacteria													Escherichia	1RHUV@1224,1S69A@1236,COG1238@1,COG1238@2	NA|NA|NA	S	Membrane
b2690	316407.1800081	4.6e-105	387.1	Escherichia	yqaB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008801,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872										iSF_1195.SF2717,iSFxv_1172.SFxv_2981,iS_1188.S2904	Escherichia	1PUMZ@1224,1RNJC@1236,3XP7X@561,COG0637@1,COG0637@2	NA|NA|NA	S	beta-phosphoglucomutase activity
b2696	1005994.GTGU_02525	3.2e-23	113.6	Gammaproteobacteria													Escherichia	1N6PG@1224,1SCB4@1236,COG1551@1,COG1551@2	NA|NA|NA	J	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
b2697	316407.1800083	0.0	1715.3	Escherichia	alaS	GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833	Escherichia	1MU9A@1224,1RMWZ@1236,3XP02@561,COG0013@1,COG0013@2	NA|NA|NA	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
b2698	316407.1800084	2.2e-90	338.2	Escherichia	recX	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496		ko:K03565					ko00000,ko03400				Escherichia	1N6P6@1224,1SCMF@1236,3XMI0@561,COG2137@1,COG2137@2	NA|NA|NA	S	Modulates RecA activity through direct physical interaction. Can inhibit both RecA recombinase and coprotease activities. May have a regulatory role during the SOS response. Inhibits DNA strand exchange in vitro
b2699	155864.EDL933_3863	1.7e-193	681.8	Escherichia	recA	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0006928,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0010212,GO:0031668,GO:0033554,GO:0034641,GO:0040011,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K03553	ko03440,map03440	M00729			ko00000,ko00001,ko00002,ko03400				Escherichia	1MU3C@1224,1RMHP@1236,3XP8Q@561,COG0468@1,COG0468@2	NA|NA|NA	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
b2700	199310.c3254	6.1e-85	320.1	Escherichia	ygaD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016811,GO:0019159	3.5.1.42	ko:K03743	ko00760,map00760		R02322	RC00100	ko00000,ko00001,ko01000				Escherichia	1RH2Y@1224,1S5WH@1236,3XMR0@561,COG1546@1,COG1546@2	NA|NA|NA	S	Belongs to the CinA family
b2701	316407.1800087	1.1e-206	725.7	Escherichia	mltB	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031402,GO:0031420,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0044462,GO:0044464,GO:0046872,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K08305					ko00000,ko01000,ko01011		GH103	iECABU_c1320.ECABU_c29710,iNRG857_1313.NRG857_13215	Escherichia	1MUZ3@1224,1RMQ6@1236,3XMG0@561,COG2951@1,COG2951@2	NA|NA|NA	M	Lytic murein transglycosylase B
b2702	316407.85675525	1.1e-103	382.5	Gammaproteobacteria													Escherichia	1MXS5@1224,1RQTZ@1236,COG3730@1,COG3730@2	NA|NA|NA	G	PTS system glucitol sorbitol-specific
b2703	316407.85675526	1.1e-162	579.3	Gammaproteobacteria													Escherichia	1QJR2@1224,1RQY1@1236,COG3732@1,COG3732@2	NA|NA|NA	G	PTS system glucitol sorbitol-specific
b2704	316407.85675527	4e-65	253.8	Escherichia	srlB	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0051179,GO:0051234,GO:0071702	2.7.1.198	ko:K02781	ko00051,ko02060,map00051,map02060	M00280	R05820	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.4.1		iB21_1397.B21_02519,iEC55989_1330.EC55989_2966,iECBD_1354.ECBD_1021,iECB_1328.ECB_02554,iECD_1391.ECD_02554,iECIAI39_1322.ECIAI39_2890,iECO111_1330.ECO111_3422,iECO26_1355.ECO26_3767,iECSE_1348.ECSE_2952,iECSP_1301.ECSP_3652,iECW_1372.ECW_m2903,iECs_1301.ECs3560,iEKO11_1354.EKO11_1071,iEcE24377_1341.EcE24377A_2988,iEcHS_1320.EcHS_A2840,iEcolC_1368.EcolC_1008,iG2583_1286.G2583_3352,iSSON_1240.SSON_2848,iWFL_1372.ECW_m2903,iZ_1308.Z4011	Escherichia	1RK6V@1224,1S6MU@1236,3XQY8@561,COG3731@1,COG3731@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol sorbitol transport. It can also use D- mannitol
b2705	316407.1800091	4.2e-141	507.3	Escherichia	srlD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0009010,GO:0016491,GO:0016614,GO:0016616,GO:0042802,GO:0055114	1.1.1.140	ko:K00068	ko00051,map00051		R05607	RC00085	ko00000,ko00001,ko01000			iAF1260.b2705,iBWG_1329.BWG_2441,iEC55989_1330.EC55989_2967,iECDH10B_1368.ECDH10B_2873,iECDH1ME8569_1439.ECDH1ME8569_2615,iECIAI1_1343.ECIAI1_2797,iECO111_1330.ECO111_3423,iECO26_1355.ECO26_3768,iECW_1372.ECW_m2904,iEKO11_1354.EKO11_1070,iETEC_1333.ETEC_2896,iEcDH1_1363.EcDH1_0984,iEcE24377_1341.EcE24377A_2989,iJO1366.b2705,iJR904.b2705,iSDY_1059.SDY_2902,iUMNK88_1353.UMNK88_3377,iWFL_1372.ECW_m2904,iY75_1357.Y75_RS14080	Escherichia	1MWSB@1224,1RNVJ@1236,3XQBG@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	sorbitol catabolic process
b2706	316407.1800092	7.6e-61	239.6	Escherichia	gutM	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K02466					ko00000				Escherichia	1RIKE@1224,1S7CD@1236,3XQY2@561,COG4578@1,COG4578@2	NA|NA|NA	K	Glucitol operon activator
b2707	316407.85675528	2.7e-140	504.6	Escherichia	srlR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K02468					ko00000,ko03000				Escherichia	1MUJG@1224,1RNW4@1236,3XQVW@561,COG1349@1,COG1349@2	NA|NA|NA	K	phosphoenolpyruvate-dependent sugar phosphotransferase system
b2708	155864.EDL933_3875	4.3e-175	620.5	Escherichia	gutQ	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0019146,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046400,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.3.1.13	ko:K02467			R01530	RC00541	ko00000,ko01000			iAPECO1_1312.APECO1_3818,iECABU_c1320.ECABU_c29780,iECED1_1282.ECED1_3157,iECOK1_1307.ECOK1_3081,iECS88_1305.ECS88_2971,iUTI89_1310.UTI89_C3070,ic_1306.c3262	Escherichia	1MUXD@1224,1RMT9@1236,3XQB3@561,COG0517@1,COG0517@2,COG0794@1,COG0794@2	NA|NA|NA	F	It is also able of sustaining the biosynthetic pathway of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs)
b2709	316407.85675530	2.3e-284	984.2	Escherichia	norR	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005506,GO:0005515,GO:0006355,GO:0008150,GO:0008198,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0035326,GO:0042802,GO:0043167,GO:0043169,GO:0043254,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0045893,GO:0045935,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070026,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K12266	ko05132,map05132				ko00000,ko00001,ko03000				Escherichia	1QTT3@1224,1T1G7@1236,3XMM3@561,COG3604@1,COG3604@2	NA|NA|NA	K	Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54
b2710	316407.85675531	8e-287	992.3	Escherichia	norV	GO:0000166,GO:0000302,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009987,GO:0010035,GO:0010181,GO:0016043,GO:0016491,GO:0016661,GO:0017144,GO:0022607,GO:0022900,GO:0032553,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042493,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044464,GO:0046209,GO:0046210,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0065007,GO:0065008,GO:0071731,GO:0071840,GO:0072593,GO:0097159,GO:0097366,GO:0097367,GO:1901265,GO:1901363,GO:1901698,GO:1901700,GO:2001057		ko:K12264	ko05132,map05132				ko00000,ko00001			iE2348C_1286.E2348C_2967,iECED1_1282.ECED1_3159	Escherichia	1N731@1224,1SC8Q@1236,3XMY5@561,COG0426@1,COG0426@2,COG1773@1,COG1773@2	NA|NA|NA	C	uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center
b2711	316407.85675532	8.2e-210	736.1	Escherichia	norW	GO:0000166,GO:0000302,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0015044,GO:0016491,GO:0016730,GO:0016731,GO:0017144,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042493,GO:0042737,GO:0043167,GO:0043168,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044464,GO:0046209,GO:0046210,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071241,GO:0071731,GO:0071732,GO:0072593,GO:0097159,GO:0097366,GO:1901265,GO:1901363,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:2001057		ko:K12265	ko05132,map05132				ko00000,ko00001,ko01000			iEcHS_1320.EcHS_A2847	Escherichia	1NR3M@1224,1RQ07@1236,3XPFH@561,COG0446@1,COG0446@2	NA|NA|NA	C	One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase
b2712	316407.85675533	0.0	1466.8	Escherichia	hypF	GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016740,GO:0016741,GO:0016743,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0046944,GO:0051604,GO:0071704,GO:1901564		ko:K04656					ko00000				Escherichia	1MVP8@1224,1RP08@1236,3XM8R@561,COG0068@1,COG0068@2	NA|NA|NA	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
b2713	155864.EDL933_3881	5.5e-100	370.2	Escherichia	hydN	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044464,GO:0055114		ko:K05796					ko00000				Escherichia	1PENN@1224,1RS57@1236,3XNQ6@561,COG1142@1,COG1142@2	NA|NA|NA	C	electron transport from formate to hydrogen
b2714	316407.85675535	1.4e-184	652.1	Escherichia	ascG	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03487					ko00000,ko03000				Escherichia	1N4ND@1224,1RNR5@1236,3XMZV@561,COG1609@1,COG1609@2	NA|NA|NA	K	Repressor of the asc operon. The cryptic operon is activated by the insertion of IS186 into the ascG gene
b2715	316407.85675536	1.2e-258	898.7	Escherichia	ascF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015766,GO:0015771,GO:0015772,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090589		ko:K02752,ko:K02753	ko00010,ko02060,map00010,map02060	M00272	R04394,R05132	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.2.3		iAPECO1_1312.APECO1_3811,iECIAI39_1322.ECIAI39_2901,iECOK1_1307.ECOK1_3087,iECS88_1305.ECS88_2978,iUMN146_1321.UM146_03015,iUTI89_1310.UTI89_C3077	Escherichia	1MXEG@1224,1RNEG@1236,3XP49@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in arbutin, cellobiose, and salicin transport
b2716	316407.85675537	3.2e-288	996.9	Escherichia	ascB	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0008150,GO:0008152,GO:0008422,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0071704,GO:1901135,GO:1901575,GO:1901657,GO:2000891,GO:2000892	3.2.1.86	ko:K01223	ko00010,ko00500,map00010,map00500		R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000		GT1		Escherichia	1MWG6@1224,1RMM2@1236,3XNCY@561,COG2723@1,COG2723@2	NA|NA|NA	G	Catalyzes the hydrolysis of phosphorylated beta- glucosides into glucose-6-phosphate (G-6-P) and aglycone. It has a high affinity for phosphorylated aromatic beta-glucosides (p- nitrophenyl-beta-glucoside, phenyl beta-glucoside, arbutin and phosphorylated salicin), and a low affinity for phosphorylated beta-methyl-glucoside
b2717	155864.EDL933_3886	1.5e-85	322.0	Escherichia	hycI	GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.23.51	ko:K08315					ko00000,ko01000,ko01002				Escherichia	1R3V7@1224,1S0IE@1236,3XP3A@561,COG0680@1,COG0680@2	NA|NA|NA	C	Protease involved in the C-terminal processing of HycE, the large subunit of hydrogenase 3
b2718	155864.EDL933_3887	6.4e-72	276.6	Escherichia	hycH			ko:K15834					ko00000				Escherichia	1RACI@1224,1T11Y@1236,2DBX5@1,2ZBMB@2,3XRMP@561	NA|NA|NA	E	Seems to be required for the conversion of a precursor form of the large subunit of hydrogenlyase (HycE) into a mature form
b2719	316407.85675540	2.3e-147	528.1	Escherichia	hycG			ko:K15832					ko00000			iEC55989_1330.EC55989_2985,iECNA114_1301.ECNA114_2753,iECSF_1327.ECSF_2512	Escherichia	1QUBE@1224,1RNUG@1236,3XMV7@561,COG3260@1,COG3260@2	NA|NA|NA	C	Formate hydrogenlyase
b2720	316407.85675541	4.6e-86	323.9	Escherichia	hycF			ko:K15831					ko00000			iAPECO1_1312.APECO1_3805,iECABU_c1320.ECABU_c29910,iECED1_1282.ECED1_3171,iECOK1_1307.ECOK1_3094,iUMN146_1321.UM146_02980,iUTI89_1310.UTI89_C3083,ic_1306.c3280	Escherichia	1R9YT@1224,1RQB1@1236,3XMEE@561,COG1143@1,COG1143@2	NA|NA|NA	C	electron transfer protein for hydrogenase
b2721	316407.85675542	0.0	1177.5	Escherichia	hycE	GO:0003674,GO:0005488,GO:0016151,GO:0043167,GO:0043169,GO:0046872,GO:0046914		ko:K15830					ko00000			iECED1_1282.ECED1_3172	Escherichia	1QUBF@1224,1RSJ4@1236,3XNB6@561,COG3261@1,COG3261@2,COG3262@1,COG3262@2	NA|NA|NA	C	nickel cation binding
b2722	316407.85675543	4.7e-163	580.5	Escherichia	hycD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K15829					ko00000			iSFV_1184.SFV_2781	Escherichia	1MXV5@1224,1RPCY@1236,3XNSF@561,COG0650@1,COG0650@2	NA|NA|NA	C	oxidoreductase activity
b2723	316407.85675544	0.0	1157.9	Escherichia	hycC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K15828					ko00000			iB21_1397.B21_02538,iECBD_1354.ECBD_1002,iECB_1328.ECB_02573,iECD_1391.ECD_02573,iECED1_1282.ECED1_3174,iECO111_1330.ECO111_3443,iECO26_1355.ECO26_3788,iECP_1309.ECP_2686,iEcHS_1320.EcHS_A2859,iLF82_1304.LF82_1065,iNRG857_1313.NRG857_13330	Escherichia	1MXRW@1224,1RM9Q@1236,3XMXV@561,COG0651@1,COG0651@2	NA|NA|NA	CP	Formate hydrogenlyase, subunit
b2724	198214.SF2741	2.6e-109	401.4	Gammaproteobacteria													Escherichia	1MUHW@1224,1RQWU@1236,COG1142@1,COG1142@2	NA|NA|NA	C	Formate hydrogenlyase
b2725	155864.EDL933_3894	1.8e-83	315.1	Escherichia	hycA			ko:K15833					ko00000				Escherichia	1RD07@1224,1S49S@1236,2C05Z@1,305VH@2,3XNMX@561	NA|NA|NA	K	Regulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence
b2726	155864.EDL933_3896	5.1e-62	243.4	Escherichia	hypA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009898,GO:0010467,GO:0016020,GO:0016151,GO:0019538,GO:0019897,GO:0019898,GO:0031234,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1901564		ko:K04651					ko00000,ko03110				Escherichia	1MZJH@1224,1S5WG@1236,3XPNU@561,COG0375@1,COG0375@2	NA|NA|NA	S	Probably plays a role in a hydrogenase nickel cofactor insertion step
b2727	199310.c3287	6.6e-167	593.2	Escherichia	hypB	GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010467,GO:0016151,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:1901564		ko:K04652					ko00000,ko03110				Escherichia	1MVBD@1224,1RN9Y@1236,3XNGB@561,COG0378@1,COG0378@2	NA|NA|NA	KO	Required for the maturation of the three NiFe hydrogenases. Exhibits a low intrinsic GTPase activity. The GTP hydrolysis catalyzed by HypB is an integral process in the incorporation of nickel into hydrogenases
b2728	155864.EDL933_3898	6.8e-46	189.5	Escherichia	hypC	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:1901564,GO:1902670		ko:K04653					ko00000				Escherichia	1RGXH@1224,1S96I@1236,3XPUT@561,COG0298@1,COG0298@2	NA|NA|NA	O	Is required for the formation of all three hydrogenase isoenzymes. May bind to the precursor form of the large subunit of dehydrogenases to keep them in a conformation accessible for metal incorporation
b2729	316407.85675550	5.4e-222	776.5	Escherichia	hypD	GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564		ko:K04654					ko00000				Escherichia	1MU1F@1224,1RRTQ@1236,3XN0A@561,COG0409@1,COG0409@2	NA|NA|NA	O	Belongs to the HypD family
b2730	481805.EcolC_0982	1.9e-186	658.3	Escherichia	hypE	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0018193,GO:0018198,GO:0018249,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046892,GO:0051604,GO:0071704,GO:1901564		ko:K04655					ko00000				Escherichia	1MVCC@1224,1RQBE@1236,3XMMN@561,COG0309@1,COG0309@2	NA|NA|NA	O	formation protein hypE
b2731	316407.85675552	0.0	1355.1	Escherichia	fhlA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141		ko:K15836					ko00000,ko03000				Escherichia	1QTT3@1224,1T1G7@1236,3XN8S@561,COG3604@1,COG3604@2	NA|NA|NA	KT	Formate hydrogen-lyase transcriptional activator
b2732	316407.85675553	7.2e-64	249.6	Escherichia	ygbA												Escherichia	1N8FZ@1224,1S42H@1236,2E4R1@1,32ZJK@2,3XPTA@561	NA|NA|NA	S	Nitrous oxide-stimulated promoter
b2733	316407.85675554	0.0	1663.7	Escherichia	mutS	GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008301,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0030983,GO:0031323,GO:0032136,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391		ko:K03555	ko03430,map03430				ko00000,ko00001,ko03400			iECW_1372.ECW_m2935,iWFL_1372.ECW_m2935	Escherichia	1MUGX@1224,1RNW3@1236,3XMSY@561,COG0249@1,COG0249@2	NA|NA|NA	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
b2734	316407.85675555	3.8e-127	460.7	Escherichia	pphB	GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	3.1.3.16	ko:K07314					ko00000,ko01000				Escherichia	1RAJ3@1224,1S3E3@1236,3XPTG@561,COG0639@1,COG0639@2	NA|NA|NA	T	phosphatase 2
b2735	316407.85675556	1.9e-133	481.9	Escherichia	ygbI	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1MUJG@1224,1RQW3@1236,3XP4G@561,COG1349@1,COG1349@2	NA|NA|NA	K	Transcriptional regulator
b2736	316407.85675557	2.8e-160	571.2	Escherichia	ygbJ		1.1.1.411	ko:K08319					ko00000,ko01000				Escherichia	1MUD0@1224,1RQXA@1236,3XPGH@561,COG2084@1,COG2084@2	NA|NA|NA	I	Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD( ) or NADP( ) as cosubstrate, with a preference for NAD( )
b2737	316407.85675558	6e-216	756.5	Escherichia	ygbK		2.7.1.217	ko:K21948			R11706,R11707		ko00000,ko01000				Escherichia	1MW4G@1224,1RN8I@1236,3XN2W@561,COG3395@1,COG3395@2	NA|NA|NA	S	kinase activity
b2738	316407.85675559	2.1e-117	428.3	Escherichia	ygbL	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019321,GO:0019323,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0071704,GO:1901575	4.1.1.104	ko:K22130					ko00000,ko01000			iECED1_1282.ECED1_3191	Escherichia	1MW7B@1224,1RS8X@1236,3XPD2@561,COG0235@1,COG0235@2	NA|NA|NA	G	Belongs to the aldolase class II family. AraD FucA subfamily
b2739	316407.85675560	3.4e-151	540.8	Escherichia	ygbM		5.3.1.35	ko:K22131					ko00000,ko01000				Escherichia	1MV53@1224,1RQF9@1236,3XMPT@561,COG3622@1,COG3622@2	NA|NA|NA	G	isomerase activity
b2740	316407.85675561	1.2e-234	818.9	Escherichia	ygbN	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03299					ko00000,ko02000	2.A.8			Escherichia	1MUFG@1224,1RNGE@1236,3XNU2@561,COG2610@1,COG2610@2	NA|NA|NA	EG	gluconate transmembrane transporter activity
b2741	511145.b2741	3.2e-178	630.9	Gammaproteobacteria													Escherichia	1MUDI@1224,1RN8V@1236,COG0568@1,COG0568@2	NA|NA|NA	K	RNA polymerase sigma
b2742	198214.SF2765	3.6e-173	614.4	Gammaproteobacteria													Escherichia	1RD24@1224,1RR11@1236,COG1388@1,COG1388@2,COG4942@1,COG4942@2	NA|NA|NA	DM	COG0739 Membrane proteins related to metalloendopeptidases
b2743	155864.EDL933_3913	2.7e-114	417.9	Escherichia	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573					ko00000,ko01000				Escherichia	1MXQC@1224,1RMHZ@1236,3XPAE@561,COG2518@1,COG2518@2	NA|NA|NA	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
b2744	155864.EDL933_3914	2.2e-134	485.0	Escherichia	surE	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000			iSFxv_1172.SFxv_3035	Escherichia	1MVHE@1224,1RN36@1236,3XMK0@561,COG0496@1,COG0496@2	NA|NA|NA	F	Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs
b2745	316407.85675566	1.1e-200	705.7	Escherichia	truD	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176					ko00000,ko01000,ko03016				Escherichia	1MXHD@1224,1RPRF@1236,3XMIA@561,COG0585@1,COG0585@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs
b2746	1440052.EAKF1_ch3247	2.4e-86	324.7	Escherichia	ispF	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008270,GO:0008685,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016849,GO:0030145,GO:0042180,GO:0042181,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000				Escherichia	1MVHA@1224,1S3RQ@1236,3XMDM@561,COG0245@1,COG0245@2	NA|NA|NA	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)
b2747	316407.85675568	1.6e-134	485.3	Escherichia	ispD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016772,GO:0016779,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050518,GO:0070567	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000			iAF1260.b2747,iBWG_1329.BWG_2483,iEC55989_1330.EC55989_3019,iECDH10B_1368.ECDH10B_2915,iECDH1ME8569_1439.ECDH1ME8569_2657,iECIAI1_1343.ECIAI1_2848,iECO103_1326.ECO103_3289,iECO111_1330.ECO111_3471,iECO26_1355.ECO26_3816,iECSE_1348.ECSE_2999,iECW_1372.ECW_m2953,iEKO11_1354.EKO11_1022,iEcDH1_1363.EcDH1_0941,iEcE24377_1341.EcE24377A_3048,iEcHS_1320.EcHS_A2885,iEcolC_1368.EcolC_0965,iJO1366.b2747,iJR904.b2747,iSBO_1134.SBO_2773,iSDY_1059.SDY_2946,iSSON_1240.SSON_2895,iSbBS512_1146.SbBS512_E3127,iUMNK88_1353.UMNK88_3422,iWFL_1372.ECW_m2953,iY75_1357.Y75_RS14300	Escherichia	1MY3B@1224,1S21S@1236,3XMF5@561,COG1211@1,COG1211@2	NA|NA|NA	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)
b2748	155864.EDL933_3918	2.3e-50	204.5	Escherichia	ftsB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301		ko:K05589					ko00000,ko03036				Escherichia	1N7AA@1224,1SD8H@1236,3XPSF@561,COG2919@1,COG2919@2	NA|NA|NA	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
b2749	316407.85675570	9.9e-52	209.1	Escherichia	ygbE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MZA3@1224,1S97Z@1236,2C1QX@1,32TB7@2,3XPZ4@561	NA|NA|NA	S	Protein of unknown function (DUF3561)
b2750	155864.EDL933_3921	1.3e-110	405.6	Escherichia	cysC	GO:0003674,GO:0003824,GO:0004020,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0042802,GO:0044237	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000			iAF1260.b2750,iB21_1397.B21_02565,iBWG_1329.BWG_2486,iEC042_1314.EC042_2944,iEC55989_1330.EC55989_3023,iECBD_1354.ECBD_0974,iECB_1328.ECB_02600,iECDH10B_1368.ECDH10B_2918,iECDH1ME8569_1439.ECDH1ME8569_2660,iECD_1391.ECD_02600,iECH74115_1262.ECH74115_4002,iECIAI1_1343.ECIAI1_2852,iECO111_1330.ECO111_3474,iECO26_1355.ECO26_3819,iECSE_1348.ECSE_3002,iECSP_1301.ECSP_3698,iECUMN_1333.ECUMN_3074,iECW_1372.ECW_m2956,iECs_1301.ECs3604,iEKO11_1354.EKO11_1019,iEcDH1_1363.EcDH1_0938,iEcE24377_1341.EcE24377A_3051,iEcHS_1320.EcHS_A2888,iEcSMS35_1347.EcSMS35_2876,iG2583_1286.G2583_3398,iJO1366.b2750,iJR904.b2750,iSBO_1134.SBO_2770,iSDY_1059.SDY_2949,iSFV_1184.SFV_2748,iSSON_1240.SSON_2898,iUMNK88_1353.UMNK88_3426,iWFL_1372.ECW_m2956,iY75_1357.Y75_RS14315,iZ_1308.Z4058	Escherichia	1MX0D@1224,1RNWT@1236,3XPBT@561,COG0529@1,COG0529@2	NA|NA|NA	F	Catalyzes the synthesis of activated sulfate
b2751	316407.85675572	1.6e-271	941.4	Escherichia	cysN	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0004779,GO:0004781,GO:0005488,GO:0005525,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0070566,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.7.4	ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_3293	Escherichia	1MUD9@1224,1RME4@1236,3XMW1@561,COG2895@1,COG2895@2	NA|NA|NA	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily
b2752	316407.85675573	6.2e-176	623.2	Escherichia	cysD	GO:0003674,GO:0003824,GO:0004779,GO:0004781,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0044237,GO:0050896,GO:0070566	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000			iUMNK88_1353.UMNK88_3428,iYL1228.KPN_03114	Escherichia	1MUCZ@1224,1RNAD@1236,3XNQR@561,COG0175@1,COG0175@2	NA|NA|NA	H	sulfate adenylyltransferase), subunit 2
b2753	316407.85675574	8.6e-198	696.0	Escherichia	iap	GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564		ko:K09612					ko00000,ko01000,ko01002				Escherichia	1P2WI@1224,1RRBM@1236,3XNQ4@561,COG2234@1,COG2234@2	NA|NA|NA	S	This protein, presumably an aminopeptidase, mediates the conversion of E.coli alkaline phosphatase isozyme 1, to isozymes 2 and 3 by removing, one by one, the two N-terminal arginine residues
b2754	316407.85675575	7.1e-46	189.5	Escherichia	ygbF	GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0034641,GO:0043170,GO:0043570,GO:0043571,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:1901360		ko:K09951					ko00000,ko02048				Escherichia	1N05B@1224,1S6XV@1236,3XPVM@561,COG0847@1,COG0847@2	NA|NA|NA	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The Cas1-Cas2 complex is involved in CRISPR adaptation, the first stage of CRISPR immunity, being required for the addition removal of CRISPR spacers at the leader end of the CRISPR locus. The Cas1-Cas2 complex introduces staggered nicks into both strands of the CRISPR array near the leader repeat and joins the 5'-ends of the repeat strands with the 3'-ends of the new spacer sequence. Spacer DNA integration requires supercoiled target DNA and 3'-OH ends on the inserted (spacer) DNA and probably initiates with a nucleophilic attack of the C 3'-OH end of the protospacer on the minus strand of the first repeat sequence. Expression of Cas1-Cas2 in a strain lacking both genes permits spacer acquisition. Cas2 not seen to bind DNA alone
b2755	316407.85675576	3e-170	604.4	Escherichia	ygbT	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0008821,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0016888,GO:0016889,GO:0016893,GO:0016894,GO:0017108,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043570,GO:0043571,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048256,GO:0050896,GO:0051276,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360		ko:K15342					ko00000,ko02048,ko03400				Escherichia	1MUXH@1224,1RP48@1236,3XQ5R@561,COG1518@1,COG1518@2	NA|NA|NA	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
b2756	316407.85675577	1e-110	406.0	Escherichia	casE	GO:0002252,GO:0002376,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0098542,GO:0140098,GO:1901360,GO:1901363		ko:K19126					ko00000,ko02048				Escherichia	1RGHV@1224,1S1ZF@1236,2DMIY@1,32RWI@2,3XQZ8@561	NA|NA|NA	J	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA)
b2757	316407.85675578	3.2e-129	467.6	Escherichia	casD	GO:0002252,GO:0002376,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006950,GO:0006952,GO:0008150,GO:0009605,GO:0009607,GO:0009615,GO:0043207,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0071667,GO:0097159,GO:0098542,GO:1901363		ko:K19125					ko00000,ko02048				Escherichia	1R36G@1224,1T63W@1236,2DBXF@1,2ZBPB@2,3XQF0@561	NA|NA|NA	J	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA)
b2758	316407.85675579	6e-202	709.9	Escherichia	casC	GO:0002252,GO:0002376,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006950,GO:0006952,GO:0008150,GO:0009605,GO:0009607,GO:0009615,GO:0043207,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0071667,GO:0097159,GO:0098542,GO:1901363		ko:K19124					ko00000,ko02048				Escherichia	1MVNH@1224,1RMBZ@1236,3XQ9T@561,COG1857@1,COG1857@2	NA|NA|NA	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA)
b2759	316407.85675580	2.2e-87	328.2	Escherichia	casB	GO:0002252,GO:0002376,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006950,GO:0006952,GO:0008150,GO:0009605,GO:0009607,GO:0009615,GO:0043207,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0097159,GO:0098542,GO:1901363		ko:K19046					ko00000,ko02048				Escherichia	1N1SB@1224,1SCET@1236,2D8X9@1,32TS5@2,3XR00@561	NA|NA|NA	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA)
b2760	316407.85675581	1.7e-300	1037.7	Escherichia	casA	GO:0002252,GO:0002376,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0005488,GO:0006950,GO:0006952,GO:0008150,GO:0008270,GO:0009605,GO:0009607,GO:0009615,GO:0043167,GO:0043169,GO:0043207,GO:0046872,GO:0046914,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0097159,GO:0098542,GO:1901363		ko:K19123					ko00000,ko02048				Escherichia	1NBNZ@1224,1RQGK@1236,2Z880@2,3XQ7P@561,arCOG04928@1	NA|NA|NA	S	defense response to virus
b2761	316407.85675582	0.0	1830.8	Escherichia	ygcB	GO:0000014,GO:0000287,GO:0000737,GO:0000738,GO:0002252,GO:0002376,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0008296,GO:0008408,GO:0009056,GO:0009057,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017111,GO:0019439,GO:0033677,GO:0033680,GO:0034641,GO:0034655,GO:0042623,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0046872,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0070035,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0097098,GO:0097159,GO:0097617,GO:0098542,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575		ko:K07012					ko00000,ko01000,ko02048				Escherichia	1MX99@1224,1RMM0@1236,3XQCA@561,COG1203@1,COG1203@2	NA|NA|NA	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity
b2762	316407.85675583	1.3e-139	502.3	Escherichia	cysH	GO:0000103,GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019379,GO:0019419,GO:0044237,GO:0044424,GO:0044464,GO:0055114	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_3025,iECABU_c1320.ECABU_c30290,iECNA114_1301.ECNA114_2793,iECO103_1326.ECO103_3306,iECP_1309.ECP_2736,iECSF_1327.ECSF_2551,iETEC_1333.ETEC_2955,iLF82_1304.LF82_0415,iNRG857_1313.NRG857_13505,iSDY_1059.SDY_2964,ic_1306.c3321	Escherichia	1MXUR@1224,1RNC5@1236,3XMR6@561,COG0175@1,COG0175@2	NA|NA|NA	EH	Reduction of activated sulfate into sulfite
b2763	316407.85675584	0.0	1172.1	Escherichia	cysI	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016667,GO:0016673,GO:0019419,GO:0020037,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0046906,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0097159,GO:1901363	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_3037,iECH74115_1262.ECH74115_4017,iECIAI1_1343.ECIAI1_2867,iECNA114_1301.ECNA114_2794,iECO103_1326.ECO103_3307,iECSE_1348.ECSE_3019,iECSF_1327.ECSF_2552,iECSP_1301.ECSP_3712,iECUMN_1333.ECUMN_3091,iECW_1372.ECW_m2971,iECs_1301.ECs3618,iEKO11_1354.EKO11_1005,iEcE24377_1341.EcE24377A_3065,iSFV_1184.SFV_2742,iSbBS512_1146.SbBS512_E3112,iWFL_1372.ECW_m2971,iZ_1308.Z4073	Escherichia	1MVVB@1224,1RMFH@1236,3XMSN@561,COG0155@1,COG0155@2	NA|NA|NA	H	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate
b2764	316407.85675585	0.0	1184.1	Escherichia	cysJ	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009337,GO:0010181,GO:0016491,GO:0016645,GO:0016646,GO:0032553,GO:0032991,GO:0036094,GO:0042602,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0055114,GO:0070401,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.8.1.2	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000			iECO26_1355.ECO26_3835,iECSE_1348.ECSE_3020,iECW_1372.ECW_m2972,iEKO11_1354.EKO11_1004,iEcE24377_1341.EcE24377A_3066,iEcolC_1368.EcolC_0948,iWFL_1372.ECW_m2972	Escherichia	1QUAH@1224,1T1RJ@1236,3XM2T@561,COG0369@1,COG0369@2	NA|NA|NA	E	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
b2765	316407.85675586	7.7e-69	266.2	Escherichia	queD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0070497,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016			iECIAI39_1322.ECIAI39_2947,iUTI89_1310.UTI89_C3129,ic_1306.c3324	Escherichia	1RI4P@1224,1S3T6@1236,3XPM2@561,COG0720@1,COG0720@2	NA|NA|NA	F	Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde
b2766	316407.85675587	5.9e-249	866.3	Escherichia	ygcN			ko:K00313					ko00000,ko01000				Escherichia	1MVU6@1224,1RNY5@1236,3XMS4@561,COG0644@1,COG0644@2	NA|NA|NA	C	electron transfer flavoprotein-quinone oxidoreductase YgcN
b2767	316407.85675588	5e-46	189.9	Escherichia	ygcO	GO:0008150,GO:0009292,GO:0009294,GO:0009987,GO:0044764,GO:0051704											Escherichia	1NVQF@1224,1SRQW@1236,3XR47@561,COG2440@1,COG2440@2	NA|NA|NA	C	Could be a 3Fe-4S cluster-containing protein
b2768	316407.85675589	2.2e-102	378.3	Escherichia	ygcP												Escherichia	1R7RN@1224,1RQJJ@1236,3XM87@561,COG1954@1,COG1954@2	NA|NA|NA	K	response to biotic stimulus
b2769	316407.85675590	7.2e-158	563.1	Escherichia	ygcQ												Escherichia	1N6KU@1224,1SBCS@1236,3XPFS@561,COG2025@1,COG2025@2	NA|NA|NA	C	Electron transfer flavoprotein
b2770	316407.85675591	6.5e-142	510.0	Escherichia	ygcR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114											Escherichia	1R48G@1224,1S1J9@1236,3XP0M@561,COG2086@1,COG2086@2	NA|NA|NA	C	Electron transfer flavoprotein
b2771	316407.85675592	5.8e-247	859.8	Escherichia	ygcS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1NS3F@1224,1RQRF@1236,3XQV4@561,COG0477@1,COG0477@2	NA|NA|NA	P	transmembrane transporter activity
b4463	316407.85675593	9.6e-288	995.3	Escherichia	ygcU												Escherichia	1MXTV@1224,1RRN8@1236,3XM2I@561,COG0277@1,COG0277@2	NA|NA|NA	C	flavin adenine dinucleotide binding
b2774	316407.85675594	3.6e-148	530.8	Escherichia	ygcW	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1MWB6@1224,1RSA7@1236,3XM5S@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	Oxidoreductase
b2775	316407.1805578	1.5e-236	825.1	Escherichia	yqcE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1QWC7@1224,1T2TH@1236,3XNNX@561,COG2223@1,COG2223@2	NA|NA|NA	P	transmembrane transport
b2776	316407.85675595	4.7e-298	1029.6	Escherichia	ygcE												Escherichia	1MW4A@1224,1RR7X@1236,3XPE0@561,COG1070@1,COG1070@2	NA|NA|NA	G	Sugar kinase
b2777	1440052.EAKF1_ch3234	1.9e-129	468.4	Escherichia	queE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100		R10002	RC02989	ko00000,ko00001,ko01000,ko03016				Escherichia	1MUJ2@1224,1RNQZ@1236,3XMSU@561,COG0602@1,COG0602@2	NA|NA|NA	F	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
b2778	316407.85675597	8.7e-127	459.9	Escherichia	ygcG			ko:K06872					ko00000				Escherichia	1PB41@1224,1S9CT@1236,3XMZX@561,COG1512@1,COG1512@2	NA|NA|NA	S	TPM domain
b2779	1440052.EAKF1_ch3230	1.1e-237	828.9	Escherichia	eno	GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147				Escherichia	1MU1N@1224,1RNQA@1236,3XNNK@561,COG0148@1,COG0148@2	NA|NA|NA	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
b2780	155864.EDL933_3958	0.0	1094.3	Escherichia	pyrG	GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_3323	Escherichia	1MUIT@1224,1RM92@1236,3XMET@561,COG0504@1,COG0504@2	NA|NA|NA	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
b2781	155864.EDL933_3959	8.4e-145	519.6	Escherichia	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.9	ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100		R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000			iAF1260.b2781,iBWG_1329.BWG_2516,iE2348C_1286.E2348C_3048,iEC55989_1330.EC55989_3056,iECDH10B_1368.ECDH10B_2948,iECDH1ME8569_1439.ECDH1ME8569_2691,iECH74115_1262.ECH74115_4041,iECIAI1_1343.ECIAI1_2889,iECO103_1326.ECO103_3324,iECO111_1330.ECO111_3505,iECO26_1355.ECO26_3851,iECOK1_1307.ECOK1_3155,iECP_1309.ECP_2762,iECSE_1348.ECSE_3039,iECSP_1301.ECSP_3733,iECW_1372.ECW_m2990,iECs_1301.ECs3641,iEKO11_1354.EKO11_0987,iEcDH1_1363.EcDH1_0907,iEcE24377_1341.EcE24377A_3085,iEcHS_1320.EcHS_A2925,iEcolC_1368.EcolC_0931,iG2583_1286.G2583_3433,iJO1366.b2781,iJR904.b2781,iSBO_1134.SBO_2662,iSSON_1240.SSON_2938,iSbBS512_1146.SbBS512_E3092,iUMN146_1321.UM146_02665,iUMNK88_1353.UMNK88_3464,iUTI89_1310.UTI89_C3150,iWFL_1372.ECW_m2990,iY75_1357.Y75_RS14470,iZ_1308.Z4096	Escherichia	1MVKM@1224,1RNVU@1236,3XNQT@561,COG1694@1,COG3956@2	NA|NA|NA	F	mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA
b2782	155864.EDL933_3960	6.6e-59	233.0	Gammaproteobacteria													Escherichia	1MZJ8@1224,1S5J7@1236,COG2337@1,COG2337@2	NA|NA|NA	T	Transcriptional modulator of MazE toxin, MazF
b2783	155864.EDL933_3961	2.3e-40	171.0	Gammaproteobacteria													Escherichia	1N9Z6@1224,1SDVP@1236,COG2336@1,COG2336@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the MazF endoribonuclease toxin and neutralizes its endoribonuclease activity. Is considered to be an 'addiction' molecule as the cell dies in its absence. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. This effect can be rescued by expression of MazE, but after 6 hours in rich medium the overexpression of MazF leads to programmed cell death. Cell growth and viability are not affected when MazF and MazE are coexpressed. Both MazE and MazE-MazF bind to the promoter region of the mazE- mazF operon to inhibit their own transcription. There are 3 operators to which MazE binds. MazE has higher affinity for promoter DNA in the presence of MazF
b2784	155864.EDL933_3962	0.0	1500.3	Escherichia	relA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.7.6.5	ko:K00951	ko00230,map00230		R00429	RC00002,RC00078	ko00000,ko00001,ko01000			iSFV_1184.SFV_2673	Escherichia	1MU44@1224,1RN3H@1236,3XP61@561,COG0317@1,COG0317@2	NA|NA|NA	F	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
b2785	316407.85675604	7.9e-249	865.9	Escherichia	rlmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070041,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.190	ko:K03215					ko00000,ko01000,ko03009				Escherichia	1MV3A@1224,1RN1D@1236,3XNZV@561,COG2265@1,COG2265@2	NA|NA|NA	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA
b2786	155864.EDL933_3964	0.0	1786.2	Escherichia	barA	GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700	2.7.13.3	ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1NRP8@1224,1SKTW@1236,3XMAV@561,COG0642@1,COG2205@2,COG3437@1,COG3437@2,COG3850@1,COG3850@2,COG4999@1,COG4999@2	NA|NA|NA	T	PhoQ Sensor
b2787	155864.EDL933_3965	3.3e-266	923.7	Escherichia	gudD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008872,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0071704,GO:1901575	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100		R02752,R08056	RC00543	ko00000,ko00001,ko01000			iECO26_1355.ECO26_3857	Escherichia	1NAKW@1224,1RNE2@1236,3XPFN@561,COG4948@1,COG4948@2	NA|NA|NA	M	Catalyzes the dehydration of glucarate to 5-keto-4- deoxy-D-glucarate (5-kdGluc). Also acts on L-idarate
b2788	316407.85675607	2.2e-270	937.6	Escherichia	gudX	GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0044237,GO:0044248		ko:K13918					ko00000			iECIAI39_1322.ECIAI39_3210	Escherichia	1NAKW@1224,1RN9M@1236,3XMB0@561,COG4948@1,COG4948@2	NA|NA|NA	M	Does not seem to have an in-vivo activity on glucarate or idarate. Its real substrate is
b2789	316407.85675608	5.3e-256	889.8	Escherichia	gudP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K03535					ko00000,ko02000	2.A.1.14.1		iSSON_1240.SSON_2946	Escherichia	1MVPS@1224,1RNMV@1236,3XP9P@561,COG2271@1,COG2271@2	NA|NA|NA	P	glucarate transporter
b2790	155864.EDL933_3971	2.4e-80	304.7	Escherichia	yqcA	GO:0000166,GO:0003674,GO:0005488,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0097159,GO:0097367,GO:1901265,GO:1901363											Escherichia	1N27T@1224,1S906@1236,3XPFI@561,COG0716@1,COG0716@2	NA|NA|NA	C	FMN binding
b2791	198214.SF2804	5e-150	537.0	Gammaproteobacteria													Escherichia	1N8GW@1224,1RMZ7@1236,COG0564@1,COG0564@2	NA|NA|NA	J	Pseudouridine synthase
b2792	316407.85675611	2.7e-57	227.6	Escherichia	yqcC	GO:0008150,GO:0009987,GO:0042710,GO:0044010,GO:0044764,GO:0051704											Escherichia	1N7AG@1224,1SCXJ@1236,3XPR2@561,COG3098@1,COG3098@2	NA|NA|NA	S	single-species biofilm formation
b2793	199310.c3359	7.9e-102	376.3	Escherichia	syd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0043254,GO:0044087,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0065007,GO:0071944,GO:0098552,GO:0098562		ko:K15723					ko00000				Escherichia	1RAB3@1224,1S2N3@1236,28Q4G@1,2ZCMR@2,3XMHR@561	NA|NA|NA	S	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function
b2794	316407.85675613	4.1e-166	590.5	Escherichia	queF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016651,GO:0016657,GO:0018130,GO:0019438,GO:0033739,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.7.1.13	ko:K06879	ko00790,ko01100,map00790,map01100		R07605	RC01875	ko00000,ko00001,ko01000,ko03016			iSFV_1184.SFV_2663,iSF_1195.SF2807,iS_1188.S3002	Escherichia	1MW0M@1224,1RNXM@1236,3XM7E@561,COG0780@1,COG0780@2,COG2904@1,COG2904@2	NA|NA|NA	F	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
b2795	155864.EDL933_3976	8.5e-262	909.1	Escherichia	ygdH	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464,GO:0047405	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240		R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000				Escherichia	1MVQJ@1224,1RQHX@1236,3XN7C@561,COG1611@1,COG1611@2	NA|NA|NA	S	Catalyzes the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5-phosphate and the corresponding free base. Can use AMP, GMP, IMP, CMP, dTMP and UMP as substrates. Cannot catalyze the reverse reactions
b2796	155864.EDL933_3977	1.1e-231	808.9	Escherichia	sdaC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K03837					ko00000,ko02000	2.A.42.2.1		iAPECO1_1312.APECO1_3735,iE2348C_1286.E2348C_3063,iECABU_c1320.ECABU_c30650,iECED1_1282.ECED1_3249,iECNA114_1301.ECNA114_2835,iECOK1_1307.ECOK1_3172,iECP_1309.ECP_2778,iECS88_1305.ECS88_3065,iECSF_1327.ECSF_2587,iEcSMS35_1347.EcSMS35_2936,iLF82_1304.LF82_2096,iNRG857_1313.NRG857_13695,iSDY_1059.SDY_3013,iUMN146_1321.UM146_02585,iUTI89_1310.UTI89_C3167,ic_1306.c3364	Escherichia	1NQFA@1224,1RQ8Q@1236,3XMD0@561,COG0814@1,COG0814@2	NA|NA|NA	E	Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity
b2797	316407.85675616	2e-258	897.9	Escherichia	sdaB	GO:0003674,GO:0003824,GO:0003941,GO:0006082,GO:0006520,GO:0006563,GO:0006565,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230		R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000				Escherichia	1MUZN@1224,1RMJZ@1236,3XNJ4@561,COG1760@1,COG1760@2	NA|NA|NA	E	L-serine dehydratase
b2798	316407.85675617	1.5e-143	515.4	Escherichia	xni	GO:0000287,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0017108,GO:0022616,GO:0030955,GO:0031420,GO:0033567,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046872,GO:0048256,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901576		ko:K01146					ko00000				Escherichia	1MX9Y@1224,1RQZE@1236,3XNBW@561,COG0258@1,COG0258@2	NA|NA|NA	L	activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment
b2799	155864.EDL933_3980	2.8e-218	764.2	Escherichia	fucO	GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006004,GO:0006066,GO:0008150,GO:0008152,GO:0008198,GO:0008912,GO:0009056,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019299,GO:0019301,GO:0019317,GO:0019318,GO:0019320,GO:0019751,GO:0034311,GO:0034313,GO:0042354,GO:0042355,GO:0042844,GO:0042846,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046365,GO:0046872,GO:0046914,GO:0051143,GO:0055114,GO:0071704,GO:1901575,GO:1901615,GO:1901616	1.1.1.77	ko:K00048	ko00630,ko00640,ko01120,map00630,map00640,map01120		R01781,R02257	RC00087,RC00099	ko00000,ko00001,ko01000			iAF1260.b2799,iECDH1ME8569_1439.ECDH1ME8569_2709,iECSE_1348.ECSE_3059,iECW_1372.ECW_m3009,iEKO11_1354.EKO11_0969,iEcDH1_1363.EcDH1_0889,iEcE24377_1341.EcE24377A_3104,iEcHS_1320.EcHS_A2943,iJO1366.b2799,iJR904.b2799,iUMNK88_1353.UMNK88_3484,iWFL_1372.ECW_m3009,iY75_1357.Y75_RS14565	Escherichia	1MVPH@1224,1RMVU@1236,3XPI7@561,COG1454@1,COG1454@2	NA|NA|NA	C	glycol catabolic process
b2800	198214.SF2814	7.1e-118	429.9	Gammaproteobacteria													Escherichia	1MW7B@1224,1RPIK@1236,COG0235@1,COG0235@2	NA|NA|NA	G	Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde
b2801	316407.85675620	8.5e-243	845.9	Escherichia	fucP	GO:0003674,GO:0005215,GO:0005351,GO:0005354,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0008645,GO:0009679,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015145,GO:0015146,GO:0015149,GO:0015150,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015517,GO:0015518,GO:0015535,GO:0015672,GO:0015749,GO:0015750,GO:0015751,GO:0015756,GO:0015757,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0034219,GO:0034220,GO:0042900,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K02429					ko00000,ko02000	2.A.1.7			Escherichia	1MXDC@1224,1RQX9@1236,3XMV3@561,COG0738@1,COG0738@2	NA|NA|NA	P	Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose
b2802	198214.SF2816	0.0	1211.1	Gammaproteobacteria													Escherichia	1MVD3@1224,1RYI3@1236,COG2407@1,COG2407@2	NA|NA|NA	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose
b2803	316407.85675622	2.8e-276	957.2	Escherichia	fucK	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006004,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008737,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019571,GO:0042354,GO:0042355,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046372,GO:0046835,GO:0071704,GO:1901575	2.7.1.51	ko:K00879	ko00051,ko01120,map00051,map01120		R03241	RC00002,RC00017	ko00000,ko00001,ko01000			iB21_1397.B21_02615,iECB_1328.ECB_02654,iECD_1391.ECD_02654,iECSF_1327.ECSF_2594	Escherichia	1PT3G@1224,1RRVW@1236,3XQF4@561,COG1070@1,COG1070@2	NA|NA|NA	F	Catalyzes the phosphorylation of L-fuculose
b2804	155864.EDL933_3985	1.3e-72	278.9	Escherichia	fucU	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016853,GO:0016854,GO:0016857,GO:0030246,GO:0036094,GO:0042806,GO:0044424,GO:0044464,GO:0048029	5.1.3.29	ko:K02431			R10764	RC00563	ko00000,ko01000				Escherichia	1RJ03@1224,1S27Q@1236,3XPKV@561,COG4154@1,COG4154@2	NA|NA|NA	G	Involved in the anomeric conversion of L-fucose
b2805	198214.SF2819	2e-132	478.4	Gammaproteobacteria													Escherichia	1NVBP@1224,1RXX5@1236,COG1349@1,COG1349@2	NA|NA|NA	K	transcriptional regulator
b2806	155864.EDL933_3987	2e-221	774.6	Escherichia	rlmM	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.186	ko:K06968					ko00000,ko01000,ko03009				Escherichia	1MWBM@1224,1RMSB@1236,3XM5R@561,COG2933@1,COG2933@2	NA|NA|NA	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
b2807	1440052.EAKF1_ch3206	1.9e-65	255.0	Escherichia	ygdD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MZX3@1224,1SCNB@1236,3XPMP@561,COG2363@1,COG2363@2	NA|NA|NA	S	UPF0382 inner membrane protein YgdD
b2808	155864.EDL933_3989	5.7e-169	600.1	Escherichia	gcvA	GO:0001130,GO:0001131,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03566	ko02026,map02026				ko00000,ko00001,ko03000				Escherichia	1MWY0@1224,1RP7Q@1236,3XP9I@561,COG0583@1,COG0583@2	NA|NA|NA	K	Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter
b2809	155864.EDL933_3990	1.9e-33	147.9	Escherichia	ygdI												Escherichia	1N053@1224,1S9DM@1236,2E9MC@1,32RSI@2,3XQ0I@561	NA|NA|NA	M	Bacterial protein of unknown function (DUF903)
b2810	316407.85675629	5.4e-228	796.6	Escherichia	csdA	GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564		ko:K01766					ko00000,ko01000			iAPECO1_1312.APECO1_3722,iECS88_1305.ECS88_3079	Escherichia	1MUPD@1224,1RNIY@1236,3XPAM@561,COG0520@1,COG0520@2	NA|NA|NA	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine, and transiently retains the released sulfur atom on a cysteine residue, in the form of a persulfide. Can also desulfinate L-cysteine sulfinate, which is the best substrate of the enzyme. Functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. Seems to participate in Fe S biogenesis by recruiting the SufBCD- SufE proteins. Transfers sulfur to CsdE that increases the cysteine desulfurase activity of CsdA. Can also transfer sulfur directly to TcdA CsdL in vitro. Appears to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine
b2811	155864.EDL933_3992	1.3e-75	288.9	Escherichia	csdE	GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0061504,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360		ko:K02426					ko00000				Escherichia	1REQB@1224,1S44J@1236,3XMXS@561,COG2166@1,COG2166@2	NA|NA|NA	S	Stimulates the cysteine desulfurase activity of CsdA. Contains a cysteine residue (Cys-61) that acts to accept sulfur liberated via the desulfurase activity of CsdA. May be able to transfer sulfur to TcdA CsdL. Seems to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine. Does not appear to participate in Fe S biogenesis
b2812	316407.85675631	1.8e-147	528.5	Escherichia	ygdL	GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0030955,GO:0031402,GO:0031420,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0061503,GO:0061504,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360		ko:K22132					ko00000,ko03016				Escherichia	1MWXR@1224,1RMT3@1236,3XN7M@561,COG1179@1,COG1179@2	NA|NA|NA	H	Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine. TcdA is also part of a sulfur transfer pathway
b2813	316407.85675632	8.2e-215	752.7	Escherichia	mltA	GO:0000270,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016787,GO:0016798,GO:0019867,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K08304					ko00000,ko01000,ko01011		GH102	iECABU_c1320.ECABU_c30840	Escherichia	1MXD4@1224,1RP7K@1236,3XMK4@561,COG2821@1,COG2821@2	NA|NA|NA	M	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
b2817	155864.EDL933_3995	1.8e-226	791.6	Escherichia	amiC	GO:0000003,GO:0000910,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0008745,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019954,GO:0022402,GO:0022414,GO:0030288,GO:0030313,GO:0031975,GO:0032505,GO:0042597,GO:0043093,GO:0044464,GO:0051301,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036			iSDY_1059.SDY_3034	Escherichia	1MUQK@1224,1RMP1@1236,3XNFF@561,COG0860@1,COG0860@2	NA|NA|NA	M	Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family
b2818	199310.c3412	1.1e-250	872.1	Escherichia	argA	GO:0003674,GO:0003824,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920	Escherichia	1MUUP@1224,1RMV5@1236,3XMQ7@561,COG0548@1,COG0548@2,COG1246@1,COG1246@2	NA|NA|NA	E	Belongs to the acetyltransferase family. ArgA subfamily
b2819	316407.85675635	0.0	1191.0	Escherichia	recD	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009338,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5	ko:K03581	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Escherichia	1MW43@1224,1RPA0@1236,3XPFB@561,COG0507@1,COG0507@2	NA|NA|NA	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
b2820	316407.85675636	0.0	2354.3	Escherichia	recB	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0099046,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5	ko:K03582	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Escherichia	1MUTF@1224,1RPC6@1236,3XMKV@561,COG1074@1,COG1074@2	NA|NA|NA	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA
b2821	316407.85675637	0.0	1896.3	Escherichia	ptrA	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.24.55	ko:K01407					ko00000,ko01000,ko01002				Escherichia	1QTVC@1224,1T1IG@1236,3XNBP@561,COG1025@1,COG1025@2	NA|NA|NA	O	Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin
b2822	316407.85675638	0.0	2293.8	Escherichia	recC	GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0099046,GO:0140097,GO:1901360,GO:1902494	3.1.11.5	ko:K03583	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Escherichia	1MWTI@1224,1RNT0@1236,3XMIF@561,COG1330@1,COG1330@2	NA|NA|NA	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
b2823	316407.85675639	4e-53	213.8	Escherichia	ppdC			ko:K02681					ko00000,ko02044				Escherichia	1N1S1@1224,1S9AD@1236,3XPX3@561,COG4967@1,COG4967@2	NA|NA|NA	NU	Type II secretion prepilin peptidase dependent protein C
b2824	316407.85675640	1.3e-69	268.9	Escherichia	ygdB												Escherichia	1MY9J@1224,1S83V@1236,2E4K6@1,32R55@2,3XPRP@561	NA|NA|NA	S	Protein of unknown function (DUF2509)
b2825	316407.85675641	3.1e-101	374.4	Escherichia	ppdB			ko:K02680					ko00000,ko02044				Escherichia	1RHSZ@1224,1S374@1236,3XN7W@561,COG4795@1,COG4795@2	NA|NA|NA	U	Prepilin peptidase dependent protein B
b2826	316407.85675642	2.3e-89	334.7	Escherichia	ppdA			ko:K02679					ko00000,ko02044				Escherichia	1RDKI@1224,1S4ND@1236,3XN4R@561,COG2165@1,COG2165@2	NA|NA|NA	NU	Prokaryotic N-terminal methylation motif
b2827	1440052.EAKF1_ch3189	2.1e-159	568.2	Escherichia	thyA	GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000			iAF1260.b2827,iAPECO1_1312.APECO1_3678,iBWG_1329.BWG_2562,iE2348C_1286.E2348C_3096,iEC042_1314.EC042_3024,iEC55989_1330.EC55989_3103,iECABU_c1320.ECABU_c31240,iECDH10B_1368.ECDH10B_2997,iECDH1ME8569_1439.ECDH1ME8569_2734,iECED1_1282.ECED1_3283,iECH74115_1262.ECH74115_4093,iECIAI1_1343.ECIAI1_2935,iECIAI39_1322.ECIAI39_3246,iECNA114_1301.ECNA114_2885,iECO103_1326.ECO103_3386,iECO111_1330.ECO111_3555,iECO26_1355.ECO26_3899,iECOK1_1307.ECOK1_3231,iECP_1309.ECP_2840,iECS88_1305.ECS88_3122,iECSE_1348.ECSE_3084,iECSF_1327.ECSF_2642,iECSP_1301.ECSP_3779,iECUMN_1333.ECUMN_3154,iECW_1372.ECW_m3069,iECs_1301.ECs3684,iEKO11_1354.EKO11_0914,iETEC_1333.ETEC_3014,iEcDH1_1363.EcDH1_0864,iEcE24377_1341.EcE24377A_3147,iEcSMS35_1347.EcSMS35_2974,iG2583_1286.G2583_3481,iJO1366.b2827,iJR904.b2827,iLF82_1304.LF82_2267,iNRG857_1313.NRG857_13965,iSSON_1240.SSON_2984,iUMN146_1321.UM146_02290,iUMNK88_1353.UMNK88_3511,iUTI89_1310.UTI89_C3229,iWFL_1372.ECW_m3069,iY75_1357.Y75_RS14705,iZ_1308.Z4144,ic_1306.c3422	Escherichia	1MUBD@1224,1RPYV@1236,3XNAW@561,COG0207@1,COG0207@2	NA|NA|NA	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
b2828	155864.EDL933_4007	2.9e-170	604.4	Escherichia	lgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0042157,GO:0042158,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576		ko:K13292					ko00000,ko01000				Escherichia	1MVE3@1224,1RMVK@1236,3XN5H@561,COG0682@1,COG0682@2	NA|NA|NA	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
b2829	316407.85675645	0.0	1412.9	Escherichia	ptsP	GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698	2.7.3.9	ko:K08484	ko02060,map02060				ko00000,ko00001,ko01000,ko02000				Escherichia	1QTTV@1224,1T1H2@1236,3XPFC@561,COG3605@1,COG3605@2	NA|NA|NA	T	Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I- Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins. Enzyme I-Ntr is specific for NPr
b2830	155864.EDL933_4009	1.9e-100	371.7	Escherichia	rppH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0034353,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0043487,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0045935,GO:0046483,GO:0046700,GO:0046872,GO:0048518,GO:0048519,GO:0048522,GO:0050779,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K08311	ko03018,map03018		R10816	RC00002	ko00000,ko00001,ko01000,ko03019				Escherichia	1RDGJ@1224,1S3PQ@1236,3XN4C@561,COG0494@1,COG0494@2	NA|NA|NA	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
b4610	469008.B21_04427	5.3e-21	105.9	Gammaproteobacteria													Escherichia	1NDCY@1224,1SFMD@1236,2E8MH@1,332YY@2	NA|NA|NA		
b2831	316407.85675647	1.2e-126	459.1	Escherichia	mutH	GO:0000018,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0031323,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0043765,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1990391		ko:K03573	ko03430,map03430				ko00000,ko00001,ko03400				Escherichia	1MVYX@1224,1RQVV@1236,3XNN5@561,COG3066@1,COG3066@2	NA|NA|NA	L	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair
b2832	155864.EDL933_4012	6.4e-120	436.8	Escherichia	ygdQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MWC9@1224,1T1GE@1236,3XPE9@561,COG0861@1,COG0861@2	NA|NA|NA	P	UPF0053 inner membrane protein YgdQ
b2833	1114922.CIFAM_10_03890	2e-32	144.4	Citrobacter													Escherichia	1N7UN@1224,1SDGH@1236,2E9MC@1,333U0@2,3WYW3@544	NA|NA|NA	S	Bacterial protein of unknown function (DUF903)
b2834	198214.SF2844	6.6e-198	696.4	Gammaproteobacteria													Escherichia	1MV2Y@1224,1RNXH@1236,COG0667@1,COG0667@2	NA|NA|NA	C	Aldo keto reductase
b2835	316407.85675651	3.7e-213	747.3	Escherichia	lplT	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0019637,GO:0031224,GO:0031226,GO:0044237,GO:0044238,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046486,GO:0071704,GO:0071944		ko:K08227					ko00000,ko02000	2.A.1.42		iEC042_1314.EC042_3033,iECIAI39_1322.ECIAI39_3255,iEcSMS35_1347.EcSMS35_2983	Escherichia	1QUAG@1224,1T1RI@1236,3XNIS@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell
b2836	316407.85675652	0.0	1435.2	Escherichia	aas	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008779,GO:0008922,GO:0009058,GO:0009987,GO:0015645,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019752,GO:0031224,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564		R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000			iEC042_1314.EC042_3034	Escherichia	1MWDY@1224,1RRXF@1236,3XPGR@561,COG0204@1,COG0204@2,COG0318@1,COG0318@2	NA|NA|NA	I	Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1
b2837	316407.85675653	5e-190	670.2	Escherichia	galR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02529					ko00000,ko03000				Escherichia	1MU1G@1224,1RMSP@1236,3XNH3@561,COG1609@1,COG1609@2	NA|NA|NA	K	Transcriptional regulator GalR
b2838	316407.85675654	4.3e-244	850.1	Escherichia	lysA	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000			iG2583_1286.G2583_3495	Escherichia	1MUA6@1224,1RMI2@1236,3XNIT@561,COG0019@1,COG0019@2	NA|NA|NA	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
b2839	316407.85675655	4.4e-169	600.5	Escherichia	lysR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0016053,GO:0019222,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0048518,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607											Escherichia	1MX2A@1224,1RPHN@1236,3XMKM@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional activator protein LysR
b2840	316407.85675656	1.1e-127	462.6	Escherichia	ygeA	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054		R00491	RC00302	ko00000,ko00001,ko01000				Escherichia	1MV03@1224,1RMHT@1236,3XP1E@561,COG1794@1,COG1794@2	NA|NA|NA	M	Belongs to the aspartate glutamate racemases family
b2841	155864.EDL933_4022	7.7e-258	896.0	Escherichia	araE	GO:0003674,GO:0005215,GO:0005351,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0008645,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015145,GO:0015146,GO:0015147,GO:0015149,GO:0015150,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015749,GO:0015750,GO:0015751,GO:0015756,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0042882,GO:0042900,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K02100					ko00000,ko02000	2.A.1.1.2		iAF1260.b2841,iBWG_1329.BWG_2577,iEC55989_1330.EC55989_3118,iECDH10B_1368.ECDH10B_3013,iECDH1ME8569_1439.ECDH1ME8569_2748,iECDH1ME8569_1439.EcDH1_0849,iECIAI1_1343.ECIAI1_2951,iECIAI39_1322.ECIAI39_3261,iECO111_1330.ECO111_3570,iECO26_1355.ECO26_3914,iECSE_1348.ECSE_3098,iECUMN_1333.ECUMN_3169,iECW_1372.ECW_m3086,iECs_1301.ECs3698,iEKO11_1354.EKO11_0899,iETEC_1333.ETEC_3028,iEcDH1_1363.EcDH1_0849,iEcE24377_1341.EcE24377A_3162,iEcHS_1320.EcHS_A2988,iG2583_1286.G2583_3498,iJO1366.b2841,iJR904.b2841,iSSON_1240.SSON_3001,iUMNK88_1353.UMNK88_3526,iWFL_1372.ECW_m3086,iY75_1357.Y75_RS14785,iZ_1308.Z4161	Escherichia	1MVKJ@1224,1RMHJ@1236,3XM9W@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b2842	316407.85675658	6.6e-139	500.0	Escherichia	kduD	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0033764,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.127	ko:K00065	ko00040,map00040		R01542	RC00089	ko00000,ko00001,ko01000				Escherichia	1MWB6@1224,1RMZB@1236,3XP6J@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	Catalyzes the reversible reduction of 2,5-diketo-3- deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2- keto-3-deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH (Ref.4). To a lesser extent, can also reduce 5-keto-D-gluconate and oxidize D-gluconate and 1,2- propanediol. Together with KduI, seems to play a role in the catabolism of hexuronates under osmotic stress conditions, substituting for the regular hexuronate degrading enzymes UxaABC and UxuAB whose expression is repressed in these conditions. In vitro, also exhibits NADH- dependent 20-ketosteroid reductase activity against eukaryotic steroid hormone 11-deoxycorticosterone (11-DOC), which is converted into the product 4-pregnen-20,21-diol-3-one. In addition to 11-DOC, five other C21 steroid compounds (11-deoxycortisol, cortisol, corticosterone, cortisone, and 21-hydroxypregnenolone) are reduced by KduD, but steroids lacking the hydroxyl group at C21 position, such as pregnenolone, testosterone propionate, cortisone acetate, or progesterone, cannot be used as substrate
b2843	316407.85675659	4.2e-163	580.5	Escherichia	kduI	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008697,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016853,GO:0016860,GO:0016861,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0042802,GO:0042839,GO:0042840,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0046872,GO:0071704,GO:0072329,GO:1901575	5.3.1.17	ko:K01815	ko00040,map00040		R04383	RC00541	ko00000,ko00001,ko01000				Escherichia	1MU9D@1224,1RPDB@1236,3XPE6@561,COG3717@1,COG3717@2	NA|NA|NA	G	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
b2844	316407.85675660	6.1e-216	756.5	Escherichia	yqeF	GO:0003674,GO:0003824,GO:0003988,GO:0006066,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034308,GO:0034309,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0046165,GO:0046395,GO:0055114,GO:0071270,GO:0071271,GO:0071704,GO:0072329,GO:1901575,GO:1901576,GO:1901615,GO:1901617	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147			iSSON_1240.SSON_3004	Escherichia	1MU5G@1224,1RM93@1236,3XMDN@561,COG0183@1,COG0183@2	NA|NA|NA	I	Belongs to the thiolase family
b2845	155864.EDL933_4026	1.6e-214	751.9	Escherichia	yqeG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1QF5A@1224,1RR18@1236,3XM49@561,COG0814@1,COG0814@2	NA|NA|NA	E	Inner membrane transport protein YqeG
b2846	316407.85675662	9.7e-120	436.0	Escherichia	yqeH												Escherichia	1RFRZ@1224,1S57R@1236,3XQA9@561,COG2771@1,COG2771@2	NA|NA|NA	K	regulation of nucleic acid-templated transcription
b2847	316407.85675663	3.6e-159	567.4	Escherichia	yqeI												Escherichia	1R9DQ@1224,1S07A@1236,3XQNB@561,COG3710@1,COG3710@2	NA|NA|NA	K	intracellular signal transduction
b2848	316407.85675664	7e-86	323.2	Escherichia	yqeJ												Escherichia	1RM49@1224,1S6FX@1236,2BD2N@1,326Q6@2,3XR1D@561	NA|NA|NA		
b2851	316407.85675667	1.1e-91	342.4	Escherichia	ygeG												Escherichia	1RGWG@1224,1TGUR@1236,3XR6B@561,COG0457@1,COG0457@2	NA|NA|NA	S	response to stress
b2852	316407.85675668	7.2e-261	906.0	Escherichia	ygeH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K22486					ko00000,ko03000				Escherichia	1PDUY@1224,1S6EI@1236,3XQU6@561,COG0457@1,COG0457@2,COG3710@1,COG3710@2	NA|NA|NA	K	intracellular signal transduction
b2854	155864.EDL933_4038	6e-72	276.9	Gammaproteobacteria													Escherichia	1MZU4@1224,1RXXU@1236,COG0741@1,COG0741@2	NA|NA|NA	M	Transglycosylase SLT domain
b2855	155864.EDL933_4039	4.2e-77	293.9	Bacteria													Escherichia	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
b2856	316407.85675671	6.6e-22	109.0	Bacteria													Escherichia	COG2197@1,COG2197@2	NA|NA|NA	K	response regulator
b2860	316407.2447044	3.9e-178	630.6	Gammaproteobacteria													Escherichia	1MY62@1224,1RQSR@1236,COG2801@1,COG2801@2	NA|NA|NA	L	cog cog2801
b2861	1440052.EAKF1_ch0283	7.2e-59	233.0	Escherichia													Escherichia	1N0V0@1224,1S7WV@1236,3XRHH@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
b2862	316407.85675676	5.2e-47	193.4	Bacteria													Escherichia	COG3387@1,COG3387@2	NA|NA|NA	G	glucan 1,4-alpha-glucosidase activity
b2863	316407.85675677	7.4e-149	533.1	Escherichia	ygeQ												Escherichia	1MXWR@1224,1RXDR@1236,3XQYV@561,COG3387@1,COG3387@2	NA|NA|NA	G	phosphorylase kinase alphabeta
b2865	316407.85675678	4.7e-129	467.2	Escherichia	ygeR	GO:0000920,GO:0001896,GO:0008150,GO:0008219,GO:0009987,GO:0012501,GO:0051301		ko:K12943					ko00000				Escherichia	1RD24@1224,1RR11@1236,3XNB1@561,COG4942@1,COG4942@2	NA|NA|NA	M	autolysis
b2866	316407.85675679	0.0	1496.5	Escherichia	xdhA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000			iEcHS_1320.EcHS_A3026	Escherichia	1MUEA@1224,1RN40@1236,3XQ6N@561,COG1529@1,COG1529@2	NA|NA|NA	F	Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism)
b2867	316407.85675680	4.8e-165	587.0	Escherichia	xdhB	GO:0000166,GO:0003674,GO:0003824,GO:0004854,GO:0005488,GO:0006139,GO:0006144,GO:0006145,GO:0006150,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009114,GO:0009987,GO:0016491,GO:0016725,GO:0016726,GO:0019439,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046100,GO:0046113,GO:0046483,GO:0046700,GO:0048037,GO:0050660,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071949,GO:0072521,GO:0072523,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575	1.17.1.4	ko:K13479	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000			iLF82_1304.LF82_2444,iNRG857_1313.NRG857_14070,iS_1188.S3069	Escherichia	1RCRH@1224,1T26M@1236,3XN3Q@561,COG1319@1,COG1319@2	NA|NA|NA	F	Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism)
b2868	316407.85675681	4.4e-88	330.5	Escherichia	xdhC			ko:K13480	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002			iECH74115_1262.ECH74115_4158,iECSP_1301.ECSP_3838,iECs_1301.ECs3741,iZ_1308.Z4207	Escherichia	1RD8C@1224,1S40Y@1236,3XNQJ@561,COG2080@1,COG2080@2	NA|NA|NA	F	Xanthine dehydrogenase iron-sulfur-binding subunit
b2869	316407.85675682	0.0	1161.7	Escherichia	ygeV	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1NU8B@1224,1RMHY@1236,3XN69@561,COG3829@1,COG3829@2	NA|NA|NA	K	transcriptional regulator
b2870	199310.c3448	5.4e-228	796.6	Escherichia	ygeW	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0019627,GO:0034641,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576											Escherichia	1N4DE@1224,1RSHV@1236,3XPB7@561,COG0078@1,COG0078@2	NA|NA|NA	F	carbamoyltransferase YgeW
b2871	155864.EDL933_4072	2.5e-233	814.3	Escherichia	ygeX	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008838,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575	4.3.1.15	ko:K01751					ko00000,ko01000			iECED1_1282.ECED1_3331	Escherichia	1QTY3@1224,1RPCW@1236,3XN3A@561,COG1171@1,COG1171@2	NA|NA|NA	E	Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate (DAP) to form pyruvate and ammonia
b2872	155864.EDL933_4073	1e-242	845.5	Escherichia	ygeY												Escherichia	1N20R@1224,1RYRN@1236,3XNF6@561,COG0624@1,COG0624@2	NA|NA|NA	E	metallopeptidase activity
b2873	316407.85675686	4.7e-276	956.4	Escherichia	hyuA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016787,GO:0016810,GO:0016812,GO:0042802	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147				Escherichia	1MW10@1224,1RMQC@1236,3XMJE@561,COG0044@1,COG0044@2	NA|NA|NA	F	Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is
b2874	316407.85675687	6.4e-168	596.7	Escherichia	yqeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200		R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_3289	Escherichia	1MWXC@1224,1RP78@1236,3XN33@561,COG0549@1,COG0549@2	NA|NA|NA	E	Belongs to the carbamate kinase family
b2875	316407.85675688	2.1e-307	1060.8	Escherichia	yqeB			ko:K07402					ko00000				Escherichia	1MWFN@1224,1T1CW@1236,3XM3Q@561,COG1975@1,COG1975@2,COG3608@1,COG3608@2	NA|NA|NA	O	XdhC and CoxI family
b2876	316407.85675689	1.6e-148	531.9	Escherichia	yqeC												Escherichia	1N1DB@1224,1S7DT@1236,3XNRG@561,COG0769@1,COG0769@2	NA|NA|NA	M	ATP binding
b2877	316407.85675690	7.8e-108	396.4	Escherichia	ygfJ	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061602,GO:0070567,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902759,GO:1902760	2.7.7.76	ko:K07141	ko00790,map00790		R11582		ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_3649,iB21_1397.B21_02672,iECABU_c1320.ECABU_c31580,iECBD_1354.ECBD_0860,iECB_1328.ECB_02710,iECD_1391.ECD_02710,iEcHS_1320.EcHS_A3037	Escherichia	1QE5N@1224,1S3GJ@1236,3XN3C@561,COG2068@1,COG2068@2	NA|NA|NA	S	Transfers a CMP moiety from CTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin cytosine dinucleotide (Mo-MCD) cofactor. Is specific for CTP
b2878	316407.85675691	0.0	2128.6	Escherichia	ygfK	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0055114	1.97.1.9	ko:K12527	ko00450,map00450		R07229	RC02420	ko00000,ko00001,ko01000				Escherichia	1MU2H@1224,1RREP@1236,3XNXA@561,COG0493@1,COG0493@2,COG1145@1,COG1145@2	NA|NA|NA	C	Could be an iron-sulfur flavoprotein with NADPH O(2) oxidoreductase activity
b2879	316407.85675692	5.9e-260	902.9	Escherichia	ssnA												Escherichia	1MVPA@1224,1TFX9@1236,3XM8H@561,COG0402@1,COG0402@2	NA|NA|NA	F	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
b2880	155864.EDL933_4081	3.8e-142	510.8	Escherichia	ygfM			ko:K12529	ko00450,map00450		R07229	RC02420	ko00000,ko00001				Escherichia	1Q59D@1224,1RZFY@1236,3XPGK@561,COG1319@1,COG1319@2	NA|NA|NA	C	flavin adenine dinucleotide binding
b2881	316407.85675694	0.0	1936.4	Escherichia	xdhD	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914		ko:K12528	ko00450,map00450		R07229	RC02420	ko00000,ko00001				Escherichia	1MUEA@1224,1RN40@1236,3XM8S@561,COG1529@1,COG1529@2,COG2080@1,COG2080@2	NA|NA|NA	F	however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage
b2882	155864.EDL933_4083	4.1e-251	873.6	Escherichia	xanQ	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015851,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042906,GO:0042907,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823		ko:K16346					ko00000,ko02000	2.A.40.4.3		iG2583_1286.G2583_3536	Escherichia	1MUN9@1224,1RMGW@1236,3XM9S@561,COG2233@1,COG2233@2	NA|NA|NA	F	Specific, proton motive force-dependent high-affinity transporter for xanthine
b2883	316407.85675696	9.7e-263	912.1	Escherichia	guaD	GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008892,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0016814,GO:0018756,GO:0019239,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046098,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100		R01676	RC00204	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_3170,iECED1_1282.ECED1_3343,iECIAI1_1343.ECIAI1_3003,iECSE_1348.ECSE_3147	Escherichia	1MUPT@1224,1SYCI@1236,3XMAR@561,COG0402@1,COG0402@2	NA|NA|NA	F	guanine catabolic process
b4464	155864.EDL933_4085	4.7e-236	823.5	Escherichia	ygfQ	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823		ko:K06901					ko00000,ko02000	2.A.1.40			Escherichia	1MUV0@1224,1RMBE@1236,3XNZX@561,COG2252@1,COG2252@2	NA|NA|NA	S	guanine transport
b2886	316407.85675698	6.9e-81	306.6	Escherichia	ygfS	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114											Escherichia	1MWE1@1224,1S33B@1236,3XQP5@561,COG1142@1,COG1142@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
b2887	316407.85675699	0.0	1318.9	Escherichia	ygfT												Escherichia	1MU2H@1224,1RMY7@1236,3XNDT@561,COG0493@1,COG0493@2,COG1142@1,COG1142@2	NA|NA|NA	C	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
b2888	316407.85675700	1.6e-263	914.8	Escherichia	ygfU	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006863,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015143,GO:0015205,GO:0015711,GO:0015747,GO:0015851,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042906,GO:0042907,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098655,GO:0098656,GO:1901702,GO:1904823											Escherichia	1MUN9@1224,1RMGW@1236,3XM66@561,COG2233@1,COG2233@2	NA|NA|NA	F	Proton-dependent high-capacity transporter for uric acid. Shows also a low capacity for transport of xanthine at 37 degrees Celsius but not at 25 degrees Celsius
b4684	199310.c3466	4.2e-11	72.8	Escherichia													Escherichia	1QITG@1224,1TGP0@1236,2AV7P@1,31KYB@2,3XREE@561	NA|NA|NA		
b2889	316407.85675701	6.5e-104	383.3	Escherichia	idi	GO:0003674,GO:0003824,GO:0004452,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0019637,GO:0033554,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046490,GO:0050896,GO:0051716,GO:0071704,GO:0090407,GO:1901576	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000			iECH74115_1262.ECH74115_4179,iECIAI1_1343.ECIAI1_3008,iECO103_1326.ECO103_3464,iECSP_1301.ECSP_3858,iECs_1301.ECs3761,iEcE24377_1341.EcE24377A_3215,iG2583_1286.G2583_3542,iSSON_1240.SSON_3042,iZ_1308.Z4227	Escherichia	1R9YJ@1224,1S6ZT@1236,3XNXM@561,COG1443@1,COG1443@2	NA|NA|NA	I	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
b2890	199310.c3469	1.1e-291	1008.4	Escherichia	lysS	GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016				Escherichia	1MX1V@1224,1RMJN@1236,3XM7X@561,COG1190@1,COG1190@2	NA|NA|NA	J	Belongs to the class-II aminoacyl-tRNA synthetase family
b2891	316407.85675703	1e-187	662.5	Escherichia	prfB	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02836					ko00000,ko03012				Escherichia	1MUAW@1224,1RP9Z@1236,3XNW7@561,COG1186@1,COG1186@2	NA|NA|NA	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
b2892	316407.85675704	0.0	1157.9	Escherichia	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360		ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440				ko00000,ko00001,ko01000,ko03400				Escherichia	1MU1M@1224,1RMF4@1236,3XP91@561,COG0608@1,COG0608@2	NA|NA|NA	L	single-stranded-DNA-specific exonuclease RecJ
b2893	155864.EDL933_4095	2.8e-131	474.6	Escherichia	dsbC	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0055114,GO:0140096	5.3.4.1	ko:K03981					ko00000,ko01000,ko02044,ko03110	3.A.7.11.1		iE2348C_1286.E2348C_3146,iEC042_1314.EC042_3104,iEcSMS35_1347.EcSMS35_3026,iSFV_1184.SFV_2941,iSF_1195.SF2879,iSFxv_1172.SFxv_3158,iS_1188.S3078	Escherichia	1RD39@1224,1S3U8@1236,3XP20@561,COG1651@1,COG1651@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
b2894	1440052.EAKF1_ch3103	2.2e-165	588.2	Escherichia	xerD	GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360		ko:K04763					ko00000,ko03036				Escherichia	1MVNF@1224,1RPI8@1236,3XNCQ@561,COG4974@1,COG4974@2	NA|NA|NA	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids
b2895	155864.EDL933_4097	5.4e-100	370.2	Escherichia	fldB	GO:0000166,GO:0003674,GO:0005488,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03840					ko00000			iEcSMS35_1347.EcSMS35_3028	Escherichia	1QRBW@1224,1RMED@1236,3XMVZ@561,COG0716@1,COG0716@2	NA|NA|NA	C	Low-potential electron donor to a number of redox enzymes
b2896	316407.85675708	9.2e-71	272.7	Escherichia	ygfX	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032091,GO:0043393,GO:0044092,GO:0044425,GO:0044459,GO:0044464,GO:0051098,GO:0051100,GO:0065007,GO:0065009,GO:0071944		ko:K19168					ko00000,ko02048				Escherichia	1RDS7@1224,1S3W7@1236,295KK@1,2ZSY3@2,3XPKK@561	NA|NA|NA	S	inner membrane protein. Has been shown not to be a toxin, no effects on growth are seen in LB or minimal medium up to 6 or 21 hours (respectively) after induction of expression. Interacts with cytoskeletal proteins FtsZ and MreB
b2897	1440052.EAKF1_ch3100	6.7e-46	189.5	Escherichia	ygfY	GO:0006082,GO:0006105,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0017013,GO:0017144,GO:0019538,GO:0019752,GO:0022607,GO:0034552,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0065003,GO:0071704,GO:0071840,GO:1901564		ko:K09159					ko00000,ko02048				Escherichia	1N7P4@1224,1SCKB@1236,3XPU9@561,COG2938@1,COG2938@2	NA|NA|NA	S	Flavinator of succinate dehydrogenase
