
V.1.3
Added several pathways associated with carotenoid biosynthesis, including
end-products: astaxanthin, nostoxanthin, zeaxanthin diglucoside, & 
myxoxanthophylls. Plus, staphyloaxanthin biosynthesis and the two pathways for
terpenoid building blocks, the mevalonate pathway and the MEP/DOXP pathway.
The pathways were provided by Dr. Tania Kurbessoian
V.1.2.1
Added all-trans-8'-apo-beta-carotenal 15,15'-oxygenase which will cleave
apo-carotenals to generate retinal. Upstream pathway unknown
V.1.2
Added several new pathways including PET degradation, carbon storage,
related to starch/gylcogen & polyhydroxybutyrate, and posphate storage,
related to the reversible polyphosphate reaction. Part of summer research
with Sheyla Aviles.
V.1.1
Correcting typos identified by Chris Neely. Adding more complete
pathways components for amino acid biosynthesis identified by
Dr. Eric Webb
phenylalanine added K01713 pheC; cyclohexadienyl dehydratase OR K05359 ADT; 
arogenate/prephenate dehydratase OR K04518 pheA2; prephenate dehydratase
tyrosine added K00220 tyrC; cyclohexadieny/prephenate dehydrogenase OR 
K24018; cyclohexadieny/prephenate dehydrogenase OR K15226 tyrAa; arogenate dehydrogenase
V.1.0.10
Add the biosynthesis of the 20 amino acids - represented as the last
step in the pathway
KEGG-decoder.py V.1.0.8.2
V.1.0.8
Several recent updates have improved all three outputs for visualization
expanded further in the ReadMe note. Additionally, a correction to 
determining the completeness of ubiquinol-cytochrome c reductase. Previously,
only checked for the presence of K00411 and K00410. K00410 is a fusion of
K00412 and K00413 only present in a subset of Proteobacteria. Identified
by Grayson Chadwick
V.1.0.5
Added tanglegram correction for minimizing euclidean distance
V.1.0.4
Removed check for small datasets in interactive viz, added autosizing of tanglegram plots,
switch similarity metric in tanglegram to braycurtis
V.1.0.3
Quality of life updates for KEGG-decoder, tangelgram option, and interactive plots
V.1.0.2
Adds Na+-transporting NADH:ubiquinone oxidoreductase and several metal transporters
KEGG-decoder.py V.0.8
V0.8
Add elements regarding arsenic reduction
V.0.7
Clarifies elements of methane oxidation and adds additional methanol/alcohol dehydrogenase
to KEGG function search. Adds the serine pathway for formaldehyde assimilation
V.0.6.1
V.0.6.1 Corrects an issue with the Wood-Ljungdhal pathway that used the wrong
carbon-monoxide deydrogenase subunit
V.0.6 Adds Bacterial Secretion Systems as descrived by KEGG covering Type I, II, III, IV, Vabc, VI, Sec-SRP and Twin Arginine Targeting systems
V.0.5 Adds functions for sulfolipid biosynthesis (key gene sqdB) and C-P lyase
V.0.3. Adds retinal biosynthesis, sulfite dehydrogenase (quinone), hydrazine dehydrogenase, hydrazine synthase, DMSP/DMS/DMSO cycling, cobalamin biosynthesis, competence-related DNA transport, anaplerotic reactions
Nitrogen metabolism
	Dissimilatory nitrate reduction requires narGH K00370 + K00371 AND/OR napAB K02567 + K02568
	Nitrite oxidation requires nxrAB K00370 + K00371
	DNRA requires nirBD (K00362 + K00363) and/or nrfAH K03385 + K15876
	Denitrification step of nitrite reduction NO2 > NO requires nirK K00368 OR nirS K15864
	Denitrification step of nitric oxide reduction NO > N2O requires norBC K04561 + K02305
	Denitrification step of nitrous-oxide reduction N2O > N2 requires nosZ K00376
	Nitrogen fixation requires the nifKDH (K02586 + K02591 + K02588)
	Nitrification by bacteria hydroxylamine to nitrite NH2OH > NO2 requires hao K10535
	Nitrification ammonium to hydroxylamine NH4 > N2OH for detection, amoA (K10944) is essential and amoBC (K10945 + K10946) supports functional potential
	Anammox requires hydroxylamine oxidoreductase (K10535) and nirK or nirS (K00368 or K15864)
		hydrazine dehydrogenase K20935
		hydrazine synthase (K20932 + K20933 + K20934)


glycolysis as a pathway measured as a fraction of the following KOs: 
		phosphoglucomutase K01835
		glucose-6-phosphate isomerase K01810
		6-phosphofructokinase K00850 OR pyrophosphate--fructose-6-phosphate 1-phosphotransferase K00895
		fructose-bisphosphate aldolase K01623
		glyceraldehyde 3-phosphate dehydrogenase K00134 OR glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) K00150
		phosphoglycerate kinase K00927
		2,3-bisphosphoglycerate-dependent phosphoglycerate mutase K01834 OR 2,3-bisphosphoglycerate-independent phosphoglycerate mutase K15633
		enolase K01689
		pyruvate kinase K00873 OR pyruvate, orthophosphate dikinase K01006

gluconeogenesis requires fructose-1,6-bisphosphatase K03841 to reverse reaction, also requires all other parts of glycolysis EXCEPT for K00850/K00895

TCA cycle as measured as a fraction of the following KOs:
		aconitate hydratase - 2 subunits K01681 & K01682
		isocitrate dehydrogenase K00031 OR isocitrate dehydrogenase (NAD+) K00030 OR isocitrate--homoisocitrate dehydrogenase K17753
		2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase korAB essential K00174 + K00175 ALSO check for korCD K00177 & K00176
		succinyl-CoA synthetase K01899 + K01900 OR succinyl-CoA synthetase K01902 + K01903 OR succinyl-CoA:acetate CoA-transferase K18118
		fumarate reductase (K00244 + K00245 + K00246 + K00247) OR succinate dehydrogenase / fumarate reductase (K00239 + K00240 + K00241 + K00242) OR succinate dehydrogenase (ubiquinone) (K00234 + K00235 + K00236 + K00237)
		fumarate hydratase (K01677 + K01678 + K01679)
		malate dehydrogenase (quinone) K00116 OR K00025 OR K00026 OR K00024
		citrate synthase K01647