b2898	198214.SF2884	6.7e-184	649.8	Gammaproteobacteria													Escherichia	1N852@1224,1RPWB@1236,COG0354@1,COG0354@2	NA|NA|NA	S	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication
b2899	155864.EDL933_4102	6.4e-114	416.8	Escherichia	yqfA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K11068					ko00000,ko02042				Escherichia	1PGRH@1224,1RR4R@1236,3XMNM@561,COG1272@1,COG1272@2	NA|NA|NA	S	UPF0073 inner membrane protein YqfA
b2900	1440052.EAKF1_ch3096	5.6e-52	209.9	Escherichia	yqfB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09900					ko00000				Escherichia	1N1TE@1224,1SB7Z@1236,3XPR9@561,COG3097@1,COG3097@2	NA|NA|NA	S	Belongs to the UPF0267 family
b2901	316407.85675713	1.3e-297	1028.1	Escherichia	bglA	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008422,GO:0015926,GO:0016787,GO:0016798,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901657	3.2.1.86	ko:K01223	ko00010,ko00500,map00010,map00500		R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000		GT1	iEC55989_1330.EC55989_3188,iSSON_1240.SSON_3054	Escherichia	1MWG6@1224,1RMM2@1236,3XM82@561,COG2723@1,COG2723@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 1 family
b2902	316407.85675714	4.5e-132	477.2	Escherichia	ygfF												Escherichia	1MW9A@1224,1RMMZ@1236,3XP5I@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	oxidoreductase activity
b2903	316407.85675715	0.0	1907.9	Escherichia	gcvP	GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016642,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_3318	Escherichia	1MUDP@1224,1RND3@1236,3XM76@561,COG0403@1,COG0403@2,COG1003@1,COG1003@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
b2904	155864.EDL933_4106	9.4e-65	252.7	Escherichia	gcvH	GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681		ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002			iE2348C_1286.E2348C_3156	Escherichia	1RGV7@1224,1S656@1236,3XPN3@561,COG0509@1,COG0509@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
b2905	316407.85675717	5.5e-211	740.0	Escherichia	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000			iSFV_1184.SFV_2953	Escherichia	1MV96@1224,1RN2A@1236,3XMM9@561,COG0404@1,COG0404@2	NA|NA|NA	E	The glycine cleavage system catalyzes the degradation of glycine
b2906	316407.85675718	5.2e-231	806.6	Escherichia	visC	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663		ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R08768	RC00046	ko00000,ko00001,ko00002,ko01000				Escherichia	1MU6I@1224,1RND5@1236,3XMGD@561,COG0654@1,COG0654@2	NA|NA|NA	CH	FAD-dependent monooxygenase required for the aerobic hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy- phenol, the first hydroxylation step in coenzyme Q (ubiquinone) biosynthesis
b2907	316407.85675719	3.6e-224	783.9	Escherichia	ubiH	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008681,GO:0009058,GO:0009108,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016705,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0050896,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663		ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_02702,iECBD_1354.ECBD_0830,iECB_1328.ECB_02739,iECD_1391.ECD_02739,iEcHS_1320.EcHS_A3066	Escherichia	1MU6I@1224,1RMS3@1236,3XNK9@561,COG0654@1,COG0654@2	NA|NA|NA	CH	2-octaprenyl-6-methoxyphenol hydroxylase
b2908	316407.85675720	1e-256	892.1	Escherichia	pepP	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.9	ko:K01262					ko00000,ko01000,ko01002				Escherichia	1MUZS@1224,1RN0W@1236,3XN21@561,COG0006@1,COG0006@2	NA|NA|NA	E	metalloexopeptidase activity
b2909	198214.SF2895	3.5e-108	397.5	Gammaproteobacteria													Escherichia	1N7W0@1224,1SCPW@1236,COG3079@1,COG3079@2	NA|NA|NA	S	Belongs to the UPF0149 family
b2910	1440052.EAKF1_ch3084c	8.5e-43	179.5	Escherichia	zapA	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000921,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032185,GO:0032505,GO:0032506,GO:0034622,GO:0042802,GO:0043093,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051301,GO:0061640,GO:0065003,GO:0070925,GO:0071840,GO:0090529,GO:1902410,GO:1903047		ko:K09888					ko00000,ko03036				Escherichia	1N6YN@1224,1SCBI@1236,3XPRT@561,COG3027@1,COG3027@2	NA|NA|NA	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
b2912	155864.EDL933_4114	1.2e-102	379.0	Escherichia	ygfA	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100		R02301	RC00183	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iUTI89_1310.UTI89_C3298	Escherichia	1MZG0@1224,1S612@1236,3XN1C@561,COG0212@1,COG0212@2	NA|NA|NA	H	Involved in the removal of 5-formyltetrahydrofolate. In vitro, it is a potent inhibitor of various folate-dependent enzymes in the C1 metabolism network and in vivo it might function as a folate storage. 5-formyltetrahydrofolate is also used as an antifolate rescue agent in cancer chemotherapy. Catalyzes the irreversible ATP-dependent transformation of 5- formyltetrahydrofolate (5-CHO-THF) to form 5,10- methenyltetrahydrofolate (5,10-CH THF). The reverse reaction is catalyzed by the serine hydroxymethyltransferase GlyA (SHMT)
b2913	155864.EDL933_4115	2.7e-230	804.3	Escherichia	serA	GO:0003674,GO:0003824,GO:0004617,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008219,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0012501,GO:0016053,GO:0016491,GO:0016597,GO:0016614,GO:0016616,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047545,GO:0055114,GO:0070905,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147				Escherichia	1MU5Z@1224,1RPEY@1236,3XNAF@561,COG0111@1,COG0111@2	NA|NA|NA	E	Catalyzes the reversible oxidation of 3-phospho-D- glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate
b2914	155864.EDL933_4117	1.8e-116	425.2	Escherichia	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000				Escherichia	1MVGR@1224,1RNF8@1236,3XMIS@561,COG0120@1,COG0120@2	NA|NA|NA	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
b2915	693444.D782_1039	3e-10	70.9	Gammaproteobacteria													Escherichia	1MXDQ@1224,1SYJV@1236,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
b2916	155864.EDL933_4119	5.2e-167	593.6	Escherichia	argP	GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003700,GO:0005488,GO:0006275,GO:0006355,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032297,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0090329,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000104,GO:2000112,GO:2000113,GO:2001141		ko:K05596					ko00000,ko03000,ko03036				Escherichia	1MWUP@1224,1RNIC@1236,3XMCC@561,COG0583@1,COG0583@2	NA|NA|NA	K	Controls the transcription of genes involved in arginine and lysine metabolism
b2917	316407.85675728	0.0	1399.0	Escherichia	scpA	GO:0003674,GO:0003824,GO:0004494,GO:0005488,GO:0008144,GO:0016853,GO:0016866,GO:0019842,GO:0031419,GO:0036094,GO:0046906,GO:0048037,GO:0097159,GO:1901363	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000			iECO111_1330.ECO111_3653,iECO26_1355.ECO26_4004	Escherichia	1MUXX@1224,1RSHX@1236,3XMZG@561,COG1884@1,COG1884@2,COG2185@1,COG2185@2	NA|NA|NA	I	Methylmalonyl-CoA mutase
b2918	316407.85675729	1.8e-184	651.7	Escherichia	argK	GO:0003674,GO:0003824,GO:0003924,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111		ko:K07588					ko00000,ko01000				Escherichia	1MVI0@1224,1RP15@1236,3XP3F@561,COG1703@1,COG1703@2	NA|NA|NA	E	Binds and hydrolyzes GTP. Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivation of the enzyme during catalysis
b2919	155864.EDL933_4122	1.6e-143	515.4	Escherichia	scpB	GO:0003674,GO:0003824,GO:0004300,GO:0004492,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.1.1.41	ko:K11264	ko00640,map00640		R00923	RC00097	ko00000,ko00001,ko01000			iSSON_1240.SSON_3070	Escherichia	1R3SQ@1224,1RR23@1236,3XP4S@561,COG1024@1,COG1024@2	NA|NA|NA	I	Catalyzes the decarboxylation of methylmalonyl-CoA to propionyl-CoA. Could be part of a pathway that converts succinate to propionate
b2920	316407.85675731	2.9e-284	983.8	Escherichia	scpC	GO:0003674,GO:0003824,GO:0003986,GO:0006082,GO:0006083,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008410,GO:0008775,GO:0009987,GO:0016289,GO:0016740,GO:0016782,GO:0016787,GO:0016788,GO:0016790,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0043821,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0071704		ko:K22214	ko00640,map00640		R11773		ko00000,ko00001,ko01000			iECIAI1_1343.ECIAI1_3040,iECSE_1348.ECSE_3182,iECW_1372.ECW_m3175,iEKO11_1354.EKO11_0812,iWFL_1372.ECW_m3175	Escherichia	1MUGE@1224,1RP19@1236,3XMWJ@561,COG0427@1,COG0427@2	NA|NA|NA	C	Catalyzes the transfer of coenzyme A from propionyl-CoA to succinate. Could be part of a pathway that converts succinate to propionate
b2921	316407.85675732	5.5e-169	600.1	Escherichia	ygfI	GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Escherichia	1R44I@1224,1S19F@1236,3XN51@561,COG0583@1,COG0583@2	NA|NA|NA	K	DNA-binding transcription factor activity
b2922	155864.EDL933_4126	5.1e-128	463.8	Escherichia	yggE	GO:0000302,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0033554,GO:0034599,GO:0034605,GO:0034614,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071575,GO:0071944,GO:0098552,GO:1901700,GO:1901701		ko:K09807					ko00000				Escherichia	1RH7T@1224,1RP7T@1236,3XNCG@561,COG2968@1,COG2968@2	NA|NA|NA	S	cellular response to heat
b2923	316407.85675734	2.1e-114	418.3	Escherichia	argO	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015174,GO:0015181,GO:0015318,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902023,GO:1903825,GO:1903826,GO:1905039,GO:1990822		ko:K06895					ko00000,ko02000	2.A.75.1			Escherichia	1RD6B@1224,1RR03@1236,3XN2X@561,COG1279@1,COG1279@2	NA|NA|NA	S	Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine
b2924	155864.EDL933_4128	6.1e-133	480.3	Escherichia	mscS	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022607,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055082,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066		ko:K03442					ko00000,ko02000	1.A.23.2			Escherichia	1N596@1224,1RQZP@1236,3XMPN@561,COG0668@1,COG0668@2	NA|NA|NA	M	Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage
b2925	155864.EDL933_4129	1.2e-207	728.8	Escherichia	fbaA	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z4263	Escherichia	1MURX@1224,1RQUC@1236,3XMVJ@561,COG0191@1,COG0191@2	NA|NA|NA	F	Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis
b2926	1440052.EAKF1_ch3067	3.1e-212	744.2	Escherichia	pgk	GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147			iSbBS512_1146.SbBS512_E3351	Escherichia	1MUNU@1224,1RMUQ@1236,3XN0J@561,COG0126@1,COG0126@2	NA|NA|NA	F	Belongs to the phosphoglycerate kinase family
b2927	155864.EDL933_4131	2.1e-193	681.4	Escherichia	epd	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019318,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043891,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0048001,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.2.1.72	ko:K03472	ko00750,ko01100,map00750,map01100	M00124	R01825	RC00242	ko00000,ko00001,ko00002,ko01000				Escherichia	1MU93@1224,1RMBM@1236,3XN8W@561,COG0057@1,COG0057@2	NA|NA|NA	H	Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate
b2928	316407.85675739	1.3e-136	492.3	Escherichia	yggC			ko:K02173					ko00000				Escherichia	1RA07@1224,1SENN@1236,3XQ6S@561,COG1072@1,COG1072@2	NA|NA|NA	F	kinase activity
b2929	316407.85675740	1.7e-90	338.6	Escherichia	yggD	GO:0003674,GO:0003824,GO:0004333,GO:0016829,GO:0016835,GO:0016836											Escherichia	1R8G8@1224,1RZD8@1236,3XMB3@561,COG3722@1,COG3722@2	NA|NA|NA	K	In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate
b2930	316407.85675741	1.2e-180	639.0	Escherichia	yggF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576										iUMNK88_1353.UMNK88_3626	Escherichia	1R5BK@1224,1S16G@1236,3XPBC@561,COG1494@1,COG1494@2	NA|NA|NA	G	Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Also displays a low activity toward glucose 1,6-bisphosphate, and no activity against ribulose 1,5- bisphosphate, fructose 2,6-bisphosphate, or fructose 1-phosphate
b4465	316407.85675742	6.5e-248	862.8	Escherichia	yggP			ko:K19956	ko00051,map00051		R03234	RC00089	ko00000,ko00001,ko01000				Escherichia	1QA80@1224,1RQ2Z@1236,3XN34@561,COG1063@1,COG1063@2	NA|NA|NA	E	oxidoreductase activity
b2933	155864.EDL933_4141	2.9e-257	894.0	Escherichia	cmtA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	2.7.1.197	ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5			Escherichia	1Q9RR@1224,1RN2G@1236,3XMGV@561,COG2213@1,COG2213@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport
b2934	155864.EDL933_4142	3.5e-76	290.8	Escherichia	cmtB	GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0051179,GO:0051234,GO:0071702	2.7.1.197	ko:K02798	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5			Escherichia	1RKSR@1224,1S6J2@1236,3XPPH@561,COG1762@1,COG1762@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport
b2935	316407.85675745	0.0	1332.8	Escherichia	tktA	GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_3141	Escherichia	1MUEY@1224,1RMWP@1236,3XMMK@561,COG0021@1,COG0021@2	NA|NA|NA	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
b2936	316407.85675746	1e-131	476.1	Escherichia	yggG	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0006950,GO:0006970,GO:0006971,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009266,GO:0009279,GO:0009314,GO:0009408,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0034605,GO:0034644,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0070011,GO:0071214,GO:0071470,GO:0071476,GO:0071478,GO:0071482,GO:0071704,GO:0071944,GO:0104004,GO:0140096,GO:1901564		ko:K07387					ko00000,ko01000,ko01002				Escherichia	1NK9F@1224,1RQSJ@1236,3XM4R@561,COG0501@1,COG0501@2	NA|NA|NA	O	Metalloprotease that cleaves substrates preferentially between Phe-Phe residues. Plays a role in response to some stress conditions. Seems to regulate the expression of speB
b2937	1440052.EAKF1_ch3055	8.7e-178	629.4	Escherichia	speB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0030145,GO:0034641,GO:0042401,GO:0043167,GO:0043169,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000			iB21_1397.B21_02730,iECB_1328.ECB_02767,iECD_1391.ECD_02767	Escherichia	1MVFH@1224,1RMH5@1236,3XNY2@561,COG0010@1,COG0010@2	NA|NA|NA	E	Catalyzes the formation of putrescine from agmatine
b2938	316407.85675748	0.0	1330.1	Escherichia	speA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0034641,GO:0042401,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_3590,iE2348C_1286.E2348C_3191,iEC55989_1330.EC55989_3231,iECABU_c1320.ECABU_c32250,iECED1_1282.ECED1_3401,iECIAI1_1343.ECIAI1_3071,iECIAI39_1322.ECIAI39_3358,iECO103_1326.ECO103_3518,iECO26_1355.ECO26_4037,iECOK1_1307.ECOK1_3327,iECP_1309.ECP_2933,iECS88_1305.ECS88_3221,iECSE_1348.ECSE_3207,iECSF_1327.ECSF_2737,iECSP_1301.ECSP_3909,iECUMN_1333.ECUMN_3290,iECW_1372.ECW_m3198,iECs_1301.ECs3814,iEKO11_1354.EKO11_0788,iEcE24377_1341.EcE24377A_3281,iEcHS_1320.EcHS_A3096,iEcolC_1368.EcolC_0773,iG2583_1286.G2583_3597,iLF82_1304.LF82_2157,iNRG857_1313.NRG857_14440,iSBO_1134.SBO_3051,iSDY_1059.SDY_3134,iSSON_1240.SSON_3092,iSbBS512_1146.SbBS512_E3371,iWFL_1372.ECW_m3198,iZ_1308.Z4283	Escherichia	1MU80@1224,1RP2J@1236,3XMWR@561,COG1166@1,COG1166@2	NA|NA|NA	H	Catalyzes the biosynthesis of agmatine from arginine
b2939	155864.EDL933_4149	6e-16	89.0	Escherichia	yqgB												Escherichia	1NHU0@1224,1SGJ0@1236,2ESCK@1,33JXD@2,3XRCP@561	NA|NA|NA	S	Virulence promoting factor
b2940	316407.85675750	8.3e-31	139.0	Gammaproteobacteria													Escherichia	1P7YV@1224,1STZK@1236,2C21F@1,2ZIDX@2	NA|NA|NA	S	Uncharacterized yqgC
b2941	316407.85675751	2.6e-39	167.5	Gammaproteobacteria													Escherichia	1PBF5@1224,1SU2F@1236,2C4JF@1,2ZP5F@2	NA|NA|NA	S	Protein of unknown function (DUF2684)
b2942	155864.EDL933_4152	1.3e-210	738.8	Escherichia	metK	GO:0000096,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006556,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009069,GO:0009108,GO:0009116,GO:0009119,GO:0009987,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0030955,GO:0031420,GO:0032553,GO:0032555,GO:0032559,GO:0033353,GO:0034641,GO:0035639,GO:0036094,GO:0042278,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046872,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901605,GO:1901657	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000				Escherichia	1MUFQ@1224,1RNV6@1236,3XP3M@561,COG0192@1,COG0192@2	NA|NA|NA	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
b2943	199310.c3529	9.9e-258	895.6	Escherichia	galP	GO:0003674,GO:0005215,GO:0005351,GO:0005354,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0008645,GO:0009679,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015145,GO:0015149,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015517,GO:0015672,GO:0015749,GO:0015757,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034219,GO:0034220,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K08137					ko00000,ko02000	2.A.1.1.1		iG2583_1286.G2583_3602	Escherichia	1MVKJ@1224,1RMHJ@1236,3XN94@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b2944	316407.85675754	3.4e-91	340.9	Escherichia	sprT			ko:K02742					ko00000				Escherichia	1RJW4@1224,1S70F@1236,3XP6D@561,COG3091@1,COG3091@2	NA|NA|NA	S	Belongs to the SprT family
b2945	316407.85675755	5.6e-124	450.3	Escherichia	endA	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	3.1.21.1	ko:K01150					ko00000,ko01000				Escherichia	1MXQM@1224,1RPX9@1236,3XN9S@561,COG2356@1,COG2356@2	NA|NA|NA	L	deoxyribonuclease I activity
b2946	155864.EDL933_4157	1.5e-135	488.8	Escherichia	rsmE	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.193	ko:K09761					ko00000,ko01000,ko03009				Escherichia	1MXCU@1224,1RPBN@1236,3XN95@561,COG1385@1,COG1385@2	NA|NA|NA	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit
b2947	316407.85675757	2.5e-183	647.9	Escherichia	gshB	GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_3410,iECP_1309.ECP_2941	Escherichia	1MVUA@1224,1RMU0@1236,3XNGA@561,COG0189@1,COG0189@2	NA|NA|NA	F	glutathione synthase activity
b2948	155864.EDL933_4159	1.6e-102	378.6	Escherichia	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07735					ko00000,ko03000				Escherichia	1RCXM@1224,1S3YV@1236,3XNIK@561,COG1678@1,COG1678@2	NA|NA|NA	K	Belongs to the UPF0301 (AlgH) family
b2949	199310.c3535	2e-73	281.6	Escherichia	yqgF	GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360		ko:K07447					ko00000,ko01000				Escherichia	1RDHZ@1224,1S96Q@1236,3XPKW@561,COG0816@1,COG0816@2	NA|NA|NA	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
b2950	316407.85675760	4e-181	640.6	Escherichia	yggR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02669					ko00000,ko02035,ko02044	3.A.15.2			Escherichia	1MU3J@1224,1RN8G@1236,3XN5A@561,COG2805@1,COG2805@2	NA|NA|NA	NU	ATP binding
b2951	155864.EDL933_4163	9.2e-127	459.5	Escherichia	yggS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363		ko:K06997					ko00000				Escherichia	1MWN7@1224,1RNPM@1236,3XM2S@561,COG0325@1,COG0325@2	NA|NA|NA	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
b2952	155864.EDL933_4164	1.2e-92	345.9	Escherichia	yggT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02221					ko00000,ko02044				Escherichia	1RCZV@1224,1S6DW@1236,3XNT9@561,COG0762@1,COG0762@2	NA|NA|NA	S	YGGT family
b2953	316407.85675763	1.5e-46	191.8	Escherichia	yggU			ko:K09131					ko00000				Escherichia	1MZ4E@1224,1S9AB@1236,3XPV2@561,COG1872@1,COG1872@2	NA|NA|NA	S	Uncharacterised ACR, YggU family COG1872
b2954	316407.85675764	5.7e-106	390.2	Escherichia	rdgB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230		R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_3247,iECO111_1330.ECO111_3702,iECSE_1348.ECSE_3222,iECW_1372.ECW_m3212,iEKO11_1354.EKO11_0774,iEcE24377_1341.EcE24377A_3298,iWFL_1372.ECW_m3212	Escherichia	1MUK5@1224,1S27C@1236,3XNRH@561,COG0127@1,COG0127@2	NA|NA|NA	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
b2955	316407.85675765	1.1e-225	788.9	Escherichia	yggW	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576											Escherichia	1MU76@1224,1RN6I@1236,3XNIP@561,COG0635@1,COG0635@2	NA|NA|NA	H	Involved in the biosynthesis of porphyrin-containing compound
b2956	316407.85675766	2.1e-188	664.8	Escherichia	yggM												Escherichia	1R82P@1224,1RRVP@1236,28JQ2@1,2Z9G0@2,3XP2M@561	NA|NA|NA	S	Protein of unknown function (DUF1202)
b2957	316407.85675767	3.5e-191	674.1	Escherichia	ansB	GO:0003674,GO:0003824,GO:0004067,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006082,GO:0006520,GO:0006528,GO:0006530,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0032787,GO:0034641,GO:0042597,GO:0042802,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0072329,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110		R00485	RC00010,RC02798	ko00000,ko00001,ko01000				Escherichia	1MWIR@1224,1RNPN@1236,3XP5U@561,COG0252@1,COG0252@2	NA|NA|NA	EJ	Belongs to the asparaginase 1 family
b2958	155864.EDL933_4170	2.1e-126	458.4	Escherichia	yggN												Escherichia	1MXU1@1224,1RPHU@1236,28H6P@1,2Z7J1@2,3XMGC@561	NA|NA|NA	S	Protein of unknown function (DUF2884)
b2959	316407.85675769	1.2e-57	228.8	Escherichia	yggL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09923					ko00000				Escherichia	1RH3U@1224,1S6UT@1236,3XPPI@561,COG3171@1,COG3171@2	NA|NA|NA	S	Protein with unknown function (DUF469)
b2960	198214.SF2957	1.3e-139	502.3	Gammaproteobacteria													Escherichia	1MUWJ@1224,1RMFG@1236,COG0220@1,COG0220@2	NA|NA|NA	J	catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA
b2961	316407.85675771	6.4e-209	733.0	Escherichia	mutY	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360		ko:K03575	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Escherichia	1MUD4@1224,1RMBT@1236,3XNBT@561,COG1194@1,COG1194@2	NA|NA|NA	L	A G-specific adenine glycosylase
b2962	1440052.EAKF1_ch3029c	4e-46	190.3	Escherichia	yggX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887											Escherichia	1MZ2V@1224,1S964@1236,3XPVI@561,COG2924@1,COG2924@2	NA|NA|NA	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
b2963	199310.c3551	2.2e-204	718.0	Escherichia	mltC	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031225,GO:0031975,GO:0033554,GO:0034599,GO:0042221,GO:0042597,GO:0043170,GO:0044425,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0061783,GO:0070887,GO:0071236,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K08306					ko00000,ko01000,ko01011		GH23	iG2583_1286.G2583_3622,iUMNK88_1353.UMNK88_3661	Escherichia	1MW2T@1224,1RM9N@1236,3XN2V@561,COG0741@1,COG0741@2	NA|NA|NA	M	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
b2964	155864.EDL933_4178	6.5e-232	809.7	Escherichia	nupG	GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015212,GO:0015213,GO:0015214,GO:0015858,GO:0015860,GO:0015861,GO:0015862,GO:0015864,GO:0015893,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032238,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0072531,GO:1901264,GO:1901505,GO:1901642		ko:K03289					ko00000,ko02000	2.A.1.10.1		iEcSMS35_1347.EcSMS35_3108	Escherichia	1MWI9@1224,1RMU5@1236,3XNB0@561,COG2211@1,COG2211@2	NA|NA|NA	G	Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force
b2965	316407.85675775	0.0	1460.3	Escherichia	speC	GO:0003674,GO:0003824,GO:0004586,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042401,GO:0043167,GO:0043168,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000			iEcHS_1320.EcHS_A3126	Escherichia	1MWK4@1224,1RMVF@1236,3XNIH@561,COG1982@1,COG1982@2	NA|NA|NA	E	putrescine biosynthetic process from ornithine
b2966	316407.85675776	7.8e-118	429.9	Escherichia	yqgA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07150					ko00000				Escherichia	1MX1D@1224,1RYSH@1236,3XNGF@561,COG1811@1,COG1811@2	NA|NA|NA	S	Protein of unknown function (DUF554)
b2968	316407.85675777	3.9e-93	347.4	Escherichia	yghD			ko:K02462	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Escherichia	1N8VZ@1224,1S8X3@1236,3XNEI@561,COG3149@1,COG3149@2	NA|NA|NA	U	involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
b2969	362663.ECP_3038	8.5e-151	539.7	Escherichia	gspL			ko:K02461	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Escherichia	1NVVW@1224,1S01F@1236,3XNEN@561,COG3297@1,COG3297@2	NA|NA|NA	U	involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
b2970	316407.85675778	3.6e-157	560.8	Escherichia	gspC			ko:K02452	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Escherichia	1RD3I@1224,1RQKA@1236,3XND8@561,COG3031@1,COG3031@2	NA|NA|NA	U	Type II secretion system protein C
b2971	316407.85675779	4.7e-67	260.4	Escherichia	yghG	GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0071944											Escherichia	1P4P0@1224,1SWA2@1236,2B0AA@1,2ZG1M@2,3XPTJ@561	NA|NA|NA	M	cellular response to DNA damage stimulus
b2972	316407.85675780	3.6e-151	540.8	Escherichia	pppA	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016020,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.23.43	ko:K02464,ko:K02654	ko03070,map03070	M00331			ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15,3.A.15.2			Escherichia	1MUZF@1224,1RN90@1236,3XMEH@561,COG1989@1,COG1989@2	NA|NA|NA	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
b4466	316407.85675781	0.0	2978.7	Escherichia	yghJ			ko:K10939	ko05111,map05111				ko00000,ko00001				Escherichia	1N5U6@1224,1RYM4@1236,3XN17@561,COG3064@1,COG3064@2	NA|NA|NA	M	N-terminal domain of M60-like peptidases
b2975	316407.85675782	2.6e-305	1053.9	Escherichia	glcA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K02550					ko00000,ko02000	2.A.14.1.2		iG2583_1286.G2583_3693	Escherichia	1MV13@1224,1RPNW@1236,3XPDD@561,COG1620@1,COG1620@2	NA|NA|NA	P	Glycolate permease glcA
b2976	316407.85675783	0.0	1460.3	Escherichia	glcB	GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0016054,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046395,GO:0046487,GO:0046872,GO:0046912,GO:0071704,GO:0072329,GO:1901575	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000			iECSF_1327.ECSF_2799,iECW_1372.ECW_m3242,iEKO11_1354.EKO11_0745,iWFL_1372.ECW_m3242	Escherichia	1MVEV@1224,1RPVI@1236,3XP66@561,COG2225@1,COG2225@2	NA|NA|NA	C	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
b2977	198214.SF3016	3.3e-52	211.1	Gammaproteobacteria													Escherichia	1RGUD@1224,1S7TR@1236,COG3193@1,COG3193@2	NA|NA|NA	S	protein, possibly involved in utilization of glycolate and propanediol
b4467	316407.85675785	2.5e-236	824.3	Escherichia	glcF	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616		ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130		R00475	RC00042	ko00000,ko00001			iECABU_c1320.ECABU_c33760,iECIAI1_1343.ECIAI1_3119,iECIAI39_1322.ECIAI39_3465,iECNA114_1301.ECNA114_3053,iECP_1309.ECP_3055	Escherichia	1MWTK@1224,1RPAB@1236,3XPGJ@561,COG0247@1,COG0247@2	NA|NA|NA	C	glycolate dehydrogenase activity
b4468	316407.85675786	8.7e-206	722.6	Escherichia	glcE	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616		ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130		R00475	RC00042	ko00000,ko00001			iETEC_1333.ETEC_3246	Escherichia	1MVYV@1224,1RN4G@1236,3XMBG@561,COG0277@1,COG0277@2	NA|NA|NA	C	glycolate dehydrogenase activity
b2979	199310.c3709	3.3e-291	1006.9	Escherichia	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130		R00475	RC00042	ko00000,ko00001,ko01000			iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750	Escherichia	1MU6Y@1224,1RQX2@1236,3XN6A@561,COG0277@1,COG0277@2	NA|NA|NA	C	Glycolate oxidase subunit
b2980	199310.c3710	3.6e-137	494.2	Escherichia	glcC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K11474					ko00000,ko03000				Escherichia	1R8M2@1224,1RZIJ@1236,3XPCH@561,COG2186@1,COG2186@2	NA|NA|NA	K	Activator for the glycolate oxidation locus
b2981	316407.85675789	3.8e-234	817.0	Escherichia	yghO	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Escherichia	1PMA3@1224,1RS1U@1236,3XPHS@561,COG0454@1,COG0456@2	NA|NA|NA	K	acetyltransferase
b2982	316407.1736552	5.6e-194	683.3	Gammaproteobacteria													Escherichia	1MVDK@1224,1RR0T@1236,COG3039@1,COG3039@2	NA|NA|NA	L	COG3039 Transposase and inactivated derivatives IS5 family
b2983	199310.c3720	5.7e-181	640.2	Escherichia	yghQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RDQG@1224,1RMK6@1236,3XMZ2@561,COG2244@1,COG2244@2	NA|NA|NA	S	Polysaccharide biosynthesis protein
b2984	199310.c3721	2.1e-137	495.0	Escherichia	yghR												Escherichia	1R6BR@1224,1RSID@1236,3XMQU@561,COG0125@1,COG0125@2	NA|NA|NA	F	ATP binding
b2985	316407.85675793	2.3e-133	481.5	Escherichia	yghS												Escherichia	1R4NC@1224,1RPR5@1236,3XM9D@561,COG0125@1,COG0125@2	NA|NA|NA	F	ATP binding
b2986	316407.85675794	2.8e-128	464.5	Escherichia	yghT												Escherichia	1N7QZ@1224,1RSDM@1236,3XNH2@561,COG0125@1,COG0125@2	NA|NA|NA	F	ATP binding
b2987	316407.85675795	6.9e-273	946.0	Escherichia	pitB	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661		ko:K16322					ko00000,ko02000	2.A.20.1		iECABU_c1320.ECABU_c33930	Escherichia	1MVXK@1224,1RP0Q@1236,3XM91@561,COG0306@1,COG0306@2	NA|NA|NA	P	phosphate transporter
b2988	198214.SF3035	0.0	1297.0	Gammaproteobacteria													Escherichia	1MW6V@1224,1RQAP@1236,COG0754@1,COG0754@2	NA|NA|NA	E	Glutathionylspermidine synthase
b2989	155864.EDL933_4211	1.3e-170	605.5	Escherichia	yghU	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0015036,GO:0016491,GO:0016667,GO:0055114		ko:K11209					ko00000,ko01000				Escherichia	1MUN3@1224,1RMF7@1236,3XMFV@561,COG0625@1,COG0625@2	NA|NA|NA	O	the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides, such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide, but does not reduce H(2)O(2) or tert- butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity toward 1- chloro-2,4-dinitrobenzene (CDNB) with glutathionylspermidine (GspSH) as the nucleophilic substrate
b2990	155864.EDL933_4212	1.5e-39	168.3	Escherichia	hybG	GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:1901564,GO:1902670		ko:K04653					ko00000				Escherichia	1RGXH@1224,1S96I@1236,3XQ31@561,COG0298@1,COG0298@2	NA|NA|NA	O	May have a specific role in the maturation of the large subunits of HYD1 and HYD2
b2991	1440052.EAKF1_ch2957	1.2e-60	238.8	Escherichia		GO:0003674,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0010467,GO:0016151,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:1901564		ko:K04651					ko00000,ko03110				Escherichia	1MZJH@1224,1S5WG@1236,3XR02@561,COG0375@1,COG0375@2	NA|NA|NA	S	Probably plays a role in a hydrogenase nickel cofactor insertion step
b2992	199310.c3729	1.8e-89	335.1	Escherichia	hybE	GO:0003674,GO:0005488,GO:0005515,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0070678,GO:0071704,GO:1901564											Escherichia	1N813@1224,1S4PE@1236,3XN10@561,COG1773@1,COG1773@2	NA|NA|NA	C	preprotein binding
b2993	316407.85675801	1.1e-83	315.8	Escherichia	hybD	GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564		ko:K03605					ko00000,ko01000,ko01002				Escherichia	1RE1C@1224,1S4H2@1236,3XNSA@561,COG0680@1,COG0680@2	NA|NA|NA	C	Protease involved in the C-terminal processing of HybC, the large subunit of hydrogenase 2. Specifically cleaves off a 15 amino acid peptide from the C-terminus of the precursor of HybC
b2994	1440052.EAKF1_ch2954	0.0	1167.9	Escherichia	hybC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0009897,GO:0009986,GO:0016020,GO:0016151,GO:0019897,GO:0019898,GO:0031232,GO:0031236,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0098552,GO:0098567	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120		R08034	RC00250	ko00000,ko00001,ko01000			ic_1306.c3731	Escherichia	1MWFJ@1224,1RMC3@1236,3XNXZ@561,COG0374@1,COG0374@2	NA|NA|NA	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family
b2995	316407.85675803	5.7e-222	776.5	Escherichia	hybB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944										iAPECO1_1312.APECO1_3427,iE2348C_1286.E2348C_3282,iECABU_c1320.ECABU_c34010,iECOK1_1307.ECOK1_3414,iECS88_1305.ECS88_3377,iUMN146_1321.UM146_01380,iUTI89_1310.UTI89_C3417	Escherichia	1MWYI@1224,1RMUY@1236,3XP4N@561,COG5557@1,COG5557@2	NA|NA|NA	C	Ni Fe-hydrogenase 2 b-type cytochrome subunit
b2996	754331.AEME01000001_gene2565	2.3e-200	704.5	Escherichia	hybA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0006066,GO:0006071,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016052,GO:0019400,GO:0019405,GO:0019563,GO:0019588,GO:0019662,GO:0019751,GO:0031224,GO:0031226,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046164,GO:0046174,GO:0055114,GO:0071704,GO:0071944,GO:1901575,GO:1901615,GO:1901616											Escherichia	1MU1B@1224,1RPF5@1236,3XNNR@561,COG0437@1,COG0437@2	NA|NA|NA	C	Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover
b2997	155864.EDL933_4219	1.9e-219	768.1	Escherichia	hybO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0009897,GO:0009986,GO:0016020,GO:0019897,GO:0019898,GO:0031232,GO:0031236,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0048037,GO:0051536,GO:0051540,GO:0071944,GO:0098552,GO:0098567	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120		R08034	RC00250	ko00000,ko00001,ko01000				Escherichia	1MWAC@1224,1RNTJ@1236,3XMNB@561,COG1740@1,COG1740@2	NA|NA|NA	C	This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake
b2998	155864.EDL933_4221	6.3e-50	203.0	Escherichia	yghW	GO:0001101,GO:0008150,GO:0010033,GO:0042221,GO:0050896,GO:0097305,GO:1901422,GO:1901700											Escherichia	1RHHT@1224,1S71B@1236,2CFWY@1,31RXH@2,3XPZR@561	NA|NA|NA	S	response to butan-1-ol
b4658	362663.ECP_3085	8.4e-63	247.3	Escherichia	yghX		3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130		R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000				Escherichia	1MW7S@1224,1RPGK@1236,3XMUE@561,COG0412@1,COG0412@2	NA|NA|NA	Q	X-Pro dipeptidyl-peptidase (S15 family)
b4755	155864.EDL933_4222	4e-13	79.7	Escherichia	yghX		3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130		R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000				Escherichia	1MW7S@1224,1RPGK@1236,3XMUE@561,COG0412@1,COG0412@2	NA|NA|NA	Q	X-Pro dipeptidyl-peptidase (S15 family)
b3001	316407.85675807	2.4e-200	704.5	Escherichia	yghZ	GO:0003674,GO:0003824,GO:0006081,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0033554,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0050896,GO:0051596,GO:0051716,GO:0055114,GO:0071704,GO:1901575		ko:K19265					ko00000,ko01000			iSBO_1134.SBO_2995	Escherichia	1MU1S@1224,1RMIG@1236,3XMC7@561,COG0667@1,COG0667@2	NA|NA|NA	C	Catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP, which may be formed by non- enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo
b3002	155864.EDL933_4224	2.8e-82	311.2	Escherichia	yqhA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RANN@1224,1S2DE@1236,3XP73@561,COG2862@1,COG2862@2	NA|NA|NA	S	Uncharacterized protein family, UPF0114
b3003	155864.EDL933_4225	2.6e-163	581.3	Escherichia	yghA	GO:0003674,GO:0003824,GO:0004033,GO:0008106,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114											Escherichia	1MW9A@1224,1RMC9@1236,3XNMH@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	alcohol dehydrogenase (NADP+) activity
b3005	155864.EDL933_4227	3.3e-71	274.2	Escherichia	exbD	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0023052,GO:0031224,GO:0031226,GO:0031647,GO:0031992,GO:0032991,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050821,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0065008,GO:0071944,GO:0098796,GO:0098797		ko:K03559					ko00000,ko02000	1.A.30.2.1			Escherichia	1MZ6M@1224,1S82I@1236,3XP84@561,COG0848@1,COG0848@2	NA|NA|NA	U	Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates
b3006	155864.EDL933_4228	2e-124	451.8	Escherichia	exbB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0023052,GO:0031224,GO:0031226,GO:0031647,GO:0031992,GO:0032991,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050821,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0065008,GO:0071944,GO:0098796,GO:0098797		ko:K03561					ko00000,ko02000	1.A.30.2.1		iSBO_1134.SBO_3000,iSbBS512_1146.SbBS512_E3434	Escherichia	1MXHR@1224,1RND2@1236,3XNK7@561,COG0811@1,COG0811@2	NA|NA|NA	U	Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB
b3008	316407.85675812	2.2e-226	791.2	Escherichia	metC	GO:0000096,GO:0000098,GO:0003674,GO:0003824,GO:0004121,GO:0005488,GO:0006082,GO:0006090,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009987,GO:0016054,GO:0016829,GO:0016846,GO:0019448,GO:0019450,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0046395,GO:0046439,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000			iSbBS512_1146.SbBS512_E3435,iUTI89_1310.UTI89_C3428	Escherichia	1MU9E@1224,1RQI0@1236,3XPCU@561,COG0626@1,COG0626@2	NA|NA|NA	E	cystathionine beta-lyase
b3009	155864.EDL933_4230	2.5e-118	431.4	Escherichia	yghB	GO:0000003,GO:0000910,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0019954,GO:0022402,GO:0022414,GO:0022857,GO:0031224,GO:0031226,GO:0032505,GO:0043093,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0071944											Escherichia	1N2EF@1224,1RQKN@1236,3XM2J@561,COG0586@1,COG0586@2	NA|NA|NA	S	inner membrane protein YghB
b3010	316407.85675814	8.5e-176	622.9	Escherichia	yqhC	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141											Escherichia	1MUEM@1224,1RQQK@1236,3XN3T@561,COG2207@1,COG2207@2	NA|NA|NA	K	transcriptional activator activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
b3011	316407.85675815	9.2e-225	785.8	Escherichia	yqhD	GO:0000302,GO:0003674,GO:0003824,GO:0004033,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008106,GO:0008150,GO:0008152,GO:0008270,GO:0016491,GO:0016614,GO:0016616,GO:0018455,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0055114,GO:1901700,GO:1990002		ko:K08325	ko00640,map00640		R02528	RC00739	ko00000,ko00001,ko01000				Escherichia	1QUBJ@1224,1RP7C@1236,3XP5X@561,COG1979@1,COG1979@2	NA|NA|NA	C	alcohol dehydrogenase [NAD(P)+] activity
b3012	316407.85675816	2.8e-159	567.8	Escherichia	dkgA	GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008106,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0055114,GO:0071704,GO:1901575	1.1.1.346	ko:K06221			R08878	RC00089	ko00000,ko01000			iECH74115_1262.ECH74115_4323,iECSP_1301.ECSP_3988	Escherichia	1MWFS@1224,1RMX6@1236,3XMUT@561,COG0656@1,COG0656@2	NA|NA|NA	S	Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG)
b3013	316407.85675817	4.5e-174	617.1	Escherichia	yqhG												Escherichia	1RKYU@1224,1S8BB@1236,2C67P@1,32RGV@2,3XPG9@561	NA|NA|NA	S	Protein of unknown function (DUF3828)
b3014	198214.SF3059	5.8e-39	166.4	Bacteria													Escherichia	COG4238@1,COG4238@2	NA|NA|NA	M	peptidoglycan binding
b4469	316407.85675819	0.0	1537.3	Escherichia	ygiQ												Escherichia	1MUG3@1224,1RN9V@1236,3XN2Q@561,COG1032@1,COG1032@2	NA|NA|NA	C	UPF0313 protein YgiQ
b3017	316407.85675820	9.3e-280	968.8	Escherichia	ftsP	GO:0005575,GO:0005623,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042597,GO:0044464,GO:0050896,GO:0051301		ko:K04753					ko00000				Escherichia	1MU0J@1224,1RN7I@1236,3XNVT@561,COG2132@1,COG2132@2	NA|NA|NA	D	Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress
b3018	316407.85675821	7.1e-138	496.5	Escherichia	plsC	GO:0003674,GO:0003824,GO:0003841,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042171,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071617,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004				Escherichia	1MY51@1224,1RQYC@1236,3XN3R@561,COG0204@1,COG0204@2	NA|NA|NA	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
b3019	155864.EDL933_4242	0.0	1470.3	Escherichia	parC	GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363		ko:K02621					ko00000,ko01000,ko02048,ko03032,ko03036				Escherichia	1MURI@1224,1RMTC@1236,3XNES@561,COG0188@1,COG0188@2	NA|NA|NA	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
b3020	316407.85675823	0.0	1092.4	Escherichia	ygiS	GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0008150,GO:0010876,GO:0015711,GO:0015718,GO:0015721,GO:0015849,GO:0015850,GO:0030288,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702		ko:K02035	ko02024,map02024	M00239			ko00000,ko00001,ko00002,ko02000	3.A.1.5			Escherichia	1R9KS@1224,1RWN5@1236,3XNUG@561,COG4166@1,COG4166@2	NA|NA|NA	E	higher expression in the presence of deoxycholate inhibits cell growth completely. Bile acid detergents such as deoxycholate are important for host defense against bacterial growth in the gall bladder and duodenum
b3021	316407.85675824	9.8e-70	269.2	Escherichia	mqsA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K13655					ko00000,ko02048,ko03000				Escherichia	1N1C3@1224,1SA99@1236,3XQ5B@561,COG2944@1,COG2944@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the MqsR mRNA interferase toxin and neutralizes its endoribonuclease activity. Overexpression prevents MqsR-mediated cessation of cell growth and inhibition of cell proliferation. Initially reported to act as a cotranscription factor with MqsA. Following further experiments, the MqsR-MqsA complex does not bind DNA and all reported data are actually due to a small fraction of free MqsA alone binding DNA. Addition of MqsR to a preformed MqsA-promoter DNA complex causes dissociation of the MqsA-DNA complex, probably causing derepression of MqsA- repressed transcripts. MqsA binds to 2 palindromes in the promoter region of the mqsRA operon activating its transcription. Binds to other promoters, inducing mcbR and spy and repressing cspD among others. Binds to and represses the rpoS promoter, the master stress regulator, resulting in decreased cyclic-di-GMP, reduced stress resistance, increased cell motility and decreased biofilm formation
b3022	316407.85675825	7.9e-48	196.1	Escherichia	mqsR	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006355,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0032268,GO:0032269,GO:0032879,GO:0034248,GO:0034249,GO:0034641,GO:0040012,GO:0042710,GO:0043170,GO:0043487,GO:0043488,GO:0044010,GO:0044237,GO:0044238,GO:0044764,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051270,GO:0051704,GO:0060255,GO:0061013,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1902679,GO:1903311,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2000145,GO:2001141		ko:K13651					ko00000,ko02048				Escherichia	1MZ7W@1224,1S8T9@1236,2D16E@1,32TA0@2,3XRBW@561	NA|NA|NA	K	Toxic component of a type II toxin-antitoxin (TA) system. Plays a significant role in the control of biofilm formation and induction of persister cells in the presence of antibiotics. An mRNA interferase which has been reported to be translation-independent. It has also been reported to be translation- dependent. Cleavage has been reported to occur on either side of G in the sequence GCU. Also reported to cleave after C in GC(A U) sequences. There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity
b3023	316407.85675826	2.1e-90	338.2	Escherichia	ygiV	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K07471					ko00000,ko03000				Escherichia	1QTW6@1224,1T2QK@1236,3XPFY@561,COG3449@1,COG3449@2	NA|NA|NA	K	transcriptional regulator
b3024	155864.EDL933_4245	1.3e-58	232.3	Escherichia	ygiW	GO:0000302,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044011,GO:0044764,GO:0046677,GO:0046686,GO:0050896,GO:0051703,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071236,GO:0071241,GO:0071248,GO:0071276,GO:0090605,GO:0090609,GO:0097237,GO:1901700,GO:1901701											Escherichia	1N9HJ@1224,1SCD7@1236,3XPMM@561,COG3111@1,COG3111@2	NA|NA|NA	S	cellular response to cadmium ion
b3025	316407.85675828	5.4e-121	440.3	Escherichia	qseB	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010035,GO:0010038,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K07666	ko02020,ko02024,map02020,map02024	M00453			ko00000,ko00001,ko00002,ko02022				Escherichia	1N0YI@1224,1RQQ3@1236,3XP78@561,COG0745@1,COG0745@2	NA|NA|NA	K	Member of a two-component regulatory system QseB QseC. Activates the flagella regulon by activating transcription of FlhDC. Currently it is not known whether this effect is direct or not
b3026	316407.85675829	5.6e-250	869.8	Escherichia	qseC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1QTSX@1224,1T1G3@1236,3XN9X@561,COG0642@1,COG0642@2	NA|NA|NA	T	Member of a two-component regulatory system QseB QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation
b3027	316407.85675830	3.4e-55	220.7	Gammaproteobacteria													Escherichia	1N8VS@1224,1SFKV@1236,2E4JB@1,32ZED@2	NA|NA|NA	S	Protein of unknown function (DUF2645)
b3028	155864.EDL933_4248	1.4e-112	412.1	Escherichia	mdaB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008753,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363		ko:K03923					ko00000			iLF82_1304.LF82_1283	Escherichia	1MWV9@1224,1RQ16@1236,3XP9N@561,COG2249@1,COG2249@2	NA|NA|NA	S	Modulator of drug activity B
b3029	155864.EDL933_4249	3e-53	214.2	Escherichia	ygiN	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009268,GO:0009628,GO:0010447,GO:0016491,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114										iEcSMS35_1347.EcSMS35_3317	Escherichia	1RE0B@1224,1S3QV@1236,3XPV5@561,COG1359@1,COG1359@2	NA|NA|NA	S	Can oxidize menadiol to menadione
b3030	316407.85675833	0.0	1268.4	Escherichia	parE	GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360		ko:K02622					ko00000,ko01000,ko02048,ko03032,ko03036				Escherichia	1MVH1@1224,1RMCI@1236,3XND7@561,COG0187@1,COG0187@2	NA|NA|NA	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
b3031	155864.EDL933_4257	1.1e-109	402.5	Escherichia	yqiA	GO:0003674,GO:0003824,GO:0016787,GO:0016788		ko:K07000					ko00000				Escherichia	1MVJF@1224,1S5WF@1236,3XN2H@561,COG3150@1,COG3150@2	NA|NA|NA	S	Displays esterase activity toward palmitoyl-CoA and pNP- butyrate
b3032	155864.EDL933_4258	4.2e-163	580.5	Escherichia	cpdA	GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025		R00191	RC00296	ko00000,ko00001,ko01000				Escherichia	1MWKX@1224,1RPA7@1236,3XNUE@561,COG1409@1,COG1409@2	NA|NA|NA	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
b3033	1440052.EAKF1_ch2896	7.5e-76	289.7	Escherichia	yqiB			ko:K09920					ko00000				Escherichia	1RA4E@1224,1S55I@1236,3XN24@561,COG3151@1,COG3151@2	NA|NA|NA	S	Protein of unknown function (DUF1249)
b3034	155864.EDL933_4260	3e-113	414.5	Escherichia	nudF	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047631,GO:0050896	3.6.1.13	ko:K01515	ko00230,map00230		R01054	RC00002	ko00000,ko00001,ko01000			iECP_1309.ECP_3126	Escherichia	1RDMW@1224,1RPZV@1236,3XP8H@561,COG0494@1,COG0494@2	NA|NA|NA	L	Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process
b3035	316407.85675838	3.2e-254	884.0	Escherichia	tolC	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0009279,GO:0010033,GO:0014070,GO:0015075,GO:0015267,GO:0015288,GO:0015318,GO:0015562,GO:0015688,GO:0015711,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022838,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0034220,GO:0042221,GO:0042493,GO:0042802,GO:0042930,GO:0044425,GO:0044462,GO:0044464,GO:0046618,GO:0047485,GO:0050896,GO:0051179,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098796,GO:1901678,GO:1902495,GO:1990195,GO:1990196,GO:1990281,GO:1990351		ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821			ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2		iAPECO1_1312.APECO1_3378,iEC042_1314.EC042_3326,iECOK1_1307.ECOK1_3463	Escherichia	1MWCJ@1224,1RQQV@1236,3XMC8@561,COG1538@1,COG1538@2	NA|NA|NA	M	Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells
b3036	199310.c3782	2.5e-45	187.6	Escherichia	ygiA												Escherichia	1NVWD@1224,1SPMF@1236,2F4KT@1,33XAB@2,3XR3R@561	NA|NA|NA		
b3037	155864.EDL933_4262	1.1e-100	372.9	Escherichia	ygiB	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944											Escherichia	1MXGU@1224,1RPEV@1236,3XNSY@561,COG5463@1,COG5463@2	NA|NA|NA	S	Protein of unknown function (DUF1190)
b3038	155864.EDL933_4263	1.2e-232	812.0	Escherichia	ygiC												Escherichia	1MW6V@1224,1RQAP@1236,3XN5K@561,COG0754@1,COG0754@2	NA|NA|NA	E	May be a ligase forming an amide bond. Shows ATPase activity
b3039	316407.85675842	4.6e-162	577.0	Escherichia	ygiD	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0046566,GO:0051213,GO:0055114		ko:K15777	ko00965,map00965		R08836	RC00387	ko00000,ko00001,ko01000				Escherichia	1MXJZ@1224,1RR5P@1236,3XNY6@561,COG3384@1,COG3384@2	NA|NA|NA	S	In vitro, opens the cyclic ring of dihydroxy- phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is
b3040	155864.EDL933_4265	2.7e-119	434.9	Escherichia	zupT	GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005384,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0006826,GO:0006828,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015086,GO:0015087,GO:0015093,GO:0015318,GO:0015684,GO:0015691,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0034755,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070574,GO:0070838,GO:0071421,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903874		ko:K07238					ko00000,ko02000	2.A.5.5		iECIAI39_1322.ECIAI39_3536	Escherichia	1MWEZ@1224,1RNXU@1236,3XN1F@561,COG0428@1,COG0428@2	NA|NA|NA	P	Mediates zinc uptake. May also transport other divalent cations
b4756	362663.ECP_3135	4.3e-22	109.8	Escherichia													Escherichia	1P90F@1224,1SVXC@1236,2C0YM@1,2ZEYA@2,3XR86@561	NA|NA|NA	S	Protein of unknown function (DUF4051)
b3041	155864.EDL933_4267	3.2e-118	431.0	Escherichia	ribB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000				Escherichia	1MU8P@1224,1RQ49@1236,3XMEU@561,COG0108@1,COG0108@2	NA|NA|NA	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
b3042	198214.SF3082	5.8e-43	179.9	Gammaproteobacteria													Escherichia	1N7AH@1224,1SCH1@1236,COG2960@1,COG2960@2	NA|NA|NA	S	protein conserved in bacteria
b3043	316407.85675846	3.8e-96	357.5	Escherichia	ygiL												Escherichia	1RC9J@1224,1S359@1236,3XR8P@561,COG3539@1,COG3539@2	NA|NA|NA	NU	cell adhesion
b3044	1440052.EAKF1_ch0283	7.2e-59	233.0	Escherichia													Escherichia	1N0V0@1224,1S7WV@1236,3XRHH@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
b3045	316407.2447044	3.9e-178	630.6	Gammaproteobacteria													Escherichia	1MY62@1224,1RQSR@1236,COG2801@1,COG2801@2	NA|NA|NA	L	cog cog2801
b3047	316407.85675850	1.6e-140	505.4	Escherichia	yqiH	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1MY06@1224,1RN7Y@1236,3XPFT@561,COG3121@1,COG3121@2	NA|NA|NA	M	chaperone
b3048	316407.85675851	3e-198	697.6	Escherichia	yqiI	GO:0008150,GO:0010033,GO:0042221,GO:0050896,GO:0051595,GO:1901654,GO:1901700											Escherichia	1R7A3@1224,1S1D9@1236,3XRG6@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbrial protein
b3049	316407.1805589	1.8e-32	144.4	Escherichia	glgS	GO:0006109,GO:0008150,GO:0009893,GO:0010675,GO:0010676,GO:0019222,GO:0031323,GO:0031325,GO:0032879,GO:0040012,GO:0040013,GO:0043900,GO:0043901,GO:0045913,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0065007,GO:0080090,GO:1900190,GO:1900191,GO:1900231,GO:1900232,GO:1902021,GO:1902201,GO:2000145,GO:2000146											Escherichia	1N89V@1224,1SD5E@1236,2CHAW@1,32ZQX@2,3XQ46@561	NA|NA|NA	S	Major determinant of cell surface composition. Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides
b3050	316407.85675852	5.5e-115	420.2	Escherichia	yqiJ	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944											Escherichia	1R4NP@1224,1RQ4X@1236,3XQV3@561,COG1585@1,COG1585@2	NA|NA|NA	OU	cellular response to DNA damage stimulus
b3051	316407.1805590	2.9e-216	758.1	Escherichia	yqiK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944											Escherichia	1P50K@1224,1RRHJ@1236,3XNVI@561,COG2268@1,COG2268@2	NA|NA|NA	S	Flotillin
b3052	316407.85675853	5.4e-267	926.4	Escherichia	hldE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008219,GO:0009987,GO:0012501,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016779,GO:0019200,GO:0033785,GO:0033786,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0070566,GO:0071704	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005			iECH74115_1262.ECH74115_4363,iECSP_1301.ECSP_4025,iECs_1301.ECs3935,iZ_1308.Z4405	Escherichia	1MV3Z@1224,1RMAJ@1236,3XM6T@561,COG0615@1,COG0615@2,COG2870@1,COG2870@2	NA|NA|NA	F	belongs to the carbohydrate kinase PfkB family
b3053	316407.85675854	0.0	1877.8	Escherichia	glnE	GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008144,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.7.42,2.7.7.89	ko:K00982					ko00000,ko01000				Escherichia	1MU4I@1224,1RP9N@1236,3XP8M@561,COG1391@1,COG1391@2	NA|NA|NA	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell
b3054	316407.85675855	5.4e-250	869.8	Escherichia	ygiF	GO:0003674,GO:0003824,GO:0005488,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0046872,GO:0050355	3.6.1.25	ko:K18446					ko00000,ko01000				Escherichia	1MY43@1224,1RMP4@1236,3XMHT@561,COG3025@1,COG3025@2	NA|NA|NA	S	Involved in the hydrolysis of the beta-gamma- phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked). Catalyzes the hydrolysis of inorganic triphosphate (PPPi), which could be cytotoxic because of its high affinity for calcium ion, thereby interfering with calcium signaling. It also hydrolyzes slowly thiamine triphosphate (ThTP). YgiF is a specific PPPase, but it contributes only marginally to the total PPPase activity in E.coli, where the main enzyme responsible for hydrolysis of PPPi is inorganic pyrophosphatase (PPase)
b3055	155864.EDL933_4276	2.4e-110	404.8	Escherichia	ygiM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944		ko:K07184					ko00000				Escherichia	1MX7M@1224,1RS74@1236,3XN08@561,COG3103@1,COG4991@2	NA|NA|NA	T	Bacterial SH3 domain
b3056	316407.85675857	3.6e-243	847.0	Escherichia	cca	GO:0001680,GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016437,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042245,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990817	2.7.7.72	ko:K00974	ko03013,map03013		R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016				Escherichia	1MU2X@1224,1RPFJ@1236,3XNTY@561,COG0617@1,COG0617@2	NA|NA|NA	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases
b3057	155864.EDL933_4278	2.7e-146	524.6	Escherichia	bacA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031224,GO:0031226,GO:0042221,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050380,GO:0050896,GO:0071944	3.6.1.27	ko:K06153	ko00550,map00550		R05627	RC00002	ko00000,ko00001,ko01000,ko01011				Escherichia	1MX02@1224,1RQQT@1236,3XMCU@561,COG1968@1,COG1968@2	NA|NA|NA	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
b3058	198214.SF3099	1.1e-59	235.7	Gammaproteobacteria													Escherichia	1MZ8Z@1224,1S9B2@1236,COG1539@1,COG1539@2	NA|NA|NA	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
b3059	155864.EDL933_4280	1.5e-112	412.1	Escherichia	plsY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004				Escherichia	1RD4Z@1224,1RN1J@1236,3XP9Z@561,COG0344@1,COG0344@2	NA|NA|NA	I	Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4)
b3060	316407.85675861	1.2e-177	629.0	Escherichia	ttdR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043565,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K21742					ko00000,ko03000				Escherichia	1MVJ7@1224,1RMNJ@1236,3XPYE@561,COG0583@1,COG0583@2	NA|NA|NA	K	Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB- ygjE operon
b3061	316407.85675862	1.1e-169	602.4	Escherichia	ttdA	GO:0008150,GO:0008152,GO:1901275	4.2.1.32	ko:K03779	ko00630,map00630		R00339	RC01382	ko00000,ko00001,ko01000			iLF82_1304.LF82_2330	Escherichia	1MW8J@1224,1RPUD@1236,3XQD3@561,COG1951@1,COG1951@2	NA|NA|NA	C	L( )-tartrate dehydratase subunit alpha
b3062	198214.SF3103	1.8e-115	421.8	Gammaproteobacteria													Escherichia	1MVNG@1224,1RMT4@1236,COG1838@1,COG1838@2	NA|NA|NA	C	)-tartrate dehydratase
b3063	316407.85675864	4.8e-271	939.9	Escherichia	ttdT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015291,GO:0015297,GO:0016020,GO:0022804,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K11106					ko00000,ko02000	2.A.47.3.3		iAF1260.b3063,iBWG_1329.BWG_2774,iECDH10B_1368.ECDH10B_3238,iECDH1ME8569_1439.ECDH1ME8569_2959,iECIAI1_1343.ECIAI1_3211,iETEC_1333.ETEC_3334,iEcDH1_1363.EcDH1_0637,iEcolC_1368.EcolC_0636,iJO1366.b3063,iJR904.b3063,iUMNK88_1353.UMNK88_3815,iY75_1357.Y75_RS15915	Escherichia	1MUSA@1224,1RMF3@1236,3XQHR@561,COG0471@1,COG0471@2	NA|NA|NA	P	Catalyzes the uptake of tartrate in exchange for intracellular succinate. Essential for anaerobic L-tartrate fermentation
b3064	316407.85675865	3.8e-190	670.6	Escherichia	gcp	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:1901360	2.3.1.234	ko:K01409			R10648	RC00070,RC00416	ko00000,ko01000,ko03016				Escherichia	1MU6S@1224,1RN8M@1236,3XM47@561,COG0533@1,COG0533@2	NA|NA|NA	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
b3065	1005994.GTGU_04164	3.5e-29	133.7	Gammaproteobacteria													Escherichia	1MZCC@1224,1S8QZ@1236,COG0828@1,COG0828@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bS21 family
b3066	155864.EDL933_4287	0.0	1175.2	Escherichia	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576		ko:K02316	ko03030,map03030				ko00000,ko00001,ko01000,ko03032				Escherichia	1MUHC@1224,1RMGA@1236,3XNFD@561,COG0358@1,COG0358@2	NA|NA|NA	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
b3067	316407.85675868	0.0	1107.0	Escherichia	rpoD	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043254,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141		ko:K03086					ko00000,ko03021				Escherichia	1MVNJ@1224,1RMQI@1236,3XPCE@561,COG0568@1,COG0568@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
b3068	199310.c3822	5.3e-92	343.6	Escherichia	mug	GO:0000700,GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008263,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.28	ko:K03649	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Escherichia	1R47B@1224,1T0RJ@1236,3XMG7@561,COG3663@1,COG3663@2	NA|NA|NA	L	Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells
b3070	316407.85675870	2.7e-148	531.2	Escherichia	yqjH	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010045,GO:0016491,GO:0016722,GO:0016723,GO:0019725,GO:0030003,GO:0033212,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048037,GO:0048878,GO:0050660,GO:0050662,GO:0050801,GO:0050896,GO:0051716,GO:0052851,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071241,GO:0071248,GO:0071289,GO:0071949,GO:0097159,GO:0098771,GO:1901265,GO:1901363	1.16.1.9	ko:K07229					ko00000,ko01000				Escherichia	1R4TD@1224,1RY01@1236,3XMHN@561,COG2375@1,COG2375@2	NA|NA|NA	P	ferric-chelate reductase (NADPH) activity
b3071	198214.SF3112	6.5e-92	343.6	Gammaproteobacteria													Escherichia	1RHSE@1224,1S255@1236,COG1695@1,COG1695@2	NA|NA|NA	K	transcriptional regulator
b3072	316407.85675872	1e-207	729.6	Escherichia	aer	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0009453,GO:0009454,GO:0009605,GO:0009987,GO:0016020,GO:0023052,GO:0040011,GO:0042221,GO:0042330,GO:0042802,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0050918,GO:0051716,GO:0052128,GO:0052131,GO:0065007,GO:0071944		ko:K03776	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Escherichia	1MU9B@1224,1RMH0@1236,3XMRX@561,COG0840@1,COG0840@2	NA|NA|NA	T	Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a redox sensor to monitor oxygen levels
b3073	316407.85675873	6.6e-262	909.4	Escherichia	patA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0033094,GO:0034641,GO:0036094,GO:0042402,GO:0042802,GO:0043167,GO:0043168,GO:0044106,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901565,GO:1901575	2.6.1.82	ko:K09251	ko00330,ko01100,map00330,map01100		R01155	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007			iECIAI1_1343.ECIAI1_3220,iECSF_1327.ECSF_2916,iECs_1301.ECs3955,iZ_1308.Z4426	Escherichia	1R6U9@1224,1RMRF@1236,3XNZ9@561,COG4992@1,COG4992@2	NA|NA|NA	H	Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine
b3074	316407.85675874	2.4e-53	214.5	Escherichia	ygjH	GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0017101,GO:0017102,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K06878					ko00000				Escherichia	1QUBK@1224,1S46T@1236,3XPT5@561,COG0073@1,COG0073@2	NA|NA|NA	J	tRNA aminoacylation for protein translation
b3075	316407.85675875	2.5e-183	647.9	Escherichia	ebgR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K12113					ko00000,ko03000				Escherichia	1N8ZA@1224,1RSGV@1236,3XP3T@561,COG1609@1,COG1609@2	NA|NA|NA	K	Transcriptional regulator EbgR
b3076	316407.85675876	0.0	2176.4	Escherichia	ebgA	GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005575,GO:0005975,GO:0005984,GO:0005988,GO:0005990,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009341,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0032991,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575,GO:1902494	3.2.1.23	ko:K12111	ko00052,ko00511,ko01100,map00052,map00511,map01100		R01678,R06114	RC00049	ko00000,ko00001,ko01000				Escherichia	1MVBN@1224,1RMER@1236,3XN5C@561,COG3250@1,COG3250@2	NA|NA|NA	G	lactose catabolic process
b3077	199310.c3834	2e-82	311.6	Escherichia	ebgC			ko:K12112	ko00052,ko00511,ko01100,map00052,map00511,map01100		R01678	RC00049	ko00000,ko00001				Escherichia	1RGW2@1224,1S72G@1236,3XPHG@561,COG2731@1,COG2731@2	NA|NA|NA	G	Required for full activity of the EbgA enzyme. Exact function not known
b3078	316407.85675878	1.5e-261	908.3	Escherichia	ygjI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MWXV@1224,1RPPM@1236,3XQFH@561,COG0531@1,COG0531@2	NA|NA|NA	E	transmembrane transporter activity
b3079	316407.85675879	1.3e-217	761.9	Escherichia	ygjJ												Escherichia	1R4J1@1224,1RYGU@1236,28HKS@1,2Z7VJ@2,3XN5X@561	NA|NA|NA		
b3080	316407.85675880	0.0	1629.4	Escherichia	ygjK	GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716		ko:K03931					ko00000		GH63		Escherichia	1MXU9@1224,1RRDG@1236,3XMCX@561,COG1626@1,COG1626@2,COG3408@1,COG3408@2	NA|NA|NA	G	Glucoside hydrolase that cleaves the alpha-1,3- glucosidic linkage in nigerose. Has very low activity towards maltooligosaccharides, soluble starch, nigerotriose, kojibiose and trehalose
b3081	316407.85675881	0.0	1347.4	Escherichia	fadH	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008670,GO:0009056,GO:0009062,GO:0009987,GO:0010181,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0016628,GO:0019395,GO:0019752,GO:0030258,GO:0032553,GO:0032787,GO:0033542,GO:0033543,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071949,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575	1.3.1.34	ko:K00219					ko00000,ko01000				Escherichia	1MVE0@1224,1RNM8@1236,3XNUV@561,COG0446@1,COG0446@2,COG1902@1,COG1902@2	NA|NA|NA	C	Functions as an auxiliary enzyme in the beta-oxidation of unsaturated fatty acids with double bonds at even carbon positions. Catalyzes the NADPH-dependent reduction of the C4-C5 double bond of the acyl chain of 2,4-dienoyl-CoA to yield 2-trans- enoyl-CoA. Acts on both isomers, 2-trans,4-cis- and 2-trans,4-trans-decadienoyl-CoA, with almost equal efficiency. Is not active with NADH instead of NADPH. Does not show cis- trans isomerase activity
b3082	198214.SF3122	3e-69	267.7	Gammaproteobacteria													Escherichia	1RBYR@1224,1S260@1236,COG5499@1,COG5499@2	NA|NA|NA	K	transcriptional regulator
b3083	155864.EDL933_4305	1.3e-53	215.3	Escherichia	higB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0043170,GO:0043487,GO:0043488,GO:0044237,GO:0044238,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0061013,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1903311,GO:2000112,GO:2000113		ko:K19166					ko00000,ko01000,ko02048				Escherichia	1N1N1@1224,1S932@1236,3XRAB@561,COG4680@1,COG4680@2	NA|NA|NA	J	this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics
b3084	316407.85675884	7.9e-221	772.7	Escherichia	rlmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052916,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.174	ko:K11391			R07234	RC00003	ko00000,ko01000,ko03009				Escherichia	1NEMR@1224,1RMXE@1236,3XMGF@561,COG2813@1,COG2813@2	NA|NA|NA	J	Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA
b3085	316407.85675885	5.2e-92	343.6	Escherichia	ygjP			ko:K07043					ko00000				Escherichia	1RDJ9@1224,1S45M@1236,3XNWK@561,COG1451@1,COG1451@2	NA|NA|NA	S	Specifically catalyzes the hydrolysis of UTP to UMP and diphosphate in vitro, albeit at apparently slow rate. Shows no activity towards ATP, GTP, CTP, dTTP and ITP as substrates
b3086	316407.85675886	6.9e-127	459.9	Escherichia	ygjQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944											Escherichia	1R5Q2@1224,1RZK7@1236,3XQJ9@561,COG2949@1,COG2949@2	NA|NA|NA	S	DUF218 domain
b3087	316407.85675887	8.2e-182	642.9	Escherichia	ygjR												Escherichia	1MZIG@1224,1RS5T@1236,3XM6C@561,COG0673@1,COG0673@2	NA|NA|NA	S	oxidoreductase activity
b3088	316407.85675888	4e-173	614.0	Escherichia	alx	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MUNR@1224,1RP9Y@1236,3XN6B@561,COG0861@1,COG0861@2	NA|NA|NA	P	Has been proposed to be a redox modulator
b3089	155864.EDL933_4311	1.6e-219	768.5	Escherichia	sstT	GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005295,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015175,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032329,GO:0034220,GO:0035725,GO:0044425,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039		ko:K07862					ko00000,ko02000	2.A.23.4		iAF1260.b3089,iBWG_1329.BWG_2799,iECDH10B_1368.ECDH10B_3265,iECDH1ME8569_1439.ECDH1ME8569_2984,iECH74115_1262.ECH74115_4404,iECIAI1_1343.ECIAI1_3235,iECO103_1326.ECO103_3834,iECO111_1330.ECO111_3911,iECO26_1355.ECO26_4192,iECP_1309.ECP_3180,iECSE_1348.ECSE_3370,iECSP_1301.ECSP_4063,iECUMN_1333.ECUMN_3573,iECW_1372.ECW_m3356,iECs_1301.ECs3971,iEKO11_1354.EKO11_0630,iETEC_1333.ETEC_3359,iEcDH1_1363.EcDH1_0612,iEcE24377_1341.EcE24377A_3557,iG2583_1286.G2583_3813,iJO1366.b3089,iJR904.b3089,iSFV_1184.SFV_3130,iSSON_1240.SSON_3242,iUMNK88_1353.UMNK88_3845,iWFL_1372.ECW_m3356,iY75_1357.Y75_RS16050,iZ_1308.Z4442	Escherichia	1MXE1@1224,1RP9B@1236,3XM7S@561,COG3633@1,COG3633@2	NA|NA|NA	E	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
b3090	316407.85675890	8e-102	376.3	Escherichia	ygjV	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Escherichia	1RJV0@1224,1T13I@1236,28NVI@1,2ZBTK@2,3XRMQ@561	NA|NA|NA	S	Bacterial inner membrane protein
b3091	316407.85675891	6.6e-292	1009.2	Escherichia	uxaA	GO:0003674,GO:0005488,GO:0005506,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0008198,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0046872,GO:0046914,GO:0071704,GO:0072329,GO:1901575	4.2.1.7	ko:K01685	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_3836	Escherichia	1MU9V@1224,1RP0M@1236,3XMJR@561,COG2721@1,COG2721@2	NA|NA|NA	G	altronate dehydratase activity
b3092	198214.SF3132	3.1e-283	980.3	Gammaproteobacteria													Escherichia	1MVRI@1224,1RMRR@1236,COG1904@1,COG1904@2	NA|NA|NA	G	glucuronate isomerase
b3093	155864.EDL933_4315	7.9e-241	839.3	Escherichia	exuT	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015133,GO:0015134,GO:0015144,GO:0015145,GO:0015318,GO:0015711,GO:0015718,GO:0015735,GO:0015736,GO:0015749,GO:0015778,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0034220,GO:0044425,GO:0044464,GO:0046942,GO:0046943,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K08191					ko00000,ko02000	2.A.1.14.2		iBWG_1329.BWG_2803,iEC55989_1330.EC55989_3507,iECDH10B_1368.ECDH10B_3269,iECDH1ME8569_1439.ECDH1ME8569_2988,iECIAI39_1322.ECIAI39_3590,iECSP_1301.ECSP_4067,iECs_1301.ECs3975,iETEC_1333.ETEC_3363,iG2583_1286.G2583_3817,iZ_1308.Z4446	Escherichia	1MV04@1224,1RP70@1236,3XNJH@561,COG2271@1,COG2271@2	NA|NA|NA	P	Hexuronate transporter
b3094	155864.EDL933_4316	3.7e-145	520.8	Escherichia	exuR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K19775					ko00000,ko03000				Escherichia	1MY44@1224,1RN58@1236,3XM90@561,COG2186@1,COG2186@2	NA|NA|NA	K	Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers
b3095	155864.EDL933_4318	1.1e-118	432.6	Escherichia	yqjA	GO:0000003,GO:0000910,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022857,GO:0032505,GO:0043093,GO:0044464,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0071944											Escherichia	1MU30@1224,1RNS5@1236,3XPA0@561,COG0586@1,COG0586@2	NA|NA|NA	S	Inner membrane protein YqjA
b3096	316407.85675896	1.7e-66	258.5	Escherichia	mzrA	GO:0001932,GO:0008150,GO:0019220,GO:0019222,GO:0031323,GO:0031399,GO:0032268,GO:0042325,GO:0043549,GO:0045859,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051174,GO:0051246,GO:0051338,GO:0060255,GO:0065007,GO:0065009,GO:0080090											Escherichia	1RFWN@1224,1S4DF@1236,2E956@1,333DY@2,3XPRQ@561	NA|NA|NA	S	Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR
b3097	155864.EDL933_4320	3.2e-46	191.0	Escherichia	yqjC												Escherichia	1NAAB@1224,1SE1J@1236,3XPQR@561,COG1422@1,COG1422@2	NA|NA|NA	S	Protein of unknown function (DUF1090)
b3098	155864.EDL933_4321	1.1e-44	185.7	Escherichia	yqjD	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0043021,GO:0043024,GO:0044464,GO:0044877,GO:0060187,GO:0071944											Escherichia	1N6X7@1224,1S9QF@1236,3XPV7@561,COG4575@1,COG4575@2	NA|NA|NA	S	ribosome binding
b3099	155864.EDL933_4322	1.3e-61	242.3	Escherichia	yqjE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RHS9@1224,1S5UU@1236,3XPK8@561,COG5393@1,COG5393@2	NA|NA|NA	S	Putative Actinobacterial Holin-X, holin superfamily III
b3100	316407.85675900	3.6e-48	197.2	Escherichia	yqjK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N7E9@1224,1SCW7@1236,2E52J@1,32ZVT@2,3XPY4@561	NA|NA|NA	S	YqjK-like protein
b3101	155864.EDL933_4324	3.2e-65	254.2	Escherichia	yqjF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K15977					ko00000				Escherichia	1MZVP@1224,1S8UI@1236,3XPNK@561,COG2259@1,COG2259@2	NA|NA|NA	S	DoxX
b3102	316407.85675902	3e-200	704.1	Escherichia	yqjG	GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0044424,GO:0044464,GO:0055114	1.8.5.7	ko:K07393					ko00000,ko01000			iECW_1372.ECW_m3373,iWFL_1372.ECW_m3373	Escherichia	1MV50@1224,1RMTI@1236,3XNCT@561,COG0435@1,COG0435@2	NA|NA|NA	O	Catalyzes glutathione (GSH)-dependent reduction of glutathionyl-hydroquinones (GS-HQs) to the corresponding hydroquinones. Can use a variety of GS-HQs as substrates, such as GS-p-hydroquinone (GS-HQ), GS-hydroxy-p-hydroquinone (GS-HHQ), GS- methyl-p-hydroquinone (GS-MHQ), GS-menadiol, and GS-trichloro-p- hydroquinone (GS-TriCH). Also displays GSH-dependent disulfide- bond reduction activity toward HED (2-hydroxyethyl disulfide), and is able to catalyze DMA (dimethylarsinate) reduction. Exhibits no GSH transferase activity with 1-chloro-2,4-dinitrobenzene (CDNB)
b3103	155864.EDL933_4326	4.5e-69	266.9	Escherichia	yhaH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MZJ4@1224,1SA1N@1236,3XPKE@561,COG3152@1,COG3152@2	NA|NA|NA	S	Protein of unknown function (DUF805)
b3104	155864.EDL933_4327	2.2e-60	238.0	Escherichia	yhaI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MZJ4@1224,1SA1N@1236,3XPKE@561,COG3152@1,COG3152@2	NA|NA|NA	S	Protein of unknown function (DUF805)
b3105	155864.EDL933_4328	5.9e-163	580.1	Escherichia	yhaJ	GO:0001130,GO:0001216,GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141											Escherichia	1MZTA@1224,1RN7R@1236,3XMMI@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
b3106	316407.85675906	7.2e-132	476.5	Escherichia	yhaK			ko:K06911					ko00000				Escherichia	1MWSY@1224,1RMSK@1236,3XMRG@561,COG1741@1,COG1741@2	NA|NA|NA	S	Belongs to the pirin family
b3107	316407.85675907	5.6e-19	99.4	Escherichia	yhaL												Escherichia	1NIFB@1224,1SGPP@1236,2EMRY@1,33FED@2,3XQ3G@561	NA|NA|NA		
b4470	316407.85675908	5.3e-237	826.6	Escherichia	yhaM	GO:0000096,GO:0000098,GO:0001101,GO:0003674,GO:0003824,GO:0006082,GO:0006090,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009987,GO:0010033,GO:0010243,GO:0016054,GO:0016829,GO:0016846,GO:0019448,GO:0019450,GO:0019752,GO:0032787,GO:0042221,GO:0043200,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0046395,GO:0046439,GO:0050896,GO:0071704,GO:0080146,GO:1901367,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700											Escherichia	1MW81@1224,1RP1R@1236,3XNM0@561,COG3681@1,COG3681@2	NA|NA|NA	S	UPF0597 protein YhaM
b3110	511145.b3110	6.2e-241	839.7	Escherichia	yhaO	GO:0000096,GO:0000098,GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009987,GO:0010033,GO:0010243,GO:0015711,GO:0015804,GO:0015849,GO:0015893,GO:0016020,GO:0016054,GO:0019752,GO:0032329,GO:0042221,GO:0042493,GO:0042940,GO:0042942,GO:0043200,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:1901367,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700											Escherichia	1N3PB@1224,1RQXP@1236,3XM8X@561,COG0814@1,COG0814@2	NA|NA|NA	E	Plays a role in L-cysteine detoxification. May transport both D- and L-serine (By similarity)
b4471	316407.85675910	3.6e-260	903.7	Escherichia	tdcG	GO:0003674,GO:0003824,GO:0003941,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230		R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000			iECSP_1301.ECSP_4084	Escherichia	1MUZN@1224,1RMJZ@1236,3XNG8@561,COG1760@1,COG1760@2	NA|NA|NA	E	L-serine ammonia-lyase activity
b3113	155864.EDL933_4334	9.4e-65	252.7	Escherichia	tdcF	GO:0003674,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	3.5.99.10	ko:K09022			R11098,R11099	RC03275,RC03354	ko00000,ko01000				Escherichia	1MZ3J@1224,1S5XS@1236,3XPIQ@561,COG0251@1,COG0251@2	NA|NA|NA	E	May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2-ketobutyrate