CBB cycle measured as a fraction of the following KOs:
		FIRST check and report presence of RuBisCo - ribulose-bisphosphate carboxylase (Type 1) two subunits K01601 + K01602
		Then check for 3 essential steps in canonical cycle:
		phosphoglycerate kinase K00927
		glyceraldehyde 3-phosphate dehydrogenase K00134 OR glyceraldehyde-3-phosphate dehydrogenase (NADP+) K05298 OR glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) K00150
		phosphoribulokinase K00855
		Then check for ribulose regeneration (several alternative pathways):
		Option 1 - ribulose-phosphate 3-epimerase K01783 AND xylulose-5-phosphate/fructose-6-phosphate phosphoketolase K01621
		Option 2 - transketolase K00615	AND ribulose-phosphate 3-epimerase K01783
		Option 3 - transketolase K00615	AND ribose 5-phosphate isomerase A K01807
		Option 4 - fructose-bisphosphate aldolase, class I K01623 OR fructose-bisphosphate aldolase, class II K01624 OR fructose-bisphosphate aldolase, class I K11645
					transketolase K00615
					Some combination of these genes:
					fructose-1,6-bisphosphatase II / sedoheptulose-1,7-bisphosphatase K11532
					fructose-1,6-bisphosphatase I K03841 
					fructose-1,6-bisphosphatase II K02446

Reverse TCA cycle display completeness of TCA cycle, check for essential gene components:
		Requires
		Option 1 - ATP-citrate lyase K15230 + K15231
		Option 2 - citryl-CoA synthetase K15232 + K152333 AND citryl-CoA lyase K15234

Wood-Ljungdahl pathway requires some essential genes and pathway fraction:
		Essential:
		Option 1 (when fused) - acetyl-CoA decarbonylase/synthase complex subunit alpha K00192 AND carbon-monoxide dehydrogenase K00198 + K00196 OR carbon-monoxide dehydrogenase K03520 + K03518 + K03519
		Option 2 - CO-methylating acetyl-CoA synthase K14138 AND carbon-monoxide dehydrogenase K00198 + K00196 OR carbon-monoxide dehydrogenase K03520 + K03518 + K03519
		Methyl branch:
		formate dehydrogenase K05299 + K15022
		formate--tetrahydrofolate ligase K01938
		methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase K01491
		methylenetetrahydrofolate reductase (NADPH) K00297

3-hydroxypropionate pathway measured as a fraction of the following KOs:
	Two separate pathways cycling from acetyl-CoA
	Pathway 1:
		pyruvate ferredoxin oxidoreductase K00169 + K00170 + K00171 + K00172 + K03737
		pyruvate, orthophosphate dikinase K01006 OR pyruvate, water dikinase K01007
		phosphoenolpyruvate carboxylase K01595
		malate dehydrogenase K00024
		succinyl-CoA:(S)-malate CoA-transferase K14471 + K14472
		malyl-CoA/(S)-citramalyl-CoA lyase K08691
	Pathway 2:
		acetyl-CoA carboxylase, biotin carboxylase K02160 + K01961 + K01962 + K01963 + K01964 + K15037 + K15036 + K18603 + K18604 + K18605
		malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+) K14468 + K15017
		3-hydroxypropionate dehydrogenase (NADP+) K15039
		acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase K14469 + K15018
		3-hydroxypropionyl-coenzyme A dehydratase K15019
		acryloyl-coenzyme A reductase K15020
		malyl-CoA/(S)-citramalyl-CoA lyase K08691
		2-methylfumaryl-CoA hydratase K14449
		2-methylfumaryl-CoA isomerase K14470
		3-methylfumaryl-CoA hydratase K09709
		malyl-CoA/(S)-citramalyl-CoA lyase K08691

4-hydroxybutyrate/3-hydroxypropionate cycle measures as a fraction of the following KOs:
		Reference from Thaumarchaea -- incomplete in KOs
		acetyl-CoA carboxylase, biotin carboxylase K02160 + K01961 + K01962 + K01963 + K01964 + K15037 + K15036 + K18603 + K18604 + K18605
		malonic semialdehyde reductase K18602
		3-hydroxypropionyl-CoA synthetase (ADP-forming) K18594
		acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase K14469 + K15019
		propionyl-CoA carboxylase K15052 + K01964 + K15037 + K15036 + K18603 + K18604 + K18605
		methylmalonyl-CoA/ethylmalonyl-CoA epimerase K05606
		methylmalonyl-CoA mutase K01847 + K01848 + K01849
		4-hydroxybutyryl-CoA synthetase (ADP-forming) K18593
		4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase K14534
		enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase K15016
		acetyl-CoA C-acetyltransferase K00626

Carbon degradation - Each enzyme taken as a single entity:
		beta-glucosidase K05350
		beta-glucosidase K05349
		cellulase K01225
		cellulase K19668
		chitinase K01183
		bifunctional chitinase/lysozyme K13381
		basic endochitinase B K20547
		diacetylchitobiose deacetylase K03478 OR K18454
		beta-N-acetylhexosaminidase K01207
		pectinesterase K01051
		exo-poly-alpha-galacturonosidase K01213
		oligogalacturonide lyase K01730
		exopolygalacturonase K01184
		D-galacturonate isomerase K01812
		D-galacturonate epimerase K08679
		alpha-amylase K01176
		glucoamylase K01178  
		pullulanase K01200  

Chemotaxis (as determined by Tara) KO fraction above a certain threshold:
	K13924	 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:3.1.1.61 2.1.1.80]
	K00575	 cheR; chemotaxis protein methyltransferase CheR [EC:2.1.1.80]
	K03413	 cheY; two-component system, chemotaxis family, response regulator CheY
	K03412	 cheB; two-component system, chemotaxis family, response regulator CheB [EC:3.1.1.61]
	K03406	 mcp; methyl-accepting chemotaxis protein
	K03407	 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
	K03415	 cheV; two-component system, chemotaxis family, response regulator CheV
	K03408	 cheW; purine-binding chemotaxis protein CheW

Flagellum biosynthesis (as determined by Tara) KO fraction above a certain threshold:
	K02409	 flagellar M-ring protein FliF
	K02401	 flagellar biosynthetic protein FlhB
	K02394	 flagellar P-ring protein precursor FlgI
	K02397	 flagellar hook-associated protein 3 FlgL
	K02396	 flagellar hook-associated protein 1 FlgK
	K02391	 flagellar basal-body rod protein FlgF
	K02390	 flagellar hook protein FlgE
	K02393	 flagellar L-ring protein precursor FlgH
	K02392	 flagellar basal-body rod protein FlgG
	K02386	 flagella basal body P-ring formation protein FlgA
	K02557	 chemotaxis protein MotB
	K02556	 chemotaxis protein MotA
	K02400	 flagellar biosynthesis protein FlhA
	K02418	 flagellar protein FliO/FliZ
	K02389	 flagellar basal-body rod modification protein FlgD
	K02412	 flagellum-specific ATP synthase [EC:3.6.3.14]
	K02387	 flagellar basal-body rod protein FlgB
	K02410	 flagellar motor switch protein FliG
	K02411	 flagellar assembly protein FliH
	K02416	 flagellar motor switch protein FliM
	K02417	 flagellar motor switch protein FliN/FliY
	K02407	 flagellar hook-associated protein 2
	K02406	 flagellin

Sulfur metabolism
	Assimilation
		K00392	 sir; sulfite reductase (ferredoxin) [EC:1.8.7.1]
		K00380 + K00381 cysJ; sulfite reductase (NADPH) flavoprotein alpha-component [EC:1.8.1.2] + cysI; sulfite reductase (NADPH) hemoprotein beta-component [EC:1.8.1.2]
	Reversible Dissimilatory
		K00958	sat; sulfate adenylyltransferase
		K00395 + K00394	aprB; adenylylsulfate reductase, subunit B [EC:1.8.99.2] + aprA; adenylylsulfate reductase, subunit A [EC:1.8.99.2]
		K11180 + K11181	dsrA; sulfite reductase, dissimilatory-type alpha subunit [EC:1.8.99.3] + dsrB; sulfite reductase, dissimilatory-type beta subunit [EC:1.8.99.3]
	Thiosulfate oxidation measured as a fraction of KOs:
		soxA K17222
		soxB K17224
		soxC K17225
		soxX K17223
		soxY K17226
		soxZ K17227
	Alternative thiosulfate oxidation
		K16936 doxA; thiosulfate dehydrogenase [quinone] small subunit [EC:1.8.5.2]
		K16937 doxD; thiosulfate dehydrogenase [quinone] large subunit [EC:1.8.5.2]
		K19713 tsdA; thiosulfate dehydrogenase [EC:1.8.2.2]
	Sulfur reduction (reversible reaction)
		K17219 sreA; sulfur reductase molybdopterin subunit
		K17220 sreB; sulfur reductase FeS subunit
		K17221 sreC; sulfur reductase membrane anchor
		K08352 psrA; thiosulfate reductase / polysulfide reductase chain A
		K08353 psrB; thiosulfate reductase electron transport protein
		K08354 psrC; thiosulfate reductase cytochrome b subunit
		K17993 hydA; sulfhydrogenase subunit alpha
		K17996 hydB; sulfhydrogenase subunit beta (sulfur reductase)
		K17995 hydG; sulfhydrogenase subunit gamma (sulfur reductase)
		K17994 hydD; sulfhydrogenase subunit delta
	Aerobic sulfur disproportionation
		K16952 sor; sulfur oxygenase/reductase [EC:1.13.11.55]
	K17725 sdo; sulfur dioxygenase
	K05301 sorB; sulfite dehydrogenase
	Sulfide oxidation
		K17218 sqr; sulfide:quinone oxidoreductase [EC:1.8.5.4]
		K17229 fccB; sulfide dehydrogenase [flavocytochrome c] flavoprotein chain
	Sulfite dehydrogenase (quinone)
		K21307 + K21308 + K21309 soeABC
	DMSP demethylation
		K17486 dmdA; dimethylsulfoniopropionate demethylase
	DMS dehydrogenase
		K16964 ddhA; dimethylsulfide dehydrogenase subunit alpha 
		K16965 ddhB; dimethylsulfide dehydrogenase subunit beta
		K16966 ddhC; dimethylsulfide dehydrogenase subunit gamma
	DMSO reductase
		K07306 dmsA; anaerobic dimethyl sulfoxide reductase subunit A
		K07307 dmsB; anaerobic dimethyl sulfoxide reductase subunit B (DMSO reductase iron- sulfur subunit)
		K07308 dmsC; anaerobic dimethyl sulfoxide reductase subunit C (DMSO reductase anchor subunit)