b3114	316407.85675912	0.0	1545.4	Escherichia	tdcE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006629,GO:0006631,GO:0006807,GO:0008150,GO:0008152,GO:0008861,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016020,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017144,GO:0019541,GO:0019752,GO:0032787,GO:0042737,GO:0043436,GO:0043875,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046459,GO:0070689,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120		R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000			iEcSMS35_1347.EcSMS35_3410	Escherichia	1MWYE@1224,1RWKK@1236,3XMIN@561,COG1882@1,COG1882@2	NA|NA|NA	C	formate acetyltransferase
b3115	469008.B21_02933	7.8e-227	792.7	Escherichia	tdcD	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006113,GO:0006520,GO:0006566,GO:0006567,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008776,GO:0008980,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0015980,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019665,GO:0019666,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.15	ko:K00932	ko00640,ko01100,map00640,map01100		R01353	RC00002,RC00043	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_3309,iECS88_1305.ECS88_3508,iEcSMS35_1347.EcSMS35_3411,iLF82_1304.LF82_2233,iUTI89_1310.UTI89_C3550	Escherichia	1MW61@1224,1RMKB@1236,3XPDE@561,COG0282@1,COG0282@2	NA|NA|NA	F	Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP
b3116	155864.EDL933_4337	8.6e-243	845.9	Escherichia	tdcC	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015078,GO:0015171,GO:0015175,GO:0015179,GO:0015194,GO:0015195,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015711,GO:0015804,GO:0015807,GO:0015825,GO:0015826,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022889,GO:0022890,GO:0031224,GO:0031226,GO:0032329,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902475,GO:1902600,GO:1903825,GO:1905039		ko:K03838					ko00000,ko02000	2.A.42.2.2		iAPECO1_1312.APECO1_3308,iE2348C_1286.E2348C_3406,iEC55989_1330.EC55989_3533,iECABU_c1320.ECABU_c35330,iECED1_1282.ECED1_3781,iECIAI1_1343.ECIAI1_3265,iECNA114_1301.ECNA114_4343,iECO103_1326.ECO103_3863,iECO26_1355.ECO26_4221,iECOK1_1307.ECOK1_3543,iECP_1309.ECP_3209,iECSE_1348.ECSE_3400,iECSF_1327.ECSF_2956,iECW_1372.ECW_m3385,iEKO11_1354.EKO11_0601,iLF82_1304.LF82_2232,iNRG857_1313.NRG857_15495,iSBO_1134.SBO_2981,iSbBS512_1146.SbBS512_E3241,iUMN146_1321.UM146_00750,iUTI89_1310.UTI89_C3551,iWFL_1372.ECW_m3385,ic_1306.c3874	Escherichia	1QB56@1224,1RMJ8@1236,3XP6Z@561,COG0814@1,COG0814@2	NA|NA|NA	E	Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system)
b3117	155864.EDL933_4338	1.3e-182	645.6	Escherichia	tdcB	GO:0003674,GO:0003824,GO:0003941,GO:0004793,GO:0004794,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006565,GO:0006566,GO:0006567,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016597,GO:0016829,GO:0016830,GO:0016832,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000				Escherichia	1MVWJ@1224,1RPGU@1236,3XMXP@561,COG1171@1,COG1171@2	NA|NA|NA	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
b3118	155864.EDL933_4339	4.4e-169	600.5	Escherichia	tdcA	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K07592					ko00000,ko03000				Escherichia	1R6CD@1224,1RSEB@1236,3XNVP@561,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
b3119	155864.EDL933_4340	4.5e-32	143.3	Gammaproteobacteria													Escherichia	1NUBP@1224,1SN6K@1236,2F0UD@1,33TWB@2	NA|NA|NA		
b3124	316407.85675921	5.7e-211	740.0	Escherichia	garK	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0043798,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130		R08572	RC00002,RC00428	ko00000,ko00001,ko01000			iECs_1301.ECs4002,iG2583_1286.G2583_3846	Escherichia	1MVG9@1224,1RMC6@1236,3XMJD@561,COG1929@1,COG1929@2	NA|NA|NA	G	Belongs to the glycerate kinase type-1 family
b3125	155864.EDL933_4344	3.7e-157	560.8	Escherichia	garR	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100		R01745,R01747	RC00099	ko00000,ko00001,ko01000			iNRG857_1313.NRG857_15520	Escherichia	1MUGU@1224,1SYGG@1236,3XP63@561,COG2084@1,COG2084@2	NA|NA|NA	I	Catalyzes the reduction of tatronate semialdehyde to D- glycerate
b3126	316407.85675923	5e-142	510.4	Escherichia	garL	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008672,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046392,GO:0046395,GO:0071704,GO:1901575	4.1.2.20	ko:K01630	ko00053,map00053		R02754,R03277	RC00307,RC00435	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_3301,iE2348C_1286.E2348C_3412,iEC042_1314.EC042_3416,iEC55989_1330.EC55989_3544,iECIAI1_1343.ECIAI1_3274,iECIAI39_1322.ECIAI39_3625,iECNA114_1301.ECNA114_3207,iECO103_1326.ECO103_3871,iECO26_1355.ECO26_4229,iECOK1_1307.ECOK1_3549,iECP_1309.ECP_3216,iECS88_1305.ECS88_3514,iECSE_1348.ECSE_3410,iECSF_1327.ECSF_2962,iECUMN_1333.ECUMN_3608,iECW_1372.ECW_m3394,iECs_1301.ECs4004,iEKO11_1354.EKO11_0593,iEcE24377_1341.EcE24377A_3604,iEcSMS35_1347.EcSMS35_3421,iG2583_1286.G2583_3848,iLF82_1304.LF82_0805,iNRG857_1313.NRG857_15525,iSBO_1134.SBO_2991,iUMN146_1321.UM146_00720,iUTI89_1310.UTI89_C3557,iWFL_1372.ECW_m3394,iZ_1308.Z4478	Escherichia	1MUSG@1224,1RMWJ@1236,3XMGU@561,COG3836@1,COG3836@2	NA|NA|NA	G	Catalyzes the reversible retro-aldol cleavage of both 5- keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde
b3127	155864.EDL933_4346	2.5e-250	870.9	Escherichia	garP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K12299					ko00000,ko02000	2.A.1.14.14		iSF_1195.SF3164,iSFxv_1172.SFxv_3474,iS_1188.S3379	Escherichia	1MVPS@1224,1RNMV@1236,3XNY3@561,COG2271@1,COG2271@2	NA|NA|NA	P	galactarate transporter
b3128	316407.85675925	2.4e-284	984.2	Escherichia	garD	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008867,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0071704,GO:1901575	4.2.1.42	ko:K01708	ko00053,map00053		R05608	RC00543	ko00000,ko00001,ko01000			iECED1_1282.ECED1_3790,iECP_1309.ECP_3218,iLF82_1304.LF82_0803,iNRG857_1313.NRG857_15535	Escherichia	1MU9V@1224,1RP0M@1236,3XMT0@561,COG2721@1,COG2721@2	NA|NA|NA	E	Catalyzes the dehydration of galactarate to form 5- dehydro-4-deoxy-D-glucarate
b3129	316407.85675926	3.6e-57	227.3	Escherichia	sohA	GO:0001558,GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0040008,GO:0042802,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K19156					ko00000,ko02048				Escherichia	1RIAX@1224,1SC9R@1236,3XRA1@561,COG2002@1,COG2002@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the YhaV toxin and neutralizes its ribonuclease activity. Also acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
b3130	155864.EDL933_4350	8e-87	326.2	Escherichia	yhaV	GO:0001558,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0030308,GO:0034641,GO:0040008,GO:0043021,GO:0043023,GO:0043170,GO:0044237,GO:0044238,GO:0044877,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360		ko:K19155					ko00000,ko01000,ko02048				Escherichia	1Q4H5@1224,1S3G4@1236,28N0M@1,2ZB6Z@2,3XQ7U@561	NA|NA|NA	K	acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression
b3131	155864.EDL933_4351	2.1e-143	515.0	Escherichia	agaR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K02081					ko00000,ko03000				Escherichia	1MUJT@1224,1SZXU@1236,3XPHU@561,COG1349@1,COG1349@2	NA|NA|NA	K	repressor for the aga operon for N-acetyl galactosamine transport and metabolism
b3132	316407.85675929	7.7e-249	865.9	Escherichia	kbaZ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K16371	ko00052,ko01100,map00052,map01100		R01069	RC00438,RC00439	ko00000,ko00001			iECIAI1_1343.ECIAI1_3280	Escherichia	1MW3Q@1224,1RQAU@1236,3XNDM@561,COG4573@1,COG4573@2	NA|NA|NA	G	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
b3133	316407.85675930	1.9e-83	315.1	Escherichia	agaV			ko:K02745	ko00052,ko02060,map00052,map02060	M00277	R08366	RC00017	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1.4		iECH74115_1262.ECH74115_4447,iECSP_1301.ECSP_4104	Escherichia	1R4ES@1224,1RQ2P@1236,3XNQ1@561,COG3444@1,COG3444@2	NA|NA|NA	G	IIB component
b3134	1440052.EAKF1_ch2805c	7.2e-44	183.3	Escherichia	agaW			ko:K02746	ko00052,ko02060,map00052,map02060	M00277	R08366	RC00017	ko00000,ko00001,ko00002,ko02000	4.A.6.1.4		ic_1306.c3889	Escherichia	1NBYA@1224,1RQ1Z@1236,3XNP9@561,COG3715@1,COG3715@2	NA|NA|NA	G	PTS system sorbose-specific iic component
b3135	155864.EDL933_4357	9.6e-86	322.8	Escherichia	agaA		3.5.1.25	ko:K02079	ko00052,map00052		R05168	RC00166,RC00300	ko00000,ko00001,ko01000			iECBD_1354.ECBD_0605,iECB_1328.ECB_03002,iECD_1391.ECD_03002	Escherichia	1MW8Y@1224,1RMRV@1236,3XQ91@561,COG1820@1,COG1820@2	NA|NA|NA	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family
b3136	316407.85675932	2.1e-221	774.6	Escherichia	agaS	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006044,GO:0006046,GO:0006810,GO:0008150,GO:0008152,GO:0008448,GO:0008643,GO:0009056,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071944,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575		ko:K02082					ko00000,ko01000				Escherichia	1NICK@1224,1RRU0@1236,3XPES@561,COG2222@1,COG2222@2	NA|NA|NA	G	Catalyzes the isomerization-deamination of galactosamine 6-phosphate to form tagatofuranose 6-phosphate and ammonium ion
b3137	155864.EDL933_4360	1.2e-160	572.4	Escherichia	kbaY	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009025,GO:0009987,GO:0016043,GO:0016829,GO:0016830,GO:0016832,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071840	4.1.2.40	ko:K08302	ko00052,ko01100,map00052,map01100		R01069	RC00438,RC00439	ko00000,ko00001,ko01000			iAF1260.b3137,iAPECO1_1312.APECO1_3290,iB21_1397.B21_02955,iBWG_1329.BWG_2841,iEC042_1314.EC042_3431,iEC55989_1330.EC55989_3557,iECABU_c1320.ECABU_c35530,iECBD_1354.ECBD_0603,iECB_1328.ECB_03004,iECDH10B_1368.ECDH10B_3310,iECDH1ME8569_1439.ECDH1ME8569_3028,iECD_1391.ECD_03004,iECED1_1282.ECED1_3801,iECH74115_1262.ECH74115_4454,iECIAI1_1343.ECIAI1_3287,iECO103_1326.ECO103_3884,iECO111_1330.ECO111_3961,iECO26_1355.ECO26_4242,iECOK1_1307.ECOK1_3561,iECP_1309.ECP_3229,iECS88_1305.ECS88_3525,iECSE_1348.ECSE_3423,iECSP_1301.ECSP_4111,iECW_1372.ECW_m3407,iECs_1301.ECs4017,iEKO11_1354.EKO11_0580,iETEC_1333.ETEC_3404,iEcDH1_1363.EcDH1_0568,iEcE24377_1341.EcE24377A_3619,iEcHS_1320.EcHS_A3329,iEcolC_1368.EcolC_0561,iG2583_1286.G2583_2628,iG2583_1286.G2583_3861,iJO1366.b3137,iJR904.b3137,iLF82_1304.LF82_1138,iNRG857_1313.NRG857_15590,iUMN146_1321.UM146_00665,iUMNK88_1353.UMNK88_3896,iUTI89_1310.UTI89_C3568,iWFL_1372.ECW_m3407,iY75_1357.Y75_RS16275,iZ_1308.Z4491,ic_1306.c3894	Escherichia	1MURX@1224,1RQUC@1236,3XPA4@561,COG0191@1,COG0191@2	NA|NA|NA	F	which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6- bisphosphate (TBP). Requires
b3138	316407.85675934	2.2e-84	318.2	Escherichia	agaB			ko:K10984	ko00052,ko02060,map00052,map02060	M00287	R08367	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1.5		iB21_1397.B21_02956,iEC55989_1330.EC55989_3558,iECBD_1354.ECBD_0602,iECB_1328.ECB_03005,iECD_1391.ECD_03005,iECIAI1_1343.ECIAI1_3288,iECIAI39_1322.ECIAI39_3639,iECO103_1326.ECO103_3885,iECO111_1330.ECO111_3962,iECO26_1355.ECO26_4243,iECSE_1348.ECSE_3424,iECW_1372.ECW_m3408,iEKO11_1354.EKO11_0579,iEcE24377_1341.EcE24377A_3620,iEcSMS35_1347.EcSMS35_3437,iEcolC_1368.EcolC_0560,iUMNK88_1353.UMNK88_3897,iWFL_1372.ECW_m3408	Escherichia	1R4ES@1224,1RWA2@1236,3XMC9@561,COG3444@1,COG3444@2	NA|NA|NA	G	IIB component
b3139	316407.85675935	1.2e-141	509.2	Escherichia	agaC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K10985	ko00052,ko02060,map00052,map02060	M00287	R08367	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1.5			Escherichia	1R5G0@1224,1RZTN@1236,3XPEE@561,COG3715@1,COG3715@2	NA|NA|NA	G	PTS system N-acetylgalactosamine-specific
b3140	316407.85675936	7.9e-143	513.1	Escherichia	agaD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K10986	ko00052,ko02060,map00052,map02060	M00287	R08367	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1.5		iUTI89_1310.UTI89_C3571,ic_1306.c3897	Escherichia	1R44X@1224,1RZ59@1236,3XMX9@561,COG3716@1,COG3716@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport
b3141	316407.85675937	2.9e-139	501.1	Escherichia	agaI	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016853,GO:0016860,GO:0016861,GO:0043877,GO:0044424,GO:0044444,GO:0044464		ko:K02080	ko00052,map00052		R08365	RC00163	ko00000,ko00001,ko01000			iB21_1397.B21_02959,iECB_1328.ECB_03008,iECD_1391.ECD_03008,iECNA114_1301.ECNA114_3225,iECSF_1327.ECSF_2979	Escherichia	1R8UH@1224,1RY0A@1236,3XNZ8@561,COG0363@1,COG0363@2	NA|NA|NA	G	galactosamine-6-phosphate isomerase activity
b3142	316407.85675938	8.7e-107	392.9	Escherichia	yraH	GO:0007155,GO:0008150,GO:0022610											Escherichia	1N34A@1224,1SBGF@1236,3XRDH@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon
b3143	316407.85675939	5.7e-129	466.8	Escherichia	yraI												Escherichia	1PJPH@1224,1RYC4@1236,3XR1M@561,COG3121@1,COG3121@2	NA|NA|NA	M	Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon
b3144	316407.85675940	0.0	1680.6	Escherichia	yraJ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071840,GO:0071944		ko:K07347	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Escherichia	1MUHE@1224,1RMPU@1236,3XQDY@561,COG3188@1,COG3188@2	NA|NA|NA	NU	Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon. Probably involved in the export and assembly of fimbrial subunits across the outer membrane
b3145	316407.85675941	6.2e-207	726.5	Gammaproteobacteria													Escherichia	1R6S6@1224,1S0U1@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon
b3146	1440052.EAKF1_ch2791	6.1e-157	560.1	Escherichia	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056					ko00000,ko01000,ko03009				Escherichia	1MU0E@1224,1RM7U@1236,3XP22@561,COG0313@1,COG0313@2	NA|NA|NA	J	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
b3147	316407.85675943	0.0	1265.0	Escherichia	lpoA	GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576		ko:K07121					ko00000				Escherichia	1MUHR@1224,1RXX4@1236,3XMC3@561,COG3107@1,COG3107@2	NA|NA|NA	M	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a)
b3148	316407.85675944	1.7e-69	268.5	Escherichia	yraN			ko:K07460					ko00000				Escherichia	1N6VN@1224,1SC8A@1236,3XPNC@561,COG0792@1,COG0792@2	NA|NA|NA	L	Belongs to the UPF0102 family
b3149	1440052.EAKF1_ch2788c	1.2e-103	382.5	Escherichia	diaA	GO:0003674,GO:0005488,GO:0005515,GO:0006275,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0042802,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0065007,GO:0080090,GO:0090329,GO:2000105,GO:2000112		ko:K12961					ko00000,ko03036				Escherichia	1NJ8X@1224,1RS1Y@1236,3XMII@561,COG0279@1,COG0279@2	NA|NA|NA	J	Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein
b3150	155864.EDL933_4377	4.4e-87	327.4	Escherichia	yraP	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0044462,GO:0044464,GO:0071944											Escherichia	1MUZ2@1224,1RY2B@1236,3XNV6@561,COG2823@1,COG2823@2	NA|NA|NA	S	BON domain
b3151	316407.85675947	4.6e-191	673.7	Escherichia	yraQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07089					ko00000				Escherichia	1MUN8@1224,1RR9N@1236,3XMSV@561,COG0701@1,COG0701@2	NA|NA|NA	S	Predicted permease
b3152	316407.85675948	2.3e-116	424.9	Escherichia	yraR												Escherichia	1MZG7@1224,1S39N@1236,3XNI7@561,COG0702@1,COG0702@2	NA|NA|NA	GM	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
b3153	155864.EDL933_4380	1.2e-91	342.4	Escherichia	yhbO	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0006139,GO:0006259,GO:0006281,GO:0006464,GO:0006517,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009100,GO:0009266,GO:0009268,GO:0009314,GO:0009408,GO:0009411,GO:0009416,GO:0009438,GO:0009628,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019249,GO:0019538,GO:0019752,GO:0030091,GO:0032787,GO:0033554,GO:0034641,GO:0036211,GO:0036524,GO:0036525,GO:0042180,GO:0042182,GO:0042802,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046394,GO:0046483,GO:0050896,GO:0051596,GO:0051716,GO:0061727,GO:0071704,GO:0072330,GO:0090304,GO:0140096,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901617	3.5.1.124	ko:K05520					ko00000,ko01000,ko01002				Escherichia	1MY0C@1224,1S3SC@1236,3XN80@561,COG0693@1,COG0693@2	NA|NA|NA	S	Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, collagen, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. In vitro, prevents acrylamide formation in asparagine glyoxal and asparagine sugar mixtures at 55 degrees Celsius, likely by degrading asparagine glyoxal Maillard adducts formed at high temperatures. Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity. Is a general stress protein
b3154	198214.SF3195	6.9e-80	303.1	Gammaproteobacteria													Escherichia	1RH76@1224,1S6F1@1236,COG3787@1,COG3787@2	NA|NA|NA	S	Belongs to the UPF0306 family
b3155	316407.85675951	3.6e-48	197.2	Escherichia	yhbQ	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360		ko:K07461					ko00000				Escherichia	1N6PA@1224,1SCBH@1236,3XPY2@561,COG2827@1,COG2827@2	NA|NA|NA	L	Belongs to the UPF0213 family
b3156	155864.EDL933_4383	4e-92	344.0	Escherichia	yhbS	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564		ko:K03824					ko00000,ko01000				Escherichia	1RA42@1224,1S2G0@1236,3XP7J@561,COG3153@1,COG3153@2	NA|NA|NA	S	transferase activity, transferring acyl groups
b3157	199310.c3910	1.8e-90	338.6	Escherichia	yhbT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1RB7T@1224,1RMJD@1236,3XMBQ@561,COG3154@1,COG3154@2	NA|NA|NA	I	SCP-2 sterol transfer family
b3158	316407.85675954	1.7e-190	671.8	Escherichia	yhbU			ko:K08303	ko05120,map05120				ko00000,ko00001,ko01000,ko01002				Escherichia	1MUQG@1224,1RP6X@1236,3XN96@561,COG0826@1,COG0826@2	NA|NA|NA	O	peptidase activity
b3159	316407.85675955	3.5e-168	597.4	Escherichia	yhbV												Escherichia	1MWFW@1224,1RMWM@1236,3XMXE@561,COG0826@1,COG0826@2	NA|NA|NA	O	peptidase activity
b3160	199310.c3913	8.9e-192	676.0	Escherichia	yhbW	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MVF0@1224,1RMCE@1236,3XM8W@561,COG2141@1,COG2141@2	NA|NA|NA	C	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
b3161	198214.SF3202	5.6e-228	796.6	Gammaproteobacteria													Escherichia	1MWGI@1224,1RMME@1236,COG0814@1,COG0814@2	NA|NA|NA	E	amino acid
b3162	155864.EDL933_4391	3.1e-286	990.7	Escherichia	deaD	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0033554,GO:0033592,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112	3.6.4.13	ko:K05592	ko03018,map03018				ko00000,ko00001,ko01000,ko03009,ko03019				Escherichia	1MU49@1224,1RMWA@1236,3XNGY@561,COG0513@1,COG0513@2	NA|NA|NA	F	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation
b3163	155864.EDL933_4392	2.8e-165	587.8	Escherichia	nlpI	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009987,GO:0016020,GO:0030674,GO:0044464,GO:0051301,GO:0060090,GO:0071944		ko:K05803					ko00000				Escherichia	1N02Y@1224,1RP8P@1236,3XNGQ@561,COG4785@1,COG4785@2	NA|NA|NA	D	May be involved in cell division. May play a role in bacterial septation or regulation of cell wall degradation during cell division
b3164	316407.85675960	0.0	1357.4	Escherichia	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019				Escherichia	1MVB9@1224,1RNBF@1236,3XN31@561,COG1185@1,COG1185@2	NA|NA|NA	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
b3165	198214.SF3206	2.5e-40	171.0	Gammaproteobacteria													Escherichia	1MZ2W@1224,1S8U6@1236,COG0184@1,COG0184@2	NA|NA|NA	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
b3166	155864.EDL933_4395	9.9e-177	625.9	Escherichia	truB	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481	5.4.99.25	ko:K03177					ko00000,ko01000,ko03016				Escherichia	1MV0N@1224,1RMKP@1236,3XME1@561,COG0130@1,COG0130@2	NA|NA|NA	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
b3167	155864.EDL933_4396	2.5e-65	254.6	Escherichia	rbfA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360		ko:K02834					ko00000,ko03009				Escherichia	1MZPE@1224,1S9AF@1236,3XPJJ@561,COG0858@1,COG0858@2	NA|NA|NA	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
b3168	155864.EDL933_4397	0.0	1416.7	Escherichia	infB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02519					ko00000,ko03012,ko03029				Escherichia	1MV26@1224,1RM9X@1236,3XMNK@561,COG0532@1,COG0532@2	NA|NA|NA	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
b3169	155864.EDL933_4398	4e-273	946.8	Escherichia	nusA	GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02600					ko00000,ko03009,ko03021				Escherichia	1MWT7@1224,1RNQS@1236,3XP77@561,COG0195@1,COG0195@2	NA|NA|NA	K	Participates in both transcription termination and antitermination
b3170	198214.SF3211	2.5e-77	294.7	Gammaproteobacteria													Escherichia	1RDP2@1224,1S3Y7@1236,COG0779@1,COG0779@2	NA|NA|NA	S	Required for maturation of 30S ribosomal subunits
b3172	199310.c3929	6.4e-262	909.4	Escherichia	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147			iSBO_1134.SBO_3210,iSbBS512_1146.SbBS512_E3599	Escherichia	1MV0Y@1224,1RMEC@1236,3XN1V@561,COG0137@1,COG0137@2	NA|NA|NA	F	Belongs to the argininosuccinate synthase family. Type 2 subfamily
b3173	316407.85675968	9.9e-310	1068.5	Escherichia	yhbX	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016776,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509											Escherichia	1MWS7@1224,1SYHV@1236,3XQZT@561,COG2194@1,COG2194@2	NA|NA|NA	S	sulfuric ester hydrolase activity
b3175	155864.EDL933_4403	4.7e-49	200.3	Escherichia	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680		ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Escherichia	1N8MF@1224,1SD3P@1236,3XPS3@561,COG1314@1,COG1314@2	NA|NA|NA	U	Preprotein translocase band 1 subunit
b3176	316407.85675970	1.5e-250	871.7	Escherichia	glmM	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130		R02060	RC00408	ko00000,ko00001,ko01000			iSBO_1134.SBO_3206	Escherichia	1MU24@1224,1RMR2@1236,3XNUN@561,COG1109@1,COG1109@2	NA|NA|NA	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
b3177	155864.EDL933_4405	3.6e-154	550.8	Escherichia	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_3924	Escherichia	1MUIR@1224,1RM8G@1236,3XM3V@561,COG0294@1,COG0294@2	NA|NA|NA	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
b3178	198214.SF3218	0.0	1261.9	Gammaproteobacteria													Escherichia	1MU6J@1224,1RME8@1236,COG0465@1,COG0465@2	NA|NA|NA	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
b3179	155864.EDL933_4407	1e-113	416.0	Escherichia	rlmE	GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.166	ko:K02427					ko00000,ko01000,ko03009				Escherichia	1MW1C@1224,1RN5M@1236,3XP2N@561,COG0293@1,COG0293@2	NA|NA|NA	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
b3180	155864.EDL933_4408	2.1e-45	188.0	Escherichia	yhbY	GO:0000027,GO:0000028,GO:0000966,GO:0000967,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0042274,GO:0043021,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1990275		ko:K07574					ko00000,ko03009				Escherichia	1N8K5@1224,1SDIM@1236,3XPVR@561,COG1534@1,COG1534@2	NA|NA|NA	J	preribosome binding
b3181	155864.EDL933_4409	6.7e-81	306.6	Escherichia	greA	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03624					ko00000,ko03021				Escherichia	1RCXW@1224,1S3UP@1236,3XMI4@561,COG0782@1,COG0782@2	NA|NA|NA	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
b3182	316407.85675976	1.8e-254	884.8	Escherichia	dacB	GO:0000003,GO:0000270,GO:0000910,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006508,GO:0006807,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009987,GO:0016043,GO:0016787,GO:0016998,GO:0017171,GO:0019538,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0032505,GO:0033218,GO:0033293,GO:0036094,GO:0042597,GO:0043093,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044464,GO:0045229,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:0140096,GO:1901135,GO:1901136,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901681	3.4.16.4	ko:K07259	ko00550,map00550				ko00000,ko00001,ko01000,ko01002,ko01011			iAPECO1_1312.APECO1_3250,iECOK1_1307.ECOK1_3603,iECS88_1305.ECS88_3564,iUMN146_1321.UM146_00470,iUTI89_1310.UTI89_C3615	Escherichia	1MW40@1224,1RP8V@1236,3XMT9@561,COG2027@1,COG2027@2	NA|NA|NA	M	D-alanyl-D-alanine carboxypeptidase
b3183	316407.85675977	4.8e-205	720.3	Escherichia	obg	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03979					ko00000,ko01000,ko03009				Escherichia	1MUGZ@1224,1RMFQ@1236,3XNNJ@561,COG0536@1,COG0536@2	NA|NA|NA	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
b3184	155864.EDL933_4412	1.8e-173	615.1	Escherichia	yhbE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1PGSE@1224,1RMZY@1236,3XP7W@561,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
b3185	1440052.EAKF1_ch2754	4e-40	170.2	Escherichia	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1902626,GO:1990904		ko:K02899	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1MZGH@1224,1S8R2@1236,3XPWZ@561,COG0211@1,COG0211@2	NA|NA|NA	J	Ribosomal L27 protein
b3186	1218086.BBNB01000015_gene2157	1.4e-50	205.3	Citrobacter													Escherichia	1MZEW@1224,1S5VB@1236,3WYFF@544,COG0261@1,COG0261@2	NA|NA|NA	J	This protein binds to 23S rRNA in the presence of protein L20
b3187	1440052.EAKF1_ch2752c	8.4e-179	632.9	Escherichia	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110		R09248	RC00279	ko00000,ko00001,ko01000,ko01006			ic_1306.c3945	Escherichia	1MUK6@1224,1RPR7@1236,3XP2Y@561,COG0142@1,COG0142@2	NA|NA|NA	H	Polyprenyl synthetase
b3188	155864.EDL933_4416	9.7e-48	195.7	Escherichia	sfsB	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K07724					ko00000,ko03000				Escherichia	1N8W7@1224,1S966@1236,3XPV4@561,COG3423@1,COG3423@2	NA|NA|NA	K	This protein is involved in positive regulation of the metabolism of sugars
b3189	198214.SF3229	1.6e-235	821.6	Gammaproteobacteria													Escherichia	1MUH7@1224,1RN91@1236,COG0766@1,COG0766@2	NA|NA|NA	M	Belongs to the EPSP synthase family. MurA subfamily
b3190	155864.EDL933_4418	1.4e-40	171.8	Escherichia	yrbA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540											Escherichia	1N1WJ@1224,1SCAR@1236,3XPX8@561,COG5007@1,COG5007@2	NA|NA|NA	K	Belongs to the BolA IbaG family
b3191	155864.EDL933_4419	3e-47	194.1	Escherichia	mlaB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716		ko:K07122	ko02010,map02010	M00210			ko00000,ko00001,ko00002,ko02000	3.A.1.27.3			Escherichia	1NGIE@1224,1SD2Q@1236,3XPX2@561,COG3113@1,COG3113@2	NA|NA|NA	S	Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
b3192	198214.SF3232	2.3e-113	414.8	Gammaproteobacteria													Escherichia	1NKFA@1224,1RNJW@1236,COG2854@1,COG2854@2	NA|NA|NA	Q	ABC-type transport system involved in resistance to organic solvents auxiliary component
b3193	155864.EDL933_4421	5.9e-97	360.1	Escherichia	mlaD	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008289,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043167,GO:0043168,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02067	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Escherichia	1NCUG@1224,1RQ0Y@1236,3XM4B@561,COG1463@1,COG1463@2	NA|NA|NA	Q	Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
b3194	155864.EDL933_4422	1.3e-134	485.7	Escherichia	mlaE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02066	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Escherichia	1MVPN@1224,1RM9H@1236,3XM51@561,COG0767@1,COG0767@2	NA|NA|NA	Q	Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
b3195	155864.EDL933_4423	4.4e-149	533.9	Escherichia	mlaF	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0008144,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K02065	ko02010,map02010	M00210,M00669,M00670			ko00000,ko00001,ko00002,ko02000	3.A.1.27			Escherichia	1MUSD@1224,1RMCJ@1236,3XN7D@561,COG1127@1,COG1127@2	NA|NA|NA	P	Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for energy coupling to the transport system
b3196	316407.85675990	1.3e-168	599.0	Escherichia	yrbG	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005262,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006816,GO:0006873,GO:0006874,GO:0006875,GO:0008150,GO:0008273,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015081,GO:0015085,GO:0015267,GO:0015291,GO:0015297,GO:0015298,GO:0015318,GO:0015368,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022803,GO:0022804,GO:0022821,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030955,GO:0031224,GO:0031226,GO:0031402,GO:0031420,GO:0034220,GO:0035725,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070588,GO:0070838,GO:0071804,GO:0071805,GO:0071944,GO:0072503,GO:0072507,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516		ko:K07301					ko00000,ko02000	2.A.19.5		iAPECO1_1312.APECO1_3239,iECABU_c1320.ECABU_c36110,iECNA114_1301.ECNA114_3275,iECOK1_1307.ECOK1_3617,iECS88_1305.ECS88_3578,iECSF_1327.ECSF_3028,iUMN146_1321.UM146_00400,iUTI89_1310.UTI89_C3632,ic_1306.c3956	Escherichia	1MU3R@1224,1RMRD@1236,3XMSD@561,COG0530@1,COG0530@2	NA|NA|NA	P	calcium:cation antiporter activity
b3197	316407.85675991	1.5e-183	648.7	Escherichia	kdsD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0019146,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046400,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005			iECH74115_1262.ECH74115_4519,iECSP_1301.ECSP_4172,iECs_1301.ECs4076,iSFV_1184.SFV_3227,iSFxv_1172.SFxv_3550,iZ_1308.Z4560	Escherichia	1MUXD@1224,1RMT9@1236,3XMJQ@561,COG0517@1,COG0517@2,COG0794@1,COG0794@2	NA|NA|NA	M	Involved in the biosynthesis of 3-deoxy-D-manno- octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs)
b3198	155864.EDL933_4426	3.4e-100	370.9	Escherichia	kdsC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019143,GO:0033692,GO:0034637,GO:0034645,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005			iECO26_1355.ECO26_4302	Escherichia	1RH85@1224,1S6D0@1236,3XMZT@561,COG1778@1,COG1778@2	NA|NA|NA	F	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
b3199	155864.EDL933_4427	9.2e-101	372.9	Escherichia	lptC	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0017089,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264		ko:K11719					ko00000,ko02000	1.B.42.1		iB21_1397.B21_03015,iECBD_1354.ECBD_0543,iECB_1328.ECB_03064,iECD_1391.ECD_03064	Escherichia	1RA1Y@1224,1SDZE@1236,3XN1W@561,COG3117@1,COG3117@2	NA|NA|NA	U	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA
b3200	155864.EDL933_4428	1.3e-96	359.0	Escherichia	lptA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0010876,GO:0015920,GO:0016020,GO:0017089,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044462,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264		ko:K09774					ko00000,ko02000	1.B.42.1		iB21_1397.B21_03016,iECBD_1354.ECBD_0542,iECB_1328.ECB_03065,iECD_1391.ECD_03065	Escherichia	1N776@1224,1RPM7@1236,3XNN8@561,COG1934@1,COG1934@2	NA|NA|NA	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
b3201	1440052.EAKF1_ch2738c	8.3e-131	473.0	Escherichia	lptB	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K06861	ko02010,map02010	M00320			ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1			Escherichia	1MU8M@1224,1RPW1@1236,3XNDU@561,COG1137@1,COG1137@2	NA|NA|NA	P	Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system
b3202	316407.85675996	3.7e-223	780.8	Escherichia	rpoN	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K03092	ko02020,ko05111,map02020,map05111				ko00000,ko00001,ko03021				Escherichia	1MW4V@1224,1RMY0@1236,3XN0B@561,COG1508@1,COG1508@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
b3203	155864.EDL933_4431	2.1e-45	188.0	Escherichia	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113		ko:K05808					ko00000,ko03009				Escherichia	1MZHW@1224,1S8U1@1236,3XPXC@561,COG1544@1,COG1544@2	NA|NA|NA	J	During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes
b3204	198214.SF3244	5.7e-83	313.5	Gammaproteobacteria													Escherichia	1RD0E@1224,1S668@1236,COG1762@1,COG1762@2	NA|NA|NA	G	PTS IIA-like nitrogen-regulatory protein PtsN
b3205	155864.EDL933_4433	4.2e-158	563.9	Escherichia	rapZ	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K06958					ko00000,ko03019				Escherichia	1MVX6@1224,1RNJX@1236,3XP0Y@561,COG1660@1,COG1660@2	NA|NA|NA	S	Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS
b3206	198214.SF3246	5e-41	173.3	Gammaproteobacteria													Escherichia	1N6RM@1224,1SCXX@1236,COG1925@1,COG1925@2	NA|NA|NA	G	Phosphotransferase System
b3207	198214.SF3247	8.3e-111	406.4	Gammaproteobacteria													Escherichia	1RI1C@1224,1RNN5@1236,COG0515@1,COG0515@2	NA|NA|NA	KLT	PhoP regulatory network protein YrbL
b3208	316407.85676002	1.2e-134	485.7	Escherichia	mtgA	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008955,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.129	ko:K03814	ko00550,map00550				ko00000,ko00001,ko01000,ko01003,ko01011		GT51		Escherichia	1RDAQ@1224,1RMGB@1236,3XP9W@561,COG0744@1,COG0744@2	NA|NA|NA	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
b3209	198214.SF3249	2e-115	421.8	Gammaproteobacteria													Escherichia	1MW2K@1224,1RMDJ@1236,COG3155@1,COG3155@2	NA|NA|NA	Q	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
b3210	198214.SF3250	0.0	1419.4	Gammaproteobacteria													Escherichia	1NC9X@1224,1SVEC@1236,COG0784@1,COG0784@2,COG2198@1,COG2198@2,COG5002@1,COG5002@2	NA|NA|NA	T	Histidine kinase
b3211	155864.EDL933_4439	1.6e-182	645.2	Escherichia	yhcC	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540		ko:K07139					ko00000				Escherichia	1MUYF@1224,1RP94@1236,3XP7F@561,COG1242@1,COG1242@2	NA|NA|NA	S	4 iron, 4 sulfur cluster binding
b3212	316407.85676006	0.0	2979.1	Escherichia	gltB	GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230		R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000			iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495	Escherichia	1MU7B@1224,1RN2W@1236,3XMUK@561,COG0067@1,COG0067@2,COG0069@1,COG0069@2,COG0070@1,COG0070@2	NA|NA|NA	E	glutamate synthase
b3213	316407.85676007	6.5e-281	972.6	Escherichia	gltD	GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230		R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000			iEC042_1314.EC042_3503	Escherichia	1MU2H@1224,1RMY7@1236,3XP5J@561,COG0493@1,COG0493@2	NA|NA|NA	C	glutamate synthase
b3214	316407.85676008	6.9e-136	490.0	Gammaproteobacteria													Escherichia	1RIGE@1224,1S4HY@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Protein of unknown function (DUF1120)
b3215	316407.85676009	3.2e-121	441.0	Gammaproteobacteria													Escherichia	1R9CK@1224,1RYSR@1236,COG3121@1,COG3121@2	NA|NA|NA	NU	chaperone
b3216	316407.85676010	0.0	1544.6	Gammaproteobacteria													Escherichia	1R41Y@1224,1RZN3@1236,COG3188@1,COG3188@2	NA|NA|NA	NU	Usher protein
b3218	316407.1736552	5.6e-194	683.3	Gammaproteobacteria													Escherichia	1MVDK@1224,1RR0T@1236,COG3039@1,COG3039@2	NA|NA|NA	L	COG3039 Transposase and inactivated derivatives IS5 family
b3219	316407.85676012	8.7e-125	453.0	Gammaproteobacteria													Escherichia	1RIGE@1224,1S4HY@1236,COG3539@1,COG3539@2	NA|NA|NA	NU	Protein of unknown function (DUF1120)
b3220	316407.85676013	1.2e-213	748.8	Escherichia	yhcG												Escherichia	1NBWK@1224,1RY9R@1236,3XR0X@561,COG4804@1,COG4804@2	NA|NA|NA	S	nuclease activity
b3221	316407.85676014	1.8e-83	315.1	Escherichia	yhcH	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1RCDU@1224,1S39H@1236,3XRJF@561,COG2731@1,COG2731@2	NA|NA|NA	G	cellular response to DNA damage stimulus
b3222	316407.85676015	2.4e-156	558.1	Escherichia	nanK	GO:0003674,GO:0003824,GO:0005975,GO:0006040,GO:0006054,GO:0006082,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009384,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016999,GO:0017001,GO:0017144,GO:0019200,GO:0019262,GO:0019752,GO:0033554,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044281,GO:0044282,GO:0046348,GO:0046395,GO:0046835,GO:0050896,GO:0051716,GO:0071704,GO:1901135,GO:1901136,GO:1901575	2.7.1.60	ko:K00885	ko00520,ko01100,map00520,map01100		R02705	RC00002,RC00017	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_3494,iECO26_1355.ECO26_4321,iECSF_1327.ECSF_3047,iECs_1301.ECs4095,iSFV_1184.SFV_3247,iSFxv_1172.SFxv_3570,iZ_1308.Z4580	Escherichia	1Q78E@1224,1RRA2@1236,3XNS2@561,COG1940@1,COG1940@2	NA|NA|NA	F	Belongs to the ROK (NagC XylR) family. NanK subfamily
b3223	199310.c3977	3.5e-123	447.6	Escherichia	nanE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0006050,GO:0006051,GO:0006053,GO:0006054,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016853,GO:0016854,GO:0016857,GO:0016999,GO:0017001,GO:0017144,GO:0019262,GO:0019752,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046346,GO:0046348,GO:0046395,GO:0047465,GO:0071704,GO:1901135,GO:1901136,GO:1901575	5.1.3.9	ko:K01788	ko00520,map00520		R02087	RC00290	ko00000,ko00001,ko01000			iB21_1397.B21_03034,iECBD_1354.ECBD_0524,iECB_1328.ECB_03083,iECD_1391.ECD_03083,iEcHS_1320.EcHS_A3411,iEcolC_1368.EcolC_0483,iSFV_1184.SFV_3248,iSF_1195.SF3259,iSFxv_1172.SFxv_3571,iS_1188.S3476,iUTI89_1310.UTI89_C3653,ic_1306.c3977	Escherichia	1PRVW@1224,1RS59@1236,3XNV5@561,COG3010@1,COG3010@2	NA|NA|NA	G	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
b3224	316407.85676017	2.3e-281	974.2	Escherichia	nanT	GO:0003674,GO:0005215,GO:0005342,GO:0005351,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015077,GO:0015078,GO:0015136,GO:0015144,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015711,GO:0015739,GO:0015849,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034219,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1901264,GO:1901505,GO:1902600,GO:1903825,GO:1905039		ko:K03290					ko00000,ko02000	2.A.1.12		iECUMN_1333.ECUMN_3698	Escherichia	1MWKH@1224,1RZ3Z@1236,3XP7A@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b3225	155864.EDL933_4447	2.2e-165	588.2	Escherichia	nanA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0006054,GO:0006082,GO:0008150,GO:0008152,GO:0008747,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019262,GO:0019752,GO:0042737,GO:0042802,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046348,GO:0046395,GO:0071704,GO:1901135,GO:1901136,GO:1901575	4.1.3.3	ko:K01639	ko00520,map00520		R01811	RC00159,RC00600	ko00000,ko00001,ko01000			iAF1260.b3225,iAPECO1_1312.APECO1_3218,iB21_1397.B21_03036,iBWG_1329.BWG_2926,iE2348C_1286.E2348C_3497,iEC042_1314.EC042_3509,iEC55989_1330.EC55989_3638,iECABU_c1320.ECABU_c36330,iECBD_1354.ECBD_0522,iECB_1328.ECB_03085,iECDH10B_1368.ECDH10B_3402,iECDH1ME8569_1439.ECDH1ME8569_3113,iECD_1391.ECD_03085,iECH74115_1262.ECH74115_4542,iECIAI1_1343.ECIAI1_3367,iECNA114_1301.ECNA114_3298,iECO103_1326.ECO103_3966,iECO26_1355.ECO26_4324,iECOK1_1307.ECOK1_3639,iECP_1309.ECP_3308,iECS88_1305.ECS88_3602,iECSF_1327.ECSF_3050,iECSP_1301.ECSP_4194,iECUMN_1333.ECUMN_3699,iECs_1301.ECs4098,iETEC_1333.ETEC_3486,iEcDH1_1363.EcDH1_0481,iEcE24377_1341.EcE24377A_3707,iEcHS_1320.EcHS_A3413,iEcolC_1368.EcolC_0481,iG2583_1286.G2583_3945,iJO1366.b3225,iJR904.b3225,iSDY_1059.SDY_3400,iSFV_1184.SFV_3250,iSF_1195.SF3261,iSFxv_1172.SFxv_3573,iSSON_1240.SSON_3366,iS_1188.S3478,iSbBS512_1146.SbBS512_E3551,iUMN146_1321.UM146_00280,iUTI89_1310.UTI89_C3655,iY75_1357.Y75_RS16725,iZ_1308.Z4583	Escherichia	1Q7AX@1224,1RRZG@1236,3XP47@561,COG0329@1,COG0329@2	NA|NA|NA	H	Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate
b3226	316407.85676019	6.9e-131	473.4	Escherichia	nanR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K22104					ko00000,ko03000				Escherichia	1N6N0@1224,1RPZ0@1236,3XNGW@561,COG2186@1,COG2186@2	NA|NA|NA	K	Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids
b3227	316407.85676020	1.6e-236	825.1	Escherichia	dcuD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0008150,GO:0015711,GO:0015740,GO:0015849,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702,GO:0071944		ko:K03326					ko00000,ko02000	2.A.61.1			Escherichia	1MWBG@1224,1RQB2@1236,3XNN1@561,COG3069@1,COG3069@2	NA|NA|NA	P	Responsible for the transport of C4-dicarboxylates during anaerobic growth
b3228	155864.EDL933_4450	8.5e-87	326.2	Escherichia	sspB	GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904		ko:K03600					ko00000,ko03021				Escherichia	1MZ2Q@1224,1S8WT@1236,3XMPC@561,COG2969@1,COG2969@2	NA|NA|NA	S	the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth
b3229	1440052.EAKF1_ch2717	2.4e-118	431.4	Escherichia	sspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03599					ko00000,ko02000,ko03021	1.A.12.3.1			Escherichia	1MXJD@1224,1RP12@1236,3XM2Z@561,COG0625@1,COG0625@2	NA|NA|NA	K	Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme
b3230	1005994.GTGU_03830	8e-64	249.6	Gammaproteobacteria													Escherichia	1RD4A@1224,1S3Q7@1236,COG0103@1,COG0103@2	NA|NA|NA	J	Belongs to the universal ribosomal protein uS9 family
b3231	1440052.EAKF1_ch2715	5.3e-77	293.5	Escherichia	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02871	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1RA11@1224,1S280@1236,3XP67@561,COG0102@1,COG0102@2	NA|NA|NA	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
b3232	155864.EDL933_4454	4.5e-216	756.9	Escherichia	zapE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301		ko:K06916					ko00000,ko03036				Escherichia	1MUUW@1224,1RMTJ@1236,3XNFW@561,COG1485@1,COG1485@2	NA|NA|NA	D	Reduces the stability of FtsZ polymers in the presence of ATP
b3233	155864.EDL933_4455	7.4e-65	253.1	Escherichia	yhcB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944		ko:K09908					ko00000				Escherichia	1RE90@1224,1S3S2@1236,3XPIB@561,COG3105@1,COG3105@2	NA|NA|NA	S	oxidoreductase activity
b3234	316407.85676027	1e-243	849.0	Escherichia	degQ	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0031224,GO:0031226,GO:0031233,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051603,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575		ko:K04772					ko00000,ko01000,ko01002				Escherichia	1MU63@1224,1RN9T@1236,3XP2Q@561,COG0265@1,COG0265@2	NA|NA|NA	M	DegQ could degrade transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions. DegQ is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for a beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable to be cleaved, thereby preventing non-specific proteolysis of folded proteins. DegQ can substitute for the periplasmic protease DegP
b3235	155864.EDL933_4457	3.5e-194	684.1	Escherichia	degS	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564		ko:K04691					ko00000,ko01000,ko01002				Escherichia	1MU63@1224,1RN9T@1236,3XP1F@561,COG0265@1,COG0265@2	NA|NA|NA	O	A site-1 protease (S1P) that cleaves the peptide bond between 'Val-148' and 'Ser-149' in RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. When heat shock or other environmental stresses disrupt protein folding in the periplasm, DegS senses the accumulation of unassembled outer membrane porins (OMP) and then initiates RseA (anti sigma-E factor) degradation by cleaving its periplasmic domain, making it a substrate for subsequent cleavage by RseP. This cascade ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding stress in the periplasm and OMP assembly. Required for basal and stress-induced degradation of RseA
b3236	155864.EDL933_4458	1.9e-167	595.1	Escherichia	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006099,GO:0006101,GO:0006108,GO:0006113,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009060,GO:0009061,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015980,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019898,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0045333,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072350,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000			iEcolC_1368.EcolC_0470	Escherichia	1MV57@1224,1RMAX@1236,3XMCI@561,COG0039@1,COG0039@2	NA|NA|NA	C	Catalyzes the reversible oxidation of malate to oxaloacetate
b3237	155864.EDL933_4459	4e-78	297.4	Escherichia	argR	GO:0000820,GO:0000821,GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006310,GO:0006355,GO:0006521,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016043,GO:0016597,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031329,GO:0031333,GO:0031334,GO:0031406,GO:0033238,GO:0033241,GO:0034214,GO:0034618,GO:0034641,GO:0036094,GO:0042150,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051259,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1900079,GO:1900081,GO:1901360,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2000144,GO:2000282,GO:2001141		ko:K03402					ko00000,ko03000				Escherichia	1N2AF@1224,1RSF7@1236,3XN1P@561,COG1438@1,COG1438@2	NA|NA|NA	K	Regulates arginine biosynthesis genes
b3238	155864.EDL933_4460	2.1e-23	114.8	Escherichia	yhcN	GO:0000302,GO:0006950,GO:0006979,GO:0008150,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010447,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044011,GO:0044764,GO:0046677,GO:0050896,GO:0051703,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0090605,GO:0090609,GO:0097237,GO:0104004,GO:1901700,GO:1901701											Escherichia	1N52F@1224,1S957@1236,2CAQ2@1,31NM5@2,3XPYP@561	NA|NA|NA	S	cellular response to acidic pH
b3239	155864.EDL933_4461	1.3e-44	185.3	Escherichia	yhcO			ko:K03623					ko00000				Escherichia	1MZ53@1224,1S8RD@1236,3XPUY@561,COG2732@1,COG2732@2	NA|NA|NA	K	Barstar (barnase inhibitor)
b3240	316407.85676033	0.0	1266.1	Escherichia	aaeB	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0015849,GO:0016020,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702,GO:0071944		ko:K03468					ko00000,ko02000	2.A.85.1.2			Escherichia	1MX9H@1224,1RPFA@1236,3XMK5@561,COG1289@1,COG1289@2	NA|NA|NA	U	Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell
b3241	316407.85676034	9.2e-167	592.8	Escherichia	aaeA	GO:0003674,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015711,GO:0015849,GO:0015893,GO:0015906,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0045117,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072348,GO:1901474,GO:1901682,GO:1902599		ko:K15548					ko00000,ko02000	8.A.1.7.1			Escherichia	1MWG0@1224,1RPC8@1236,3XMB6@561,COG1566@1,COG1566@2	NA|NA|NA	V	P-hydroxybenzoic acid efflux pump subunit AaeA
b3242	1114922.CIFAM_19_00390	5.6e-29	132.9	Citrobacter													Escherichia	1N7N9@1224,1SCX3@1236,2DNQE@1,32YJX@2,3WYUM@544	NA|NA|NA	S	Protein of unknown function (DUF1656)
b3243	199310.c3998	7.2e-172	609.8	Escherichia	aaeR	GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K21698					ko00000,ko03000				Escherichia	1PTTR@1224,1RRTB@1236,3XP4Q@561,COG0583@1,COG0583@2	NA|NA|NA	K	Activates transcription of the aaeXAB operon
b3244	198214.SF3283	1.1e-270	938.7	Gammaproteobacteria													Escherichia	1MUSK@1224,1RMA5@1236,COG0312@1,COG0312@2	NA|NA|NA	S	'responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase
b4472	316407.85676038	0.0	2585.1	Escherichia	yhdP	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Escherichia	1MXWF@1224,1RNUK@1236,3XMN7@561,COG3164@1,COG3164@2	NA|NA|NA	S	Protein of unknown function
b3247	155864.EDL933_4468	1.5e-275	954.9	Escherichia	rng	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360		ko:K08301					ko00000,ko01000,ko03009,ko03019				Escherichia	1MV65@1224,1RMIW@1236,3XM8G@561,COG1530@1,COG1530@2	NA|NA|NA	J	Involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filaments bundles or merely regulate the formation of this structure
b3248	316407.85676040	1.6e-103	382.1	Escherichia	yhdE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429		ko:K06287					ko00000				Escherichia	1RH6H@1224,1S41D@1236,3XMC4@561,COG0424@1,COG0424@2	NA|NA|NA	D	UTP diphosphatase activity
b3249	155864.EDL933_4470	6.2e-82	310.1	Escherichia	mreD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944		ko:K03571					ko00000,ko03036	9.B.157.1			Escherichia	1RER7@1224,1S8VI@1236,3XPDW@561,COG2891@1,COG2891@2	NA|NA|NA	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
b3250	155864.EDL933_4471	2.3e-172	611.7	Escherichia	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0043621,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944,GO:0071963		ko:K03570					ko00000,ko03036	9.B.157.1			Escherichia	1N8ZS@1224,1RMK4@1236,3XNFQ@561,COG1792@1,COG1792@2	NA|NA|NA	M	shape-determining protein MreC
b3251	1006000.GKAS_00120	2.3e-190	671.4	Gammaproteobacteria													Escherichia	1MUMW@1224,1RN82@1236,COG1077@1,COG1077@2	NA|NA|NA	D	rod shape-determining protein MreB
b3252	316407.85676044	0.0	1274.2	Escherichia	csrD	GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016070,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0031323,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K18765					ko00000,ko03019				Escherichia	1MUQV@1224,1RN0Q@1236,3XMX0@561,COG2199@1,COG2199@2,COG2200@1,COG2200@2	NA|NA|NA	T	Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility gene expression, is also required for curli expression
b3253	316407.85676045	4.7e-182	643.7	Escherichia	yhdH	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0043957,GO:0055114		ko:K19745	ko00640,ko01100,map00640,map01100		R00919	RC00095	ko00000,ko00001,ko01000				Escherichia	1MV3W@1224,1RMHG@1236,3XP5P@561,COG0604@1,COG0604@2	NA|NA|NA	C	acryloyl-CoA reductase (NADP+) activity
b3255	155864.EDL933_4477	2.4e-75	288.1	Escherichia	accB	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576		ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002				Escherichia	1RCXA@1224,1S3YP@1236,3XM9J@561,COG0511@1,COG0511@2	NA|NA|NA	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
b3256	316407.85676047	2.3e-259	901.0	Escherichia	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000			iSF_1195.SF3294	Escherichia	1MU4H@1224,1RMNB@1236,3XP5G@561,COG0439@1,COG0439@2	NA|NA|NA	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
b3257	316407.85676048	2.2e-40	171.0	Escherichia	yhdT												Escherichia	1MZ8K@1224,1S8QV@1236,3XPXX@561,COG3924@1,COG3924@2	NA|NA|NA	S	Protein of unknown function (DUF997)
b3258	155864.EDL933_4480	9.7e-248	862.4	Escherichia	panF	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015233,GO:0015238,GO:0015291,GO:0015293,GO:0015318,GO:0015711,GO:0015718,GO:0015849,GO:0015887,GO:0015893,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051184,GO:0051185,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072349,GO:0090482,GO:0098656,GO:1903825,GO:1905039		ko:K14392					ko00000,ko02000	2.A.21.1		iE2348C_1286.E2348C_3528,iECED1_1282.ECED1_3917,iECP_1309.ECP_3351	Escherichia	1QUAY@1224,1RP9P@1236,3XNIQ@561,COG4145@1,COG4145@2	NA|NA|NA	H	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
b3259	155864.EDL933_4481	4.2e-169	600.5	Escherichia	prmA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006480,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018011,GO:0018012,GO:0018022,GO:0018023,GO:0018193,GO:0018194,GO:0018205,GO:0019538,GO:0031365,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564		ko:K02687					ko00000,ko01000,ko03009				Escherichia	1MUPC@1224,1RNAR@1236,3XPE5@561,COG2264@1,COG2264@2	NA|NA|NA	J	Methylates ribosomal protein L11
b3260	199310.c4026	2.9e-184	651.0	Escherichia	dusB	GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360		ko:K05540					ko00000,ko01000,ko03016				Escherichia	1MV5V@1224,1RMJP@1236,3XNH8@561,COG0042@1,COG0042@2	NA|NA|NA	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
b3261	1005994.GTGU_03789	7.4e-46	189.5	Gammaproteobacteria													Escherichia	1N7MJ@1224,1SD35@1236,COG2901@1,COG2901@2	NA|NA|NA	K	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
b3262	316407.85676053	6.4e-170	603.2	Escherichia	yhdJ	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009007,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0032775,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044728,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360	2.1.1.72	ko:K07319					ko00000,ko01000,ko02048				Escherichia	1MX9M@1224,1S17I@1236,3XMME@561,COG2189@1,COG2189@2	NA|NA|NA	L	Belongs to the N(4) N(6)-methyltransferase family
b3263	199310.c4029	1.1e-25	121.7	Escherichia	yhdU												Escherichia	1N88G@1224,1SD0T@1236,2E736@1,331MQ@2,3XR8B@561	NA|NA|NA	S	Protein of unknown function (DUF2556)
b3264	155864.EDL933_4486	2.7e-120	438.0	Escherichia	envR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K18140		M00696			ko00000,ko00002,ko01504,ko03000				Escherichia	1RCKE@1224,1S3A5@1236,3XP9B@561,COG1309@1,COG1309@2	NA|NA|NA	K	acrEF envCD operon repressor
b3265	316407.85676056	2.4e-209	734.6	Escherichia	acrE	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015893,GO:0016020,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K18141		M00696			ko00000,ko00002,ko01504,ko02000	2.A.6.2,8.A.1			Escherichia	1MU78@1224,1RPI1@1236,3XNKF@561,COG0845@1,COG0845@2	NA|NA|NA	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
b3266	316407.85676057	0.0	1946.0	Escherichia	acrF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K18142		M00696			ko00000,ko00002,ko01504,ko02000	2.A.6.2		iAF1260.b3266,iJO1366.b3266,iZ_1308.Z4627	Escherichia	1MU48@1224,1RMBN@1236,3XP6I@561,COG0841@1,COG0841@2	NA|NA|NA	U	efflux transmembrane transporter activity
b3267	1114922.CIFAM_19_00050	1.8e-33	147.9	Citrobacter													Escherichia	1N0QR@1224,1S8YI@1236,2CDN7@1,32RY2@2,3WYRQ@544	NA|NA|NA	S	Protein involved in biological_process
b3269	316407.85676060	2.6e-214	751.1	Escherichia	yhdX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K09970	ko02010,map02010	M00232			ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8			Escherichia	1MV0S@1224,1RN6V@1236,3XNNW@561,COG4597@1,COG4597@2	NA|NA|NA	P	amino-acid ABC transporter permease protein YhdX
b3270	316407.85676061	2.1e-210	738.0	Escherichia	yhdY	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K09971	ko02010,map02010	M00232			ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8			Escherichia	1MV3I@1224,1RPJR@1236,3XMT2@561,COG0765@1,COG0765@2	NA|NA|NA	P	amino-acid ABC transporter permease protein YhdY
b3271	316407.85676062	2.2e-142	511.5	Escherichia	yhdZ	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K09972	ko02010,map02010	M00232			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8			Escherichia	1MU9Q@1224,1RMX1@1236,3XMTZ@561,COG1126@1,COG1126@2	NA|NA|NA	P	amino-acid ABC transporter ATP-binding protein YhdZ
b3279	155864.EDL933_4497	4.6e-89	334.0	Escherichia	yrdA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071840											Escherichia	1RD76@1224,1RPB6@1236,3XNFA@561,COG0663@1,COG0663@2	NA|NA|NA	S	protein homotrimerization
b3280	316407.85676761	4.2e-45	186.8	Escherichia	yrdB												Escherichia	1N7X6@1224,1SC8J@1236,2E6QS@1,331AY@2,3XQ1C@561	NA|NA|NA	S	Protein of unknown function (DUF1488)
b3281	316407.85676760	4.3e-152	543.9	Escherichia	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_3165,iECOK1_1307.ECOK1_3701,iECS88_1305.ECS88_3669,iECUMN_1333.ECUMN_3755,iSBO_1134.SBO_3275,iUMN146_1321.UM146_16315,iUTI89_1310.UTI89_C3726	Escherichia	1MVH4@1224,1RPB7@1236,3XN0P@561,COG0169@1,COG0169@2	NA|NA|NA	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
b3282	316407.85676759	1.4e-104	385.6	Escherichia	rimN	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061710,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566			R10463	RC00745	ko00000,ko01000,ko03009,ko03016				Escherichia	1MVPM@1224,1S610@1236,3XN9Z@561,COG0009@1,COG0009@2	NA|NA|NA	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate
b3283	316407.85676758	1.2e-78	299.3	Escherichia	yrdD	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005506,GO:0008270,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0097159,GO:1901363		ko:K07479					ko00000				Escherichia	1MX2E@1224,1RQ85@1236,3XN35@561,COG0551@1,COG0551@2	NA|NA|NA	L	DNA topological change
b3284	316407.85676757	1.9e-83	315.1	Escherichia	smg			ko:K03747					ko00000				Escherichia	1RD5F@1224,1S43X@1236,3XMN5@561,COG2922@1,COG2922@2	NA|NA|NA	S	Protein of unknown function (DUF494)
b4473	316407.85676756	8.9e-217	759.2	Escherichia	smf			ko:K04096					ko00000				Escherichia	1MVF6@1224,1RPJE@1236,3XP00@561,COG0758@1,COG0758@2	NA|NA|NA	LU	Partially complements natural chromosomal DNA transformation defect of an H.influenzae dprA disruption mutant. May help load RecA onto ssDNA (By similarity)
b3287	155864.EDL933_4504	1.5e-86	325.5	Escherichia	def	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043021,GO:0043022,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:1901564	3.5.1.88	ko:K01462					ko00000,ko01000				Escherichia	1RA2P@1224,1S247@1236,3XNEA@561,COG0242@1,COG0242@2	NA|NA|NA	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
b3288	316407.85676754	7.6e-177	626.3	Escherichia	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970		R03940	RC00026,RC00165	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048	Escherichia	1MU4Q@1224,1RP1T@1236,3XNR9@561,COG0223@1,COG0223@2	NA|NA|NA	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
b3289	316407.85676753	1.5e-252	878.2	Escherichia	rsmB	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500					ko00000,ko01000,ko03009				Escherichia	1MWPE@1224,1RN8X@1236,3XN6S@561,COG0144@1,COG0144@2,COG0781@1,COG0781@2	NA|NA|NA	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
b3290	155864.EDL933_4507	1.9e-253	881.3	Escherichia	trkA	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655		ko:K03499					ko00000,ko02000	2.A.38.1,2.A.38.4		iE2348C_1286.E2348C_3552	Escherichia	1MW8R@1224,1RNVQ@1236,3XNHZ@561,COG0569@1,COG0569@2	NA|NA|NA	P	Part of the constitutive potassium transport systems TrkG and TrkH. May regulate the transport activity of TrkG and TrkH systems. Binds to NAD( ) and NADH
b3291	155864.EDL933_4508	8.9e-66	256.1	Escherichia	mscL	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0008150,GO:0008381,GO:0015267,GO:0016020,GO:0016021,GO:0022803,GO:0022836,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K03282					ko00000,ko02000	1.A.22.1			Escherichia	1RHG8@1224,1S3PD@1236,3XPMG@561,COG1970@1,COG1970@2	NA|NA|NA	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
b4550	316407.85676750	9.6e-35	152.1	Escherichia	yhdL	GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006412,GO:0006414,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112		ko:K09890					ko00000,ko03012				Escherichia	1N709@1224,1SDRD@1236,3XQ3B@561,COG3036@1,COG3036@2	NA|NA|NA	S	Rescues ribosomes stalled at the 3' end of non-stop mRNAs. This activity is crucial when the stalled ribosome cannot be rescued by the SsrA(tmRNA)- SmpB quality control system. Binds the 30S subunit, contacting 16S rRNA with the N-terminus near the decoding center and its C-terminus in the mRNA entry channel
b3292	155864.EDL933_4509	3.9e-72	277.3	Escherichia	zntR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K13638					ko00000,ko03000				Escherichia	1MZ3P@1224,1SA5G@1236,3XPN1@561,COG0789@1,COG0789@2	NA|NA|NA	K	Transcriptional regulator
b3293	316407.85676748	3.4e-64	250.8	Escherichia	yhdN												Escherichia	1NAHU@1224,1S9DD@1236,2D7FD@1,32TNY@2,3XPSQ@561	NA|NA|NA	S	Domain of unknown function (DUF1992)
b3294	1399774.JDWH01000027_gene3583	9.6e-62	242.7	Enterobacter													Escherichia	1RCWN@1224,1S3QK@1236,3X29H@547,COG0203@1,COG0203@2	NA|NA|NA	J	Ribosomal protein L17
b3295	1114922.CIFAM_27_00320	1.1e-181	642.5	Citrobacter													Escherichia	1MU75@1224,1RMU3@1236,3WW1W@544,COG0202@1,COG0202@2	NA|NA|NA	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
b3296	199310.c4057	5.8e-109	400.2	Escherichia	rpsD	GO:0000028,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006446,GO:0006450,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030371,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032269,GO:0032270,GO:0032991,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045727,GO:0045903,GO:0045947,GO:0048027,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990145,GO:1990904,GO:2000112,GO:2000113,GO:2001141		ko:K02986	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1MW0U@1224,1RQ38@1236,3XNVS@561,COG0522@1,COG0522@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
b3297	1114922.CIFAM_27_00300	4.5e-67	260.4	Citrobacter													Escherichia	1RD0A@1224,1S3Q2@1236,3WY9K@544,COG0100@1,COG0100@2	NA|NA|NA	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
b3298	754331.AEME01000001_gene3788	4.3e-56	223.8	Escherichia	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02952	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1RD1G@1224,1S3NX@1236,3XPPN@561,COG0099@1,COG0099@2	NA|NA|NA	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
b3299	1005994.GTGU_03003	4.2e-13	79.3	Gammaproteobacteria													Escherichia	1NGEI@1224,1SGC9@1236,COG0257@1,COG0257@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL36 family
b3300	155864.EDL933_4517	2.5e-242	844.3	Escherichia	secY	GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680		ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5			Escherichia	1MVU7@1224,1RNJV@1236,3XNT2@561,COG0201@1,COG0201@2	NA|NA|NA	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
b3301	316407.85676740	5e-59	233.8	Escherichia	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904		ko:K02876	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1RDC8@1224,1S3P6@1236,3XPK7@561,COG0200@1,COG0200@2	NA|NA|NA	J	Binds to the 23S rRNA
b3302	1440052.EAKF1_ch2649	4.8e-24	116.3	Escherichia	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904		ko:K02907	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1N6ZE@1224,1SC8N@1236,3XQ3P@561,COG1841@1,COG1841@2	NA|NA|NA	J	structural constituent of ribosome
b3303	1114922.CIFAM_27_00250	2.8e-85	321.2	Citrobacter													Escherichia	1MUS4@1224,1RNEV@1236,3WV8F@544,COG0098@1,COG0098@2	NA|NA|NA	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
b3304	1006000.GKAS_02825	1.2e-45	189.1	Gammaproteobacteria													Escherichia	1RGY7@1224,1S5V2@1236,COG0256@1,COG0256@2	NA|NA|NA	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
b3305	155864.EDL933_4522	1.3e-93	349.0	Escherichia	rplF	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02933	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1R9YZ@1224,1S1Z1@1236,3XPDH@561,COG0097@1,COG0097@2	NA|NA|NA	J	is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
b3306	1114922.CIFAM_27_00220	6.1e-64	250.0	Citrobacter													Escherichia	1RDG3@1224,1S452@1236,3WYA3@544,COG0096@1,COG0096@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
b3307	1005994.GTGU_03011	2.8e-48	197.6	Gammaproteobacteria													Escherichia	1MZDT@1224,1S62N@1236,COG0199@1,COG0199@2	NA|NA|NA	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
b3308	1166130.H650_13010	8.4e-96	356.3	Enterobacter													Escherichia	1MUU9@1224,1RPE1@1236,3X0U0@547,COG0094@1,COG0094@2	NA|NA|NA	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
b3309	1045856.EcWSU1_04111	2e-49	201.4	Enterobacter													Escherichia	1MZQD@1224,1S973@1236,3X2E6@547,COG0198@1,COG0198@2	NA|NA|NA	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
b3310	198214.SF3342	1.6e-61	241.9	Gammaproteobacteria													Escherichia	1RCWZ@1224,1S3Z3@1236,COG0093@1,COG0093@2	NA|NA|NA	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
b3311	1224318.DT73_19190	3.1e-40	170.6	Gammaproteobacteria													Escherichia	1MZIK@1224,1S8SS@1236,COG0186@1,COG0186@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
b3312	155864.EDL933_4529	1.5e-23	114.8	Escherichia	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904		ko:K02904	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1N6PR@1224,1SCBN@1236,3XPZK@561,COG0255@1,COG0255@2	NA|NA|NA	J	ribosomal protein L29
b3313	1440052.EAKF1_ch2638	1.7e-69	268.5	Escherichia	rplP	GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1990904		ko:K02878	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1RA0Z@1224,1S201@1236,3XPK2@561,COG0197@1,COG0197@2	NA|NA|NA	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
b3314	1005994.GTGU_03018	3.8e-125	454.1	Gammaproteobacteria													Escherichia	1MUAI@1224,1RN0P@1236,COG0092@1,COG0092@2	NA|NA|NA	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
b3315	1073999.BN137_4056	2.3e-51	208.0	Gammaproteobacteria													Escherichia	1RH0W@1224,1S5XT@1236,COG0091@1,COG0091@2	NA|NA|NA	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
b3316	1006000.GKAS_02813	2.4e-46	191.0	Gammaproteobacteria													Escherichia	1RGYX@1224,1S5VT@1236,COG0185@1,COG0185@2	NA|NA|NA	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
b3317	1073999.BN137_4054	3.5e-154	550.8	Gammaproteobacteria													Escherichia	1MVTD@1224,1RMGR@1236,COG0090@1,COG0090@2	NA|NA|NA	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
b3318	1440052.EAKF1_ch2633	2.9e-45	187.6	Escherichia	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02892	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1MZXX@1224,1S8VX@1236,3XPXA@561,COG0089@1,COG0089@2	NA|NA|NA	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome
b3319	1005994.GTGU_03023	3e-102	377.9	Gammaproteobacteria													Escherichia	1MXPF@1224,1RNNK@1236,COG0088@1,COG0088@2	NA|NA|NA	J	Forms part of the polypeptide exit tunnel
b3320	155864.EDL933_4537	1.1e-110	406.0	Escherichia	rplC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904		ko:K02906	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1MUST@1224,1RMK9@1236,3XNYM@561,COG0087@1,COG0087@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
b3321	1440052.EAKF1_ch2630	4.4e-49	200.3	Escherichia	rpsJ	GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141		ko:K02946	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1RGWF@1224,1S3QX@1236,3XPQU@561,COG0051@1,COG0051@2	NA|NA|NA	J	Involved in the binding of tRNA to the ribosomes
b3322	316407.85676719	1.2e-52	212.6	Gammaproteobacteria													Escherichia	1NH2G@1224,1SIPT@1236,2EHNQ@1,33BEH@2	NA|NA|NA	S	Part of a cryptic operon that encodes proteins involved in type II secretion pathway in other organisms, but is not expressed in strain K12 under standard laboratory conditions. May play a regulatory role under conditions of derepressed gsp gene expression
b3323	316407.85676718	2.6e-285	987.3	Gammaproteobacteria													Escherichia	1MU3G@1224,1RMI0@1236,COG3267@1,COG3267@2,COG3409@1,COG3409@2	NA|NA|NA	U	Type II secretory pathway component ExeA
b3324	316407.85676717	1.5e-149	535.4	Gammaproteobacteria													Escherichia	1NIIJ@1224,1SI3E@1236,COG3031@1,COG3031@2	NA|NA|NA	U	General secretion pathway protein C
b3325	316407.85676716	0.0	1242.3	Escherichia	gspD			ko:K02453	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Escherichia	1MUUA@1224,1RPJS@1236,3XNXY@561,COG1450@1,COG1450@2	NA|NA|NA	NU	General secretion pathway protein
b3326	316407.85676715	2e-272	944.5	Gammaproteobacteria													Escherichia	1MU7V@1224,1RMBS@1236,COG2804@1,COG2804@2	NA|NA|NA	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
b3327	316407.85676714	3.5e-211	740.7	Escherichia	gspF	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776		ko:K02455	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Escherichia	1MV4U@1224,1RQ86@1236,3XN4J@561,COG1459@1,COG1459@2	NA|NA|NA	U	General secretion pathway
b3328	316407.85676713	6.4e-78	296.6	Escherichia	gspG			ko:K02456	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Escherichia	1RDX2@1224,1S3VS@1236,3XPD0@561,COG2165@1,COG2165@2	NA|NA|NA	U	General secretion pathway protein
b3329	316407.85676712	8.5e-90	336.3	Gammaproteobacteria													Escherichia	1NP8Q@1224,1SGBJ@1236,COG2165@1,COG2165@2	NA|NA|NA	U	general secretion pathway protein
b3330	316407.85676711	5.2e-60	236.9	Bacteria													Escherichia	COG2165@1,COG2165@2	NA|NA|NA	NU	general secretion pathway protein
b3331	316407.85676710	1.7e-81	308.9	Gammaproteobacteria													Escherichia	1N942@1224,1SED4@1236,COG4795@1,COG4795@2	NA|NA|NA	U	type II secretion system protein
b3332	316407.85676709	1.3e-182	645.6	Escherichia	gspK			ko:K02460	ko03070,ko05111,map03070,map05111	M00331			ko00000,ko00001,ko00002,ko02044	3.A.15			Escherichia	1RC9P@1224,1T072@1236,3XPI1@561,COG3156@1,COG3156@2	NA|NA|NA	U	Type II secretion system
b3333	316407.85676708	2.4e-225	787.7	Bacteria													Escherichia	COG3297@1,COG3297@2	NA|NA|NA	U	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
b3334	316407.85676707	3.4e-82	310.8	Gammaproteobacteria													Escherichia	1NGFT@1224,1SIFJ@1236,COG3149@1,COG3149@2	NA|NA|NA	U	PFAM General secretion pathway, M protein
b3335	316407.85676706	6.3e-125	453.4	Gammaproteobacteria													Escherichia	1MUZF@1224,1RN90@1236,COG1989@1,COG1989@2	NA|NA|NA	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
b3336	199310.c4107	1.3e-84	318.9	Escherichia	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0020037,GO:0030003,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0097159,GO:0097577,GO:0098771,GO:1901363	1.16.3.1	ko:K03594	ko00860,map00860		R00078	RC02758	ko00000,ko00001,ko01000				Escherichia	1RCW7@1224,1S45S@1236,3XN6R@561,COG2193@1,COG2193@2	NA|NA|NA	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex
b3337	199310.c4108	4.9e-30	136.3	Escherichia	bfd	GO:0003674,GO:0005488,GO:0048037,GO:0051536,GO:0051537,GO:0051540		ko:K02192					ko00000				Escherichia	1N86H@1224,1SCIU@1236,3XQ0Z@561,COG2906@1,COG2906@2	NA|NA|NA	P	could be a general redox and or regulatory component participating in the iron storage mobilization functions of BFR. Could participate in the release or the delivery of iron from to bacterioferritin (or other iron complexes)
b3338	316407.85676703	0.0	1715.7	Gammaproteobacteria													Escherichia	1R5T0@1224,1RQXW@1236,COG3979@1,COG3979@2	NA|NA|NA	G	endochitinase activity
b3339	199310.c4111	1.5e-225	788.5	Escherichia													Escherichia	1MVC0@1224,1RMYX@1236,3XN6C@561,COG0050@1,COG0050@2	NA|NA|NA	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
b3340	1440052.EAKF1_ch2625	0.0	1402.5	Escherichia	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02355					ko00000,ko03012,ko03029				Escherichia	1MUCV@1224,1RNSZ@1236,3XMEB@561,COG0480@1,COG0480@2	NA|NA|NA	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
b3341	316407.85676700	4.7e-91	340.5	Escherichia	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006996,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112,GO:2000113		ko:K02992	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1MXC8@1224,1RN77@1236,3XMJS@561,COG0049@1,COG0049@2	NA|NA|NA	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center
b3342	1005994.GTGU_03045	2.6e-64	251.1	Gammaproteobacteria													Escherichia	1RCWY@1224,1S3WB@1236,COG0048@1,COG0048@2	NA|NA|NA	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
b3343	316407.85676698	8.5e-47	192.6	Escherichia	tusB	GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234		ko:K07237	ko04122,map04122				ko00000,ko00001,ko03016				Escherichia	1NGF3@1224,1SGPI@1236,3XPX0@561,COG2168@1,COG2168@2	NA|NA|NA	J	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions
b3344	316407.85676697	4.4e-61	240.4	Escherichia	tusC	GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234		ko:K07236	ko04122,map04122				ko00000,ko00001,ko03016				Escherichia	1N8RV@1224,1SD0S@1236,3XPSC@561,COG2923@1,COG2923@2	NA|NA|NA	J	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions
b3345	316407.85676696	6e-64	250.0	Escherichia	tusD	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360,GO:1902494,GO:1990228,GO:1990234		ko:K07235	ko04122,map04122				ko00000,ko00001,ko01000,ko03016				Escherichia	1N021@1224,1S99J@1236,3XPIA@561,COG1553@1,COG1553@2	NA|NA|NA	J	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
b3346	198214.SF3364	5.3e-130	470.3	Gammaproteobacteria													Escherichia	1MU5K@1224,1RPDQ@1236,COG2964@1,COG2964@2	NA|NA|NA	S	protein conserved in bacteria
b3347	316407.85676694	1.1e-139	502.7	Escherichia	fkpA	GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042026,GO:0042597,GO:0044464	5.2.1.8	ko:K03772					ko00000,ko01000,ko03110				Escherichia	1RDA1@1224,1RPMP@1236,3XRHK@561,COG0545@1,COG0545@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
b3348	155864.EDL933_4551	7.1e-30	136.0	Escherichia	slyX			ko:K03745					ko00000				Escherichia	1NGFM@1224,1SGAM@1236,3XPZ6@561,COG2900@1,COG2900@2	NA|NA|NA	S	Belongs to the SlyX family
b3349	155864.EDL933_4552	4e-83	314.3	Escherichia	slyD	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010467,GO:0016151,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022417,GO:0031647,GO:0035821,GO:0036211,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043963,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044501,GO:0046872,GO:0046914,GO:0050821,GO:0050896,GO:0050897,GO:0051082,GO:0051604,GO:0051701,GO:0051704,GO:0051817,GO:0052027,GO:0052250,GO:0065007,GO:0065008,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03775					ko00000,ko01000,ko03110				Escherichia	1RD35@1224,1S3QR@1236,3XMA6@561,COG1047@1,COG1047@2	NA|NA|NA	O	Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction. SlyD could be involved in Tat-dependent translocation, by binding to the Tat-type signal of folded proteins
b4551	155864.EDL933_4553	4.1e-32	143.3	Escherichia	yheV			ko:K07070					ko00000				Escherichia	1N6RJ@1224,1SC9Y@1236,3XQ22@561,COG3529@1,COG3529@2	NA|NA|NA	S	Probable metal-binding protein (DUF2387)
b3350	316407.85676690	0.0	1119.0	Escherichia	kefB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K11747					ko00000,ko02000	2.A.37.1.2		iB21_1397.B21_03153,iEC55989_1330.EC55989_3754,iECBD_1354.ECBD_0398,iECB_1328.ECB_03201,iECD_1391.ECD_03201,iECO26_1355.ECO26_4439,iECSE_1348.ECSE_3612,iECW_1372.ECW_m3606,iEKO11_1354.EKO11_0394,iEcHS_1320.EcHS_A3547,iSFV_1184.SFV_3356,iSSON_1240.SSON_3481,iWFL_1372.ECW_m3606	Escherichia	1MV34@1224,1RNVR@1236,3XNFT@561,COG0475@1,COG0475@2,COG1226@1,COG1226@2	NA|NA|NA	P	Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K( ) H( ) antiport
b3351	155864.EDL933_4555	2.7e-105	387.9	Escherichia	kefG			ko:K11748					ko00000,ko02000	2.A.37.1.2			Escherichia	1MXFT@1224,1RMVS@1236,3XP5S@561,COG2249@1,COG2249@2	NA|NA|NA	S	Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB
b3352	155864.EDL933_4556	0.0	1127.1	Escherichia	yheS	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K06158					ko00000,ko03012				Escherichia	1MU37@1224,1RPES@1236,3XNB3@561,COG0488@1,COG0488@2	NA|NA|NA	S	ABC transporter, ATP-binding protein
b3353	316407.85676687	1.3e-203	715.3	Escherichia	yheT	GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0050526,GO:0052689,GO:0071704		ko:K07019					ko00000				Escherichia	1MWV1@1224,1RN39@1236,3XMVG@561,COG0429@1,COG0429@2	NA|NA|NA	S	poly(3-hydroxybutyrate) depolymerase activity
b3354	1440052.EAKF1_ch2610c	4.8e-34	149.8	Escherichia	yheU			ko:K09898					ko00000				Escherichia	1N6TM@1224,1SCDE@1236,3XQ0T@561,COG3089@1,COG3089@2	NA|NA|NA	S	Belongs to the UPF0270 family
b3355	198214.SF3374	5.6e-166	590.1	Gammaproteobacteria													Escherichia	1MWN9@1224,1RMS7@1236,COG3954@1,COG3954@2	NA|NA|NA	G	Phosphoribulokinase
b3356	155864.EDL933_4560	1.6e-67	261.9	Escherichia	yhfA			ko:K07397					ko00000				Escherichia	1RCZW@1224,1S3XF@1236,3XPIF@561,COG1765@1,COG1765@2	NA|NA|NA	O	OsmC-like protein
b3357	1440052.EAKF1_ch2607c	3.2e-115	421.0	Escherichia	crp	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045013,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045990,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111				ko00000,ko00001,ko03000				Escherichia	1MXID@1224,1RMIZ@1236,3XPHB@561,COG0664@1,COG0664@2	NA|NA|NA	K	class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)- binding site, whereas in class II promoters the single CRP- and RNAP-binding site overlap, CRP making multiple contacts with RNAP. Class III promoters require multiple activator molecules, including at least one CRP dimer. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA (about 87 degrees), bringing upstream promoter elements into contact with RNAP. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. High levels of active CRP are detrimental to growth. Plays a major role in carbon catabolite repression (CCR). CCR involves cAMP, adenylate cyclase (cyaA), CRP and the EIIA-Glc component of the PTS (crr). In the presence of glucose EIIA-Glc is dephosphorylated, and does not activate adenylate cyclase, leading to reduced cAMP and thus decreased CRP activity. Also plays a role in many other processes (see PubMed 22573269)
b3358	316407.85676682	0.0	1376.7	Escherichia	yhfK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1NJVZ@1224,1RP8F@1236,3XNYG@561,COG1289@1,COG1289@2	NA|NA|NA	S	FUSC-like inner membrane protein yccS
b3359	316407.85676681	6.5e-237	826.2	Escherichia	argD	GO:0003674,GO:0003824,GO:0003992,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006553,GO:0006591,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009016,GO:0009058,GO:0009064,GO:0009066,GO:0009067,GO:0009084,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0036094,GO:0042450,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007			iSFV_1184.SFV_3365,iSF_1195.SF3378,iSFxv_1172.SFxv_3689,iSSON_1240.SSON_3490,iS_1188.S4385	Escherichia	1MV3C@1224,1RMV1@1236,3XPBV@561,COG4992@1,COG4992@2	NA|NA|NA	E	Involved in both the arginine and lysine biosynthetic pathways
b3360	316407.85676680	2.4e-106	391.3	Escherichia	pabA	GO:0000162,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85	ko:K01664	ko00790,map00790		R01716	RC00010,RC01418	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_3095,iEC042_1314.EC042_3623,iECABU_c1320.ECABU_c37840,iECED1_1282.ECED1_4024,iECNA114_1301.ECNA114_3463,iECOK1_1307.ECOK1_3780,iECP_1309.ECP_3451,iECS88_1305.ECS88_3751,iECSF_1327.ECSF_3187,iLF82_1304.LF82_1586,iNRG857_1313.NRG857_16660,iUMN146_1321.UM146_16880,iUTI89_1310.UTI89_C3863,ic_1306.c4135	Escherichia	1MV5Y@1224,1RMQW@1236,3XN45@561,COG0512@1,COG0512@2	NA|NA|NA	EH	Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB
b3361	316407.85676679	2.4e-112	411.4	Escherichia	fic	GO:0008150,GO:0050789,GO:0050794,GO:0051302,GO:0065007		ko:K04095					ko00000,ko03036				Escherichia	1R72A@1224,1RYM7@1236,3XM4Y@561,COG2184@1,COG2184@2	NA|NA|NA	D	adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (By similarity). Involved in cell filamentation induced by cyclic AMP. May have some role in cell division
b3362	155864.EDL933_4566	1e-20	105.1	Escherichia	yhfG												Escherichia	1N9B8@1224,1SE93@1236,2EDND@1,337I4@2,3XQ66@561	NA|NA|NA	S	Protein of unknown function (DUF2559)
b3363	155864.EDL933_4567	1.2e-100	372.5	Escherichia	ppiA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005623,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0071704,GO:0140096,GO:1901564	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217				ko00000,ko00001,ko01000,ko03110,ko04147				Escherichia	1R9ZQ@1224,1RP9U@1236,3XMM6@561,COG0652@1,COG0652@2	NA|NA|NA	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
b3364	199310.c4139	1.2e-216	758.8	Escherichia	tsgA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0010035,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0072714		ko:K06141					ko00000,ko02000	2.A.1			Escherichia	1NTMP@1224,1RSCQ@1236,3XMC1@561,COG0738@1,COG0738@2	NA|NA|NA	G	response to selenite ion
b3365	316407.85676675	0.0	1728.4	Escherichia	nirB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0020037,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044464,GO:0045333,GO:0046857,GO:0046906,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051536,GO:0051540,GO:0055114,GO:0097159,GO:0098809,GO:1901265,GO:1901363	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_3849	Escherichia	1MW58@1224,1RNGY@1236,3XM6G@561,COG1251@1,COG1251@2	NA|NA|NA	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
b3366	1440052.EAKF1_ch2598c	4.6e-57	226.9	Escherichia	nirD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0008942,GO:0009061,GO:0009344,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0046857,GO:0055114,GO:0098809	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_3772	Escherichia	1MZBY@1224,1S9F1@1236,3XPX5@561,COG2146@1,COG2146@2	NA|NA|NA	P	Rieske-like [2Fe-2S] domain
b3367	316407.85676673	8.8e-150	536.2	Escherichia	nirC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02598					ko00000,ko02000	1.A.16.3			Escherichia	1NBAQ@1224,1RNT4@1236,3XN3M@561,COG2116@1,COG2116@2	NA|NA|NA	P	Catalyzes nitrite uptake and nitrite export across the cytoplasmic membrane. Is up to 10-fold more active than NarK or NarU in nitrite uptake for subsequent reduction in the cytoplasm by the NirB NirD nitrite reductase
b3368	155864.EDL933_4573	1.2e-260	905.2	Escherichia	cysG	GO:0003674,GO:0003824,GO:0004851,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009628,GO:0016740,GO:0016741,GO:0032259,GO:0050896	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838	Escherichia	1MUI0@1224,1RM9V@1236,3XP4Y@561,COG0007@1,COG0007@2,COG1648@1,COG1648@2	NA|NA|NA	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
b3369	155864.EDL933_4574	1.2e-24	118.2	Escherichia	yhfL												Escherichia	1NC5P@1224,1SEQS@1236,2E4XM@1,32ZRK@2,3XQ4T@561	NA|NA|NA	S	Protein of unknown function (DUF4223)
b3370	316407.85676670	7.6e-247	859.4	Escherichia	frlA	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006082,GO:0006520,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0030389,GO:0030392,GO:0030393,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0046395,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098656,GO:1901135,GO:1901136,GO:1901281,GO:1901564,GO:1901565,GO:1901575,GO:1902475,GO:1903825,GO:1905039		ko:K19540					ko00000,ko02000	2.A.3.8.17		iAF1260.b3370,iB21_1397.B21_03173,iBWG_1329.BWG_3062,iEC042_1314.EC042_3632,iEC55989_1330.EC55989_3776,iECBD_1354.ECBD_0378,iECB_1328.ECB_03221,iECDH10B_1368.ECDH10B_3546,iECDH1ME8569_1439.ECDH1ME8569_3250,iECD_1391.ECD_03221,iECIAI1_1343.ECIAI1_3509,iECO111_1330.ECO111_4180,iECO26_1355.ECO26_4459,iETEC_1333.ETEC_3621,iEcDH1_1363.EcDH1_0342,iJO1366.b3370,iSSON_1240.SSON_3502,iUMNK88_1353.UMNK88_4136,iY75_1357.Y75_RS20365	Escherichia	1MXNJ@1224,1RY8P@1236,3XQUA@561,COG0531@1,COG0531@2	NA|NA|NA	E	Is likely involved in the transport of fructoselysine and psicoselysine to the cytoplasm, where they are degraded
b3371	198214.SF3390	6.3e-201	706.4	Gammaproteobacteria													Escherichia	1Q9B7@1224,1RS9I@1236,COG2222@1,COG2222@2	NA|NA|NA	M	Catalyzes the reversible conversion of fructoselysine 6- phosphate to glucose 6-phosphate and lysine. Functions in a fructoselysine degradation pathway that allows E.coli to grow on fructoselysine or psicoselysine
b4474	316407.85676668	3.6e-162	577.4	Escherichia	frlC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006040,GO:0008150,GO:0008152,GO:0009056,GO:0016853,GO:0016854,GO:0016857,GO:0042802,GO:0046348,GO:0071704,GO:1901135,GO:1901136,GO:1901575		ko:K10709					ko00000			iECO111_1330.ECO111_4182	Escherichia	1Q64Z@1224,1S19D@1236,3XQPT@561,COG1082@1,COG1082@2	NA|NA|NA	G	Catalyzes the reversible interconversion of fructoselysine with its C-3 epimer, psicoselysine. Allows E.coli to utilize psicoselysine for growth. Does not act on psicose or fructoselysine 6-phosphate
b3374	316407.85676667	1.2e-154	552.4	Escherichia	frlD	GO:0003674,GO:0003824,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0071704	2.7.1.218	ko:K10710			R08124	RC00002,RC00017	ko00000,ko01000			iETEC_1333.ETEC_3624	Escherichia	1R6C2@1224,1RWC9@1236,3XQAZ@561,COG0524@1,COG0524@2	NA|NA|NA	F	Catalyzes the ATP-dependent phosphorylation of fructoselysine to fructoselysine 6-phosphate. Functions in a fructoselysine degradation pathway that allows E.coli to grow on fructoselysine or psicoselysine. To a much lesser extenst, is also able to phosphorylate psicoselysine
b3375	316407.85676666	2e-137	495.0	Escherichia	frlR	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K10711					ko00000,ko03000				Escherichia	1MZ1G@1224,1RPRE@1236,3XQ7D@561,COG2188@1,COG2188@2	NA|NA|NA	K	May regulate the transcription of the frlABCDR operon, involved in the utilization of fructoselysine and psicoselysine
b3376	316407.85676665	5.3e-198	696.8	Escherichia	yhfS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607											Escherichia	1Q22V@1224,1S07H@1236,3XPA6@561,COG0626@1,COG0626@2	NA|NA|NA	E	O-acetylhomoserine aminocarboxypropyltransferase activity
b3377	316407.85676664	9.7e-231	805.8	Escherichia	yhfT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1QMHW@1224,1RQ8K@1236,2CGY9@1,2Z8E9@2,3XQ6T@561	NA|NA|NA	S	Protein of unknown function
b3378	198214.SF3396	3.1e-59	234.2	Gammaproteobacteria													Escherichia	1RHR3@1224,1T660@1236,2CDRP@1,32N2F@2	NA|NA|NA	S	Protein of unknown function DUF2620
b3379	316407.85676662	1.5e-166	592.0	Escherichia	php	GO:0003674,GO:0005488,GO:0008270,GO:0043167,GO:0043169,GO:0046872,GO:0046914		ko:K07048					ko00000				Escherichia	1NPYS@1224,1RRE8@1236,3XN00@561,COG1735@1,COG1735@2	NA|NA|NA	S	Its real enzymatic activity is not yet known. It was tested for general esterase, aminopeptidase, sulfatase, phosphatase, carbonic anhydrase, phosphodiesterase, and phosphotriesterase activities with the following substrates p- nitrophenyl acetate, L-alanine nitroanilide, p-nitrophenyl sulfate, bis(p-nitrophenyl) phosphate, paraoxon, and p-nitrophenyl phosphate. No enzymatic activity was detected with any of these non-specific substrates
b3380	316407.85676661	3.8e-237	827.0	Escherichia	yhfW	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008973,GO:0016853,GO:0016866,GO:0016868,GO:0044424,GO:0044444,GO:0044464										iAPECO1_1312.APECO1_3083,iECED1_1282.ECED1_4038,iECOK1_1307.ECOK1_3793,iECS88_1305.ECS88_3765,iEcE24377_1341.EcE24377A_3849,iUMN146_1321.UM146_16955,iUTI89_1310.UTI89_C3878	Escherichia	1R4RD@1224,1RRD0@1236,3XN30@561,COG1015@1,COG1015@2	NA|NA|NA	G	phosphopentomutase activity
b3381	316407.85676660	8.6e-223	779.2	Escherichia	yhfX												Escherichia	1QJTS@1224,1RQWY@1236,3XN0G@561,COG3457@1,COG3457@2	NA|NA|NA	E	Alanine racemase, N-terminal domain
b3382	316407.85676659	9e-62	242.7	Escherichia	yhfY												Escherichia	1N0D7@1224,1S8TE@1236,2C4HW@1,32T80@2,3XPTF@561	NA|NA|NA	S	regulation of nucleic acid-templated transcription
b3383	316407.85676658	2.8e-168	597.8	Escherichia	yhfZ												Escherichia	1PKNV@1224,1RS6T@1236,3XM6I@561,COG2188@1,COG2188@2	NA|NA|NA	K	YhfZ C-terminal domain
b3384	316407.85676657	4.4e-191	673.7	Escherichia	trpS	GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF1260.b3384,iB21_1397.B21_03188,iBWG_1329.BWG_3075,iEC042_1314.EC042_3645,iECBD_1354.ECBD_0363,iECB_1328.ECB_03236,iECDH10B_1368.ECDH10B_3559,iECDH1ME8569_1439.ECDH1ME8569_3263,iECD_1391.ECD_03236,iECUMN_1333.ECUMN_3842,iECW_1372.ECW_m3639,iEKO11_1354.EKO11_0361,iEcDH1_1363.EcDH1_0329,iEcHS_1320.EcHS_A3580,iEcolC_1368.EcolC_0329,iJO1366.b3384,iLF82_1304.LF82_2316,iNRG857_1313.NRG857_16750,iUMNK88_1353.UMNK88_4150,iWFL_1372.ECW_m3639,iY75_1357.Y75_RS20300	Escherichia	1MV4T@1224,1RNDC@1236,3XPGI@561,COG0180@1,COG0180@2	NA|NA|NA	J	Belongs to the class-I aminoacyl-tRNA synthetase family
b3385	316407.85676656	1.1e-141	509.2	Escherichia	gph	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0031404,GO:0033554,GO:0034641,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130		R01334	RC00017	ko00000,ko00001,ko01000			iSBO_1134.SBO_3372,iSbBS512_1146.SbBS512_E3762	Escherichia	1RDDY@1224,1S3QD@1236,3XMWS@561,COG0546@1,COG0546@2	NA|NA|NA	F	Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress
b3386	155864.EDL933_4584	1.6e-123	448.7	Escherichia	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008198,GO:0009056,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046872,GO:0046914,GO:0071704,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000				Escherichia	1MUZM@1224,1RN3K@1236,3XNQC@561,COG0036@1,COG0036@2	NA|NA|NA	F	Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate
b3387	155864.EDL933_4585	3.4e-160	570.9	Escherichia	dam	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006281,GO:0006298,GO:0006304,GO:0006305,GO:0006306,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009007,GO:0009008,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0022402,GO:0032259,GO:0032775,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043412,GO:0043414,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044728,GO:0044786,GO:0044787,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901576,GO:1901681,GO:1902292,GO:1902328,GO:1904047	2.1.1.72	ko:K06223	ko03430,map03430				ko00000,ko00001,ko01000,ko02048,ko03032,ko03400				Escherichia	1P85S@1224,1RMNW@1236,3XMRF@561,COG0338@1,COG0338@2	NA|NA|NA	L	Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication
b3388	316407.85676653	1e-144	520.0	Escherichia	damX	GO:0003674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0030428,GO:0032153,GO:0042834,GO:0044464,GO:0097367		ko:K03112					ko00000				Escherichia	1Q1YI@1224,1RRJF@1236,3XMJJ@561,COG3266@1,COG3266@2	NA|NA|NA	D	Cell division protein DamX
b3389	316407.85676652	1.6e-202	711.8	Escherichia	aroB	GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000			iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275	Escherichia	1MUBK@1224,1RN4I@1236,3XNNQ@561,COG0337@1,COG0337@2	NA|NA|NA	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
b3390	155864.EDL933_4588	1.1e-89	335.9	Escherichia	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000				Escherichia	1MUFJ@1224,1RPF6@1236,3XP1J@561,COG0703@1,COG0703@2	NA|NA|NA	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
b3391	316407.85676650	8.3e-224	782.7	Escherichia	hofQ	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575		ko:K02507					ko00000,ko02044				Escherichia	1QTT6@1224,1RN3Z@1236,3XPCW@561,COG4796@1,COG4796@2	NA|NA|NA	U	Required for the use of extracellular DNA as a nutrient. Could be the porin responsible for transport of DNA across the outer membrane
b3392	316407.85676649	8.8e-74	282.7	Escherichia	hofP	GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K12291					ko00000,ko02044				Escherichia	1N98X@1224,1SEDR@1236,2EBIY@1,335JD@2,3XPR6@561	NA|NA|NA	S	carbon utilization
b3393	316407.85676648	7.9e-68	263.1	Escherichia	hofO	GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K12290					ko00000,ko02044				Escherichia	1N5KZ@1224,1S9X7@1236,2CD7R@1,32UHA@2,3XPUZ@561	NA|NA|NA	S	carbon utilization
b3394	198214.SF3412	1.3e-75	289.3	Gammaproteobacteria													Escherichia	1ND6V@1224,1SC9M@1236,COG3166@1,COG3166@2	NA|NA|NA	NU	carbon utilization
b3395	316407.85676646	2.3e-147	528.1	Escherichia	hofM	GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K12288					ko00000,ko02044				Escherichia	1RK2D@1224,1RQWR@1236,3XPHT@561,COG4972@1,COG4972@2	NA|NA|NA	NU	carbon utilization
b3396	316407.85676645	0.0	1699.1	Escherichia	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501				ko00000,ko00001,ko01000,ko01003,ko01011		GT51		Escherichia	1MU5A@1224,1RM7J@1236,3XP4D@561,COG5009@1,COG5009@2	NA|NA|NA	M	penicillin-binding protein 1A
b3397	316407.85676644	3.4e-100	370.9	Escherichia	nudE	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872		ko:K08312	ko00230,map00230		R01054	RC00002	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_3067,iE2348C_1286.E2348C_3641,iECABU_c1320.ECABU_c38150,iECED1_1282.ECED1_4056,iECNA114_1301.ECNA114_3494,iECOK1_1307.ECOK1_3810,iECP_1309.ECP_3483,iECS88_1305.ECS88_3783,iECSF_1327.ECSF_3218,iLF82_1304.LF82_1531,iNRG857_1313.NRG857_16815,iUMN146_1321.UM146_17040,iUTI89_1310.UTI89_C3895,ic_1306.c4167	Escherichia	1RCX7@1224,1S3ZE@1236,3XMNF@561,COG0494@1,COG0494@2	NA|NA|NA	L	ADP compounds hydrolase nudE
b3398	316407.85676643	0.0	1422.1	Escherichia	yrfF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1N39T@1224,1RN16@1236,28IJR@1,2Z8KK@2,3XN1H@561	NA|NA|NA	S	Intracellular growth attenuator protein IgaA
b3399	155864.EDL933_4598	1.4e-129	468.8	Escherichia	yrfG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000				Escherichia	1NH15@1224,1RP27@1236,3XN3E@561,COG1011@1,COG1011@2	NA|NA|NA	S	GMP 5'-nucleotidase activity
b3400	155864.EDL933_4599	2.3e-66	258.1	Escherichia	hslR	GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009987,GO:0016070,GO:0033554,GO:0034605,GO:0034641,GO:0043021,GO:0043023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K04762					ko00000,ko03110				Escherichia	1MZR6@1224,1S8VU@1236,3XPKG@561,COG1188@1,COG1188@2	NA|NA|NA	J	Involved in the recycling of free 50S ribosomal subunits that still carry a nascent chain. Binds RNA more specifically than DNA. Binds with very high affinity to the free 50S ribosomal subunit. Does not bind it when it is part of the 70S ribosome
b3401	155864.EDL933_4600	1e-167	595.9	Escherichia	hslO	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0031647,GO:0036506,GO:0042026,GO:0042802,GO:0043167,GO:0043169,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0065007,GO:0065008		ko:K04083					ko00000,ko03110				Escherichia	1MUMU@1224,1RMP3@1236,3XP30@561,COG1281@1,COG1281@2	NA|NA|NA	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
b3402	316407.85676639	0.0	1110.9	Escherichia	yhgE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1QU1G@1224,1RSNB@1236,3XQJR@561,COG3449@1,COG3449@2	NA|NA|NA	L	Domain of unknown function (DUF4153)
b3403	316407.85676638	0.0	1115.5	Escherichia	pckA	GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000			iSF_1195.SF3422,iUTI89_1310.UTI89_C3903	Escherichia	1MWXN@1224,1RPM0@1236,3XMXQ@561,COG1866@1,COG1866@2	NA|NA|NA	F	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
b3404	198214.SF3423	2e-255	887.9	Gammaproteobacteria													Escherichia	1MUAK@1224,1RPP2@1236,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
b3405	1006000.GKAS_00792	9.7e-132	476.1	Gammaproteobacteria													Escherichia	1MY3D@1224,1RPKN@1236,COG0745@1,COG0745@2	NA|NA|NA	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
b3406	316407.85676635	8.2e-87	326.2	Escherichia	greB	GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010604,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031437,GO:0031439,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903311,GO:1903313,GO:1903506,GO:2000112,GO:2001141		ko:K04760					ko00000,ko03021				Escherichia	1RAP0@1224,1S40Q@1236,3XP87@561,COG0782@1,COG0782@2	NA|NA|NA	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length
b3407	316407.85676634	0.0	1511.5	Escherichia	yhgF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896		ko:K06959					ko00000				Escherichia	1MUA7@1224,1RMNH@1236,3XMBH@561,COG2183@1,COG2183@2	NA|NA|NA	K	response to ionizing radiation
b3408	1440052.EAKF1_ch2556c	1.3e-34	151.8	Escherichia	feoA	GO:0000041,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015684,GO:0030001,GO:0033554,GO:0034220,GO:0034755,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070627,GO:0070838,GO:0072511,GO:0097286,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098707,GO:0098711,GO:0098739,GO:0099587,GO:1903874		ko:K04758					ko00000,ko02000				Escherichia	1N8ZJ@1224,1S9TZ@1236,3XQ0E@561,COG1918@1,COG1918@2	NA|NA|NA	P	Ferrous iron transport protein A
b3409	316407.85676632	0.0	1490.7	Escherichia	feoB	GO:0000041,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005215,GO:0005381,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006950,GO:0006974,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015093,GO:0015318,GO:0015684,GO:0016020,GO:0017076,GO:0019001,GO:0022857,GO:0022890,GO:0030001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033554,GO:0034220,GO:0034755,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070838,GO:0071944,GO:0072509,GO:0072511,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1903874		ko:K04759					ko00000,ko02000	9.A.8.1		iECs_1301.ECs4251	Escherichia	1MUZC@1224,1RME9@1236,3XNS0@561,COG0370@1,COG0370@2	NA|NA|NA	P	Transporter of a GTP-driven Fe(2 ) uptake system
b3410	155864.EDL933_4611	1.1e-36	158.7	Escherichia	feoC			ko:K07490					ko00000,ko02000				Escherichia	1N73I@1224,1SDB1@1236,2E630@1,330S2@2,3XQ4D@561	NA|NA|NA	K	May function as a transcriptional regulator that controls feoABC expression
b3411	316407.85676630	1.1e-164	585.9	Gammaproteobacteria													Escherichia	1MUSP@1224,1RNUW@1236,COG5464@1,COG5464@2	NA|NA|NA	S	Transposase
b3412	316407.85676629	3.9e-147	527.3	Escherichia	bioH	GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016787,GO:0016788,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:0072330,GO:0090499,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000			iBWG_1329.BWG_3103,iECBD_1354.ECBD_0333,iECDH10B_1368.ECDH10B_3587,iECDH1ME8569_1439.ECDH1ME8569_3291,iETEC_1333.ETEC_3662,iEcDH1_1363.EcDH1_0301,iJO1366.b3412,iY75_1357.Y75_RS20155	Escherichia	1QUBR@1224,1RSF9@1236,3XMUP@561,COG0596@1,COG0596@2	NA|NA|NA	S	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters
b3413	316407.85676628	3e-130	471.1	Escherichia	gntX	GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575											Escherichia	1RHAV@1224,1S64Q@1236,3XMCJ@561,COG1040@1,COG1040@2	NA|NA|NA	S	DNA utilization protein
b3414	1440052.EAKF1_ch2549c	3.6e-105	387.5	Escherichia	gntY	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0010467,GO:0015976,GO:0016043,GO:0016226,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0050896,GO:0051186,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0097428,GO:0098771,GO:1901564		ko:K07400					ko00000				Escherichia	1MU8Y@1224,1RN7J@1236,3XNB4@561,COG0316@1,COG0316@2,COG0694@1,COG0694@2	NA|NA|NA	O	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
b3415	199310.c4192	1.2e-223	782.3	Escherichia	gntT	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015128,GO:0015144,GO:0015318,GO:0015711,GO:0015718,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0035429,GO:0042873,GO:0042879,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K06155					ko00000,ko02000	2.A.8.1.4		iSSON_1240.SSON_3547	Escherichia	1MUFG@1224,1RNGE@1236,3XNJE@561,COG2610@1,COG2610@2	NA|NA|NA	P	gluconate transporter
b3416	316407.85676625	0.0	1450.3	Escherichia	malQ	GO:0000023,GO:0000025,GO:0003674,GO:0003824,GO:0004133,GO:0004134,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005984,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0055114,GO:0071704,GO:1901575	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100		R05196	RC00049	ko00000,ko00001,ko01000		GH77	iECIAI1_1343.ECIAI1_3560,iECO111_1330.ECO111_4225,iECO26_1355.ECO26_4504,iEcE24377_1341.EcE24377A_3892,iUMNK88_1353.UMNK88_4184	Escherichia	1QTVJ@1224,1RMJW@1236,3XP9K@561,COG1640@1,COG1640@2	NA|NA|NA	G	beta-maltose 4-alpha-glucanotransferase activity
b3417	316407.85676624	0.0	1633.6	Escherichia	malP	GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0030978,GO:0030980,GO:0031220,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931		R02111		ko00000,ko00001,ko01000		GT35	iECNA114_1301.ECNA114_3525	Escherichia	1MW4J@1224,1RN8P@1236,3XMMY@561,COG0058@1,COG0058@2	NA|NA|NA	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
b3418	316407.85676623	0.0	1780.0	Escherichia	malT	GO:0003674,GO:0005488,GO:0005515,GO:0030246,GO:0042802,GO:0048031,GO:0070492		ko:K03556					ko00000,ko03000				Escherichia	1MVZZ@1224,1RN29@1236,3XN8M@561,COG2909@1,COG2909@2	NA|NA|NA	K	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA TG GA-3'
b4475	316407.85676622	3.3e-186	657.5	Escherichia	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098	6.5.1.4	ko:K01974					ko00000,ko01000				Escherichia	1MX7Q@1224,1RSFF@1236,3XMP7@561,COG0430@1,COG0430@2	NA|NA|NA	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
b3421	316407.85676621	3.2e-236	823.9	Escherichia	rtcB	GO:0003674,GO:0003824,GO:0003909,GO:0005488,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0030145,GO:0033554,GO:0034641,GO:0042245,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:0140098,GO:1901360	6.5.1.3	ko:K14415					ko00000,ko01000,ko03016				Escherichia	1MUHA@1224,1RMXH@1236,3XMBB@561,COG1690@1,COG1690@2	NA|NA|NA	S	RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. Probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester, a step that requires GTP. Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-PO4 (or cyclic-PO4) and 5'-OH ends that cannot be sealed by classical DNA ligases
b3422	316407.85676620	3.2e-308	1063.5	Escherichia	rtcR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K14414					ko00000,ko03000				Escherichia	1MX6U@1224,1RS3H@1236,3XNMV@561,COG4650@1,COG4650@2	NA|NA|NA	K	Transcriptional regulatory protein RtcR
b3423	1440052.EAKF1_ch2541	2.5e-18	99.4	Escherichia	glpR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02444					ko00000,ko03000				Escherichia	1MUJG@1224,1RPS0@1236,3XPF7@561,COG1349@1,COG1349@2	NA|NA|NA	K	Glycerol-3-phosphate regulon repressor
b3424	199310.c4201	7.2e-155	553.1	Escherichia	glpG	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:0140096,GO:1901363,GO:1901564,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K02441					ko00000				Escherichia	1MYPM@1224,1RN1K@1236,3XMTF@561,COG0705@1,COG0705@2	NA|NA|NA	S	Rhomboid-type serine protease that catalyzes intramembrane proteolysis
b3425	198214.SF3447	2.7e-57	227.6	Gammaproteobacteria													Escherichia	1MZPW@1224,1S94C@1236,COG0607@1,COG0607@2	NA|NA|NA	P	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide
b3426	316407.85676616	4e-297	1026.5	Escherichia	glpD	GO:0000166,GO:0003674,GO:0003824,GO:0004368,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006072,GO:0006091,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009331,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016901,GO:0019637,GO:0022900,GO:0031224,GO:0031226,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046168,GO:0046434,GO:0048037,GO:0050660,GO:0050662,GO:0052590,GO:0052646,GO:0055114,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:1901135,GO:1901136,GO:1901265,GO:1901363,GO:1901575,GO:1902494,GO:1990204	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110		R00848	RC00029	ko00000,ko00001,ko01000			iSSON_1240.SSON_3663	Escherichia	1MUMY@1224,1RMGP@1236,3XMEJ@561,COG0578@1,COG0578@2	NA|NA|NA	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
b3427	316407.85676615	1.1e-41	175.6	Gammaproteobacteria													Escherichia	1NZ5S@1224,1SQJ7@1236,COG0226@1,COG0226@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import
b3428	198214.SF3451	0.0	1652.5	Gammaproteobacteria													Escherichia	1MW4J@1224,1RN8P@1236,COG0058@1,COG0058@2	NA|NA|NA	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
b3429	155864.EDL933_4635	1.1e-280	971.8	Escherichia	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003		GT5	iSFV_1184.SFV_3438	Escherichia	1MUGM@1224,1RNMP@1236,3XP2P@561,COG0297@1,COG0297@2	NA|NA|NA	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose
b3430	155864.EDL933_4636	2.3e-248	864.4	Escherichia	glgC	GO:0000166,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016043,GO:0016051,GO:0016208,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0022607,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046872,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070566,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_3027,iUTI89_1310.UTI89_C3939	Escherichia	1MVTC@1224,1RP04@1236,3XP6K@561,COG0448@1,COG0448@2	NA|NA|NA	F	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
b3431	316407.85676611	0.0	1410.6	Escherichia	glgX	GO:0000272,GO:0003674,GO:0003824,GO:0004133,GO:0004135,GO:0004553,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015926,GO:0015980,GO:0016052,GO:0016787,GO:0016798,GO:0033554,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0090599,GO:1901575	3.2.1.196	ko:K02438	ko00500,ko01100,map00500,map01100		R02111		ko00000,ko00001,ko01000		CBM48,GH13	iEcHS_1320.EcHS_A3631,iEcolC_1368.EcolC_0281	Escherichia	1MU19@1224,1RP6F@1236,3XNET@561,COG1523@1,COG1523@2	NA|NA|NA	G	Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin
b3432	316407.85676610	0.0	1567.4	Escherichia	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110		ko00000,ko00001,ko00002,ko01000,ko04147		CBM48,GH13	iAPECO1_1312.APECO1_3025,iECNA114_1301.ECNA114_3542,iECOK1_1307.ECOK1_3857,iECS88_1305.ECS88_3830,iECSF_1327.ECSF_3253,iLF82_1304.LF82_0837,iNRG857_1313.NRG857_17030,iUTI89_1310.UTI89_C3941	Escherichia	1QTVN@1224,1RQSK@1236,3XMP5@561,COG0296@1,COG0296@2	NA|NA|NA	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
b3433	155864.EDL933_4639	5e-212	743.4	Escherichia	asd	GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0033554,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_3527	Escherichia	1MUHG@1224,1RMN3@1236,3XMDB@561,COG0136@1,COG0136@2	NA|NA|NA	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
b3434	155864.EDL933_4640	9.2e-96	356.3	Escherichia	yhgN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1N689@1224,1RPV0@1236,3XMAM@561,COG2095@1,COG2095@2	NA|NA|NA	U	MarC family integral membrane protein
b4476	155864.EDL933_4646	6.9e-240	836.3	Escherichia	gntU	GO:0003674,GO:0005215,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0015075,GO:0015144,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655		ko:K06156					ko00000,ko02000	2.A.8.1.8		iAF1260.b4476,iB21_1397.B21_03240,iBWG_1329.BWG_3127,iEC55989_1330.EC55989_3845,iECB_1328.ECB_03287,iECDH10B_1368.ECDH10B_3609,iECDH1ME8569_1439.ECDH1ME8569_3313,iECD_1391.ECD_03287,iECH74115_1262.ECH74115_4752,iECIAI1_1343.ECIAI1_3581,iECIAI39_1322.ECIAI39_3918,iECO26_1355.ECO26_4525,iECSE_1348.ECSE_3704,iECSP_1301.ECSP_4391,iECUMN_1333.ECUMN_3899,iECs_1301.ECs4285,iEKO11_1354.EKO11_0306,iETEC_1333.ETEC_3684,iEcDH1_1363.EcDH1_0279,iEcE24377_1341.EcE24377A_3914,iEcHS_1320.EcHS_A3635,iEcSMS35_1347.EcSMS35_3719,iEcolC_1368.EcolC_0277,iG2583_1286.G2583_4138,iJO1366.b4476,iSDY_1059.SDY_3587,iUMNK88_1353.UMNK88_4205,iY75_1357.Y75_RS20045,iZ_1308.Z4804	Escherichia	1MUFG@1224,1RNGE@1236,3XMJC@561,COG2610@1,COG2610@2	NA|NA|NA	P	Low-affinity gluconate
b3437	316407.85676606	3.4e-94	350.9	Escherichia	gntK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0046316	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200		R01737	RC00002,RC00017	ko00000,ko00001,ko01000			iUTI89_1310.UTI89_C3945	Escherichia	1RHD0@1224,1RP41@1236,3XN1N@561,COG3265@1,COG3265@2	NA|NA|NA	F	gluconokinase activity
b3438	199310.c4227	8e-185	652.9	Escherichia	gntR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K06145					ko00000,ko03000				Escherichia	1MUEP@1224,1RQKH@1236,3XNR3@561,COG1609@1,COG1609@2	NA|NA|NA	K	Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon
b3439	316407.85676604	8.4e-133	479.6	Escherichia	yhhW	GO:0003674,GO:0003824,GO:0008127,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0051213,GO:0055114		ko:K06911					ko00000				Escherichia	1MVSW@1224,1RNVS@1236,3XMG6@561,COG1741@1,COG1741@2	NA|NA|NA	S	however, may provide a mechanism that would avoid inhibition of key cellular proteins, such as DNA gyrase, by quercetin
b3440	316407.85676603	4.4e-202	710.3	Escherichia	yhhX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1NHXV@1224,1RZPJ@1236,3XN06@561,COG0673@1,COG0673@2	NA|NA|NA	S	oxidoreductase activity
b3441	316407.85676602	1.5e-91	342.0	Escherichia	yhhY	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234		ko:K03825					ko00000,ko01000				Escherichia	1QUGY@1224,1T1YJ@1236,3XP7U@561,COG1247@1,COG1247@2	NA|NA|NA	M	Catalyzes the N-acetylation of L-phenylalanine and L- methionine using acetyl-CoA as acetyl donor in vitro. Cannot accept L-tyrosine as substrate and propionyl-CoA, succinyl-CoA or (S)-methylmalonyl-CoA as acyl donors. Is also able to acetylate and thus detoxify several nonhydrolyzable aminoacyl adenylates, but not the processed form of the peptide- nucleotide antibiotic microcin C (McC). When overproduced, provides complete resistance to leucyl sulfamoyl adenylate (LSA) and partial resistance to alanyl sulfamoyl adenylate (ASA) and phenylalanyl sulfamoyl adenylate (FSA). Therefore, may protect bacteria from various toxic aminoacyl nucleotides, either exogenous or those generated inside the cell during normal metabolism
b3442	316407.85676601	6.1e-224	783.1	Escherichia	yhhZ			ko:K06887					ko00000				Escherichia	1RB0U@1224,1S2CP@1236,3XR91@561,COG3157@1,COG3157@2	NA|NA|NA	S	Type VI secretion system effector, Hcp
b3443	316407.85676600	1.2e-67	262.3	Gammaproteobacteria													Escherichia	1RFEN@1224,1S549@1236,292QA@1,2ZQ83@2	NA|NA|NA		
b3444	1035839.AFNK01000018_gene1622	9e-46	189.1	Gammaproteobacteria													Escherichia	1NP8S@1224,1SDQB@1236,COG3677@1,COG3677@2	NA|NA|NA	L	PFAM Insertion element protein
b3445	177439.DP0860	5.6e-94	350.1	Proteobacteria													Escherichia	1NHAK@1224,COG1662@1,COG1662@2	NA|NA|NA	L	cog cog1662
b3446	316407.85676597	6.2e-50	203.0	Gammaproteobacteria													Escherichia	1N6EH@1224,1SBUZ@1236,2EHFB@1,32TBX@2	NA|NA|NA	S	Immunity protein 35
b3447	316407.85676596	0.0	1150.6	Escherichia	ggt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100		R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002			iAPECO1_1312.APECO1_3012,iECOK1_1307.ECOK1_3869,iECS88_1305.ECS88_3844,iECW_1372.ECW_m3706,iEKO11_1354.EKO11_0296,iETEC_1333.ETEC_3693,iUMN146_1321.UM146_17325,iUTI89_1310.UTI89_C3954,iWFL_1372.ECW_m3706	Escherichia	1MUV6@1224,1RMIT@1236,3XN4W@561,COG0405@1,COG0405@2	NA|NA|NA	M	it may function in amino acid uptake salvage, or possibly in peptidoglycan linkage. Catalyzes the hydrolysis and transpeptidation of many gamma-glutamyl compounds (including some D-gamma-glutamyl substrates), with a preference for basic and aromatic amino acids as acceptors. The KM values for gamma-glutamyl acceptors are so high that it has been proposed transpeptidation is not the physiological role in E.coli
b3448	198214.SF3465	6.5e-38	163.7	Gammaproteobacteria													Escherichia	1N0WI@1224,1SAJI@1236,2D4KK@1,32THA@2	NA|NA|NA	S	Protein of unknown function (DUF2756)
b3449	316407.85676594	6.7e-144	516.5	Escherichia	ugpQ	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0008081,GO:0008889,GO:0016787,GO:0016788,GO:0042578,GO:0043167,GO:0043169,GO:0046872,GO:0047389,GO:0047395	3.1.4.46	ko:K01126	ko00564,map00564		R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000			iEC042_1314.EC042_3710,iEC55989_1330.EC55989_3857	Escherichia	1MU8H@1224,1RQWX@1236,3XNM9@561,COG0584@1,COG0584@2	NA|NA|NA	C	glycerophosphoryl diester phosphodiesterase
b3450	316407.85676593	2.7e-202	711.1	Escherichia	ugpC	GO:0000166,GO:0001406,GO:0001407,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008144,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015399,GO:0015405,GO:0015430,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098656,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.20	ko:K05816	ko02010,map02010	M00198			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.3		iAF1260.b3450,iB21_1397.B21_03252,iBWG_1329.BWG_3141,iECABU_c1320.ECABU_c38800,iECB_1328.ECB_03299,iECDH10B_1368.ECDH10B_3624,iECD_1391.ECD_03299,iETEC_1333.ETEC_3696,iJO1366.b3450,iJR904.b3450,iUMNK88_1353.UMNK88_4218,iY75_1357.Y75_RS19980,ic_1306.c4239	Escherichia	1MU3I@1224,1RM9E@1236,3XPDF@561,COG3842@1,COG3842@2	NA|NA|NA	P	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system
b3451	316407.85676592	4.9e-151	540.4	Escherichia	ugpE	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0032991,GO:0034220,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098656,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K05815	ko02010,map02010	M00198			ko00000,ko00001,ko00002,ko02000	3.A.1.1.3		iLF82_1304.LF82_2362,iNRG857_1313.NRG857_17110	Escherichia	1MUWS@1224,1RMKG@1236,3XNKK@561,COG0395@1,COG0395@2	NA|NA|NA	G	probably responsible for the translocation of the substrate across the membrane
b3452	316407.85676591	1.4e-159	568.9	Escherichia	ugpA	GO:0001406,GO:0001407,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0032991,GO:0034220,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098656,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K05814	ko02010,map02010	M00198			ko00000,ko00001,ko00002,ko02000	3.A.1.1.3		iSFxv_1172.SFxv_3786	Escherichia	1MVAP@1224,1RNQF@1236,3XM4S@561,COG1175@1,COG1175@2	NA|NA|NA	G	probably responsible for the translocation of the substrate across the membrane
b3453	155864.EDL933_4660	2.5e-258	897.5	Escherichia	ugpB	GO:0001407,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0015748,GO:0015794,GO:0030288,GO:0030313,GO:0031975,GO:0034220,GO:0042597,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:1901264		ko:K05813	ko02010,map02010	M00198			ko00000,ko00001,ko00002,ko02000	3.A.1.1.3		iEcE24377_1341.EcE24377A_3931	Escherichia	1MVMW@1224,1RRH3@1236,3XMXF@561,COG1653@1,COG1653@2	NA|NA|NA	P	Sn-glycerol-3-phosphate and glycerophosphoryl diester- binding protein interacts with the binding protein-dependent transport system UgpACE
b3454	316407.85676589	2.9e-128	464.5	Escherichia	livF	GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008144,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015188,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:0098655,GO:0098656,GO:1901265,GO:1901363,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039		ko:K01996	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4		iAPECO1_1312.APECO1_3005,iECs_1301.ECs4301,iSSON_1240.SSON_3692,iUTI89_1310.UTI89_C3961,iZ_1308.Z4824	Escherichia	1MVVC@1224,1RMK8@1236,3XNKA@561,COG0410@1,COG0410@2	NA|NA|NA	P	High-affinity branched-chain amino acid transport ATP-binding protein
b3455	155864.EDL933_4665	4.2e-141	507.3	Escherichia	livG	GO:0000166,GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005488,GO:0005524,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008144,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:0098655,GO:0098656,GO:1901265,GO:1901363,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039		ko:K01995	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4		iECNA114_1301.ECNA114_3561	Escherichia	1MUTY@1224,1RQU2@1236,3XMRQ@561,COG0411@1,COG0411@2	NA|NA|NA	P	High-affinity branched-chain amino acid transport ATP-binding protein livG
b3456	316407.85676587	1.3e-216	758.8	Escherichia	livM	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039		ko:K01998	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4		iSDY_1059.SDY_3605	Escherichia	1MV66@1224,1RPTT@1236,3XMKJ@561,COG4177@1,COG4177@2	NA|NA|NA	P	the binding-protein-dependent transport system
b3457	1440052.EAKF1_ch2506	1.2e-158	565.8	Escherichia	livH	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039		ko:K01997	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4		iSFV_1184.SFV_3460,iSF_1195.SF3475,iSFxv_1172.SFxv_3791,iS_1188.S4288	Escherichia	1MU25@1224,1RNDV@1236,3XMWM@561,COG0559@1,COG0559@2	NA|NA|NA	E	Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane
b3458	316407.85676585	5.5e-211	740.0	Escherichia	livK	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015820,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705		ko:K01999	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4		iUTI89_1310.UTI89_C3965	Escherichia	1MWJ1@1224,1RP5V@1236,3XP89@561,COG0683@1,COG0683@2	NA|NA|NA	E	This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids in E.coli
b3459	316407.85676584	2.6e-67	261.2	Escherichia	panZ	GO:0006082,GO:0006508,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010467,GO:0015939,GO:0015940,GO:0016053,GO:0016485,GO:0019538,GO:0019752,GO:0031638,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043086,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0050790,GO:0051186,GO:0051188,GO:0051604,GO:0065007,GO:0065009,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576											Escherichia	1RIN3@1224,1S494@1236,3XPJW@561,COG0454@1,COG0456@2	NA|NA|NA	K	Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion
b3460	155864.EDL933_4673	2e-208	731.5	Escherichia	livJ	GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702,GO:0071705		ko:K01999	ko02010,ko02024,map02010,map02024	M00237			ko00000,ko00001,ko00002,ko02000	3.A.1.4		iECNA114_1301.ECNA114_3569,iECSF_1327.ECSF_3279,iECs_1301.ECs4309,iEcSMS35_1347.EcSMS35_3743,iG2583_1286.G2583_4163,iSFxv_1172.SFxv_3794,iSSON_1240.SSON_3698,iS_1188.S4285,iZ_1308.Z4834	Escherichia	1MWJ1@1224,1RP5V@1236,3XMH3@561,COG0683@1,COG0683@2	NA|NA|NA	E	This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids
b3461	1440052.EAKF1_ch2494	5.7e-155	553.5	Escherichia	rpoH	GO:0000150,GO:0000976,GO:0000984,GO:0000985,GO:0000988,GO:0000990,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006310,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009009,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031421,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2001141		ko:K03089					ko00000,ko03021				Escherichia	1MVWR@1224,1RMFR@1236,3XM8B@561,COG0568@1,COG0568@2	NA|NA|NA	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes
b3462	198214.SF3480	2.5e-192	677.9	Gammaproteobacteria													Escherichia	1MU65@1224,1RYBV@1236,COG2177@1,COG2177@2	NA|NA|NA	D	Part of the ABC transporter FtsEX involved in cellular division
b3463	155864.EDL933_4676	2e-123	448.4	Escherichia	ftsE	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363		ko:K09812	ko02010,map02010	M00256			ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140			Escherichia	1MVQ4@1224,1RMZA@1236,3XP97@561,COG2884@1,COG2884@2	NA|NA|NA	D	Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring
b3464	316407.85676579	1.9e-190	672.2	Escherichia	ftsY	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019897,GO:0019898,GO:0031224,GO:0031226,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7			Escherichia	1MUDU@1224,1RNIN@1236,3XN2M@561,COG0552@1,COG0552@2	NA|NA|NA	D	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
b3465	199310.c4258	3.3e-109	401.0	Escherichia	rsmD	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.171	ko:K08316			R07234	RC00003	ko00000,ko01000,ko03009				Escherichia	1MXKW@1224,1RN21@1236,3XNX4@561,COG0742@1,COG0742@2	NA|NA|NA	J	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle
b3466	316407.85676577	1.3e-41	175.3	Escherichia	yhhL			ko:K08993					ko00000				Escherichia	1N00W@1224,1SA2V@1236,3XPWX@561,COG3776@1,COG3776@2	NA|NA|NA	S	Protein of unknown function (DUF1145)
b3467	316407.85676576	3.8e-44	184.1	Escherichia	yhhM												Escherichia	1RDRA@1224,1S5XK@1236,2AHZY@1,318D9@2,3XPRJ@561	NA|NA|NA	S	Protein of unknown function (DUF2500)
b3468	198214.SF3486	1.5e-112	412.1	Gammaproteobacteria													Escherichia	1PN0I@1224,1RNUV@1236,COG3714@1,COG3714@2	NA|NA|NA	S	membrane
b3469	316407.85676574	0.0	1346.3	Escherichia	zntA	GO:0000041,GO:0003674,GO:0003824,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0006829,GO:0006950,GO:0008150,GO:0008324,GO:0008551,GO:0009636,GO:0010035,GO:0010038,GO:0010043,GO:0010312,GO:0015075,GO:0015086,GO:0015087,GO:0015094,GO:0015099,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015675,GO:0015691,GO:0015692,GO:0016020,GO:0016021,GO:0016462,GO:0016463,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0035444,GO:0042221,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044464,GO:0046686,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0090662,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0099131,GO:0099132,GO:1990359	3.6.3.3,3.6.3.5	ko:K01534					ko00000,ko01000	3.A.3.6		iLF82_1304.LF82_3723,iNRG857_1313.NRG857_17200,iUMNK88_1353.UMNK88_4239	Escherichia	1MU08@1224,1RN2C@1236,3XM67@561,COG2217@1,COG2217@2	NA|NA|NA	P	Confers resistance to zinc, cadmium and lead. Couples the hydrolysis of ATP with the export of zinc, cadmium or lead, with highest activity when the metals are present as metal-thiolate complexes. Can also bind nickel, copper, cobalt and mercury
b3470	155864.EDL933_4683	2.7e-41	174.1	Escherichia	tusA			ko:K04085	ko04122,map04122				ko00000,ko00001,ko01000,ko03016				Escherichia	1MZA5@1224,1S8TC@1236,3XPXD@561,COG0425@1,COG0425@2	NA|NA|NA	J	Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin
b3471	316407.85676572	4.3e-118	430.6	Escherichia	yhhQ	GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046116,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072531,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1990397		ko:K09125					ko00000				Escherichia	1MVQU@1224,1RNX0@1236,3XN77@561,COG1738@1,COG1738@2	NA|NA|NA	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
b3472	155864.EDL933_4685	3.3e-95	354.4	Escherichia	dcrB	GO:0005575,GO:0005623,GO:0042597,GO:0044464											Escherichia	1MVXI@1224,1RSF1@1236,28J7P@1,2Z932@2,3XN32@561	NA|NA|NA	S	DcrB
b3473	316407.85676570	1.7e-221	775.0	Escherichia	yhhS	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1QUBP@1224,1RUKT@1236,3XM57@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	MFS-type transporter YhhS
b3474	155864.EDL933_4687	3.1e-179	634.4	Escherichia	yhhT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944											Escherichia	1MXXU@1224,1RQCM@1236,3XP7B@561,COG0628@1,COG0628@2	NA|NA|NA	S	transporter activity
b3475	316407.85676568	9.1e-112	409.5	Escherichia	acpT	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006553,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0019878,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607		ko:K06133	ko00770,map00770		R01625	RC00002	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_3584	Escherichia	1MZHC@1224,1SCGA@1236,3XNTQ@561,COG2091@1,COG2091@2	NA|NA|NA	H	May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis in E.coli. The native apo-protein substrate is
b3476	316407.85676567	5e-306	1056.2	Escherichia	nikA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006935,GO:0008150,GO:0009605,GO:0016151,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0040011,GO:0042221,GO:0042330,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050896,GO:0050919,GO:0051540,GO:0097159,GO:1901363		ko:K15584	ko02010,map02010	M00440			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iSFV_1184.SFV_3479	Escherichia	1P1HT@1224,1RQ7Z@1236,3XPAH@561,COG0747@1,COG0747@2	NA|NA|NA	E	periplasmic
b3477	316407.85676566	1.9e-172	611.7	Escherichia	nikB	GO:0000041,GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015099,GO:0015318,GO:0015675,GO:0016020,GO:0016021,GO:0016151,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035444,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K15585	ko02010,map02010	M00440			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iG2583_1286.G2583_4198	Escherichia	1MU8Z@1224,1RP7R@1236,3XMHP@561,COG0601@1,COG0601@2	NA|NA|NA	P	Nickel transport system permease protein NikB
b3478	754331.AEME01000001_gene4104	6.3e-151	540.0	Escherichia	nikC	GO:0000041,GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015099,GO:0015318,GO:0015675,GO:0016020,GO:0016021,GO:0016151,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035444,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K15586	ko02010,map02010	M00440			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iSbBS512_1146.SbBS512_E3843	Escherichia	1NNQQ@1224,1RNGP@1236,3XNXB@561,COG1173@1,COG1173@2	NA|NA|NA	P	Nickel transport system permease protein nikC
b3479	316407.85676564	2.9e-134	484.6	Escherichia	nikD	GO:0000041,GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0015675,GO:0017076,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035444,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0051179,GO:0051234,GO:0055085,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363	3.6.3.24	ko:K15587	ko02010,map02010	M00440			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5		iECIAI39_1322.ECIAI39_3960,iEcSMS35_1347.EcSMS35_3763	Escherichia	1R4F4@1224,1RZNK@1236,3XPEJ@561,COG0444@1,COG0444@2	NA|NA|NA	P	Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
b3480	316407.85676563	1.6e-143	515.4	Escherichia	nikE	GO:0000041,GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0015675,GO:0017076,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034220,GO:0035444,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363	3.6.3.24	ko:K10824	ko02010,map02010	M00440			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5		iAPECO1_1312.APECO1_2974,iE2348C_1286.E2348C_3721,iECABU_c1320.ECABU_c39100,iECED1_1282.ECED1_4153,iECOK1_1307.ECOK1_3909,iECP_1309.ECP_3575,iECS88_1305.ECS88_3883,iUMN146_1321.UM146_17525,iUTI89_1310.UTI89_C3997,ic_1306.c4273	Escherichia	1R3X1@1224,1RMIC@1236,3XM78@561,COG1124@1,COG1124@2	NA|NA|NA	P	Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
b3481	1440052.EAKF1_ch2473c	3.8e-69	267.3	Escherichia	nikR	GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016151,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032991,GO:0032993,GO:0042802,GO:0043167,GO:0043169,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071840,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141		ko:K07722					ko00000,ko03000				Escherichia	1RK4R@1224,1S44Q@1236,3XPMA@561,COG0864@1,COG0864@2	NA|NA|NA	K	Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel
b3482	316407.85676561	0.0	2442.9	Escherichia	rhsB												Escherichia	1MVV1@1224,1SKYM@1236,3XQSX@561,COG3209@1,COG3209@2	NA|NA|NA	M	Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell
b3483	316407.85676560	8.4e-66	256.1	Bacteria													Escherichia	2DRW6@1,33DD7@2	NA|NA|NA	S	NTF2 fold immunity protein
b3484	316407.85676559	1.8e-220	771.5	Escherichia	yhhI												Escherichia	1MXB5@1224,1RSAV@1236,3XQUD@561,COG5433@1,COG5433@2	NA|NA|NA	L	transposase
b3485	198214.SF3501	4.3e-203	713.8	Gammaproteobacteria													Escherichia	1MUIA@1224,1RQSE@1236,COG0842@1,COG0842@2	NA|NA|NA	V	ABC-type multidrug transport system, permease component
b3486	316407.85676557	0.0	1761.1	Escherichia	rbbA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0042623,GO:0043021,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045727,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060187,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1990904,GO:2000112		ko:K13926					ko00000				Escherichia	1QTT9@1224,1T1GD@1236,3XP1H@561,COG0842@1,COG0842@2,COG1129@1,COG1129@2	NA|NA|NA	V	Exhibits an intrinsic ATPase activity that is stimulated by both 70S ribosomes and 30S ribosomal subunits. Could be involved in protein-chain elongation and in release of deacyl-tRNA from ribosomes after peptide bond synthesis. Stimulates the synthesis of polyphenylalanine in vitro
b3487	316407.85676556	9.6e-144	516.5	Escherichia	yhiI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K01993					ko00000				Escherichia	1MUG6@1224,1RS3I@1236,3XP98@561,COG0845@1,COG0845@2	NA|NA|NA	M	protein secretion
b3488	316407.85676555	0.0	1095.9	Gammaproteobacteria													Escherichia	1NRVU@1224,1SKWJ@1236,2F0JS@1,33TNG@2	NA|NA|NA	S	Domain of unknown function (DUF4049)
b4660	469008.B21_03292	1.8e-218	765.4	Gammaproteobacteria													Escherichia	1NU0X@1224,1SKUI@1236,2F0JS@1,33S2G@2	NA|NA|NA	S	Domain of unknown function (DUF4049)
b3491	155864.EDL933_4727	9.3e-192	676.0	Escherichia	yhiM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Escherichia	1NP1K@1224,1TGB4@1236,28KGD@1,2ZA26@2,3XQBH@561	NA|NA|NA	S	Protein of unknown function (DUF2776)
b3492	316407.85676552	1.2e-232	812.0	Escherichia	yhiN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07007					ko00000				Escherichia	1MUGC@1224,1RNCW@1236,3XMPE@561,COG2081@1,COG2081@2	NA|NA|NA	S	HI0933-like protein
b3493	155864.EDL933_4730	1.2e-272	945.3	Escherichia	pitA	GO:0000041,GO:0003674,GO:0005215,GO:0005315,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006817,GO:0006820,GO:0006829,GO:0008150,GO:0008324,GO:0008509,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015654,GO:0015672,GO:0015698,GO:0015710,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1902600		ko:K16322					ko00000,ko02000	2.A.20.1		iECO111_1330.ECO111_4301	Escherichia	1MVXK@1224,1RP0Q@1236,3XMW3@561,COG0306@1,COG0306@2	NA|NA|NA	P	Low-affinity inorganic phosphate transport. Can also transport arsenate
b3494	1440052.EAKF1_ch2466	3.6e-57	227.3	Escherichia	uspB	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009636,GO:0010033,GO:0016020,GO:0042221,GO:0042493,GO:0044464,GO:0045471,GO:0046677,GO:0050896,GO:0071944,GO:0097305,GO:1901700		ko:K06144					ko00000,ko02000	9.B.4.1.1			Escherichia	1RDHD@1224,1S3P8@1236,291H9@1,2ZP3V@2,3XPS7@561	NA|NA|NA	S	response to ethanol
b3495	1114922.CIFAM_12_00790	3.8e-75	287.3	Citrobacter													Escherichia	1MV6Y@1224,1RQQ7@1236,3WV7C@544,COG0589@1,COG0589@2	NA|NA|NA	T	Required for resistance to DNA-damaging agents
b3496	316407.85676548	4e-273	946.8	Escherichia	dtpB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006855,GO:0006857,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015333,GO:0015672,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0035442,GO:0035443,GO:0035672,GO:0035673,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042937,GO:0042938,GO:0042939,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904680		ko:K03305					ko00000	2.A.17		iECH74115_1262.ECH74115_4843,iECSP_1301.ECSP_4476,iECs_1301.ECs4368,iZ_1308.Z4896	Escherichia	1MW6W@1224,1RM8P@1236,3XPF2@561,COG3104@1,COG3104@2	NA|NA|NA	U	Proton-dependent permease that transports di- and tripeptides
b3497	155864.EDL933_4735	6.5e-139	500.0	Escherichia	rsmJ	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036308,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.242	ko:K15984					ko00000,ko01000,ko03009				Escherichia	1MX8Z@1224,1RMIB@1236,3XMKK@561,COG0742@1,COG0742@2	NA|NA|NA	J	Specifically methylates the guanosine in position 1516 of 16S rRNA
b3498	316407.85676546	0.0	1370.9	Escherichia	prlC	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576	3.4.24.70	ko:K01414					ko00000,ko01000,ko01002				Escherichia	1MU1K@1224,1RMAH@1236,3XNTT@561,COG0339@1,COG0339@2	NA|NA|NA	E	May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4)
b3499	316407.85676545	1.2e-160	572.4	Escherichia	yhiR	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0015976,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036307,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.266	ko:K07115					ko00000,ko01000,ko03009				Escherichia	1MWGA@1224,1RNI1@1236,3XMD2@561,COG2961@1,COG2961@2	NA|NA|NA	J	Specifically methylates the adenine in position 2030 of 23S rRNA
b3500	316407.85676544	1.1e-264	918.7	Escherichia	gor	GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918		R00094,R00115	RC00011	ko00000,ko00001,ko01000			iZ_1308.Z4900	Escherichia	1MU2Z@1224,1RMC0@1236,3XNV7@561,COG1249@1,COG1249@2	NA|NA|NA	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
b3501	316407.85676543	2.8e-60	237.7	Escherichia	arsR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0046685,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K03892					ko00000,ko03000				Escherichia	1MZT1@1224,1SAI5@1236,3XPX9@561,COG0640@1,COG0640@2	NA|NA|NA	K	Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity)
b3502	155864.EDL933_4742	4.3e-231	807.0	Escherichia	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008490,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042960,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656		ko:K03893					ko00000,ko02000	2.A.45.1,3.A.4.1		iAF1260.b3502,iB21_1397.B21_03304,iBWG_1329.BWG_3192,iECBD_1354.ECBD_0238,iECB_1328.ECB_03351,iECDH10B_1368.ECDH10B_3678,iECDH1ME8569_1439.ECDH1ME8569_3381,iECD_1391.ECD_03351,iECH74115_1262.ECH74115_4851,iECIAI1_1343.ECIAI1_3649,iECO103_1326.ECO103_4229,iECO111_1330.ECO111_4311,iECO26_1355.ECO26_4590,iECSE_1348.ECSE_3768,iECSP_1301.ECSP_4482,iECs_1301.ECs4374,iETEC_1333.ETEC_3749,iEcDH1_1363.EcDH1_0212,iEcE24377_1341.EcE24377A_3985,iEcHS_1320.EcHS_A3704,iEcolC_1368.EcolC_0214,iG2583_1286.G2583_4228,iJO1366.b3502,iSFV_1184.SFV_3514,iSF_1195.SF3535,iS_1188.S4233,iUMNK88_1353.UMNK88_4279,iY75_1357.Y75_RS19690,iZ_1308.Z4904	Escherichia	1MUX4@1224,1RMAV@1236,3XPC3@561,COG1055@1,COG1055@2	NA|NA|NA	U	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
b3503	198214.SF3536	5.4e-74	283.5	Gammaproteobacteria													Escherichia	1MZ4Z@1224,1S3Z8@1236,COG1393@1,COG1393@2	NA|NA|NA	P	arsenate reductase
b3504	481805.EcolC_0212	3.2e-106	391.3	Gammaproteobacteria													Escherichia	1NS1S@1224,1SKRW@1236,2DU92@1,33PF7@2	NA|NA|NA		
b3505	316407.1736552	5.6e-194	683.3	Gammaproteobacteria													Escherichia	1MVDK@1224,1RR0T@1236,COG3039@1,COG3039@2	NA|NA|NA	L	COG3039 Transposase and inactivated derivatives IS5 family
b3506	316407.85676538	2.9e-107	394.4	Escherichia	slp	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802		ko:K07285					ko00000				Escherichia	1MZ8C@1224,1S9UB@1236,3XPBG@561,COG3065@1,COG3065@2	NA|NA|NA	M	Outer membrane protein slp
b3507	316407.85676537	3.2e-92	344.4	Escherichia	dctR	GO:0006109,GO:0008150,GO:0009894,GO:0010675,GO:0019222,GO:0031323,GO:0031329,GO:0043470,GO:0043471,GO:0050789,GO:0050794,GO:0060255,GO:0065007,GO:0080090		ko:K21901					ko00000,ko03000				Escherichia	1NQRW@1224,1SJSE@1236,3XPP2@561,COG2197@1,COG2197@2	NA|NA|NA	K	May act as a transcriptional regulator of dctA
b3508	316407.85676536	2.9e-111	407.9	Escherichia	yhiD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07507					ko00000,ko02000	9.B.20			Escherichia	1MURJ@1224,1RPR1@1236,3XQPA@561,COG1285@1,COG1285@2	NA|NA|NA	S	MgtC family
b3509	198214.SF3543	2.1e-54	218.0	Gammaproteobacteria													Escherichia	1N783@1224,1SD8J@1236,2EACP@1,334GK@2	NA|NA|NA	M	Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins
b3510	155864.EDL933_4760	9.8e-55	219.2	Escherichia	hdeA	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0042802,GO:0050896,GO:0051087,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0104004		ko:K19777					ko00000,ko03110				Escherichia	1NBBC@1224,1SH1A@1236,2E34D@1,32Y4G@2,3XQZE@561	NA|NA|NA	M	Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non- specifically the aggregation of denaturated periplasmic proteins
b3511	155864.EDL933_4761	6.4e-94	350.1	Escherichia	hdeD	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009268,GO:0009628,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K21908					ko00000	9.B.36.1.1			Escherichia	1RFV7@1224,1S4XK@1236,3XMX7@561,COG3247@1,COG3247@2	NA|NA|NA	S	response to pH
b3512	155864.EDL933_4762	2.1e-91	341.7	Escherichia	gadE	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K21907					ko00000,ko03000				Escherichia	1NS5V@1224,1SM5P@1236,3XQTN@561,COG2771@1,COG2771@2	NA|NA|NA	K	Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci
b3513	316407.85676531	5.6e-206	723.4	Escherichia	mdtE	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0006869,GO:0008150,GO:0010876,GO:0015238,GO:0015711,GO:0015718,GO:0015721,GO:0015849,GO:0015850,GO:0015893,GO:0016020,GO:0022857,GO:0031224,GO:0031226,GO:0033036,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K18898		M00697			ko00000,ko00002,ko01504,ko02000	2.A.6.2,8.A.1.6.3			Escherichia	1MU78@1224,1SJRC@1236,3XPI0@561,COG0845@1,COG0845@2	NA|NA|NA	M	Part of the tripartite efflux system MdtEF-TolC, which confers resistance to
b3514	316407.85676530	0.0	1942.9	Escherichia	mdtF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015893,GO:0016020,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K18899		M00697			ko00000,ko00002,ko01504,ko02000	2.A.6.2.13			Escherichia	1MU48@1224,1SK4F@1236,3XMW6@561,COG0841@1,COG0841@2	NA|NA|NA	V	Part of the tripartite efflux system MdtEF-TolC, which confers resistance to
b3515	155864.EDL933_4766	6.1e-134	483.4	Escherichia	gadW	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K21906					ko00000,ko03000				Escherichia	1QIIZ@1224,1TGDT@1236,3XQQ1@561,COG2207@1,COG2207@2	NA|NA|NA	K	Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters
b3516	316407.85676528	2.4e-150	538.1	Escherichia	gadX	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K21905					ko00000,ko03000				Escherichia	1QIG0@1224,1TGAB@1236,3XQ8H@561,COG2207@1,COG2207@2	NA|NA|NA	K	Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA, gadB and gadC. Depending on the conditions (growth phase and medium), can repress gadW
b3517	199310.c4328	1.1e-285	988.4	Escherichia	gadA	GO:0003674,GO:0003824,GO:0004351,GO:0006873,GO:0006885,GO:0008150,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019725,GO:0030003,GO:0030004,GO:0030641,GO:0042592,GO:0045852,GO:0048878,GO:0050801,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000			iAF1260.b3517,iE2348C_1286.E2348C_3759,iECDH1ME8569_1439.ECDH1ME8569_3396,iECUMN_1333.ECUMN_1747,iEcDH1_1363.EcDH1_0196,iEcolC_1368.EcolC_0200,iJO1366.b3517,iJR904.b3517	Escherichia	1MX25@1224,1RNSQ@1236,3XMMA@561,COG0076@1,COG0076@2	NA|NA|NA	E	Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria
b3518	316407.85676526	5.1e-278	963.0	Escherichia	yhjA	GO:0000302,GO:0003674,GO:0003824,GO:0004130,GO:0004601,GO:0005488,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009061,GO:0009636,GO:0009987,GO:0010035,GO:0015980,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017144,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0042221,GO:0042493,GO:0042542,GO:0042743,GO:0044237,GO:0045333,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051716,GO:0055114,GO:0070887,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1990748	1.11.1.5	ko:K00428					ko00000,ko01000				Escherichia	1MV70@1224,1RPPQ@1236,3XNH5@561,COG1858@1,COG1858@2	NA|NA|NA	C	cytochrome C peroxidase
b3519	155864.EDL933_4772	0.0	1135.9	Escherichia	treF	GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009628,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0033554,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0050896,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071704,GO:0104004,GO:1901575	3.2.1.28	ko:K01194	ko00500,ko01100,map00500,map01100		R00010	RC00049	ko00000,ko00001,ko00537,ko01000		GH37	iSBO_1134.SBO_3518	Escherichia	1MWSM@1224,1RMFP@1236,3XMAI@561,COG1626@1,COG1626@2	NA|NA|NA	G	Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity
b3520	316407.85676524	1.8e-107	395.2	Escherichia	yhjB	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1NRJH@1224,1S15H@1236,3XNTW@561,COG2197@1,COG2197@2	NA|NA|NA	K	nucleic acid-templated transcription
b3521	316407.85676523	1e-167	595.9	Escherichia	yhjC	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Escherichia	1MV06@1224,1RPI0@1236,3XNXD@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator
b3522	316407.85676522	1.4e-184	652.1	Escherichia	yhjD	GO:0003674,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015920,GO:0016020,GO:0016021,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0033036,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1901264,GO:1901505		ko:K07058					ko00000				Escherichia	1N04V@1224,1RNIB@1236,3XMFQ@561,COG1295@1,COG1295@2	NA|NA|NA	S	lipopolysaccharide transmembrane transporter activity
b3523	316407.85676521	3.7e-238	830.5	Escherichia	yhjE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MU46@1224,1RMF0@1236,3XM70@561,COG0477@1,COG0477@2	NA|NA|NA	P	transmembrane transporter activity
b3524	316407.85676520	0.0	1352.0	Escherichia	yhjG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475		ko:K07290					ko00000	9.B.121			Escherichia	1MUAN@1224,1RNZM@1236,3XN25@561,COG2982@1,COG2982@2	NA|NA|NA	M	regulation of protein targeting
b3525	316407.85676519	2.8e-145	521.2	Escherichia	yhjH	GO:0003674,GO:0003824,GO:0008081,GO:0008150,GO:0016787,GO:0016788,GO:0032879,GO:0040012,GO:0042578,GO:0050789,GO:0050794,GO:0051270,GO:0065007,GO:0071111,GO:1902021,GO:2000145	3.1.4.52	ko:K21086	ko02026,map02026				ko00000,ko00001,ko01000				Escherichia	1N1RI@1224,1RQ03@1236,3XMQ2@561,COG2200@1,COG2200@2	NA|NA|NA	T	A bis-(3'-5') cyclic diguanylic acid (c-di-GMP) phosphodiesterase involved in regulating the levels of c-di-GMP that control cell motility (the flagella) and adhesion (adhesive curli fimbriae). The YhjH effect on flagella is controlled via the c-di-GMP-binding flagellar brake protein YcgR, however curli expression is not regulated via YcgR. Forms a network with different diguanylate cyclases (DosC, YeaJ, YedQ, YegE have been identified) to regulate c-di-GMP levels. Flagellar activity is high at low c-di-GMP levels whereas curli fimbria are induced at high c-di-GMP levels. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
b3526	316407.85676518	1.3e-173	615.5	Escherichia	kdgK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008673,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0033554,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0046835,GO:0050896,GO:0051716,GO:0071704,GO:0072329,GO:1901575	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2922,iUTI89_1310.UTI89_C4058	Escherichia	1MVG2@1224,1RNH5@1236,3XMJV@561,COG0524@1,COG0524@2	NA|NA|NA	G	2-dehydro-3-deoxygluconokinase activity
b3527	316407.85676517	7.1e-286	989.2	Escherichia	yhjJ												Escherichia	1NAH6@1224,1RNKC@1236,3XN4Q@561,COG0612@1,COG0612@2	NA|NA|NA	S	metallopeptidase activity
b3528	199310.c4340	1.2e-225	788.9	Escherichia	dctA	GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0006950,GO:0006974,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015138,GO:0015140,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015366,GO:0015556,GO:0015672,GO:0015711,GO:0015740,GO:0015741,GO:0015743,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0033554,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070778,GO:0071422,GO:0071423,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902475,GO:1902600,GO:1903825,GO:1905039		ko:K11103	ko02020,map02020				ko00000,ko00001,ko02000	2.A.23.1.3,2.A.23.1.6,2.A.23.1.7		iSDY_1059.SDY_4548	Escherichia	1MU0Q@1224,1RMEN@1236,3XNK8@561,COG1301@1,COG1301@2	NA|NA|NA	C	Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane
b3529	481805.EcolC_0188	0.0	1260.4	Escherichia	yhjK	GO:0003674,GO:0003824,GO:0004112,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0052652,GO:0052653,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576											Escherichia	1RGCV@1224,1S1IZ@1236,3XNZ7@561,COG2199@1,COG2199@2,COG2200@1,COG2200@2	NA|NA|NA	T	3',5'-cyclic diguanylic acid metabolic process
b3530	316407.85676514	0.0	2179.4	Escherichia	bcsC			ko:K20543					ko00000,ko02000	1.B.55.3			Escherichia	1MVB8@1224,1RPSN@1236,3XMYE@561,COG0457@1,COG0457@2,COG3118@1,COG3118@2	NA|NA|NA	O	cellulose synthase operon protein C
b3531	316407.85676513	2.9e-220	770.8	Escherichia	bcsZ	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0008810,GO:0016787,GO:0016798	3.2.1.4	ko:K20542					ko00000,ko01000		GH8		Escherichia	1MW17@1224,1RNEU@1236,3XP70@561,COG3405@1,COG3405@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family
b3532	316407.85676512	0.0	1558.9	Escherichia	bcsB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K20541					ko00000,ko02000	4.D.3.1.6			Escherichia	1MWF8@1224,1RPJ6@1236,3XNAD@561,COG1215@1,COG1215@2	NA|NA|NA	M	Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP)
b3533	316407.85676511	0.0	1783.1	Escherichia	bcsA	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016020,GO:0016051,GO:0030243,GO:0030244,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:0071944,GO:0090540,GO:1901576	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026		R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2		Escherichia	1MWF8@1224,1RPJ6@1236,3XM9Y@561,COG1215@1,COG1215@2	NA|NA|NA	M	Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae
b3534	198214.SF3565	1e-139	502.7	Gammaproteobacteria													Escherichia	1MXFI@1224,1RYAG@1236,COG1192@1,COG1192@2	NA|NA|NA	D	Cellulose synthase
b3535	316407.85676510	2.2e-27	127.5	Escherichia	yhjR	GO:0000271,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0030243,GO:0030244,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0051273,GO:0051274,GO:0071704,GO:0090540,GO:1901576											Escherichia	1NKIS@1224,1SHIW@1236,2DRDK@1,33BAX@2,3XQ50@561	NA|NA|NA	S	bacterial cellulose biosynthetic process
b3536	316407.85676509	5.7e-310	1069.3	Escherichia	bcsE	GO:0000166,GO:0003674,GO:0005488,GO:0008144,GO:0017076,GO:0019001,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0035438,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363											Escherichia	1R485@1224,1RQGD@1236,28JMX@1,2Z9EC@2,3XNE5@561	NA|NA|NA	S	cyclic-di-GMP binding
b3537	155864.EDL933_4793	3.5e-25	120.2	Escherichia	bcsF												Escherichia	1N7UP@1224,1SDDF@1236,2E541@1,32ZX1@2,3XQ2X@561	NA|NA|NA	S	Cellulose biosynthesis protein BcsF
b3538	316407.85676507	0.0	1099.3	Escherichia	bcsG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MWJY@1224,1RN4T@1236,3XNT8@561,COG2194@1,COG2194@2	NA|NA|NA	S	cellulose biosynthetic process
b4453	198214.SF3573	7.3e-12	75.1	Gammaproteobacteria													Escherichia	1NH19@1224,1SHTV@1236,2DRFU@1,33BJB@2	NA|NA|NA	S	Toxin Ldr, type I toxin-antitoxin system
b3539	316407.85676505	2.2e-227	794.7	Escherichia	yhjV	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0016020,GO:0044464,GO:0050896,GO:0071944											Escherichia	1PCGR@1224,1RSH4@1236,3XN9W@561,COG0814@1,COG0814@2	NA|NA|NA	E	amino acid transmembrane transport
b3540	316407.85676504	2.9e-190	671.0	Escherichia	dppF	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0009314,GO:0009628,GO:0015232,GO:0015886,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678		ko:K12372	ko02010,map02010	M00324			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iSF_1195.SF3575,iSFxv_1172.SFxv_3897,iS_1188.S4195	Escherichia	1NU4K@1224,1SKPD@1236,3XMBJ@561,COG4608@1,COG4608@2	NA|NA|NA	P	Belongs to the ABC transporter superfamily
b3541	155864.EDL933_4799	1.9e-183	648.3	Escherichia	dppD	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015232,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678		ko:K12371	ko02010,map02010	M00324			ko00000,ko00001,ko00002,ko02000	3.A.1.5			Escherichia	1R4KB@1224,1SMBI@1236,3XM53@561,COG0444@1,COG0444@2	NA|NA|NA	EP	Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system
b3542	155864.EDL933_4800	8.4e-133	479.9	Escherichia	dppC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K12370	ko02010,map02010	M00324			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iAF1260.b3542,iAPECO1_1312.APECO1_2906,iB21_1397.B21_03344,iBWG_1329.BWG_3231,iE2348C_1286.E2348C_3790,iEC042_1314.EC042_3848,iEC55989_1330.EC55989_3993,iECABU_c1320.ECABU_c39840,iECBD_1354.ECBD_0194,iECB_1328.ECB_03393,iECDH10B_1368.ECDH10B_3721,iECDH1ME8569_1439.ECDH1ME8569_3422,iECD_1391.ECD_03393,iECED1_1282.ECED1_4221,iECH74115_1262.ECH74115_4910,iECIAI1_1343.ECIAI1_3700,iECIAI39_1322.ECIAI39_4051,iECNA114_1301.ECNA114_3693,iECO103_1326.ECO103_4274,iECO111_1330.ECO111_4358,iECO26_1355.ECO26_4636,iECOK1_1307.ECOK1_3988,iECP_1309.ECP_3643,iECS88_1305.ECS88_3962,iECSE_1348.ECSE_3815,iECSF_1327.ECSF_3376,iECSP_1301.ECSP_4533,iECUMN_1333.ECUMN_4052,iECW_1372.ECW_m3808,iECs_1301.ECs4422,iEKO11_1354.EKO11_0191,iETEC_1333.ETEC_3787,iEcDH1_1363.EcDH1_0170,iEcE24377_1341.EcE24377A_4034,iEcHS_1320.EcHS_A3741,iEcSMS35_1347.EcSMS35_3861,iEcolC_1368.EcolC_0173,iG2583_1286.G2583_4279,iJO1366.b3542,iLF82_1304.LF82_0517,iNRG857_1313.NRG857_17605,iUMN146_1321.UM146_17880,iUMNK88_1353.UMNK88_4323,iUTI89_1310.UTI89_C4080,iWFL_1372.ECW_m3808,iY75_1357.Y75_RS19465,iZ_1308.Z4959,ic_1306.c4357	Escherichia	1MUG0@1224,1RN08@1236,3XM6Q@561,COG1173@1,COG1173@2	NA|NA|NA	EP	probably responsible for the translocation of the substrate across the membrane
b3543	199310.c4358	3.9e-187	660.6	Escherichia	dppB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K12369	ko02010,map02010	M00324			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iECUMN_1333.ECUMN_4053	Escherichia	1MU8Z@1224,1RNJ1@1236,3XMU4@561,COG0601@1,COG0601@2	NA|NA|NA	EP	probably responsible for the translocation of the substrate across the membrane
b3544	316407.85676500	0.0	1096.6	Escherichia	dppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0008150,GO:0009987,GO:0015833,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:0097159,GO:1901363		ko:K12368	ko02010,ko02030,map02010,map02030	M00324			ko00000,ko00001,ko00002,ko02000	3.A.1.5		iSSON_1240.SSON_3846	Escherichia	1MUZH@1224,1RNES@1236,3XMYT@561,COG0747@1,COG0747@2	NA|NA|NA	E	Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis
b3546	316407.85676499	0.0	1134.0	Escherichia	eptB	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043838,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.7.8.42	ko:K12975	ko00540,ko01503,map00540,map01503	M00723	R11204,R11205	RC00017,RC00428	ko00000,ko00001,ko00002,ko01000,ko01005			iSSON_1240.SSON_3844	Escherichia	1MWS7@1224,1RMNG@1236,3XPCS@561,COG2194@1,COG2194@2	NA|NA|NA	S	Catalyzes the addition of a phosphoethanolamine (pEtN) moiety to the outer 3-deoxy-D-manno-octulosonic acid (Kdo) residue of a Kdo(2)-lipid A. Phosphatidylethanolamines with one unsaturated acyl group functions as pEtN donors and the reaction releases diacylglycerol
b3547	316407.85676498	3.1e-191	674.5	Escherichia	yhjX	GO:0005575,GO:0005623,GO:0005886,GO:0007154,GO:0008150,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0031667,GO:0031668,GO:0031669,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944		ko:K08177					ko00000,ko02000	2.A.1.11			Escherichia	1MWC7@1224,1RY1W@1236,3XP8V@561,COG2223@1,COG2223@2	NA|NA|NA	P	Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS BtsR and YpdA YpdB, and their respective target proteins, YjiY and YhjX
b3548	316407.85676497	6.1e-131	473.4	Escherichia	yhjY												Escherichia	1N2A9@1224,1RSZ5@1236,3XM2N@561,COG5571@1,COG5571@2	NA|NA|NA	N	Autotransporter beta-domain
b3549	316407.85676496	5.8e-108	396.7	Escherichia	tag		3.2.2.20	ko:K01246	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Escherichia	1R9X5@1224,1S25K@1236,3XNN4@561,COG2818@1,COG2818@2	NA|NA|NA	L	glycosylase I
b3550	316407.85676495	3.9e-83	313.9	Escherichia	yiaC			ko:K03826					ko00000,ko01000				Escherichia	1MZQ5@1224,1S45R@1236,3XPJZ@561,COG0454@1,COG0456@2	NA|NA|NA	K	transferase activity, transferring acyl groups
b3551	511145.b3551	0.0	1620.9	Escherichia	bisC	GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0030151,GO:0033744,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114		ko:K08351	ko00780,ko01100,map00780,map01100		R10127	RC03056	ko00000,ko00001,ko01000,ko02000	5.A.3.4		iECOK1_1307.ECOK1_3996,iEcHS_1320.EcHS_A3752,iEcolC_1368.EcolC_0165,iUTI89_1310.UTI89_C4091	Escherichia	1NR6J@1224,1RMVE@1236,3XNDI@561,COG0243@1,COG0243@2	NA|NA|NA	C	This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin. Also exhibits methionine-(S)-sulfoxide (Met-S-SO) reductase activity, acting specifically on the (S) enantiomer in the free, but not the protein-bound form. It thus plays a role in assimilation of oxidized methionines
b3552	1440052.EAKF1_ch2389c	1.4e-89	335.9	Escherichia	yiaD												Escherichia	1MYBP@1224,1RVRF@1236,3XNTG@561,COG2885@1,COG2885@2	NA|NA|NA	M	Belongs to the ompA family
b3553	316407.85676492	4e-181	640.6	Escherichia	ghrB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008873,GO:0008875,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0019520,GO:0019522,GO:0019752,GO:0030267,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046176,GO:0046181,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.215,1.1.1.79,1.1.1.81	ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120		R00465,R01388,R01392,R01739	RC00031,RC00042,RC00084	ko00000,ko00001,ko01000			iSFV_1184.SFV_3534	Escherichia	1MU2D@1224,1RMGZ@1236,3XNIJ@561,COG1052@1,COG1052@2	NA|NA|NA	CH	Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively
b3554	155864.EDL933_4819	1.4e-127	462.2	Escherichia	yiaF	GO:0008150,GO:0009987,GO:0044764,GO:0051704											Escherichia	1QD1H@1224,1RNW1@1236,28M2J@1,2ZAGZ@2,3XMJB@561	NA|NA|NA	S	multi-organism cellular process
b3555	155864.EDL933_4820	1e-44	185.7	Escherichia	yiaG			ko:K07726					ko00000,ko03000				Escherichia	1MZTT@1224,1S95K@1236,3XPXQ@561,COG2944@1,COG2944@2	NA|NA|NA	K	HTH-type transcriptional regulator YiaG
b3556	1028307.EAE_06080	6.7e-33	146.0	Enterobacter													Escherichia	1N6Q5@1224,1SCA7@1236,3X2PC@547,COG1278@1,COG1278@2	NA|NA|NA	K	SMART Cold shock protein
b4455	316407.85676488	7.9e-20	102.1	Proteobacteria													Escherichia	1NF35@1224,2EFY7@1,337V7@2	NA|NA|NA	S	PFAM Hok gef
b3557	316407.85676487	2.1e-91	341.7	Gammaproteobacteria													Escherichia	1R68G@1224,1RPUA@1236,COG2963@1,COG2963@2	NA|NA|NA	L	sequence-specific DNA binding
b3558	469008.B21_00609	1.5e-160	572.0	Gammaproteobacteria													Escherichia	1PNRG@1224,1RPA5@1236,COG2801@1,COG2801@2	NA|NA|NA	L	COG2801 Transposase and inactivated derivatives
b3559	316407.85676485	0.0	1300.0	Escherichia	glyS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378	Escherichia	1MV2F@1224,1RNR3@1236,3XNJZ@561,COG0751@1,COG0751@2	NA|NA|NA	J	Glycyl-tRNA synthetase beta subunit
b3560	316407.85676484	2.7e-179	634.4	Escherichia	glyQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF1260.b3560,iJO1366.b3560,iY75_1357.Y75_RS19360	Escherichia	1MVCJ@1224,1RMYI@1236,3XP5A@561,COG0752@1,COG0752@2	NA|NA|NA	J	glycyl-tRNA synthetase alpha subunit
b4553	316407.85676483	3.2e-49	200.7	Escherichia	ysaB												Escherichia	1N2GI@1224,1SAV9@1236,2CYUU@1,32T4W@2,3XPWG@561	NA|NA|NA	S	YsaB-like lipoprotein
b3561	316407.85676482	1.5e-186	658.7	Escherichia	wecH	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008374,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016020,GO:0016051,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046378,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576											Escherichia	1PX98@1224,1RMGG@1236,3XN6K@561,COG3274@1,COG3274@2	NA|NA|NA	S	Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units
b3562	155864.EDL933_4827	3.3e-74	284.3	Escherichia	yiaA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033554,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071944											Escherichia	1RH8F@1224,1S6WM@1236,3XQIU@561,COG4682@1,COG4682@2	NA|NA|NA	S	cellular response to DNA damage stimulus
b3563	316407.85676480	1.6e-55	221.9	Escherichia	yiaB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033554,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071944											Escherichia	1NZD0@1224,1SQS9@1236,3XPXN@561,COG4682@1,COG4682@2	NA|NA|NA	S	cellular response to DNA damage stimulus
b3564	316407.85676479	1.5e-280	971.5	Escherichia	xylB	GO:0003674,GO:0003824,GO:0004856,GO:0005975,GO:0005996,GO:0005997,GO:0005998,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2885,iEC55989_1330.EC55989_4019,iECIAI1_1343.ECIAI1_3729,iECO103_1326.ECO103_4670,iECO111_1330.ECO111_4384,iECO26_1355.ECO26_5037,iECOK1_1307.ECOK1_4011,iECP_1309.ECP_3667,iECS88_1305.ECS88_3982,iECSE_1348.ECSE_3838,iECW_1372.ECW_m3838,iEKO11_1354.EKO11_0162,iUMN146_1321.UM146_17990,iUTI89_1310.UTI89_C4105,iWFL_1372.ECW_m3838	Escherichia	1MW4A@1224,1RR7X@1236,3XNNY@561,COG1070@1,COG1070@2	NA|NA|NA	F	xylulose metabolic process
b3565	316407.85676478	1.4e-264	918.3	Escherichia	xylA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100		R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000			iECO26_1355.ECO26_5036	Escherichia	1MXS2@1224,1RN5Y@1236,3XMQW@561,COG2115@1,COG2115@2	NA|NA|NA	G	Belongs to the xylose isomerase family
b3566	316407.85676477	1.7e-179	635.2	Escherichia	xylF	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704		ko:K10543	ko02010,map02010	M00215			ko00000,ko00001,ko00002,ko02000	3.A.1.2.4		iB21_1397.B21_03369,iECBD_1354.ECBD_0168,iECD_1391.ECD_03418,iEcHS_1320.EcHS_A3769,iEcolC_1368.EcolC_0148,iUTI89_1310.UTI89_C4107,ic_1306.c4386	Escherichia	1MX63@1224,1RRJ3@1236,3XM8D@561,COG4213@1,COG4213@2	NA|NA|NA	G	D-xylose metabolic process
b3567	316407.85676476	1.2e-291	1008.4	Escherichia	xylG	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0006810,GO:0008144,GO:0008150,GO:0008152,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015148,GO:0015749,GO:0015750,GO:0015753,GO:0017076,GO:0019321,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034219,GO:0035639,GO:0036094,GO:0042732,GO:0043167,GO:0043168,GO:0044238,GO:0044281,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.17	ko:K10545	ko02010,map02010	M00215			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4		iECABU_c1320.ECABU_c40100,iECP_1309.ECP_3670,iSF_1195.SF3611,iS_1188.S4158	Escherichia	1MU22@1224,1RMCH@1236,3XPAB@561,COG1129@1,COG1129@2	NA|NA|NA	G	Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system
b3568	155864.EDL933_4833	8.3e-197	693.0	Escherichia	xylH	GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0019321,GO:0031224,GO:0042732,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0071704,GO:0071944		ko:K10544	ko02010,map02010	M00215			ko00000,ko00001,ko00002,ko02000	3.A.1.2.4		iEC55989_1330.EC55989_4023	Escherichia	1MXXS@1224,1RNWF@1236,3XP4K@561,COG4214@1,COG4214@2	NA|NA|NA	G	Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane
b3569	155864.EDL933_4834	1.2e-224	785.4	Escherichia	xylR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141		ko:K02529					ko00000,ko03000				Escherichia	1NYTD@1224,1RNGZ@1236,3XN8D@561,COG1609@1,COG1609@2,COG2207@1,COG2207@2	NA|NA|NA	K	Regulatory protein for the xylBAFGHR operon
b3570	199310.c4390	1e-132	479.6	Escherichia	bax			ko:K03796					ko00000		GH73		Escherichia	1RD3U@1224,1S3RA@1236,3XN6F@561,COG2992@1,COG2992@2	NA|NA|NA	S	amidase activity
b3571	316407.85676472	0.0	1426.8	Escherichia	malS	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0016052,GO:0016160,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0030978,GO:0030980,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044464,GO:0046872,GO:0051691,GO:0051692,GO:0071704,GO:1901575	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973		R02108,R02112,R11262		ko00000,ko00001,ko01000		GH13	iECABU_c1320.ECABU_c40140,iECP_1309.ECP_3675,iECSE_1348.ECSE_3847,ic_1306.c4392	Escherichia	1MU90@1224,1RQ1S@1236,3XN2F@561,COG0366@1,COG0366@2	NA|NA|NA	G	Since only maltooligosaccharides up to a chain length of 6 glucose units are actively transported through the cytoplasmic membrane via the membrane-bound complex of three proteins, MalF, MalG, and MalK, longer maltooligosaccharides must first be degraded by the periplasmic alpha-amylase, the MalS protein
b3572	316407.85676471	3.1e-250	870.5	Escherichia	avtA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009042,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0030632,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.66	ko:K00835	ko00290,ko01100,ko01110,ko01130,map00290,map01100,map01110,map01130		R01215	RC00008,RC00036	ko00000,ko00001,ko01000,ko01007			iEKO11_1354.EKO11_0154,iEcSMS35_1347.EcSMS35_3895	Escherichia	1MVRW@1224,1RNK1@1236,3XNPA@561,COG3977@1,COG3977@2	NA|NA|NA	E	Valine--pyruvate aminotransferase
b3573	316407.85676470	8.4e-92	342.8	Escherichia	ysaA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114											Escherichia	1PENN@1224,1RS57@1236,3XRFG@561,COG1142@1,COG1142@2	NA|NA|NA	C	4 iron, 4 sulfur cluster binding
b3574	316407.85676469	1.2e-157	562.4	Escherichia	yiaJ	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K21602					ko00000,ko03000				Escherichia	1MUNW@1224,1RRE5@1236,3XMNS@561,COG1414@1,COG1414@2	NA|NA|NA	K	transcriptional
b3575	316407.85676468	4.9e-190	670.2	Escherichia	yiaK	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114	1.1.1.130	ko:K08092	ko00040,ko00053,map00040,map00053		R02637,R02639	RC00238	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_4032,iECIAI1_1343.ECIAI1_3742,iECO103_1326.ECO103_4659,iECO111_1330.ECO111_4395,iECO26_1355.ECO26_5026,iECSE_1348.ECSE_3851,iECW_1372.ECW_m3849,iEKO11_1354.EKO11_0151,iSF_1195.SF3619,iSFxv_1172.SFxv_3943,iS_1188.S4150,iWFL_1372.ECW_m3849	Escherichia	1MWQY@1224,1RSGK@1236,3XMM4@561,COG2055@1,COG2055@2	NA|NA|NA	C	Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate
b3576	316407.85676467	6.4e-84	316.6	Escherichia	yiaL	GO:0008150,GO:0009314,GO:0009628,GO:0050896											Escherichia	1N8IZ@1224,1T0V3@1236,3XP74@561,COG2731@1,COG2731@2	NA|NA|NA	G	response to radiation
b3577	316407.85676466	2.5e-80	304.7	Gammaproteobacteria													Escherichia	1NBJ4@1224,1SAXN@1236,COG3090@1,COG3090@2	NA|NA|NA	G	TRAP transporter small permease
b3578	316407.85676465	5.6e-223	780.0	Escherichia	yiaN	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0016020,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K21393					ko00000,ko02000	2.A.56.1		iECABU_c1320.ECABU_c40220,iECNA114_1301.ECNA114_3731,iECO103_1326.ECO103_4656,iECOK1_1307.ECOK1_4026,iECP_1309.ECP_3683,iECSF_1327.ECSF_3414,iLF82_1304.LF82_3342,iNRG857_1313.NRG857_17820,iUMN146_1321.UM146_18065,iUTI89_1310.UTI89_C4121,ic_1306.c4400	Escherichia	1MU0F@1224,1RRZ7@1236,3XN0Q@561,COG1593@1,COG1593@2	NA|NA|NA	P	2,3-diketo-L-gulonate TRAP transporter large permease protein YiaN
b3579	316407.85676464	3.7e-182	644.0	Escherichia	yiaO	GO:0003674,GO:0005488,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009987,GO:0030246,GO:0033554,GO:0034219,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702		ko:K21395					ko00000,ko02000	2.A.56.1		iECSE_1348.ECSE_3855,iEcE24377_1341.EcE24377A_4076,iUMNK88_1353.UMNK88_4364	Escherichia	1MVHC@1224,1RUFU@1236,3XN4F@561,COG1638@1,COG1638@2	NA|NA|NA	G	Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3- diketo-L-gulonate. This protein specifically binds 2,3-diketo-L- gulonate. Is not able to bind either L-ascorbate or dehydroascorbate
b3580	316407.85676463	2.7e-301	1040.4	Escherichia	lyxK	GO:0003674,GO:0003824,GO:0004856,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008744,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019324,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704	2.7.1.53	ko:K00880	ko00040,ko00053,map00040,map00053		R01901,R07127	RC00002,RC00017,RC00538	ko00000,ko00001,ko01000			iEcSMS35_1347.EcSMS35_3903	Escherichia	1MWS5@1224,1RP2G@1236,3XP88@561,COG1070@1,COG1070@2	NA|NA|NA	G	Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate
b3581	316407.85676462	1.9e-121	441.8	Escherichia	sgbH	GO:0003674,GO:0003824,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016831,GO:0033982,GO:0044238,GO:0071704,GO:1901575	4.1.1.85	ko:K03078	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R07125	RC01721	ko00000,ko00001,ko00002,ko01000			iLF82_1304.LF82_2128,iNRG857_1313.NRG857_17835	Escherichia	1QWE4@1224,1RRCI@1236,3XMQG@561,COG0269@1,COG0269@2	NA|NA|NA	G	Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2,3- diketo-L-gulonate
b3582	316407.85676461	1.4e-164	585.5	Escherichia	sgbU	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019324,GO:0034015,GO:0044238,GO:0044281,GO:0071704	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000				Escherichia	1MWTD@1224,1RPT6@1236,3XM8E@561,COG3623@1,COG3623@2	NA|NA|NA	G	Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate (Potential). May be involved in the utilization of 2,3-diketo-L-gulonate
b3583	316407.85676460	4.2e-132	477.2	Escherichia	sgbE	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008270,GO:0008742,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019324,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046872,GO:0046914,GO:0071704,GO:1901575	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000			iECO111_1330.ECO111_4403,iLF82_1304.LF82_2127,iNRG857_1313.NRG857_17845	Escherichia	1MU54@1224,1RMIP@1236,3XQC1@561,COG0235@1,COG0235@2	NA|NA|NA	G	L-ribulose-5-phosphate 4-epimerase
b3584	316407.85676459	4.2e-138	497.3	Escherichia	yiaT	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944		ko:K07274					ko00000,ko02000	9.B.99.1			Escherichia	1MWQN@1224,1RQTM@1236,3XM2G@561,COG3713@1,COG3713@2	NA|NA|NA	M	May serve as a scaffold protein required for the formation of a complex with MrcB PonB and MltA, this complex could play a role in enlargement and septation of the murein sacculus
b3585	316407.85676458	3.9e-184	650.6	Gammaproteobacteria													Escherichia	1R72C@1224,1RRH2@1236,COG0583@1,COG0583@2	NA|NA|NA	K	Transcriptional regulator
b3586	316407.85676457	1e-204	719.2	Escherichia	yiaV	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1NAMI@1224,1RP4N@1236,3XP6B@561,COG1566@1,COG1566@2	NA|NA|NA	V	membrane
b3587	155864.EDL933_4845	2.3e-53	214.5	Escherichia	yiaW	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1N0NJ@1224,1S9BM@1236,2CIMK@1,32S89@2,3XPRA@561	NA|NA|NA	S	Protein of unknown function (DUF3302)
b3588	316407.85676455	2.1e-301	1040.8	Escherichia	aldB	GO:0003674,GO:0003824,GO:0004029,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016620,GO:0016903,GO:0033554,GO:0042221,GO:0042493,GO:0045471,GO:0046677,GO:0050896,GO:0051716,GO:0055114,GO:0097305,GO:1901700		ko:K00138	ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120		R00711	RC00047	ko00000,ko00001,ko01000			iSF_1195.SF3626,iSFxv_1172.SFxv_3952,iS_1188.S4142	Escherichia	1MU1V@1224,1RMBQ@1236,3XMIY@561,COG1012@1,COG1012@2	NA|NA|NA	C	Belongs to the aldehyde dehydrogenase family
b3589	316407.85676454	1.2e-211	742.3	Escherichia	yiaY	GO:0003674,GO:0003824,GO:0004022,GO:0008150,GO:0008152,GO:0008743,GO:0016491,GO:0016614,GO:0016616,GO:0055114	1.1.1.1	ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220		R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000			iSF_1195.SF3627,iS_1188.S4141	Escherichia	1MVPH@1224,1RMVU@1236,3XP0A@561,COG1454@1,COG1454@2	NA|NA|NA	C	L-threonine 3-dehydrogenase activity
b3590	316407.85676453	0.0	1238.0	Escherichia	selB	GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112		ko:K03833					ko00000,ko03012				Escherichia	1MWXH@1224,1RQJI@1236,3XNXT@561,COG3276@1,COG3276@2	NA|NA|NA	J	Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP
b3591	155864.EDL933_4851	3e-246	857.4	Escherichia	selA	GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970		R08219	RC01246	ko00000,ko00001,ko01000			iECP_1309.ECP_3693,iSbBS512_1146.SbBS512_E4006	Escherichia	1MWXI@1224,1RN73@1236,3XMP2@561,COG1921@1,COG1921@2	NA|NA|NA	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis
b3592	199310.c4413	1.5e-109	402.1	Escherichia	yibF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1RHSK@1224,1RR26@1236,3XM6X@561,COG0625@1,COG0625@2	NA|NA|NA	O	Glutathione S-transferase, C-terminal domain
b3593	316407.85676450	0.0	2343.5	Escherichia	rhsA												Escherichia	1MVV1@1224,1SKYM@1236,3XQSX@561,COG3209@1,COG3209@2	NA|NA|NA	M	Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell
b3594	316407.85676449	2.8e-154	551.2	Escherichia	yibA	GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0033554,GO:0042221,GO:0046677,GO:0050896,GO:0051716											Escherichia	1NB0I@1224,1SV0F@1236,3XR9A@561,COG1413@1,COG1413@2	NA|NA|NA	C	response to radiation
b3595	316407.85676448	2e-137	495.0	Bacteria													Escherichia	COG3209@1,COG3209@2	NA|NA|NA	M	self proteolysis
b3596	316407.85676447	8.5e-81	306.2	Proteobacteria													Escherichia	1P4XC@1224,COG0790@1,COG0790@2	NA|NA|NA	S	COG0790 FOG TPR repeat, SEL1 subfamily
b4650	316407.1651309	1.2e-17	95.5	Escherichia	rhsC												Escherichia	1MVV1@1224,1SKYM@1236,3XQSX@561,COG3209@1,COG3209@2	NA|NA|NA	M	Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell
b4615	469008.B21_04470	1.2e-52	212.2	Gammaproteobacteria													Escherichia	1P665@1224,1SVKG@1236,28RN3@1,2ZE0T@2	NA|NA|NA	S	Immunity protein 57
b3597	155864.EDL933_4857	2.5e-206	724.5	Escherichia	yibH	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944											Escherichia	1NAMI@1224,1RP4N@1236,3XP6B@561,COG1566@1,COG1566@2	NA|NA|NA	V	membrane
b3598	316407.85676445	3.1e-62	244.2	Escherichia	yibI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1N0NJ@1224,1S9BM@1236,2CIMK@1,32S89@2,3XPRA@561	NA|NA|NA	S	Protein of unknown function (DUF3302)
b3599	316407.85676444	0.0	1219.9	Escherichia	mtlA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015791,GO:0015797,GO:0015850,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090565	2.7.1.197	ko:K02798,ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5		iAPECO1_1312.APECO1_2858,iEC042_1314.EC042_3906,iECIAI39_1322.ECIAI39_4114,iECOK1_1307.ECOK1_4040,iECS88_1305.ECS88_4012,iECUMN_1333.ECUMN_4110,iUMN146_1321.UM146_18140,iUTI89_1310.UTI89_C4137	Escherichia	1MUPU@1224,1RNAG@1236,3XME2@561,COG2213@1,COG2213@2,COG4668@1,COG4668@2	NA|NA|NA	G	PTS system mannitol-specific
b3600	316407.85676443	8.8e-212	742.7	Escherichia	mtlD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006059,GO:0006066,GO:0008150,GO:0008152,GO:0008926,GO:0009056,GO:0009987,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019400,GO:0019405,GO:0019407,GO:0019592,GO:0019594,GO:0019751,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0055114,GO:0071704,GO:1901575,GO:1901615,GO:1901616	1.1.1.17	ko:K00009	ko00051,map00051		R02703	RC00085	ko00000,ko00001,ko01000			iSBO_1134.SBO_3598,iSbBS512_1146.SbBS512_E4017	Escherichia	1MXV8@1224,1RPCP@1236,3XNQN@561,COG0246@1,COG0246@2	NA|NA|NA	G	mannitol-1-phosphate 5-dehydrogenase activity
b3601	199310.c4418	1.9e-101	375.2	Escherichia	mtlR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K02562					ko00000,ko03000				Escherichia	1NEDY@1224,1RPCM@1236,3XNUX@561,COG3722@1,COG3722@2	NA|NA|NA	K	Involved in the repression of the expression of the mannitol mtlADR operon. Does not bind the operator promoter regulatory region of this operon. Therefore, seems to belong to a new class of transcription factors in bacteria that may regulate gene expression indirectly, perhaps as a part of a larger transcriptional complex
b4554	155864.EDL933_4863	4.3e-32	143.3	Escherichia	yibT	GO:0001101,GO:0008150,GO:0010033,GO:0042221,GO:0050896,GO:0097305,GO:1901422,GO:1901700											Escherichia	1N93Z@1224,1SD4V@1236,2E4DS@1,32Z93@2,3XQ0F@561	NA|NA|NA	S	response to butan-1-ol
b3602	155864.EDL933_4864	6.3e-55	219.9	Escherichia	yibL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K14762					ko00000,ko03009				Escherichia	1RJ19@1224,1S5V8@1236,2AN7V@1,31D5W@2,3XPSG@561	NA|NA|NA	S	Protein of unknown function (DUF2810)
b3603	316407.85676439	5.2e-306	1056.2	Escherichia	lldP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006974,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0033554,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K00427					ko00000,ko02000	2.A.14.1.1		e_coli_core.b3603,iAF1260.b3603,iECDH1ME8569_1439.ECDH1ME8569_3488,iECW_1372.ECW_m3882,iEcDH1_1363.EcDH1_0102,iEcolC_1368.EcolC_0105,iJO1366.b3603,iJR904.b3603,iWFL_1372.ECW_m3882	Escherichia	1MV13@1224,1RPNW@1236,3XNWT@561,COG1620@1,COG1620@2	NA|NA|NA	C	Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force
b3604	198214.SF3643	9.4e-141	506.1	Gammaproteobacteria													Escherichia	1QHAH@1224,1SYG2@1236,COG2186@1,COG2186@2	NA|NA|NA	K	Represses the lctPRD operon
b3605	316407.85676437	2.5e-225	787.7	Escherichia	lldD	GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004459,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006004,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009987,GO:0010181,GO:0015980,GO:0016020,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019317,GO:0019318,GO:0019320,GO:0019516,GO:0019752,GO:0032553,GO:0032787,GO:0036094,GO:0042354,GO:0042355,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044464,GO:0045333,GO:0046365,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575,GO:1901615	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100		R00196	RC00044	ko00000,ko00001,ko01000			iECOK1_1307.ECOK1_4049	Escherichia	1MUEZ@1224,1RPA1@1236,3XP35@561,COG1304@1,COG1304@2	NA|NA|NA	C	Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain
b3606	199310.c4428	4.3e-88	330.5	Escherichia	trmL	GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.207	ko:K03216					ko00000,ko01000,ko03016				Escherichia	1RCY4@1224,1S3PI@1236,3XN4Z@561,COG0219@1,COG0219@2	NA|NA|NA	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
b3607	155864.EDL933_4871	7.4e-152	543.1	Escherichia	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009314,GO:0009333,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000				Escherichia	1MVFX@1224,1RNCA@1236,3XNRD@561,COG1045@1,COG1045@2	NA|NA|NA	E	Belongs to the transferase hexapeptide repeat family
b3608	155864.EDL933_4872	1.2e-188	665.6	Escherichia	gpsA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0055114,GO:0071704,GO:0090407,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110		R00842,R00844	RC00029	ko00000,ko00001,ko01000			iSFV_1184.SFV_3923	Escherichia	1MUU3@1224,1RPQ7@1236,3XNWW@561,COG0240@1,COG0240@2	NA|NA|NA	I	Glycerol-3-phosphate dehydrogenase
b3609	155864.EDL933_4873	6.4e-84	316.6	Escherichia	secB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0043952,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0051082,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0072321		ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5			Escherichia	1RI75@1224,1S62H@1236,3XNNZ@561,COG1952@1,COG1952@2	NA|NA|NA	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
b3610	155864.EDL933_4874	5.5e-42	176.4	Escherichia	grxC	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0033218,GO:0042277,GO:0043167,GO:0043168,GO:0043295,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0055114,GO:0072341,GO:1900750,GO:1901681		ko:K03676					ko00000,ko03110				Escherichia	1N72P@1224,1SCA2@1236,3XPU4@561,COG0695@1,COG0695@2	NA|NA|NA	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
b3611	155864.EDL933_4875	1.4e-72	278.9	Escherichia	yibN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MZ83@1224,1S8ZI@1236,3XNPZ@561,COG0607@1,COG0607@2	NA|NA|NA	P	Rhodanese-like domain
b3612	316407.85676430	5e-295	1019.6	Escherichia	gpmI	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0016853,GO:0016866,GO:0016868,GO:0030145,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046537,GO:0046872,GO:0046914,GO:0050896	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000			iECSE_1348.ECSE_3895	Escherichia	1MUQ1@1224,1RMJE@1236,3XMVW@561,COG0696@1,COG0696@2	NA|NA|NA	F	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
b3613	155864.EDL933_4877	2e-156	558.9	Escherichia	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944											Escherichia	1MY3E@1224,1RPQP@1236,3XMXJ@561,COG4942@1,COG4942@2	NA|NA|NA	D	Activator of the cell wall hydrolases AmiA and AmiB. Required for septal murein cleavage and daughter cell separation during cell division. In vitro, exhibits weak endoproteolytic activity on beta-casein
b3614	316407.85676428	4.1e-178	630.6	Escherichia	yibQ			ko:K09798					ko00000				Escherichia	1N3JP@1224,1RNKH@1236,3XN4X@561,COG2861@1,COG2861@2	NA|NA|NA	S	carbohydrate metabolic process
b3615	316407.85676427	1.4e-200	705.3	Escherichia	yibD	GO:0003674,GO:0003824,GO:0005575,GO:0006950,GO:0007154,GO:0008150,GO:0008194,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015020,GO:0016020,GO:0016036,GO:0016740,GO:0016757,GO:0016758,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496		ko:K19354					ko00000,ko01000,ko01003,ko01005		GT2		Escherichia	1N72Z@1224,1RRQJ@1236,3XMEY@561,COG1216@1,COG1216@2	NA|NA|NA	S	glucuronosyltransferase activity
b3616	316407.85676426	3.1e-200	704.1	Escherichia	tdh	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	1.1.1.103	ko:K00060	ko00260,map00260		R01465	RC00525	ko00000,ko00001,ko01000			iEC042_1314.EC042_3926,iECUMN_1333.ECUMN_4133	Escherichia	1MV9A@1224,1RMNY@1236,3XPEF@561,COG1063@1,COG1063@2	NA|NA|NA	E	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate
b3617	155864.EDL933_4881	2.1e-224	784.6	Escherichia	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0016874,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.3.1.29	ko:K00639	ko00260,map00260		R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007			iECW_1372.ECW_m3896,iEKO11_1354.EKO11_0103,iWFL_1372.ECW_m3896	Escherichia	1MVVH@1224,1RNS6@1236,3XNF2@561,COG0156@1,COG0156@2	NA|NA|NA	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA
b3618	316407.85676424	1.1e-166	592.4	Escherichia	htrL												Escherichia	1R8J9@1224,1RYGV@1236,28KVY@1,2ZACE@2,3XQAX@561	NA|NA|NA	S	Bacterial protein of unknown function (HtrL_YibB)
b3619	155864.EDL933_4883	1.2e-179	635.6	Escherichia	hldD	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008712,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901576,GO:1903509	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005				Escherichia	1MVE4@1224,1RP2S@1236,3XNDJ@561,COG0451@1,COG0451@2	NA|NA|NA	F	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose
b3620	316407.85676422	4.7e-204	716.8	Escherichia	rfaF	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K02843	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT9	iECH74115_1262.ECH74115_4993,iECSP_1301.ECSP_4617,iECs_1301.ECs4498,iG2583_1286.G2583_4359,iZ_1308.Z5047	Escherichia	1MXA2@1224,1RMBF@1236,3XN67@561,COG0859@1,COG0859@2	NA|NA|NA	M	heptosyltransferase II
b3621	316407.85676421	9.4e-183	646.0	Escherichia	rfaC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K02841	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT9	iB21_1397.B21_03429,iECBD_1354.ECBD_0105,iECB_1328.ECB_03478,iECD_1391.ECD_03478,iECNA114_1301.ECNA114_3774,iECSF_1327.ECSF_3456	Escherichia	1MYZA@1224,1RPMN@1236,3XMT5@561,COG0859@1,COG0859@2	NA|NA|NA	M	lipopolysaccharide
b3622	316407.85676420	1.4e-213	748.8	Gammaproteobacteria													Escherichia	1R7C4@1224,1RSH3@1236,COG3307@1,COG3307@2	NA|NA|NA	M	O-antigen ligase
b3623	316407.85676419	1.2e-205	722.2	Escherichia		GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0008610,GO:0008653,GO:0008713,GO:0008917,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K03277	ko00540,ko01100,map00540,map01100				ko00000,ko00001,ko01000,ko01003,ko01005			iAF1260.b3623,iBWG_1329.BWG_3314,iECDH10B_1368.ECDH10B_3805,iECDH1ME8569_1439.ECDH1ME8569_3508,iEcDH1_1363.EcDH1_0082,iJO1366.b3623,iY75_1357.Y75_RS19020	Escherichia	1MYTQ@1224,1SYM4@1236,3XRAE@561,COG0859@1,COG0859@2	NA|NA|NA	M	Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS
b3624	316407.85676418	2.7e-157	561.2	Escherichia		GO:0000271,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K12981	ko00540,map00540				ko00000,ko00001,ko01000,ko01003,ko01005		GT73		Escherichia	1R5PS@1224,1RXZJ@1236,2DB7S@1,2Z7NB@2,3XQVX@561	NA|NA|NA	J	lipopolysaccharide core region biosynthetic process
b3625	316407.85676417	3.5e-126	457.6	Escherichia		GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237		ko:K02850	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01005				Escherichia	1QYXJ@1224,1T3WV@1236,3XRNG@561,COG3642@1,COG3642@2	NA|NA|NA	T	Catalyzes the phosphorylation of heptose(II) of the outer membrane lipopolysaccharide core
b3626	316407.85676416	3.9e-195	687.2	Escherichia	rfaJ	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.58	ko:K03276,ko:K03279	ko00540,ko01100,map00540,map01100	M00080	R01994	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT8	iECP_1309.ECP_3726,iSFV_1184.SFV_3904,iSF_1195.SF3664,iSFxv_1172.SFxv_3993,iS_1188.S4104	Escherichia	1MUEC@1224,1RMCM@1236,3XQE2@561,COG1442@1,COG1442@2	NA|NA|NA	M	Lipopolysaccharide 1,2-glucosyltransferase
b3627	316407.85676415	5.3e-200	703.4	Escherichia	rfaI	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0047270,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K03275	ko00540,ko01100,map00540,map01100				ko00000,ko00001,ko01000,ko01003,ko01005		GT8		Escherichia	1N9H7@1224,1RQGY@1236,3XQM1@561,COG1442@1,COG1442@2	NA|NA|NA	M	lipopolysaccharide glucosyltransferase II activity
b3628	316407.85676414	3.4e-213	747.3	Escherichia		GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035250,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K02840	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT4		Escherichia	1PDRU@1224,1S0YU@1236,3XQF3@561,COG0438@1,COG0438@2	NA|NA|NA	M	Adds a galactose goup to a glucose group of LPS
b3629	316407.85676413	2.2e-176	624.8	Gammaproteobacteria													Escherichia	1MYWC@1224,1T3WU@1236,COG0438@1,COG0438@2	NA|NA|NA	M	transferase activity, transferring glycosyl groups
b3630	316407.85676412	3.5e-151	540.8	Escherichia	rfaP	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237		ko:K02848	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01005			iAF1260.b3630,iBWG_1329.BWG_3321,iEC042_1314.EC042_3937,iECDH10B_1368.ECDH10B_3812,iECDH1ME8569_1439.ECDH1ME8569_3515,iEcDH1_1363.EcDH1_0075,iJO1366.b3630,iY75_1357.Y75_RS18985	Escherichia	1MXX9@1224,1RQFJ@1236,3XMKG@561,COG0515@1,COG0515@2	NA|NA|NA	F	Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core
b3631	316407.85676411	5.2e-217	760.0	Escherichia	rfaG	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K02844	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT4	iSDY_1059.SDY_4061	Escherichia	1NE3V@1224,1RQE3@1236,3XNUU@561,COG0438@1,COG0438@2	NA|NA|NA	M	Lipopolysaccharide core biosynthesis protein RfaG
b3632	316407.85676410	4e-203	713.8	Escherichia	rfaQ	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:0071967,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K02849	ko00540,ko01100,map00540,map01100	M00080			ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT9	iAF1260.b3632,iBWG_1329.BWG_3323,iECDH10B_1368.ECDH10B_3814,iJO1366.b3632,iSSON_1240.SSON_3775,iY75_1357.Y75_RS18975	Escherichia	1MYZA@1224,1RR6K@1236,3XMTY@561,COG0859@1,COG0859@2	NA|NA|NA	M	Catalyzes heptose transfer to the lipopolysaccharide core. It transfers a heptose, called heptose(III), to the heptose(II) of the inner core
b3633	199310.c4457	1e-240	839.0	Escherichia	waaA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005		GT30	iECNA114_1301.ECNA114_3778,iUMNK88_1353.UMNK88_4417	Escherichia	1MU9F@1224,1RNBR@1236,3XNZ6@561,COG1519@1,COG1519@2	NA|NA|NA	M	Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide- 1,4'-bisphosphate precursor of lipid A
b3634	155864.EDL933_4895	8.5e-84	316.2	Escherichia	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_4064	Escherichia	1RD9F@1224,1S41J@1236,3XMRA@561,COG0669@1,COG0669@2	NA|NA|NA	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
b3635	316407.85676407	4.4e-157	560.5	Escherichia	mutM	GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410				ko00000,ko00001,ko01000,ko03400				Escherichia	1MVM5@1224,1RP3J@1236,3XNNS@561,COG0266@1,COG0266@2	NA|NA|NA	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates
b3636	1076550.LH22_02755	3.2e-22	110.2	Pantoea													Escherichia	1N6QV@1224,1SCEJ@1236,3W1AP@53335,COG0267@1,COG0267@2	NA|NA|NA	J	there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc
b3637	198214.SF3676	1.1e-36	158.7	Gammaproteobacteria													Escherichia	1MZ57@1224,1S8UG@1236,COG0227@1,COG0227@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL28 family
b3638	316407.85676404	6.3e-109	400.2	Escherichia	yicR			ko:K03630					ko00000				Escherichia	1MXZ5@1224,1RP86@1236,3XMBP@561,COG2003@1,COG2003@2	NA|NA|NA	E	Belongs to the UPF0758 family. YicR subfamily
b3639	155864.EDL933_4900	2.5e-225	787.7	Escherichia	dfp	GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iSBO_1134.SBO_3641	Escherichia	1MVQP@1224,1RMKQ@1236,3XN0I@561,COG0452@1,COG0452@2	NA|NA|NA	F	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
b3640	316407.85676402	3.8e-81	307.4	Escherichia	dut	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400				Escherichia	1RA7P@1224,1S233@1236,3XND3@561,COG0756@1,COG0756@2	NA|NA|NA	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
b3641	155864.EDL933_4902	1.1e-101	375.9	Escherichia	slmA	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000918,GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0007049,GO:0007346,GO:0008150,GO:0009295,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010564,GO:0010948,GO:0010974,GO:0016043,GO:0019219,GO:0019222,GO:0022402,GO:0022607,GO:0031323,GO:0031326,GO:0031333,GO:0032271,GO:0032272,GO:0032465,GO:0032466,GO:0032506,GO:0032954,GO:0032955,GO:0042802,GO:0043085,GO:0043087,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043547,GO:0043565,GO:0043590,GO:0044085,GO:0044087,GO:0044093,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045786,GO:0045930,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051252,GO:0051301,GO:0051302,GO:0051336,GO:0051345,GO:0051726,GO:0051782,GO:0060255,GO:0061640,GO:0065007,GO:0065009,GO:0071840,GO:0080090,GO:0090529,GO:0097159,GO:0140110,GO:1901363,GO:1901891,GO:1901892,GO:1902410,GO:1902412,GO:1902413,GO:1903047,GO:1903436,GO:1903437,GO:1903506,GO:1990837,GO:2000112,GO:2001141		ko:K05501					ko00000,ko03000,ko03036				Escherichia	1MWF7@1224,1RPZ6@1236,3XNEV@561,COG1309@1,COG1309@2	NA|NA|NA	K	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions
b3642	199310.c4466	1.2e-114	419.1	Escherichia	pyrE	GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2819,iECIAI39_1322.ECIAI39_4161,iEcSMS35_1347.EcSMS35_3977,iUTI89_1310.UTI89_C4186	Escherichia	1MW6F@1224,1RQYG@1236,3XNWG@561,COG0461@1,COG0461@2	NA|NA|NA	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
b3643	155864.EDL933_4904	2e-118	431.8	Escherichia	rph		2.7.7.56	ko:K00989					ko00000,ko01000,ko03016				Escherichia	1MVFZ@1224,1RNTB@1236,3XMIK@561,COG0689@1,COG0689@2	NA|NA|NA	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
b3644	316407.85676399	1.7e-151	542.0	Escherichia	yicC	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575											Escherichia	1MWRA@1224,1RMAB@1236,3XPBQ@561,COG1561@1,COG1561@2	NA|NA|NA	S	Domain of unknown function (DUF1732)
b3645	316407.85676398	9.6e-152	542.7	Gammaproteobacteria													Escherichia	1MVMT@1224,1RYM2@1236,COG3645@1,COG3645@2	NA|NA|NA	S	DNA-damage-inducible protein d
b3646	155864.EDL933_4908	6.6e-105	386.7	Escherichia	yicG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1R9H8@1224,1S00T@1236,3XMVT@561,COG2860@1,COG2860@2	NA|NA|NA	S	UPF0126 domain
b3647	316407.85676396	0.0	1161.0	Escherichia	ligB	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430		R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400				Escherichia	1MUZ1@1224,1RN3F@1236,3XMXN@561,COG0272@1,COG0272@2	NA|NA|NA	L	catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction
b3648	198214.SF3688	5.6e-112	410.2	Gammaproteobacteria													Escherichia	1MW92@1224,1RN09@1236,COG0194@1,COG0194@2	NA|NA|NA	F	Essential for recycling GMP and indirectly, cGMP
b3649	1005994.GTGU_03944	2.7e-34	151.0	Gammaproteobacteria													Escherichia	1N6TX@1224,1SCSR@1236,COG1758@1,COG1758@2	NA|NA|NA	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
b3650	155864.EDL933_4913	0.0	1383.6	Escherichia	spoT	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009987,GO:0015949,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0030312,GO:0034641,GO:0042578,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:1901360	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230		R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009			iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475	Escherichia	1MU44@1224,1RN3H@1236,3XMC5@561,COG0317@1,COG0317@2	NA|NA|NA	F	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
b3651	198214.SF3691	9e-127	459.5	Gammaproteobacteria													Escherichia	1MWBE@1224,1RMPR@1236,COG0566@1,COG0566@2	NA|NA|NA	J	Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA
b3652	316407.85676391	0.0	1352.8	Escherichia	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Escherichia	1MWN2@1224,1RMMQ@1236,3XNNB@561,COG1200@1,COG1200@2	NA|NA|NA	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
b3653	198214.SF3693	2.7e-211	741.1	Gammaproteobacteria													Escherichia	1MVBC@1224,1RP0S@1236,COG0786@1,COG0786@2	NA|NA|NA	P	Catalyzes the sodium-dependent transport of glutamate
b3654	155864.EDL933_4918	6.4e-249	866.3	Escherichia	xanP	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015851,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042906,GO:0042907,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823		ko:K16345					ko00000,ko02000	2.A.40.4.2		iSDY_1059.SDY_4086	Escherichia	1MUN9@1224,1RMGW@1236,3XNJJ@561,COG2233@1,COG2233@2	NA|NA|NA	F	Specific, proton motive force-dependent high-affinity transporter for xanthine
b3655	316407.85676388	0.0	1131.7	Escherichia	yicH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MU7Y@1224,1RN96@1236,3XMHH@561,COG2982@1,COG2982@2	NA|NA|NA	M	AsmA family
b3656	316407.85676387	0.0	1654.8	Escherichia	yicI	GO:0003674,GO:0003824,GO:0004553,GO:0005488,GO:0005515,GO:0016787,GO:0016798,GO:0042802,GO:0080176	3.2.1.177	ko:K01811					ko00000,ko01000		GH31		Escherichia	1MWNJ@1224,1RMJ9@1236,3XMXR@561,COG1501@1,COG1501@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 31 family
b3657	316407.85676386	8.6e-262	909.1	Escherichia	yicJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03292					ko00000	2.A.2			Escherichia	1MVUM@1224,1RP5J@1236,3XN02@561,COG2211@1,COG2211@2	NA|NA|NA	G	sodium ion transport
b3659	316407.85676385	1.8e-215	755.0	Escherichia	setC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03291					ko00000,ko02000	2.A.1.20			Escherichia	1MWWU@1224,1RN2I@1236,3XQFD@561,COG0477@1,COG2814@2	NA|NA|NA	P	sugar efflux transporter
b3660	316407.85676384	1.2e-158	565.8	Escherichia	yicL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1NHTP@1224,1RR5J@1236,3XNDX@561,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
b3661	316407.85676383	6.9e-150	536.6	Escherichia	nlpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02073	ko02010,map02010	M00238			ko00000,ko00001,ko00002,ko02000	3.A.1.24			Escherichia	1MUVY@1224,1RSKH@1236,3XNXN@561,COG1464@1,COG1464@2	NA|NA|NA	M	NLPA lipoprotein
b4555	316407.85676382	1.3e-47	195.3	Escherichia	yicS												Escherichia	1N3XB@1224,1SAN1@1236,2D8BC@1,32TQY@2,3XQ5W@561	NA|NA|NA		
b3662	198214.SF3799	3.6e-208	730.7	Gammaproteobacteria													Escherichia	1MVD0@1224,1RMBW@1236,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b3663	155864.EDL933_4986	3e-78	297.7	Escherichia	yicN												Escherichia	1RBC6@1224,1S3E1@1236,28NJF@1,2ZBKK@2,3XPAP@561	NA|NA|NA	S	Protein of unknown function (DUF1198)
b3664	316407.85676379	4.9e-238	830.1	Escherichia	yicO	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015207,GO:0015851,GO:0015853,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823		ko:K06901					ko00000,ko02000	2.A.1.40		iECOK1_1307.ECOK1_4117,iECUMN_1333.ECUMN_4191,iUTI89_1310.UTI89_C4220	Escherichia	1MUV0@1224,1RMBE@1236,3XPBF@561,COG2252@1,COG2252@2	NA|NA|NA	S	adenine transmembrane transporter activity
b3665	316407.85676378	0.0	1179.5	Escherichia	ade	GO:0000034,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005506,GO:0006040,GO:0006044,GO:0006046,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008448,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016787,GO:0016810,GO:0016811,GO:0016814,GO:0018130,GO:0019213,GO:0019239,GO:0019438,GO:0019439,GO:0030145,GO:0034641,GO:0042221,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046348,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055086,GO:0055114,GO:0070887,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0097237,GO:0098754,GO:0098869,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1990748	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100		R01244	RC00477	ko00000,ko00001,ko01000			iECUMN_1333.ECUMN_4192,iSFV_1184.SFV_3844	Escherichia	1MVFP@1224,1RYZ1@1236,3XPH7@561,COG1001@1,COG1001@2	NA|NA|NA	F	adenine deaminase
b3666	155864.EDL933_4990	2.2e-257	894.4	Escherichia	uhpT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015119,GO:0015291,GO:0015297,GO:0015301,GO:0015315,GO:0015318,GO:0015526,GO:0015605,GO:0015698,GO:0015711,GO:0015712,GO:0015748,GO:0015760,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:0099516,GO:1901264,GO:1901505		ko:K07784	ko02020,map02020				ko00000,ko00001,ko02000	2.A.1.4.1		iECSF_1327.ECSF_3513	Escherichia	1MXY3@1224,1RYKQ@1236,3XM92@561,COG2271@1,COG2271@2	NA|NA|NA	P	Mediates the exchange of external hexose 6-phosphate and internal inorganic phosphate. Can transport glucose-6-phosphate, fructose-6-phosphate and mannose-6-phosphate. Also catalyzes the neutral exchange of internal and external phosphate
b3667	316407.85676376	2.8e-254	884.0	Escherichia	uhpC	GO:0000160,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944		ko:K07783	ko02020,map02020				ko00000,ko00001,ko02000	2.A.1.4.4,2.A.1.4.6			Escherichia	1MX4V@1224,1RMB3@1236,3XN04@561,COG2271@1,COG2271@2	NA|NA|NA	G	Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB
b3668	316407.85676375	7.1e-286	989.2	Escherichia	uhpB	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07675	ko02020,map02020	M00473			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1QUAD@1224,1RMGY@1236,3XP1Q@561,COG3851@1,COG3851@2	NA|NA|NA	T	Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as a membrane-associated protein kinase that autophosphorylates in response to interaction with UhpC, and subsequently transfers its phosphate group to the response regulator UhpA. Can also dephosphorylate UhpA
b3669	155864.EDL933_4993	1.8e-104	385.2	Escherichia	uhpA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K07686	ko02020,map02020	M00473			ko00000,ko00001,ko00002,ko02022				Escherichia	1QW4D@1224,1RVMQ@1236,3XMI5@561,COG2197@1,COG2197@2	NA|NA|NA	K	Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region
b3670	1440052.EAKF1_ch2259	2.7e-48	197.6	Escherichia	ilvN	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iAF1260.b3670,iAPECO1_1312.APECO1_2782,iB21_1397.B21_03496,iBWG_1329.BWG_3361,iE2348C_1286.E2348C_3985,iEC042_1314.EC042_4025,iECABU_c1320.ECABU_c41570,iECBD_1354.ECBD_0033,iECB_1328.ECB_03554,iECDH10B_1368.ECDH10B_3853,iECDH1ME8569_1439.ECDH1ME8569_3555,iECD_1391.ECD_03554,iECED1_1282.ECED1_4366,iECH74115_1262.ECH74115_5103,iECIAI1_1343.ECIAI1_3846,iECIAI39_1322.ECIAI39_4272,iECNA114_1301.ECNA114_3825,iECO111_1330.ECO111_4494,iECO26_1355.ECO26_4913,iECOK1_1307.ECOK1_4123,iECP_1309.ECP_3877,iECS88_1305.ECS88_4095,iECSE_1348.ECSE_3954,iECSF_1327.ECSF_3518,iECSP_1301.ECSP_4721,iECUMN_1333.ECUMN_4201,iECW_1372.ECW_m3968,iECs_1301.ECs4611,iEKO11_1354.EKO11_0033,iETEC_1333.ETEC_3964,iEcDH1_1363.EcDH1_0033,iEcE24377_1341.EcE24377A_4179,iEcHS_1320.EcHS_A3883,iEcSMS35_1347.EcSMS35_4037,iEcolC_1368.EcolC_0029,iG2583_1286.G2583_4464,iJO1366.b3670,iJR904.b3670,iLF82_1304.LF82_1110,iNRG857_1313.NRG857_18305,iSSON_1240.SSON_3624,iUMN146_1321.UM146_18560,iUMNK88_1353.UMNK88_4479,iUTI89_1310.UTI89_C4226,iWFL_1372.ECW_m3968,iY75_1357.Y75_RS18770,iZ_1308.Z5164,ic_1306.c4595	Escherichia	1N065@1224,1S73I@1236,3XPW8@561,COG0440@1,COG0440@2	NA|NA|NA	E	acetolactate synthase
b3671	316407.85676372	0.0	1120.1	Escherichia	ilvB	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_4155	Escherichia	1MU6U@1224,1RMQQ@1236,3XM7M@561,COG0028@1,COG0028@2	NA|NA|NA	H	acetolactate synthase
b3673	316407.85676370	8e-216	756.1	Escherichia	emrD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08154					ko00000,ko02000	2.A.1.2.9			Escherichia	1N0VD@1224,1RN3X@1236,3XPF0@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b3674	316407.85676369	5.5e-94	350.1	Escherichia	yidF			ko:K06871					ko00000				Escherichia	1MX3M@1224,1S9YT@1236,3XQKE@561,COG0641@1,COG0641@2	NA|NA|NA	K	catalytic activity
b3675	155864.EDL933_5002	6.5e-60	236.5	Escherichia	yidG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RJVC@1224,1S5YN@1236,2ATH5@1,31J0W@2,3XPVT@561	NA|NA|NA	S	Domain of unknown function (DUF202)
b3676	155864.EDL933_5003	7.8e-55	219.5	Escherichia	yidH	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944		ko:K00389					ko00000				Escherichia	1REUC@1224,1S618@1236,3XPRM@561,COG2149@1,COG2149@2	NA|NA|NA	S	response to oxidative stress
b3677	316407.85676366	1.7e-73	282.0	Escherichia	yidI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RHWJ@1224,1S6BM@1236,2B6XT@1,31ZXV@2,3XPNI@561	NA|NA|NA		
b3678	316407.85676365	1e-308	1065.1	Escherichia	yidJ			ko:K01138					ko00000,ko01000				Escherichia	1MV0B@1224,1RMJ0@1236,3XQGB@561,COG3119@1,COG3119@2	NA|NA|NA	P	sulfuric ester hydrolase activity
b3679	316407.85676364	0.0	1104.4	Gammaproteobacteria													Escherichia	1MXWV@1224,1RR4S@1236,COG4146@1,COG4146@2	NA|NA|NA	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
b3680	316407.85676363	6.7e-175	619.8	Escherichia	yidL	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1R5IW@1224,1S033@1236,3XRCD@561,COG2207@1,COG2207@2	NA|NA|NA	K	sequence-specific DNA binding
b3681	469008.B21_03508	2.3e-113	414.8	Escherichia	glvA		3.2.1.122	ko:K01232	ko00500,map00500		R00837,R00838,R06113	RC00049	ko00000,ko00001,ko01000		GH4		Escherichia	1NI6G@1224,1RYKZ@1236,3XP52@561,COG1486@1,COG1486@2	NA|NA|NA	G	Family 4 glycosyl hydrolase
b3682	155864.EDL933_5009	3.6e-82	310.8	Escherichia		GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071944	2.7.1.208	ko:K02749,ko:K02750	ko00500,ko02060,map00500,map02060	M00268	R04111	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.10,4.A.1.1.16,4.A.1.1.4,4.A.1.1.8			Escherichia	1MU2P@1224,1RNF4@1236,3XP6Q@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	Phosphotransferase system, EIIC
b3683	316407.85676361	1.3e-204	718.8	Escherichia		GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071944	2.7.1.208	ko:K02749,ko:K02750	ko00500,ko02060,map00500,map02060	M00268	R04111	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.10,4.A.1.1.16,4.A.1.1.4,4.A.1.1.8			Escherichia	1MU2P@1224,1RNF4@1236,3XP6Q@561,COG1263@1,COG1263@2	NA|NA|NA	G	Phosphotransferase system, EIIC
b3684	316407.85676360	4.2e-127	460.7	Escherichia	yidP	GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0051179,GO:0051234,GO:0071702,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K03482					ko00000,ko03000				Escherichia	1MUEB@1224,1RN2J@1236,3XQQU@561,COG2188@1,COG2188@2	NA|NA|NA	K	transcriptional regulator
b3685	155864.EDL933_5011	9.9e-297	1025.4	Escherichia	yidE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07085					ko00000	2.A.81			Escherichia	1MUVM@1224,1RQY2@1236,3XNHV@561,COG0569@1,COG0569@2,COG2985@1,COG2985@2	NA|NA|NA	P	potassium ion transport
b3686	155864.EDL933_5013	1e-75	289.3	Escherichia	ibpB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0010035,GO:0010038,GO:0042221,GO:0042802,GO:0044424,GO:0044464,GO:0046688,GO:0050896,GO:0097501,GO:1990169		ko:K04081					ko00000,ko03110				Escherichia	1R9Z9@1224,1S23Z@1236,3XP7K@561,COG0071@1,COG0071@2	NA|NA|NA	O	Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent
b3687	1440052.EAKF1_ch2245	1.1e-71	275.8	Escherichia	ibpA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896		ko:K04080					ko00000,ko03110				Escherichia	1RH2X@1224,1S6WS@1236,3XPM8@561,COG0071@1,COG0071@2	NA|NA|NA	O	Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent
b3688	198214.SF3775	9.8e-55	219.2	Gammaproteobacteria													Escherichia	1MZ8R@1224,1S9TX@1236,COG5645@1,COG5645@2	NA|NA|NA	S	(Lipo)protein
b3689	511145.b3689	2.3e-258	897.5	Escherichia	yidR	GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019586,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046397,GO:0071704,GO:0072329,GO:1901575											Escherichia	1MWDT@1224,1RMFV@1236,3XMAC@561,COG0823@1,COG0823@2	NA|NA|NA	U	galacturonate metabolic process
b3690	316407.85676354	1.7e-209	734.9	Escherichia	cbrA	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0008152,GO:0009404,GO:0009987,GO:0019748,GO:0030153,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0048037,GO:0050660,GO:0050662,GO:0097159,GO:1901265,GO:1901363											Escherichia	1MXQY@1224,1RZ79@1236,3XM79@561,COG0644@1,COG0644@2	NA|NA|NA	C	bacteriocin immunity
b3691	199310.c4612	3.3e-247	860.5	Escherichia	dgoT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K08194					ko00000,ko02000	2.A.1.14.7		iECO103_1326.ECO103_4467	Escherichia	1MVPS@1224,1RNMV@1236,3XMSP@561,COG2271@1,COG2271@2	NA|NA|NA	P	Intake of galactonate into the cell
b4478	316407.85676352	4.4e-227	793.5	Escherichia	dgoD	GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034192,GO:0034194,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000			iAF1260.b4478,iB21_1397.B21_03519,iBWG_1329.BWG_3382,iEC042_1314.EC042_4048,iEC55989_1330.EC55989_4161,iECBD_1354.ECBD_0011,iECB_1328.ECB_03575,iECDH10B_1368.ECDH10B_3878,iECDH1ME8569_1439.ECDH1ME8569_3579,iECD_1391.ECD_03575,iECIAI1_1343.ECIAI1_3870,iECO103_1326.ECO103_4466,iECO111_1330.ECO111_4519,iECSE_1348.ECSE_3978,iECUMN_1333.ECUMN_4223,iECW_1372.ECW_m3991,iEKO11_1354.EKO11_0011,iETEC_1333.ETEC_3982,iEcDH1_1363.EcDH1_0011,iEcE24377_1341.EcE24377A_4201,iEcSMS35_1347.EcSMS35_4057,iEcolC_1368.EcolC_0011,iJO1366.b4478,iWFL_1372.ECW_m3991,iY75_1357.Y75_RS18645	Escherichia	1MURK@1224,1RPIT@1236,3XMIV@561,COG4948@1,COG4948@2	NA|NA|NA	M	Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate
b4477	316407.85676351	8.9e-110	402.9	Escherichia	dgoA	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008674,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034192,GO:0034194,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0071704,GO:0072329,GO:1901575	4.1.2.21	ko:K01631	ko00052,ko01100,map00052,map01100	M00552	R01064	RC00307,RC00435	ko00000,ko00001,ko00002,ko01000			iECIAI1_1343.ECIAI1_3871,iECO103_1326.ECO103_4465,iECO111_1330.ECO111_4520,iECO26_1355.ECO26_4889,iECW_1372.ECW_m3992,iEKO11_1354.EKO11_0010,iEcE24377_1341.EcE24377A_4202,iUMNK88_1353.UMNK88_4503,iWFL_1372.ECW_m3992	Escherichia	1RD0T@1224,1RQMK@1236,3XP06@561,COG0800@1,COG0800@2	NA|NA|NA	G	Involved in the degradation of galactose via the DeLey- Doudoroff pathway. Catalyzes the reversible, stereospecific retro- aldol cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) to pyruvate and D-glyceraldehyde-3-phosphate. In the synthetic direction, it catalyzes the addition of pyruvate to electrophilic aldehydes with re-facial selectivity. It can use a limited number of aldehyde substrates, including D-glyceraldehyde-3-phosphate (natural substrate), D-glyceraldehyde, glycolaldehyde, 2- pyridinecarboxaldehyde, D-ribose, D-erythrose and D-threose. It efficiently catalyzes aldol addition only using pyruvate as the nucleophilic component and accepts both stereochemical configurations at C2 of the electrophile
b3693	316407.85676350	8.7e-167	592.8	Escherichia	dgoK	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008671,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034192,GO:0034194,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0046835,GO:0071704,GO:0072329,GO:1901575	2.7.1.58	ko:K00883	ko00052,ko01100,map00052,map01100	M00552	R03387	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c41760,iECSE_1348.ECSE_3980,iLF82_1304.LF82_0474,iNRG857_1313.NRG857_18400	Escherichia	1MWGX@1224,1RYZB@1236,3XM75@561,COG3734@1,COG3734@2	NA|NA|NA	G	2-dehydro-3-deoxygalactonokinase activity
b4479	198214.SF3769	2.1e-123	448.4	Gammaproteobacteria													Escherichia	1MV83@1224,1RSDC@1236,COG2186@1,COG2186@2	NA|NA|NA	K	transcriptional
b3696	198214.SF3768	1.2e-120	439.1	Gammaproteobacteria													Escherichia	1RJVW@1224,1S89V@1236,2BBJI@1,3253A@2	NA|NA|NA		
b3697	198214.SF3767	1.1e-147	529.3	Gammaproteobacteria													Escherichia	1MXIH@1224,1RQH8@1236,COG0561@1,COG0561@2	NA|NA|NA	S	member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins
b3698	316407.85676346	9.6e-65	252.7	Escherichia	yidB												Escherichia	1N7FF@1224,1S9KM@1236,3XPQ2@561,COG3753@1,COG3753@2	NA|NA|NA	S	Bacterial protein of unknown function (DUF937)
b3699	155864.EDL933_5022	0.0	1595.1	Escherichia	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470					ko00000,ko01000,ko03032,ko03400				Escherichia	1MVKT@1224,1RNB2@1236,3XM6W@561,COG0187@1,COG0187@2	NA|NA|NA	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
b3700	155864.EDL933_5023	1.4e-203	715.3	Escherichia	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576		ko:K03629	ko03440,map03440				ko00000,ko00001,ko03400				Escherichia	1MX8N@1224,1RN5P@1236,3XNSR@561,COG1195@1,COG1195@2	NA|NA|NA	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
b3701	155864.EDL933_5024	3.1e-206	724.2	Escherichia	dnaN	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Escherichia	1MVD9@1224,1RMNP@1236,3XMYP@561,COG0592@1,COG0592@2	NA|NA|NA	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
b3702	316407.85676342	1.4e-264	918.3	Escherichia	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112		ko:K02313	ko02020,ko04112,map02020,map04112				ko00000,ko00001,ko03032,ko03036				Escherichia	1MU5H@1224,1RNHP@1236,3XNWU@561,COG0593@1,COG0593@2	NA|NA|NA	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
b3703	1005994.GTGU_04003	4.1e-15	86.3	Gammaproteobacteria													Escherichia	1NGGS@1224,1SGDJ@1236,COG0230@1,COG0230@2	NA|NA|NA	J	Belongs to the bacterial ribosomal protein bL34 family
b3704	754331.AEME01000001_gene1895	3.2e-59	234.2	Escherichia	rnpA	GO:0000966,GO:0001682,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0099116,GO:1901360	3.1.26.5	ko:K03536					ko00000,ko01000,ko03016				Escherichia	1MZQE@1224,1S90M@1236,3XPNX@561,COG0594@1,COG0594@2	NA|NA|NA	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
b4557	316407.85676339	4.2e-45	186.8	Gammaproteobacteria													Escherichia	1N6U4@1224,1SCG6@1236,COG0759@1,COG0759@2	NA|NA|NA	S	Could be involved in insertion of integral membrane proteins into the membrane
b3705	316407.85676338	7e-303	1045.8	Escherichia	yidC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150		ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9			Escherichia	1MV5M@1224,1RMH1@1236,3XN50@561,COG0706@1,COG0706@2	NA|NA|NA	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
b3706	316407.85676337	6.5e-254	882.9	Escherichia	mnmE	GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363		ko:K03650			R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016				Escherichia	1MUCQ@1224,1RN5S@1236,3XNA1@561,COG0486@1,COG0486@2	NA|NA|NA	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
b3708	198214.SF3754	2e-274	951.0	Gammaproteobacteria													Escherichia	1NG5U@1224,1RS6E@1236,COG3033@1,COG3033@2	NA|NA|NA	E	Belongs to the beta-eliminating lyase family
b3709	511145.b3709	8.9e-234	815.8	Escherichia	tnaB	GO:0003333,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0015291,GO:0015293,GO:0015711,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K03836					ko00000,ko02000	2.A.42.1.3		iEC042_1314.EC042_4066,iSFV_1184.SFV_3804,iSFxv_1172.SFxv_4080,iS_1188.S4018	Escherichia	1MWGI@1224,1RMME@1236,3XPAV@561,COG0814@1,COG0814@2	NA|NA|NA	E	Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically
b3710	316407.85676330	2.6e-206	724.5	Escherichia	mdtL	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015893,GO:0016020,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K08163					ko00000,ko02000	2.A.1.2.22			Escherichia	1P8JD@1224,1T1SC@1236,3XMTT@561,COG0477@1,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b3711	316407.85676329	5e-184	650.2	Escherichia	yidZ	GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Escherichia	1R4F5@1224,1RRRX@1236,3XNGP@561,COG0583@1,COG0583@2	NA|NA|NA	K	Involved in anaerobic NO protection
b3712	199310.c4635	9.7e-143	512.7	Escherichia	yieE	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607											Escherichia	1PH34@1224,1RP3Q@1236,3XPI6@561,COG2091@1,COG2091@2	NA|NA|NA	H	lysine biosynthetic process via aminoadipic acid
b3713	155864.EDL933_5038	4.1e-101	374.0	Escherichia	yieF	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006805,GO:0008150,GO:0008152,GO:0009410,GO:0009987,GO:0010181,GO:0016491,GO:0016645,GO:0016646,GO:0032553,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0052873,GO:0055114,GO:0070887,GO:0071466,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K19784					ko00000				Escherichia	1RAFI@1224,1RYNR@1236,3XP8R@561,COG0431@1,COG0431@2	NA|NA|NA	S	Can also reduce toxic chromate to insoluble and less toxic Cr(3 ). Catalyzes the transfer of three electrons to Cr(6 ) producing Cr(3 ) and one electron to molecular oxygen without producing the toxic Cr(5 ) species and only producing a minimal amount of reactive oxygen species (ROS). Chromate reduction protects the cell against chromate toxicity, but is likely a secondary activity
b3714	316407.85676324	3.5e-236	823.9	Escherichia	purP	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006863,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015205,GO:0015207,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015851,GO:0015853,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904823		ko:K06901					ko00000,ko02000	2.A.1.40		iECH74115_1262.ECH74115_5145,iECSP_1301.ECSP_4762,iECs_1301.ECs4651,iG2583_1286.G2583_4505,iJO1366.b3714,iY75_1357.Y75_RS18500,iZ_1308.Z5209	Escherichia	1MUV0@1224,1RMBE@1236,3XNC6@561,COG2252@1,COG2252@2	NA|NA|NA	S	Belongs to the xanthine uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily
b3715	316407.85676323	2.5e-126	458.0	Escherichia	yieH	GO:0000287,GO:0003674,GO:0003824,GO:0003850,GO:0004346,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050308,GO:0050309											Escherichia	1NSPA@1224,1RQET@1236,3XMUW@561,COG0637@1,COG0637@2	NA|NA|NA	S	Catalyzes strongly the dephosphorylation of 6- phosphogluconate (6P-Glu) and slightly the dephosphorylation of dihydroxyacetone phosphate (DHAP) and phosphoenolpyruvate (PEP). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates
b3716	198214.SF3744	7.3e-72	276.6	Gammaproteobacteria													Escherichia	1NJZ6@1224,1SID8@1236,2ERDW@1,33IZG@2	NA|NA|NA		
b3717	316407.85676321	1.2e-119	435.6	Escherichia	cbrC	GO:0008150,GO:0008152,GO:0009404,GO:0009987,GO:0019748,GO:0030153,GO:0044237		ko:K09925					ko00000				Escherichia	1RC5N@1224,1S2QQ@1236,3XQTG@561,COG3196@1,COG3196@2	NA|NA|NA	S	bacteriocin immunity
b3718	316407.85676320	1.2e-134	485.7	Gammaproteobacteria													Escherichia	1PJ4E@1224,1S1EI@1236,COG0363@1,COG0363@2	NA|NA|NA	G	glucosamine-6-phosphate deaminase activity
b3719	316407.85676319	1.4e-225	788.5	Gammaproteobacteria													Escherichia	1QU4Q@1224,1RZ98@1236,COG2382@1,COG2382@2	NA|NA|NA	P	Belongs to the glycosyl hydrolase 13 family
b3720	316407.85676318	0.0	1085.9	Gammaproteobacteria													Escherichia	1PNS3@1224,1RQTQ@1236,COG4580@1,COG4580@2	NA|NA|NA	M	PFAM porin LamB type
b3721	316407.85676317	3.7e-284	983.4	Escherichia	bglB	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008422,GO:0008706,GO:0015926,GO:0016787,GO:0016798,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901657	3.2.1.86	ko:K01223	ko00010,ko00500,map00010,map00500		R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000		GT1		Escherichia	1MWG6@1224,1RMM2@1236,3XNCY@561,COG2723@1,COG2723@2	NA|NA|NA	G	Catalyzes the hydrolysis of phosphorylated beta- glucosides into glucose-6-phosphate (G-6-P) and aglycone. It has a high affinity for phosphorylated aromatic beta-glucosides (p- nitrophenyl-beta-glucoside, phenyl beta-glucoside, arbutin and phosphorylated salicin), and a low affinity for phosphorylated beta-methyl-glucoside
b3722	316407.85676316	0.0	1222.2	Escherichia	bglF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563		ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	M00271			ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6		iE2348C_1286.E2348C_4032,iEcHS_1320.EcHS_A3936	Escherichia	1MXEG@1224,1RNEG@1236,3XMAD@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2,COG2190@1,COG2190@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in beta-glucoside transport
b3723	316407.85676315	1.4e-142	512.3	Escherichia	bglG	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0097159,GO:1901363		ko:K03488					ko00000,ko03000				Escherichia	1NHN8@1224,1RR9W@1236,3XR5Z@561,COG3711@1,COG3711@2	NA|NA|NA	K	Mediates the positive regulation of the beta-glucoside (bgl) operon by functioning as a transcriptional antiterminator. This is an RNA-binding protein that recognizes a specific sequence located just upstream of two termination sites within the operon
b3724	198214.SF3731	7e-130	469.9	Gammaproteobacteria													Escherichia	1MUMI@1224,1RMW5@1236,COG0704@1,COG0704@2	NA|NA|NA	P	Plays a role in the regulation of phosphate uptake
b3725	155864.EDL933_5048	5.7e-146	523.5	Escherichia	pstB	GO:0000166,GO:0003674,GO:0005215,GO:0005315,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008144,GO:0008150,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0017076,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035303,GO:0035435,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0097159,GO:0097367,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363	3.6.3.27	ko:K02036	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7			Escherichia	1MU16@1224,1RNUF@1236,3XNH7@561,COG1117@1,COG1117@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system
b3726	316407.85676312	1.4e-156	558.9	Escherichia	pstA	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661		ko:K02038	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7		iZ_1308.Z5217	Escherichia	1MUWB@1224,1S1FS@1236,3XRKA@561,COG0581@1,COG0581@2	NA|NA|NA	P	probably responsible for the translocation of the substrate across the membrane
b3727	155864.EDL933_5050	9.1e-170	602.8	Escherichia	pstC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0009314,GO:0009628,GO:0010921,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661		ko:K02037	ko02010,map02010	M00222			ko00000,ko00001,ko00002,ko02000	3.A.1.7		ic_1306.c4652	Escherichia	1MVKP@1224,1RQXJ@1236,3XM5Y@561,COG0573@1,COG0573@2	NA|NA|NA	P	probably responsible for the translocation of the substrate across the membrane
b3728	198214.SF3727	2.3e-195	688.0	Gammaproteobacteria													Escherichia	1MUAZ@1224,1RN5Q@1236,COG0226@1,COG0226@2	NA|NA|NA	P	Part of the ABC transporter complex PstSACB involved in phosphate import
b3729	316407.85676309	0.0	1192.6	Escherichia	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009987,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931		R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002			iE2348C_1286.E2348C_4039,iEC042_1314.EC042_4115,iECIAI39_1322.ECIAI39_4333,iECNA114_1301.ECNA114_3878,iECOK1_1307.ECOK1_4178,iECSF_1327.ECSF_3577,iECUMN_1333.ECUMN_4259,iEcSMS35_1347.EcSMS35_4097,iLF82_1304.LF82_0844,iNRG857_1313.NRG857_18570,iSFV_1184.SFV_3755,iSF_1195.SF3809,iSFxv_1172.SFxv_4151,iS_1188.S3959,iUMN146_1321.UM146_18835,iUTI89_1310.UTI89_C4281	Escherichia	1MW4K@1224,1RMVN@1236,3XMF7@561,COG0449@1,COG0449@2	NA|NA|NA	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
b3730	155864.EDL933_5060	1.6e-247	861.7	Escherichia	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0018130,GO:0019134,GO:0019438,GO:0034641,GO:0034654,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046872,GO:0055086,GO:0070569,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_4420	Escherichia	1MUPH@1224,1RNKE@1236,3XP6N@561,COG1207@1,COG1207@2	NA|NA|NA	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
b3731	199310.c4657	3e-69	267.7	Escherichia	atpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1		iSbBS512_1146.SbBS512_E4190	Escherichia	1RHE4@1224,1S25H@1236,3XM4A@561,COG0355@1,COG0355@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane
b3732	1440052.EAKF1_ch2201	2.3e-259	901.0	Escherichia	atpD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045261,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902600	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1		e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658	Escherichia	1MUFU@1224,1RN6U@1236,3XPEM@561,COG0055@1,COG0055@2	NA|NA|NA	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
b3733	155864.EDL933_5063	2e-155	555.1	Escherichia	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045261,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902600		ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1		iSSON_1240.SSON_3886	Escherichia	1MU28@1224,1RNWJ@1236,3XPI3@561,COG0224@1,COG0224@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
b3734	1440052.EAKF1_ch2199	1.5e-286	991.5	Escherichia	atpA	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1		iSbBS512_1146.SbBS512_E4187	Escherichia	1MUG7@1224,1RP4V@1236,3XP3D@561,COG0056@1,COG0056@2	NA|NA|NA	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
b3735	155864.EDL933_5065	1.8e-87	328.6	Escherichia	atpH	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045261,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902600		ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1		iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953	Escherichia	1MVRH@1224,1S8X2@1236,3XMJ4@561,COG0712@1,COG0712@2	NA|NA|NA	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
b3736	754331.AEME01000001_gene1918	8.4e-52	209.9	Escherichia	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902600		ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194	3.A.2.1		e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664	Escherichia	1RHZ0@1224,1S402@1236,3XNMY@561,COG0711@1,COG0711@2	NA|NA|NA	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
b3737	1005994.GTGU_04025	3.8e-32	143.7	Gammaproteobacteria													Escherichia	1N1NA@1224,1S9MD@1236,32S3K@2,COG0636@1	NA|NA|NA	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
b3738	155864.EDL933_5068	2.4e-147	528.1	Escherichia	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600		ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157			ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1		iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666	Escherichia	1MV87@1224,1RPHK@1236,3XMPD@561,COG0356@1,COG0356@2	NA|NA|NA	C	it plays a direct role in the translocation of protons across the membrane
b3739	198214.SF3819	2.8e-53	214.5	Gammaproteobacteria													Escherichia	1RITN@1224,1S767@1236,COG3312@1,COG3312@2	NA|NA|NA	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation
b3740	155864.EDL933_5070	7.9e-114	416.4	Escherichia	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501					ko00000,ko01000,ko03009,ko03036				Escherichia	1MY0K@1224,1RMRZ@1236,3XMZH@561,COG0357@1,COG0357@2	NA|NA|NA	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA
b3741	199310.c4669	0.0	1243.8	Escherichia	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363		ko:K03495			R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036				Escherichia	1MU6F@1224,1RMM1@1236,3XNZB@561,COG0445@1,COG0445@2	NA|NA|NA	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
b3742	316407.85676296	3.1e-80	304.3	Escherichia	mioC	GO:0000166,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0010181,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0051302,GO:0065007,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K06205					ko00000				Escherichia	1N30T@1224,1S403@1236,3XP8U@561,COG0716@1,COG0716@2	NA|NA|NA	C	electron transporter required for biotin synthase activity
b3743	155864.EDL933_5073	1.8e-78	298.5	Escherichia	asnC	GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016597,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031406,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043177,GO:0043200,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141		ko:K03718					ko00000,ko03000				Escherichia	1MWPX@1224,1RRPA@1236,3XM6Y@561,COG1522@1,COG1522@2	NA|NA|NA	K	and repressor of the expression of gidA at a post-transcriptional level
b3744	316407.85676294	8.8e-192	676.0	Escherichia	asnA	GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230		R00483	RC00010	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299	Escherichia	1MVWF@1224,1RN79@1236,3XNFG@561,COG2502@1,COG2502@2	NA|NA|NA	F	aspartate--ammonia ligase
b3745	155864.EDL933_5075	2.5e-272	944.1	Escherichia	viaA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0016020,GO:0032781,GO:0043085,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051336,GO:0051345,GO:0065007,GO:0065009											Escherichia	1N1RQ@1224,1RPQT@1236,3XNVH@561,COG2425@1,COG2425@2	NA|NA|NA	S	VWA domain protein interacting with AAA ATPase
b3746	316407.85676292	2.8e-282	977.2	Escherichia	ravA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0042802,GO:0044424,GO:0044444,GO:0044464		ko:K03924					ko00000,ko01000				Escherichia	1PC08@1224,1RQ5U@1236,3XMMQ@561,COG0714@1,COG0714@2	NA|NA|NA	S	Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone
b3747	199310.c4675	0.0	1209.1	Escherichia	kup	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K03549					ko00000,ko02000	2.A.72		iECs_1301.ECs4689,iG2583_1286.G2583_4543,iZ_1308.Z5248	Escherichia	1MUVH@1224,1RPM6@1236,3XMNU@561,COG3158@1,COG3158@2	NA|NA|NA	P	Responsible for the low-affinity transport of potassium into the cell, with the
b3748	155864.EDL933_5078	2.7e-70	271.2	Escherichia	rbsD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0016853,GO:0016866,GO:0019303,GO:0019321,GO:0019323,GO:0042802,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0071704,GO:1901575	5.4.99.62	ko:K06726	ko02010,map02010		R08247	RC02247	ko00000,ko00001,ko01000			iAF1260.b3748,iBWG_1329.BWG_3439,iECDH10B_1368.ECDH10B_3936,iECDH1ME8569_1439.ECDH1ME8569_3636,iECH74115_1262.ECH74115_5184,iECSP_1301.ECSP_4798,iECs_1301.ECs4690,iETEC_1333.ETEC_4039,iEcDH1_1363.EcDH1_4219,iJO1366.b3748,iJR904.b3748,iY75_1357.Y75_RS18330	Escherichia	1RI53@1224,1S60T@1236,3XPJ3@561,COG1869@1,COG1869@2	NA|NA|NA	G	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose
b3749	316407.85676289	6.2e-282	976.1	Escherichia	rbsA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.17	ko:K10441	ko02010,map02010	M00212			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19		iEC55989_1330.EC55989_4224,iECSE_1348.ECSE_4039,iECW_1372.ECW_m4052,iEcE24377_1341.EcE24377A_4265,iWFL_1372.ECW_m4052	Escherichia	1MU22@1224,1RMCH@1236,3XN9K@561,COG1129@1,COG1129@2	NA|NA|NA	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