Methanogenesis
	Methanogenesis via methanol
		K14080 mtaA; [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase
		K04480 mtaB; methanol---5-hydroxybenzumidazolylcobamide Co-methyltransferase
		K14081 mtaC; methanol corrinoid protein
	Methanogenesis via dimethylamine
		K14082 mtbA; [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase
		K16178 mtbB; dimethylamine---corrinoid protein Co-methyltransferase 
	Methanogenesis via dimethylsulfide, methanethiol, methylpropanoate
		K16954 mtsA; methylthiol:coenzyme M methyltransferase
		K16955 mtsB; methylated-thiol--corrinoid protein
	Methanogenesis via methylamine
		K16176 mtmB; monomethylamine methyltransferase
	Methanogenesis via trimethylamine
		K14083 mttB; trimethylamine methyltransferase
	Methanogenesis via acetate
		K00193 cdhC; acetyl-CoA decarbonylase/synthase complex subunit beta 
		K00194 cdhD; acetyl-CoA decarbonylase/synthase complex subunit delta 
		K00197 cdhE; acetyl-CoA decarbonylase/synthase complex subunit gamma
	Methanogenesis via CO2
		K00200 + K00201 + K00202 + K00203 + K11261 + K00205 fmdABCDEF; formylmethanofuran dehydrogenase
		K00200 + K00201 + K00202 + K00203 fwdABCD; tungsten-containing formylmethanofuran dehydrogenase
		K00672 ftr; formylmethanofuran--tetrahydromethanopterin N-formyltransferase 
		K01499 mch; methenyltetrahydromethanopterin cyclohydrolase
		K13942 hmd; 5,10-methenyltetrahydromethanopterin hydrogenase
		K00320 mer; 5,10-methylenetetrahydromethanopterin reductase
		K00577 + K00578 + K00579 + K00580 + K00581 + K00582 + K00583 + K00584 mtrABCDEFGH; tetrahydromethanopterin S-methyltransferase
	Coenzyme M reduction to methane
		K00399 + K00401 + K00402 mcrABCD; methyl-coenzyme M reductase
	Coenzyme B/Coenzyme M regeneration
		K03388 + K03389 + K03390 + K08264 + K08265 hdrABCDE; CoB-CoM heterodisulfide reductase
	Dimethylamine/trimethylamine dehydrogenase
		K00317 dmd-tmd; dimethylamine/trimethylamine dehydrogenase

Methane oxidation
	K16157 + K16158 + K16159 + K16161 mmoXYZC; soluble methane monooxygenase
	K14028 + K14029 mxaFI methanol dehydrogenase
	K17066 MOX alcohol oxidase

Transporters
	K02040 + K02037 + K02038 + K02036 pstABCS; phosphate
	K02044 + K02042 + K02041 phnDEC; phosphonate
	K02064 + K02063 + K02062 tbpA,thiPQ; thiamin
	K06858 + K06073 + K06074 btuFCD; vitamin B12
	K11959 + K11960 + K11961 + K11962 + K11963 urtABCED; urea


Thiamin biosynthesis
	Generation of 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
		K03148 thiF; sulfur carrier protein ThiS adenylyltransferase
		K04487 iscS; cysteine desulfurase
		K03150 thiH; 2-iminoacetate synthase OR K03153 thiO; glycine oxidase
		K03151 thiI; thiamine biosynthesis protein ThiI
		K01662 dxs; 1-deoxy-D-xylulose-5-phosphate synthase
		K03149 thiG; thiazole synthase
		K10810 tenI; thiazole tautomerase OR THI4 K03146; thiamine thiazole synthase
	Generation of 4-amino-2-methyl-5-(diphosphomethyl)pyrimidine
		K18278 THI5; pyrimidine precursor biosynthesis enzyme OR K03147 thiC; phosphomethylpyrimidine synthase OR K00877 THI20; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase / thiaminase OR K00941 thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase OR K14153 thiDE; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase
		K00877 THI20; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase / thiaminase OR K00941 thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 
	Terminal biosynthesis
		K00788 thiE; thiamine-phosphate pyrophosphorylase OR K14153 thiDE; hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase OR K14154 THI6;thiamine-phosphate diphosphorylase / hydroxyethylthiazole kinase 
		K00946 thiL; thiamine-monophosphate kinase 

Riboflavin biosynthesis
	K02858 ribB; 3,4-dihydroxy 2-butanone 4-phosphate synthase OR K14652 ribAB; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
	K00082 ribD2; 5-amino-6-(5-phosphoribosylamino)uracil reductase OR K11752 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase 
	K00794 ribH; 6,7-dimethyl-8-ribityllumazine synthase
	K00793 ribE; riboflavin synthase
	Conversion to FMN and FAD (not included in script)
		K00861 RFK; riboflavin kinase OR K20884 FHY; riboflavin kinase / FMN hydrolase OR K11753 ribF; riboflavin kinase / FMN adenylyltransferase
		K14656 ribL; FAD synthetase OR K00953 FLAD1; FAD synthetase

Cobalamin biosynthesis
	K00798 pduO; cob(I)alamin adenosyltransferase OR K19221 cobA; cob(I)alamin adenosyltransferase
	K02232 cobQ; adenosylcobyric acid synthase
	K02225 cobC; cobalamin biosynthetic protein CobC
	K02227 cobD; adenosylcobinamide-phosphate synthase
	K02231 cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase
	If cobU is present, this function in the biosynthesis process has already been counted:
		K19712 cobY; adenosylcobinamide-phosphate guanylyltransferase
	K02233 cobV; adenosylcobinamide-GDP ribazoletransferase
	K02226 cobC; alpha-ribazole phosphatase
	K00768 cobT; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Oxidative phosphorylation (Nuo, ATPases)
	F-type ATPase
		K02111 + K02112 + K02115 + K02113 + K02114 + K02108 + K02109 + K02110 atpFBCHGDAE
	V-type ATPase
		K02117 + K02118 + K02119 + K02120 + K02121 + K02122 + K02107 + K02123 + K02124 ntpABCDEFIK,ahaH
	NADH-quinone oxidoreductase
		K00330 + K00331 + K00332 + K00333 + K00334 + K00335 + K00336 + K00337 + K00338 + K00339 + K00340 + K00341 + K00342 + K00343 nuoABCDEFGHIJKLMN
	NAD(P)H-quinone oxidoreductase
		K05574 + K05582 + K05581 + K05579 + K05572 + K05580 + K05578 + K05576 + K05577 + K05575 + K05573 + K05583 + K05584 + K05585 ndcABCDEFGHIJKLMN
	Cytochrome c oxidase, cbb3-type
		K00404 + K00405 + K00407 + K00406 ccoPQNO
	Cytochrome bd complex
		K00425 + K00426 cydAB
	cytochrome o ubiquinol oxidase
		K02300 + K02299 + K02298 + K02297 cyoABCD
	cytochrome c oxidase
		K02277 + K02276 + K02274 + K02275 coxABCD
	cytochrome aa3-600 menaquinol oxidase
		K02829 + K02828 + K02827 + K02826 qoxABCD
	ubiquinol-cytochrome c reductase
		K00411 petA; ubiquinol-cytochrome c reductase iron-sulfur subunit
		K00410 fbcH; ubiquinol-cytochrome c reductase cytochrome b/c1 subunit
	
Hydrogen redox
	K00437 + K18008 hydB2,hydA2; NiFe hydrogenase
	K18016 + K18017 + K18023 mbhLJK; membrane-bound hydrogenase
	K00533 + K00534 hupSL; ferrodoxin hydrogenase
	K05922 + K05927 hydA3,hydB3; hydrogen:quinone oxidoreductase
	K00436 + K18005 + K18006 + K18007 hoxHFUY; NAD-reducing hydrogenase
	K17992 + K18330 + K18331 + K18332 hndABCD; NADP-reducing hydrogenase
	K06282 + K06281 + K03620 hyaABC; NiFe hydrogenase Hyd-1

Photosynthesis
	Photosystem II (major reaction center proteins - 21 additional proteins possible as part of structure)
		K02703 + K02706 + K02705 + K02704 + K02707 + K02708
	Photosystem I
		K02689 + K02690 + K026891 + K02692 + K02693 + K02694 + K02696 + K02697 + K02698 + K02699 + K02700 + K08905 + K02695 + K02701 + K14332 + K02702
	Cytochrome b6/f complex
		K02635 + K02637 + K02634 + K02636 + K02642 + K02643 + K03689 + K02640
	Anoxygenic photosynthesis
		Anoxygenic reaction center II (pufML)
		K08929 + K08928
		Anoxygenic reaction center I (pscABCD)
		K08940 + K08941 + K08942 + K08943
	Retinal biosynthesis (necessary for proteorhodopsin)
		K06443 crtY; lycopene beta-cyclase
		K02291 crtB; 15-cis-phytoene/all-trans-phytoene synthase 
		K10027 crtI; phytoene desaturase 
		K13789 crtE; geranylgeranyl diphosphate synthase, type II
	Retinal produced via cleavage from apo-carotenols
		K00464 diox1; all-trans-8'-apo-beta-carotenal 15,15'-oxygenase 

Entner-Doudoroff Pathway (to generate pyruvate, alt to glycolysis)
	K00036 G6PD; glucose-6-phosphate 1-dehydrogenase
	K01057 PGLS; 6-phosphogluconolactonase OR K07404 pgl; 6-phosphogluconolactonase
	Alternative to previous steps: K13937 H6PD; hexose-6-phosphate dehydrogenase
	K01690 edd; phosphogluconate dehydratase
	K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase OR K17463 dgaF; 2-dehydro-3-deoxy-phosphogluconate aldolase OR K11395 kdpgA; 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase

Mixed Acid Fermentation (conversion of pyruvate to fermentation products)
	Pyruvate to Lactate
		K00016 LDH; L-lactate dehydrogenase
	Pyruvate to Formate + Acetyl-CoA
		K00656 pf1D; formate C-acetyltransferase
	Formate to CO2 & H2
		(K00122 + K00125 + K00126 + K00123 + K00124 + K00127 formate dehydrogenase)
	To Acetate
		Direct from pyruvate
			K00156 poxB; pyruvate dehydrogenase (quinone)
		Direct from pyruvate via Acetyl-P
			K00158 poxL; pyruvate oxidase + K01512 acyP; acylphosphatase
		Direct from acetyl-CoA
			K01067 ACH1; acetyl-CoA hydrolase
		From acetyl-CoA via Acetyl-P
			(K13788 pta; phosphate acetyltransferase OR K04020 eutD; phosphotransacetylase) + K01512 acyP; acylphosphatase
		From lactate
			K00467 lactate 2-monooxygenase
	To Ethanol
		Step 1 to Acetaldehyde from Acetate
			(K00128 + K14085 + K00149 aldehyde dehydrogenase (NAD+)) OR K00129 aldehyde dehydrogenase (NAD(P)+) OR K00138 aldB; aldehyde dehydrogenase
		Step 1 to Acetaldehyde from Acetyl-CoA (reversible)
			K00132 + K04072 + K04073 + K18366 + K04021 acetaldehyde dehydrogenase (acetylating)
		Step 2 to Ethanol from Acetaldehyde
			(K13951 OR K13980 OR K13952 OR K13953 OR K13954 OR K00001 OR K00121 OR K04072 OR K18857 alcohol dehydrogenase) OR (K14028 + K14029 methanol dehydrogenase (cytochrome c)) OR K00114 exaA; alcohol dehydrogenase (cytochrome c) OR K00002 adh; alcohol dehydrogenase (NADP+) OR K04022 eutG; alcohol dehydrogenase 	
	PEP to Succinate via OAA, malate & fumarate
		Step 1
			K01596 pckA; phosphoenolpyruvate carboxykinase (GTP) OR K20370 PEPCK; phosphoenolpyruvate carboxykinase (diphosphate) OR K01610 pckA; phosphoenolpyruvate carboxykinase (ATP)
		Step 2
			(K00025 + K00026 + K00024 malate dehydrogenase) OR K00051 malate dehydrogenase (NADP+) OR K00116 mqo; malate dehydrogenase (quinone)
		Step 3
			(K01676 + K01677 + K01678 + K01679 fumarate hydratase, class I)
		Step 4
			(K00244 + K00245 + K00246 + K00247 fumarate reductase flavoprotein)
Naphthalene degradation to salicylate
	K14579 + K14580 + K14578 + K14581 nahAabcd; naphthalene 1,2-dioxygenase (4 subunits)
	K14582 nahB; cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase
	K14583 nahC; 1,2-dihydroxynaphthalene dioxygenase
	K14584 nahD; 2-hydroxychromene-2-carboxylate isomerase
	K14585 nahE; trans-o-hydroxybenzylidenepyruvate hydratase-aldolase 
	K00152 nahF; salicylaldehyde dehydrogenase