b3750	155864.EDL933_5080	1.5e-151	542.3	Escherichia	rbsC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015591,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034219,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K10440	ko02010,map02010	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19		iAF1260.b3750,iAPECO1_1312.APECO1_2713,iB21_1397.B21_03581,iBWG_1329.BWG_3441,iE2348C_1286.E2348C_4060,iEC042_1314.EC042_4137,iEC55989_1330.EC55989_4225,iECABU_c1320.ECABU_c42350,iECBD_1354.ECBD_4280,iECB_1328.ECB_03636,iECDH10B_1368.ECDH10B_3938,iECDH1ME8569_1439.ECDH1ME8569_3638,iECED1_1282.ECED1_4440,iECH74115_1262.ECH74115_5186,iECIAI1_1343.ECIAI1_3934,iECNA114_1301.ECNA114_3899,iECO103_1326.ECO103_4407,iECO111_1330.ECO111_4584,iECO26_1355.ECO26_4828,iECOK1_1307.ECOK1_4199,iECS88_1305.ECS88_4172,iECSE_1348.ECSE_4040,iECSF_1327.ECSF_3598,iECSP_1301.ECSP_4800,iECUMN_1333.ECUMN_4280,iECs_1301.ECs4692,iEcDH1_1363.EcDH1_4217,iEcE24377_1341.EcE24377A_4266,iEcHS_1320.EcHS_A3966,iEcSMS35_1347.EcSMS35_4118,iEcolC_1368.EcolC_4244,iJO1366.b3750,iJR904.b3750,iLF82_1304.LF82_1817,iNRG857_1313.NRG857_18675,iUMN146_1321.UM146_18940,iUMNK88_1353.UMNK88_4562,iUTI89_1310.UTI89_C4305,iY75_1357.Y75_RS18320,ic_1306.c4678	Escherichia	1MX7D@1224,1RNTS@1236,3XN9E@561,COG1172@1,COG1172@2	NA|NA|NA	G	Part of the ABC transporter complex RbsABC involved in ribose import. Probably responsible for the translocation of the substrate across the membrane
b3751	316407.85676287	4.5e-155	553.9	Escherichia	rbsB	GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006935,GO:0008150,GO:0008643,GO:0009605,GO:0015144,GO:0015145,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0040011,GO:0042221,GO:0042330,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0050896,GO:0050918,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K10439	ko02010,ko02030,map02010,map02030	M00212			ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19			Escherichia	1NRXG@1224,1RPBV@1236,3XMWE@561,COG1879@1,COG1879@2	NA|NA|NA	G	Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose. Also serves as the primary chemoreceptor for chemotaxis
b3752	155864.EDL933_5082	1.1e-164	585.9	Escherichia	rbsK	GO:0003674,GO:0003824,GO:0004747,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019303,GO:0019321,GO:0019323,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046835,GO:0071704,GO:1901575	2.7.1.15	ko:K00852	ko00030,map00030		R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_4062,iEcDH1_1363.EcDH1_4215	Escherichia	1MV5B@1224,1RNVY@1236,3XNNI@561,COG0524@1,COG0524@2	NA|NA|NA	F	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
b3753	199310.c4681	1.6e-185	655.2	Escherichia	rbsR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K02529					ko00000,ko03000				Escherichia	1MVUR@1224,1RN2K@1236,3XNVG@561,COG1609@1,COG1609@2	NA|NA|NA	K	Transcriptional repressor for the ribose rbsDACBK operon. RbsR binds to a region of perfect dyad symmetry spanning the rbs operon transcriptional start site. The affinity for the rbs operator is reduced by addition of ribose, consistent with ribose being the inducer of the operon
b3754	316407.85676284	7.8e-250	869.4	Escherichia	hsrA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944											Escherichia	1QTWJ@1224,1T1QY@1236,3XNAU@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Major facilitator superfamily
b3755	155864.EDL933_5085	1e-125	456.1	Escherichia	yieP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MV83@1224,1RR9F@1236,3XM43@561,COG2186@1,COG2186@2	NA|NA|NA	K	DNA-binding transcription factor activity
b4480	198214.SF3839	5e-156	557.0	Gammaproteobacteria													Escherichia	1MXXA@1224,1RREE@1236,COG0583@1,COG0583@2	NA|NA|NA	K	Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon
b3764	155864.EDL933_5087	4.1e-48	197.2	Escherichia	yifE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0044424,GO:0044444,GO:0044464,GO:0051276,GO:0071840		ko:K09897					ko00000				Escherichia	1RD72@1224,1S3NW@1236,3XPT4@561,COG3085@1,COG3085@2	NA|NA|NA	S	Belongs to the UPF0438 family
b3765	316407.85676280	1.9e-286	991.1	Escherichia	yifB	GO:0003674,GO:0003824,GO:0004176,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0042623,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564		ko:K07391					ko00000				Escherichia	1MU4R@1224,1RMB9@1236,3XMW9@561,COG0606@1,COG0606@2	NA|NA|NA	O	ATP-dependent peptidase activity
b4488	469008.B21_03595	2.2e-184	652.1	Escherichia	ilvG		2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000				Escherichia	1MU6U@1224,1RMQQ@1236,3XMNP@561,COG0028@1,COG0028@2	NA|NA|NA	H	Thiamine pyrophosphate enzyme, central domain
b3769	1440052.EAKF1_ch2172c	7e-40	169.5	Escherichia	ilvM	GO:0003674,GO:0003824,GO:0003984,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576	2.2.1.6	ko:K11258	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000				Escherichia	1MZ9W@1224,1S8VQ@1236,3XPY7@561,COG3978@1,COG3978@2	NA|NA|NA	E	acetolactate synthase activity
b3770	155864.EDL933_5091	8e-179	632.9	Escherichia	ilvE	GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006532,GO:0006551,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007			iB21_1397.B21_03597,iECBD_1354.ECBD_4269,iECB_1328.ECB_03648,iECD_1391.ECD_03648,iECO103_1326.ECO103_4394	Escherichia	1MVB0@1224,1RP6Z@1236,3XMH2@561,COG0115@1,COG0115@2	NA|NA|NA	E	Acts on leucine, isoleucine and valine
b3771	316407.85676276	0.0	1214.5	Escherichia	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_3015	Escherichia	1MUTQ@1224,1RMP2@1236,3XNTA@561,COG0129@1,COG0129@2	NA|NA|NA	E	Dihydroxy-acid dehydratase
b3772	316407.85676275	5.4e-297	1026.2	Escherichia	ilvA	GO:0003674,GO:0003824,GO:0004794,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009081,GO:0009082,GO:0009097,GO:0009987,GO:0016053,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2699	Escherichia	1MVWJ@1224,1RMY6@1236,3XN65@561,COG1171@1,COG1171@2	NA|NA|NA	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
b3773	316407.85676274	2e-166	591.7	Escherichia	ilvY	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464		ko:K02521					ko00000,ko03000				Escherichia	1MZX1@1224,1RNFR@1236,3XMHE@561,COG0583@1,COG0583@2	NA|NA|NA	K	transcriptional regulator IlvY
b3774	316407.85676273	5e-284	983.0	Escherichia	ilvC	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_4152,iECABU_c1320.ECABU_c42560,iECED1_1282.ECED1_4460,iECO103_1326.ECO103_4390,iECO111_1330.ECO111_4600,iECO26_1355.ECO26_4812,iECP_1309.ECP_3967,iECSE_1348.ECSE_4057,iECUMN_1333.ECUMN_4300,iEcE24377_1341.EcE24377A_4285,iEcSMS35_1347.EcSMS35_4140,iLF82_1304.LF82_1103	Escherichia	1MV7M@1224,1RNA8@1236,3XMWQ@561,COG0059@1,COG0059@2	NA|NA|NA	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
b3775	1218086.BBNB01000018_gene1192	6.4e-47	193.0	Citrobacter													Escherichia	1MZDK@1224,1S9DN@1236,3WYKX@544,COG0760@1,COG0760@2	NA|NA|NA	O	PPIC-type PPIASE domain
b3777	469008.B21_03604	3.3e-34	151.4	Bacteria													Escherichia	COG3692@1,COG3692@2	NA|NA|NA	S	DNA binding
b3778	316407.85676270	0.0	1334.3	Escherichia	rep	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044786,GO:0044787,GO:0046483,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03656					ko00000,ko01000,ko03400				Escherichia	1MU0G@1224,1RNJI@1236,3XMV2@561,COG0210@1,COG0210@2	NA|NA|NA	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction
b3779	155864.EDL933_5099	4.3e-267	926.8	Escherichia	gppA	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008894,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031667,GO:0034641,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:1901360	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230		R03409	RC00002	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c42590,iECED1_1282.ECED1_4463	Escherichia	1MV35@1224,1RN3V@1236,3XMDD@561,COG0248@1,COG0248@2	NA|NA|NA	F	Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the stringent response , an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities
b3780	198214.SF3853	9.7e-244	849.0	Gammaproteobacteria													Escherichia	1MU49@1224,1RMWA@1236,COG0513@1,COG0513@2	NA|NA|NA	JKL	DEAD-box RNA helicase involved in
b3781	1080067.BAZH01000037_gene1962	7.9e-57	226.1	Citrobacter													Escherichia	1MZBB@1224,1S5WR@1236,3WYGA@544,COG3118@1,COG3118@2	NA|NA|NA	O	Thioredoxin
b3782	198214.SF3855	2.4e-09	66.6	Gammaproteobacteria													Escherichia	1P6NW@1224,1SW59@1236,2DDEE@1,2ZHQE@2	NA|NA|NA		
b3783	1440052.EAKF1_ch2156c	2.4e-234	817.8	Escherichia	rho	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K03628	ko03018,map03018				ko00000,ko00001,ko03019,ko03021				Escherichia	1MUCF@1224,1RP95@1236,3XPGE@561,COG1158@1,COG1158@2	NA|NA|NA	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
b3784	198214.SF3858	2.7e-189	667.9	Gammaproteobacteria													Escherichia	1MWYW@1224,1RNAP@1236,COG0472@1,COG0472@2	NA|NA|NA	M	Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55)
b3785	155864.EDL933_5105	7.3e-197	693.0	Escherichia	wzzE	GO:0000271,GO:0003674,GO:0005488,GO:0005515,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046378,GO:0071704,GO:1901135,GO:1901137,GO:1901576		ko:K05790					ko00000			iAF1260.b3785,iB21_1397.B21_03612,iBWG_1329.BWG_3467,iECBD_1354.ECBD_4254,iECB_1328.ECB_03663,iECDH10B_1368.ECDH10B_3974,iECDH1ME8569_1439.ECDH1ME8569_3667,iECD_1391.ECD_03663,iECH74115_1262.ECH74115_5218,iECIAI1_1343.ECIAI1_3972,iECSP_1301.ECSP_4833,iECUMN_1333.ECUMN_4310,iETEC_1333.ETEC_4067,iEcDH1_1363.EcDH1_4191,iEcE24377_1341.EcE24377A_4296,iEcHS_1320.EcHS_A4002,iJO1366.b3785,iSF_1195.SF3859,iS_1188.S3901,iSbBS512_1146.SbBS512_E4136,iUMNK88_1353.UMNK88_4594,iY75_1357.Y75_RS18155	Escherichia	1MW70@1224,1RRBS@1236,3XNGX@561,COG3765@1,COG3765@2	NA|NA|NA	M	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
b3786	316407.85676262	6.9e-217	759.6	Escherichia	wecB	GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008761,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046378,GO:0071704,GO:1901135,GO:1901137,GO:1901576	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005			iECOK1_1307.ECOK1_4232,iECS88_1305.ECS88_4208,iECs_1301.ECs4719,iEcSMS35_1347.EcSMS35_4150,iG2583_1286.G2583_4580,iSDY_1059.SDY_3962,iSSON_1240.SSON_3958,iUMN146_1321.UM146_19070,iZ_1308.Z5297	Escherichia	1MWZN@1224,1RPNC@1236,3XM4Q@561,COG0381@1,COG0381@2	NA|NA|NA	M	Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues
b3787	155864.EDL933_5107	8.2e-243	845.9	Escherichia	wecC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046378,GO:0055114,GO:0071704,GO:0089714,GO:1901135,GO:1901137,GO:1901576	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111		R03317	RC00291	ko00000,ko00001,ko01000			iECSE_1348.ECSE_4070	Escherichia	1MUC6@1224,1RMX0@1236,3XNEF@561,COG0677@1,COG0677@2	NA|NA|NA	M	Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD( ) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA)
b3788	316407.85676260	4.5e-210	736.9	Escherichia	rffG	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008460,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_3926,iECSF_1327.ECSF_3628	Escherichia	1MU5E@1224,1RP7G@1236,3XM8Z@561,COG1088@1,COG1088@2	NA|NA|NA	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily
b3789	198214.SF3863	7.1e-169	599.7	Gammaproteobacteria													Escherichia	1MU0X@1224,1RMTR@1236,COG1209@1,COG1209@2	NA|NA|NA	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
b3790	481805.EcolC_4213	4.7e-120	437.2	Escherichia	rffC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044464,GO:0046378,GO:0071704,GO:1901135,GO:1901137,GO:1901576	2.3.1.210	ko:K16704					ko00000,ko01000			iAF1260.b3790,iBWG_1329.BWG_3472,iECBD_1354.ECBD_4249,iECDH10B_1368.ECDH10B_3979,iECDH1ME8569_1439.ECDH1ME8569_3672,iECIAI39_1322.ECIAI39_2997,iEcDH1_1363.EcDH1_4186,iEcolC_1368.EcolC_4213,iJO1366.b3790,iJR904.b3790,iSFV_1184.SFV_3714,iY75_1357.Y75_RS18130	Escherichia	1PHCJ@1224,1RYNF@1236,3XNBF@561,COG0454@1,COG0456@2	NA|NA|NA	K	Catalyzes the acetylation of dTDP-fucosamine (dTDP-4- amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA)
b3791	316407.85676257	1.2e-205	722.2	Escherichia	wecE	GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0005976,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016740,GO:0016769,GO:0019180,GO:0019842,GO:0030170,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046378,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901576	2.6.1.59	ko:K02805					ko00000,ko01000,ko01007			iE2348C_1286.E2348C_4092,iEC55989_1330.EC55989_4263,iECIAI1_1343.ECIAI1_3978,iECIAI39_1322.ECIAI39_2996,iECO103_1326.ECO103_4373,iECO111_1330.ECO111_4617,iECO26_1355.ECO26_4795,iECUMN_1333.ECUMN_4316,iECW_1372.ECW_m4089,iEKO11_1354.EKO11_4565,iSSON_1240.SSON_3963,iWFL_1372.ECW_m4089	Escherichia	1MUPN@1224,1RNEQ@1236,3XMFI@561,COG0399@1,COG0399@2	NA|NA|NA	E	Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate
b3792	198214.SF3866	5.4e-223	780.0	Gammaproteobacteria													Escherichia	1MV5E@1224,1RP0A@1236,COG2244@1,COG2244@2	NA|NA|NA	U	Mediates the transbilayer movement of Und-PP-GlcNAc- ManNAcA-Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA)
b4481	316407.85676255	6.6e-209	733.0	Escherichia	wecF	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008417,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0036065,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046378,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901576	2.4.1.325	ko:K12582			R10303	RC00005,RC00049	ko00000,ko01000,ko01003		GT56	iETEC_1333.ETEC_4075,iSFV_1184.SFV_3711,iSF_1195.SF3867,iSFxv_1172.SFxv_4213,iS_1188.S3893	Escherichia	1PBI5@1224,1RQBD@1236,3XM5B@561,COG0554@1,COG0554@2	NA|NA|NA	C	Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis
b3793	316407.85676254	2.3e-251	874.4	Escherichia	wzyE	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046378,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576		ko:K02853					ko00000,ko01000,ko01003				Escherichia	1MVRX@1224,1RR2C@1236,2DB7H@1,2Z7MA@2,3XPD5@561	NA|NA|NA	S	Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units
b3794	316407.85676253	1.7e-139	501.9	Escherichia	rffM	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046378,GO:0071704,GO:1901135,GO:1901137,GO:1901576	2.4.1.180	ko:K02852					ko00000,ko01000,ko01003		GT26	iLF82_1304.LF82_1862	Escherichia	1N1HD@1224,1RP6P@1236,3XMEI@561,COG1922@1,COG1922@2	NA|NA|NA	M	Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis
b3795	155864.EDL933_5116	6.4e-257	892.9	Escherichia	yifK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03293					ko00000	2.A.3.1			Escherichia	1MUPS@1224,1RR4H@1236,3XNRA@561,COG1113@1,COG1113@2	NA|NA|NA	E	transport protein
b3800	316407.85676251	3.8e-253	880.2	Escherichia	aslB	GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:1901564		ko:K06871					ko00000				Escherichia	1MX3M@1224,1RN4R@1236,3XPDR@561,COG0641@1,COG0641@2	NA|NA|NA	C	protein maturation
b3801	316407.85676250	0.0	1134.0	Escherichia	aslA		3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600		R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000				Escherichia	1MUJH@1224,1RN2V@1236,3XPCB@561,COG3119@1,COG3119@2	NA|NA|NA	P	arylsulfatase activity
b3802	155864.EDL933_5120	6.4e-221	773.1	Escherichia	hemY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K02498					ko00000				Escherichia	1MU7A@1224,1RMRG@1236,3XN16@561,COG3071@1,COG3071@2	NA|NA|NA	H	Involved in a late step of protoheme IX synthesis
b3803	199310.c4722	1.5e-153	549.3	Escherichia	hemX		2.1.1.107	ko:K02496	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000			iAF1260.b3803,iBWG_1329.BWG_3482,iECDH1ME8569_1439.ECDH1ME8569_3682,iECs_1301.ECs4733,iEcDH1_1363.EcDH1_4176,iJO1366.b3803,iJR904.b3803,iUMN146_1321.UM146_19140,iY75_1357.Y75_RS18060,iZ_1308.Z5317	Escherichia	1MY3A@1224,1RNJY@1236,3XMMF@561,COG2959@1,COG2959@2	NA|NA|NA	H	HemX, putative uroporphyrinogen-III C-methyltransferase
b3804	316407.85676247	2.4e-138	498.0	Escherichia	hemD	GO:0003674,GO:0003824,GO:0004852,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000			iSBO_1134.SBO_3815	Escherichia	1MWZD@1224,1RM9K@1236,3XNU7@561,COG1587@1,COG1587@2	NA|NA|NA	H	synthase
b3805	316407.85676246	1.3e-173	615.5	Escherichia	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554	Escherichia	1MU56@1224,1RMQ8@1236,3XMHW@561,COG0181@1,COG0181@2	NA|NA|NA	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
b3806	316407.85676245	0.0	1747.6	Escherichia	cyaA	GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.1	ko:K05851	ko00230,ko02026,ko05111,map00230,map02026,map05111		R00089,R00434	RC00295	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_2672,iECOK1_1307.ECOK1_4253,iECS88_1305.ECS88_4229,iUMN146_1321.UM146_19155,iUTI89_1310.UTI89_C4365	Escherichia	1PI5T@1224,1RMPZ@1236,3XMBV@561,COG3072@1,COG3072@2	NA|NA|NA	F	Belongs to the adenylyl cyclase class-1 family
b3807	316407.85676244	3.1e-58	230.7	Escherichia	cyaY	GO:0003674,GO:0003824,GO:0004322,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008199,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0016530,GO:0016722,GO:0016724,GO:0018282,GO:0018283,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0033554,GO:0034599,GO:0034986,GO:0036211,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0050896,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071704,GO:0071840,GO:0098771,GO:0140104,GO:1901564		ko:K06202					ko00000			iECW_1372.ECW_m4108,iEKO11_1354.EKO11_4552,iWFL_1372.ECW_m4108	Escherichia	1RH9A@1224,1S5UP@1236,3XPP1@561,COG1965@1,COG1965@2	NA|NA|NA	P	Belongs to the frataxin family
b3808	1028307.EAE_07880	2.8e-18	98.6	Gammaproteobacteria													Escherichia	1NG24@1224,1SDK0@1236,2EB6R@1,3357E@2	NA|NA|NA		
b4558	155864.EDL933_5127	1.3e-30	138.3	Escherichia	yifL												Escherichia	1N70H@1224,1SDC8@1236,3XPYT@561,COG5567@1,COG5567@2	NA|NA|NA	N	Prokaryotic lipoprotein-attachment site
b3809	155864.EDL933_5128	3.1e-158	564.3	Escherichia	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_4494	Escherichia	1MWDH@1224,1RMGV@1236,3XP2D@561,COG0253@1,COG0253@2	NA|NA|NA	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
b3810	316407.85676240	4.4e-129	467.2	Escherichia	yigA			ko:K09921					ko00000				Escherichia	1R4BP@1224,1S9SC@1236,3XNG2@561,COG3159@1,COG3159@2	NA|NA|NA	S	Protein of unknown function, DUF484
b3811	199310.c4732	7.2e-169	599.7	Escherichia	xerC	GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363		ko:K03733					ko00000,ko03036				Escherichia	1MUJJ@1224,1RMJG@1236,3XNM4@561,COG4973@1,COG4973@2	NA|NA|NA	D	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids
b3812	198214.SF3890	3.2e-135	487.6	Gammaproteobacteria													Escherichia	1N0I6@1224,1RQ41@1236,COG1011@1,COG1011@2	NA|NA|NA	S	Hydrolase
b3813	316407.85676237	0.0	1440.6	Escherichia	uvrD	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430				ko00000,ko00001,ko01000,ko03400				Escherichia	1MU0G@1224,1RNJI@1236,3XPBA@561,COG0210@1,COG0210@2	NA|NA|NA	L	A helicase with DNA-dependent ATPase activity. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more efficiently from a nicked substrate than ds duplex DNA. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair, and probably also in repair of alkylated DNA
b4482	316407.85676236	1.3e-142	512.3	Escherichia	yigE												Escherichia	1NH9S@1224,1RNWS@1236,3XNYD@561,COG3698@1,COG3698@2	NA|NA|NA	S	Phosphodiester glycosidase
b3816	155864.EDL933_5136	1.2e-174	619.0	Escherichia	corA	GO:0000041,GO:0003674,GO:0005215,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0015075,GO:0015087,GO:0015095,GO:0015099,GO:0015318,GO:0015675,GO:0015693,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035444,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830		ko:K03284					ko00000,ko02000	1.A.35.1,1.A.35.3			Escherichia	1MWMP@1224,1RNDQ@1236,3XN9J@561,COG0598@1,COG0598@2	NA|NA|NA	P	Mediates influx of magnesium ions
b3817	316407.85676234	7e-65	253.1	Escherichia	yigF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RK5D@1224,1S717@1236,2AMA3@1,31C50@2,3XPYM@561	NA|NA|NA	S	Protein of unknown function (DUF2628)
b3818	316407.85676233	1.6e-61	241.9	Escherichia	yigG	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944											Escherichia	1N6C0@1224,1S9CI@1236,2C2M1@1,32XE7@2,3XRE1@561	NA|NA|NA		
b3819	316407.85676232	3.2e-161	574.3	Escherichia	rarD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944		ko:K05786					ko00000,ko02000	2.A.7.7			Escherichia	1MX5G@1224,1RMAC@1236,3XP4W@561,COG2962@1,COG2962@2	NA|NA|NA	S	EamA-like transporter family
b3820	155864.EDL933_5142	1.2e-79	302.4	Escherichia	yigI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N5HF@1224,1RNAK@1236,3XPAZ@561,COG2050@1,COG2050@2	NA|NA|NA	Q	Thioesterase superfamily
b3821	155864.EDL933_5143	5.2e-172	610.1	Escherichia	pldA	GO:0003674,GO:0003824,GO:0004620,GO:0004623,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005623,GO:0008970,GO:0009279,GO:0016020,GO:0016021,GO:0016298,GO:0016787,GO:0016788,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0046872,GO:0046983,GO:0052689,GO:0071944	3.1.1.32,3.1.1.4	ko:K01058	ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110		R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko01000			iEC042_1314.EC042_4201,iECUMN_1333.ECUMN_4347,iEcSMS35_1347.EcSMS35_4188	Escherichia	1PC8I@1224,1RMJH@1236,3XM7B@561,COG2829@1,COG2829@2	NA|NA|NA	M	hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities
b3822	155864.EDL933_5144	0.0	1221.5	Escherichia	recQ	GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949	3.6.4.12	ko:K03654	ko03018,map03018				ko00000,ko00001,ko01000,ko03400				Escherichia	1MVGG@1224,1RMPG@1236,3XNKI@561,COG0514@1,COG0514@2	NA|NA|NA	L	ATP-dependent DNA helicase
b3823	316407.85676228	3.4e-109	401.0	Escherichia	rhtC	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0042968,GO:0042970,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K05835					ko00000,ko02000	2.A.76.1.2			Escherichia	1MX0K@1224,1RP43@1236,3XP86@561,COG1280@1,COG1280@2	NA|NA|NA	E	Threonine efflux protein
b3824	155864.EDL933_5146	2.3e-105	388.3	Escherichia	rhtB	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0042968,GO:0042970,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K05834					ko00000,ko02000	2.A.76.1.1		iECIAI39_1322.ECIAI39_3185	Escherichia	1MXAI@1224,1RPWN@1236,3XNZJ@561,COG1280@1,COG1280@2	NA|NA|NA	E	Conducts the efflux of homoserine and homoserine lactone
b3825	199310.c4747	1.6e-204	718.4	Escherichia	pldB	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016298,GO:0016740,GO:0016746,GO:0016747,GO:0016787,GO:0016788,GO:0044238,GO:0044464,GO:0052689,GO:0071704,GO:0071944	3.1.1.5	ko:K01048	ko00564,map00564				ko00000,ko00001,ko01000			iETEC_1333.ETEC_4102,iEcHS_1320.EcHS_A4049	Escherichia	1MWDA@1224,1RRJP@1236,3XMJA@561,COG2267@1,COG2267@2	NA|NA|NA	I	Lysophospholipase L2
b3826	316407.85676225	1.3e-153	548.9	Escherichia	yigL	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033883,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050308										iUTI89_1310.UTI89_C4390	Escherichia	1MV02@1224,1RP1D@1236,3XMVF@561,COG0561@1,COG0561@2	NA|NA|NA	S	Catalyzes Strongly the dephosphorylation of pyridoxal- phosphate (PLP) and moderately the dephosphorylation of 2- deoxyglucose 6-phosphate (2bGLU6P) and beta-glucose 6-phosphate (bGlu6P). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates
b3827	199310.c4749	5.2e-167	593.6	Escherichia	yigM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MWMC@1224,1RQST@1236,3XP2T@561,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
b3828	155864.EDL933_5150	1.5e-180	638.6	Escherichia	metR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016597,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K03576					ko00000,ko03000				Escherichia	1MUIX@1224,1RRF3@1236,3XPAG@561,COG0583@1,COG0583@2	NA|NA|NA	K	MetR is a positive activator of the metA, metE and metH genes
b3829	316407.85676222	0.0	1544.3	Escherichia	metE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0032259,GO:0034641,GO:0035999,GO:0036211,GO:0042084,GO:0042085,GO:0042558,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0050667,GO:0051186,GO:0071704,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_4130,iECO103_1326.ECO103_4334,iECO111_1330.ECO111_4657,iECO26_1355.ECO26_4756,iECW_1372.ECW_m4131,iEKO11_1354.EKO11_4528,iWFL_1372.ECW_m4131	Escherichia	1MUI9@1224,1RMBA@1236,3XP3E@561,COG0620@1,COG0620@2	NA|NA|NA	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
b3830	316407.85676221	2.2e-156	558.1	Escherichia	ysgA		3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130		R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000				Escherichia	1MW7S@1224,1RPGK@1236,3XM95@561,COG0412@1,COG0412@2	NA|NA|NA	Q	carboxymethylenebutenolidase activity
b3831	316407.85676220	9.6e-138	496.1	Escherichia	udp	GO:0003674,GO:0003824,GO:0004850,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006218,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016043,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0022607,GO:0030955,GO:0031420,GO:0033554,GO:0034214,GO:0034641,GO:0034655,GO:0034656,GO:0042454,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046108,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0050896,GO:0051259,GO:0051716,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100		R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_2630,iB21_1397.B21_03667,iECABU_c1320.ECABU_c43290,iECBD_1354.ECBD_4198,iECB_1328.ECB_03718,iECD_1391.ECD_03718,iECNA114_1301.ECNA114_4136,iECOK1_1307.ECOK1_4296,iECP_1309.ECP_4040,iECS88_1305.ECS88_4275,iECSF_1327.ECSF_3683,iEcSMS35_1347.EcSMS35_4208,iLF82_1304.LF82_2357,iNRG857_1313.NRG857_19105,iUMN146_1321.UM146_19385,iUMNK88_1353.UMNK88_4655	Escherichia	1P0EC@1224,1RN3N@1236,3XN82@561,COG2820@1,COG2820@2	NA|NA|NA	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
b3832	155864.EDL933_5154	8.6e-257	892.5	Escherichia	rmuC	GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360		ko:K09760					ko00000				Escherichia	1MWHV@1224,1RMB8@1236,3XMJN@561,COG1322@1,COG1322@2	NA|NA|NA	S	DNA recombination protein RmuC
b3833	1440052.EAKF1_ch2109c	1.2e-140	505.8	Escherichia	ubiE	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000			iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355	Escherichia	1MX8I@1224,1RMAU@1236,3XNXR@561,COG0500@1,COG2226@2	NA|NA|NA	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
b3834	198214.SF3912	2.9e-105	387.9	Gammaproteobacteria													Escherichia	1R1CM@1224,1S745@1236,COG3165@1,COG3165@2	NA|NA|NA	S	protein conserved in bacteria
b3835	155864.EDL933_5157	0.0	1115.5	Escherichia	ubiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663		ko:K03688					ko00000				Escherichia	1MU1Z@1224,1RNQM@1236,3XNRF@561,COG0661@1,COG0661@2	NA|NA|NA	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
b3836	155864.EDL933_5158	2e-37	161.4	Escherichia	tatA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680		ko:K03116	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Escherichia	1N6S4@1224,1SCC7@1236,3XPXZ@561,COG1826@1,COG1826@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
b3838	155864.EDL933_5159	1.2e-70	272.7	Escherichia	tatB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680		ko:K03117	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Escherichia	1N73F@1224,1SD9K@1236,3XP1U@561,COG1826@1,COG1826@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
b3839	155864.EDL933_5160	1.7e-126	458.8	Escherichia	tatC	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680		ko:K03118	ko03060,ko03070,map03060,map03070	M00336			ko00000,ko00001,ko00002,ko02044	2.A.64			Escherichia	1MVAY@1224,1RPRN@1236,3XPGT@561,COG0805@1,COG0805@2	NA|NA|NA	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
b4483	316407.85676212	4.5e-151	540.4	Escherichia	tatD	GO:0000175,GO:0000302,GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009056,GO:0009057,GO:0009636,GO:0009987,GO:0010035,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046700,GO:0046872,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901700		ko:K03424					ko00000,ko01000				Escherichia	1MXN8@1224,1RNCC@1236,3XP9Y@561,COG0084@1,COG0084@2	NA|NA|NA	L	3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair
b3842	155864.EDL933_5162	1.7e-87	328.6	Escherichia	rfaH	GO:0001000,GO:0001073,GO:0001121,GO:0001124,GO:0003674,GO:0003676,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008494,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032270,GO:0032774,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045182,GO:0045727,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090079,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K05785					ko00000,ko03000				Escherichia	1N01W@1224,1S91B@1236,3XM7J@561,COG0250@1,COG0250@2	NA|NA|NA	K	Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho- dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains
b3843	199310.c4790	5e-300	1036.2	Escherichia	ubiD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000			iECO111_1330.ECO111_4669	Escherichia	1MU62@1224,1RNH8@1236,3XMYJ@561,COG0043@1,COG0043@2	NA|NA|NA	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis
b3844	155864.EDL933_5164	2.1e-131	474.9	Escherichia	fre	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0006950,GO:0006979,GO:0008047,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0019538,GO:0030091,GO:0030234,GO:0042602,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0050896,GO:0052875,GO:0055114,GO:0065007,GO:0065009,GO:0071704,GO:0098772,GO:1901564	1.16.1.3,1.5.1.41	ko:K05368	ko00740,ko00860,ko01100,map00740,map00860,map01100		R00097,R05705	RC00126,RC00220	ko00000,ko00001,ko01000			iSF_1195.SF3920,iSFxv_1172.SFxv_4273,iS_1188.S3832	Escherichia	1MV72@1224,1RPH5@1236,3XPH0@561,COG0543@1,COG0543@2	NA|NA|NA	C	Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduce the complexed Fe(3 ) iron of siderophores to Fe(2 ), thus releasing it from the chelator
b3845	316407.85676208	7.1e-217	759.6	Escherichia	fadA	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000			iECP_1309.ECP_4058,iEcE24377_1341.EcE24377A_4364	Escherichia	1MU5G@1224,1RM93@1236,3XM40@561,COG0183@1,COG0183@2	NA|NA|NA	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed
b3846	316407.85676207	0.0	1449.1	Escherichia	fadB	GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000			iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200	Escherichia	1MU9P@1224,1RMZ8@1236,3XMBN@561,COG1024@1,COG1024@2,COG1250@1,COG1250@2	NA|NA|NA	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate
b3847	316407.85676206	6.1e-265	919.5	Escherichia	pepQ	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.13.9	ko:K01271					ko00000,ko01000,ko01002				Escherichia	1MURT@1224,1RMKT@1236,3XM9C@561,COG0006@1,COG0006@2	NA|NA|NA	E	Splits dipeptides with a prolyl residue in the C- terminal position
b3848	316407.85676205	5.8e-109	400.2	Escherichia	yigZ												Escherichia	1NFJC@1224,1RPBF@1236,3XNVA@561,COG1739@1,COG1739@2	NA|NA|NA	S	Uncharacterized protein family UPF0029
b3849	155864.EDL933_5169	4.3e-272	943.3	Escherichia	trkH	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662		ko:K03498					ko00000,ko02000	2.A.38.1,2.A.38.4		iSFV_1184.SFV_3651	Escherichia	1MUIJ@1224,1RMN6@1236,3XMVE@561,COG0168@1,COG0168@2	NA|NA|NA	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA
b3850	155864.EDL933_5170	4.3e-100	370.5	Escherichia	hemG	GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000			iAF1260.b3850,iAPECO1_1312.APECO1_2607,iB21_1397.B21_03690,iBWG_1329.BWG_3526,iE2348C_1286.E2348C_4162,iECABU_c1320.ECABU_c43520,iECBD_1354.ECBD_4175,iECB_1328.ECB_03741,iECDH10B_1368.ECDH10B_4039,iECDH1ME8569_1439.ECDH1ME8569_3727,iECD_1391.ECD_03741,iECED1_1282.ECED1_4552,iECH74115_1262.ECH74115_5289,iECIAI1_1343.ECIAI1_4043,iECNA114_1301.ECNA114_4159,iECOK1_1307.ECOK1_4319,iECS88_1305.ECS88_4298,iECSF_1327.ECSF_3707,iECSP_1301.ECSP_4903,iECs_1301.ECs4778,iEcDH1_1363.EcDH1_4131,iEcHS_1320.EcHS_A4073,iEcolC_1368.EcolC_4160,iG2583_1286.G2583_4648,iJO1366.b3850,iJR904.b3850,iLF82_1304.LF82_0981,iNRG857_1313.NRG857_19220,iSDY_1059.SDY_3895,iUMN146_1321.UM146_19505,iUMNK88_1353.UMNK88_4678,iUTI89_1310.UTI89_C4435,iY75_1357.Y75_RS17835,iZ_1308.Z5372,ic_1306.c4797	Escherichia	1RAH2@1224,1S372@1236,3XN1Z@561,COG4635@1,COG4635@2	NA|NA|NA	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX using menaquinone as electron acceptor
b3856	469008.B21_03691	1.3e-93	349.0	Escherichia	mobB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03753					ko00000			iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805	Escherichia	1RD3Q@1224,1S72P@1236,3XNU6@561,COG1763@1,COG1763@2	NA|NA|NA	H	GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity. Is also able to bind the nucleotides ATP, TTP and GDP, but with lower affinity than GTP
b3857	316407.85676201	1.1e-109	402.5	Escherichia	mobA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061603,GO:0070568,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902757,GO:1902758	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100		R11581		ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_2604,iEcHS_1320.EcHS_A4080,iEcolC_1368.EcolC_4158,iLF82_1304.LF82_1370,iNRG857_1313.NRG857_19230,iSBO_1134.SBO_3869,iSbBS512_1146.SbBS512_E4329,iUMNK88_1353.UMNK88_4686,ic_1306.c4801	Escherichia	1RH3M@1224,1S74N@1236,3XPN6@561,COG0746@1,COG0746@2	NA|NA|NA	F	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
b3858	1440052.EAKF1_ch2090c	5.3e-43	179.9	Escherichia	yihD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09896					ko00000				Escherichia	1N026@1224,1S93G@1236,3XPVB@561,COG3084@1,COG3084@2	NA|NA|NA	S	Protein of unknown function (DUF1040)
b3859	316407.85676199	7.1e-194	682.9	Escherichia	srkA	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564											Escherichia	1MU2Q@1224,1RNHI@1236,3XNBG@561,COG2334@1,COG2334@2	NA|NA|NA	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
b3860	155864.EDL933_5175	1.6e-114	418.7	Escherichia	dsbA	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071236,GO:0140096		ko:K03673	ko01503,map01503	M00728			ko00000,ko00001,ko00002,ko03110			iEcSMS35_1347.EcSMS35_4241	Escherichia	1RGWH@1224,1S5WA@1236,3XNYE@561,COG1651@1,COG1651@2	NA|NA|NA	O	Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB
b3861	316407.85676197	1.7e-268	931.4	Escherichia	yihF												Escherichia	1MYKE@1224,1RRAU@1236,3XMTN@561,COG5339@1,COG5339@2	NA|NA|NA	S	Bacterial protein of unknown function (DUF945)
b3862	316407.85676196	5.2e-170	603.6	Escherichia	yihG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MVWG@1224,1RR21@1236,3XMIX@561,COG0204@1,COG0204@2	NA|NA|NA	I	transferase activity, transferring acyl groups
b3863	316407.85676195	0.0	1820.4	Escherichia	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440		R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400				Escherichia	1MU31@1224,1RNBG@1236,3XNHM@561,COG0258@1,COG0258@2,COG0749@1,COG0749@2	NA|NA|NA	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
b3865	1440052.EAKF1_ch2082	2.8e-111	407.9	Escherichia	engB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K03978					ko00000,ko03036				Escherichia	1MY3Z@1224,1RNJP@1236,3XN28@561,COG0218@1,COG0218@2	NA|NA|NA	D	Necessary for normal cell division and for the maintenance of normal septation
b3866	198214.SF3936	2.8e-53	214.9	Gammaproteobacteria													Escherichia	1N8HM@1224,1SDUG@1236,COG3078@1,COG3078@2	NA|NA|NA	S	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis
b3867	155864.EDL933_5186	7.7e-271	939.1	Escherichia	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.98.3	ko:K02495	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R06895	RC00884	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403	Escherichia	1MV1I@1224,1RN1Y@1236,3XMD9@561,COG0635@1,COG0635@2	NA|NA|NA	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family
b4686	362663.ECP_4078	9.1e-10	68.2	Gammaproteobacteria													Escherichia	1P8DX@1224,1SVWN@1236,2C785@1,2ZG52@2	NA|NA|NA		
b3868	155864.EDL933_5187	8.2e-268	929.1	Escherichia	glnG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K07712	ko02020,map02020	M00497			ko00000,ko00001,ko00002,ko02022				Escherichia	1MU0N@1224,1RMCK@1236,3XNAJ@561,COG2204@1,COG2204@2	NA|NA|NA	T	Member of the two-component regulatory system NtrB NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter- sigma54-RNA polymerase complexes
b3869	155864.EDL933_5188	2.4e-195	688.0	Escherichia	glnL	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564	2.7.13.3	ko:K07708	ko02020,map02020	M00497			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1MVN6@1224,1RN15@1236,3XNNN@561,COG3852@1,COG3852@2	NA|NA|NA	F	Member of the two-component regulatory system NtrB NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Under conditions of nitrogen limitation, NtrB autophosphorylates and transfers the phosphoryl group to NtrC. In the presence of nitrogen, acts as a phosphatase that dephosphorylates and inactivates NtrC
b3870	155864.EDL933_5189	4.1e-275	953.4	Escherichia	glnA	GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009314,GO:0009628,GO:0009987,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019676,GO:0019740,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:1901564,GO:1901605	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727		R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147				Escherichia	1MUGQ@1224,1RMD1@1236,3XMQ8@561,COG0174@1,COG0174@2	NA|NA|NA	F	Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia
b3871	155864.EDL933_5190	0.0	1203.0	Escherichia	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840		ko:K06207					ko00000				Escherichia	1MV5Q@1224,1RMJB@1236,3XNMS@561,COG1217@1,COG1217@2	NA|NA|NA	T	Probably interacts with the ribosomes in a GTP dependent manner
b3872	155864.EDL933_5191	2.7e-134	484.6	Escherichia	yihL	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1R4PN@1224,1RQ87@1236,3XQCK@561,COG2188@1,COG2188@2	NA|NA|NA	K	HTH-type transcriptional regulator YihL
b3873	316407.85676186	7.4e-183	646.4	Escherichia	yihM												Escherichia	1MY5W@1224,1RW4G@1236,3XQ67@561,COG1082@1,COG1082@2	NA|NA|NA	G	Xylose isomerase-like TIM barrel
b3874	316407.85676185	1.3e-235	822.0	Escherichia	yihN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MXUC@1224,1RRF8@1236,3XQBM@561,COG2271@1,COG2271@2	NA|NA|NA	P	transmembrane transport
b3875	316407.85676184	2.4e-135	488.0	Gammaproteobacteria													Escherichia	1R4ZS@1224,1RQHC@1236,COG1452@1,COG1452@2	NA|NA|NA	M	Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is
b3876	316407.85676183	5.3e-267	926.4	Gammaproteobacteria													Escherichia	1QPAN@1224,1S0SW@1236,COG2211@1,COG2211@2	NA|NA|NA	G	transporter
b3877	316407.85676182	6.4e-265	919.5	Gammaproteobacteria													Escherichia	1MXNE@1224,1RQDE@1236,COG2211@1,COG2211@2	NA|NA|NA	G	transporter
b3878	316407.85676181	0.0	1456.8	Escherichia	yihQ	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016787,GO:0016798,GO:0019637,GO:0034308,GO:0042180,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777,GO:1990929	3.2.1.199	ko:K15922			R00802,R11543	RC00028,RC00059,RC00077,RC00451	ko00000,ko01000		GH31		Escherichia	1MWNJ@1224,1RMJ9@1236,3XMXR@561,COG1501@1,COG1501@2	NA|NA|NA	G	Belongs to the glycosyl hydrolase 31 family
b3879	316407.85676180	1.9e-180	638.3	Gammaproteobacteria													Escherichia	1NC16@1224,1RPKG@1236,COG2017@1,COG2017@2	NA|NA|NA	G	aldose 1-epimerase activity
b3880	316407.85676179	1.8e-247	861.3	Escherichia	yihS	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016853,GO:0016860,GO:0016861,GO:0019637,GO:0034308,GO:0042180,GO:0042802,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0050089,GO:0061593,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777	5.3.1.31	ko:K18479			R10765	RC00376	ko00000,ko01000				Escherichia	1MX1J@1224,1RSCF@1236,3XQXT@561,COG2942@1,COG2942@2	NA|NA|NA	G	Catalyzes the isomerization of sulfoquinovose (SQ) to 6- deoxy-6-sulfo-D-fructose (SF)
b3881	316407.85676178	2.9e-162	577.8	Escherichia	yihT	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0034308,GO:0042180,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0061595,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777	4.1.2.57	ko:K01671			R10760	RC00438,RC00439	ko00000,ko01000				Escherichia	1QZI3@1224,1RYP6@1236,3XP8T@561,COG3684@1,COG3684@2	NA|NA|NA	G	Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA)
b3882	198214.SF3954	2.5e-161	574.7	Gammaproteobacteria													Escherichia	1RA7F@1224,1RMMY@1236,COG2084@1,COG2084@2	NA|NA|NA	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family
b3883	316407.85676176	4e-167	594.0	Escherichia	yihV	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0034308,GO:0042180,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0061594,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777	2.7.1.184	ko:K18478			R10970	RC00002,RC00017	ko00000,ko01000				Escherichia	1MWX4@1224,1RQW6@1236,3XPC4@561,COG0524@1,COG0524@2	NA|NA|NA	F	Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6- deoxy-6-sulfo-D-fructose 1-phosphate (SFP)
b3884	155864.EDL933_5204	4e-139	500.7	Escherichia	yihW	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1MUJG@1224,1RQW5@1236,3XP99@561,COG1349@1,COG1349@2	NA|NA|NA	K	transcriptional regulator
b3885	198214.SF3957	5.4e-112	410.2	Gammaproteobacteria													Escherichia	1PGNF@1224,1RRDC@1236,COG1011@1,COG1011@2	NA|NA|NA	S	hydrolase
b3886	155864.EDL933_5206	4.6e-144	517.3	Escherichia	yihY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K07058					ko00000				Escherichia	1QICW@1224,1RMKI@1236,3XN3U@561,COG1295@1,COG1295@2	NA|NA|NA	S	UPF0761 membrane protein YihY
b3887	155864.EDL933_5207	8.6e-75	286.2	Escherichia	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360		ko:K07560					ko00000,ko01000,ko03016				Escherichia	1RGTV@1224,1S61I@1236,3XNWE@561,COG1490@1,COG1490@2	NA|NA|NA	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality
b3888	155864.EDL933_5208	2.5e-191	674.5	Escherichia	yiiD	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564											Escherichia	1R407@1224,1RPJ2@1236,3XP34@561,COG0454@1,COG0456@2	NA|NA|NA	K	protein acetylation
b3889	155864.EDL933_5212	4.5e-32	143.3	Escherichia	yiiE												Escherichia	1QIPE@1224,1TGIQ@1236,3XR5Q@561,COG3905@1,COG3905@2	NA|NA|NA	K	regulation of nucleic acid-templated transcription
b3890	198214.SF3966	3.1e-33	147.1	Gammaproteobacteria													Escherichia	1NJ8V@1224,1SH2N@1236,COG3905@1,COG3905@2	NA|NA|NA	K	Ribbon-helix-helix protein, copG family
b3891	316407.85676168	1.3e-176	625.5	Escherichia	fdhE	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008150,GO:0008152,GO:0008199,GO:0010467,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:1901564		ko:K02380					ko00000				Escherichia	1NK06@1224,1RQC4@1236,3XMIZ@561,COG3058@1,COG3058@2	NA|NA|NA	O	Necessary for formate dehydrogenase activity
b3892	155864.EDL933_5216	3.8e-116	424.1	Escherichia	fdoI	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0032991,GO:0033554,GO:0036397,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0050896,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:0071944,GO:1902494		ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200		R00519	RC02796	ko00000,ko00001				Escherichia	1MXFQ@1224,1RNHH@1236,3XP33@561,COG2864@1,COG2864@2	NA|NA|NA	C	Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase
b3893	198214.SF3969	3.7e-181	640.6	Gammaproteobacteria													Escherichia	1MU1B@1224,1RNFG@1236,COG0437@1,COG0437@2	NA|NA|NA	C	formate dehydrogenase
b3894	316407.85676165	0.0	2113.2	Escherichia	fdoG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008430,GO:0009055,GO:0009061,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030151,GO:0030288,GO:0030313,GO:0031975,GO:0032787,GO:0032991,GO:0033554,GO:0036397,GO:0042597,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:1902494	1.17.1.9,1.17.5.3	ko:K00123,ko:K08348	ko00630,ko00680,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map01100,map01120,map01200,map02020		R00519	RC02796	ko00000,ko00001,ko01000	5.A.3.2		iECW_1372.ECW_m4203,iECs_1301.ECs2078,iWFL_1372.ECW_m4203,iZ_1308.Z2236	Escherichia	1MW3N@1224,1RN6N@1236,3XM6Z@561,COG0243@1,COG0243@2,COG3383@1,COG3383@2	NA|NA|NA	C	Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar)
b3895	316407.85676164	1.7e-156	558.5	Escherichia	fdhD	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0043085,GO:0043546,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0050790,GO:0065007,GO:0065009,GO:0097159,GO:0097163,GO:0140104,GO:1901363		ko:K02379					ko00000				Escherichia	1NRU0@1224,1RNFH@1236,3XNWH@561,COG1526@1,COG1526@2	NA|NA|NA	J	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
b3896	316407.85676163	3e-190	671.0	Escherichia	yiiG												Escherichia	1RFF5@1224,1S3Y0@1236,2A2TX@1,30R7T@2,3XPFG@561	NA|NA|NA	S	Protein of unknown function (DUF3829)
b3897	316407.85676162	0.0	1162.9	Gammaproteobacteria													Escherichia	1PIA1@1224,1S0BZ@1236,COG1762@1,COG1762@2,COG3711@1,COG3711@2	NA|NA|NA	GKT	Frv operon regulatory protein
b3898	316407.85676161	2.1e-199	701.4	Escherichia	frvX			ko:K18530					ko00000,ko01000,ko01002				Escherichia	1MXEU@1224,1RYRZ@1236,3XN5P@561,COG1363@1,COG1363@2	NA|NA|NA	G	Has a broad aminopeptidase activity on non-blocked peptides by progressively cleaving amino acids off the peptide substrate. Aminopeptidase activity stops at the residue before the first proline in the peptide. Cannot cleave when proline is the first N-terminal residue
b3899	316407.85676160	5.7e-264	916.4	Escherichia	frvB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563		ko:K11202,ko:K11203		M00306			ko00000,ko00002,ko01000,ko02000	4.A.2.1			Escherichia	1R5GJ@1224,1S19Y@1236,3XRKB@561,COG1299@1,COG1299@2,COG1445@1,COG1445@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrvAB PTS system is involved in fructose transport
b3900	316407.85676159	1.2e-79	302.4	Escherichia	frvA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K11201	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273,M00306	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1			Escherichia	1RBJS@1224,1S2C8@1236,3XRDF@561,COG1762@1,COG1762@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrvAB PTS system is involved in fructose transport
b3901	316407.85676158	2.9e-56	224.2	Escherichia	rhaM	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	5.1.3.32	ko:K03534			R10819	RC00563	ko00000,ko01000				Escherichia	1RGYV@1224,1S6AI@1236,3XPXF@561,COG3254@1,COG3254@2	NA|NA|NA	G	Involved in the anomeric conversion of L-rhamnose
b3902	316407.85676157	3e-161	574.3	Escherichia	rhaD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008994,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0042802,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0071704,GO:1901575	4.1.2.19	ko:K01629	ko00040,ko00051,ko01120,map00040,map00051,map01120		R01785,R02263	RC00438,RC00599,RC00603,RC00604	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_5354,iECSP_1301.ECSP_4963,iECs_1301.ECs4829,iLF82_1304.LF82_1866,iNRG857_1313.NRG857_19475,iSSON_1240.SSON_4072,iZ_1308.Z5446,ic_1306.c4851	Escherichia	1MXV2@1224,1RP50@1236,3XP6R@561,COG0235@1,COG0235@2	NA|NA|NA	G	Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde
b3903	316407.85676156	7.1e-247	859.4	Escherichia	rhaA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008270,GO:0008740,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0022607,GO:0030145,GO:0030246,GO:0032991,GO:0033296,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046872,GO:0046914,GO:0048029,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901575	5.3.1.14	ko:K01813	ko00051,ko01120,map00051,map01120		R02437	RC00434	ko00000,ko00001,ko01000			iECIAI39_1322.ECIAI39_3092,iUMNK88_1353.UMNK88_4739	Escherichia	1MW7Z@1224,1RPDX@1236,3XN9F@561,COG4806@1,COG4806@2	NA|NA|NA	G	L-rhamnose isomerase activity
b3904	316407.85676155	5.7e-288	996.1	Escherichia	rhaB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008993,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120		R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000			iEcE24377_1341.EcE24377A_4435	Escherichia	1N51F@1224,1RQX6@1236,3XPCK@561,COG1070@1,COG1070@2	NA|NA|NA	F	Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate
b3905	316407.85676154	5.7e-160	570.1	Escherichia	rhaS	GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141		ko:K02855					ko00000,ko03000				Escherichia	1Q7DC@1224,1RQ1U@1236,3XMYV@561,COG4977@1,COG4977@2	NA|NA|NA	K	Activates expression of the rhaBAD and rhaT operons
b3906	316407.85676153	5.6e-163	580.1	Escherichia	rhaR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02854					ko00000,ko03000				Escherichia	1QA56@1224,1RSI2@1236,3XP90@561,COG1917@1,COG1917@2,COG4977@1,COG4977@2	NA|NA|NA	K	Activates expression of the rhaSR operon in response to L-rhamnose
b3907	316407.85676152	5.6e-189	666.8	Escherichia	rhaT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0015291,GO:0015293,GO:0015749,GO:0015762,GO:0016020,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K02856					ko00000,ko02000	2.A.7.6		iECSE_1348.ECSE_4196,iEcE24377_1341.EcE24377A_4438	Escherichia	1MXB3@1224,1RQV6@1236,2Z7ID@2,3XPC7@561,COG0697@1	NA|NA|NA	EG	Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system)
b3908	316407.85676151	4.4e-117	427.2	Escherichia	sodA	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004784,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009268,GO:0009408,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010269,GO:0010447,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0030145,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071241,GO:0071248,GO:0071291,GO:0071450,GO:0071451,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016				ko00000,ko00001,ko01000			iE2348C_1286.E2348C_4213,iECSF_1327.ECSF_3769	Escherichia	1MVW2@1224,1RP7X@1236,3XNVZ@561,COG0605@1,COG0605@2	NA|NA|NA	P	radicals which are normally produced within the cells and which are toxic to biological systems
b3909	198214.SF3986	2e-167	595.1	Gammaproteobacteria													Escherichia	1MV01@1224,1RSNP@1236,28H7K@1,2Z7JT@2	NA|NA|NA	U	The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system
b3910	316407.85676149	3.2e-129	467.6	Escherichia	yiiM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0098754											Escherichia	1RAPM@1224,1RRB8@1236,3XMCD@561,COG2258@1,COG2258@2	NA|NA|NA	S	toxin catabolic process
b3911	199310.c4863	3.1e-256	890.6	Escherichia	cpxA	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007155,GO:0007165,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0022610,GO:0023014,GO:0023052,GO:0031224,GO:0031589,GO:0035556,GO:0036211,GO:0042710,GO:0042802,GO:0043170,GO:0043412,GO:0043708,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0044764,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0090605,GO:0140096,GO:1901564	2.7.13.3	ko:K07640	ko01503,ko02020,map01503,map02020	M00447,M00727,M00728			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1MUAK@1224,1RPDY@1236,3XPHK@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
b3912	198214.SF3991	8.2e-128	463.0	Gammaproteobacteria													Escherichia	1MVCB@1224,1RMW7@1236,COG0745@1,COG0745@2	NA|NA|NA	K	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
b4484	155864.EDL933_5242	2e-80	305.1	Escherichia	cpxP	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031975,GO:0042597,GO:0042802,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051082,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K06006					ko00000,ko03110				Escherichia	1RIYB@1224,1S628@1236,3XPJN@561,COG3678@1,COG3678@2	NA|NA|NA	NPTU	overexpression decreases Cpx pathway activity. Some periplasmic stimulii (shown for P pili subunit PapE and probably 0.3 M NaCl) increase CpxP's susceptibility to DegP, leading to CpxP degradation, inducing the Cpx pathway. Aids in combating extracytoplasmic protein- mediated toxicity. Overexpression leads to degradation by DegP of misfolded P pili subunits in the periplasm (tested using PapE). Inhibits autophosphorylation of CpxA in reconstituted liposomes by 50 but has no effect on phosphatase activity of CpxA. Has mild protein chaperone activity
b3915	155864.EDL933_5243	2.3e-162	578.2	Escherichia	fieF	GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005385,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006829,GO:0006873,GO:0006875,GO:0006876,GO:0006882,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015086,GO:0015093,GO:0015291,GO:0015318,GO:0015341,GO:0015562,GO:0015684,GO:0015691,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034755,GO:0042592,GO:0042802,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055069,GO:0055073,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072503,GO:0072507,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1903874		ko:K13283					ko00000,ko02000	2.A.4.7.1			Escherichia	1MUDS@1224,1RNS2@1236,3XN1Q@561,COG0053@1,COG0053@2	NA|NA|NA	P	Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2 ) in a proton- dependent manner
b3916	155864.EDL933_5244	2.5e-183	647.9	Escherichia	pfkA	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003872,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005945,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008443,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019200,GO:0019318,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035639,GO:0036094,GO:0042802,GO:0042866,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0061615,GO:0061695,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494,GO:1990234	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019			iNRG857_1313.NRG857_19550	Escherichia	1MVN3@1224,1RMVY@1236,3XNE3@561,COG0205@1,COG0205@2	NA|NA|NA	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis
b3917	198214.SF3995	9.1e-189	666.0	Gammaproteobacteria													Escherichia	1MUAU@1224,1RMAR@1236,COG1613@1,COG1613@2	NA|NA|NA	P	sulfate ABC transporter
b3918	316407.85676142	3.7e-142	510.8	Escherichia	cdh	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006244,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008715,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009395,GO:0009987,GO:0016020,GO:0016042,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046341,GO:0046342,GO:0046434,GO:0046475,GO:0046483,GO:0046486,GO:0046503,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072529,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.6.1.26	ko:K01521	ko00564,ko01110,map00564,map01110		R01797	RC00002	ko00000,ko00001,ko01000			iE2348C_1286.E2348C_4222,iECABU_c1320.ECABU_c44240,iLF82_1304.LF82_0283,iNRG857_1313.NRG857_19560,iSFxv_1172.SFxv_4357,ic_1306.c4870	Escherichia	1NGNY@1224,1RMYU@1236,3XNN6@561,COG2134@1,COG2134@2	NA|NA|NA	I	CDP-diacylglycerol catabolic process
b3919	155864.EDL933_5248	1.4e-136	492.3	Escherichia	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147				Escherichia	1MWK5@1224,1RM8I@1236,3XMQC@561,COG0149@1,COG0149@2	NA|NA|NA	F	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
b3920	316407.85676140	1.2e-103	382.5	Escherichia	yiiQ												Escherichia	1R3S9@1224,1S0JQ@1236,2CM5I@1,2Z94B@2,3XNRX@561	NA|NA|NA	S	Protein of unknown function (DUF1454)
b3921	155864.EDL933_5250	8.9e-80	302.8	Escherichia	yiiR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RD1M@1224,1S2CI@1236,3XPKT@561,COG3152@1,COG3152@2	NA|NA|NA	S	Protein of unknown function (DUF805)
b3922	316407.85676138	9.8e-46	189.1	Escherichia	yiiS												Escherichia	1NCVJ@1224,1SFQD@1236,3XPU6@561,COG3691@1,COG3691@2	NA|NA|NA	S	Protein of unknown function (DUF406)
b3923	198214.SF4001	2.6e-76	291.2	Gammaproteobacteria													Escherichia	1NR8I@1224,1SMC8@1236,COG0589@1,COG0589@2	NA|NA|NA	T	Required for resistance to DNA-damaging agents
b3924	316407.85676136	1.2e-124	452.6	Escherichia	fpr	GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004324,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0010035,GO:0016043,GO:0016052,GO:0016226,GO:0016491,GO:0016730,GO:0016731,GO:0019318,GO:0019320,GO:0022607,GO:0031163,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0055114,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901575,GO:1901700	1.18.1.2,1.19.1.1	ko:K00528			R10159		ko00000,ko01000			iECIAI39_1322.ECIAI39_3072,iEcSMS35_1347.EcSMS35_4364	Escherichia	1MW37@1224,1RR95@1236,3XMVI@561,COG1018@1,COG1018@2	NA|NA|NA	C	Transports electrons between flavodoxin or ferredoxin and NADPH. Reduces flavodoxin 1, flavodoxin 2 and ferredoxin, ferredoxin being the kinetically and thermodynamically preferred partner. Required for the activation of several enzymes such as pyruvate formate-lyase, anaerobic ribonucleotide reductase and cobalamin-dependent methionine synthase
b3925	198214.SF4003	1.8e-184	651.7	Gammaproteobacteria													Escherichia	1MUB1@1224,1RR0E@1236,COG1494@1,COG1494@2	NA|NA|NA	G	Fructose-1,6-bisphosphatase
b3926	155864.EDL933_5255	9e-297	1025.4	Escherichia	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019405,GO:0019563,GO:0019751,GO:0033554,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:1901575,GO:1901615,GO:1901616	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626		R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147			iE2348C_1286.E2348C_4230,iECNA114_1301.ECNA114_4065,iECSF_1327.ECSF_3786	Escherichia	1MUP7@1224,1RMAF@1236,3XN2R@561,COG0554@1,COG0554@2	NA|NA|NA	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
b3927	155864.EDL933_5256	5.4e-158	563.5	Escherichia	glpF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009987,GO:0010035,GO:0010038,GO:0015144,GO:0015166,GO:0015168,GO:0015254,GO:0015267,GO:0015318,GO:0015791,GO:0015793,GO:0015850,GO:0016020,GO:0022803,GO:0022857,GO:0034219,GO:0042221,GO:0044464,GO:0046689,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071241,GO:0071248,GO:0071288,GO:0071702,GO:0071944,GO:1901618		ko:K02440					ko00000,ko02000	1.A.8.1,1.A.8.2		iAF1260.b3927,iAPECO1_1312.APECO1_2542,iB21_1397.B21_03761,iBWG_1329.BWG_3596,iEC042_1314.EC042_4301,iEC55989_1330.EC55989_4405,iECABU_c1320.ECABU_c44330,iECBD_1354.ECBD_4097,iECB_1328.ECB_03812,iECDH10B_1368.ECDH10B_4116,iECDH1ME8569_1439.ECDH1ME8569_3796,iECD_1391.ECD_03812,iECED1_1282.ECED1_4629,iECH74115_1262.ECH74115_5382,iECIAI1_1343.ECIAI1_4132,iECNA114_1301.ECNA114_4066,iECO103_1326.ECO103_4601,iECO111_1330.ECO111_4750,iECO26_1355.ECO26_4658,iECOK1_1307.ECOK1_4395,iECP_1309.ECP_4136,iECS88_1305.ECS88_4377,iECSE_1348.ECSE_4216,iECSF_1327.ECSF_3787,iECSP_1301.ECSP_4990,iECUMN_1333.ECUMN_4455,iECW_1372.ECW_m4279,iECs_1301.ECs4852,iEKO11_1354.EKO11_4388,iETEC_1333.ETEC_4196,iEcDH1_1363.EcDH1_4058,iEcE24377_1341.EcE24377A_4461,iEcSMS35_1347.EcSMS35_4367,iEcolC_1368.EcolC_4091,iG2583_1286.G2583_4732,iJO1366.b3927,iJR904.b3927,iLF82_1304.LF82_0868,iNRG857_1313.NRG857_19605,iSSON_1240.SSON_4096,iUMNK88_1353.UMNK88_4764,iUTI89_1310.UTI89_C4511,iWFL_1372.ECW_m4279,iY75_1357.Y75_RS17425,iZ_1308.Z5472,ic_1306.c4879	Escherichia	1MXTJ@1224,1RP2X@1236,3XNW4@561,COG0580@1,COG0580@2	NA|NA|NA	G	Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols
b3928	1005994.GTGU_03651	1.3e-08	65.5	Gammaproteobacteria													Escherichia	1MZJE@1224,1S8TG@1236,COG3074@1,COG3074@2	NA|NA|NA	D	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA
b3929	155864.EDL933_5260	1.9e-86	325.1	Escherichia	rraA	GO:0003674,GO:0004857,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008428,GO:0009892,GO:0009894,GO:0009895,GO:0010605,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0032069,GO:0032074,GO:0043086,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1902369		ko:K02553					ko00000,ko03019			iJR904.b3929	Escherichia	1RH18@1224,1RS9U@1236,3XMGB@561,COG0684@1,COG0684@2	NA|NA|NA	H	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome
b3930	316407.85676130	1.2e-166	592.4	Escherichia	menA	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006			iECH74115_1262.ECH74115_5387,iG2583_1286.G2583_4737	Escherichia	1MXQQ@1224,1RPW5@1236,3XNGM@561,COG1575@1,COG1575@2	NA|NA|NA	H	Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK)
b3931	155864.EDL933_5262	1e-243	849.0	Escherichia	hslU	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369		ko:K03667					ko00000,ko03110				Escherichia	1MVK9@1224,1RMYV@1236,3XMJI@561,COG1220@1,COG1220@2	NA|NA|NA	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
b3932	754331.AEME01000001_gene818	5.5e-92	343.6	Escherichia	hslV	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	3.4.25.2	ko:K01419					ko00000,ko01000,ko01002				Escherichia	1MVF2@1224,1RP7P@1236,3XP2F@561,COG5405@1,COG5405@2	NA|NA|NA	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
b3933	155864.EDL933_5264	2.9e-115	421.8	Escherichia	ftsN	GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0030428,GO:0031224,GO:0031226,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047		ko:K03591					ko00000,ko03036				Escherichia	1PWIT@1224,1RNC1@1236,3XNQA@561,COG3087@1,COG3087@2	NA|NA|NA	D	Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases
b3934	198214.SF4012	1.7e-193	681.8	Gammaproteobacteria													Escherichia	1MVUR@1224,1RN8T@1236,COG1609@1,COG1609@2	NA|NA|NA	K	transcriptional
b3935	316407.85676125	0.0	1466.8	Escherichia	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576		ko:K04066	ko03440,map03440				ko00000,ko00001,ko01000,ko03400				Escherichia	1MUUZ@1224,1RPZ7@1236,3XNVC@561,COG1198@1,COG1198@2	NA|NA|NA	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
b3936	155864.EDL933_5268	8.5e-36	155.6	Escherichia	rpmE	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904		ko:K02909	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1MZ69@1224,1SCMH@1236,3XPZ0@561,COG0254@1,COG0254@2	NA|NA|NA	J	Binds the 23S rRNA
b3937	316407.85676123	4.2e-112	410.6	Escherichia	yiiX												Escherichia	1RBGX@1224,1S01D@1236,3XN9V@561,COG3863@1,COG3863@2	NA|NA|NA	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
b3938	155864.EDL933_5273	1.8e-53	214.9	Escherichia	metJ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K03764					ko00000,ko03000				Escherichia	1RH3B@1224,1S5ZV@1236,3XPPY@561,COG3060@1,COG3060@2	NA|NA|NA	K	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
b3939	316407.85676121	9.9e-219	765.8	Escherichia	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000			iAF1260.b3939,iBWG_1329.BWG_3608,iECDH10B_1368.ECDH10B_4128,iECDH1ME8569_1439.ECDH1ME8569_3808,iETEC_1333.ETEC_4208,iEcDH1_1363.EcDH1_4046,iEcHS_1320.EcHS_A4172,iEcolC_1368.EcolC_4076,iJO1366.b3939,iJR904.b3939,iUMNK88_1353.UMNK88_4777,iUTI89_1310.UTI89_C4524,iY75_1357.Y75_RS17365	Escherichia	1MU57@1224,1RMCV@1236,3XNGS@561,COG0626@1,COG0626@2	NA|NA|NA	E	Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma- replacement reaction. In the absence of thiol, catalyzes gamma- elimination to form 2-oxobutanoate, succinate and ammonia
b3940	316407.85676120	0.0	1607.4	Escherichia	metL	GO:0003674,GO:0003824,GO:0004072,GO:0004412,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3,2.7.2.4	ko:K12525	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000			iUMNK88_1353.UMNK88_4778	Escherichia	1MW3H@1224,1RN1G@1236,3XPCP@561,COG0460@1,COG0460@2,COG0527@1,COG0527@2	NA|NA|NA	E	Homoserine dehydrogenase II
b3941	198214.SF4019	3.8e-170	604.0	Gammaproteobacteria													Escherichia	1MUC9@1224,1RMXS@1236,COG0685@1,COG0685@2	NA|NA|NA	E	Methylenetetrahydrofolate reductase
b3942	316407.85676118	0.0	1476.1	Escherichia	katG	GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0042802,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110		R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000			iG2583_1286.G2583_4754	Escherichia	1MUBF@1224,1RNA5@1236,3XNUR@561,COG0376@1,COG0376@2	NA|NA|NA	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
b3943	199310.c4901	6.2e-160	570.1	Escherichia	yijE	GO:0000099,GO:0000101,GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:1901682,GO:1903825,GO:1905039											Escherichia	1NEYM@1224,1RY44@1236,3XNAP@561,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
b3944	316407.85676116	9.2e-115	419.5	Escherichia	yijF			ko:K09974					ko00000				Escherichia	1RE1M@1224,1S44B@1236,3XN1E@561,COG3738@1,COG3738@2	NA|NA|NA	S	Domain of unknown function (DUF1287)
b3945	199310.c4904	4.1e-206	723.8	Escherichia	gldA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006066,GO:0006071,GO:0006081,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0008888,GO:0009056,GO:0009438,GO:0009987,GO:0015980,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019147,GO:0019400,GO:0019405,GO:0019563,GO:0019588,GO:0019662,GO:0019751,GO:0042180,GO:0042182,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046185,GO:0051596,GO:0055114,GO:0071704,GO:1901575,GO:1901615,GO:1901616	1.1.1.6	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100		R01034,R10715,R10717	RC00029,RC00117,RC00670	ko00000,ko00001,ko01000			iAF1260.b3945,iB21_1397.B21_03780,iBWG_1329.BWG_3614,iECABU_c1320.ECABU_c44570,iECBD_1354.ECBD_4078,iECB_1328.ECB_03831,iECDH10B_1368.ECDH10B_4134,iECDH1ME8569_1439.ECDH1ME8569_3814,iECD_1391.ECD_03831,iECED1_1282.ECED1_4651,iECIAI1_1343.ECIAI1_4154,iECNA114_1301.ECNA114_4086,iECO103_1326.ECO103_4702,iECO111_1330.ECO111_4771,iECO26_1355.ECO26_5062,iECP_1309.ECP_4159,iECSE_1348.ECSE_4239,iECSF_1327.ECSF_3807,iECW_1372.ECW_m4302,iEKO11_1354.EKO11_4366,iETEC_1333.ETEC_4214,iEcDH1_1363.EcDH1_4040,iEcE24377_1341.EcE24377A_4485,iEcHS_1320.EcHS_A4180,iEcolC_1368.EcolC_4070,iJO1366.b3945,iJR904.b3945,iLF82_1304.LF82_0835,iNRG857_1313.NRG857_19715,iSDY_1059.SDY_3780,iUMNK88_1353.UMNK88_4784,iWFL_1372.ECW_m4302,iY75_1357.Y75_RS17325,ic_1306.c4904	Escherichia	1MWAE@1224,1RN9F@1236,3XMX6@561,COG0371@1,COG0371@2	NA|NA|NA	C	Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions. In E.coli, an important role of GldA is also likely to regulate the intracellular level of dihydroxyacetone by catalyzing the reverse reaction, i.e. the conversion of dihydroxyacetone into glycerol. Possesses a broad substrate specificity, since it is also able to oxidize 1,2-propanediol and to reduce glycolaldehyde, methylglyoxal and hydroxyacetone into ethylene glycol, lactaldehyde and 1,2-propanediol, respectively
b3946	316407.85676114	6.8e-116	423.3	Escherichia	fsaB	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016832,GO:0097023		ko:K08314					ko00000,ko01000			iB21_1397.B21_03781,iECBD_1354.ECBD_4077,iECB_1328.ECB_03832,iECD_1391.ECD_03832,iECH74115_1262.ECH74115_5407,iECSP_1301.ECSP_5016,iECs_1301.ECs4875,iEcHS_1320.EcHS_A4181,iG2583_1286.G2583_4758,iZ_1308.Z5501	Escherichia	1MWQ8@1224,1RNWN@1236,3XQP0@561,COG0176@1,COG0176@2	NA|NA|NA	G	Catalyzes the reversible formation of fructose 6- phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction
b3947	316407.85676113	0.0	1634.8	Escherichia	ptsA		2.7.3.9	ko:K08483,ko:K11189,ko:K11201	ko02060,map02060	M00306			ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7			Escherichia	1MUT8@1224,1RN6R@1236,3XP7E@561,COG1080@1,COG1080@2,COG1762@1,COG1762@2,COG1925@1,COG1925@2	NA|NA|NA	G	Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport
b3949	316407.85676112	1.9e-187	661.8	Escherichia	frwC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563		ko:K11203		M00306			ko00000,ko00002,ko02000	4.A.2.1			Escherichia	1P0NB@1224,1RPQZ@1236,3XNJ3@561,COG1299@1,COG1299@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
b3950	155864.EDL933_5286	3.8e-48	197.2	Escherichia	frwB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582		ko:K11202		M00306			ko00000,ko00002,ko01000,ko02000	4.A.2.1			Escherichia	1RHSU@1224,1S6R1@1236,3XPSP@561,COG1445@1,COG1445@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport
b3951	316407.85676110	0.0	1525.8	Escherichia	pflD		2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120		R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_5411,iECSP_1301.ECSP_5020,iECs_1301.ECs4880,iZ_1308.Z5507	Escherichia	1MWBF@1224,1RMEK@1236,3XNTU@561,COG1882@1,COG1882@2	NA|NA|NA	C	formate C-acetyltransferase activity
b3952	316407.85676109	1.9e-166	591.7	Escherichia	pflC		1.97.1.4	ko:K04069			R04710		ko00000,ko01000			e_coli_core.b3952,iAF1260.b3952,iAPECO1_1312.APECO1_2515,iBWG_1329.BWG_3620,iECDH10B_1368.ECDH10B_4140,iECDH1ME8569_1439.ECDH1ME8569_3820,iEcDH1_1363.EcDH1_4034,iJO1366.b3952,iJR904.b3952,iLF82_1304.LF82_1623,iNRG857_1313.NRG857_19745,iY75_1357.Y75_RS17295	Escherichia	1PD9E@1224,1RQG5@1236,3XN6N@561,COG1180@1,COG1180@2	NA|NA|NA	O	Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
b3953	316407.85676108	1.6e-55	221.9	Escherichia	frwD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582		ko:K11202		M00306			ko00000,ko00002,ko01000,ko02000	4.A.2.1			Escherichia	1RICG@1224,1S65D@1236,3XPRU@561,COG1445@1,COG1445@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane
b3954	316407.85676107	9e-161	572.8	Escherichia	yijO	GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141											Escherichia	1N7DZ@1224,1RN9G@1236,3XN7P@561,COG2207@1,COG2207@2	NA|NA|NA	K	transcriptional regulator
b3955	316407.85676106	0.0	1176.8	Escherichia	eptC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016776,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509		ko:K19353	ko00540,map00540				ko00000,ko00001,ko01000,ko01005				Escherichia	1MWS7@1224,1RQI2@1236,3XMV4@561,COG2194@1,COG2194@2	NA|NA|NA	S	Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core
b3956	316407.85676105	0.0	1757.7	Escherichia	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000			iSFV_1184.SFV_4025	Escherichia	1MUD5@1224,1RPTP@1236,3XM42@561,COG2352@1,COG2352@2	NA|NA|NA	H	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
b3957	316407.85676104	1.2e-229	802.0	Escherichia	argE	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0008777,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_4488	Escherichia	1MVBR@1224,1RNDG@1236,3XMEN@561,COG0624@1,COG0624@2	NA|NA|NA	E	Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde
b3958	316407.85676103	1.8e-192	678.3	Escherichia	argC	GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000			iSSON_1240.SSON_4131	Escherichia	1MVJ6@1224,1RNMX@1236,3XM7I@561,COG0002@1,COG0002@2	NA|NA|NA	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
b3959	511145.b3959	3e-139	501.1	Escherichia	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0033554,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2508,iB21_1397.B21_03793,iEC55989_1330.EC55989_4441,iECB_1328.ECB_03844,iECDH10B_1368.ECDH10B_4147,iECDH1ME8569_1439.ECDH1ME8569_3827,iECD_1391.ECD_03844,iECH74115_1262.ECH74115_5419,iECIAI1_1343.ECIAI1_4167,iECO103_1326.ECO103_4715,iECOK1_1307.ECOK1_4431,iECS88_1305.ECS88_4414,iECSE_1348.ECSE_4252,iETEC_1333.ETEC_4227,iEcE24377_1341.EcE24377A_4498,iEcHS_1320.EcHS_A4193,iEcolC_1368.EcolC_4057,iSbBS512_1146.SbBS512_E4445,iUMN146_1321.UM146_20050,iUMNK88_1353.UMNK88_4797,iUTI89_1310.UTI89_C4550,iY75_1357.Y75_RS17255	Escherichia	1MU17@1224,1RNKK@1236,3XN7Q@561,COG0548@1,COG0548@2	NA|NA|NA	F	Catalyzes the ATP-dependent phosphorylation of N-acetyl- L-glutamate
b3960	316407.85676101	6.1e-260	902.9	Escherichia	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147				Escherichia	1MUTU@1224,1RMA3@1236,3XMS6@561,COG0165@1,COG0165@2	NA|NA|NA	E	argininosuccinate lyase
b3961	155864.EDL933_5297	1.6e-171	608.6	Escherichia	oxyR	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001131,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0033554,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2000142,GO:2001141		ko:K04761	ko02026,map02026				ko00000,ko00001,ko03000				Escherichia	1MVA1@1224,1RPAJ@1236,3XNXK@561,COG0583@1,COG0583@2	NA|NA|NA	K	Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto-aggregation ability
b3962	316407.85676099	1.5e-274	951.4	Escherichia	sthA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008746,GO:0009987,GO:0016491,GO:0016651,GO:0016652,GO:0019725,GO:0036094,GO:0042592,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0055114,GO:0065007,GO:0065008,GO:0097159,GO:1901265,GO:1901363	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100		R00112	RC00001	ko00000,ko00001,ko01000			iECED1_1282.ECED1_4669,iECs_1301.ECs4891,iZ_1308.Z5521	Escherichia	1MVVE@1224,1RMJT@1236,3XN5G@561,COG1249@1,COG1249@2	NA|NA|NA	C	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation
b3963	155864.EDL933_5301	2.3e-122	444.9	Escherichia	fabR	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K22105					ko00000,ko03000				Escherichia	1MUJ5@1224,1RN9W@1236,3XNXE@561,COG1309@1,COG1309@2	NA|NA|NA	K	fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer
b3964	155864.EDL933_5302	7.1e-59	233.0	Escherichia	yijD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1RH5N@1224,1S68Y@1236,2ARMX@1,31GYK@2,3XPPP@561	NA|NA|NA	S	Protein of unknown function (DUF1422)
b3965	316407.85676096	1.4e-209	735.3	Escherichia	trmA	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0019843,GO:0030488,GO:0030696,GO:0030697,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363	2.1.1.35	ko:K00557					ko00000,ko01000,ko03016				Escherichia	1MY45@1224,1RN2B@1236,3XNI9@561,COG2265@1,COG2265@2	NA|NA|NA	J	Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA)
b3966	316407.85676095	0.0	1263.8	Escherichia	btuB	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705		ko:K16092					ko00000,ko02000	1.B.14.3		iECB_1328.ECB_03851,iECP_1309.ECP_4183,iSF_1195.SF4048,iS_1188.S3696	Escherichia	1MW63@1224,1RMFJ@1236,3XN0V@561,COG4206@1,COG4206@2	NA|NA|NA	P	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB
b3967	316407.85676094	9.4e-158	562.8	Escherichia	murI	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100		R00260	RC00302	ko00000,ko00001,ko01000,ko01011			iAPECO1_1312.APECO1_2496,iEC042_1314.EC042_4342,iECOK1_1307.ECOK1_4443,iECS88_1305.ECS88_4426,iUMN146_1321.UM146_20110,iUTI89_1310.UTI89_C4562	Escherichia	1NAI2@1224,1RPU9@1236,3XN8U@561,COG0796@1,COG0796@2	NA|NA|NA	M	Provides the (R)-glutamate required for cell wall biosynthesis
b3972	316407.85676093	7.4e-202	709.5	Escherichia	murB	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100		R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011			iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845	Escherichia	1MXDH@1224,1RNXK@1236,3XNPK@561,COG0812@1,COG0812@2	NA|NA|NA	M	Cell wall formation