Biofilm formation
	K11935 + K11931 + K11936 + K11937 pgaABCD; biofilm PGA synthesis protein
	K13654 mcbR; GntR family transcriptional regulator, colanic acid and biofilm gene transcriptional regulator
	K12148 bssS; biofilm regulator BssS
	K13650 mcbA; MqsR-controlled colanic acid and biofilm protein A
	K04335 + K04334 + K04336 csgABC; curli fimbriae biosynthesis
	K12687 flu; antigen 43

Competence-related DNA transporter 
	Core components
	K02237  comEA; competence protein ComEA
	K01493  comEB; dCMP deaminase [EC:3.5.4.12]
	K02238  comEC; competence protein ComEC
	K02239  comER; competence protein ComER
	K02240  comFA; competence protein ComFA
	K02241  comFB; competence protein ComFB
	K02242  comFC; competence protein ComFC
	K02243  comGA; competence protein ComGA
	K02244  comGB; competence protein ComGB
	K02245  comGC; competence protein ComGC
	K02246  comGD; competence protein ComGD
	K02247  comGE; competence protein ComGE
	K02248  comGF; competence protein ComGF
	K02249  comGG; competence protein ComGG
	Related components
	K02250  comK; competence protein ComK
	K02251  comQ; competence protein ComQ
	K02252  comS; competence protein ComS
	K02253  comX; competence protein ComX
	K02254  comZ; competence protein ComZ
	Additional competence factors
	K12292	comA; ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-]
	K07680	comP; two-component system, NarL family, sensor histidine kinase ComP [EC:2.7.13.3]
	K12293	comB; competence factor transport accessory protein ComB
	K12415	comC; competence-stimulating peptide
	K12294	comD; two-component system, AgrA family, sensor histidine kinase ComD [EC:2.7.13.3]
	K12295	comE; two-component system, AgrA family, response regulator ComE
	K12296	comX1_2; competence protein ComX

Anaplerotic Reactions
	Glyoxylate shunt
	Requires the presence of both isocitrate lyase and malate synthase
	K01637	aceA; isocitrate lyase
	K01638	aceB; malate synthase
	Anaplerotic enzymes
	All reactions are reversible. Organisms can have 0-4 of the pathways
	K00029	maeB; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) or 'malic' enzyme
	K01958	pyruvate carboxylase OR K01959 pycA + K01960 pycB; pyruvate carboxylase subunits A + B
	K01595	ppc; phosphoenolpyruvate carboxylase
	K01610	pckA; phosphoenolpyruvate carboxykinase (ATP) OR K01596 pckA; phosphoenolpyruvate carboxykinase (GTP) OR K20370 PEPCK; phosphoenolpyruvate carboxykinase (diphosphate)

Sulfolipid biosynthesis
	Two components SQD1/sqdB and SQD2 (SQD2 may not be present in bacteria/archaea but belongs to the CAZy GT4 family)
	K06118	sqdB; UDP-sulfoquinovose synthase 
	K06119	SQD2; sulfoquinovosyltransferase

C-P lyase
	There is key enzyme that performs the cleavage of methane from the C-bond PhnJ, but the entire pathway requires an operon that leads to synthesis of a ribosyl phosphonate
	The transporter for phosphonate phnCED is represented in the transporter subcategory
	K02043	phnF; GntR family transcriptional regulator, phosphonate transport system regulatory protein
	K06166	phnG; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit 
	K06164	phnH; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit 
	K06164	phnI; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit 
	K06163	phnJ; alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase
	K05781	phnK; putative phosphonate transport system ATP-binding protein
	K05780	phnL; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit
	K06162	phnM; alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase
	k05775	phnN; ribose 1,5-bisphosphokinase
	k09994	phnO; aminoalkylphosphonate N-acetyltransferase
	K06167	phnP; phosphoribosyl 1,2-cyclic phosphate phosphodiesterase

Bacterial Secretion Systems
	Type I Secretion
		K12340	tolC
		K11003	HlyD
		K11004	HylB
	Type III Secretion
		K03221	yscF
		K04056	yscO
		K04057	yscP
		K04059	yscX
		K03219	yscC
		K04058	yscW
		K03222	yscJ
		K03226	yscR
		K03227	yscS
		K03228	yscT
		K03229	yscU
		K03230	yscV
		K03224	yscN
		K03225	yscQ
		K03223	yscL
	Type II Secretion
		K02453	gspD
		K02465	gspS
		K02452	gspC
		K02455	gspF
		K02456	gspG
		K02457	gspH
		K02458	gspI
		K02459	gspJ
		K02460	gspK
		K02461	gspL
		K02462	gspM
		K02454	gspE
		K02464	gspO
	Type IV Secretion
		K03149	virB1
		K03197	virB2
		K03198	virB3
		K03200	virB5
		K03202	virB7
		K03204	virB9
		K03201	virB6
		K03203	virB8
		K03195	virB10
		K03199	virB4
		K03196	virB11
		K03205	virD4
	Type VI Secretion
		K11904	vgrG
		K11903	hcp
		K11960	lip
		K11891	icmF
		K11892	dotU
		K11907	clpV
		K11912	ppkA
		K11913	fha1
		K11915	ppA
	Sec-SRP
		K03072	secD
		K03074	secF
		K03073	secE
		K03075	secG
		K03076	secY
		K03210	yajC
		K03217	yidC
		K03070	secA
		K13301	secM
		K03110	ftsY
		K03071	secB
		K03106	ffh
		K12257	secDF
	Twin Arginine Targeting
		K03116	tatA
		K03117	tatB
		K03118	tatC
		K03425	tatE
	Type Vabc Secretion
		K11028	vacA; Type Va
		K11017	shlB; Type Vb
		K11016	shlA; Type Vb
		K12341	yadA; Type Vc
		K12342	yadBC; Type Vc

Serine pathway
	Serine glyoxylate transaminase if an essential enzyme this pathway
	K00600	glyA; glycine hydroxymethyltransferase
	K00830	AGXT; alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase
	K00018	hprA; glycerate dehydrogenase
	K11529	gckA; glycerate 2-kinase	
	K01689	eno; enolase
	K01595	ppc; phosphoenolpyruvate carboxylase
	K00024	mdh; malate dehydrogenase
	K08692	mtkB; malate-CoA ligase subunit alpha
	K14067	mtkA; malate-CoA ligase subunit beta
	K08692	mtkB; malate-CoA ligase subunit alpha

Dissimilatory arsenic reduction
	Assess the completion of the ars operon, consists of either arsRBC or arsRDABC
	arsD does not have a KO value
	K00537	arsC; arsenate reductase OR K03741 arsC; arsenate reductase OR K18701 arsC; arsenate-mycothiol transferase
	K03325	arsB; arsenite transporter OR K03893 arsB; arsenical pump membrane protein
	K03892	arsR; ArsR family transcriptional regulator
	K01551	arsA; arsenite/tail-anchored protein-transporting ATPase

Na+-transporting NADH:ubiquinone oxidoreductase
	K00346	Na+-transporting NADH:ubiquinone oxidoreductase subunit A
	K00347	Na+-transporting NADH:ubiquinone oxidoreductase subunit B
	K00348	Na+-transporting NADH:ubiquinone oxidoreductase subunit C
	K00349	Na+-transporting NADH:ubiquinone oxidoreductase subunit D
	K00350	Na+-transporting NADH:ubiquinone oxidoreductase subunit E
	K00351	Na+-transporting NADH:ubiquinone oxidoreductase subunit F

Metal Transporters
	K02007 + K02008	cobalt transport protein CbiMQ
	K18837	cobalt transport protein CbtA
	K03284	cobalt transport protein CorA
	K15584	nickel ABC transporter, substrate-binding NikA
	K17686	copper P-type transporter CopA
	K04759	ferrous iron transporter FeoB
	K02012	ferric iron ABC transporter, substrate-binding AfuA
	K03322	Fe-Mn transporter protein MntH

Amino acid biosynthesis
	Version.1.0.6. Emphasize only the final processing step - essentially ask the question "Is the final step to convert the
	last precusor to the final amino acid present?" For multiple subunit proteins, all subunits must be present.
	K00013	hisD; histidinol dehydrogenase 	histidine - positive charge
	K01755	argH; argininosuccinate lyase OR K14681 argHA argininosuccinate lyase / amino-acid N-acetyltransferase	arginine - positive charge
	K01586  lysA; diaminopimelate decarboxylaselysine OR K12526 lysAC; bifunctional diaminopimelate decarboxylase / aspartate kinase OR K05831 lysK [amino group carrier protein]-lysine/ornithine hydrolase OR K00290 LYS1; saccharopine dehydrogenase 	lysine - positive charge
	K01079	serB; phosphoserine phosphatase OR K02203 thrH; phosphoserine / homoserine phosphotransferase OR psp; K22305 phosphoserine phosphatase OR K00600 glyA; glycine hydroxymethyltransferase	serine - polar uncharged side chain
	K01733	thrC; threonine synthase OR K01620 ltaE; threonine aldolase	threonine - polar uncharged side chain
	K01914	asnA; aspartate--ammonia ligase OR K01953 asnB; 	
asparagine synthase (glutamine-hydrolysing)	asparagine - polar uncharged side chain
	K01915	glnA; glutamine synthetase	glutamine - polar uncharged side chain
	K12339	cysM; S-sulfo-L-cysteine synthase OR CTH; K01758 cystathionine gamma-lyase OR CTH; K17217 cystathionine gamma-lyase / homocysteine desulfhydrase OR cysO; K01738 cysteine synthase OR cysO; K10150 cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase	cysteine - special cases
	K00600	glyA; glycine hydroxymethyltransferase OR K01620 ltaE; threonine aldolase	glycine - special cases
	K00286	proC; OR K01750 ocd; ornithine cyclodeaminasepyrroline-5-carboxylate reductase	proline - special cases
	K14260	ala; alanine-synthesizing transaminase OR asdA; K09758 aspartate 4-decarboxylase OR K19244 ala; alanine dehydrogenase OR K00259 ald; alanine dehyrogenase	alanine - hydrophobic side chain
	K00826	ilvE; branched-chain amino acid aminotransferase AND K01687 ilvD; dihydroxy-acid dehydratase isoleucine AND K00053; ilvC ketol-acid reductoisomerase AND K01652 ilvB; acetolactate synthase I/II/III large subunit AND K01653 ilvH; acetolactate synthase I/III small subunit AND K11258; ilvM acetolactate synthase II small subunit 	valine - hydrophobic side chain
	K00549	metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OR K00548 metH; 5-methyltetrahydrofolate--homocysteine methyltransferase	methionine - hydrophobic side chain
	K00832	tyrB; aromatic-amino-acid transaminase OR K00838 ARO8; aromatic amino acid aminotransferase I / 2-aminoadipate transaminase OR K01713 pheC; cyclohexadienyl dehydratase OR K05359 ADT; arogenate/prephenate dehydratase OR K04518 pheA2; prephenate dehydratase	phenylalanine - hydrophobic side chain
	K00826	ilvE; branched-chain amino acid aminotransferase AND K01687 ilvD; dihydroxy-acid dehydratase isoleucine AND K00053; ilvC ketol-acid reductoisomerase AND K01652 ilvB; acetolactate synthase I/II/III large subunit AND K01653 ilvH; acetolactate synthase I/III small subunit AND K11258; ilvM acetolactate synthase II small subunit 	isoleucine - hydrophobic side chain
	K00826	ilvE; branched-chain amino acid aminotransferase AND K00052 leuB; 3-isopropylmalate dehydrogenase AND K01703 leuC; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit AND K01649 leuA; 2-isopropylmalate synthase	leucine - hydrophobic side chain
	K01695	trpA; tryptophan synthase alpha chain AND K01696 trpB; tryptophan synthase beta chain OR K06001 trpB; tryptophan synthase beta chain	tryptophan - hydrophobic side chain
	K00832	tyrB; aromatic-amino-acid transaminase OR K00838 ARO8; aromatic amino acid aminotransferase I / 2-aminoadipate transaminase OR K00220 tyrC; cyclohexadieny/prephenate dehydrogenase OR K24018; cyclohexadieny/prephenate dehydrogenase OR K15226 tyrAa; arogenate dehydrogenase	tyrosine - hydrophobic side chain
	K00811	ASP5; OR K00812 aspB; K00813 aspC; K11358 yhdR; K14454 GOT1; K14455 GOT2 aspartate aminotransferase	aspartate - negative charge
	K00811	ASP5; OR K00812 aspB; K00813 aspC; K11358 yhdR; K14454 GOT1; K14455 GOT2 aspartate aminotransferase	glutamate - negative charge
	