b3973	316407.85676092	4e-181	640.6	Escherichia	birA	GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100		R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000				Escherichia	1MWCC@1224,1RNGC@1236,3XN5Y@561,COG0340@1,COG0340@2,COG1654@1,COG1654@2	NA|NA|NA	K	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
b3974	155864.EDL933_5308	6.3e-179	633.3	Escherichia	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000			iECDH1ME8569_1439.ECDH1ME8569_3838,iECH74115_1262.ECH74115_5439,iECSE_1348.ECSE_4265,iECSF_1327.ECSF_3833,iECSP_1301.ECSP_5045,iECW_1372.ECW_m4332,iEcDH1_1363.EcDH1_4016,iEcolC_1368.EcolC_4046,iSFV_1184.SFV_4047,iSFxv_1172.SFxv_4418,iWFL_1372.ECW_m4332,iZ_1308.Z5545	Escherichia	1MV3M@1224,1RNXX@1236,3XMR3@561,COG1072@1,COG1072@2	NA|NA|NA	F	Pantothenic acid kinase
b3980	155864.EDL933_5310	1.9e-225	788.1	Escherichia	tufB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944		ko:K02358					ko00000,ko03012,ko03029,ko04147				Escherichia	1MVC0@1224,1RMYX@1236,3XN6C@561,COG0050@1,COG0050@2	NA|NA|NA	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
b3981	1440052.EAKF1_ch1938c	3.2e-57	227.6	Escherichia	secE	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680		ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335			ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2			Escherichia	1RDI9@1224,1S3PA@1236,3XPKH@561,COG0690@1,COG0690@2	NA|NA|NA	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
b3982	155864.EDL933_5312	7.4e-100	369.8	Escherichia	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141		ko:K02601					ko00000,ko03009,ko03021				Escherichia	1MU14@1224,1RMW0@1236,3XNVU@561,COG0250@1,COG0250@2	NA|NA|NA	K	Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA
b3983	1197719.A464_4165	3.7e-70	270.8	Salmonella													Escherichia	1RA2M@1224,1S22R@1236,3ZIPY@590,COG0080@1,COG0080@2	NA|NA|NA	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
b3984	155864.EDL933_5314	1.1e-119	436.0	Escherichia	rplA	GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006417,GO:0006446,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904,GO:2000112,GO:2000113		ko:K02863	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1MUE6@1224,1RMDW@1236,3XMSJ@561,COG0081@1,COG0081@2	NA|NA|NA	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release
b3985	1440052.EAKF1_ch1934c	1e-79	302.8	Escherichia	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113		ko:K02864	ko03010,map03010	M00178,M00179			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1RAN5@1224,1S286@1236,3XM5M@561,COG0244@1,COG0244@2	NA|NA|NA	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
b3986	155864.EDL933_5316	3.6e-50	204.1	Escherichia	rplL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0046983,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02935	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1RGU4@1224,1S5V7@1236,3XPRN@561,COG0222@1,COG0222@2	NA|NA|NA	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation
b3987	155864.EDL933_5317	0.0	2641.3	Escherichia	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030880,GO:0032991,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Escherichia	1MUC4@1224,1RMK0@1236,3XMJ3@561,COG0085@1,COG0085@2	NA|NA|NA	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
b3988	155864.EDL933_5318	0.0	2688.3	Escherichia	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030880,GO:0032991,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400				Escherichia	1MU3M@1224,1RPYH@1236,3XMYU@561,COG0086@1,COG0086@2	NA|NA|NA	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
b3989	316407.85676081	1e-101	375.9	Escherichia	yjaZ												Escherichia	1NI52@1224,1SGPA@1236,2DM70@1,31ZPH@2,3XQT4@561	NA|NA|NA		
b3990	316407.85676080	1.3e-220	771.9	Escherichia	thiH	GO:0003674,GO:0003824,GO:0005488,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0036355,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100		R10246	RC01434,RC03095	ko00000,ko00001,ko01000			iSF_1195.SF4062,iSFxv_1172.SFxv_4429,iS_1188.S3673	Escherichia	1MXK0@1224,1RNTV@1236,3XNBA@561,COG0502@1,COG0502@2	NA|NA|NA	H	2-iminoacetate synthase activity
b3991	316407.85676079	3.7e-137	494.2	Escherichia	thiG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100		R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000			iECABU_c1320.ECABU_c45060,iECO26_1355.ECO26_5099,ic_1306.c4947	Escherichia	1N0N5@1224,1RMPD@1236,3XN6M@561,COG2022@1,COG2022@2	NA|NA|NA	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
b4407	316407.85676078	1.2e-28	131.7	Escherichia	thiS			ko:K03154	ko04122,map04122				ko00000,ko00001			iAF1260.b4407,iBWG_1329.BWG_3651,iECDH10B_1368.ECDH10B_4180,iECDH1ME8569_1439.ECDH1ME8569_3851,iECDH1ME8569_1439.EcDH1_4003,iEcDH1_1363.EcDH1_4003,iEcolC_1368.EcolC_4034,iJO1366.b4407,iJR904.b4407,iUMNK88_1353.UMNK88_4832,iY75_1357.Y75_RS17090	Escherichia	1N6ZF@1224,1SCFT@1236,3XPYX@561,COG2104@1,COG2104@2	NA|NA|NA	H	thiamine biosynthesis protein ThiS
b3992	316407.85676077	2.3e-131	474.9	Escherichia	thiF	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0008270,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.7.73	ko:K03148	ko00730,ko01100,ko04122,map00730,map01100,map04122		R07459	RC00043	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_2482,iECDH1ME8569_1439.ECDH1ME8569_3852,iECDH1ME8569_1439.EcDH1_4002,iECIAI39_1322.ECIAI39_4382,iEcDH1_1363.EcDH1_4002	Escherichia	1MW7H@1224,1RPJ3@1236,3XMN0@561,COG0476@1,COG0476@2	NA|NA|NA	H	ubiquitin-like modifier activating enzyme activity
b3993	316407.85676076	1.5e-112	412.1	Escherichia	thiE	GO:0000287,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000			iE2348C_1286.E2348C_4300,iSSON_1240.SSON_4166	Escherichia	1RDSU@1224,1SYGR@1236,3XMY1@561,COG0352@1,COG0352@2	NA|NA|NA	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)
b3994	316407.85676075	0.0	1297.7	Escherichia	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c45100	Escherichia	1MUVV@1224,1RP1F@1236,3XMHV@561,COG0422@1,COG0422@2	NA|NA|NA	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
b3995	155864.EDL933_5326	1.7e-84	318.5	Escherichia	rsd	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141		ko:K07740					ko00000				Escherichia	1RHBB@1224,1S420@1236,3XPHA@561,COG3160@1,COG3160@2	NA|NA|NA	K	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
b3996	316407.85676073	1.4e-152	545.4	Escherichia	nudC	GO:0003674,GO:0003824,GO:0004551,GO:0005488,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0035529,GO:0043167,GO:0043169,GO:0046872,GO:0046914	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146		R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000			iAF1260.b3996,iB21_1397.B21_03826,iBWG_1329.BWG_3656,iEC55989_1330.EC55989_4481,iECBD_1354.ECBD_4036,iECB_1328.ECB_03873,iECDH10B_1368.ECDH10B_4185,iECDH1ME8569_1439.ECDH1ME8569_3856,iECD_1391.ECD_03873,iECIAI1_1343.ECIAI1_4211,iECO103_1326.ECO103_4745,iECO111_1330.ECO111_4813,iECO26_1355.ECO26_5105,iECSE_1348.ECSE_4284,iECW_1372.ECW_m4355,iEKO11_1354.EKO11_4325,iETEC_1333.ETEC_4256,iEcDH1_1363.EcDH1_3998,iEcE24377_1341.EcE24377A_4539,iEcHS_1320.EcHS_A4230,iEcolC_1368.EcolC_4029,iJO1366.b3996,iSSON_1240.SSON_4169,iUMNK88_1353.UMNK88_4837,iWFL_1372.ECW_m4355,iY75_1357.Y75_RS17065	Escherichia	1QGCX@1224,1RP0Y@1236,3XMM1@561,COG2816@1,COG2816@2	NA|NA|NA	L	Belongs to the Nudix hydrolase family. NudC subfamily
b3997	316407.85676072	9.4e-208	729.2	Escherichia	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046394,GO:0046483,GO:0046501,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000			iSBO_1134.SBO_4018	Escherichia	1MUG1@1224,1RMDH@1236,3XN6T@561,COG0407@1,COG0407@2	NA|NA|NA	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
b3998	155864.EDL933_5329	2.5e-126	458.0	Escherichia	nfi	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0043737,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.7	ko:K05982					ko00000,ko01000,ko03400				Escherichia	1MWRN@1224,1RRYH@1236,3XMDC@561,COG1515@1,COG1515@2	NA|NA|NA	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA
b3999	316407.85676070	2.3e-107	394.8	Escherichia	yjaG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09891					ko00000				Escherichia	1MWSN@1224,1RQDG@1236,3XPD1@561,COG3068@1,COG3068@2	NA|NA|NA	S	Protein of unknown function (DUF416)
b4000	1440052.EAKF1_ch1916c	3.6e-39	167.2	Escherichia	hupA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1990104,GO:1990178		ko:K05787					ko00000,ko03032,ko03036,ko03400				Escherichia	1MZ5B@1224,1S8VH@1236,3XPW4@561,COG0776@1,COG0776@2	NA|NA|NA	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions
b4001	316407.85676068	1.6e-115	422.2	Escherichia	yjaH												Escherichia	1QFI0@1224,1RPY5@1236,28HWS@1,2Z82N@2,3XNF7@561	NA|NA|NA	S	Protein of unknown function (DUF1481)
b4002	155864.EDL933_5333	6.4e-59	233.4	Escherichia	zraP	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0008270,GO:0016151,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050897		ko:K07803	ko02020,map02020				ko00000,ko00001,ko03110				Escherichia	1RI83@1224,1S6TF@1236,3XPNA@561,COG3678@1,COG3678@2	NA|NA|NA	NPTU	Binds zinc. Could be an important component of the zinc- balancing mechanism
b4003	316407.85676066	5.3e-259	899.8	Escherichia	zraS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010288,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071284,GO:0071294,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07709	ko02020,map02020	M00499			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1RCM9@1224,1RSI4@1236,3XPH1@561,COG4191@1,COG4191@2	NA|NA|NA	T	Member of the two-component regulatory system ZraS ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium
b4004	316407.85676065	1.9e-242	844.7	Escherichia	zraR	GO:0000156,GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0023052,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576		ko:K07713	ko02020,map02020	M00499			ko00000,ko00001,ko00002,ko02022				Escherichia	1MU0N@1224,1RMCK@1236,3XMIG@561,COG2204@1,COG2204@2	NA|NA|NA	K	Member of the two-component regulatory system ZraS ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon
b4005	316407.85676064	7e-250	869.4	Escherichia	purD	GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859	Escherichia	1MUAH@1224,1RNS4@1236,3XNXC@561,COG0151@1,COG0151@2	NA|NA|NA	F	Belongs to the GARS family
b4006	316407.85676063	2.4e-300	1037.3	Escherichia	purH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147			iEcHS_1320.EcHS_A4240	Escherichia	1MUDQ@1224,1RMWS@1236,3XNEK@561,COG0138@1,COG0138@2	NA|NA|NA	F	Bifunctional purine biosynthesis protein PurH
b4011	316407.85676763	1.9e-62	245.0	Gammaproteobacteria													Escherichia	1ND8N@1224,1SFK4@1236,2DQT3@1,338GQ@2	NA|NA|NA	S	single-species biofilm formation on inanimate substrate
b4012	316407.85676764	2.4e-80	304.7	Escherichia	yjaB			ko:K03827					ko00000,ko01000				Escherichia	1RI35@1224,1S362@1236,3XPMC@561,COG0454@1,COG0456@2	NA|NA|NA	K	transferase activity, transferring acyl groups
b4013	316407.85676765	3.5e-182	644.0	Escherichia	metA	GO:0003674,GO:0003824,GO:0008374,GO:0008899,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000			iECUMN_1333.ECUMN_4539,iSBO_1134.SBO_4033,iSbBS512_1146.SbBS512_E4507	Escherichia	1MV64@1224,1RM7T@1236,3XNKY@561,COG1897@1,COG1897@2	NA|NA|NA	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine
b4014	316407.85676766	0.0	1090.1	Escherichia	aceB	GO:0003674,GO:0003824,GO:0004474,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044464,GO:0046487,GO:0046912,GO:0071704	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000			iEC55989_1330.EC55989_4499,iLF82_1304.LF82_0013,iNRG857_1313.NRG857_20010	Escherichia	1MVEV@1224,1RPVI@1236,3XP4H@561,COG2225@1,COG2225@2	NA|NA|NA	H	Belongs to the malate synthase family
b4015	316407.85676767	9.3e-250	869.0	Escherichia	aceA	GO:0003674,GO:0003824,GO:0004451,GO:0005488,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046487,GO:0071704	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000			e_coli_core.b4015,iAF1260.b4015,iB21_1397.B21_03847,iBWG_1329.BWG_3671,iE2348C_1286.E2348C_4318,iEC042_1314.EC042_4377,iEC55989_1330.EC55989_4500,iECABU_c1320.ECABU_c45310,iECBD_1354.ECBD_4022,iECB_1328.ECB_03887,iECDH10B_1368.ECDH10B_4204,iECDH1ME8569_1439.ECDH1ME8569_3871,iECD_1391.ECD_03887,iECED1_1282.ECED1_4722,iECIAI1_1343.ECIAI1_4235,iECIAI39_1322.ECIAI39_4401,iECNA114_1301.ECNA114_4164,iECO103_1326.ECO103_4759,iECO111_1330.ECO111_4827,iECO26_1355.ECO26_5119,iECP_1309.ECP_4225,iECSE_1348.ECSE_4300,iECSF_1327.ECSF_3865,iECUMN_1333.ECUMN_4541,iECW_1372.ECW_m4374,iEKO11_1354.EKO11_4310,iETEC_1333.ETEC_4270,iEcDH1_1363.EcDH1_3982,iEcE24377_1341.EcE24377A_4557,iEcHS_1320.EcHS_A4249,iEcSMS35_1347.EcSMS35_4469,iEcolC_1368.EcolC_4015,iJO1366.b4015,iJR904.b4015,iLF82_1304.LF82_0012,iNRG857_1313.NRG857_20015,iSDY_1059.SDY_4328,iUMNK88_1353.UMNK88_4859,iWFL_1372.ECW_m4374,iY75_1357.Y75_RS20880	Escherichia	1MWIF@1224,1RQAK@1236,3XNEM@561,COG2224@1,COG2224@2	NA|NA|NA	C	Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates
b4016	316407.85676768	0.0	1191.0	Escherichia	aceK	GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.11.5	ko:K00906					ko00000,ko01000				Escherichia	1MVRB@1224,1RMC2@1236,3XM4V@561,COG4579@1,COG4579@2	NA|NA|NA	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation
b4017	316407.85676769	1.9e-239	835.5	Gammaproteobacteria													Escherichia	1QWC1@1224,1T2TD@1236,32YAJ@2,COG0666@1	NA|NA|NA	S	Corresponds to locus_tag
b4018	155864.EDL933_5345	3.1e-150	537.7	Escherichia	iclR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K13641					ko00000,ko03000				Escherichia	1MUNW@1224,1RY9N@1236,3XM44@561,COG1414@1,COG1414@2	NA|NA|NA	K	Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form
b4019	316407.85676771	0.0	2449.5	Escherichia	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000			iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545	Escherichia	1MV6G@1224,1RMYD@1236,3XM8P@561,COG0646@1,COG0646@2,COG1410@1,COG1410@2	NA|NA|NA	H	Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate
b4020	198214.SF4086	2.2e-285	987.6	Gammaproteobacteria													Escherichia	1MUDE@1224,1RNMM@1236,COG1283@1,COG1283@2	NA|NA|NA	P	Na Pi-Cotransporter
b4021	155864.EDL933_5348	7.3e-129	466.5	Escherichia	pepE	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	3.4.13.21	ko:K05995					ko00000,ko01000,ko01002				Escherichia	1NBN5@1224,1RYUM@1236,3XMR5@561,COG3340@1,COG3340@2	NA|NA|NA	E	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids
b4022	316407.85676774	1.9e-161	575.1	Escherichia	rluF	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.21	ko:K06182					ko00000,ko01000,ko03009				Escherichia	1MXQE@1224,1RMC7@1236,3XNF8@561,COG1187@1,COG1187@2	NA|NA|NA	J	Catalyzes the synthesis of pseudouridine from uracil- 2604 in 23S ribosomal RNA
b4023	316407.85676775	4.3e-40	170.2	Escherichia	yjbD												Escherichia	1RHBT@1224,1S7BQ@1236,2B37U@1,31VVV@2,3XPTX@561	NA|NA|NA	S	YjbD family (DUF3811)
b4024	316407.85676776	2.1e-244	851.3	Escherichia	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_4739	Escherichia	1MW3H@1224,1RMJ6@1236,3XMQD@561,COG0527@1,COG0527@2	NA|NA|NA	E	Belongs to the aspartokinase family
b4025	155864.EDL933_5360	0.0	1121.7	Escherichia	pgi	GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147			iEcSMS35_1347.EcSMS35_4486	Escherichia	1MUFP@1224,1RNIT@1236,3XNB8@561,COG0166@1,COG0166@2	NA|NA|NA	F	Belongs to the GPI family
b4027	316407.85676779	1.1e-118	432.6	Escherichia	yjbF	GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576											Escherichia	1N1VT@1224,1RMP6@1236,28M8B@1,2ZAMG@2,3XNZQ@561	NA|NA|NA	M	extracellular polysaccharide metabolic process
b4028	316407.85676780	3.1e-133	481.1	Escherichia	yjbG	GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576											Escherichia	1QUFK@1224,1T1X9@1236,29T7B@1,2ZAUX@2,3XRNE@561	NA|NA|NA	S	extracellular polysaccharide metabolic process
b4029	316407.85676781	0.0	1441.8	Escherichia	yjbH	GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576											Escherichia	1MX3H@1224,1RQKV@1236,3XMA1@561,COG4775@1,COG4775@2	NA|NA|NA	M	extracellular polysaccharide metabolic process
b4620	199310.c4999	7.7e-45	186.0	Escherichia	yjbT												Escherichia	1QIN6@1224,1TGHF@1236,2AV2P@1,31KSJ@2,3XR2T@561	NA|NA|NA	S	Uncharacterised protein family
b4030	198214.SF4175	5.8e-65	253.4	Gammaproteobacteria													Escherichia	1RD8R@1224,1S4FE@1236,COG3223@1,COG3223@2	NA|NA|NA	S	Protein PsiE homolog
b4031	155864.EDL933_5368	3.1e-278	963.8	Escherichia	xylE	GO:0003674,GO:0005215,GO:0005351,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0015075,GO:0015077,GO:0015078,GO:0015144,GO:0015145,GO:0015146,GO:0015148,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015519,GO:0015672,GO:0015749,GO:0015750,GO:0015753,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600		ko:K08138					ko00000,ko02000	2.A.1.1.3		iECIAI1_1343.ECIAI1_4259,iECSE_1348.ECSE_4322	Escherichia	1MVKJ@1224,1RMHJ@1236,3XN94@561,COG0477@1,COG0477@2,COG2814@2	NA|NA|NA	EGP	Major facilitator Superfamily
b4032	155864.EDL933_5369	1.4e-159	568.9	Escherichia	malG	GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351		ko:K10110	ko02010,map02010	M00194			ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.22		iSSON_1240.SSON_4210	Escherichia	1QA3Z@1224,1RQ00@1236,3XNEJ@561,COG3833@1,COG3833@2	NA|NA|NA	P	probably responsible for the translocation of the substrate across the membrane
b4033	316407.85676785	1e-295	1021.9	Escherichia	malF	GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009987,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351		ko:K10109	ko02010,map02010	M00194			ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.22		iZ_1308.Z5631	Escherichia	1MXKR@1224,1RN6B@1236,3XP8S@561,COG1175@1,COG1175@2	NA|NA|NA	G	probably responsible for the translocation of the substrate across the membrane
b4034	155864.EDL933_5371	4.1e-228	797.0	Escherichia	malE	GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006928,GO:0006935,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009593,GO:0009605,GO:0009730,GO:0009743,GO:0009987,GO:0010033,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016477,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034285,GO:0034286,GO:0034288,GO:0034289,GO:0040011,GO:0042221,GO:0042330,GO:0042597,GO:0042956,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0048030,GO:0048870,GO:0050896,GO:0051179,GO:0051234,GO:0051606,GO:0051674,GO:0051716,GO:0055052,GO:0060326,GO:0070492,GO:0070887,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901700,GO:1901982,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K10108	ko02010,ko02030,map02010,map02030	M00194			ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.22		iECUMN_1333.ECUMN_4568	Escherichia	1N9AE@1224,1RN4E@1236,3XMUV@561,COG2182@1,COG2182@2	NA|NA|NA	P	Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides
b4035	155864.EDL933_5372	5.2e-209	733.4	Escherichia	malK	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008134,GO:0008144,GO:0008150,GO:0008643,GO:0009898,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0031226,GO:0031234,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033037,GO:0033613,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042956,GO:0043167,GO:0043168,GO:0043190,GO:0043211,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351		ko:K10111	ko02010,map02010	M00194,M00200,M00204,M00207,M00491			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1		ic_1306.c5005	Escherichia	1MU3I@1224,1RM9E@1236,3XN2Y@561,COG3842@1,COG3842@2	NA|NA|NA	P	Part of the ABC transporter complex MalEFGK involved in maltose maltodextrin import. Responsible for energy coupling to the transport system
b4036	316407.85676788	5.4e-269	932.9	Escherichia	lamB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009279,GO:0009987,GO:0015144,GO:0015159,GO:0015267,GO:0015288,GO:0015774,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0022884,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0032991,GO:0033036,GO:0033037,GO:0033554,GO:0034219,GO:0042956,GO:0042958,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0046930,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071944,GO:0098796		ko:K02024					ko00000,ko02000	1.B.3.1.1		iEC55989_1330.EC55989_4527	Escherichia	1MX77@1224,1RPMF@1236,3XP8N@561,COG4580@1,COG4580@2	NA|NA|NA	M	Involved in the transport of maltose and maltodextrins
b4037	316407.85676789	1.9e-156	558.5	Escherichia	malM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464		ko:K05775					ko00000				Escherichia	1MY1F@1224,1RQ3A@1236,2C19D@1,2Z7PA@2,3XMDZ@561	NA|NA|NA	S	Maltose operon periplasmic
b4038	316407.85676790	5.6e-201	707.2	Bacteria													Escherichia	COG1357@1,COG1357@2	NA|NA|NA	S	protein homooligomerization
b4039	316407.85676791	1.8e-89	335.1	Escherichia	ubiC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.1.3.40	ko:K03181	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R01302	RC00491,RC02148	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z5638	Escherichia	1N8BF@1224,1SDX2@1236,3XRFH@561,COG3161@1,COG3161@2	NA|NA|NA	H	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway
b4040	155864.EDL933_5377	2.1e-136	491.9	Escherichia	ubiA	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008412,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006			iZ_1308.Z5639	Escherichia	1MV4Q@1224,1RMZ1@1236,3XNZT@561,COG0382@1,COG0382@2	NA|NA|NA	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
b4041	199310.c5011	0.0	1608.6	Escherichia	plsB	GO:0003674,GO:0003824,GO:0004366,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004			iECs_1301.ECs5024,iG2583_1286.G2583_4866	Escherichia	1MWZ6@1224,1RM7K@1236,3XNFZ@561,COG2937@1,COG2937@2	NA|NA|NA	I	Belongs to the GPAT DAPAT family
b4042	155864.EDL933_5379	6.2e-58	229.9	Escherichia	dgkA	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231		R02240	RC00002,RC00017	ko00000,ko00001,ko01000				Escherichia	1MZ3Q@1224,1S92I@1236,3XPP6@561,COG0818@1,COG0818@2	NA|NA|NA	M	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
b4043	1440052.EAKF1_ch1871c	1.1e-107	396.0	Escherichia	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356		M00729			ko00000,ko00002,ko01000,ko01002,ko03400				Escherichia	1MW80@1224,1RMXF@1236,3XP1V@561,COG1974@1,COG1974@2	NA|NA|NA	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
b4044	316407.85676796	5.1e-246	856.7	Escherichia	dinF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K03327					ko00000,ko02000	2.A.66.1			Escherichia	1MV6B@1224,1RPGF@1236,3XMFF@561,COG0534@1,COG0534@2	NA|NA|NA	V	antiporter activity
b4045	155864.EDL933_5382	3e-33	147.1	Escherichia	yjbJ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N6X4@1224,1SDHP@1236,3XQ1R@561,COG3237@1,COG3237@2	NA|NA|NA	S	Belongs to the UPF0337 (CsbD) family
b4046	198214.SF4159	5.4e-84	317.0	Gammaproteobacteria													Escherichia	1MZIW@1224,1S5ZI@1236,COG0735@1,COG0735@2	NA|NA|NA	P	belongs to the Fur family
b4047	316407.85676799	4.9e-30	136.7	Gammaproteobacteria													Escherichia	1NXYX@1224,1SQ8M@1236,2DW8T@1,33Z39@2	NA|NA|NA		
b4048	316407.85676800	3.6e-131	474.2	Gammaproteobacteria													Escherichia	1NTW1@1224,1SJIW@1236,2DUZ3@1,33T3G@2	NA|NA|NA	S	Protein of unknown function (DUF2713)
b4049	155864.EDL933_5385	6.8e-203	713.0	Escherichia	dusA	GO:0002943,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360		ko:K05539					ko00000,ko01000,ko03016				Escherichia	1MUY1@1224,1RN28@1236,3XP3Q@561,COG0042@1,COG0042@2	NA|NA|NA	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs
b4050	198214.SF4155	1.2e-14	85.5	Gammaproteobacteria													Escherichia	1N8FV@1224,1SCBJ@1236,2E8D0@1,332RI@2	NA|NA|NA	S	Phage Shock Protein G
b4051	316407.85676803	3.4e-180	637.5	Escherichia	qor	GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003960,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016651,GO:0016655,GO:0017091,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:1901363	1.6.5.5	ko:K00344					ko00000,ko01000				Escherichia	1MWBD@1224,1RPCQ@1236,3XNAN@561,COG0604@1,COG0604@2	NA|NA|NA	C	Quinone oxidoreductase
b4052	198214.SF4154	9.4e-264	915.6	Gammaproteobacteria													Escherichia	1MUG9@1224,1RPM2@1236,COG0305@1,COG0305@2	NA|NA|NA	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
b4053	198214.SF4152	2.8e-207	727.6	Gammaproteobacteria													Escherichia	1MV0Q@1224,1RM8U@1236,COG0787@1,COG0787@2	NA|NA|NA	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
b4054	316407.85676806	2e-227	794.7	Escherichia	tyrB	GO:0003674,GO:0003824,GO:0004838,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006532,GO:0006551,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0008793,GO:0009058,GO:0009066,GO:0009067,GO:0009072,GO:0009073,GO:0009081,GO:0009082,GO:0009094,GO:0009095,GO:0009098,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019292,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0033585,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050048,GO:0050662,GO:0070279,GO:0070547,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	2.6.1.57	ko:K00832	ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	M00024,M00025,M00034,M00040	R00694,R00734,R01731,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007			iECED1_1282.ECED1_4768,iECSE_1348.ECSE_4347,iLF82_1304.LF82_2339,iNRG857_1313.NRG857_20250,iUTI89_1310.UTI89_C4629	Escherichia	1MUT0@1224,1RN02@1236,3XMH8@561,COG1448@1,COG1448@2	NA|NA|NA	E	Broad-specificity enzyme that catalyzes the transamination of 2-ketoisocaproate, p-hydroxyphenylpyruvate, and phenylpyruvate to yield leucine, tyrosine, and phenylalanine, respectively. In vitro, is able to catalyze the conversion of beta-methyl phenylpyruvate to the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin produced by Streptomyces hygroscopicus NRRL3085
b4621	198214.SF4150	9.3e-16	89.0	Gammaproteobacteria													Escherichia	1NV8P@1224,1SNIK@1236,2DV4G@1,33U04@2	NA|NA|NA		
b4055	198214.SF4149	7.8e-134	483.0	Gammaproteobacteria													Escherichia	1PRRA@1224,1RP0N@1236,COG3700@1,COG3700@2	NA|NA|NA	S	Belongs to the class B bacterial acid phosphatase family
b4056	155864.EDL933_5394	1.9e-76	291.6	Escherichia	yjbQ												Escherichia	1RH13@1224,1S3VP@1236,3XNQ9@561,COG0432@1,COG0432@2	NA|NA|NA	S	Uncharacterised protein family UPF0047
b4057	155864.EDL933_5395	6.4e-60	236.5	Escherichia	yjbR												Escherichia	1RD85@1224,1S3PR@1236,3XPRK@561,COG2315@1,COG2315@2	NA|NA|NA	S	YjbR
b4058	198214.SF4146	0.0	1888.2	Gammaproteobacteria													Escherichia	1MW0W@1224,1RMS9@1236,COG0178@1,COG0178@2	NA|NA|NA	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
b4059	155864.EDL933_5397	2.1e-78	298.5	Escherichia	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363		ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440				ko00000,ko00001,ko03029,ko03032,ko03400				Escherichia	1RCWT@1224,1S3WP@1236,3XMYI@561,COG0629@1,COG0629@2	NA|NA|NA	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
b4060	155864.EDL933_5398	3.3e-43	180.6	Escherichia	yjcB												Escherichia	1RIMH@1224,1S71K@1236,2CRMS@1,32SPC@2,3XPTY@561	NA|NA|NA	S	Family of unknown function
b4061	316407.85676813	5.9e-307	1059.3	Escherichia	yjcC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008081,GO:0016020,GO:0016787,GO:0016788,GO:0042578,GO:0044464,GO:0071111,GO:0071944											Escherichia	1MVTH@1224,1RMDP@1236,3XNKJ@561,COG4943@1,COG4943@2	NA|NA|NA	T	May function as a c-di-GMP phosphodiesterase. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria. Overexpression reduces biofilm formation
b4062	155864.EDL933_5400	1.6e-54	218.4	Escherichia	soxS	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001098,GO:0001108,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006082,GO:0006089,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019219,GO:0019222,GO:0019243,GO:0019249,GO:0019752,GO:0031323,GO:0031326,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046185,GO:0046394,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051596,GO:0060255,GO:0061727,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1903506,GO:1990837,GO:2000112,GO:2001141		ko:K13631		M00647			ko00000,ko00002,ko03000				Escherichia	1QV3Z@1224,1T27F@1236,3XPPU@561,COG2207@1,COG2207@2	NA|NA|NA	K	Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters
b4063	155864.EDL933_5401	3.5e-82	310.8	Escherichia	soxR	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0044424,GO:0044464,GO:0048037,GO:0050896,GO:0051536,GO:0051537,GO:0051540		ko:K13639					ko00000,ko03000				Escherichia	1RH2U@1224,1S6M0@1236,3XM4P@561,COG0789@1,COG0789@2	NA|NA|NA	K	Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity
b4064	155864.EDL933_5403	3.4e-231	807.4	Escherichia	yjcD	GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823		ko:K06901					ko00000,ko02000	2.A.1.40			Escherichia	1MUV0@1224,1RMBE@1236,3XNSU@561,COG2252@1,COG2252@2	NA|NA|NA	S	High-affinity transporter for guanine and hypoxanthine
b4065	316407.85676817	3.5e-294	1016.9	Escherichia	yjcE	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042592,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098719,GO:0098739,GO:0098771,GO:0099516,GO:0099587,GO:1902600		ko:K03316					ko00000	2.A.36			Escherichia	1MW5T@1224,1RPH6@1236,3XN4E@561,COG0025@1,COG0025@2	NA|NA|NA	P	sodium ion import across plasma membrane
b4066	316407.85676818	7.8e-132	477.2	Gammaproteobacteria													Escherichia	1QGYJ@1224,1SJA2@1236,COG1357@1,COG1357@2	NA|NA|NA	S	Pentapeptide repeats (9 copies)
b4067	316407.85676819	2.8e-299	1033.9	Escherichia	actP	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006846,GO:0006847,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015123,GO:0015238,GO:0015318,GO:0015654,GO:0015698,GO:0015710,GO:0015711,GO:0015718,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035433,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K14393					ko00000,ko02000	2.A.21.7		iB21_1397.B21_03899,iECBD_1354.ECBD_3965,iECD_1391.ECD_03939	Escherichia	1MVJ8@1224,1RN0R@1236,3XMJ5@561,COG4147@1,COG4147@2	NA|NA|NA	P	Cation acetate symporter ActP
b4068	198214.SF4128	1.6e-51	208.4	Gammaproteobacteria													Escherichia	1MZF3@1224,1SCCK@1236,COG3162@1,COG3162@2	NA|NA|NA	S	Membrane
b4069	316407.85676821	0.0	1355.1	Escherichia	acs	GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006083,GO:0006464,GO:0006473,GO:0006476,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016405,GO:0016787,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017001,GO:0017144,GO:0018193,GO:0018205,GO:0018394,GO:0019213,GO:0019538,GO:0019752,GO:0032787,GO:0033558,GO:0034421,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043543,GO:0043687,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044267,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045733,GO:0046395,GO:0050218,GO:0071704,GO:0072329,GO:0098732,GO:0140096,GO:1901564,GO:1901575	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004			iE2348C_1286.E2348C_4392	Escherichia	1MUF5@1224,1RMNZ@1236,3XNZN@561,COG0365@1,COG0365@2	NA|NA|NA	F	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl- adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
b4070	155864.EDL933_5410	7.3e-288	995.7	Escherichia	nrfA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z5669	Escherichia	1MVJT@1224,1RQD1@1236,3XME8@561,COG3303@1,COG3303@2	NA|NA|NA	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
b4071	155864.EDL933_5411	4.1e-109	400.6	Escherichia	nrfB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016661,GO:0016662,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044237,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0097159,GO:0098809,GO:1901363		ko:K04013					ko00000			iAF1260.b4071,iB21_1397.B21_03903,iBWG_1329.BWG_3785,iE2348C_1286.E2348C_4394,iEC55989_1330.EC55989_4566,iECABU_c1320.ECABU_c46160,iECBD_1354.ECBD_3961,iECB_1328.ECB_03943,iECDH1ME8569_1439.ECDH1ME8569_3929,iECD_1391.ECD_03943,iECED1_1282.ECED1_4799,iECH74115_1262.ECH74115_5576,iECO111_1330.ECO111_4947,iECO26_1355.ECO26_5189,iECP_1309.ECP_4304,iECSE_1348.ECSE_4366,iECSP_1301.ECSP_5168,iECW_1372.ECW_m4437,iEKO11_1354.EKO11_4249,iETEC_1333.ETEC_4381,iEcDH1_1363.EcDH1_3921,iEcE24377_1341.EcE24377A_4627,iEcHS_1320.EcHS_A4316,iJO1366.b4071,iLF82_1304.LF82_1521,iNRG857_1313.NRG857_20390,iUMNK88_1353.UMNK88_4932,iWFL_1372.ECW_m4437,iY75_1357.Y75_RS21185	Escherichia	1R4W9@1224,1RR9K@1236,3XNIN@561,COG3303@1,COG3303@2	NA|NA|NA	C	Plays a role in nitrite reduction
b4072	155864.EDL933_5412	2.6e-131	474.6	Escherichia	nrfC	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0042279,GO:0055114,GO:0098809		ko:K04014					ko00000			iUMNK88_1353.UMNK88_4933	Escherichia	1NBNQ@1224,1RQJG@1236,3XMN4@561,COG0437@1,COG0437@2	NA|NA|NA	C	Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes
b4073	316407.85676825	2.8e-171	607.8	Escherichia	nrfD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K04015					ko00000			iAPECO1_1312.APECO1_2382,iE2348C_1286.E2348C_4396,iECABU_c1320.ECABU_c46180,iECOK1_1307.ECOK1_4578,iECP_1309.ECP_4306,iECS88_1305.ECS88_4566,iLF82_1304.LF82_1523,iNRG857_1313.NRG857_20400,iUMN146_1321.UM146_20560,iUTI89_1310.UTI89_C4663,ic_1306.c5069	Escherichia	1MXQ9@1224,1RQ22@1236,3XNMB@561,COG3301@1,COG3301@2	NA|NA|NA	P	Polysulphide reductase, NrfD
b4074	316407.85676826	0.0	1085.9	Escherichia	nrfE	GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901564		ko:K04016			R05712	RC00176	ko00000				Escherichia	1MUQS@1224,1T69C@1236,3XRJ2@561,COG1138@1,COG1138@2	NA|NA|NA	O	May be required for the biogenesis of c-type cytochromes
b4075	316407.85676827	9.2e-65	252.7	Escherichia	nrfF	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0065003,GO:0071704,GO:0071840,GO:1901564		ko:K04017					ko00000				Escherichia	1MZZ5@1224,1S9H1@1236,3XPSD@561,COG3088@1,COG3088@2	NA|NA|NA	P	Formate-dependent nitrite reductase complex subunit
b4076	316407.85676828	1.1e-101	375.9	Escherichia	nrfG	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0065003,GO:0071704,GO:0071840,GO:1901564		ko:K04018					ko00000				Escherichia	1PJQ5@1224,1S1PY@1236,3XM5C@561,COG4235@1,COG4235@2	NA|NA|NA	O	Required for formate-dependent nitrite reduction. Not required for the biosynthesis of any of the c-type cytochromes nor for the secretion of the periplasmic cytochromes
b4077	316407.85676829	3.1e-229	800.8	Escherichia	gltP	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0008150,GO:0015711,GO:0015849,GO:0016020,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702,GO:0071944		ko:K11102					ko00000,ko02000	2.A.23.1.1,2.A.23.1.2			Escherichia	1MU0Q@1224,1RMEN@1236,3XNKQ@561,COG1301@1,COG1301@2	NA|NA|NA	C	Catalyzes the proton-dependent transport of glutamate and aspartate
b4078	155864.EDL933_5419	6.9e-127	459.9	Escherichia	yjcO	GO:0003674,GO:0008047,GO:0008150,GO:0030234,GO:0043085,GO:0044093,GO:0050790,GO:0065007,GO:0065009,GO:0098772		ko:K07126					ko00000				Escherichia	1NEX5@1224,1RPRA@1236,3XNHQ@561,COG0790@1,COG0790@2	NA|NA|NA	S	enzyme activator activity
b4079	316407.85676831	0.0	1464.9	Escherichia	fdhF	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0015942,GO:0015944,GO:0016491,GO:0016651,GO:0016999,GO:0017144,GO:0019752,GO:0030151,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704	1.17.99.7	ko:K22015					ko00000,ko01000			iECBD_1354.ECBD_3953	Escherichia	1QTZB@1224,1T1JA@1236,3XN7Y@561,COG3383@1,COG3383@2	NA|NA|NA	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
b4080	316407.85676832	1.5e-267	928.3	Escherichia	mdtP	GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015893,GO:0015906,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0045117,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072348,GO:1901474,GO:1901682,GO:1902599		ko:K15550					ko00000,ko02000	1.B.17.3.9			Escherichia	1MUZZ@1224,1RQEP@1236,3XNZR@561,COG1538@1,COG1538@2	NA|NA|NA	MU	Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
b4081	316407.85676833	0.0	1334.3	Escherichia	mdtO	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015893,GO:0015906,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:1901474,GO:1901682,GO:1902599		ko:K15547					ko00000,ko02000	2.A.85.6.1			Escherichia	1R0HK@1224,1RQSH@1236,3XNXH@561,COG1289@1,COG1289@2	NA|NA|NA	U	Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
b4082	316407.85676834	2.5e-181	641.3	Escherichia	mdtN	GO:0003674,GO:0005215,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015893,GO:0015906,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0045117,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0072348,GO:1901474,GO:1901682,GO:1902599		ko:K15549					ko00000,ko02000	8.A.1.1.3			Escherichia	1MWG0@1224,1RP22@1236,3XMUQ@561,COG1566@1,COG1566@2	NA|NA|NA	V	Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
b4622	469008.B21_04514	1.1e-40	172.2	Escherichia	ytcA												Escherichia	1NIF0@1224,1SGEJ@1236,2DR7E@1,33AJ8@2,3XR32@561	NA|NA|NA	S	Uncharacterised protein family
b4083	316407.85676835	0.0	1332.8	Escherichia	yjcS	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006790,GO:0006805,GO:0008150,GO:0008152,GO:0008484,GO:0009410,GO:0009987,GO:0016787,GO:0016788,GO:0018741,GO:0018909,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043436,GO:0044237,GO:0044281,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071466,GO:0071704											Escherichia	1MU82@1224,1RMHR@1236,3XQEC@561,COG2015@1,COG2015@2	NA|NA|NA	Q	dodecyl sulfate metabolic process
b4084	469008.B21_03916	5e-181	640.2	Escherichia	alsK	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008787,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019313,GO:0019314,GO:0019316,GO:0019318,GO:0019320,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046367,GO:0046835,GO:0051156,GO:0071704,GO:1901135,GO:1901575	2.7.1.55	ko:K00881	ko00051,ko01120,map00051,map01120		R03576	RC00002,RC00017	ko00000,ko00001,ko01000			iECSF_1327.ECSF_3965,iLF82_1304.LF82_0079,iNRG857_1313.NRG857_20490,iY75_1357.Y75_RS21265	Escherichia	1R5PJ@1224,1RZZI@1236,3XQUS@561,COG1940@1,COG1940@2	NA|NA|NA	F	Catalyzes the phosphorylation of D-allose to D-allose 6- phosphate
b4085	316407.85676838	1e-130	472.6	Escherichia	alsE	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019313,GO:0019314,GO:0019316,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0034700,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046367,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575		ko:K17195	ko00051,ko01120,map00051,map01120		R09031	RC03111	ko00000,ko00001,ko01000			iEcSMS35_1347.EcSMS35_4551	Escherichia	1MX3K@1224,1RSAB@1236,3XQCQ@561,COG0036@1,COG0036@2	NA|NA|NA	G	Catalyzes the reversible epimerization of D-allulose 6- phosphate to D-fructose 6-phosphate. Can also catalyze with lower efficiency the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate
b4086	316407.85676839	1.4e-170	605.5	Escherichia	alsC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K10550	ko02010,map02010	M00217			ko00000,ko00001,ko00002,ko02000	3.A.1.2.6		iE2348C_1286.E2348C_4415,iECIAI39_1322.ECIAI39_4510,iEcSMS35_1347.EcSMS35_4552	Escherichia	1QHVT@1224,1RRYA@1236,3XQJI@561,COG1172@1,COG1172@2	NA|NA|NA	G	probably responsible for the translocation of the substrate across the membrane
b4087	316407.85676840	2.6e-291	1007.3	Escherichia	alsA	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.17	ko:K10551	ko02010,map02010	M00217			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.6		iECED1_1282.ECED1_4821,iECNA114_1301.ECNA114_4270	Escherichia	1MU22@1224,1RMCH@1236,3XQVS@561,COG1129@1,COG1129@2	NA|NA|NA	P	Part of the ABC transporter complex AlsBAC involved in D-allose import. Probably responsible for energy coupling to the transport system
b4088	316407.85676841	4.1e-167	594.0	Escherichia	alsB	GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K10549	ko02010,map02010	M00217			ko00000,ko00001,ko00002,ko02000	3.A.1.2.6		iECIAI39_1322.ECIAI39_4512,iECSF_1327.ECSF_3969,iNRG857_1313.NRG857_20510,iUMN146_1321.UM146_20675	Escherichia	1NP4K@1224,1SZUW@1236,3XQNK@561,COG1879@1,COG1879@2	NA|NA|NA	G	D-allose-binding periplasmic protein
b4089	1440052.EAKF1_ch1791	1e-162	579.3	Escherichia	rpiR	GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141											Escherichia	1MV3U@1224,1RYB0@1236,3XQCZ@561,COG1737@1,COG1737@2	NA|NA|NA	K	Regulatory protein involved in rpiB gene repression. Also involved in als operon repression
b4090	316407.85676843	5.9e-79	300.1	Escherichia	rpiB	GO:0003674,GO:0003824,GO:0004751,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008786,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019313,GO:0019314,GO:0019316,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046367,GO:0071704,GO:1901575	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000			iECABU_c1320.ECABU_c46440,ic_1306.c5096	Escherichia	1RHBF@1224,1S3FD@1236,3XQ0J@561,COG0698@1,COG0698@2	NA|NA|NA	G	isomerase B
b4487	199310.c5097	2.9e-27	127.9	Escherichia	yjdP												Escherichia	1MYKJ@1224,1S5WZ@1236,2B3A4@1,31VYC@2,3XQ1D@561	NA|NA|NA		
b4092	316407.85676845	1.5e-151	542.0	Gammaproteobacteria													Escherichia	1P9QI@1224,1RQPE@1236,COG1235@1,COG1235@2	NA|NA|NA	S	Carbon-phosphorus lyase complex accessory protein
b4093	316407.85676846	1.3e-78	298.9	Gammaproteobacteria													Escherichia	1QEZN@1224,1S4IF@1236,COG0454@1,COG0456@2	NA|NA|NA	K	Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role
b4094	316407.85676847	1.5e-100	372.1	Gammaproteobacteria													Escherichia	1RGXZ@1224,1S3VA@1236,COG3709@1,COG3709@2	NA|NA|NA	F	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
b4095	316407.85676848	1.4e-212	745.3	Gammaproteobacteria													Escherichia	1MV7H@1224,1RMR7@1236,COG3454@1,COG3454@2	NA|NA|NA	P	phosphonate metabolism protein PhnM
b4096	316407.85676849	3.5e-123	447.6	Gammaproteobacteria													Escherichia	1MUPB@1224,1RS1I@1236,COG4778@1,COG4778@2	NA|NA|NA	P	phosphonate C-P lyase system protein PhnL
b4097	316407.85676850	4.6e-140	503.8	Gammaproteobacteria													Escherichia	1MVRN@1224,1RR70@1236,COG4107@1,COG4107@2	NA|NA|NA	P	phosphonate C-P lyase system protein PhnK
b4098	316407.85676851	7.3e-163	579.7	Gammaproteobacteria													Escherichia	1MV7T@1224,1RNI7@1236,COG3627@1,COG3627@2	NA|NA|NA	H	Catalyzes the breakage of the C-P bond in alpha-D-ribose 1-methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose
b4099	316407.85676852	2.5e-200	704.5	Gammaproteobacteria													Escherichia	1MUBA@1224,1RRT5@1236,COG3626@1,COG3626@2	NA|NA|NA	P	Phosphonate
b4100	316407.85676853	3.4e-103	380.9	Escherichia	phnH	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0006793,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0019634,GO:0019637,GO:0019700,GO:0032991,GO:0042802,GO:0044237,GO:0046434,GO:0061694,GO:0061695,GO:0071704,GO:1901575,GO:1902494,GO:1904176,GO:1990234	2.7.8.37	ko:K06165	ko00440,map00440		R10185	RC00005,RC00063	ko00000,ko00001,ko01000				Escherichia	1RHXN@1224,1RZR8@1236,3XQ24@561,COG3625@1,COG3625@2	NA|NA|NA	P	Together with PhnG, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate
b4101	316407.85676854	1.9e-77	295.0	Gammaproteobacteria													Escherichia	1MZTZ@1224,1S3FT@1236,COG3624@1,COG3624@2	NA|NA|NA	P	Phosphonate C-P lyase system protein PhnG
b4102	316407.85676855	2.7e-129	468.0	Escherichia	phnF			ko:K02043					ko00000,ko03000				Escherichia	1Q856@1224,1RQ3N@1236,3XQWA@561,COG2188@1,COG2188@2	NA|NA|NA	K	Transcriptional regulator
b4583	469008.B21_03936	5.1e-84	317.8	Gammaproteobacteria													Escherichia	1MW4F@1224,1RQ3V@1236,COG3639@1,COG3639@2	NA|NA|NA	P	Phosphonate ABC transporter
b4105	316407.85676857	2.7e-188	664.5	Gammaproteobacteria													Escherichia	1MXD8@1224,1RR46@1236,COG3221@1,COG3221@2	NA|NA|NA	P	Phosphonate ABC transporter
b4106	316407.85676858	2.7e-143	514.6	Escherichia	phnC		3.6.3.28	ko:K02041	ko02010,map02010	M00223			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9			Escherichia	1MVE9@1224,1RRV7@1236,3XRIR@561,COG3638@1,COG3638@2	NA|NA|NA	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
b4107	316407.85676859	3.7e-81	307.4	Escherichia	phnB			ko:K04750					ko00000				Escherichia	1N0S4@1224,1S93U@1236,3XM9N@561,COG2764@1,COG2764@2	NA|NA|NA	S	3-demethylubiquinone-9 3-methyltransferase
b4108	155864.EDL933_5453	1.7e-59	235.0	Escherichia	phnA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K06193	ko01120,map01120				ko00000				Escherichia	1RGUU@1224,1S60W@1236,3XPRW@561,COG2824@1,COG2824@2	NA|NA|NA	P	PhnA Zinc-Ribbon
b4109	316407.85676861	0.0	1448.3	Escherichia	yjdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007059,GO:0008150,GO:0009987,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N3I9@1224,1RSA8@1236,3XMJU@561,COG0699@1,COG0699@2	NA|NA|NA	S	Important for the colocalization of sister nascent DNA strands after replication fork passage during DNA replication, and for positioning and subsequent partitioning of sister chromosomes. Does not have GTPase activity on its own
b4110	316407.85676862	7.8e-168	596.3	Escherichia	yjcZ												Escherichia	1PNJ3@1224,1T18N@1236,28MYC@1,2ZB58@2,3XRMT@561	NA|NA|NA	S	YjcZ-like protein
b4111	155864.EDL933_5456	5.5e-278	963.0	Escherichia	proP	GO:0003333,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0007231,GO:0008150,GO:0008324,GO:0008519,GO:0009628,GO:0009651,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015101,GO:0015199,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015651,GO:0015652,GO:0015653,GO:0015672,GO:0015695,GO:0015696,GO:0015697,GO:0015711,GO:0015804,GO:0015824,GO:0015838,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0023052,GO:0031224,GO:0031226,GO:0031460,GO:0033554,GO:0034220,GO:0035524,GO:0042538,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0065007,GO:0071214,GO:0071470,GO:0071472,GO:0071474,GO:0071475,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072349,GO:0072488,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098662,GO:0098739,GO:0104004,GO:1902600,GO:1903825,GO:1905039,GO:1905647		ko:K03762					ko00000,ko02000	2.A.1.6.4		iUTI89_1310.UTI89_C4705,ic_1306.c5116	Escherichia	1MU46@1224,1RNIM@1236,3XP07@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response
b4112	316407.85676864	1.7e-196	691.8	Escherichia	basS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0042221,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K07643	ko01503,ko02020,map01503,map02020	M00451,M00721,M00722			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1QTSX@1224,1RQMH@1236,3XNJ7@561,COG0642@1,COG0642@2	NA|NA|NA	T	Sensor protein basS
b4113	316407.85676865	1.4e-121	442.2	Escherichia	basR	GO:0000156,GO:0000160,GO:0003674,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K07771	ko01503,ko02020,map01503,map02020	M00451,M00721,M00722			ko00000,ko00001,ko00002,ko02022				Escherichia	1N0YI@1224,1RPNH@1236,3XNK2@561,COG0745@1,COG0745@2	NA|NA|NA	K	transcriptional regulatory protein
b4114	155864.EDL933_5459	0.0	1088.6	Escherichia	eptA	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016776,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.8.43	ko:K03760	ko01503,map01503	M00722	R11555,R11556,R11557	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005				Escherichia	1MWS7@1224,1RMNG@1236,3XMGY@561,COG2194@1,COG2194@2	NA|NA|NA	S	Catalyzes the addition of a phosphoethanolamine moiety to the lipid A. The phosphoethanolamine modification is required for resistance to polymyxin (By similarity)
b4115	155864.EDL933_5460	4.9e-246	856.7	Escherichia	adiC	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015174,GO:0015181,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015802,GO:0015809,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098771,GO:1903825,GO:1903826,GO:1905039,GO:1990822		ko:K03759					ko00000,ko02000	2.A.3.2		iECO26_1355.ECO26_5227	Escherichia	1MUA2@1224,1RRKS@1236,3XNHB@561,COG0531@1,COG0531@2	NA|NA|NA	E	Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach
b4116	316407.85676868	2.1e-140	505.0	Escherichia	adiY	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03755					ko00000,ko03000				Escherichia	1RBK1@1224,1S36K@1236,3XQP6@561,COG2207@1,COG2207@2	NA|NA|NA	K	regulatory protein
b4117	316407.85676869	0.0	1565.4	Escherichia	adiA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0006873,GO:0006885,GO:0008144,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019725,GO:0019752,GO:0019842,GO:0030003,GO:0030004,GO:0030170,GO:0030641,GO:0036094,GO:0042592,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0045852,GO:0046395,GO:0048037,GO:0048878,GO:0050662,GO:0050801,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:0098771,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.1.1.19	ko:K01584	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000			iEC042_1314.EC042_4483	Escherichia	1MWK4@1224,1RMVF@1236,3XNRQ@561,COG1982@1,COG1982@2	NA|NA|NA	E	Biodegradative arginine decarboxylase
b4118	199310.c5123	3.8e-173	614.0	Escherichia	melR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141											Escherichia	1R4BQ@1224,1RTAM@1236,3XQ6C@561,COG2169@1,COG2169@2	NA|NA|NA	K	Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site
b4119	316407.85676871	1.5e-271	941.4	Escherichia	melA	GO:0000166,GO:0003674,GO:0003824,GO:0004553,GO:0004557,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005994,GO:0005995,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0030145,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901575	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603		R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000			iECH74115_1262.ECH74115_5633,iECSP_1301.ECSP_5218,iECs_1301.ECs5101	Escherichia	1NI6G@1224,1RN45@1236,3XQ8R@561,COG1486@1,COG1486@2	NA|NA|NA	G	melibiose metabolic process
b4120	511145.b4120	3.4e-261	907.1	Escherichia	melB	GO:0003674,GO:0005215,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0008643,GO:0015075,GO:0015077,GO:0015081,GO:0015144,GO:0015154,GO:0015156,GO:0015157,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015487,GO:0015592,GO:0015672,GO:0015765,GO:0015766,GO:0015769,GO:0015772,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0035725,GO:0043887,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1901505,GO:1901656		ko:K11104					ko00000,ko02000	2.A.2.1		iBWG_1329.BWG_3833,iECDH10B_1368.ECDH10B_4312,iECDH1ME8569_1439.ECDH1ME8569_3979,iEKO11_1354.EKO11_4199,iEcDH1_1363.EcDH1_3872	Escherichia	1MVUM@1224,1RP5J@1236,3XQX4@561,COG2211@1,COG2211@2	NA|NA|NA	P	Responsible for melibiose and other galactoside transport. It is capable of using hydrogen, sodium, and lithium cations as coupling cations for cotransport, depending on the particular sugar transported (symport system)
b4121	316407.85676873	1.7e-111	408.7	Escherichia	yjdF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08984					ko00000				Escherichia	1N7NB@1224,1RS4F@1236,3XMPA@561,COG3647@1,COG3647@2	NA|NA|NA	S	Predicted membrane protein (DUF2238)
b4122	316407.85676874	0.0	1118.2	Escherichia	fumB	GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0033554,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0047808,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000				Escherichia	1MUV9@1224,1RN8U@1236,3XNXU@561,COG1838@1,COG1838@2,COG1951@1,COG1951@2	NA|NA|NA	C	Catalyzes the reversible hydration of fumarate to (S)- malate
b4123	198214.SF4100	1.9e-242	844.7	Gammaproteobacteria													Escherichia	1MVHH@1224,1RPTE@1236,COG2704@1,COG2704@2	NA|NA|NA	S	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
b4124	155864.EDL933_5470	8.4e-136	489.6	Escherichia	dcuR	GO:0000160,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K07703	ko02020,map02020	M00488			ko00000,ko00001,ko00002,ko02022				Escherichia	1MUC7@1224,1RNEF@1236,3XN3Z@561,COG4565@1,COG4565@2	NA|NA|NA	K	Member of the two-component regulatory system DcuR DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD
b4125	155864.EDL933_5471	3.3e-289	1000.3	Escherichia	dcuS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016020,GO:0016021,GO:0016043,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031326,GO:0035556,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051259,GO:0051260,GO:0051716,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141	2.7.13.3	ko:K07701	ko02020,map02020	M00488			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1MXQ5@1224,1RNRF@1236,3XMMT@561,COG3290@1,COG3290@2	NA|NA|NA	T	Member of the two-component regulatory system DcuR DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD
b4126	155864.EDL933_5473	1.2e-40	171.8	Escherichia	yjdI												Escherichia	1N10V@1224,1S95I@1236,3XQ06@561,COG3592@1,COG3592@2	NA|NA|NA	S	Divergent 4Fe-4S mono-cluster
b4127	316407.85676879	2.9e-44	184.1	Escherichia	yjdJ			ko:K06975					ko00000				Escherichia	1N6YS@1224,1S6I3@1236,3XPWS@561,COG2388@1,COG2388@2	NA|NA|NA	S	GCN5-related N-acetyl-transferase
b4559	637910.ROD_15891	1.5e-11	74.7	Citrobacter													Escherichia	1N8R7@1224,1SCPI@1236,2E4I9@1,32ZDC@2,3WYYE@544	NA|NA|NA	S	Toxin GhoT_OrtT
b4129	155864.EDL933_5477	1.3e-290	1005.0	Escherichia	lysU	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJO1366.b4129,iWFL_1372.ECW_m4490	Escherichia	1MX1V@1224,1RMJN@1236,3XQHS@561,COG1190@1,COG1190@2	NA|NA|NA	J	Belongs to the class-II aminoacyl-tRNA synthetase family
b4130	316407.85676883	8.2e-271	939.1	Escherichia	yjdL	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006857,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015333,GO:0015672,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0035442,GO:0035443,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042937,GO:0042938,GO:0042939,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904680		ko:K03305					ko00000	2.A.17		iEcSMS35_1347.EcSMS35_4599	Escherichia	1MW6W@1224,1RM8P@1236,3XN0T@561,COG3104@1,COG3104@2	NA|NA|NA	E	Proton-dependent permease that transports di- and tripeptides. Shows significantly higher specificity towards dipeptides than tripeptides. Has a preference for dipeptides with a C-terminal Lys residue. Can bind Ala-Lys, Lys-Ala, Ala-Ala. Can also transport alanine and trialanine
b4131	155864.EDL933_5479	0.0	1466.4	Escherichia	cadA	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006553,GO:0006554,GO:0006807,GO:0008150,GO:0008152,GO:0008923,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019001,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.1.1.18	ko:K01582	ko00310,ko00960,ko01100,ko01110,map00310,map00960,map01100,map01110		R00462	RC00299	ko00000,ko00001,ko01000				Escherichia	1MWK4@1224,1RMVF@1236,3XMCQ@561,COG1982@1,COG1982@2	NA|NA|NA	E	lysine decarboxylase
b4132	155864.EDL933_5480	1.1e-245	855.5	Escherichia	cadB	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0006950,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008519,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0015075,GO:0015077,GO:0015078,GO:0015101,GO:0015171,GO:0015174,GO:0015179,GO:0015189,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015297,GO:0015298,GO:0015318,GO:0015490,GO:0015491,GO:0015672,GO:0015695,GO:0015696,GO:0015711,GO:0015802,GO:0015807,GO:0015839,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0033554,GO:0034220,GO:0042221,GO:0042493,GO:0043872,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071214,GO:0071467,GO:0071468,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:0099516,GO:0104004,GO:1902022,GO:1902475,GO:1902600,GO:1903401,GO:1903825,GO:1905039,GO:1990451,GO:1990822		ko:K03757					ko00000,ko02000	2.A.3.2		iAF1260.b4132,iAPECO1_1312.APECO1_2321,iB21_1397.B21_03965,iBWG_1329.BWG_3846,iE2348C_1286.E2348C_4459,iEC042_1314.EC042_4498,iEC55989_1330.EC55989_4625,iECABU_c1320.ECABU_c46860,iECBD_1354.ECBD_3898,iECB_1328.ECB_04003,iECDH10B_1368.ECDH10B_4325,iECD_1391.ECD_04003,iECH74115_1262.ECH74115_5648,iECIAI1_1343.ECIAI1_4365,iECNA114_1301.ECNA114_4318,iECO103_1326.ECO103_4884,iECO26_1355.ECO26_5244,iECOK1_1307.ECOK1_4644,iECP_1309.ECP_4376,iECS88_1305.ECS88_4636,iECSE_1348.ECSE_4432,iECSF_1327.ECSF_4021,iECSP_1301.ECSP_5232,iECUMN_1333.ECUMN_4666,iECW_1372.ECW_m4493,iECs_1301.ECs5114,iEKO11_1354.EKO11_4186,iETEC_1333.ETEC_4443,iEcE24377_1341.EcE24377A_4687,iEcHS_1320.EcHS_A4373,iEcSMS35_1347.EcSMS35_4601,iEcolC_1368.EcolC_3895,iG2583_1286.G2583_4959,iJO1366.b4132,iJR904.b4132,iLF82_1304.LF82_0255,iNRG857_1313.NRG857_20730,iUMN146_1321.UM146_20900,iUMNK88_1353.UMNK88_4999,iUTI89_1310.UTI89_C4729,iWFL_1372.ECW_m4493,iY75_1357.Y75_RS21520,ic_1306.c5141	Escherichia	1MUA2@1224,1RRKS@1236,3XMNQ@561,COG0531@1,COG0531@2	NA|NA|NA	E	cadaverine lysine antiporter
b4133	316407.85676886	1.1e-294	1018.5	Escherichia	cadC	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K03765					ko00000,ko03000				Escherichia	1PYUK@1224,1SYU4@1236,3XP26@561,COG3710@1,COG3710@2	NA|NA|NA	K	transcriptional activator
b4135	199310.c5217	2.3e-104	384.8	Escherichia	yjdC	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141											Escherichia	1RAPB@1224,1RPSA@1236,3XMS0@561,COG1309@1,COG1309@2	NA|NA|NA	K	nucleic acid-templated transcription
b4136	316407.85676888	0.0	1113.2	Escherichia	dsbD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008152,GO:0009266,GO:0009628,GO:0009898,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016021,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0019725,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0042221,GO:0042493,GO:0042592,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0055114,GO:0065003,GO:0065007,GO:0065008,GO:0071502,GO:0071840,GO:0071944,GO:0098552,GO:0098562	1.8.1.8	ko:K04084					ko00000,ko01000,ko03110	5.A.1.1		iECSE_1348.ECSE_4435	Escherichia	1MU8W@1224,1RPF7@1236,3XMTA@561,COG4232@1,COG4232@2	NA|NA|NA	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps
b4137	155864.EDL933_5484	5.3e-56	223.4	Escherichia	cutA	GO:0003674,GO:0005488,GO:0005507,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0022607,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0065003,GO:0071840		ko:K03926					ko00000				Escherichia	1N6TN@1224,1SCFM@1236,3XPPZ@561,COG1324@1,COG1324@2	NA|NA|NA	P	Involved in resistance toward heavy metals
b4138	198214.SF4292	2.5e-226	791.2	Gammaproteobacteria													Escherichia	1MVHH@1224,1RPTE@1236,COG2704@1,COG2704@2	NA|NA|NA	S	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
b4139	155864.EDL933_5486	1.3e-273	948.3	Escherichia	aspA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008797,GO:0009058,GO:0009066,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100		R00490	RC00316,RC02799	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_2250,iECs_1301.ECs5120,iG2583_1286.G2583_4966,iSBO_1134.SBO_4317,iSDY_1059.SDY_4444,iSF_1195.SF4293,iSFxv_1172.SFxv_4682,iSSON_1240.SSON_4322,iS_1188.S4560,iUTI89_1310.UTI89_C4736,iZ_1308.Z5744,ic_1306.c5222	Escherichia	1R9JY@1224,1RP5Z@1236,3XP1Y@561,COG1027@1,COG1027@2	NA|NA|NA	E	Aspartate ammonia-lyase
b4140	316407.85676892	1.9e-67	261.9	Escherichia	fxsA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0044425,GO:0044464,GO:0071944		ko:K07113					ko00000				Escherichia	1MZJJ@1224,1S8XU@1236,3XPKI@561,COG3030@1,COG3030@2	NA|NA|NA	S	Suppressor of F exclusion of phage T7
b4141	316407.85676893	4.5e-233	813.5	Escherichia	yjeH	GO:0000099,GO:0000101,GO:0000102,GO:0001101,GO:0003333,GO:0003674,GO:0005215,GO:0005294,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015191,GO:0015238,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015821,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043200,GO:0043865,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:1901680,GO:1901682,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039		ko:K16263					ko00000,ko02000	2.A.3.13			Escherichia	1NCSX@1224,1RND7@1236,3XNCR@561,COG0531@1,COG0531@2	NA|NA|NA	E	L-methionine secondary active transmembrane transporter activity
b4142	1440052.EAKF1_ch1687c	3.1e-44	184.1	Escherichia	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220		ko:K04078					ko00000,ko03029,ko03110				Escherichia	1MZ2X@1224,1S8YR@1236,3XPUM@561,COG0234@1,COG0234@2	NA|NA|NA	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
b4143	155864.EDL933_5491	6e-286	989.6	Escherichia	groL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019058,GO:0019068,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0044183,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0061077,GO:0097159,GO:0097367,GO:0101031,GO:1901265,GO:1901363,GO:1990220		ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152				ko00000,ko00001,ko03019,ko03029,ko03110,ko04147				Escherichia	1MURR@1224,1RMTB@1236,3XN1I@561,COG0459@1,COG0459@2	NA|NA|NA	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
b4144	155864.EDL933_5492	2.7e-58	231.1	Escherichia	yjeI	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1RJBQ@1224,1S6CT@1236,2AGMU@1,316V4@2,3XPWY@561	NA|NA|NA	S	cellular response to DNA damage stimulus
b4145	316407.85676897	2.1e-157	561.6	Escherichia	yjeJ												Escherichia	1MWNU@1224,1S0I0@1236,28ICE@1,2Z8ET@2,3XNQ3@561	NA|NA|NA	S	YjeJ-like
b4146	316407.85676898	6.7e-195	686.4	Escherichia	JD73_27635	GO:0003674,GO:0003824,GO:0005488,GO:0016853,GO:0016866,GO:0016869,GO:0048037,GO:0051536,GO:0051539,GO:0051540		ko:K19810					ko00000,ko01000,ko03012			iECH74115_1262.ECH74115_5662,iECIAI39_1322.ECIAI39_4611,iS_1188.S4569	Escherichia	1MUPJ@1224,1RM84@1236,3XMWB@561,COG1509@1,COG1509@2	NA|NA|NA	C	With EpmA is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. EpmB appears to act before EpmA. Displays lysine 2,3-aminomutase activity, producing (R)-beta-lysine from (S)-alpha-lysine (L-lysine). Cannot use (S)-ornithine or (R)- alpha-lysine as a substrate
b4147	198214.SF4303	1.5e-103	382.1	Gammaproteobacteria													Escherichia	1MW2J@1224,1RPW7@1236,COG0231@1,COG0231@2	NA|NA|NA	J	Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation
b4410	155864.EDL933_5496	3.5e-13	79.7	Escherichia	ecnA			ko:K16347					ko00000,ko02000				Escherichia	1NGDA@1224,1SGAS@1236,3XQ58@561,COG5510@1,COG5510@2	NA|NA|NA	S	Entericidin EcnA/B family
b4411	155864.EDL933_5497	1.5e-15	87.8	Escherichia	ecnB			ko:K16348					ko00000,ko02000	9.B.13.1.1			Escherichia	1NH88@1224,1SGIK@1236,3XQ3I@561,COG5510@1,COG5510@2	NA|NA|NA	S	Entericidin EcnA/B family
b4148	1440052.EAKF1_ch1678c	7.2e-47	193.0	Escherichia	sugE	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944		ko:K11741					ko00000,ko02000	2.A.7.1			Escherichia	1MZ6P@1224,1S8TD@1236,3XPWE@561,COG2076@1,COG2076@2	NA|NA|NA	U	Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations
b4149	155864.EDL933_5499	2.1e-99	368.2	Escherichia	blc	GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0071944		ko:K03098					ko00000,ko04147				Escherichia	1RDAI@1224,1S3PW@1236,3XMI7@561,COG3040@1,COG3040@2	NA|NA|NA	M	Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids
b4150	316407.85676904	2.2e-223	781.2	Escherichia	ampC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008800,GO:0016787,GO:0016810,GO:0016812,GO:0042597,GO:0044464	3.5.2.6	ko:K01467	ko01501,ko02020,map01501,map02020	M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000				Escherichia	1MY01@1224,1RNUI@1236,3XNQH@561,COG1680@1,COG1680@2	NA|NA|NA	V	beta-lactamase
b4151	155864.EDL933_5501	4.4e-61	240.4	Escherichia	frdD	GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0008177,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016627,GO:0016635,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803		ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002			ic_1306.c5239	Escherichia	1RDZD@1224,1S3W5@1236,3XPPF@561,COG3080@1,COG3080@2	NA|NA|NA	C	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
b4152	155864.EDL933_5502	1.9e-68	265.0	Escherichia	frdC	GO:0000104,GO:0001539,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006996,GO:0008150,GO:0008152,GO:0008177,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016635,GO:0022607,GO:0030030,GO:0030031,GO:0032991,GO:0040011,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048870,GO:0051179,GO:0051674,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071973,GO:0097588,GO:0098796,GO:0098797,GO:0098803		ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002				Escherichia	1RD34@1224,1S419@1236,3XPS9@561,COG3029@1,COG3029@2	NA|NA|NA	C	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
b4153	1440052.EAKF1_ch1673	1.5e-143	515.4	Escherichia	frdB	GO:0000104,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0040011,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0051179,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0051674,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071973,GO:0097588,GO:0098796,GO:0098797,GO:0098803	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_4397	Escherichia	1MVHS@1224,1RNWR@1236,3XMXG@561,COG0479@1,COG0479@2	NA|NA|NA	C	the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth
b4154	316407.85676908	0.0	1222.2	Escherichia	frdA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_4621,iEcSMS35_1347.EcSMS35_4625	Escherichia	1MU5M@1224,1RMU2@1236,3XP24@561,COG1053@1,COG1053@2	NA|NA|NA	C	fumarate reductase, flavoprotein subunit
b4155	155864.EDL933_5505	2.7e-185	654.4	Escherichia	epmA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016755,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0052868,GO:0071704,GO:0071915,GO:0072580,GO:0072581,GO:0140096,GO:1901564		ko:K04568					ko00000,ko01000,ko03012				Escherichia	1MU97@1224,1RMR9@1236,3XP5E@561,COG2269@1,COG2269@2	NA|NA|NA	J	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)- beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon- amino group of EF-P 'Lys-34'
b4156	316407.85676910	3.4e-280	970.3	Escherichia	yjeM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1R5N5@1224,1RR4J@1236,3XNY9@561,COG0531@1,COG0531@2	NA|NA|NA	P	transmembrane transporter activity
b4157	316407.85676911	1.3e-53	215.3	Escherichia	yjeN												Escherichia	1NZ1P@1224,1SI9F@1236,2F8BX@1,340QY@2,3XPWW@561	NA|NA|NA		
b4158	316407.85676912	1.9e-55	221.5	Escherichia	yjeO	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1NEFT@1224,1SDVY@1236,2E7B5@1,331UJ@2,3XPV3@561	NA|NA|NA	S	Protein of unknown function (DUF2645)
b4159	316407.85676913	0.0	2006.1	Escherichia	yjeP			ko:K22051					ko00000,ko02000	1.A.23.1.2,1.A.23.1.3			Escherichia	1MWSA@1224,1RMYY@1236,3XNQQ@561,COG1511@1,COG1511@2,COG3264@1,COG3264@2	NA|NA|NA	M	Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Gates spontaneously in response to increased membrane tension
b4160	155864.EDL933_5508	6.6e-184	649.8	Escherichia	psd	GO:0003674,GO:0003824,GO:0004609,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0071704,GO:0090407,GO:1901576	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_4379,iECSF_1327.ECSF_4049	Escherichia	1MVT4@1224,1RN1U@1236,3XNZ3@561,COG0688@1,COG0688@2	NA|NA|NA	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
b4161	316407.85676915	4.2e-200	703.7	Escherichia	rsgA	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022613,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0036094,GO:0042254,GO:0042274,GO:0043167,GO:0043168,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100		R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009			iAF1260.b4161,iBWG_1329.BWG_3876,iECDH10B_1368.ECDH10B_4356,iECDH1ME8569_1439.ECDH1ME8569_4021,iEKO11_1354.EKO11_4148,iEcDH1_1363.EcDH1_3829,iEcolC_1368.EcolC_3849,iJO1366.b4161,iUMNK88_1353.UMNK88_5099,iY75_1357.Y75_RS21675	Escherichia	1MUEF@1224,1RMMB@1236,3XN8J@561,COG1162@1,COG1162@2	NA|NA|NA	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit
b4162	199310.c5249	2.5e-100	371.3	Escherichia	orn	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K13288	ko03008,map03008				ko00000,ko00001,ko01000,ko03009,ko03019				Escherichia	1R9WX@1224,1S217@1236,3XMZQ@561,COG1949@1,COG1949@2	NA|NA|NA	A	3'-to-5' exoribonuclease specific for small oligoribonucleotides
b4166	316407.85676917	1.1e-225	788.9	Escherichia	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979					ko00000,ko01000,ko03016				Escherichia	1MV1H@1224,1RMD9@1236,3XP23@561,COG1600@1,COG1600@2	NA|NA|NA	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
b4167	316407.85676918	2.4e-297	1027.3	Escherichia	nnrD	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759					ko00000,ko01000				Escherichia	1MU1Q@1224,1RMPS@1236,3XMRN@561,COG0062@1,COG0062@2,COG0063@1,COG0063@2	NA|NA|NA	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
b4168	198214.SF4323	3.1e-83	314.3	Gammaproteobacteria													Escherichia	1RGYU@1224,1S6IB@1236,COG0802@1,COG0802@2	NA|NA|NA	S	ATPase or kinase
b4169	316407.85676920	6.2e-241	839.7	Escherichia	amiB	GO:0000003,GO:0000910,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0008745,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019954,GO:0022402,GO:0022414,GO:0030288,GO:0030313,GO:0031975,GO:0032505,GO:0042597,GO:0043093,GO:0044464,GO:0051301,GO:0061783	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036			iG2583_1286.G2583_4996	Escherichia	1MUQK@1224,1RMP1@1236,3XN8B@561,COG0860@1,COG0860@2	NA|NA|NA	M	N-acetylmuramoyl-L-alanine amidase
b4170	316407.85676921	0.0	1206.8	Escherichia	mutL	GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391		ko:K03572	ko03430,map03430				ko00000,ko00001,ko03400				Escherichia	1MV61@1224,1RM89@1236,3XN0H@561,COG0323@1,COG0323@2	NA|NA|NA	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of
b4171	316407.85676922	2.2e-176	624.8	Escherichia	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110		R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016				Escherichia	1MUB2@1224,1RMDU@1236,3XMXU@561,COG0324@1,COG0324@2	NA|NA|NA	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
b4172	1005994.GTGU_02041	1.3e-29	135.6	Gammaproteobacteria													Escherichia	1MZM1@1224,1S8W0@1236,COG1923@1,COG1923@2	NA|NA|NA	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
b4173	316407.85676924	2.3e-237	827.8	Escherichia	hflX	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112		ko:K03665					ko00000,ko03009				Escherichia	1MUA0@1224,1RN7V@1236,3XMWA@561,COG2262@1,COG2262@2	NA|NA|NA	J	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
b4174	155864.EDL933_5519	1.3e-179	636.0	Escherichia	hflK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071944,GO:0098552,GO:0098796		ko:K04088		M00742			ko00000,ko00002,ko01000				Escherichia	1MUM2@1224,1RMUG@1236,3XNW0@561,COG0330@1,COG0330@2	NA|NA|NA	O	HflC and HflK could encode or regulate a protease
b4175	155864.EDL933_5520	7.8e-164	583.2	Escherichia	hflC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0044092,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071944,GO:0098552,GO:0098796		ko:K04087		M00742			ko00000,ko00002,ko01000				Escherichia	1MV7R@1224,1RM8Z@1236,3XM38@561,COG0330@1,COG0330@2	NA|NA|NA	O	HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda. HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins
b4176	155864.EDL933_5521	1.6e-28	131.3	Escherichia	yjeT			ko:K09937					ko00000				Escherichia	1N6V7@1224,1SCHT@1236,3XQ4U@561,COG3242@1,COG3242@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2065)
b4177	155864.EDL933_5522	9.3e-250	869.0	Escherichia	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000			iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063	Escherichia	1MU5B@1224,1RNEW@1236,3XNIR@561,COG0104@1,COG0104@2	NA|NA|NA	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
b4178	1440052.EAKF1_ch1651c	6.6e-72	276.6	Escherichia	nsrR	GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141		ko:K13771	ko05132,map05132				ko00000,ko00001,ko03000				Escherichia	1N05H@1224,1S8SJ@1236,3XMZ9@561,COG1959@1,COG1959@2	NA|NA|NA	K	Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity
b4179	316407.85676930	0.0	1550.4	Escherichia	rnr	GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575		ko:K12573	ko03018,map03018				ko00000,ko00001,ko01000,ko03016,ko03019				Escherichia	1MUS6@1224,1RMQE@1236,3XNPR@561,COG0557@1,COG0557@2	NA|NA|NA	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs
b4180	198214.SF4335	5.8e-132	476.9	Gammaproteobacteria													Escherichia	1MWCM@1224,1RN2F@1236,COG0566@1,COG0566@2	NA|NA|NA	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA
b4181	155864.EDL933_5526	5.1e-66	256.9	Escherichia	yjfI			ko:K09980					ko00000				Escherichia	1MYU4@1224,1S7KT@1236,3XRAQ@561,COG3789@1,COG3789@2	NA|NA|NA	S	Uncharacterized protein conserved in bacteria (DUF2170)
b4182	199310.c5266	1.3e-109	402.5	Escherichia	yjfJ	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464											Escherichia	1R41V@1224,1RPJ9@1236,3XQUU@561,COG1842@1,COG1842@2	NA|NA|NA	KT	identical protein binding
b4183	316407.85676934	2.1e-125	454.9	Escherichia	yjfK												Escherichia	1MV1M@1224,1RZDJ@1236,28M4V@1,2ZAIQ@2,3XQQF@561	NA|NA|NA	S	Protein of unknown function (DUF2491)
b4184	155864.EDL933_5529	3.3e-65	254.2	Escherichia	yjfL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K08989					ko00000				Escherichia	1N14W@1224,1S3T5@1236,3XQYP@561,COG3766@1,COG3766@2	NA|NA|NA	S	Domain of Unknown Function (DUF350)
b4185	316407.85676936	9.8e-120	436.0	Escherichia	yjfM												Escherichia	1R90S@1224,1RZWI@1236,3XQJC@561,COG5463@1,COG5463@2	NA|NA|NA	S	Protein of unknown function (DUF1190)
b4186	316407.85676937	1.1e-236	825.5	Gammaproteobacteria													Escherichia	1MW6V@1224,1RQAP@1236,COG0754@1,COG0754@2	NA|NA|NA	E	Glutathionylspermidine synthase
b4187	316407.85676938	0.0	1104.7	Escherichia	aidB	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K09456					ko00000				Escherichia	1MU20@1224,1RN7X@1236,3XP17@561,COG1960@1,COG1960@2	NA|NA|NA	I	Part of the adaptive DNA-repair response to alkylating agents. Could prevent alkylation damage by protecting DNA and destroying alkylating agents that have yet to reach their DNA target. Binds to double-stranded DNA with a preference for a DNA region that includes its own promoter. Shows weak isovaleryl-CoA dehydrogenase activity in vitro