	
Polyethylene terephthalate degradation
	K21104	poly(ethylene terephthalate) hydrolase
	K21105	mono(ethylene terephthalate) hydrolase
	K18074	tphA2; terephthalate 1,2-dioxygenase oxygenase component alpha subunit AND K18075 tphA3; terephthalate 1,2-dioxygenase oxygenase component beta subunit OR K18077	tphA1; terephthalate 1,2-dioxygenase reductase component
	K18076	tphB; 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase

Storage carbon (starch/glycogen) and phosphorous (polyphosphate)
	STARCH Synthesis
	K00703	glgA; starch synthase
	K00975	glgC; glucose-1-phosphate adenylyltransferase
	K00700	glgB; 1,4-alpha-glucan branching enzyme OR K16149 1,4-alpha-glucan branching enzyme
	STARCH Degradation -- any pathway that converts glycogen will be included. Only recording 1 instance of transformation.
	starch > glucose-6P
		K00688	glgP; glycogen phosphorylase OR K16153 glycogen phosphorylase/synthase OR K00705 malQ; 4-alpha-glucanotransferase OR K22451 jgt; 4-alpha-glucanotransferase OR K02438 glgX; glycogen debranching enzyme OR K01200 pulA; pullulanase
	starch > D-glucose
		K21574	susB; glucan 1,4-alpha-glucosidase
	starch > cyclodextrin
		K00701	cgt; cyclomaltodextrin glucanotransferase
	starch > maltodextrin
		K01214	treX; isoamylase
	starch > dextrin
		K01176	amyA; alpha-amylase OR K07405 alpha-amylase OR K05343 treS; maltose alpha-D-glucosyltransferase / alpha-amylase
		K01177	beta-amylase
		K05992	amyM; maltogenic alpha-amylase OR K01208 nplT; cyclomaltodextrinase / maltogenic alpha-amylase / neopullulanase
	POLYPHOSPHATE bidirectional
	K00937	ppk; polyphosphate kinase OR K22468 ppk2; polyphosphate kinase
	K01507	ppa; inorganic pyrophosphatase OR K15986 ppaC; manganese-dependent inorganic pyrophosphatase OR K06019 ppaX; pyrophosphatase PpaX
	PHA/PHB synthesis/degradation
	K00023	phbB; acetoacetyl-CoA reductase
	K00626	phaA; acetyl-CoA C-acetyltransferase AND K03821 phaC; polyhydroxyalkanoate synthase subunit PhaC AND K22881 phaE; polyhydroxyalkanoate synthase subunit PhaE

Carotenoids
	Terpenoid backbone biosynthesis has two biosynthetic pathways:
	Mevalonate pathway 
		K01641	hmgs; HMG-CoA synthase
		K00054	mvaA; hydroxymethylglutaryl-CoA reductase
		K00869	mvaK1; mevalonate kinase
		K00938	mvaK2; phosphomevalonate kinase
		K01597	mvaD; mevalonate-PP decarboxylase
	MEP/DOXP pathway
		K01662	dxs; DOXP synthase
		K00099	ispC; DOXP reductoisomerase
		K00991	ispD; CDP-ME synthase
		K00919	ispE; CDP-ME kinase
		K01770	ispF; MEcPP synthase
		K03526	ispG; HMB-PP synthase
		K03527	ispH; HMB-PP reductase
	Biosynthesis of staphyloaxanthin (some overlap with the carotenoids below, but with a different backbone)
		K10208	crtM; 4,4'-diapophytoene synthase
		K10209	crtN; 4,4'-diapophytoene desaturase 
		K10210	crtP; diapolycopene oxygenase
		K00128	AldH; aldehyde dehydrogenase
		K10211	crtQ; 4,4'-diaponeurosporenoate glycosyltransferase
		K10212	crtO; glycosyl-4,4'-diaponeurosporenoate acyltransferase
	Carotenoid biosynthesis = for full functionality requires a complete "Backbone biosynthesis" + at least one of the end-product results
	Backbone biosynthesis
		K23155	crtE; GGPP synthase
		K02291	crtB; phytoene synthase
		K02291	crtI; phytoene desaturase
		K00514	crtQ; phytoene desaturase
		K06443	crtL; lycopene cyclase OR K14606 cruP; lycopene cyclase
	End-product astaxanthin
		K09836	crtW; beta-carotense ketolase OR K02292 crtO; beta-carotense ketolase
	End-product nostoxanthin
		K02294	crtR; beta-carotene hydroxylase
	End-product zeaxanthin diglucoside
		K02294	crtR; beta-carotene hydroxylase
		K14596	crtX; zeaxanthin glucotransferase
	End-product myxoxanthophylls (2-hydroxymyxol 2'-methylpentoside)
		K08977	cruF; carotenoid 1,2-hydratase
		K02294	crtR; beta-carotene hydroxylase
		K00721	cruG; dolichol-phosphate mannosyltransferase
	