b4188	155864.EDL933_5533	9.3e-43	179.1	Escherichia	yjfN												Escherichia	1N2WZ@1224,1S96B@1236,2DMK5@1,32S43@2,3XQ2Y@561	NA|NA|NA	S	Protein of unknown function (DUF1471)
b4189	316407.85676940	5.9e-52	209.9	Escherichia	bsmA	GO:0000302,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0009636,GO:0009987,GO:0010035,GO:0033554,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044764,GO:0046677,GO:0050896,GO:0051704,GO:0051716,GO:1901700											Escherichia	1NBPH@1224,1SDYX@1236,3XPYU@561,COG3650@1,COG3650@2	NA|NA|NA	S	response to hydrogen peroxide
b4190	316407.85676941	7e-141	506.5	Escherichia	yjfP	GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0034338,GO:0052689		ko:K06889					ko00000				Escherichia	1NVFB@1224,1RYJ3@1236,3XMCA@561,COG1073@1,COG1073@2	NA|NA|NA	S	short-chain carboxylesterase activity
b4191	155864.EDL933_5536	2e-135	488.4	Escherichia	ulaR	GO:0003674,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019842,GO:0030246,GO:0031406,GO:0031418,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0048029,GO:0048037,GO:0050662,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K03477					ko00000,ko03000				Escherichia	1QM4U@1224,1RNN2@1236,3XNF0@561,COG1349@1,COG1349@2	NA|NA|NA	K	Represses ulaG and the ulaABCDEF operon
b4192	155864.EDL933_5537	7.7e-218	762.7	Escherichia	ulaG	GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009056,GO:0009109,GO:0009111,GO:0009987,GO:0016052,GO:0016054,GO:0016787,GO:0016788,GO:0019752,GO:0019852,GO:0019854,GO:0030145,GO:0035460,GO:0042365,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046872,GO:0046914,GO:0051186,GO:0051187,GO:0052689,GO:0071704,GO:1901575		ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2200,iUTI89_1310.UTI89_C4792,ic_1306.c5280	Escherichia	1N50Z@1224,1RRU3@1236,3XMMB@561,COG2220@1,COG2220@2	NA|NA|NA	S	Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions
b4193	316407.85676944	1.1e-256	892.1	Escherichia	ulaA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015711,GO:0015749,GO:0015849,GO:0015882,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035461,GO:0042802,GO:0044464,GO:0046942,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090585,GO:0098656,GO:1903825,GO:1905039		ko:K03475	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.7.1		iB21_1397.B21_04022,iEC55989_1330.EC55989_4750,iECBD_1354.ECBD_3841,iECB_1328.ECB_04060,iECD_1391.ECD_04060,iECIAI1_1343.ECIAI1_4426,iECO111_1330.ECO111_5021,iETEC_1333.ETEC_4539,iEcSMS35_1347.EcSMS35_4664	Escherichia	1MWNR@1224,1RP9S@1236,3XME4@561,COG3037@1,COG3037@2	NA|NA|NA	S	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport
b4194	1440052.EAKF1_ch1635c	8.7e-50	202.6	Escherichia	ulaB	GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015711,GO:0015749,GO:0015849,GO:0015882,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035461,GO:0046942,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051234,GO:0055085,GO:0071702,GO:0090563,GO:0090585,GO:0098656,GO:1903825,GO:1905039	2.7.1.194	ko:K02822	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1		iSDY_1059.SDY_4363	Escherichia	1RET1@1224,1S47F@1236,3XPPQ@561,COG3414@1,COG3414@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport
b4195	155864.EDL933_5540	6.5e-81	306.6	Escherichia	ulaC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015711,GO:0015749,GO:0015849,GO:0015882,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035461,GO:0044464,GO:0046942,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090585,GO:0098656,GO:1903825,GO:1905039	2.7.1.194	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1		iAF1260.b4195,iBWG_1329.BWG_3907,iECABU_c1320.ECABU_c47530,iECDH10B_1368.ECDH10B_4390,iECDH1ME8569_1439.ECDH1ME8569_4052,iECH74115_1262.ECH74115_5711,iECSP_1301.ECSP_5295,iECUMN_1333.ECUMN_4728,iECs_1301.ECs5171,iEcDH1_1363.EcDH1_3798,iEcSMS35_1347.EcSMS35_4666,iG2583_1286.G2583_5022,iJO1366.b4195,iSbBS512_1146.SbBS512_E4725,iY75_1357.Y75_RS21845,iZ_1308.Z5804,ic_1306.c5284	Escherichia	1R4YX@1224,1RTCG@1236,3XMNX@561,COG1762@1,COG1762@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport
b4196	316407.85676947	1.1e-118	432.6	Escherichia	ulaD	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009056,GO:0009109,GO:0009111,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0019852,GO:0019854,GO:0033982,GO:0042365,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046872,GO:0051186,GO:0051187,GO:0071704,GO:1901575	4.1.1.85	ko:K03078	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R07125	RC01721	ko00000,ko00001,ko00002,ko01000			iAF1260.b4196,iAPECO1_1312.APECO1_2196,iBWG_1329.BWG_3908,iE2348C_1286.E2348C_4519,iECDH10B_1368.ECDH10B_4391,iECDH1ME8569_1439.ECDH1ME8569_4053,iECED1_1282.ECED1_4983,iECIAI1_1343.ECIAI1_4429,iECNA114_1301.ECNA114_4412,iECOK1_1307.ECOK1_4710,iECP_1309.ECP_4441,iECS88_1305.ECS88_4782,iECSE_1348.ECSE_4494,iECSF_1327.ECSF_4082,iEcDH1_1363.EcDH1_3797,iJO1366.b4196,iJR904.b4196,iLF82_1304.LF82_2375,iNRG857_1313.NRG857_21325,iUMN146_1321.UM146_21220,iY75_1357.Y75_RS21850	Escherichia	1QWE4@1224,1RPV5@1236,3XM54@561,COG0269@1,COG0269@2	NA|NA|NA	F	Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization
b4197	316407.85676948	1.4e-161	575.5	Escherichia	ulaE	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016857,GO:0019752,GO:0019852,GO:0034015,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0051186,GO:0071704	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000			iEcSMS35_1347.EcSMS35_4668	Escherichia	1MWTD@1224,1RPT6@1236,3XNDK@561,COG3623@1,COG3623@2	NA|NA|NA	G	Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization
b4198	316407.85676949	2.7e-131	474.6	Escherichia	ulaF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0008270,GO:0008742,GO:0009056,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019752,GO:0019852,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:1901575	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000			iSDY_1059.SDY_4367	Escherichia	1MU54@1224,1RMIP@1236,3XM68@561,COG0235@1,COG0235@2	NA|NA|NA	G	Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization
b4199	155864.EDL933_5544	3.2e-43	180.6	Escherichia	yjfY												Escherichia	1N0ER@1224,1SA4Y@1236,2CSU0@1,32SRX@2,3XQ14@561	NA|NA|NA	S	Protein of unknown function (DUF1471)
b4200	1440052.EAKF1_ch1628c	7.8e-67	259.6	Escherichia	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0097159,GO:1901363,GO:1990904		ko:K02990	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011,ko03029				Escherichia	1RH82@1224,1S5VU@1236,3XPK6@561,COG0360@1,COG0360@2	NA|NA|NA	J	Binds together with S18 to 16S ribosomal RNA
b4201	316407.85676952	4.6e-54	216.9	Escherichia	priB	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006276,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990077,GO:1990099		ko:K02686	ko03440,map03440				ko00000,ko00001,ko03400				Escherichia	1RHIE@1224,1S6H5@1236,3XPXW@561,COG2965@1,COG2965@2	NA|NA|NA	L	Binds single-stranded DNA at the primosome assembly site (PAS). During primosome assembly it facilitates the complex formation between PriA and DnaT
b4202	1005994.GTGU_02012	2.2e-34	151.0	Gammaproteobacteria													Escherichia	1MZ8U@1224,1S8R8@1236,COG0238@1,COG0238@2	NA|NA|NA	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
b4203	1440052.EAKF1_ch1626c	2e-71	275.0	Escherichia	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904		ko:K02939	ko03010,map03010	M00178			br01610,ko00000,ko00001,ko00002,ko03011				Escherichia	1RD0R@1224,1S3WS@1236,3XMY6@561,COG0359@1,COG0359@2	NA|NA|NA	J	Binds to the 23S rRNA
b4204	511145.b4204	2e-154	551.6	Escherichia													Escherichia	1NQYJ@1224,1SM8F@1236,2F0KM@1,33TP9@2,3XQXP@561	NA|NA|NA	S	Protein of unknown function (DUF2686)
b4205	481805.EcolC_3801	1.8e-71	275.0	Escherichia													Escherichia	1R5AI@1224,1S6BI@1236,3XPXB@561,COG1309@1,COG1309@2	NA|NA|NA	K	Bacterial regulatory proteins, tetR family
b4206	316407.85676957	3e-116	424.5	Escherichia	ytfB			ko:K07269					ko00000				Escherichia	1R4XK@1224,1S430@1236,3XPK0@561,COG3061@1,COG3061@2	NA|NA|NA	M	Opacity-associated protein A N-terminal motif
b4207	155864.EDL933_5553	1.8e-110	405.2	Escherichia	fklB	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005527,GO:0005528,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042597,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:0140096,GO:1901363,GO:1901564	5.2.1.8	ko:K03773					ko00000,ko01000,ko03110				Escherichia	1RDA1@1224,1RPMP@1236,3XMCG@561,COG0545@1,COG0545@2	NA|NA|NA	O	peptidyl-prolyl cis-trans isomerase
b4208	155864.EDL933_5554	2.4e-259	901.0	Escherichia	cycA	GO:0001761,GO:0001762,GO:0003333,GO:0003674,GO:0005215,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015180,GO:0015187,GO:0015238,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015808,GO:0015816,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0022858,GO:0022889,GO:0032328,GO:0032329,GO:0034220,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0042940,GO:0042941,GO:0042942,GO:0042943,GO:0042944,GO:0042945,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039		ko:K11737					ko00000,ko02000	2.A.3.1.7		iECO111_1330.ECO111_5093,iECO26_1355.ECO26_5376,iEcHS_1320.EcHS_A4458,iSbBS512_1146.SbBS512_E4749	Escherichia	1MUPS@1224,1RPFT@1236,3XMYN@561,COG1113@1,COG1113@2	NA|NA|NA	E	Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine
b4209	198214.SF4277	1.1e-121	442.6	Gammaproteobacteria													Escherichia	1MVCQ@1224,1RPY6@1236,COG2846@1,COG2846@2	NA|NA|NA	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters
b4210	316407.85676961	9.8e-180	636.0	Escherichia	ytfF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MW7P@1224,1RQ9F@1236,3XMIQ@561,COG0697@1,COG0697@2	NA|NA|NA	EG	EamA-like transporter family
b4211	316407.85676962	1.1e-150	539.3	Escherichia	qorB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.6.5.2	ko:K19267	ko00130,ko01110,map00130,map01110		R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000				Escherichia	1MW44@1224,1RPD9@1236,3XMZ3@561,COG0702@1,COG0702@2	NA|NA|NA	GM	Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth
b4212	155864.EDL933_5558	1e-63	249.2	Escherichia	ytfH												Escherichia	1MZ6N@1224,1S5WB@1236,3XPSJ@561,COG1733@1,COG1733@2	NA|NA|NA	K	nucleic acid-templated transcription
b4213	316407.85676964	0.0	1305.0	Escherichia	cpdB	GO:0003674,GO:0003824,GO:0004112,GO:0005575,GO:0005623,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008252,GO:0008254,GO:0008663,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240		R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000			iEC55989_1330.EC55989_4773,iECH74115_1262.ECH74115_5730,iECNA114_1301.ECNA114_4436,iECSP_1301.ECSP_5315,iECW_1372.ECW_m4577,iECs_1301.ECs5191,iEKO11_1354.EKO11_4095,iEcE24377_1341.EcE24377A_4783,iG2583_1286.G2583_5043,iWFL_1372.ECW_m4577,iZ_1308.Z5824	Escherichia	1MU11@1224,1RMQV@1236,3XNBH@561,COG0737@1,COG0737@2	NA|NA|NA	F	Belongs to the 5'-nucleotidase family
b4214	316407.85676965	9.6e-143	512.7	Escherichia	cysQ	GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130		R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016			iAPECO1_1312.APECO1_2172,iE2348C_1286.E2348C_4545,iEC042_1314.EC042_4695,iEC55989_1330.EC55989_4774,iECABU_c1320.ECABU_c47840,iECIAI1_1343.ECIAI1_4448,iECIAI39_1322.ECIAI39_4686,iECO103_1326.ECO103_5013,iECO111_1330.ECO111_5101,iECO26_1355.ECO26_5384,iECOK1_1307.ECOK1_4735,iECP_1309.ECP_4468,iECSE_1348.ECSE_4520,iECSF_1327.ECSF_4108,iECUMN_1333.ECUMN_4751,iECW_1372.ECW_m4578,iEKO11_1354.EKO11_4094,iEcE24377_1341.EcE24377A_4785,iEcHS_1320.EcHS_A4468,iEcSMS35_1347.EcSMS35_4694,iLF82_1304.LF82_0422,iNRG857_1313.NRG857_21455,iSBO_1134.SBO_4229,iSDY_1059.SDY_4385,iSSON_1240.SSON_4399,iSbBS512_1146.SbBS512_E4758,iUMN146_1321.UM146_21355,iUTI89_1310.UTI89_C4823,iWFL_1372.ECW_m4578,ic_1306.c5313	Escherichia	1N0GY@1224,1RP5A@1236,3XNJQ@561,COG1218@1,COG1218@2	NA|NA|NA	P	Belongs to the inositol monophosphatase superfamily. CysQ family
b4215	316407.85676966	2e-177	628.2	Gammaproteobacteria													Escherichia	1NS1T@1224,1SJTN@1236,2EYVH@1,33S2K@2	NA|NA|NA		
b4216	316407.85676967	3.2e-98	364.4	Escherichia	ytfJ			ko:K07109					ko00000				Escherichia	1REC3@1224,1S3X5@1236,3XP2K@561,COG3054@1,COG3054@2	NA|NA|NA	S	Bacterial protein of unknown function (YtfJ_HI0045)
b4217	155864.EDL933_5563	2e-29	134.4	Escherichia	ytfK												Escherichia	1MZ8V@1224,1S908@1236,2CTIP@1,32STK@2,3XQ29@561	NA|NA|NA	S	Protein of unknown function (DUF1107)
b4218	155864.EDL933_5564	2.4e-224	784.6	Escherichia	ytfL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MV3P@1224,1T1MS@1236,3XNSD@561,COG1253@1,COG1253@2	NA|NA|NA	P	inner membrane protein YtfL
b4219	198214.SF4268	2.3e-124	451.4	Gammaproteobacteria													Escherichia	1MVUS@1224,1RNWU@1236,COG0225@1,COG0225@2	NA|NA|NA	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
b4220	155864.EDL933_5568	0.0	1182.9	Escherichia	ytfM	GO:0002790,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045203,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347		ko:K07278					ko00000,ko02000	1.B.33.2.4			Escherichia	1MUKM@1224,1RNQ3@1236,3XMQX@561,COG0729@1,COG0729@2	NA|NA|NA	M	Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane
b4221	316407.85676972	0.0	2487.2	Escherichia	ytfN	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347		ko:K09800					ko00000,ko02000				Escherichia	1MUVD@1224,1RMMF@1236,3XPEG@561,COG2911@1,COG2911@2	NA|NA|NA	S	Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. In reconstituted TAM this subunit (Ag43, AC P39180) is not necessary for substrate penetration in the outer membrane. Substrate binding to TamA moves its POTRA domains about 30 Angstroms into the periplasm, which would deform either the outer membrane or TamB and may provide force to reset TAM
b4222	198214.SF4265	2.2e-62	244.6	Gammaproteobacteria													Escherichia	1RH3X@1224,1S68T@1236,COG2105@1,COG2105@2	NA|NA|NA	S	AIG2 family
b4224	316407.85676975	5.1e-40	169.9	Gammaproteobacteria													Escherichia	1NHRR@1224,1SFWR@1236,COG2336@1,COG2336@2	NA|NA|NA	K	Antitoxin component of a type II toxin-antitoxin (TA) system. May be involved in the regulation of cell growth. It acts as a suppressor of the endoribonuclease (inhibitory function) of ChpB protein. Both ChpS and ChpB probably bind to the promoter region of the chpS-chpB operon to autoregulate their synthesis
b4225	316407.85676976	1.7e-57	228.4	Gammaproteobacteria													Escherichia	1RH4Z@1224,1S4NQ@1236,COG2337@1,COG2337@2	NA|NA|NA	T	Toxic component of a toxin-antitoxin (TA) module
b4226	155864.EDL933_5573	1.5e-97	362.1	Escherichia	ppa	GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008270,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050355	3.6.1.1	ko:K01507	ko00190,map00190				ko00000,ko00001,ko01000				Escherichia	1RA2F@1224,1RPVD@1236,3XM55@561,COG0221@1,COG0221@2	NA|NA|NA	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
b4227	316407.85676978	1.1e-172	612.5	Escherichia	ytfQ	GO:0003674,GO:0005215,GO:0005488,GO:0005534,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0015144,GO:0015145,GO:0015749,GO:0015757,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944		ko:K02058		M00221			ko00000,ko00002,ko02000	3.A.1.2		iECH74115_1262.ECH74115_5745,iECSP_1301.ECSP_5328,iECs_1301.ECs5205,iG2583_1286.G2583_5057,iSSON_1240.SSON_4409,iZ_1308.Z5838	Escherichia	1MXJS@1224,1RRZV@1236,3XNEE@561,COG1879@1,COG1879@2	NA|NA|NA	G	galactose binding
b4485	316407.85676979	3.1e-281	973.8	Escherichia	ytfR		3.6.3.17	ko:K02056		M00221			ko00000,ko00002,ko01000,ko02000	3.A.1.2		iECED1_1282.ECED1_5085	Escherichia	1MU22@1224,1RMCH@1236,3XMNV@561,COG1129@1,COG1129@2	NA|NA|NA	P	ABC transporter, ATP-binding protein
b4230	511145.b4230	3.5e-175	620.9	Escherichia	ytfT	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02057		M00221			ko00000,ko00002,ko02000	3.A.1.2		iECH74115_1262.ECH74115_5749,iUTI89_1310.UTI89_C4834,ic_1306.c5327	Escherichia	1MUM6@1224,1RRCX@1236,3XMG1@561,COG1172@1,COG1172@2	NA|NA|NA	G	Belongs to the binding-protein-dependent transport system permease family
b4231	316407.85676981	3.7e-174	617.5	Escherichia	yjfF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944		ko:K02057		M00221			ko00000,ko00002,ko02000	3.A.1.2		iECW_1372.ECW_m4592,iEKO11_1354.EKO11_4080,iWFL_1372.ECW_m4592	Escherichia	1MW9Z@1224,1RQ77@1236,3XMEW@561,COG1172@1,COG1172@2	NA|NA|NA	G	ABC transporter permease protein YjfF
b4232	198214.SF4258	2.6e-191	674.5	Gammaproteobacteria													Escherichia	1MW0E@1224,1RNFF@1236,COG0158@1,COG0158@2	NA|NA|NA	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
b4233	316407.85676983	6.3e-273	946.0	Escherichia	mpl	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464	6.3.2.45	ko:K02558					ko00000,ko01000			iSDY_1059.SDY_4251	Escherichia	1MUC5@1224,1RMMT@1236,3XNY8@561,COG0773@1,COG0773@2	NA|NA|NA	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate
b4234	155864.EDL933_5581	1.2e-94	352.4	Escherichia	yjgA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K09889					ko00000,ko03009				Escherichia	1MZ4R@1224,1S9JJ@1236,3XN2N@561,COG3028@1,COG3028@2	NA|NA|NA	S	UPF0307 protein YjgA
b4235	155864.EDL933_5582	7.6e-255	885.9	Escherichia	pmbA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564		ko:K03592					ko00000,ko01002				Escherichia	1MUVW@1224,1RPJF@1236,3XMDW@561,COG0312@1,COG0312@2	NA|NA|NA	S	Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA)
b4237	155864.EDL933_5584	2.6e-90	337.8	Escherichia	nrdG	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0015949,GO:0031250,GO:0032991,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:1901360	1.97.1.4	ko:K04068			R04710		ko00000,ko01000			iE2348C_1286.E2348C_4563	Escherichia	1RA7S@1224,1S20X@1236,3XNWN@561,COG0602@1,COG0602@2	NA|NA|NA	O	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
b4238	316407.85676987	0.0	1463.4	Escherichia	nrdD	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008998,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019001,GO:0019103,GO:0019438,GO:0019637,GO:0019692,GO:0030554,GO:0031250,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032556,GO:0032558,GO:0032559,GO:0032560,GO:0032564,GO:0032567,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046385,GO:0046483,GO:0046872,GO:0046914,GO:0051065,GO:0055086,GO:0055114,GO:0071704,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000			iECIAI39_1322.ECIAI39_4713	Escherichia	1MWMS@1224,1RNHS@1236,3XP9C@561,COG1328@1,COG1328@2	NA|NA|NA	F	anaerobic ribonucleoside-triphosphate reductase
b4239	316407.85676988	0.0	1190.3	Escherichia	treC	GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008788,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0033554,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071704,GO:1901575	3.2.1.93	ko:K01226	ko00500,map00500		R00837,R06113	RC00049	ko00000,ko00001,ko01000		GH13	iECW_1372.ECW_m4600,iEKO11_1354.EKO11_4072,iEcE24377_1341.EcE24377A_4811,iEcSMS35_1347.EcSMS35_4720,iWFL_1372.ECW_m4600	Escherichia	1MVKX@1224,1RMSH@1236,3XMPX@561,COG0366@1,COG0366@2	NA|NA|NA	G	Hydrolyzes trehalose-6-phosphate to glucose and glucose 6-phosphate. Can also very effectively hydrolyzes p-nitrophenyl- alpha-D-glucopyranoside, but it does not recognize trehalose, sucrose, maltose, isomaltose, or maltodextrins
b4240	316407.85676989	1.7e-265	921.4	Escherichia	treB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015766,GO:0015771,GO:0015772,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090589	2.7.1.201	ko:K02818,ko:K02819	ko00500,ko02060,map00500,map02060	M00270	R02780	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.2.13,4.A.1.2.4,4.A.1.2.8		iECABU_c1320.ECABU_c48060,ic_1306.c5339	Escherichia	1MVVJ@1224,1RMYB@1236,3XM3T@561,COG1263@1,COG1263@2,COG1264@1,COG1264@2	NA|NA|NA	G	PTS system, trehalose-specific
b4241	316407.85676990	1.2e-174	619.0	Escherichia	treR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141		ko:K03485					ko00000,ko03000				Escherichia	1QQPR@1224,1RRC9@1236,3XN38@561,COG1609@1,COG1609@2	NA|NA|NA	K	repressor
b4242	155864.EDL933_5592	0.0	1755.0	Escherichia	mgtA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0099131,GO:0099132	3.6.3.2	ko:K01531					ko00000,ko01000	3.A.3.4		iSF_1195.SF4248	Escherichia	1MUU5@1224,1RMYC@1236,3XNGR@561,COG0474@1,COG0474@2	NA|NA|NA	P	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily
b4243	155864.EDL933_5593	6.7e-63	246.5	Escherichia	ridA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009636,GO:0016787,GO:0019239,GO:0042221,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051082	3.5.99.10	ko:K09022			R11098,R11099	RC03275,RC03354	ko00000,ko01000				Escherichia	1MZ3J@1224,1S5XS@1236,3XPKX@561,COG0251@1,COG0251@2	NA|NA|NA	J	Accelerates the release of ammonia from reactive enamine imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities. Involved in the isoleucine biosynthesis (By similarity)
b4244	155864.EDL933_5594	1e-81	309.3	Escherichia	pyrI	GO:0003674,GO:0005488,GO:0008270,GO:0043167,GO:0043169,GO:0046872,GO:0046914		ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002				Escherichia	1RB7J@1224,1S2BM@1236,3XNQ2@561,COG1781@1,COG1781@2	NA|NA|NA	F	Involved in allosteric regulation of aspartate carbamoyltransferase
b4245	155864.EDL933_5595	6.6e-173	613.2	Escherichia	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z5856	Escherichia	1MWAB@1224,1RPSV@1236,3XMRZ@561,COG0540@1,COG0540@2	NA|NA|NA	F	Belongs to the ATCase OTCase family
b4246	199310.c5502	3.5e-19	99.8	Gammaproteobacteria													Escherichia	1NKR5@1224,1SGCH@1236,2EIE0@1,33C5D@2	NA|NA|NA	F	operon leader peptide
b4248	316407.85676996	3.1e-71	274.2	Escherichia	yjgH												Escherichia	1RCX5@1224,1S478@1236,3XPQT@561,COG0251@1,COG0251@2	NA|NA|NA	J	Endoribonuclease L-PSP
b4249	316407.85676997	1.6e-118	432.2	Escherichia	yjgI	GO:0000166,GO:0003674,GO:0005488,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0035438,GO:0036094,GO:0042710,GO:0043167,GO:0043168,GO:0044010,GO:0044764,GO:0048037,GO:0050661,GO:0050662,GO:0051704,GO:0070402,GO:0097159,GO:0097367,GO:1901265,GO:1901363		ko:K19336					ko00000				Escherichia	1N4J7@1224,1RQ0S@1236,3XRI8@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	Increases biofilm dispersal. Acts by binding directly to the signaling molecule cyclic-di-GMP, which decreases the intracellular concentration of cyclic-di-GMP and leads to biofilm dispersal. Also controls other biofilm-related phenotypes such as cell motility, cell size, cell aggregation and production of extracellular DNA and extracellular polysaccharides (EPS). Does not act as a phosphodiesterase
b4251	316407.85676998	5.2e-107	393.7	Gammaproteobacteria													Escherichia	1RC4X@1224,1S20B@1236,COG1309@1,COG1309@2	NA|NA|NA	K	tetR family
b4252	198214.SF4239	4.4e-82	310.5	Gammaproteobacteria													Escherichia	1RA6C@1224,1S281@1236,COG2731@1,COG2731@2	NA|NA|NA	G	Toxin-antitoxin biofilm protein TabA
b4253	316407.85677000	6.2e-276	956.4	Escherichia	yjgL												Escherichia	1QIG4@1224,1TGAH@1236,2AUX4@1,31KKI@2,3XQ8V@561	NA|NA|NA		
b4254	316407.85677001	2.4e-189	667.9	Escherichia	argI	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000			iECS88_1305.ECS88_4841	Escherichia	1MUFM@1224,1RQ59@1236,3XM2U@561,COG0078@1,COG0078@2	NA|NA|NA	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
b4255	155864.EDL933_5604	2.7e-70	271.2	Escherichia	rraB	GO:0003674,GO:0004857,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008428,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0019219,GO:0019222,GO:0019439,GO:0019899,GO:0030234,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0034641,GO:0034655,GO:0043086,GO:0043170,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065007,GO:0065009,GO:0071704,GO:0080090,GO:0090304,GO:0098772,GO:1901360,GO:1901361,GO:1901575		ko:K09893					ko00000,ko03019				Escherichia	1RDKS@1224,1S4A6@1236,3XPME@561,COG3076@1,COG3076@2	NA|NA|NA	S	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
b4256	316407.85677003	8.9e-92	342.8	Escherichia	yjgM			ko:K03828					ko00000,ko01000				Escherichia	1RAJC@1224,1S1YW@1236,3XRN5@561,COG0454@1,COG0456@2	NA|NA|NA	K	transferase activity, transferring acyl groups
b4257	316407.85677004	2.7e-219	767.7	Escherichia	yjgN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MW5P@1224,1RY3G@1236,3XP5Y@561,COG4269@1,COG4269@2	NA|NA|NA	S	Bacterial protein of unknown function (DUF898)
b4258	316407.85677005	0.0	1908.3	Escherichia	valS	GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016			iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iZ_1308.Z5870	Escherichia	1MV7B@1224,1RNEB@1236,3XMYC@561,COG0525@1,COG0525@2	NA|NA|NA	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
b4259	316407.85677006	1e-78	299.3	Escherichia	holC	GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Escherichia	1MZ3V@1224,1S94K@1236,3XN75@561,COG2927@1,COG2927@2	NA|NA|NA	L	Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
b4260	155864.EDL933_5609	2.8e-290	1003.8	Escherichia	pepA	GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042150,GO:0043170,GO:0043171,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100		R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002				Escherichia	1MUF9@1224,1RNM1@1236,3XNPE@561,COG0260@1,COG0260@2	NA|NA|NA	E	involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
b4261	198214.SF4228	1.9e-195	688.3	Gammaproteobacteria													Escherichia	1MUF2@1224,1RMN5@1236,COG0795@1,COG0795@2	NA|NA|NA	S	Permease
b4262	155864.EDL933_5612	4.4e-197	693.7	Escherichia	lptG	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0033036,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1902494,GO:1902495,GO:1904949,GO:1990351		ko:K11720	ko02010,map02010	M00320			ko00000,ko00001,ko00002,ko02000	1.B.42.1		iSSON_1240.SSON_4447	Escherichia	1MVW3@1224,1RM8H@1236,3XP68@561,COG0795@1,COG0795@2	NA|NA|NA	S	Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane
b4263	316407.85677010	7.9e-285	985.7	Escherichia	yjgR			ko:K06915					ko00000				Escherichia	1MU59@1224,1RPYD@1236,3XP0R@561,COG0433@1,COG0433@2	NA|NA|NA	S	Type IV secretion-system coupling protein DNA-binding domain
b4264	316407.85677011	1.5e-186	658.7	Escherichia	idnR			ko:K06146					ko00000,ko03000				Escherichia	1MUEP@1224,1RN0U@1236,3XRJ0@561,COG1609@1,COG1609@2	NA|NA|NA	K	Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate
b4265	316407.85677012	4.4e-231	807.0	Escherichia	idnT	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015128,GO:0015144,GO:0015318,GO:0015568,GO:0015711,GO:0015718,GO:0015726,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0035429,GO:0042873,GO:0042879,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K06157					ko00000,ko02000	2.A.8.1.2			Escherichia	1MUFG@1224,1RNGE@1236,3XNJE@561,COG2610@1,COG2610@2	NA|NA|NA	P	gluconate transporter
b4266	199310.c5367	5.4e-141	506.9	Escherichia	idnO	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008874,GO:0008875,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019520,GO:0019523,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046183,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.69	ko:K00046					ko00000,ko01000			iECIAI39_1322.ECIAI39_4739	Escherichia	1MWB6@1224,1RMZB@1236,3XQYG@561,COG1028@1,COG1028@2	NA|NA|NA	IQ	Catalyzes the reduction of 5-keto-D-gluconate to D- gluconate, using either NADH or NADPH. Is likely involved in an L- idonate degradation pathway that allows E.coli to utilize L- idonate as the sole carbon and energy source. Is also able to catalyze the reverse reaction in vitro, but the D-gluconate oxidation by the enzyme can only proceed with NAD
b4267	316407.85677014	2.7e-199	701.0	Gammaproteobacteria													Escherichia	1MV9A@1224,1RPYN@1236,COG1063@1,COG1063@2	NA|NA|NA	E	L-idonate 5-dehydrogenase
b4268	316407.85677015	8.2e-102	376.3	Escherichia	idnK	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019520,GO:0019521,GO:0019523,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046183,GO:0046316,GO:0046395,GO:0071704,GO:0072329,GO:1901575	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200		R01737	RC00002,RC00017	ko00000,ko00001,ko01000			iECSF_1327.ECSF_4156	Escherichia	1RHD0@1224,1S2UE@1236,3XRI9@561,COG3265@1,COG3265@2	NA|NA|NA	F	gluconokinase activity
b4269	316407.85677016	1.9e-197	694.9	Escherichia	yjgB	GO:0003674,GO:0003824,GO:0004033,GO:0005488,GO:0008106,GO:0008150,GO:0008152,GO:0008270,GO:0016491,GO:0016614,GO:0016616,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114		ko:K12957					ko00000,ko01000				Escherichia	1MUTT@1224,1RN4D@1236,3XMS3@561,COG1064@1,COG1064@2	NA|NA|NA	C	Catalyzes the reduction of a wide range of aldehydes including aliphatic fatty aldehydes (C4-C16), into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use glyceraldehyde or a ketone as substrate. Is a relevant source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of Ahr has yet to be determined
b4271	316407.85677017	4.8e-229	800.0	Escherichia	intB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1MU23@1224,1RMJ1@1236,3XN9B@561,COG0582@1,COG0582@2	NA|NA|NA	L	Belongs to the 'phage' integrase family
b4272	1440052.EAKF1_ch0283	7.2e-59	233.0	Escherichia													Escherichia	1N0V0@1224,1S7WV@1236,3XRHH@561,COG2963@1,COG2963@2	NA|NA|NA	L	transposase activity
b4273	316407.2447044	3.9e-178	630.6	Gammaproteobacteria													Escherichia	1MY62@1224,1RQSR@1236,COG2801@1,COG2801@2	NA|NA|NA	L	cog cog2801
b4575	362663.ECP_4524	1.1e-28	134.4	Escherichia													Escherichia	1NHRY@1224,1RS8R@1236,3XPEH@561,COG2194@1,COG2194@2	NA|NA|NA	S	sulfuric ester hydrolase activity
b4277	316407.85677021	6.5e-59	233.0	Bacteria													Escherichia	2CITE@1,33CXM@2	NA|NA|NA	S	IS66 C-terminal element
b4278	316407.85677022	2.7e-260	904.0	Escherichia	insG			ko:K07495					ko00000				Escherichia	1MVRM@1224,1RRFT@1236,3XQXI@561,COG3385@1,COG3385@2	NA|NA|NA	L	Transposase insG for insertion sequence element IS4
b4279	316407.85677023	4.2e-228	797.0	Escherichia	yjhB	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015318,GO:0015711,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039											Escherichia	1MWKH@1224,1RNW6@1236,3XRHB@561,COG0477@1,COG2814@2	NA|NA|NA	P	carboxylic acid transmembrane transporter activity
b4280	316407.85677024	1.5e-219	768.5	Gammaproteobacteria													Escherichia	1PE4Q@1224,1S1B3@1236,COG0673@1,COG0673@2	NA|NA|NA	S	cellular response to DNA damage stimulus
b4281	469008.B21_04107	1.4e-39	168.3	Gammaproteobacteria													Escherichia	1MZFK@1224,1SC2A@1236,2DZIS@1,32VBS@2	NA|NA|NA	S	Surface-adhesin protein E
b4282	469008.B21_04108	1.4e-37	161.8	Gammaproteobacteria													Escherichia	1MVPS@1224,1S0GA@1236,COG2271@1,COG2271@2	NA|NA|NA	G	Major Facilitator Superfamily
b4623	316407.85677025	3.2e-37	160.6	Gammaproteobacteria													Escherichia	1N10J@1224,1S994@1236,COG2963@1,COG2963@2	NA|NA|NA	L	Transposase IS3 IS911 family protein
b4284	316407.1742285	3.7e-218	763.8	Escherichia	insI3	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363											Escherichia	1PP49@1224,1RN7B@1236,3XQB0@561,COG2826@1,COG2826@2	NA|NA|NA	L	Transposase insI for insertion sequence element
b4286	316407.85677027	8.5e-59	232.6	Gammaproteobacteria													Escherichia	1R5ZM@1224,1RRBZ@1236,COG2085@1,COG2085@2	NA|NA|NA	S	NADP oxidoreductase coenzyme F420-dependent
b4287	316407.85677028	1.1e-141	509.2	Escherichia	fecE	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.34	ko:K02013	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14			Escherichia	1MUNG@1224,1RRII@1236,3XMZN@561,COG1120@1,COG1120@2	NA|NA|NA	P	Probably responsible for energy coupling to the transport system
b4288	316407.85677029	1.4e-170	605.5	Escherichia	fecD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015603,GO:0015688,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:1901678		ko:K02015	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14		iB21_1397.B21_04117,iEC042_1314.EC042_4777,iEC55989_1330.EC55989_4961,iECABU_c1320.ECABU_c49000,iECBD_1354.ECBD_3750,iECB_1328.ECB_04154,iECD_1391.ECD_04154,iECED1_1282.ECED1_5153,iECNA114_1301.ECNA114_2547,iECO26_1355.ECO26_5456,iEcE24377_1341.EcE24377A_4865,iEcolC_1368.EcolC_0740,iUMNK88_1353.UMNK88_5227	Escherichia	1MV9W@1224,1RR9X@1236,3XRJS@561,COG0609@1,COG0609@2	NA|NA|NA	P	Part of the binding-protein-dependent transport system for citrate-dependent Fe(3 ). Probably responsible for the translocation of the substrate across the membrane
b4289	316407.85677030	1.3e-174	619.0	Escherichia	fecC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015603,GO:0015688,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:1901678		ko:K02015	ko02010,map02010	M00240			ko00000,ko00001,ko00002,ko02000	3.A.1.14		iEC55989_1330.EC55989_4962,iECIAI39_1322.ECIAI39_4767,iEcE24377_1341.EcE24377A_4866	Escherichia	1R87A@1224,1RP2K@1236,3XRJT@561,COG0609@1,COG0609@2	NA|NA|NA	P	Part of the binding-protein-dependent transport system for citrate-dependent Fe(3 ). Probably responsible for the translocation of the substrate across the membrane
b4290	316407.85677031	5.1e-162	577.0	Gammaproteobacteria													Escherichia	1R3VS@1224,1RMCX@1236,COG4594@1,COG4594@2	NA|NA|NA	P	Part of the ABC transporter involved in the uptake of citrate-dependent Fe(3
b4291	316407.85677032	0.0	1584.3	Gammaproteobacteria													Escherichia	1MWDG@1224,1RQA5@1236,COG4772@1,COG4772@2	NA|NA|NA	P	receptor
b4292	316407.85677033	9.1e-178	629.4	Gammaproteobacteria													Escherichia	1N28G@1224,1RR9M@1236,COG3712@1,COG3712@2	NA|NA|NA	PT	Fe2 -dicitrate sensor, membrane component
b4293	316407.85677034	2.3e-90	338.2	Gammaproteobacteria													Escherichia	1RHRW@1224,1SYGZ@1236,COG1595@1,COG1595@2	NA|NA|NA	K	Belongs to the sigma-70 factor family. ECF subfamily
b4294	155864.EDL933_1099	1.2e-45	188.7	Gammaproteobacteria													Escherichia	1RIB2@1224,1S61N@1236,COG3677@1,COG3677@2	NA|NA|NA	L	cog cog3677
b4295	316407.85677036	1.1e-183	649.0	Gammaproteobacteria													Escherichia	1R558@1224,1S0CH@1236,COG2390@1,COG2390@2	NA|NA|NA	K	carbohydrate binding
b4296	316407.85677037	1.6e-220	771.9	Escherichia	yjhF	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015128,GO:0015144,GO:0015318,GO:0015711,GO:0015718,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0035429,GO:0042873,GO:0042879,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039		ko:K03299					ko00000,ko02000	2.A.8			Escherichia	1MUFG@1224,1RNGE@1236,3XNJE@561,COG2610@1,COG2610@2	NA|NA|NA	P	gluconate transporter
b4297	316407.85677038	0.0	1313.9	Escherichia	yjhG	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019520,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0050401,GO:0071704,GO:0072329,GO:1901575	4.2.1.82	ko:K22396	ko00040,map00040		R02429	RC00543	ko00000,ko00001,ko01000				Escherichia	1R4QF@1224,1RPTZ@1236,3XRJM@561,COG0129@1,COG0129@2	NA|NA|NA	E	Catalyzes the dehydration of D-xylonic acid to form 2- dehydro-3-deoxy-D-pentonate
b4298	316407.85677039	5.1e-170	603.6	Escherichia	yjhH	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019520,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0047440,GO:0071704,GO:0072329,GO:1901575	4.1.2.28	ko:K22397	ko00040,map00040		R01782	RC00307,RC00572	ko00000,ko00001,ko01000				Escherichia	1MXI1@1224,1RPXI@1236,3XQAY@561,COG0329@1,COG0329@2	NA|NA|NA	EM	Catalyze the formation of 2-keto-3-deoxy-gluconate (KDG) from pyruvate and glyceraldehyde. May also function as a 2-dehydro-3-deoxy-D-pentonate aldolase. Overexpression leads to increased growth (over 2 hours) in the presence of the antibiotics norfloxacin, ampicillin and streptomycin
b4299	316407.85677040	5.6e-149	533.5	Escherichia	yjhI	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141											Escherichia	1R3KG@1224,1S144@1236,3XRJX@561,COG1414@1,COG1414@2	NA|NA|NA	K	negative regulation of nucleic acid-templated transcription
b4300	316407.85677041	1.5e-146	525.4	Gammaproteobacteria													Escherichia	1R689@1224,1RYBN@1236,COG1349@1,COG1349@2	NA|NA|NA	K	transcriptional regulator
b4301	316407.85677042	1.6e-117	428.7	Gammaproteobacteria													Escherichia	1RA8C@1224,1S224@1236,COG0036@1,COG0036@2	NA|NA|NA	G	ribulose-phosphate 3-epimerase activity
b4302	316407.85677043	2.2e-78	298.1	Gammaproteobacteria													Escherichia	1RKN3@1224,1S73Z@1236,COG1762@1,COG1762@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane
b4303	316407.85677044	1.9e-152	545.0	Gammaproteobacteria													Escherichia	1Q83B@1224,1RYMH@1236,COG0434@1,COG0434@2	NA|NA|NA	S	BtpA family
b4304	316407.85677045	5.5e-234	816.6	Escherichia	sgcC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015791,GO:0015796,GO:0015850,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090584		ko:K02775	ko00052,ko01100,ko02060,map00052,map01100,map02060	M00279	R05570	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.5.1			Escherichia	1MVRC@1224,1RQ76@1236,3XR17@561,COG3775@1,COG3775@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
b4565	316407.85677046	2.9e-44	184.1	Gammaproteobacteria													Escherichia	1RKWM@1224,1S6WB@1236,COG3414@1,COG3414@2	NA|NA|NA	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane
b4305	316407.85677047	2.9e-215	754.2	Escherichia	sgcX			ko:K20609					ko00000,ko01000,ko01002				Escherichia	1MXEU@1224,1RYRZ@1236,3XN5P@561,COG1363@1,COG1363@2	NA|NA|NA	G	Has a broad aminopeptidase activity on non-blocked peptides by progressively cleaving amino acids off the peptide substrate. Aminopeptidase activity stops at the residue before the first proline in the peptide. Cannot cleave when proline is the first N-terminal residue
b4306	316407.85677048	2.5e-143	514.6	Gammaproteobacteria													Escherichia	1MXAK@1224,1RSIH@1236,COG2519@1,COG2519@2	NA|NA|NA	J	Methyl-transferase
b4307	316407.85677049	4.6e-102	377.1	Gammaproteobacteria													Escherichia	1RHPP@1224,1RYJS@1236,COG3153@1,COG3153@2	NA|NA|NA	S	transferase activity, transferring acyl groups
b4566	316407.85677050	2.6e-39	167.5	Gammaproteobacteria													Escherichia	1N7N0@1224,1SB6I@1236,COG3811@1,COG3811@2	NA|NA|NA	S	Belongs to the UPF0386 family
b4657	1140001.I571_02391	2.1e-14	84.7	Enterococcaceae													Escherichia	1V78E@1239,4B4FS@81852,4HX8N@91061,COG1670@1,COG1670@2	NA|NA|NA	J	FR47-like protein
b4308	316407.85677051	6.2e-193	679.9	Gammaproteobacteria													Escherichia	1N8SW@1224,1S05Y@1236,COG1112@1,COG1112@2,COG1502@1,COG1502@2	NA|NA|NA	L	PLD-like domain
b4309	316407.85677052	6.6e-200	703.0	Escherichia	nanS	GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044281,GO:0071704		ko:K22111					ko00000				Escherichia	1QWCB@1224,1T2TM@1236,2DDQI@1,2ZIWU@2,3XRN6@561	NA|NA|NA	S	Probably catalyzes the hydrolysis of the 9-O-acetyl group of 9-O-acetyl-N-acetylneuraminate (Neu5,9Ac2). Is required for growth of E.coli on Neu5,9Ac2, an alternative sialic acid commonly found in mammalian host mucosal sites, in particular in the human intestine
b4310	316407.85677053	1.7e-215	755.0	Escherichia	nanM	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0016853,GO:0016854,GO:0016857,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	5.1.3.24	ko:K17948					ko00000,ko01000				Escherichia	1PJCX@1224,1RS0N@1236,3XNS6@561,COG3055@1,COG3055@2	NA|NA|NA	M	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
b4311	316407.85677054	1.1e-140	505.8	Escherichia	nanC	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0008643,GO:0009279,GO:0015075,GO:0015136,GO:0015144,GO:0015157,GO:0015267,GO:0015288,GO:0015318,GO:0015478,GO:0015711,GO:0015739,GO:0015772,GO:0015849,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0034219,GO:0034220,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1901264,GO:1901505,GO:1903825,GO:1905039		ko:K22110					ko00000,ko02000	1.B.35.1,1.B.35.2		ic_1306.c5389	Escherichia	1RKI2@1224,1S6AC@1236,3XQDI@561,COG1452@1,COG1452@2	NA|NA|NA	M	Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria
b4312	155864.EDL933_5647	9e-115	419.5	Escherichia	fimB	GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0015074,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360		ko:K07357					ko00000				Escherichia	1QUDQ@1224,1T1V1@1236,3XPS4@561,COG0582@1,COG0582@2	NA|NA|NA	K	FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches fimA on
b4313	198214.SF4209	6.6e-110	403.3	Gammaproteobacteria													Escherichia	1R585@1224,1RZIC@1236,COG4974@1,COG4974@2	NA|NA|NA	K	FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off
b4314	316407.85677057	2.5e-87	328.2	Escherichia	fimA	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0022610,GO:0042802,GO:0042995,GO:0044464		ko:K07345	ko05133,map05133				ko00000,ko00001,ko02035,ko02044				Escherichia	1QI7Y@1224,1S07V@1236,3XMUH@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs
b4315	316407.85677058	6.2e-99	366.7	Escherichia	fimI	GO:0008150,GO:0009297,GO:0009987,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0043711,GO:0044085,GO:0071840		ko:K07351					ko00000,ko02035				Escherichia	1R7X9@1224,1RYWH@1236,3XM9U@561,COG3539@1,COG3539@2	NA|NA|NA	NU	pilus assembly
b4316	316407.85677059	3.1e-130	471.1	Escherichia	fimC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044183,GO:0044464,GO:0061077		ko:K07346					ko00000,ko02035,ko02044,ko03110				Escherichia	1R3T9@1224,1RS56@1236,3XNMT@561,COG3121@1,COG3121@2	NA|NA|NA	NU	Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH
b4317	316407.85677060	0.0	1776.1	Escherichia	fimD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944		ko:K07347	ko05133,map05133				ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3			Escherichia	1MUHE@1224,1RMPU@1236,3XMHU@561,COG3188@1,COG3188@2	NA|NA|NA	NU	Outer membrane usher protein fimD
b4318	316407.85677061	3.8e-93	347.4	Escherichia	fimF	GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464		ko:K07348					ko00000,ko02035,ko02044				Escherichia	1R6J8@1224,1S138@1236,3XN73@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae
b4319	316407.85677062	5.2e-84	317.0	Escherichia	fimG	GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464		ko:K07349					ko00000,ko02035,ko02044				Escherichia	1RC12@1224,1S36F@1236,3XPI2@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae
b4320	316407.85677063	8.9e-167	592.8	Escherichia	fimH	GO:0003674,GO:0005488,GO:0005537,GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0018995,GO:0022610,GO:0030246,GO:0033643,GO:0033644,GO:0036094,GO:0042995,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044464,GO:0048029		ko:K07350					ko00000,ko02035,ko02044				Escherichia	1NQXE@1224,1RQSD@1236,3XQAD@561,COG3539@1,COG3539@2	NA|NA|NA	NU	Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed
b4321	155864.EDL933_5656	1.1e-232	812.4	Escherichia	gntP	GO:0003674,GO:0005215,GO:0005342,GO:0005351,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008028,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015077,GO:0015078,GO:0015128,GO:0015144,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015711,GO:0015718,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0035429,GO:0042873,GO:0042879,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902600,GO:1903825,GO:1905039		ko:K16321					ko00000,ko02000	2.A.8.1.3			Escherichia	1MVK2@1224,1RZUF@1236,3XQH8@561,COG2610@1,COG2610@2	NA|NA|NA	P	High-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides, and some hexoses, but not glucose
b4322	316407.85677065	2.3e-231	807.7	Escherichia	uxuA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008198,GO:0008927,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019585,GO:0019752,GO:0030145,GO:0032787,GO:0033554,GO:0042839,GO:0042840,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0072329,GO:1901575	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000			iECED1_1282.ECED1_5204	Escherichia	1MWYD@1224,1RR0Q@1236,3XNJN@561,COG1312@1,COG1312@2	NA|NA|NA	G	Catalyzes the dehydration of D-mannonate
b4323	316407.85677066	5.6e-288	996.1	Escherichia	uxuB	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008866,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019585,GO:0019752,GO:0032787,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.57	ko:K00040	ko00040,ko01100,map00040,map01100	M00061	R02454	RC00085	ko00000,ko00001,ko00002,ko01000			iAPECO1_1312.APECO1_2108,iECOK1_1307.ECOK1_4822,iUMN146_1321.UM146_22300,iUTI89_1310.UTI89_C5019	Escherichia	1MVZ7@1224,1RNIZ@1236,3XP48@561,COG0246@1,COG0246@2	NA|NA|NA	G	Belongs to the mannitol dehydrogenase family
b4324	316407.85677067	8.5e-142	509.6	Escherichia	uxuR	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576		ko:K13637					ko00000,ko03000				Escherichia	1MY1K@1224,1RMUE@1236,3XMVC@561,COG2186@1,COG2186@2	NA|NA|NA	K	Uxu operon transcriptional regulator
b4325	316407.85677068	1.8e-161	575.1	Escherichia	yjiC												Escherichia	1NQYJ@1224,1SM8F@1236,2F0KM@1,33TP9@2,3XQXP@561	NA|NA|NA	S	Protein of unknown function (DUF2686)
b4326	316407.85677069	7.5e-70	269.6	Escherichia	iraD	GO:0000988,GO:0000989,GO:0003674,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033554,GO:0042176,GO:0042177,GO:0043856,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051248,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141		ko:K21637					ko00000				Escherichia	1NQRH@1224,1SKQV@1236,3XR2S@561,COG3518@1,COG3518@2	NA|NA|NA	S	Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway
b4327	316407.85677070	3.9e-170	604.0	Escherichia	yjiE	GO:0000976,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:1990837,GO:2000112,GO:2001141		ko:K21645					ko00000,ko03000				Escherichia	1R4QT@1224,1RR79@1236,3XQW2@561,COG0583@1,COG0583@2	NA|NA|NA	K	Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur- regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study
b4328	316407.85677071	5.6e-222	776.5	Escherichia	iadA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008270,GO:0008798,GO:0016787,GO:0019538,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564		ko:K01305					ko00000,ko01000,ko01002				Escherichia	1QUJ0@1224,1T26K@1236,3XP62@561,COG1820@1,COG1820@2	NA|NA|NA	E	Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation
b4329	155864.EDL933_5667	7.4e-77	293.1	Escherichia	yjiG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1R4W8@1224,1T006@1236,3XQ0K@561,COG0700@1,COG0700@2	NA|NA|NA	S	Nucleoside recognition
b4330	155864.EDL933_5668	2e-118	431.8	Escherichia	yjiH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1NP3U@1224,1RNFQ@1236,3XPX4@561,COG3366@1,COG3366@2	NA|NA|NA	S	Nucleoside recognition
b4331	316407.85677074	3.4e-100	370.9	Escherichia	kptA	GO:0003674,GO:0003824,GO:0016740,GO:0016772		ko:K07559					ko00000,ko01000,ko03016				Escherichia	1RD8B@1224,1S3U6@1236,3XQCV@561,COG1859@1,COG1859@2	NA|NA|NA	J	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
b4332	316407.85677075	2.5e-209	734.6	Escherichia	yjiJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1QWCC@1224,1T2TN@1236,3XQ4A@561,COG0477@1,COG0477@2	NA|NA|NA	EGP	Uncharacterised MFS-type transporter YbfB
b4333	316407.85677076	3.9e-156	557.4	Escherichia	yjiK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1NAG1@1224,1S2XD@1236,3XQE6@561,COG3204@1,COG3204@2	NA|NA|NA	S	Esterase-like activity of phytase
b4715	481805.EcolC_3730	4.2e-45	186.8	Gammaproteobacteria													Escherichia	1N7MK@1224,1SD2C@1236,2E4RX@1,32ZKF@2	NA|NA|NA	S	Protein of unknown function (DUF3343)
b4334	316407.85677077	5.1e-139	500.4	Escherichia	yjiL												Escherichia	1R6HU@1224,1RQ2H@1236,3XN6E@561,COG1924@1,COG1924@2	NA|NA|NA	I	4 iron, 4 sulfur cluster binding
b4335	316407.85677078	1.6e-221	775.0	Escherichia	yjiM	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1NNW9@1224,1RPEE@1236,3XNW9@561,COG1775@1,COG1775@2	NA|NA|NA	E	lyase activity
b4336	316407.85677079	1.8e-237	828.2	Escherichia	yjiN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944											Escherichia	1MX3G@1224,1RNR7@1236,3XMNE@561,COG2733@1,COG2733@2	NA|NA|NA	S	Protein of unknown function (DUF445)
b4337	316407.85677080	5.4e-223	780.0	Escherichia	mdtM	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006855,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015238,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015307,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0015893,GO:0016020,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042493,GO:0042592,GO:0044464,GO:0046618,GO:0046677,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600											Escherichia	1MUWH@1224,1RRF6@1236,3XQTZ@561,COG0477@1,COG2814@2	NA|NA|NA	P	Confers resistance to acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP
b4584	199310.c5420	1.2e-163	582.4	Escherichia	rpnD												Escherichia	1MUSP@1224,1RNUW@1236,3XNRC@561,COG5464@1,COG5464@2	NA|NA|NA	S	Putative transposase, YhgA-like
b4340	316407.85677082	6.9e-275	952.6	Escherichia	yjiR	GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576											Escherichia	1MV6F@1224,1RMQ0@1236,3XQJT@561,COG1167@1,COG1167@2	NA|NA|NA	K	transaminase activity
b4341	316407.85677083	7e-22	109.0	Escherichia	yjiS												Escherichia	1NKWS@1224,1SHB3@1236,3XRBS@561,COG5457@1,COG5457@2	NA|NA|NA	S	Domain of unknown function (DUF1127)
b4342	316407.85677084	7.4e-299	1032.3	Gammaproteobacteria													Escherichia	1QYXK@1224,1T3WW@1236,COG1196@1,COG1196@2	NA|NA|NA	D	nuclear chromosome segregation
b4486	630626.EBL_c34740	0.0	1395.6	Gammaproteobacteria													Escherichia	1MVGH@1224,1RQXN@1236,COG1201@1,COG1201@2,COG1205@1,COG1205@2	NA|NA|NA	L	dEAD DEAH box helicase
b4345	316407.85677085	5.2e-203	713.4	Gammaproteobacteria													Escherichia	1R1FP@1224,1RZIR@1236,COG4268@1,COG4268@2	NA|NA|NA	V	DNA restriction-modification system
b4346	316407.85677086	4.8e-273	946.4	Escherichia	mcrB	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003924,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015666,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0017111,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901361,GO:1901363,GO:1901575		ko:K07452					ko00000,ko01000,ko02048				Escherichia	1MYQM@1224,1RSU7@1236,3XR9B@561,COG1401@1,COG1401@2	NA|NA|NA	L	also binds to GTP. Isoform 33 kDa is less active than isoform 51 kDa and may play a role in regulating the activity of isoform 51 kDa by competing with it in DNA and protein binding abilities
b4347	316407.85677087	1.6e-55	221.9	Escherichia	symE	GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009432,GO:0009605,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0019222,GO:0019439,GO:0031668,GO:0033554,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575		ko:K19048					ko00000,ko02048				Escherichia	1RIS1@1224,1S7E6@1236,2DM63@1,31VID@2,3XQ5J@561	NA|NA|NA	J	Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease Lon
b4348	316407.85677088	1.8e-259	901.4	Gammaproteobacteria													Escherichia	1MXVH@1224,1S29W@1236,COG0732@1,COG0732@2	NA|NA|NA	V	COG0732 Restriction endonuclease S subunits
b4349	316407.85677089	0.0	1083.6	Escherichia	hsdM	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.72	ko:K03427					ko00000,ko01000,ko02048				Escherichia	1MW3A@1224,1RRVF@1236,3XRHX@561,COG0286@1,COG0286@2	NA|NA|NA	J	The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'
b4350	316407.85677090	0.0	2229.1	Escherichia	hsdR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.1.21.3	ko:K01153					ko00000,ko01000,ko02048				Escherichia	1QTS7@1224,1RN63@1236,3XQUG@561,COG4096@1,COG4096@2	NA|NA|NA	L	The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'. Subunit R is required for both nuclease and ATPase activities, but not for modification
b4351	316407.85677091	2.3e-170	604.7	Escherichia	mrr	GO:0001101,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009295,GO:0009415,GO:0009628,GO:0009987,GO:0010035,GO:0015666,GO:0016787,GO:0016788,GO:0032067,GO:0034641,GO:0042221,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051599,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901700		ko:K07448					ko00000,ko02048				Escherichia	1Q2VY@1224,1RYEE@1236,3XQ4J@561,COG1715@1,COG1715@2	NA|NA|NA	J	Involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA
b4352	316407.85677092	6.1e-182	643.3	Escherichia	yjiA	GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0033554,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716											Escherichia	1MVZV@1224,1RQDY@1236,3XNSG@561,COG0523@1,COG0523@2	NA|NA|NA	S	GTPase activity
b4353	1440052.EAKF1_ch1494	9.9e-34	148.7	Escherichia	yjiX	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716											Escherichia	1N6TY@1224,1S8VA@1236,3XR4J@561,COG2879@1,COG2879@2	NA|NA|NA	S	Selenoprotein, putative
b4354	316407.85677094	0.0	1403.3	Escherichia	yjiY	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944											Escherichia	1MWF9@1224,1RMG4@1236,3XMEQ@561,COG1966@1,COG1966@2	NA|NA|NA	T	Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS BtsR and YpdA YpdB, and their respective target proteins, YjiY and YhjX
b4355	316407.85677095	2.3e-213	748.4	Escherichia	tsr	GO:0001101,GO:0001932,GO:0003674,GO:0004888,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0006935,GO:0007154,GO:0007165,GO:0007172,GO:0008104,GO:0008150,GO:0009593,GO:0009605,GO:0009719,GO:0009966,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019220,GO:0019222,GO:0019899,GO:0019900,GO:0019901,GO:0022607,GO:0023051,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031399,GO:0032101,GO:0032110,GO:0032268,GO:0032879,GO:0032991,GO:0033036,GO:0034613,GO:0034622,GO:0038023,GO:0040011,GO:0040012,GO:0042221,GO:0042325,GO:0042330,GO:0042802,GO:0042803,GO:0043113,GO:0043200,GO:0043424,GO:0043549,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0046983,GO:0048583,GO:0048870,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051174,GO:0051179,GO:0051246,GO:0051259,GO:0051260,GO:0051270,GO:0051338,GO:0051606,GO:0051641,GO:0051668,GO:0051674,GO:0051716,GO:0060089,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0070727,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071840,GO:0071944,GO:0072657,GO:0080090,GO:0098561,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902021,GO:2000145		ko:K05874	ko02020,ko02030,map02020,map02030				ko00000,ko00001,ko02035				Escherichia	1MU9B@1224,1RMH0@1236,3XNKT@561,COG0840@1,COG0840@2	NA|NA|NA	NT	Methyl-accepting chemotaxis protein
b4356	316407.85677096	1.1e-256	892.1	Escherichia	lgoT	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0015711,GO:0015718,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0034220,GO:0042873,GO:0044425,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039										iEC55989_1330.EC55989_4444,iEcE24377_1341.EcE24377A_4501	Escherichia	1MVPS@1224,1RPRB@1236,3XP6M@561,COG2271@1,COG2271@2	NA|NA|NA	P	Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L-galactonate as the sole carbon source
b4357	316407.85677097	4.6e-171	607.1	Escherichia	yjjM	GO:0005975,GO:0006082,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016052,GO:0016054,GO:0019219,GO:0019222,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0031323,GO:0031326,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0072329,GO:0080090,GO:1901575,GO:1903506,GO:2000112,GO:2001141											Escherichia	1R56F@1224,1RNQY@1236,3XQ5A@561,COG1802@1,COG1802@2	NA|NA|NA	K	Transcriptional regulator
b4358	316407.85677098	1.9e-194	684.9	Escherichia	JD73_14225	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019520,GO:0019583,GO:0019584,GO:0019752,GO:0032787,GO:0034193,GO:0034195,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575										iSSON_1240.SSON_4504	Escherichia	1MWX0@1224,1RR1W@1236,3XQDT@561,COG1063@1,COG1063@2	NA|NA|NA	C	Catalyzes the oxidation of L-galactonate to D- tagaturonate. Required for growth on L-galactonate as the sole carbon source. In vitro, can also use L-gulonate
b4359	316407.85677099	0.0	1560.0	Escherichia	mdoB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006490,GO:0006629,GO:0008150,GO:0008152,GO:0008960,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0042597,GO:0044237,GO:0044238,GO:0044255,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576	2.7.8.20	ko:K01002	ko01100,map01100				ko00000,ko01000				Escherichia	1MVCM@1224,1RNJ3@1236,3XP4B@561,COG1368@1,COG1368@2	NA|NA|NA	M	Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones
b4360	316407.85677100	3.7e-82	310.8	Escherichia	yjjA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464											Escherichia	1N1I7@1224,1S9J1@1236,2B7M6@1,320SA@2,3XPG7@561	NA|NA|NA	S	Protein of unknown function (DUF2501)
b4361	155864.EDL933_5704	2.4e-133	481.5	Escherichia	dnaC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0022616,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576		ko:K02315					ko00000,ko03032				Escherichia	1MZNW@1224,1RQFW@1236,3XMDA@561,COG1484@1,COG1484@2	NA|NA|NA	L	This protein is required for chromosomal replication. It forms, in concert with DnaB protein and other prepriming proteins DnaT, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'
b4362	198214.SF4393	5.8e-97	360.1	Gammaproteobacteria													Escherichia	1PJ9A@1224,1RYK1@1236,28IQ3@1,2Z8PW@2	NA|NA|NA	L	it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'
b4363	155864.EDL933_5706	1.6e-79	302.0	Escherichia	yjjB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0010033,GO:0010243,GO:0015711,GO:0015740,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901652,GO:1901698,GO:1901700											Escherichia	1RAWK@1224,1S2KX@1236,3XN8X@561,COG3610@1,COG3610@2	NA|NA|NA	S	response to peptide
b4364	198214.SF4395	7.2e-141	506.5	Gammaproteobacteria													Escherichia	1NH2X@1224,1RN1Q@1236,COG2966@1,COG2966@2	NA|NA|NA	S	Membrane
b4365	155864.EDL933_5708	2.8e-131	474.6	Escherichia	yjjQ	GO:0008150,GO:0010033,GO:0042221,GO:0050896,GO:0051595,GO:1901654,GO:1901700											Escherichia	1MWAP@1224,1RQ0X@1236,3XMZU@561,COG2197@1,COG2197@2	NA|NA|NA	K	response to methylglyoxal
b4366	155864.EDL933_5709	1.2e-120	439.1	Escherichia	bglJ	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009314,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141											Escherichia	1RBIN@1224,1S2HI@1236,3XMED@561,COG2197@1,COG2197@2	NA|NA|NA	K	Transcriptional activator protein BglJ
b4367	316407.85677107	1.7e-153	548.5	Escherichia	fhuF	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0009987,GO:0016020,GO:0019725,GO:0030003,GO:0033212,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051540,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071944,GO:0098771		ko:K13255					ko00000			iE2348C_1286.E2348C_4666,iECH74115_1262.ECH74115_5880,iECNA114_1301.ECNA114_4609,iECSP_1301.ECSP_5450,iECs_1301.ECs5327,iG2583_1286.G2583_5169,iSBO_1134.SBO_4427,iZ_1308.Z5968	Escherichia	1MWSR@1224,1RSNM@1236,3XNBX@561,COG4114@1,COG4114@2	NA|NA|NA	S	ferric iron reductase
b4567	316407.85677108	6.1e-35	152.9	Escherichia	yjjZ												Escherichia	1N033@1224,1SC0F@1236,2CF73@1,32RSY@2,3XQ33@561	NA|NA|NA	S	Protein of unknown function (DUF1435)
b4371	316407.85677109	1.9e-197	694.9	Escherichia	rsmC	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052914,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.172	ko:K00564			R07234	RC00003	ko00000,ko01000,ko03009				Escherichia	1MXE9@1224,1RQCH@1236,3XP64@561,COG2813@1,COG2813@2	NA|NA|NA	J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle
b4372	316407.85677110	9.9e-73	279.3	Escherichia	holD	GO:0008150,GO:0009314,GO:0009628,GO:0050896	2.7.7.7	ko:K02344	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400				Escherichia	1RH2F@1224,1S634@1236,3XPMT@561,COG3050@1,COG3050@2	NA|NA|NA	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
b4373	155864.EDL933_5714	1.1e-77	295.8	Escherichia	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789					ko00000,ko01000,ko03009				Escherichia	1RIE6@1224,1S9G0@1236,3XN7X@561,COG0454@1,COG0456@2	NA|NA|NA	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18
b4374	155864.EDL933_5715	2.1e-128	464.9	Escherichia	yjjG	GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006206,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008655,GO:0009058,GO:0009112,GO:0009410,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019856,GO:0019859,GO:0030145,GO:0034641,GO:0034654,GO:0042221,GO:0042578,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.5	ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000			iECNA114_1301.ECNA114_4614	Escherichia	1MVF8@1224,1RMK3@1236,3XNKE@561,COG1011@1,COG1011@2	NA|NA|NA	S	Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo, since the general nucleotidase activity of YjjG allows it to protect cells against non-canonical pyrimidine derivatives such as 5-fluoro-2'-deoxyuridine, 5-fluorouridine, 5- fluoroorotate, 5-fluorouracil, and 5-aza-2'-deoxycytidine, and prevents the incorporation of potentially mutagenic nucleotides into DNA. Its dUMP phosphatase activity that catalyzes the hydrolysis of dUMP to deoxyuridine is necessary for thymine utilization via the thymine salvage pathway. Is strictly specific to substrates with 5'-phosphates and shows no activity against nucleoside 2'- or 3'-monophosphates
b4375	155864.EDL933_5716	3.7e-309	1066.6	Escherichia	prfC	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0022411,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032984,GO:0034641,GO:0034645,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576		ko:K02837					ko00000,ko03012				Escherichia	1MU7X@1224,1RMFT@1236,3XNAI@561,COG4108@1,COG4108@2	NA|NA|NA	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
b4376	199310.c5457	1.1e-96	359.4	Escherichia	osmY	GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077		ko:K04065					ko00000				Escherichia	1PCIJ@1224,1RRGP@1236,3XN0N@561,COG2823@1,COG2823@2	NA|NA|NA	S	hyperosmotic response
b4568	1218086.BBNB01000016_gene1658	3.5e-18	96.7	Citrobacter													Escherichia	1NGAH@1224,1SGD7@1236,3WYW6@544,COG5487@1,COG5487@2	NA|NA|NA	S	Protein of unknown function (DUF1328)
b4377	316407.85677116	1.5e-208	731.9	Escherichia	yjjU	GO:0003674,GO:0003824,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016787,GO:0033554,GO:0050896,GO:0051716											Escherichia	1PV7M@1224,1RRPR@1236,3XNUQ@561,COG4667@1,COG4667@2	NA|NA|NA	S	lipid catabolic process
b4378	316407.85677117	2.6e-146	524.6	Escherichia	yjjV			ko:K03424					ko00000,ko01000				Escherichia	1MW5C@1224,1RP5T@1236,3XP1T@561,COG0084@1,COG0084@2	NA|NA|NA	L	endodeoxyribonuclease activity, producing 5'-phosphomonoesters
b4379	316407.85677118	2.5e-150	538.1	Escherichia	yjjW												Escherichia	1QIC8@1224,1RRCB@1236,3XPBI@561,COG1180@1,COG1180@2	NA|NA|NA	O	4 iron, 4 sulfur cluster binding
b4380	316407.85677119	2.4e-305	1053.9	Escherichia	yjjI	GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0044237,GO:0045333,GO:0055114											Escherichia	1N1EN@1224,1RP1S@1236,3XMK1@561,COG1328@1,COG1328@2	NA|NA|NA	F	anaerobic respiration
b4381	199310.c5465	6.8e-139	500.0	Escherichia	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0015949,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030		R01066	RC00436,RC00437	ko00000,ko00001,ko01000			iEcSMS35_1347.EcSMS35_4930	Escherichia	1N8AG@1224,1RPTS@1236,3XMSF@561,COG0274@1,COG0274@2	NA|NA|NA	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
b4382	316407.85677121	2e-244	851.3	Escherichia	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009032,GO:0009116,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0033554,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072527,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219		R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000			iB21_1397.B21_04224,iEC042_1314.EC042_4879,iECBD_1354.ECBD_3638,iECB_1328.ECB_04258,iECD_1391.ECD_04258,iECH74115_1262.ECH74115_5897,iECIAI1_1343.ECIAI1_4605,iECIAI39_1322.ECIAI39_4914,iECSE_1348.ECSE_4657,iECSP_1301.ECSP_5465,iECUMN_1333.ECUMN_5006,iECW_1372.ECW_m4744,iEKO11_1354.EKO11_3932,iETEC_1333.ETEC_4738,iEcE24377_1341.EcE24377A_4981,iEcSMS35_1347.EcSMS35_4931,iEcolC_1368.EcolC_3674,iG2583_1286.G2583_5242,iSSON_1240.SSON_4533,iSbBS512_1146.SbBS512_E4929,iUMNK88_1353.UMNK88_5301,iWFL_1372.ECW_m4744,iZ_1308.Z5984,ic_1306.c5466	Escherichia	1MV3H@1224,1RPTG@1236,3XNQE@561,COG0213@1,COG0213@2	NA|NA|NA	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
b4383	155864.EDL933_5727	8.4e-245	852.4	Escherichia	deoB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230		R01057,R02749	RC00408	ko00000,ko00001,ko01000			iLF82_1304.LF82_0465,iNRG857_1313.NRG857_22165	Escherichia	1MVN8@1224,1RQ6W@1236,3XMQS@561,COG1015@1,COG1015@2	NA|NA|NA	F	Phosphotransfer between the C1 and C5 carbon atoms of pentose
b4384	155864.EDL933_5728	2.5e-132	478.0	Escherichia	deoD	GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009164,GO:0009987,GO:0015949,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0019686,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.1	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110		R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000			iAPECO1_1312.APECO1_1997,iB21_1397.B21_04226,iE2348C_1286.E2348C_4682,iEC042_1314.EC042_4881,iECABU_c1320.ECABU_c50190,iECBD_1354.ECBD_3636,iECB_1328.ECB_04260,iECD_1391.ECD_04260,iECED1_1282.ECED1_5255,iECIAI39_1322.ECIAI39_4916,iECNA114_1301.ECNA114_4626,iECO26_1355.ECO26_5590,iECOK1_1307.ECOK1_4950,iECP_1309.ECP_4768,iEcolC_1368.EcolC_3672,iLF82_1304.LF82_0467,iNRG857_1313.NRG857_22170,iSFV_1184.SFV_4418,iSF_1195.SF4416,iSFxv_1172.SFxv_4809,iS_1188.S4687,iUMN146_1321.UM146_22680,iUMNK88_1353.UMNK88_5303,iUTI89_1310.UTI89_C5155,ic_1306.c5468	Escherichia	1MUW6@1224,1RMMA@1236,3XP9J@561,COG0813@1,COG0813@2	NA|NA|NA	F	Purine nucleoside phosphorylase
b4385	316407.85677124	3.5e-260	903.7	Escherichia	yjjJ	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363											Escherichia	1QJ5P@1224,1RP64@1236,3XQTA@561,COG3550@1,COG3550@2	NA|NA|NA	S	Toxic when overexpressed in E.coli, leading to long filamentous cells. The toxic effect is neutralized by non-cognate antitoxin HipB. Does not seem to inhibit DNA, RNA or protein synthesis, and unlike paralogous toxin HipA its toxic activity is not counteracted by overexpression of GltX. Binds DNA. Might be a protein kinase (By similarity)
b4386	316407.85677125	3.5e-196	690.6	Escherichia	lplA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0017118,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:0140096,GO:1901564	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100		R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000			iBWG_1329.BWG_4078,iE2348C_1286.E2348C_4684,iECDH10B_1368.ECDH10B_4544,iECDH1ME8569_1439.ECDH1ME8569_4242,iEcDH1_1363.EcDH1_3612,iJO1366.b4386,iSDY_1059.SDY_4647,iY75_1357.Y75_RS22890	Escherichia	1N1T8@1224,1RMGI@1236,3XMVY@561,COG0095@1,COG0095@2	NA|NA|NA	J	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes
b4387	155864.EDL933_5730	1.4e-110	405.6	Escherichia	lplA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0017118,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:0140096,GO:1901564	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100		R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000			iBWG_1329.BWG_4078,iE2348C_1286.E2348C_4684,iECDH10B_1368.ECDH10B_4544,iECDH1ME8569_1439.ECDH1ME8569_4242,iEcDH1_1363.EcDH1_3612,iJO1366.b4386,iSDY_1059.SDY_4647,iY75_1357.Y75_RS22890	Escherichia	1N1T8@1224,1RMGI@1236,3XMVY@561,COG0095@1,COG0095@2,COG3726@1,COG3726@2	NA|NA|NA	J	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes
b4388	155864.EDL933_5731	4e-181	640.6	Escherichia	serB	GO:0000287,GO:0003674,GO:0003824,GO:0004647,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019752,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046872,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009			iE2348C_1286.E2348C_4686,iEC042_1314.EC042_4885,iECO26_1355.ECO26_5594,iECSF_1327.ECSF_4321,iECUMN_1333.ECUMN_5012,iETEC_1333.ETEC_4743,iUMNK88_1353.UMNK88_5307	Escherichia	1MWA3@1224,1RNJE@1236,3XP59@561,COG0560@1,COG0560@2	NA|NA|NA	E	Catalyzes the dephosphorylation of phosphoserine (P- Ser)
b4389	316407.85677128	2.2e-257	894.4	Escherichia	radA	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363		ko:K04485					ko00000,ko03400				Escherichia	1MUJQ@1224,1RN2E@1236,3XNG4@561,COG1066@1,COG1066@2	NA|NA|NA	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
b4390	316407.85677129	1.1e-228	798.9	Escherichia	nadR	GO:0000166,GO:0000287,GO:0000309,GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009268,GO:0009435,GO:0009628,GO:0009987,GO:0010035,GO:0010038,GO:0010446,GO:0016043,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0022607,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043565,GO:0043933,GO:0044085,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0046872,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055086,GO:0065003,GO:0070566,GO:0070887,GO:0071241,GO:0071248,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	2.7.1.22,2.7.7.1	ko:K06211	ko00760,ko01100,map00760,map01100		R00137,R02324,R03005	RC00002,RC00017	ko00000,ko00001,ko01000,ko03000			iECSE_1348.ECSE_4665	Escherichia	1MUSI@1224,1RPHP@1236,3XNA4@561,COG1056@1,COG1056@2,COG3172@1,COG3172@2	NA|NA|NA	H	This enzyme has three activities DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD( ). The NMN adenylyltransferase domain also functions as the NAD and ATP sensor
b4391	155864.EDL933_5735	0.0	1105.1	Escherichia	yjjK	GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113											Escherichia	1MU37@1224,1RPWS@1236,3XN7U@561,COG0488@1,COG0488@2	NA|NA|NA	S	A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation
b4392	155864.EDL933_5736	0.0	1293.1	Escherichia	slt	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009274,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575		ko:K08309					ko00000,ko01000,ko01011		GH23	iETEC_1333.ETEC_4747	Escherichia	1MV3F@1224,1RMS8@1236,3XMM5@561,COG0741@1,COG0741@2	NA|NA|NA	M	Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and or cell division
b4393	155864.EDL933_5737	2e-52	211.5	Escherichia	trpR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141		ko:K03720					ko00000,ko03000				Escherichia	1MYB2@1224,1S6RH@1236,3XPUK@561,COG2973@1,COG2973@2	NA|NA|NA	K	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
b4394	316407.85677133	5e-90	337.0	Escherichia	yjjX	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564										iECO111_1330.ECO111_5255	Escherichia	1R60T@1224,1RNVT@1236,3XM8I@561,COG1986@1,COG1986@2	NA|NA|NA	F	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
b4395	155864.EDL933_5739	2.5e-118	431.4	Escherichia	gpmB		5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000			iZ_1308.Z5997	Escherichia	1NPC4@1224,1RSEU@1236,3XN8A@561,COG0406@1,COG0406@2	NA|NA|NA	F	Belongs to the phosphoglycerate mutase family. GpmB subfamily
b4396	155864.EDL933_5740	2e-168	598.2	Escherichia	rob	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019243,GO:0019249,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0043565,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046394,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:0097159,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901617		ko:K05804		M00647,M00767			ko00000,ko00002,ko03000,ko03036				Escherichia	1MWTF@1224,1RQMF@1236,3XMHC@561,COG2207@1,COG2207@2,COG3708@1,COG3708@2	NA|NA|NA	K	Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein structure, required for oriC function in the initiation of replication
b4397	155864.EDL933_5741	4.6e-82	310.5	Escherichia	creA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K05805					ko00000				Escherichia	1RDMP@1224,1S29X@1236,3XNHF@561,COG3045@1,COG3045@2	NA|NA|NA	S	CreA protein
b4398	316407.85677137	6.2e-128	463.4	Escherichia	creB	GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141		ko:K07663	ko02020,map02020	M00449			ko00000,ko00001,ko00002,ko02022				Escherichia	1MVCB@1224,1RM87@1236,3XRJ6@561,COG0745@1,COG0745@2	NA|NA|NA	K	Member of the two-component regulatory system CreC CreB involved in catabolic regulation
b4399	316407.85677138	7.2e-264	916.0	Escherichia	creC	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031667,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07641	ko02020,map02020	M00449			ko00000,ko00001,ko00002,ko01000,ko01001,ko02022				Escherichia	1N17V@1224,1RPVU@1236,3XM7C@561,COG0642@1,COG2205@2	NA|NA|NA	T	PhoQ Sensor
b4400	316407.85677139	2.2e-254	884.4	Escherichia	creD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944		ko:K06143					ko00000				Escherichia	1MVVR@1224,1RQRZ@1236,3XMF1@561,COG4452@1,COG4452@2	NA|NA|NA	V	Inner membrane protein CreD
b4401	1440052.EAKF1_ch1423	1.8e-133	481.9	Escherichia	arcA	GO:0000156,GO:0000160,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0035556,GO:0042802,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141		ko:K07773	ko02020,ko02026,map02020,map02026	M00456			ko00000,ko00001,ko00002,ko02022				Escherichia	1MWJG@1224,1RPU3@1236,3XN3D@561,COG0745@1,COG0745@2	NA|NA|NA	K	It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter
b4402	316407.85677141	7.1e-15	85.5	Proteobacteria													Escherichia	1NEAG@1224,2CBE6@1,334KS@2	NA|NA|NA		
b4403	316407.85677142	3.9e-122	444.1	Escherichia	lasT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464		ko:K02533					ko00000,ko01000,ko03016				Escherichia	1MUKP@1224,1RMZX@1236,3XMAY@561,COG0565@1,COG0565@2	NA|NA|NA	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
# 4208 queries scanned
# Total time (seconds): 120.570057154
# Rate: 34.90 q/s
